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PMC:1448208 / 34525-35509 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T20423 983-984 . denotes .
T20422 979-983 NN denotes MSUD
T20421 976-978 IN denotes of
T20420 958-970 JJ denotes intermediate
T20419 971-975 NN denotes form
T20418 954-957 DT denotes the
T20417 951-953 IN denotes of
T20416 938-944 NN denotes animal
T20415 932-937 JJ denotes small
T20414 925-931 JJ denotes useful
T20413 945-950 NN denotes model
T20412 923-924 DT denotes a
T20411 897-907 VBN denotes engineered
T20410 885-896 RB denotes genetically
T20409 908-912 NNS denotes mice
T20408 879-884 DT denotes these
T20407 877-879 , denotes ,
T20406 863-868 JJ denotes human
T20405 869-877 NNS denotes patients
T20404 859-862 DT denotes the
T20403 856-858 IN denotes to
T20402 844-850 NN denotes rescue
T20401 851-855 NNS denotes mice
T20400 840-843 DT denotes the
T20399 837-839 IN denotes of
T20398 813-823 JJ denotes phenotypic
T20397 824-836 NNS denotes similarities
T20396 809-812 DT denotes the
T20395 806-808 IN denotes of
T20394 913-922 VBP denotes represent
T20393 798-805 IN denotes Because
T20392 797-984 sentence denotes Because of the phenotypic similarities of the rescue mice to the human patients, these genetically engineered mice represent a useful small animal model of the intermediate form of MSUD.
T20391 796-797 . denotes .
T20390 795-796 -RRB- denotes ]
T20389 794-795 CD denotes 1
T20388 793-794 -LRB- denotes [
T20387 786-792 JJ denotes normal
T20386 783-785 IN denotes of
T20385 781-782 NN denotes %
T20384 778-779 SYM denotes –
T20383 779-781 CD denotes 30
T20382 777-778 CD denotes 3
T20381 774-776 IN denotes of
T20380 768-773 NN denotes range
T20379 764-767 DT denotes the
T20378 761-763 IN denotes in
T20377 746-751 NN denotes BCKDH
T20376 742-745 CC denotes and
T20375 752-760 NN denotes activity
T20374 737-741 NN denotes BCAA
T20373 734-736 IN denotes of
T20372 727-733 NNS denotes levels
T20371 717-726 VBN denotes increased
T20370 704-716 RB denotes persistently
T20369 685-690 JJ denotes human
T20368 680-684 NN denotes MSUD
T20367 691-699 NNS denotes patients
T20366 667-679 JJ denotes intermediate
T20365 664-666 IN denotes of
T20364 700-703 VBP denotes are
T20363 654-663 NNS denotes hallmarks
T20362 650-653 DT denotes The
T20361 649-797 sentence denotes The hallmarks of intermediate MSUD human patients are persistently increased levels of BCAA and BCKDH activity in the range of 3–30% of normal [1].
T20360 648-649 . denotes .
T20359 639-648 NNS denotes knockouts
T20358 635-638 CC denotes and
T20357 626-634 NNS denotes controls
T20356 618-625 IN denotes between
T20355 605-617 JJ denotes intermediate
T20354 588-594 NN denotes rescue
T20353 595-599 NNS denotes mice
T20352 582-587 DT denotes these
T20351 579-581 IN denotes of
T20350 573-578 NN denotes blood
T20349 570-572 IN denotes in
T20348 563-569 NNS denotes levels
T20347 558-562 NN denotes BCAA
T20346 600-604 VBD denotes were
T20345 553-557 IN denotes that
T20344 535-539 RB denotes also
T20343 540-552 VBD denotes demonstrated
T20342 532-534 PRP denotes We
T20341 531-649 sentence denotes We also demonstrated that BCAA levels in blood of these rescue mice were intermediate between controls and knockouts.
T20340 530-531 . denotes .
