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PMC:1448208 / 113-2102 JSONTXT

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Id Subject Object Predicate Lexical cue
T850 0-10 sentence denotes Background
T851 0-10 NN denotes Background
T852 10-142 sentence denotes Maple Syrup Urine Disease (MSUD) is an inborn error of metabolism caused by a deficiency of branched-chain keto acid dehydrogenase.
T853 11-16 NN denotes Maple
T854 17-22 NN denotes Syrup
T855 29-36 NN denotes Disease
T856 23-28 NN denotes Urine
T857 44-46 VBZ denotes is
T858 37-38 -LRB- denotes (
T859 38-42 NN denotes MSUD
T860 42-43 -RRB- denotes )
T861 47-49 DT denotes an
T862 57-62 NN denotes error
T863 50-56 JJ denotes inborn
T864 63-65 IN denotes of
T865 66-76 NN denotes metabolism
T866 77-83 VBN denotes caused
T867 84-86 IN denotes by
T868 87-88 DT denotes a
T869 89-99 NN denotes deficiency
T870 100-102 IN denotes of
T871 103-111 VBN denotes branched
T872 112-117 NN denotes chain
T873 111-112 HYPH denotes -
T874 128-141 NN denotes dehydrogenase
T875 118-122 NN denotes keto
T876 123-127 NN denotes acid
T877 141-142 . denotes .
T878 142-225 sentence denotes MSUD has several clinical phenotypes depending on the degree of enzyme deficiency.
T879 143-147 NN denotes MSUD
T880 148-151 VBZ denotes has
T881 152-159 JJ denotes several
T882 169-179 NNS denotes phenotypes
T883 160-168 JJ denotes clinical
T884 180-189 VBG denotes depending
T885 190-192 IN denotes on
T886 193-196 DT denotes the
T887 197-203 NN denotes degree
T888 204-206 IN denotes of
T889 207-213 NN denotes enzyme
T890 214-224 NN denotes deficiency
T891 224-225 . denotes .
T892 225-316 sentence denotes Current treatments are not satisfactory and require new approaches to combat this disease.
T893 226-233 JJ denotes Current
T894 234-244 NNS denotes treatments
T895 245-248 VBP denotes are
T896 249-252 RB denotes not
T897 253-265 JJ denotes satisfactory
T898 266-269 CC denotes and
T899 270-277 VBP denotes require
T900 278-281 JJ denotes new
T901 282-292 NNS denotes approaches
T902 293-295 TO denotes to
T903 296-302 VB denotes combat
T904 303-307 DT denotes this
T905 308-315 NN denotes disease
T906 315-316 . denotes .
T907 316-406 sentence denotes A major hurdle in developing new treatments has been the lack of a suitable animal model.
T908 317-318 DT denotes A
T909 325-331 NN denotes hurdle
T910 319-324 JJ denotes major
T911 365-369 VBN denotes been
T912 332-334 IN denotes in
T913 335-345 VBG denotes developing
T914 346-349 JJ denotes new
T915 350-360 NNS denotes treatments
T916 361-364 VBZ denotes has
T917 370-373 DT denotes the
T918 374-378 NN denotes lack
T919 379-381 IN denotes of
T920 382-383 DT denotes a
T921 400-405 NN denotes model
T922 384-392 JJ denotes suitable
T923 393-399 NN denotes animal
T924 405-406 . denotes .
T925 406-415 sentence denotes Methods
T926 408-415 NNS denotes Methods
T927 415-624 sentence denotes To create a murine model of classic MSUD, we used gene targeting and embryonic stem cell technologies to create a mouse line that lacked a functional E2 subunit gene of branched-chain keto acid dehydrogenase.
T928 416-418 TO denotes To
T929 419-425 VB denotes create
T930 461-465 VBD denotes used
T931 426-427 DT denotes a
T932 435-440 NN denotes model
T933 428-434 JJ denotes murine
T934 441-443 IN denotes of
T935 444-451 JJ denotes classic
T936 452-456 NN denotes MSUD
T937 456-458 , denotes ,
T938 458-460 PRP denotes we
T939 466-470 NN denotes gene
T940 471-480 NN denotes targeting
T941 481-484 CC denotes and
T942 485-494 JJ denotes embryonic
T943 500-504 NN denotes cell
T944 495-499 NN denotes stem
T945 505-517 NNS denotes technologies
T946 518-520 TO denotes to
T947 521-527 VB denotes create
T948 528-529 DT denotes a
T949 536-540 NN denotes line
T950 530-535 NN denotes mouse
T951 541-545 WDT denotes that
T952 546-552 VBD denotes lacked
T953 553-554 DT denotes a
T954 577-581 NN denotes gene
T955 555-565 JJ denotes functional
T956 566-568 NN denotes E2
T957 569-576 NN denotes subunit
T958 582-584 IN denotes of
T959 585-593 VBN denotes branched
T960 594-599 NN denotes chain
T961 593-594 HYPH denotes -
T962 610-623 NN denotes dehydrogenase
T963 600-604 NN denotes keto
T964 605-609 NN denotes acid
T965 623-624 . denotes .
