PMC:1448208 / 28427-28995 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T16481","span":{"begin":567,"end":568},"obj":"."},{"id":"T16480","span":{"begin":566,"end":567},"obj":"-RRB-"},{"id":"T16479","span":{"begin":565,"end":566},"obj":"CD"},{"id":"T16478","span":{"begin":559,"end":564},"obj":"NN"},{"id":"T16477","span":{"begin":558,"end":559},"obj":"-LRB-"},{"id":"T16476","span":{"begin":549,"end":557},"obj":"NNS"},{"id":"T16475","span":{"begin":546,"end":548},"obj":"IN"},{"id":"T16474","span":{"begin":537,"end":545},"obj":"VBN"},{"id":"T16473","span":{"begin":535,"end":537},"obj":","},{"id":"T16472","span":{"begin":531,"end":535},"obj":"NNS"},{"id":"T16471","span":{"begin":526,"end":530},"obj":"NN"},{"id":"T16470","span":{"begin":521,"end":525},"obj":"NN"},{"id":"T16469","span":{"begin":518,"end":520},"obj":"IN"},{"id":"T16468","span":{"begin":508,"end":517},"obj":"NN"},{"id":"T16467","span":{"begin":504,"end":507},"obj":"VBD"},{"id":"T16466","span":{"begin":501,"end":503},"obj":"IN"},{"id":"T16465","span":{"begin":499,"end":501},"obj":","},{"id":"T16464","span":{"begin":495,"end":499},"obj":"NNS"},{"id":"T16463","span":{"begin":493,"end":494},"obj":"NN"},{"id":"T16462","span":{"begin":488,"end":492},"obj":"NN"},{"id":"T16461","span":{"begin":485,"end":487},"obj":"IN"},{"id":"T16460","span":{"begin":472,"end":476},"obj":"VBD"},{"id":"T16459","span":{"begin":462,"end":471},"obj":"NN"},{"id":"T16458","span":{"begin":458,"end":461},"obj":"CC"},{"id":"T16457","span":{"begin":456,"end":458},"obj":","},{"id":"T16456","span":{"begin":447,"end":456},"obj":"NN"},{"id":"T16455","span":{"begin":445,"end":447},"obj":","},{"id":"T16454","span":{"begin":438,"end":445},"obj":"NN"},{"id":"T16453","span":{"begin":435,"end":437},"obj":"IN"},{"id":"T16452","span":{"begin":477,"end":484},"obj":"VBN"},{"id":"T16451","span":{"begin":428,"end":434},"obj":"NNS"},{"id":"T16450","span":{"begin":422,"end":427},"obj":"NN"},{"id":"T16449","span":{"begin":421,"end":568},"obj":"sentence"},{"id":"T16448","span":{"begin":420,"end":421},"obj":"."},{"id":"T16447","span":{"begin":419,"end":420},"obj":"-RRB-"},{"id":"T16446","span":{"begin":417,"end":419},"obj":"NN"},{"id":"T16445","span":{"begin":410,"end":416},"obj":"NN"},{"id":"T16444","span":{"begin":406,"end":409},"obj":"VB"},{"id":"T16443","span":{"begin":405,"end":406},"obj":"-LRB-"},{"id":"T16442","span":{"begin":395,"end":404},"obj":"NNS"},{"id":"T16441","span":{"begin":391,"end":394},"obj":"CC"},{"id":"T16440","span":{"begin":382,"end":390},"obj":"NNS"},{"id":"T16439","span":{"begin":374,"end":381},"obj":"IN"},{"id":"T16438","span":{"begin":361,"end":373},"obj":"JJ"},{"id":"T16437","span":{"begin":341,"end":351},"obj":"JJ"},{"id":"T16436","span":{"begin":352,"end":356},"obj":"NNS"},{"id":"T16435","span":{"begin":337,"end":340},"obj":"DT"},{"id":"T16434","span":{"begin":333,"end":336},"obj":"IN"},{"id":"T16433","span":{"begin":317,"end":318},"obj":"HYPH"},{"id":"T16432","span":{"begin":318,"end":325},"obj":"NN"},{"id":"T16431","span":{"begin":313,"end":317},"obj":"NN"},{"id":"T16430","span":{"begin":326,"end":332},"obj":"NNS"},{"id":"T16429","span":{"begin":309,"end":312},"obj":"DT"},{"id":"T16428","span":{"begin":357,"end":360},"obj":"VBP"},{"id":"T16427","span":{"begin":304,"end":308},"obj":"IN"},{"id":"T16426","span":{"begin":299,"end":303},"obj":"VB"},{"id":"T16425","span":{"begin":298,"end":421},"obj":"sentence"},{"id":"T16424","span":{"begin":297,"end":298},"obj":"."