PMC:1448208 / 1725-2102 JSONTXT

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mice represent important animal models that closely approximate the phenotype of humans with the classic and intermediate forms of MSUD. These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T827","span":{"begin":17,"end":21},"obj":"NCBITaxon:10088"},{"id":"T828","span":{"begin":42,"end":48},"obj":"NCBITaxon:33208"},{"id":"T829","span":{"begin":98,"end":104},"obj":"NCBITaxon:9606"},{"id":"T830","span":{"begin":160,"end":167},"obj":"NCBITaxon:33208"},{"id":"T831","span":{"begin":304,"end":308},"obj":"SO_EXT:0000704"},{"id":"T832","span":{"begin":313,"end":321},"obj":"CL_GO_EXT:cell"},{"id":"T833","span":{"begin":359,"end":368},"obj":"GO:0008152"}],"text":"Conclusion\nThese mice represent important animal models that closely approximate the phenotype of humans with the classic and intermediate forms of MSUD. These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T767","span":{"begin":17,"end":21},"obj":"NCBITaxon:10088"},{"id":"T768","span":{"begin":42,"end":48},"obj":"NCBITaxon:33208"},{"id":"T769","span":{"begin":98,"end":104},"obj":"NCBITaxon:9606"},{"id":"T770","span":{"begin":160,"end":167},"obj":"NCBITaxon:33208"},{"id":"T771","span":{"begin":304,"end":308},"obj":"SO:0000704"},{"id":"T772","span":{"begin":359,"end":368},"obj":"GO:0008152"}],"text":"Conclusion\nThese mice represent important animal models that closely approximate the phenotype of humans with the classic and intermediate forms of MSUD. These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease."}