T20339 522-530 NN denotes survival
T20338 516-521 VB denotes allow
T20337 513-515 TO denotes to
T20336 502-512 JJ denotes sufficient
T20335 492-497 NN denotes liver
T20334 488-491 DT denotes the
T20333 485-487 IN denotes in
T20332 470-475 NN denotes BCKDH
T20331 476-484 NN denotes activity
T20330 463-469 JJ denotes normal
T20329 460-462 IN denotes of
T20328 458-459 NN denotes %
T20327 456-457 SYM denotes –
T20326 455-456 CD denotes 5
T20325 454-455 SYM denotes ~
T20324 457-458 CD denotes 6
T20323 449-453 RB denotes only
T20322 437-442 NN denotes mouse
T20321 443-448 NNS denotes lines
T20320 431-436 DT denotes these
T20319 428-430 IN denotes in
T20318 498-501 VBD denotes was
T20317 423-427 IN denotes that
T20316 418-422 VB denotes note
T20315 415-417 TO denotes to
T20314 403-414 JJ denotes interesting
T20313 400-402 VBZ denotes is
T20312 397-399 PRP denotes It
T20311 396-531 sentence denotes It is interesting to note that in these mouse lines only ~5–6% of normal BCKDH activity in the liver was sufficient to allow survival.
T20310 395-396 . denotes .
T20309 386-395 NN denotes adulthood
T20308 383-385 IN denotes to
T20307 362-368 NN denotes rescue
T20306 369-373 NNS denotes mice
T20305 358-361 DT denotes the
T20304 355-357 IN denotes of
T20303 374-382 VBD denotes survived
T20302 350-354 JJ denotes Many
T20301 349-396 sentence denotes Many of the rescue mice survived to adulthood.
T20300 348-349 . denotes .
T20299 330-338 JJ denotes neonatal
T20298 339-348 NN denotes lethality
T20297 326-329 DT denotes the
T20296 319-325 VB denotes rescue
T20295 316-318 TO denotes to
T20294 311-315 JJ denotes able
T20293 294-302 NN denotes knockout
T20292 303-307 NNS denotes mice
T20291 288-293 DT denotes these
T20290 285-287 IN denotes of
T20289 279-284 NN denotes liver
T20288 275-278 DT denotes the
T20287 272-274 IN denotes in
T20286 259-261 NN denotes E2
T20285 253-258 JJ denotes human
T20284 262-271 NN denotes transgene
T20283 251-252 DT denotes a
T20282 248-250 IN denotes of
T20281 237-247 NN denotes expression
T20280 308-310 VBZ denotes is
T20279 232-236 IN denotes that
T20278 227-231 VBP denotes show
T20277 224-226 PRP denotes We
T20276 223-349 sentence denotes We show that expression of a human E2 transgene in the liver of these knockout mice is able to rescue the neonatal lethality.
T20275 222-223 . denotes .
T20274 207-215 JJ denotes neonatal
T20273 201-206 JJ denotes early
T20272 216-222 NN denotes period
T20271 197-200 DT denotes the
T20270 190-196 IN denotes during
T20269 183-185 NN denotes E2
T20268 175-182 VBN denotes derived
T20267 165-174 NN denotes transgene
T20266 157-164 IN denotes without
T20265 147-156 NNS denotes knockouts
T20264 144-146 NN denotes E2
T20263 142-144 , denotes ,
T20262 137-142 RB denotes above
T20261 186-189 VBP denotes die
T20260 127-136 VBN denotes mentioned
T20259 124-126 IN denotes As
T20258 123-223 sentence denotes As mentioned above, E2 knockouts without transgene derived E2 die during the early neonatal period.
T20257 122-123 . denotes .