},{"id":"T16423","span":{"begin":289,"end":297},"obj":"VBN"},{"id":"T16422","span":{"begin":277,"end":281},"obj":"NN"},{"id":"T16421","span":{"begin":282,"end":288},"obj":"NNS"},{"id":"T16420","span":{"begin":273,"end":276},"obj":"DT"},{"id":"T16419","span":{"begin":270,"end":272},"obj":"IN"},{"id":"T16418","span":{"begin":266,"end":269},"obj":"DT"},{"id":"T16417","span":{"begin":262,"end":265},"obj":"IN"},{"id":"T16416","span":{"begin":253,"end":261},"obj":"NNS"},{"id":"T16415","span":{"begin":250,"end":252},"obj":"IN"},{"id":"T16414","span":{"begin":241,"end":249},"obj":"VBN"},{"id":"T16413","span":{"begin":232,"end":240},"obj":"JJ"},{"id":"T16412","span":{"begin":218,"end":231},"obj":"RB"},{"id":"T16411","span":{"begin":207,"end":212},"obj":"NNS"},{"id":"T16410","span":{"begin":202,"end":206},"obj":"DT"},{"id":"T16409","span":{"begin":197,"end":201},"obj":"IN"},{"id":"T16408","span":{"begin":192,"end":196},"obj":"NNS"},{"id":"T16407","span":{"begin":188,"end":191},"obj":"IN"},{"id":"T16406","span":{"begin":213,"end":217},"obj":"VBD"},{"id":"T16405","span":{"begin":172,"end":173},"obj":"HYPH"},{"id":"T16404","span":{"begin":173,"end":180},"obj":"NN"},{"id":"T16403","span":{"begin":168,"end":172},"obj":"NN"},{"id":"T16402","span":{"begin":181,"end":187},"obj":"NNS"},{"id":"T16401","span":{"begin":164,"end":167},"obj":"DT"},{"id":"T16400","span":{"begin":163,"end":298},"obj":"sentence"},{"id":"T16399","span":{"begin":162,"end":163},"obj":"."},{"id":"T16398","span":{"begin":155,"end":162},"obj":"NN"},{"id":"T16397","span":{"begin":152,"end":154},"obj":"IN"},{"id":"T16396","span":{"begin":147,"end":151},"obj":"NN"},{"id":"T16395","span":{"begin":141,"end":146},"obj":"JJ"},{"id":"T16394","span":{"begin":138,"end":140},"obj":"IN"},{"id":"T16393","span":{"begin":132,"end":137},"obj":"NN"},{"id":"T16392","span":{"begin":130,"end":131},"obj":"DT"},{"id":"T16391","span":{"begin":127,"end":129},"obj":"IN"},{"id":"T16390","span":{"begin":117,"end":126},"obj":"VBN"},{"id":"T16389","span":{"begin":103,"end":107},"obj":"NN"},{"id":"T16388","span":{"begin":97,"end":102},"obj":"NN"},{"id":"T16387","span":{"begin":108,"end":116},"obj":"NN"},{"id":"T16386","span":{"begin":91,"end":96},"obj":"NN"},{"id":"T16385","span":{"begin":88,"end":90},"obj":"IN"},{"id":"T16384","span":{"begin":80,"end":87},"obj":"NNS"},{"id":"T16383","span":{"begin":76,"end":79},"obj":"DT"},{"id":"T16337","span":{"begin":0,"end":1},"obj":"sentence"},{"id":"T16355","span":{"begin":25,"end":26},"obj":"NNS"},{"id":"T16354","span":{"begin":24,"end":25},"obj":"NNS"},{"id":"T16353","span":{"begin":23,"end":24},"obj":"JJR"},{"id":"T16352","span":{"begin":22,"end":23},"obj":"RB"},{"id":"T16351","span":{"begin":17,"end":21},"obj":"VBD"},{"id":"T16350","span":{"begin":17,"end":26},"obj":"sentence"},{"id":"T16349","span":{"begin":16,"end":17},"obj":"sentence"},{"id":"T16348","span":{"begin":12,"end":16},"obj":"NN"},{"id":"T16