PMC:1448208 / 124-519
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1448208","sourcedb":"PMC","sourceid":"1448208","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1448208","text":"Maple Syrup Urine Disease (MSUD) is an inborn error of metabolism caused by a deficiency of branched-chain keto acid dehydrogenase. MSUD has several clinical phenotypes depending on the degree of enzyme deficiency. Current treatments are not satisfactory and require new approaches to combat this disease. A major hurdle in developing new treatments has been the lack of a suitable animal model.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T853","span":{"begin":0,"end":5},"obj":"NN"},{"id":"T854","span":{"begin":6,"end":11},"obj":"NN"},{"id":"T855","span":{"begin":18,"end":25},"obj":"NN"},{"id":"T856","span":{"begin":12,"end":17},"obj":"NN"},{"id":"T857","span":{"begin":33,"end":35},"obj":"VBZ"},{"id":"T858","span":{"begin":26,"end":27},"obj":"-LRB-"},{"id":"T859","span":{"begin":27,"end":31},"obj":"NN"},{"id":"T860","span":{"begin":31,"end":32},"obj":"-RRB-"},{"id":"T861","span":{"begin":36,"end":38},"obj":"DT"},{"id":"T862","span":{"begin":46,"end":51},"obj":"NN"},{"id":"T863","span":{"begin":39,"end":45},"obj":"JJ"},{"id":"T864","span":{"begin":52,"end":54},"obj":"IN"},{"id":"T865","span":{"begin":55,"end":65},"obj":"NN"},{"id":"T866","span":{"begin":66,"end":72},"obj":"VBN"},{"id":"T867","span":{"begin":73,"end":75},"obj":"IN"},{"id":"T868","span":{"begin":76,"end":77},"obj":"DT"},{"id":"T869","span":{"begin":78,"end":88},"obj":"NN"},{"id":"T870","span":{"begin":89,"end":91},"obj":"IN"},{"id":"T871","span":{"begin":92,"end":100},"obj":"VBN"},{"id":"T872","span":{"begin":101,"end":106},"obj":"NN"},{"id":"T873","span":{"begin":100,"end":101},"obj":"HYPH"},{"id":"T874","span":{"begin":117,"end":130},"obj":"NN"},{"id":"T875","span":{"begin":107,"end":111},"obj":"NN"},{"id":"T876","span":{"begin":112,"end":116},"obj":"NN"},{"id":"T877","span":{"begin":130,"end":131},"obj":"."},{"id":"T878","span":{"begin":131,"end":214},"obj":"sentence"},{"id":"T879","span":{"begin":132,"end":136},"obj":"NN"},{"id":"T880","span":{"begin":137,"end":140},"obj":"VBZ"},{"id":"T881","span":{"begin":141,"end":148},"obj":"JJ"},{"id":"T882","span":{"begin":158,"end":168},"obj":"NNS"},{"id":"T883","span":{"begin":149,"end":157},"obj":"JJ"},{"id":"T884","span":{"begin":169,"end":178},"obj":"VBG"},{"id":"T885","span":{"begin":179,"end":181},"obj":"IN"},{"id":"T886","span":{"begin":182,"end":185},"obj":"DT"},{"id":"T887","span":{"begin":186,"end":192},"obj":"NN"},{"id":"T888","span":{"begin":193,"end":195},"obj":"IN"},{"id":"T889","span":{"begin":196,"end":202},"obj":"NN"},{"id":"T890","span":{"begin":203,"end":213},"obj":"NN"},{"id":"T891","span":{"begin":213,"end":214},"obj":"."},{"id":"T892","span":{"begin":214,"end":305},"obj":"sentence"},{"id":"T893","span":{"begin":215,"end":222},"obj":"JJ"},{"id":"T894","span":{"begin":223,"end":233},"obj":"NNS"},{"id":"T895","span":{"begin":234,"end":237},"obj":"VBP"},{"id":"T896","span":{"begin":238,"end":241},"obj":"RB"},{"id":"T897","span":{"begin":242,"end":254},"obj":"JJ"},{"id":"T898","span":{"begin":255,"end":258},"obj":"CC"},{"id":"T899","span":{"begin":259,"end":266},"obj":"VBP"},{"id":"T900","span":{"begin":267,"end":270},"obj":"JJ"},{"id":"T901","span":{"begin":271,"end":281},"obj":"NNS"},{"id":"T902","span":{"begin":282,"end":284},"obj":"TO"},{"id":"T903","span":{"begin":285,"end":291},"obj":"VB"},{"id":"T904","span":{"begin":292,"end":296},"obj":"DT"},{"id":"T905","span":{"begin":297,"end":304},"obj":"NN"},{"id":"T906","span":{"begin":304,"end":305},"obj":"."