T966 624-756 sentence denotes To create a murine model of intermediate MSUD, we used transgenic technology to express a human E2 cDNA on the knockout background.
T967 625-627 TO denotes To
T968 628-634 VB denotes create
T969 675-679 VBD denotes used
T970 635-636 DT denotes a
T971 644-649 NN denotes model
T972 637-643 JJ denotes murine
T973 650-652 IN denotes of
T974 653-665 JJ denotes intermediate
T975 666-670 NN denotes MSUD
T976 670-672 , denotes ,
T977 672-674 PRP denotes we
T978 680-690 JJ denotes transgenic
T979 691-701 NN denotes technology
T980 702-704 TO denotes to
T981 705-712 VB denotes express
T982 713-714 DT denotes a
T983 724-728 NN denotes cDNA
T984 715-720 JJ denotes human
T985 721-723 NN denotes E2
T986 729-731 IN denotes on
T987 732-735 DT denotes the
T988 745-755 NN denotes background
T989 736-744 NN denotes knockout
T990 755-756 . denotes .
T991 756-851 sentence denotes Mice of both models were characterized at the molecular, biochemical, and whole animal levels.
T992 757-761 NNS denotes Mice
T993 782-795 VBN denotes characterized
T994 762-764 IN denotes of
T995 765-769 DT denotes both
T996 770-776 NNS denotes models
T997 777-781 VBD denotes were
T998 796-798 IN denotes at
T999 799-802 DT denotes the
T1000 844-850 NNS denotes levels
T1001 803-812 JJ denotes molecular
T1002 812-814 , denotes ,
T1003 814-825 JJ denotes biochemical
T1004 825-827 , denotes ,
T1005 827-830 CC denotes and
T1006 831-836 JJ denotes whole
T1007 837-843 NN denotes animal
T1008 850-851 . denotes .
T1009 851-860 sentence denotes Results
T1010 853-860 NNS denotes Results
T1011 860-993 sentence denotes By disrupting the E2 subunit gene of branched-chain keto acid dehydrogenase, we created a gene knockout mouse model of classic MSUD.
T1012 861-863 IN denotes By
T1013 941-948 VBD denotes created
T1014 864-874 VBG denotes disrupting
T1015 875-878 DT denotes the
T1016 890-894 NN denotes gene
T1017 879-881 NN denotes E2
T1018 882-889 NN denotes subunit
T1019 895-897 IN denotes of
T1020 898-906 VBN denotes branched
T1021 907-912 NN denotes chain
T1022 906-907 HYPH denotes -
T1023 923-936 NN denotes dehydrogenase
T1024 913-917 NN denotes keto
T1025 918-922 NN denotes acid
T1026 936-938 , denotes ,
T1027 938-940 PRP denotes we
T1028 949-950 DT denotes a
T1029 971-976 NN denotes model
T1030 951-955 NN denotes gene
T1031 956-964 NN denotes knockout
T1032 965-970 NN denotes mouse
T1033 977-979 IN denotes of
T1034 980-987 JJ denotes classic
T1035 988-992 NN denotes MSUD
T1036 992-993 . denotes .
T1037 993-1168 sentence denotes The homozygous knockout mice lacked branched-chain keto acid dehydrogenase activity, E2 immunoreactivity, and had a 3-fold increase in circulating branched-chain amino acids.
T1038 994-997 DT denotes The
T1039 1018-1022 NNS denotes mice
T1040 998-1008 JJ denotes homozygous
T1041 1009-1017 NN denotes knockout
T1042 1023-1029 VBD denotes lacked
T1043 1030-1038 VBN denotes branched
T1044 1039-1044 NN denotes chain
T1045 1038-1039 HYPH denotes -
T1046 1055-1068 NN denotes dehydrogenase
T1047 1045-1049 NN denotes keto
T1048 1050-1054 NN denotes acid
T1049 1069-1077 NN denotes activity
T1050 1077-1079 , denotes ,
T1051 1079-1081 NN denotes E2
T1052 1082-1098 NN denotes immunoreactivity
T1053 1098-1100 , denotes ,
T1054 1100-1103 CC denotes and
T1055 1104-1107 VBD denotes had
T1056 1108-1109 DT denotes a
T1057 1117-1125 NN denotes increase
T1058 1110-1111 CD denotes 3
T1059 1111-1112 HYPH denotes -
T1060 1112-1116 JJ denotes fold
T1061 1126-1128 IN denotes in
T1062 1129-1140 VBG denotes circulating
T1063 1162-1167 NNS denotes acids
T1064 1141-1149 VBN denotes branched
T1065 1150-1155 NN denotes chain
T1066 1149-1150 HYPH denotes -
T1067 1156-1161 NN denotes amino
T1068 1167-1168 . denotes .