347","span":{"begin":10,"end":11},"obj":"NN"},{"id":"T16346","span":{"begin":8,"end":10},"obj":"NN"},{"id":"T16345","span":{"begin":6,"end":7},"obj":"NN"},{"id":"T16344","span":{"begin":6,"end":16},"obj":"sentence"},{"id":"T16343","span":{"begin":4,"end":5},"obj":"VBZ"},{"id":"T16342","span":{"begin":3,"end":4},"obj":"NN"},{"id":"T16341","span":{"begin":2,"end":3},"obj":"NN"},{"id":"T16340","span":{"begin":1,"end":2},"obj":"VBZ"},{"id":"T16339","span":{"begin":1,"end":6},"obj":"sentence"},{"id":"T16338","span":{"begin":0,"end":1},"obj":"NN"},{"id":"T16379","span":{"begin":61,"end":163},"obj":"sentence"},{"id":"T16378","span":{"begin":60,"end":61},"obj":"."},{"id":"T16377","span":{"begin":49,"end":60},"obj":"NN"},{"id":"T16376","span":{"begin":48,"end":49},"obj":"VBN"},{"id":"T16375","span":{"begin":47,"end":48},"obj":"VBD"},{"id":"T16374","span":{"begin":47,"end":61},"obj":"sentence"},{"id":"T16373","span":{"begin":46,"end":47},"obj":"NNS"},{"id":"T16372","span":{"begin":45,"end":46},"obj":"PRP$"},{"id":"T16371","span":{"begin":44,"end":45},"obj":"VBN"},{"id":"T16370","span":{"begin":42,"end":43},"obj":"JJ"},{"id":"T16369","span":{"begin":41,"end":42},"obj":"PRP"},{"id":"T16368","span":{"begin":40,"end":41},"obj":"IN"},{"id":"T16367","span":{"begin":38,"end":40},"obj":"NN"},{"id":"T16366","span":{"begin":37,"end":38},"obj":"IN"},{"id":"T16365","span":{"begin":37,"end":47},"obj":"sentence"},{"id":"T16364","span":{"begin":36,"end":37},"obj":"NNS"},{"id":"T16363","span":{"begin":35,"end":36},"obj":"CC"},{"id":"T16362","span":{"begin":32,"end":34},"obj":"NN"},{"id":"T16361","span":{"begin":31,"end":32},"obj":"IN"},{"id":"T16360","span":{"begin":31,"end":37},"obj":"sentence"},{"id":"T16359","span":{"begin":30,"end":31},"obj":"sentence"},{"id":"T16358","span":{"begin":29,"end":30},"obj":"VBN"},{"id":"T16357","span":{"begin":26,"end":29},"obj":"VBZ"},{"id":"T16356","span":{"begin":26,"end":30},"obj":"sentence"},{"id":"T16382","span":{"begin":70,"end":75},"obj":"VBZ"},{"id":"T16381","span":{"begin":67,"end":69},"obj":"NN"},{"id":"T16380","span":{"begin":62,"end":66},"obj":"NN"}],"relations":[{"id":"R4406","pred":"punct","subj":"T16399","obj":"T16382"},{"id":"R4410","pred":"det","subj":"T16401","obj":"T16402"},{"id":"R4412","pred":"nsubj","subj":"T16402","obj":"T16406"},{"id":"R4413","pred":"compound","subj":"T16403","obj":"T16404"},{"id":"R4414","pred":"compound","subj":"T16404","obj":"T16402"},{"id":"R4416","pred":"punct","subj":"T16405","obj":"T16404"},{"id":"R4420","pred":"prep","subj":"T16407","obj":"T16402"},{"id":"R4424","pred":"pobj","subj":"T16408","obj":"T16407"},{"id":"R4428","pred":"prep","subj":"T16409","obj":"T16408"},{"id":"R4432","pred":"det","subj":"T16410","obj":"T16411"},{"id":"R4436","pred":"pobj","subj":"T16411","obj":"T16409"},{"id":"R4440","pred":"advmod","subj":"T16412","obj":"T16413"},{"id":"R4444","pred":"acomp","subj":"T16413","obj":"T16406"},{"id":"R4448","pred":"prep","subj":"T16414","obj":"T16406"},{"id":"R4451","pred":"prep","subj":"T16415","obj":"T16414"},{"id":"R4453","pred":"pobj","subj":"T16416","obj":"T16415"},{"id":"R4454","pred":"prep","subj":"T16417","obj":"T16416"},{"id":"R4458","pred":"pobj","subj":"T16418