},{"id":"T907","span":{"begin":305,"end":395},"obj":"sentence"},{"id":"T908","span":{"begin":306,"end":307},"obj":"DT"},{"id":"T909","span":{"begin":314,"end":320},"obj":"NN"},{"id":"T910","span":{"begin":308,"end":313},"obj":"JJ"},{"id":"T911","span":{"begin":354,"end":358},"obj":"VBN"},{"id":"T912","span":{"begin":321,"end":323},"obj":"IN"},{"id":"T913","span":{"begin":324,"end":334},"obj":"VBG"},{"id":"T914","span":{"begin":335,"end":338},"obj":"JJ"},{"id":"T915","span":{"begin":339,"end":349},"obj":"NNS"},{"id":"T916","span":{"begin":350,"end":353},"obj":"VBZ"},{"id":"T917","span":{"begin":359,"end":362},"obj":"DT"},{"id":"T918","span":{"begin":363,"end":367},"obj":"NN"},{"id":"T919","span":{"begin":368,"end":370},"obj":"IN"},{"id":"T920","span":{"begin":371,"end":372},"obj":"DT"},{"id":"T921","span":{"begin":389,"end":394},"obj":"NN"},{"id":"T922","span":{"begin":373,"end":381},"obj":"JJ"},{"id":"T923","span":{"begin":382,"end":388},"obj":"NN"},{"id":"T924","span":{"begin":394,"end":395},"obj":"."}],"relations":[{"id":"R13","pred":"compound","subj":"T853","obj":"T854"},{"id":"R14","pred":"compound","subj":"T854","obj":"T855"},{"id":"R15","pred":"nsubj","subj":"T855","obj":"T857"},{"id":"R17","pred":"punct","subj":"T858","obj":"T855"},{"id":"R18","pred":"appos","subj":"T859","obj":"T855"},{"id":"R19","pred":"punct","subj":"T860","obj":"T857"},{"id":"R20","pred":"det","subj":"T861","obj":"T862"},{"id":"R21","pred":"attr","subj":"T862","obj":"T857"},{"id":"R23","pred":"prep","subj":"T864","obj":"T862"},{"id":"R24","pred":"pobj","subj":"T865","obj":"T864"},{"id":"R25","pred":"acl","subj":"T866","obj":"T862"},{"id":"R26","pred":"agent","subj":"T867","obj":"T866"},{"id":"R27","pred":"det","subj":"T868","obj":"T869"},{"id":"R28","pred":"pobj","subj":"T869","obj":"T867"},{"id":"R29","pred":"prep","subj":"T870","obj":"T869"},{"id":"R30","pred":"amod","subj":"T871","obj":"T872"},{"id":"R31","pred":"compound","subj":"T872","obj":"T874"},{"id":"R33","pred":"pobj","subj":"T874","obj":"T870"},{"id":"R36","pred":"punct","subj":"T877","obj":"T857"},{"id":"R37","pred":"nsubj","subj":"T879","obj":"T880"},{"id":"R38","pred":"amod","subj":"T881","obj":"T882"},{"id":"R39","pred":"dobj","subj":"T882","obj":"T880"},{"id":"R41","pred":"prep","subj":"T884","obj":"T880"},{"id":"R42","pred":"prep","subj":"T885","obj":"T884"},{"id":"R43","pred":"det","subj":"T886","obj":"T887"},{"id":"R44","pred":"pobj","subj":"T887","obj":"T885"},{"id":"R45","pred":"prep","subj":"T888","obj":"T887"},{"id":"R46","pred":"compound","subj":"T889","obj":"T890"},{"id":"R47","pred":"pobj","subj":"T890","obj":"T888"},{"id":"R48","pred":"punct","subj":"T891","obj":"T880"},{"id":"R49","pred":"amod","subj":"T893","obj":"T894"},{"id":"R50","pred":"nsubj","subj":"T894","obj":"T895"},{"id":"R51","pred":"neg","subj":"T896","obj":"T895"},{"id":"R52","pred":"acomp","subj":"T897","obj":"T895"},{"id":"R53","pred":"cc","subj":"T898","obj":"T895"},{"id":"R54","pred":"conj","subj":"T899","obj":"T895"},{"id":"R55","pred":"amod","subj":"T900","obj":"T901"},{"id":"R56","pred":"dobj","subj":"T901","obj":"T899"},{"id":"R57","pred":"aux","subj":"T902","obj":"T903"},{"id":