T1069 1168-1229 sentence denotes These metabolic derangements resulted in neonatal lethality.
T1070 1169-1174 DT denotes These
T1071 1185-1197 NNS denotes derangements
T1072 1175-1184 JJ denotes metabolic
T1073 1198-1206 VBD denotes resulted
T1074 1207-1209 IN denotes in
T1075 1210-1218 JJ denotes neonatal
T1076 1219-1228 NN denotes lethality
T1077 1228-1229 . denotes .
T1078 1229-1349 sentence denotes Transgenic expression of a human E2 cDNA in the liver of the E2 knockout animals produced a model of intermediate MSUD.
T1079 1230-1240 JJ denotes Transgenic
T1080 1241-1251 NN denotes expression
T1081 1311-1319 VBD denotes produced
T1082 1252-1254 IN denotes of
T1083 1255-1256 DT denotes a
T1084 1266-1270 NN denotes cDNA
T1085 1257-1262 JJ denotes human
T1086 1263-1265 NN denotes E2
T1087 1271-1273 IN denotes in
T1088 1274-1277 DT denotes the
T1089 1278-1283 NN denotes liver
T1090 1284-1286 IN denotes of
T1091 1287-1290 DT denotes the
T1092 1303-1310 NNS denotes animals
T1093 1291-1293 NN denotes E2
T1094 1294-1302 NN denotes knockout
T1095 1320-1321 DT denotes a
T1096 1322-1327 NN denotes model
T1097 1328-1330 IN denotes of
T1098 1331-1343 JJ denotes intermediate
T1099 1344-1348 NN denotes MSUD
T1100 1348-1349 . denotes .
T1101 1349-1610 sentence denotes Branched-chain keto acid dehydrogenase activity was 5–6% of normal and was sufficient to allow survival, but was insufficient to normalize circulating branched-chain amino acids levels, which were intermediate between wildtype and the classic MSUD mouse model.
T1102 1350-1358 VBN denotes Branched
T1103 1359-1364 NN denotes chain
T1104 1358-1359 HYPH denotes -
T1105 1375-1388 NN denotes dehydrogenase
T1106 1365-1369 NN denotes keto
T1107 1370-1374 NN denotes acid
T1108 1389-1397 NN denotes activity
T1109 1398-1401 VBD denotes was
T1110 1402-1403 CD denotes 5
T1111 1404-1405 CD denotes 6
T1112 1403-1404 SYM denotes –
T1113 1405-1406 NN denotes %
T1114 1407-1409 IN denotes of
T1115 1410-1416 JJ denotes normal
T1116 1417-1420 CC denotes and
T1117 1421-1424 VBD denotes was
T1118 1425-1435 JJ denotes sufficient
T1119 1436-1438 TO denotes to
T1120 1439-1444 VB denotes allow
T1121 1445-1453 NN denotes survival
T1122 1453-1455 , denotes ,
T1123 1455-1458 CC denotes but
T1124 1459-1462 VBD denotes was
T1125 1463-1475 JJ denotes insufficient
T1126 1476-1478 TO denotes to
T1127 1489-1500 VBG denotes circulating
T1128 1479-1488 VB denotes normalize
T1129 1501-1509 VBN denotes branched
T1130 1510-1515 NN denotes chain
T1131 1509-1510 HYPH denotes -
T1132 1522-1527 NNS denotes acids
T1133 1516-1521 NN denotes amino
T1134 1528-1534 NNS denotes levels
T1135 1534-1536 , denotes ,
T1136 1536-1541 WDT denotes which
T1137 1542-1546 VBD denotes were
T1138 1547-1559 JJ denotes intermediate
T1139 1560-1567 IN denotes between
T1140 1568-1576 NN denotes wildtype
T1141 1577-1580 CC denotes and
T1142 1581-1584 DT denotes the
T1143 1604-1609 NN denotes model
T1144 1585-1592 JJ denotes classic
T1145 1593-1597 NN denotes MSUD
T1146 1598-1603 NN denotes mouse
T1147 1609-1610 . denotes .
T1148 1610-1622 sentence denotes Conclusion
T1149 1612-1622 NN denotes Conclusion
T1150 1622-1765 sentence denotes These mice represent important animal models that closely approximate the phenotype of humans with the classic and intermediate forms of MSUD.