","obj":"T16417"},{"id":"R4463","pred":"prep","subj":"T16419","obj":"T16418"},{"id":"R4466","pred":"det","subj":"T16420","obj":"T16421"},{"id":"R4470","pred":"pobj","subj":"T16421","obj":"T16419"},{"id":"R4473","pred":"compound","subj":"T16422","obj":"T16421"},{"id":"R4477","pred":"acl","subj":"T16423","obj":"T16421"},{"id":"R4481","pred":"punct","subj":"T16424","obj":"T16406"},{"id":"R4485","pred":"mark","subj":"T16427","obj":"T16428"},{"id":"R4491","pred":"ccomp","subj":"T16428","obj":"T16426"},{"id":"R4495","pred":"det","subj":"T16429","obj":"T16430"},{"id":"R4497","pred":"nsubj","subj":"T16430","obj":"T16428"},{"id":"R4500","pred":"compound","subj":"T16431","obj":"T16432"},{"id":"R4504","pred":"compound","subj":"T16432","obj":"T16430"},{"id":"R4510","pred":"punct","subj":"T16433","obj":"T16432"},{"id":"R4515","pred":"prep","subj":"T16434","obj":"T16430"},{"id":"R4519","pred":"det","subj":"T16435","obj":"T16436"},{"id":"R4523","pred":"pobj","subj":"T16436","obj":"T16434"},{"id":"R4527","pred":"amod","subj":"T16437","obj":"T16436"},{"id":"R4529","pred":"acomp","subj":"T16438","obj":"T16428"},{"id":"R4530","pred":"prep","subj":"T16439","obj":"T16428"},{"id":"R4353","pred":"nsubj","subj":"T16341","obj":"T16340"},{"id":"R4360","pred":"advmod","subj":"T16352","obj":"T16353"},{"id":"R4361","pred":"acomp","subj":"T16353","obj":"T16351"},{"id":"R4372","pred":"cc","subj":"T16363","obj":"T16362"},{"id":"R4369","pred":"compound","subj":"T16380","obj":"T16381"},{"id":"R4370","pred":"nsubj","subj":"T16381","obj":"T16382"},{"id":"R4371","pred":"det","subj":"T16383","obj":"T16384"},{"id":"R4373","pred":"dobj","subj":"T16384","obj":"T16382"},{"id":"R4374","pred":"prep","subj":"T16385","obj":"T16384"},{"id":"R4375","pred":"pobj","subj":"T16367","obj":"T16366"},{"id":"R4376","pred":"compound","subj":"T16386","obj":"T16387"},{"id":"R4377","pred":"conj","subj":"T16371","obj":"T16370"},{"id":"R4378","pred":"pobj","subj":"T16387","obj":"T16385"},{"id":"R4379","pred":"poss","subj":"T16372","obj":"T16373"},{"id":"R4380","pred":"compound","subj":"T16388","obj":"T16389"},{"id":"R4381","pred":"compound","subj":"T16389","obj":"T16387"},{"id":"R4382","pred":"amod","subj":"T16376","obj":"T16377"},{"id":"R4383","pred":"acl","subj":"T16390","obj":"T16384"},{"id":"R4384","pred":"prep","subj":"T16391","obj":"T16390"},{"id":"R4385","pred":"det","subj":"T16392","obj":"T16393"},{"id":"R4386","pred":"pobj","subj":"T16393","obj":"T16391"},{"id":"R4387","pred":"prep","subj":"T16394","obj":"T16393"},{"id":"R4389","pred":"amod","subj":"T16395","obj":"T16396"},{"id":"R4392","pred":"pobj","subj":"T16396","obj":"T16394"},{"id":"R4396","pred":"prep","subj":"T16397","obj":"T16393"},{"id":"R4400","pred":"pobj","subj":"T16398","obj":"T16397"},{"id":"R4533","pred":"pobj","subj":"T16440","obj":"T16439"},{"id":"R4537","pred":"cc","subj":"T16441","obj":"T16440"},{"id":"R4540","pred":"conj","subj":"T16442","obj":"T16440"},{"id":"R4544","pred":"punct","subj":"T16443","obj":"T16444"},{"id":"R4548","pred":"parataxis","subj":"T16444","obj":"T16428"},{"id":"R4551","pred":"compound","subj":"T16445","obj":"T16446"},{"id":"R4552","pred":"dobj","subj":"T16446","obj":"T16444"},{"id":"R4553","pred