PMC:1448208 / 16924-17146 JSONTXT

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As illustrated in Fig. 1A and 1B, an E2 Exon 6 specific probe, which is external to the targeting construct, hybridizes to only a ~16 kb BglI restriction fragment from the wild type allele in the parental R1 ES cell line."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T10258","span":{"begin":38,"end":40},"obj":"PR_EXT:000006300"},{"id":"T10259","span":{"begin":41,"end":45},"obj":"SO_EXT:0000147"},{"id":"T10260","span":{"begin":57,"end":62},"obj":"CHEBI_SO_EXT:molecular_probe"},{"id":"T10261","span":{"begin":99,"end":108},"obj":"SO_EXT:engineered_biological_sequence"},{"id":"T10262","span":{"begin":110,"end":120},"obj":"GO:0097617"},{"id":"T10263","span":{"begin":136,"end":137},"obj":"CHEBI_SO_EXT:base"},{"id":"T10264","span":{"begin":143,"end":163},"obj":"SO_EXT:0000412"},{"id":"T10265","span":{"begin":173,"end":182},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T10266","span":{"begin":183,"end":189},"obj":"SO_EXT:0001023"},{"id":"T10267","span":{"begin":209,"end":216},"obj":"CL:0002322"},{"id":"T10268","span":{"begin":212,"end":216},"obj":"CL_GO_EXT:cell"}],"text":" As illustrated in Fig. 1A and 1B, an E2 Exon 6 specific probe, which is external to the targeting construct, hybridizes to only a ~16 kb BglI restriction fragment from the wild type allele in the parental R1 ES cell line."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T10186","span":{"begin":38,"end":40},"obj":"PR:000006300"},{"id":"T10187","span":{"begin":41,"end":45},"obj":"SO:0000147"},{"id":"T10188","span":{"begin":110,"end":120},"obj":"GO:0097617"},{"id":"T10189","span":{"begin":143,"end":163},"obj":"SO:0000412"},{"id":"T10190","span":{"begin":183,"end":189},"obj":"SO:0001023"},{"id":"T10191","span":{"begin":209,"end":216},"obj":"CL:0002322"}],"text":" As illustrated in Fig. 1A and 1B, an E2 Exon 6 specific probe, which is external to the targeting construct, hybridizes to only a ~16 kb BglI restriction fragment from the wild type allele in the parental R1 ES cell line."}