T1151 1623-1628 DT denotes These
T1152 1629-1633 NNS denotes mice
T1153 1634-1643 VBP denotes represent
T1154 1644-1653 JJ denotes important
T1155 1661-1667 NNS denotes models
T1156 1654-1660 NN denotes animal
T1157 1668-1672 WDT denotes that
T1158 1681-1692 VBP denotes approximate
T1159 1673-1680 RB denotes closely
T1160 1693-1696 DT denotes the
T1161 1697-1706 NN denotes phenotype
T1162 1707-1709 IN denotes of
T1163 1710-1716 NNS denotes humans
T1164 1717-1721 IN denotes with
T1165 1722-1725 DT denotes the
T1166 1751-1756 NNS denotes forms
T1167 1726-1733 JJ denotes classic
T1168 1734-1737 CC denotes and
T1169 1738-1750 JJ denotes intermediate
T1170 1757-1759 IN denotes of
T1171 1760-1764 NN denotes MSUD
T1172 1764-1765 . denotes .
T1173 1765-1989 sentence denotes These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease.
T1174 1766-1771 DT denotes These
T1175 1772-1779 NNS denotes animals
T1176 1780-1787 VBP denotes provide
T1177 1788-1794 JJ denotes useful
T1178 1795-1801 NNS denotes models
T1179 1802-1804 TO denotes to
T1180 1813-1825 VB denotes characterize
T1181 1805-1812 RB denotes further
T1182 1826-1829 DT denotes the
T1183 1830-1842 NN denotes pathogenesis
T1184 1843-1845 IN denotes of
T1185 1846-1850 NN denotes MSUD
T1186 1850-1852 , denotes ,
T1187 1852-1854 RB denotes as
T1188 1860-1862 IN denotes as
T1189 1855-1859 RB denotes well
T1190 1863-1869 NNS denotes models
T1191 1870-1872 TO denotes to
T1192 1873-1877 VB denotes test
T1193 1878-1883 JJ denotes novel
T1194 1896-1906 NNS denotes strategies
T1195 1884-1895 JJ denotes therapeutic
T1196 1906-1908 , denotes ,
T1197 1908-1912 JJ denotes such
T1198 1913-1915 IN denotes as
T1199 1916-1920 NN denotes gene
T1200 1934-1943 NNS denotes therapies
T1201 1921-1924 CC denotes and
T1202 1925-1933 JJ denotes cellular
T1203 1943-1945 , denotes ,
T1204 1945-1947 TO denotes to
T1205 1948-1953 VB denotes treat
T1206 1954-1958 DT denotes this
T1207 1981-1988 NN denotes disease
T1208 1959-1970 VBG denotes devastating
T1209 1971-1980 JJ denotes metabolic
T1210 1988-1989 . denotes .
R13 T853 T854 compound Maple,Syrup
R14 T854 T855 compound Syrup,Disease
R15 T855 T857 nsubj Disease,is
R17 T858 T855 punct (,Disease
R18 T859 T855 appos MSUD,Disease
R19 T860 T857 punct ),is
R20 T861 T862 det an,error
R21 T862 T857 attr error,is
R23 T864 T862 prep of,error
R24 T865 T864 pobj metabolism,of
R25 T866 T862 acl caused,error
R26 T867 T866 agent by,caused
R27 T868 T869 det a,deficiency
R28 T869 T867 pobj deficiency,by
R29 T870 T869 prep of,deficiency
R30 T871 T872 amod branched,chain
R31 T872 T874 compound chain,dehydrogenase
R33 T874 T870 pobj dehydrogenase,of
R36 T877 T857 punct .,is
R37 T879 T880 nsubj MSUD,has
R38 T881 T882 amod several,phenotypes
R39 T882 T880 dobj phenotypes,has
R41 T884 T880 prep depending,has
R42 T885 T884 prep on,depending
R43 T886 T887 det the,degree
R44 T887 T885 pobj degree,on
R45 T888 T887 prep of,degree
R46 T889 T890 compound enzyme,deficiency
R47 T890 T888 pobj deficiency,of
R48 T891 T880 punct .,has
R49 T893 T894 amod Current,treatments
R50 T894 T895 nsubj treatments,are
R51 T896 T895 neg not,are
R52 T897 T895 acomp satisfactory,are
R53 T898 T895 cc and,are
R54 T899 T895 conj require,are
R55 T900 T901 amod new,approaches
R56 T901 T899 dobj approaches,require
R57 T902 T903 aux to,combat
R58 T903 T899 advcl combat,require
R59 T904 T905 det this,disease
R60 T905 T903 dobj disease,combat
R61 T906 T895 punct .,are
R62 T908 T909 det A,hurdle
R63 T909 T911 nsubj hurdle,been
R65 T912 T909 prep in,hurdle
R66 T913 T912 pcomp developing,in
R67 T914 T915 amod new,treatments
