PMC:1447668 / 42657-43018
Annnotations
bionlp-st-ge-2016-reference-tees
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T18701 | 116-120 | Protein | denotes | CD4+ |
| T18702 | 283-288 | Protein | denotes | NF-κB |
| T18703 | 296-300 | Protein | denotes | CREB |
| T18704 | 332-337 | Protein | denotes | Foxp3 |
| T18705 | 301-311 | Positive_regulation | denotes | activation |
| T18706 | 301-311 | Positive_regulation | denotes | activation |
| T18707 | 324-331 | Negative_regulation | denotes | inhibit |
| T18708 | 324-331 | Negative_regulation | denotes | inhibit |
| T18709 | 338-348 | Gene_expression | denotes | expression |
| T18710 | 324-331 | Negative_regulation | denotes | inhibit |
| R14084 | T18702 | T18705 | themeOf | NF-κB,activation |
| R14085 | T18703 | T18706 | themeOf | CREB,activation |
| R14086 | T18704 | T18709 | themeOf | Foxp3,expression |
| R14087 | T18705 | T18707 | themeOf | activation,inhibit |
| R14088 | T18706 | T18708 | themeOf | activation,inhibit |
| R14089 | T18709 | T18710 | themeOf | expression,inhibit |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14437 | 0-361 | Sentence | denotes | However, observing that this inhibitory effect is not absolute, a low level of viral gene expression may persist in CD4+ T cells (in particular regulatory T cells, which are known reservoirs of HIV-1 and HTLV-I) and result in the accumulation of viral proteins that either stimulate NF-κB and/or CREB activation or directly inhibit Foxp3 expression or function. |
| T234 | 0-361 | Sentence | denotes | However, observing that this inhibitory effect is not absolute, a low level of viral gene expression may persist in CD4+ T cells (in particular regulatory T cells, which are known reservoirs of HIV-1 and HTLV-I) and result in the accumulation of viral proteins that either stimulate NF-κB and/or CREB activation or directly inhibit Foxp3 expression or function. |
pmc-enju-pas
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17261 | 0-7 | RB | denotes | However |
| T17262 | 7-8 | -COMMA- | denotes | , |
| T17263 | 9-18 | VB | denotes | observing |
| T17264 | 19-23 | IN | denotes | that |
| T17265 | 24-28 | DT | denotes | this |
| T17266 | 29-39 | JJ | denotes | inhibitory |
| T17267 | 40-46 | NN | denotes | effect |
| T17268 | 47-49 | VB | denotes | is |
| T17269 | 50-53 | RB | denotes | not |
| T17270 | 54-62 | JJ | denotes | absolute |
| T17271 | 62-63 | -COMMA- | denotes | , |
| T17272 | 64-65 | DT | denotes | a |
| T17273 | 66-69 | JJ | denotes | low |
| T17274 | 70-75 | NN | denotes | level |
| T17275 | 76-78 | IN | denotes | of |
| T17276 | 79-84 | JJ | denotes | viral |
| T17277 | 85-89 | NN | denotes | gene |
| T17278 | 90-100 | NN | denotes | expression |
| T17279 | 101-104 | MD | denotes | may |
| T17280 | 105-112 | VB | denotes | persist |
| T17281 | 113-115 | IN | denotes | in |
| T17282 | 116-120 | JJ | denotes | CD4+ |
| T17283 | 121-122 | NN | denotes | T |
| T17284 | 123-128 | NN | denotes | cells |
| T17285 | 129-130 | -LRB- | denotes | ( |
| T17286 | 130-132 | IN | denotes | in |
| T17287 | 133-143 | JJ | denotes | particular |
| T17288 | 144-154 | JJ | denotes | regulatory |
| T17289 | 155-156 | NN | denotes | T |
| T17290 | 157-162 | NN | denotes | cells |
| T17291 | 162-163 | -COMMA- | denotes | , |
| T17292 | 164-169 | WDT | denotes | which |
| T17293 | 170-173 | VB | denotes | are |
| T17294 | 174-179 | VB | denotes | known |
| T17295 | 180-190 | NN | denotes | reservoirs |
| T17296 | 191-193 | IN | denotes | of |
| T17297 | 194-199 | NN | denotes | HIV-1 |
| T17298 | 200-203 | CC | denotes | and |
| T17299 | 204-210 | NN | denotes | HTLV-I |
| T17300 | 210-211 | -RRB- | denotes | ) |
| T17301 | 212-215 | CC | denotes | and |
| T17302 | 216-222 | VB | denotes | result |
| T17303 | 223-225 | IN | denotes | in |
| T17304 | 226-229 | DT | denotes | the |
| T17305 | 230-242 | NN | denotes | accumulation |
| T17306 | 243-245 | IN | denotes | of |
| T17307 | 246-251 | JJ | denotes | viral |
| T17308 | 252-260 | NN | denotes | proteins |