T20256 109-117 NN denotes knockout
T20255 118-122 NNS denotes mice
T20254 106-108 NN denotes E2
T20253 103-105 IN denotes of
T20252 97-102 NN denotes liver
T20251 93-96 DT denotes the
T20250 90-92 IN denotes in
T20249 87-89 NN denotes E2
T20248 81-86 JJ denotes human
T20247 73-80 VB denotes express
T20246 70-72 TO denotes to
T20245 50-60 JJ denotes transgenic
T20244 61-69 NN denotes strategy
T20243 48-49 DT denotes a
T20242 40-42 PRP denotes we
T20241 38-40 , denotes ,
T20240 34-38 NN denotes MSUD
T20239 21-33 JJ denotes intermediate
T20238 18-20 IN denotes of
T20237 12-17 NN denotes model
T20236 10-11 DT denotes a
T20235 43-47 VBD denotes used
T20234 3-9 VB denotes create
T20233 0-2 TO denotes To
R5341 T20233 T20234 aux To,create
R5342 T20234 T20235 advcl create,used
R5343 T20236 T20237 det a,model
R5344 T20237 T20234 dobj model,create
R5345 T20238 T20237 prep of,model
R5346 T20239 T20240 amod intermediate,MSUD
R5347 T20240 T20238 pobj MSUD,of
R5348 T20241 T20235 punct ", ",used
R5349 T20242 T20235 nsubj we,used
R5350 T20243 T20244 det a,strategy
R5351 T20244 T20235 dobj strategy,used
R5352 T20245 T20244 amod transgenic,strategy
R5353 T20246 T20247 aux to,express
R5354 T20247 T20235 advcl express,used
R5355 T20248 T20249 amod human,E2
R5356 T20249 T20247 dobj E2,express
R5357 T20250 T20247 prep in,express
R5358 T20251 T20252 det the,liver
R5359 T20252 T20250 pobj liver,in
R5360 T20253 T20252 prep of,liver
R5361 T20254 T20255 compound E2,mice
R5362 T20255 T20253 pobj mice,of
R5363 T20256 T20255 compound knockout,mice
R5364 T20257 T20235 punct .,used
R5365 T20259 T20260 mark As,mentioned
R5366 T20260 T20261 advcl mentioned,die
R5367 T20262 T20260 advmod above,mentioned
R5368 T20263 T20261 punct ", ",die
R5369 T20264 T20265 compound E2,knockouts
R5370 T20265 T20261 nsubj knockouts,die
R5371 T20266 T20265 prep without,knockouts
R5372 T20267 T20268 npadvmod transgene,derived
R5373 T20268 T20269 amod derived,E2
R5374 T20269 T20266 pobj E2,without
R5375 T20270 T20261 prep during,die
R5376 T20271 T20272 det the,period
R5377 T20272 T20270 pobj period,during
R5378 T20273 T20274 amod early,neonatal
R5379 T20274 T20272 amod neonatal,period
R5380 T20275 T20261 punct .,die
R5381 T20277 T20278 nsubj We,show
R5382 T20279 T20280 mark that,is
R5383 T20280 T20278 ccomp is,show
R5384 T20281 T20280 nsubj expression,is
R5385 T20282 T20281 prep of,expression
R5386 T20283 T20284 det a,transgene
R5387 T20284 T20282 pobj transgene,of
R5388 T20285 T20284 amod human,transgene
R5389 T20286 T20284 compound E2,transgene
R5390 T20287 T20281 prep in,expression
R5391 T20288 T20289 det the,liver
R5392 T20289 T20287 pobj liver,in
R5393 T20290 T20289 prep of,liver
R5394 T20291 T20292 det these,mice
R5395 T20292 T20290 pobj mice,of
R5396 T20293 T20292 compound knockout,mice
R5397 T20294 T20280 acomp able,is
R5398 T20295 T20296 aux to,rescue
R5399 T20296 T20294 xcomp rescue,able
R5400 T20297 T20298 det the,lethality
R5401 T20298 T20296 dobj lethality,rescue
R5402 T20299 T20298 amod neonatal,lethality
R5403 T20300 T20278 punct .,show
R5404 T20302 T20303 nsubj Many,survived
R5405 T20304 T20302 prep of,Many
R5406 T20305 T20306 det the,mice
R5407 T20306 T20304 pobj mice,of
R5408 T20307 T20306 compound rescue,mice
R5409 T20308 T20303 prep to,survived
R5410 T20309 T20308 pobj adulthood,to
R5411 T20310 T20303 punct .,survived
R5412 T20312 T20313 nsubj It,is
R5413 T20314 T20313 acomp interesting,is
R5414 T20315 T20316 aux to,note
R5415 T20316 T20313 xcomp note,is