R68 T915 T913 dobj treatments,developing
R69 T916 T911 aux has,been
R70 T917 T918 det the,lack
R71 T918 T911 attr lack,been
R72 T919 T918 prep of,lack
R73 T920 T921 det a,model
R74 T921 T919 pobj model,of
R77 T924 T911 punct .,been
R78 T928 T929 aux To,create
R79 T929 T930 advcl create,used
R80 T931 T932 det a,model
R81 T932 T929 dobj model,create
R83 T934 T932 prep of,model
R84 T935 T936 amod classic,MSUD
R85 T936 T934 pobj MSUD,of
R86 T937 T930 punct ", ",used
R87 T938 T930 nsubj we,used
R88 T939 T940 compound gene,targeting
R89 T940 T930 dobj targeting,used
R90 T941 T940 cc and,targeting
R91 T942 T943 amod embryonic,cell
R92 T943 T945 compound cell,technologies
R94 T945 T940 conj technologies,targeting
R95 T946 T947 aux to,create
R96 T947 T930 advcl create,used
R97 T948 T949 det a,line
R98 T949 T947 dobj line,create
R100 T951 T952 dep that,lacked
R101 T952 T949 relcl lacked,line
R102 T953 T954 det a,gene
R103 T954 T952 dobj gene,lacked
R107 T958 T954 prep of,gene
R108 T959 T960 amod branched,chain
R109 T960 T962 compound chain,dehydrogenase
R111 T962 T958 pobj dehydrogenase,of
R114 T965 T930 punct .,used
R115 T967 T968 aux To,create
R116 T968 T969 advcl create,used
R117 T970 T971 det a,model
R118 T971 T968 dobj model,create
R120 T973 T971 prep of,model
R121 T974 T975 amod intermediate,MSUD
R122 T975 T973 pobj MSUD,of
R123 T976 T969 punct ", ",used
R124 T977 T969 nsubj we,used
R125 T978 T979 amod transgenic,technology
R126 T979 T969 dobj technology,used
R127 T980 T981 aux to,express
R128 T981 T969 advcl express,used
R129 T982 T983 det a,cDNA
R130 T983 T981 dobj cDNA,express
R133 T986 T983 prep on,cDNA
R134 T987 T988 det the,background
R135 T988 T986 pobj background,on
R137 T990 T969 punct .,used
R138 T992 T993 nsubjpass Mice,characterized
R139 T994 T992 prep of,Mice
R140 T995 T996 det both,models
R141 T996 T994 pobj models,of
R142 T997 T993 auxpass were,characterized
R143 T998 T993 prep at,characterized
R144 T999 T1000 det the,levels
R145 T1000 T998 pobj levels,at
R153 T1008 T993 punct .,characterized
R154 T1012 T1013 prep By,created
R155 T1014 T1012 pcomp disrupting,By
R156 T1015 T1016 det the,gene
R157 T1016 T1014 dobj gene,disrupting
R160 T1019 T1016 prep of,gene
R161 T1020 T1021 amod branched,chain
R162 T1021 T1023 compound chain,dehydrogenase
R164 T1023 T1019 pobj dehydrogenase,of
R167 T1026 T1013 punct ", ",created
R168 T1027 T1013 nsubj we,created
R169 T1028 T1029 det a,model
R170 T1029 T1013 dobj model,created
R174 T1033 T1029 prep of,model
R175 T1034 T1035 amod classic,MSUD
R176 T1035 T1033 pobj MSUD,of
R177 T1036 T1013 punct .,created
R178 T1038 T1039 det The,mice
R179 T1039 T1042 nsubj mice,lacked
R182 T1043 T1044 amod branched,chain
R183 T1044 T1046 compound chain,dehydrogenase
R185 T1046 T1049 compound dehydrogenase,activity
R188 T1049 T1042 dobj activity,lacked
R189 T1050 T1049 punct ", ",activity
R190 T1051 T1052 compound E2,immunoreactivity
R191 T1052 T1049 appos immunoreactivity,activity
R192 T1053 T1042 punct ", ",lacked
R193 T1054 T1042 cc and,lacked
R194 T1055 T1042 conj had,lacked
R195 T1056 T1057 det a,increase
R196 T1057 T1055 dobj increase,had
R200 T1061 T1057 prep in,increase
R201 T1062 T1063 amod circulating,acids
R202 T1063 T1061 pobj acids,in
R204 T1065 T1063 compound chain,acids
R205 T1066 T1065 punct -,chain
R207 T1068 T1042 punct .,lacked
R208 T1070 T1071 det These,derangements
R209 T1071 T1073 nsubj derangements,resulted
R211 T1074 T1073 prep in,resulted
R212 T1075 T1076 amod neonatal,lethality
R213 T1076 T1074 pobj lethality,in
R214 T1077 T1073 punct .,resulted
R215 T1079 T1080 amod Transgenic,expression