":"punct","subj":"T16447","obj":"T16444"},{"id":"R4556","pred":"punct","subj":"T16448","obj":"T16426"},{"id":"R4563","pred":"compound","subj":"T16450","obj":"T16451"},{"id":"R4565","pred":"nsubjpass","subj":"T16451","obj":"T16452"},{"id":"R4568","pred":"prep","subj":"T16453","obj":"T16451"},{"id":"R4574","pred":"pobj","subj":"T16454","obj":"T16453"},{"id":"R4577","pred":"punct","subj":"T16455","obj":"T16454"},{"id":"R4580","pred":"conj","subj":"T16456","obj":"T16454"},{"id":"R4583","pred":"punct","subj":"T16457","obj":"T16456"},{"id":"R4586","pred":"cc","subj":"T16458","obj":"T16456"},{"id":"R4590","pred":"conj","subj":"T16459","obj":"T16456"},{"id":"R4593","pred":"auxpass","subj":"T16460","obj":"T16452"},{"id":"R4597","pred":"prep","subj":"T16461","obj":"T16452"},{"id":"R4601","pred":"compound","subj":"T16462","obj":"T16463"},{"id":"R4605","pred":"compound","subj":"T16463","obj":"T16464"},{"id":"R4609","pred":"pobj","subj":"T16464","obj":"T16461"},{"id":"R4616","pred":"punct","subj":"T16465","obj":"T16452"},{"id":"R4620","pred":"mark","subj":"T16466","obj":"T16467"},{"id":"R4623","pred":"advcl","subj":"T16467","obj":"T16452"},{"id":"R4626","pred":"nsubj","subj":"T16468","obj":"T16467"},{"id":"R4629","pred":"prep","subj":"T16469","obj":"T16468"},{"id":"R4633","pred":"compound","subj":"T16470","obj":"T16471"},{"id":"R4636","pred":"compound","subj":"T16471","obj":"T16472"},{"id":"R4640","pred":"pobj","subj":"T16472","obj":"T16469"},{"id":"R4644","pred":"punct","subj":"T16473","obj":"T16468"},{"id":"R4648","pred":"prep","subj":"T16474","obj":"T16468"},{"id":"R4652","pred":"prep","subj":"T16475","obj":"T16474"},{"id":"R4656","pred":"pobj","subj":"T16476","obj":"T16475"},{"id":"R4658","pred":"punct","subj":"T16477","obj":"T16478"},{"id":"R4661","pred":"parataxis","subj":"T16478","obj":"T16467"},{"id":"R4667","pred":"nummod","subj":"T16479","obj":"T16478"},{"id":"R4671","pred":"punct","subj":"T16480","obj":"T16478"},{"id":"R4672","pred":"punct","subj":"T16481","obj":"T16452"}],"text":"Lines A and 525A were selected for detailed characterization. Fig. 4B shows the results of blood amino acid analysis presented as a ratio of total BCAA to alanine. The BCAA/alanine values for mice from both lines were significantly elevated compared to controls for all of the time points analyzed. Note that the BCAA/alanine values for the transgenic mice are intermediate between controls and knockouts (see Figure 2C). Blood levels of alanine, glutamate, and glutamine were reduced in Line A mice, as was glutamate in Line 525A mice, compared to controls (Table 2)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T15636","span":{"begin":531,"end":535},"obj":"NCBITaxon:10088"},{"id":"T15635","span":{"begin":508,"end":517},"obj":"CHEBI_EXT:glutamate"},{"id":"T15634","span":{"begin":495,"end":499},"obj":"NCBITaxon:10088"},{"id":"T15633","span":{"begin":462,"end":471},"obj":"CHEBI_SO_EXT:glutamine"},{"id":"T15632","span":{"begin":447,"end":456},"obj":"CHEBI_EXT:glutamate"},{"id":"T15631","span":{"begin":438,"end":445},"obj":"CHEBI_SO_EXT:alanine"},{"id":"T15630","span":{"begin":422,"end":427},"obj":"UBERON:0000178"},{"id":"T15629","span":{"begin":352,"end":356},"obj