"R58","pred":"advcl","subj":"T903","obj":"T899"},{"id":"R59","pred":"det","subj":"T904","obj":"T905"},{"id":"R60","pred":"dobj","subj":"T905","obj":"T903"},{"id":"R61","pred":"punct","subj":"T906","obj":"T895"},{"id":"R62","pred":"det","subj":"T908","obj":"T909"},{"id":"R63","pred":"nsubj","subj":"T909","obj":"T911"},{"id":"R65","pred":"prep","subj":"T912","obj":"T909"},{"id":"R66","pred":"pcomp","subj":"T913","obj":"T912"},{"id":"R67","pred":"amod","subj":"T914","obj":"T915"},{"id":"R68","pred":"dobj","subj":"T915","obj":"T913"},{"id":"R69","pred":"aux","subj":"T916","obj":"T911"},{"id":"R70","pred":"det","subj":"T917","obj":"T918"},{"id":"R71","pred":"attr","subj":"T918","obj":"T911"},{"id":"R72","pred":"prep","subj":"T919","obj":"T918"},{"id":"R73","pred":"det","subj":"T920","obj":"T921"},{"id":"R74","pred":"pobj","subj":"T921","obj":"T919"},{"id":"R77","pred":"punct","subj":"T924","obj":"T911"},{"id":"R16","pred":"compound","subj":"T856","obj":"T855"},{"id":"R22","pred":"amod","subj":"T863","obj":"T862"},{"id":"R32","pred":"punct","subj":"T873","obj":"T872"},{"id":"R34","pred":"compound","subj":"T875","obj":"T876"},{"id":"R35","pred":"compound","subj":"T876","obj":"T874"},{"id":"R40","pred":"amod","subj":"T883","obj":"T882"},{"id":"R64","pred":"amod","subj":"T910","obj":"T909"},{"id":"R75","pred":"amod","subj":"T922","obj":"T921"},{"id":"R76","pred":"compound","subj":"T923","obj":"T921"}],"attributes":[{"subj":"T853","pred":"source","obj":"craft-sa-dev"},{"subj":"T854","pred":"source","obj":"craft-sa-dev"},{"subj":"T855","pred":"source","obj":"craft-sa-dev"},{"subj":"T856","pred":"source","obj":"craft-sa-dev"},{"subj":"T857","pred":"source","obj":"craft-sa-dev"},{"subj":"T858","pred":"source","obj":"craft-sa-dev"},{"subj":"T859","pred":"source","obj":"craft-sa-dev"},{"subj":"T860","pred":"source","obj":"craft-sa-dev"},{"subj":"T861","pred":"source","obj":"craft-sa-dev"},{"subj":"T862","pred":"source","obj":"craft-sa-dev"},{"subj":"T863","pred":"source","obj":"craft-sa-dev"},{"subj":"T864","pred":"source","obj":"craft-sa-dev"},{"subj":"T865","pred":"source","obj":"craft-sa-dev"},{"subj":"T866","pred":"source","obj":"craft-sa-dev"},{"subj":"T867","pred":"source","obj":"craft-sa-dev"},{"subj":"T868","pred":"source","obj":"craft-sa-dev"},{"subj":"T869","pred":"source","obj":"craft-sa-dev"},{"subj":"T870","pred":"source","obj":"craft-sa-dev"},{"subj":"T871","pred":"source","obj":"craft-sa-dev"},{"subj":"T872","pred":"source","obj":"craft-sa-dev"},{"subj":"T873","pred":"source","obj":"craft-sa-dev"},{"subj":"T874","pred":"source","obj":"craft-sa-dev"},{"subj":"T875","pred":"source","obj":"craft-sa-dev"},{"subj":"T876","pred":"source","obj":"craft-sa-dev"},{"subj":"T877","pred":"source","obj":"craft-sa-dev"},{"subj":"T878","pred":"source","obj":"craft-sa-dev"},{"subj":"T879","pred":"source","obj":"craft-sa-dev"},{"subj":"T880","pred":"source","obj":"craft-sa-dev"},{"subj":"T881","pred":"source","obj":"craft-sa-dev"},{"subj":"T882","pred":"source","obj":"craft-sa-dev"},{"subj":"T883","pred":"source","obj":"craft-sa-dev"},{"subj":"T884","pred":"source","obj":"craft-sa-dev"},{"subj":"T885","pred":"source","obj":"craft-sa-dev"},{"subj":"T886","pred":"source","obj":"craft-sa-dev"},{"subj":"T887","pred":"source","obj":"craft-sa-dev"},{"subj":"T888","pred":"source","obj":"craft-sa-dev"},{"subj":"T889","pred":"source","obj":"craft-sa-dev"},{"subj":"T890