R216 T1080 T1081 nsubj expression,produced
R217 T1082 T1080 prep of,expression
R218 T1083 T1084 det a,cDNA
R219 T1084 T1082 pobj cDNA,of
R222 T1087 T1080 prep in,expression
R223 T1088 T1089 det the,liver
R224 T1089 T1087 pobj liver,in
R225 T1090 T1089 prep of,liver
R226 T1091 T1092 det the,animals
R227 T1092 T1090 pobj animals,of
R230 T1095 T1096 det a,model
R231 T1096 T1081 dobj model,produced
R232 T1097 T1096 prep of,model
R233 T1098 T1099 amod intermediate,MSUD
R234 T1099 T1097 pobj MSUD,of
R235 T1100 T1081 punct .,produced
R236 T1102 T1103 amod Branched,chain
R237 T1103 T1105 compound chain,dehydrogenase
R239 T1105 T1108 compound dehydrogenase,activity
R242 T1108 T1109 nsubj activity,was
R243 T1110 T1111 quantmod 5,6
R244 T1111 T1113 nummod 6,%
R246 T1113 T1109 attr %,was
R247 T1114 T1113 prep of,%
R248 T1115 T1114 amod normal,of
R249 T1116 T1109 cc and,was
R250 T1117 T1109 conj was,was
R251 T1118 T1117 acomp sufficient,was
R252 T1119 T1120 aux to,allow
R253 T1120 T1118 xcomp allow,sufficient
R254 T1121 T1120 dobj survival,allow
R255 T1122 T1109 punct ", ",was
R256 T1123 T1109 cc but,was
R257 T1124 T1109 conj was,was
R258 T1125 T1124 acomp insufficient,was
R259 T1126 T1127 aux to,circulating
R260 T1127 T1125 xcomp circulating,insufficient
R262 T1129 T1130 amod branched,chain
R263 T1130 T1132 compound chain,acids
R265 T1132 T1134 compound acids,levels
R267 T1134 T1127 dobj levels,circulating
R268 T1135 T1134 punct ", ",levels
R269 T1136 T1137 dep which,were
R270 T1137 T1134 relcl were,levels
R271 T1138 T1137 acomp intermediate,were
R272 T1139 T1137 prep between,were
R273 T1140 T1139 pobj wildtype,between
R274 T1141 T1140 cc and,wildtype
R275 T1142 T1143 det the,model
R276 T1143 T1140 conj model,wildtype
R280 T1147 T1109 punct .,was
R281 T1151 T1152 det These,mice
R282 T1152 T1153 nsubj mice,represent
R283 T1154 T1155 amod important,models
R284 T1155 T1153 dobj models,represent
R286 T1157 T1158 dep that,approximate
R287 T1158 T1155 relcl approximate,models
R289 T1160 T1161 det the,phenotype
R290 T1161 T1158 dobj phenotype,approximate
R291 T1162 T1161 prep of,phenotype
R292 T1163 T1162 pobj humans,of
R293 T1164 T1163 prep with,humans
R294 T1165 T1166 det the,forms
R295 T1166 T1164 pobj forms,with
R299 T1170 T1166 prep of,forms
R300 T1171 T1170 pobj MSUD,of
R301 T1172 T1153 punct .,represent
R302 T1174 T1175 det These,animals
R303 T1175 T1176 nsubj animals,provide
R304 T1177 T1178 amod useful,models
R305 T1178 T1176 dobj models,provide
R306 T1179 T1180 aux to,characterize
R307 T1180 T1178 advcl characterize,models
R309 T1182 T1183 det the,pathogenesis
R310 T1183 T1180 dobj pathogenesis,characterize
R311 T1184 T1183 prep of,pathogenesis
R312 T1185 T1184 pobj MSUD,of
R313 T1186 T1178 punct ", ",models
R314 T1187 T1188 advmod as,as
R315 T1188 T1178 cc as,models
R317 T1190 T1178 conj models,models
R318 T1191 T1192 aux to,test
R319 T1192 T1190 advcl test,models
R320 T1193 T1194 amod novel,strategies
R321 T1194 T1192 dobj strategies,test
R323 T1196 T1194 punct ", ",strategies
R324 T1197 T1198 amod such,as
R325 T1198 T1194 prep as,strategies
R326 T1199 T1200 nmod gene,therapies
R327 T1200 T1198 pobj therapies,as
R330 T1203 T1200 punct ", ",therapies
R331 T1204 T1205 aux to,treat
R332 T1205 T1200 advcl treat,therapies
R333 T1206 T1207 det this,disease
R334 T1207 T1205 dobj disease,treat
R337 T1210 T1176 punct .,provide
R16 T856 T855 compound Urine,Disease
R22 T863 T862 amod inborn,error
R32 T873 T872 punct -,chain
R34 T875 T876 compound keto,acid
R35 T876 T874 compound acid,dehydrogenase
R40 T883 T882 amod clinical,phenotypes
R64 T910 T909 amod major,hurdle
