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craft-ca-core-ex-dev
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A, BCKDH enzyme activity in liver of newborn wild type control (+/+), heterozygous (+/-), and homozygous (-/-) knockout mice. Enzyme activity was significantly reduced in +/- liver compared to +/+, and was below the level of detection in -/- liver. B, Total BCAA concentrations in blood of mice. Total BCAA represent the sum of leucine, isoleucine, and valine. Total BCAA concentrations in blood from -/- mice were significantly elevated compared to +/+ and +/-. C, Ratio of total BCAA to alanine in blood of mice. This ratio was significantly elevated in -/- mice compared to +/+ and +/- mice. The numbers on the bars indicates the number of mice analyzed. *, Significantly different from +/+ (P \u003c 0.001); **, significantly different from +/+ and +/- (P \u003c 0.001)."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T22732","span":{"begin":49,"end":55},"obj":"NCBITaxon:39107"},{"id":"T22733","span":{"begin":91,"end":96},"obj":"UBERON:0002107"},{"id":"T22734","span":{"begin":183,"end":187},"obj":"NCBITaxon:10088"},{"id":"T22735","span":{"begin":238,"end":243},"obj":"UBERON:0002107"},{"id":"T22736","span":{"begin":305,"end":310},"obj":"UBERON:0002107"},{"id":"T22737","span":{"begin":321,"end":325},"obj":"CHEBI:22918"},{"id":"T22738","span":{"begin":344,"end":349},"obj":"UBERON:0000178"},{"id":"T22739","span":{"begin":353,"end":357},"obj":"NCBITaxon:10088"},{"id":"T22740","span":{"begin":365,"end":369},"obj":"CHEBI:22918"},{"id":"T22741","span":{"begin":430,"end":434},"obj":"CHEBI:22918"},{"id":"T22742","span":{"begin":453,"end":458},"obj":"UBERON:0000178"},{"id":"T22743","span":{"begin":468,"end":472},"obj":"NCBITaxon:10088"},{"id":"T22744","span":{"begin":544,"end":548},"obj":"CHEBI:22918"},{"id":"T22745","span":{"begin":563,"end":568},"obj":"UBERON:0000178"},{"id":"T22746","span":{"begin":572,"end":576},"obj":"NCBITaxon:10088"},{"id":"T22747","span":{"begin":623,"end":627},"obj":"NCBITaxon:10088"},{"id":"T22748","span":{"begin":652,"end":656},"obj":"NCBITaxon:10088"},{"id":"T22749","span":{"begin":706,"end":710},"obj":"NCBITaxon:10088"}],"text":"Biochemical characterization of the classic MSUD murine model. A, BCKDH enzyme activity in liver of newborn wild type control (+/+), heterozygous (+/-), and homozygous (-/-) knockout mice. Enzyme activity was significantly reduced in +/- liver compared to +/+, and was below the level of detection in -/- liver. B, Total BCAA concentrations in blood of mice. Total BCAA represent the sum of leucine, isoleucine, and valine. Total BCAA concentrations in blood from -/- mice were significantly elevated compared to +/+ and +/-. C, Ratio of total BCAA to alanine in blood of mice. This ratio was significantly elevated in -/- mice compared to +/+ and +/- mice. The numbers on the bars indicates the number of mice analyzed. *, Significantly different from +/+ (P \u003c 0.001); **, significantly different from +/+ and +/- (P \u003c 0.001)."}