":"NCBITaxon:10088"},{"id":"T15628","span":{"begin":341,"end":351},"obj":"SO_EXT:transgenic_entity"},{"id":"T15627","span":{"begin":318,"end":325},"obj":"CHEBI_SO_EXT:alanine"},{"id":"T15626","span":{"begin":313,"end":317},"obj":"CHEBI:22918"},{"id":"T15625","span":{"begin":192,"end":196},"obj":"NCBITaxon:10088"},{"id":"T15624","span":{"begin":173,"end":180},"obj":"CHEBI_SO_EXT:alanine"},{"id":"T15623","span":{"begin":168,"end":172},"obj":"CHEBI:22918"},{"id":"T15622","span":{"begin":155,"end":162},"obj":"CHEBI_SO_EXT:alanine"},{"id":"T15621","span":{"begin":147,"end":151},"obj":"CHEBI:22918"},{"id":"T15620","span":{"begin":97,"end":107},"obj":"CHEBI_SO_EXT:amino_acid"},{"id":"T15619","span":{"begin":91,"end":96},"obj":"UBERON:0000178"},{"id":"T15618","span":{"begin":44,"end":45},"obj":"GO_EXT:killing"},{"id":"T15617","span":{"begin":10,"end":11},"obj":"UBERON:0000178"},{"id":"T15616","span":{"begin":8,"end":10},"obj":"CHEBI_SO_EXT:alanine"},{"id":"T15615","span":{"begin":6,"end":7},"obj":"CHEBI:22918"},{"id":"T15614","span":{"begin":3,"end":4},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T15613","span":{"begin":0,"end":1},"obj":"PR_EXT:000005308"}],"text":"Lines A and 525A were selected for detailed characterization. Fig. 4B shows the results of blood amino acid analysis presented as a ratio of total BCAA to alanine. The BCAA/alanine values for mice from both lines were significantly elevated compared to controls for all of the time points analyzed. Note that the BCAA/alanine values for the transgenic mice are intermediate between controls and knockouts (see Figure 2C). Blood levels of alanine, glutamate, and glutamine were reduced in Line A mice, as was glutamate in Line 525A mice, compared to controls (Table 2)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T15432","span":{"begin":531,"end":535},"obj":"NCBITaxon:10088"},{"id":"T15423","span":{"begin":10,"end":11},"obj":"UBERON:0000178"},{"id":"T15422","span":{"begin":6,"end":7},"obj":"CHEBI:22918"},{"id":"T15421","span":{"begin":0,"end":1},"obj":"PR:000005308"},{"id":"T15431","span":{"begin":495,"end":499},"obj":"NCBITaxon:10088"},{"id":"T15430","span":{"begin":422,"end":427},"obj":"UBERON:0000178"},{"id":"T15429","span":{"begin":352,"end":356},"obj":"NCBITaxon:10088"},{"id":"T15428","span":{"begin":313,"end":317},"obj":"CHEBI:22918"},{"id":"T15427","span":{"begin":192,"end":196},"obj":"NCBITaxon:10088"},{"id":"T15426","span":{"begin":168,"end":172},"obj":"CHEBI:22918"},{"id":"T15425","span":{"begin":147,"end":151},"obj":"CHEBI:22918"},{"id":"T15424","span":{"begin":91,"end":96},"obj":"UBERON:0000178"}],"text":"Lines A and 525A were selected for detailed characterization. Fig. 4B shows the results of blood amino acid analysis presented as a ratio of total BCAA to alanine. The BCAA/alanine values for mice from both lines were significantly elevated compared to controls for all of the time points analyzed. Note that the BCAA/alanine values for the transgenic mice are intermediate between controls and knockouts (see Figure 2C). Blood levels of alanine, glutamate, and glutamine were reduced in Line A mice, as was glutamate in Line 525A mice, compared to controls (Table 2)."}