R75 T922 T921 amod suitable,model
R76 T923 T921 compound animal,model
R82 T933 T932 amod murine,model
R93 T944 T943 compound stem,cell
R99 T950 T949 compound mouse,line
R104 T955 T954 amod functional,gene
R105 T956 T954 compound E2,gene
R106 T957 T954 compound subunit,gene
R110 T961 T960 punct -,chain
R112 T963 T964 compound keto,acid
R113 T964 T962 compound acid,dehydrogenase
R119 T972 T971 amod murine,model
R131 T984 T983 amod human,cDNA
R132 T985 T983 compound E2,cDNA
R136 T989 T988 compound knockout,background
R146 T1001 T1000 amod molecular,levels
R147 T1002 T1001 punct ", ",molecular
R148 T1003 T1001 conj biochemical,molecular
R149 T1004 T1003 punct ", ",biochemical
R150 T1005 T1003 cc and,biochemical
R151 T1006 T1007 amod whole,animal
R152 T1007 T1003 conj animal,biochemical
R158 T1017 T1016 compound E2,gene
R159 T1018 T1016 compound subunit,gene
R163 T1022 T1021 punct -,chain
R165 T1024 T1025 compound keto,acid
R166 T1025 T1023 compound acid,dehydrogenase
R171 T1030 T1031 compound gene,knockout
R172 T1031 T1029 compound knockout,model
R173 T1032 T1029 compound mouse,model
R180 T1040 T1039 amod homozygous,mice
R181 T1041 T1039 compound knockout,mice
R184 T1045 T1044 punct -,chain
R186 T1047 T1048 compound keto,acid
R187 T1048 T1046 compound acid,dehydrogenase
R197 T1058 T1057 nummod 3,increase
R198 T1059 T1058 punct -,3
R199 T1060 T1058 amod fold,3
R203 T1064 T1065 amod branched,chain
R206 T1067 T1063 compound amino,acids
R210 T1072 T1071 amod metabolic,derangements
R220 T1085 T1084 amod human,cDNA
R221 T1086 T1084 compound E2,cDNA
R228 T1093 T1092 compound E2,animals
R229 T1094 T1092 compound knockout,animals
R238 T1104 T1103 punct -,chain
R240 T1106 T1107 compound keto,acid
R241 T1107 T1105 compound acid,dehydrogenase
R245 T1112 T1111 punct –,6
R261 T1128 T1127 aux normalize,circulating
R264 T1131 T1130 punct -,chain
R266 T1133 T1132 compound amino,acids
R277 T1144 T1143 amod classic,model
R278 T1145 T1143 compound MSUD,model
R279 T1146 T1143 compound mouse,model
R285 T1156 T1155 compound animal,models
R288 T1159 T1158 advmod closely,approximate
R296 T1167 T1166 amod classic,forms
R297 T1168 T1167 cc and,classic
R298 T1169 T1167 conj intermediate,classic
R308 T1181 T1180 advmod further,characterize
R316 T1189 T1188 advmod well,as
R322 T1195 T1194 amod therapeutic,strategies
R328 T1201 T1199 cc and,gene
R329 T1202 T1199 conj cellular,gene
R335 T1208 T1207 amod devastating,disease
R336 T1209 T1207 amod metabolic,disease

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T776 11-16 NCBITaxon:4022 denotes Maple
T777 23-28 UBERON:0001088 denotes Urine
T778 66-76 GO:0008152 denotes metabolism
T779 118-127 CHEBI:25754 denotes keto acid
T780 207-213 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T781 393-399 NCBITaxon:33208 denotes animal
T782 428-434 NCBITaxon:39107 denotes murine
T783 466-470 SO_EXT:0000704 denotes gene
T784 485-494 UBERON:0000922 denotes embryonic
T785 485-504 CL:0002322 denotes embryonic stem cell
T786 500-504 CL_GO_EXT:cell denotes cell
T787 530-535 NCBITaxon:10088 denotes mouse
T788 566-576 PR_EXT:000006300 denotes E2 subunit
T789 577-581 SO_EXT:0000704 denotes gene
T790 600-609 CHEBI:25754 denotes keto acid
T791 637-643 NCBITaxon:39107 denotes murine
T792 680-690 SO_EXT:transgenic_entity denotes transgenic
T793 705-712 GO:0010467 denotes express
T794 715-720 NCBITaxon:9606 denotes human
T795 721-723 PR_EXT:000006300 denotes E2
T796 724-728 SO_EXT:cDNA denotes cDNA
T797 757-761 NCBITaxon:10088 denotes Mice
T798 803-812 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T799 814-825 CHEBI_EXT:biochemical denotes biochemical