R5416 T20317 T20318 mark that,was
R5417 T20318 T20316 ccomp was,note
R5418 T20319 T20318 prep in,was
R5419 T20320 T20321 det these,lines
R5420 T20321 T20319 pobj lines,in
R5421 T20322 T20321 compound mouse,lines
R5422 T20323 T20324 advmod only,6
R5423 T20324 T20328 nummod 6,%
R5424 T20325 T20324 punct ~,6
R5425 T20326 T20324 quantmod 5,6
R5426 T20327 T20324 punct –,6
R5427 T20328 T20318 nsubj %,was
R5428 T20329 T20328 prep of,%
R5429 T20330 T20331 amod normal,activity
R5430 T20331 T20329 pobj activity,of
R5431 T20332 T20331 compound BCKDH,activity
R5432 T20333 T20331 prep in,activity
R5433 T20334 T20335 det the,liver
R5434 T20335 T20333 pobj liver,in
R5435 T20336 T20318 acomp sufficient,was
R5436 T20337 T20338 aux to,allow
R5437 T20338 T20336 xcomp allow,sufficient
R5438 T20339 T20338 dobj survival,allow
R5439 T20340 T20313 punct .,is
R5440 T20342 T20343 nsubj We,demonstrated
R5441 T20344 T20343 advmod also,demonstrated
R5442 T20345 T20346 mark that,were
R5443 T20346 T20343 ccomp were,demonstrated
R5444 T20347 T20348 compound BCAA,levels
R5445 T20348 T20346 nsubj levels,were
R5446 T20349 T20348 prep in,levels
R5447 T20350 T20349 pobj blood,in
R5448 T20351 T20350 prep of,blood
R5449 T20352 T20353 det these,mice
R5450 T20353 T20351 pobj mice,of
R5451 T20354 T20353 compound rescue,mice
R5452 T20355 T20346 acomp intermediate,were
R5453 T20356 T20346 prep between,were
R5454 T20357 T20356 pobj controls,between
R5455 T20358 T20357 cc and,controls
R5456 T20359 T20357 conj knockouts,controls
R5457 T20360 T20343 punct .,demonstrated
R5458 T20362 T20363 det The,hallmarks
R5459 T20363 T20364 nsubj hallmarks,are
R5460 T20365 T20363 prep of,hallmarks
R5461 T20366 T20367 amod intermediate,patients
R5462 T20367 T20365 pobj patients,of
R5463 T20368 T20367 nmod MSUD,patients
R5464 T20369 T20367 amod human,patients
R5465 T20370 T20371 advmod persistently,increased
R5466 T20371 T20372 amod increased,levels
R5467 T20372 T20364 attr levels,are
R5468 T20373 T20372 prep of,levels
R5469 T20374 T20375 nmod BCAA,activity
R5470 T20375 T20373 pobj activity,of
R5471 T20376 T20374 cc and,BCAA
R5472 T20377 T20374 conj BCKDH,BCAA
R5473 T20378 T20372 prep in,levels
R5474 T20379 T20380 det the,range
R5475 T20380 T20378 pobj range,in
R5476 T20381 T20380 prep of,range
R5477 T20382 T20383 quantmod 3,30
R5478 T20383 T20385 nummod 30,%
R5479 T20384 T20383 punct –,30
R5480 T20385 T20381 pobj %,of
R5481 T20386 T20385 prep of,%
R5482 T20387 T20386 pobj normal,of
R5483 T20388 T20389 punct [,1
R5484 T20389 T20364 parataxis 1,are
R5485 T20390 T20389 punct ],1
R5486 T20391 T20364 punct .,are
R5487 T20393 T20394 prep Because,represent
R5488 T20395 T20393 pcomp of,Because
R5489 T20396 T20397 det the,similarities
R5490 T20397 T20393 pobj similarities,Because
R5491 T20398 T20397 amod phenotypic,similarities
R5492 T20399 T20397 prep of,similarities
R5493 T20400 T20401 det the,mice
R5494 T20401 T20399 pobj mice,of
R5495 T20402 T20401 compound rescue,mice
R5496 T20403 T20397 prep to,similarities
R5497 T20404 T20405 det the,patients
R5498 T20405 T20403 pobj patients,to
R5499 T20406 T20405 amod human,patients
R5500 T20407 T20394 punct ", ",represent
R5501 T20408 T20409 det these,mice
R5502 T20409 T20394 nsubj mice,represent
R5503 T20410 T20411 advmod genetically,engineered
R5504 T20411 T20409 amod engineered,mice
R5505 T20412 T20413 det a,model
R5506 T20413 T20394 dobj model,represent
R5507 T20414 T20413 amod useful,model
R5508 T20415 T20416 amod small,animal
R5509 T20416 T20413 compound animal,model