","pred":"source","obj":"craft-sa-dev"},{"subj":"T891","pred":"source","obj":"craft-sa-dev"},{"subj":"T892","pred":"source","obj":"craft-sa-dev"},{"subj":"T893","pred":"source","obj":"craft-sa-dev"},{"subj":"T894","pred":"source","obj":"craft-sa-dev"},{"subj":"T895","pred":"source","obj":"craft-sa-dev"},{"subj":"T896","pred":"source","obj":"craft-sa-dev"},{"subj":"T897","pred":"source","obj":"craft-sa-dev"},{"subj":"T898","pred":"source","obj":"craft-sa-dev"},{"subj":"T899","pred":"source","obj":"craft-sa-dev"},{"subj":"T900","pred":"source","obj":"craft-sa-dev"},{"subj":"T901","pred":"source","obj":"craft-sa-dev"},{"subj":"T902","pred":"source","obj":"craft-sa-dev"},{"subj":"T903","pred":"source","obj":"craft-sa-dev"},{"subj":"T904","pred":"source","obj":"craft-sa-dev"},{"subj":"T905","pred":"source","obj":"craft-sa-dev"},{"subj":"T906","pred":"source","obj":"craft-sa-dev"},{"subj":"T907","pred":"source","obj":"craft-sa-dev"},{"subj":"T908","pred":"source","obj":"craft-sa-dev"},{"subj":"T909","pred":"source","obj":"craft-sa-dev"},{"subj":"T910","pred":"source","obj":"craft-sa-dev"},{"subj":"T911","pred":"source","obj":"craft-sa-dev"},{"subj":"T912","pred":"source","obj":"craft-sa-dev"},{"subj":"T913","pred":"source","obj":"craft-sa-dev"},{"subj":"T914","pred":"source","obj":"craft-sa-dev"},{"subj":"T915","pred":"source","obj":"craft-sa-dev"},{"subj":"T916","pred":"source","obj":"craft-sa-dev"},{"subj":"T917","pred":"source","obj":"craft-sa-dev"},{"subj":"T918","pred":"source","obj":"craft-sa-dev"},{"subj":"T919","pred":"source","obj":"craft-sa-dev"},{"subj":"T920","pred":"source","obj":"craft-sa-dev"},{"subj":"T921","pred":"source","obj":"craft-sa-dev"},{"subj":"T922","pred":"source","obj":"craft-sa-dev"},{"subj":"T923","pred":"source","obj":"craft-sa-dev"},{"subj":"T924","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T776","span":{"begin":0,"end":5},"obj":"NCBITaxon:4022"},{"id":"T777","span":{"begin":12,"end":17},"obj":"UBERON:0001088"},{"id":"T778","span":{"begin":55,"end":65},"obj":"GO:0008152"},{"id":"T779","span":{"begin":107,"end":116},"obj":"CHEBI:25754"},{"id":"T780","span":{"begin":196,"end":202},"obj":"CHEBI_GO_SO_EXT:enzyme"},{"id":"T781","span":{"begin":382,"end":388},"obj":"NCBITaxon:33208"}],"attributes":[{"subj":"T776","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T777","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T778","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T779","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T780","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T781","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T729","span":{"begin":0,"end":5},"obj":"NCBITaxon:4022"},{"id":"T730","span":{"begin":12,"end":17},"obj":"UBERON:0001088"},{"id":"T731","span":{"begin":55,"end":65},"obj":"GO:0008152"},{"id":"T732","span":{"begin":107,"end":116},"obj":"CHEBI:25754"},{"id":"T733","span":{"begin":382,"end":388},"obj":"NCBITaxon:33208"}],"attributes":[{"subj":"T729","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T730","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T731","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T732","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T733","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#93c7ec","default":true},{"id":"craft-ca-core-ex-dev","color":"#e1ec93"},{"id":"craft-ca-core-dev","color":"#dd93ec"}]}]}}