T800 837-843 NCBITaxon:33208 denotes animal
T801 879-889 PR_EXT:000006300 denotes E2 subunit
T802 890-894 SO_EXT:0000704 denotes gene
T803 913-922 CHEBI:25754 denotes keto acid
T804 951-955 SO_EXT:0000704 denotes gene
T805 965-970 NCBITaxon:10088 denotes mouse
T806 1018-1022 NCBITaxon:10088 denotes mice
T807 1045-1054 CHEBI:25754 denotes keto acid
T808 1079-1081 PR_EXT:000006300 denotes E2
T809 1141-1167 CHEBI:22918 denotes branched-chain amino acids
T810 1156-1167 CHEBI_SO_EXT:amino_acid denotes amino acids
T811 1175-1184 GO:0008152 denotes metabolic
T812 1210-1218 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T813 1219-1228 GO_EXT:fatality_or_lethality denotes lethality
T814 1230-1240 SO_EXT:transgenic_entity denotes Transgenic
T815 1241-1251 GO:0010467 denotes expression
T816 1257-1262 NCBITaxon:9606 denotes human
T817 1263-1265 PR_EXT:000006300 denotes E2
T818 1266-1270 SO_EXT:cDNA denotes cDNA
T819 1278-1283 UBERON:0002107 denotes liver
T820 1291-1293 PR_EXT:000006300 denotes E2
T821 1303-1310 NCBITaxon:33208 denotes animals
T822 1365-1374 CHEBI:25754 denotes keto acid
T823 1501-1527 CHEBI:22918 denotes branched-chain amino acids
T824 1516-1527 CHEBI_SO_EXT:amino_acid denotes amino acids
T825 1568-1576 SO_EXT:wild_type_entity_or_quality denotes wildtype
T826 1598-1603 NCBITaxon:10088 denotes mouse
T827 1629-1633 NCBITaxon:10088 denotes mice
T828 1654-1660 NCBITaxon:33208 denotes animal
T829 1710-1716 NCBITaxon:9606 denotes humans
T830 1772-1779 NCBITaxon:33208 denotes animals
T831 1916-1920 SO_EXT:0000704 denotes gene
T832 1925-1933 CL_GO_EXT:cell denotes cellular
T833 1971-1980 GO:0008152 denotes metabolic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T729 11-16 NCBITaxon:4022 denotes Maple
T730 23-28 UBERON:0001088 denotes Urine
T731 66-76 GO:0008152 denotes metabolism
T732 118-127 CHEBI:25754 denotes keto acid
T733 393-399 NCBITaxon:33208 denotes animal
T734 428-434 NCBITaxon:39107 denotes murine
T735 466-470 SO:0000704 denotes gene
T736 485-494 UBERON:0000922 denotes embryonic
T737 485-504 CL:0002322 denotes embryonic stem cell
T738 530-535 NCBITaxon:10088 denotes mouse
T739 566-576 PR:000006300 denotes E2 subunit
T740 577-581 SO:0000704 denotes gene
T741 600-609 CHEBI:25754 denotes keto acid
T742 637-643 NCBITaxon:39107 denotes murine
T743 705-712 GO:0010467 denotes express
T744 715-720 NCBITaxon:9606 denotes human
T745 721-723 PR:000006300 denotes E2
T746 757-761 NCBITaxon:10088 denotes Mice
T747 837-843 NCBITaxon:33208 denotes animal
T748 879-889 PR:000006300 denotes E2 subunit
T749 890-894 SO:0000704 denotes gene
T750 913-922 CHEBI:25754 denotes keto acid
T751 951-955 SO:0000704 denotes gene
T752 965-970 NCBITaxon:10088 denotes mouse
T753 1018-1022 NCBITaxon:10088 denotes mice
T754 1045-1054 CHEBI:25754 denotes keto acid
T755 1079-1081 PR:000006300 denotes E2
T756 1141-1167 CHEBI:22918 denotes branched-chain amino acids
T757 1175-1184 GO:0008152 denotes metabolic
T758 1241-1251 GO:0010467 denotes expression
T759 1257-1262 NCBITaxon:9606 denotes human
T760 1263-1265 PR:000006300 denotes E2
T761 1278-1283 UBERON:0002107 denotes liver
T762 1291-1293 PR:000006300 denotes E2
T763 1303-1310 NCBITaxon:33208 denotes animals
T764 1365-1374 CHEBI:25754 denotes keto acid
T765 1501-1527 CHEBI:22918 denotes branched-chain amino acids
T766 1598-1603 NCBITaxon:10088 denotes mouse
T767 1629-1633 NCBITaxon:10088 denotes mice
T768 1654-1660 NCBITaxon:33208 denotes animal
T769 1710-1716 NCBITaxon:9606 denotes humans
T770 1772-1779 NCBITaxon:33208 denotes animals
T771 1916-1920 SO:0000704 denotes gene
T772 1971-1980 GO:0008152 denotes metabolic