R5510 T20417 T20413 prep of,model
R5511 T20418 T20419 det the,form
R5512 T20419 T20417 pobj form,of
R5513 T20420 T20419 amod intermediate,form
R5514 T20421 T20419 prep of,form
R5515 T20422 T20421 pobj MSUD,of
R5516 T20423 T20394 punct .,represent

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T19745 938-944 NCBITaxon:33208 denotes animal
T19744 908-912 NCBITaxon:10088 denotes mice
T19743 885-896 SO_EXT:0000704 denotes genetically
T19742 863-868 NCBITaxon:9606 denotes human
T19741 851-855 NCBITaxon:10088 denotes mice
T19740 844-850 SO_EXT:sequence_rescue_process denotes rescue
T19739 737-741 CHEBI:22918 denotes BCAA
T19738 685-690 NCBITaxon:9606 denotes human
T19737 595-599 NCBITaxon:10088 denotes mice
T19736 588-594 SO_EXT:sequence_rescue_process denotes rescue
T19735 573-578 UBERON:0000178 denotes blood
T19734 558-562 CHEBI:22918 denotes BCAA
T19733 492-497 UBERON:0002107 denotes liver
T19732 437-442 NCBITaxon:10088 denotes mouse
T19731 386-395 UBERON:0000113 denotes adulthood
T19730 369-373 NCBITaxon:10088 denotes mice
T19729 362-368 SO_EXT:sequence_rescue_process denotes rescue
T19728 339-348 GO_EXT:fatality_or_lethality denotes lethality
T19727 330-338 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T19726 319-325 SO_EXT:sequence_rescue_process denotes rescue
T19725 303-307 NCBITaxon:10088 denotes mice
T19724 279-284 UBERON:0002107 denotes liver
T19723 262-271 SO_EXT:0000902 denotes transgene
T19722 259-261 PR_EXT:000006300 denotes E2
T19721 253-258 NCBITaxon:9606 denotes human
T19720 237-247 GO:0010467 denotes expression
T19719 207-222 UBERON:0007221 denotes neonatal period
T19718 186-189 GO:0016265 denotes die
T19717 183-185 PR_EXT:000006300 denotes E2
T19716 165-174 SO_EXT:0000902 denotes transgene
T19715 144-146 PR_EXT:000006300 denotes E2
T19714 118-122 NCBITaxon:10088 denotes mice
T19713 106-108 PR_EXT:000006300 denotes E2
T19712 97-102 UBERON:0002107 denotes liver
T19711 87-89 PR_EXT:000006300 denotes E2
T19710 81-86 NCBITaxon:9606 denotes human
T19709 73-80 GO:0010467 denotes express
T19708 50-60 SO_EXT:transgenic_entity denotes transgenic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T19587 938-944 NCBITaxon:33208 denotes animal
T19586 908-912 NCBITaxon:10088 denotes mice
T19585 885-896 SO:0000704 denotes genetically
T19584 863-868 NCBITaxon:9606 denotes human
T19583 851-855 NCBITaxon:10088 denotes mice
T19582 737-741 CHEBI:22918 denotes BCAA
T19581 685-690 NCBITaxon:9606 denotes human
T19580 595-599 NCBITaxon:10088 denotes mice
T19579 573-578 UBERON:0000178 denotes blood
T19578 558-562 CHEBI:22918 denotes BCAA
T19577 492-497 UBERON:0002107 denotes liver
T19576 437-442 NCBITaxon:10088 denotes mouse
T19575 386-395 UBERON:0000113 denotes adulthood
T19574 369-373 NCBITaxon:10088 denotes mice
T19573 303-307 NCBITaxon:10088 denotes mice
T19572 279-284 UBERON:0002107 denotes liver
T19571 262-271 SO:0000902 denotes transgene
T19570 259-261 PR:000006300 denotes E2
T19569 253-258 NCBITaxon:9606 denotes human
T19568 237-247 GO:0010467 denotes expression
T19567 207-222 UBERON:0007221 denotes neonatal period
T19566 186-189 GO:0016265 denotes die
T19565 183-185 PR:000006300 denotes E2
T19564 165-174 SO:0000902 denotes transgene
T19563 144-146 PR:000006300 denotes E2
T19562 118-122 NCBITaxon:10088 denotes mice
T19561 106-108 PR:000006300 denotes E2
T19560 97-102 UBERON:0002107 denotes liver
T19559 87-89 PR:000006300 denotes E2
T19558 81-86 NCBITaxon:9606 denotes human
T19557 73-80 GO:0010467 denotes express