| T17309 | 261-265 | WDT | denotes | that |
| T17310 | 266-272 | CC | denotes | either |
| T17311 | 273-282 | VB | denotes | stimulate |
| T17312 | 283-288 | NN | denotes | NF-κB |
| T17313 | 289-295 | CC | denotes | and/or |
| T17314 | 296-300 | NN | denotes | CREB |
| T17315 | 301-311 | NN | denotes | activation |
| T17316 | 312-314 | CC | denotes | or |
| T17317 | 315-323 | RB | denotes | directly |
| T17318 | 324-331 | VB | denotes | inhibit |
| T17319 | 332-337 | NN | denotes | Foxp3 |
| T17320 | 338-348 | NN | denotes | expression |
| T17321 | 349-351 | CC | denotes | or |
| T17322 | 352-360 | NN | denotes | function |
| R13381 | T17267 | T17265 | arg1Of | effect,this |
| R13382 | T17267 | T17266 | arg1Of | effect,inhibitory |
| R13383 | T17267 | T17268 | arg1Of | effect,is |
| R13384 | T17267 | T17270 | arg1Of | effect,absolute |
| R13385 | T17268 | T17263 | arg2Of | is,observing |
| R13386 | T17268 | T17264 | arg1Of | is,that |
| R13387 | T17268 | T17269 | arg1Of | is,not |
| R13388 | T17270 | T17268 | arg2Of | absolute,is |
| R13392 | T17274 | T17263 | arg1Of | level,observing |
| R13393 | T17274 | T17272 | arg1Of | level,a |
| R13394 | T17274 | T17273 | arg1Of | level,low |
| R13395 | T17274 | T17275 | arg1Of | level,of |
| R13396 | T17274 | T17279 | arg1Of | level,may |
| R13397 | T17274 | T17280 | arg1Of | level,persist |
| R13398 | T17274 | T17302 | arg1Of | level,result |
| R13400 | T17278 | T17275 | arg2Of | expression,of |
| R13401 | T17278 | T17276 | arg1Of | expression,viral |
| R13402 | T17278 | T17277 | arg1Of | expression,gene |
| R13403 | T17280 | T17279 | arg2Of | persist,may |
| R13404 | T17280 | T17281 | arg1Of | persist,in |
| R13405 | T17280 | T17301 | arg1Of | persist,and |
| R13408 | T17284 | T17281 | arg2Of | cells,in |
| R13409 | T17284 | T17282 | arg1Of | cells,CD4+ |
| R13410 | T17284 | T17283 | arg1Of | cells,T |
| R13411 | T17284 | T17285 | arg1Of | cells,( |
| R13413 | T17287 | T17286 | arg2Of | particular,in |
| R13415 | T17290 | T17285 | arg2Of | cells,( |
| R13416 | T17290 | T17286 | arg1Of | cells,in |
| R13417 | T17290 | T17288 | arg1Of | cells,regulatory |
| R13418 | T17290 | T17289 | arg1Of | cells,T |
| R13419 | T17290 | T17291 | arg1Of | cells,"," |
| R13420 | T17290 | T17292 | arg1Of | cells,which |
| R13421 | T17290 | T17293 | arg1Of | cells,are |
| R13424 | T17295 | T17293 | arg2Of | reservoirs,are |
| R13425 | T17295 | T17294 | arg2Of | reservoirs,known |
| R13426 | T17295 | T17296 | arg1Of | reservoirs,of |
| R13427 | T17297 | T17298 | arg1Of | HIV-1,and |
| R13428 | T17298 | T17296 | arg2Of | and,of |
| R13429 | T17299 | T17298 | arg2Of | HTLV-I,and |
| R13430 | T17300 | T17285 | arg3Of | ),( |
| R13431 | T17301 | T17261 | arg1Of | and,However |
| R13432 | T17301 | T17262 | arg1Of | and,"," |
| R13433 | T17301 | T17263 | modOf | and,observing |
| R13434 | T17301 | T17271 | arg1Of | and,"," |
| R13435 | T17302 | T17301 | arg2Of | result,and |
| R13436 | T17302 | T17303 | arg1Of | result,in |
| R13438 | T17305 | T17303 | arg2Of | accumulation,in |
| R13439 | T17305 | T17304 | arg1Of | accumulation,the |
| R13440 | T17305 | T17306 | arg1Of | accumulation,of |
| R13443 | T17308 | T17306 | arg2Of | proteins,of |
| R13444 | T17308 | T17307 | arg1Of | proteins,viral |
| R13445 | T17308 | T17309 | arg1Of | proteins,that |
| R13446 | T17308 | T17311 | arg1Of | proteins,stimulate |
| R13447 | T17308 | T17318 | arg1Of | proteins,inhibit |
| R13448 | T17311 | T17316 | arg1Of | stimulate,or |
| R13449 | T17312 | T17313 | arg1Of | NF-κB,and/or |
| R13452 | T17314 | T17313 | arg2Of | CREB,and/or |
| R13453 | T17315 | T17311 | arg2Of | activation,stimulate |
| R13454 | T17315 | T17312 | arg1Of | activation,NF-κB |
| R13455 | T17315 | T17314 | arg1Of | activation,CREB |
| R13456 | T17316 | T17310 | arg1Of | or,either |
| R13459 | T17318 | T17316 | arg2Of | inhibit,or |
| R13460 | T17318 | T17317 | arg1Of | inhibit,directly |
| R13463 | T17320 | T17321 | arg1Of | expression,or |
| R13464 | T17321 | T17318 | arg2Of | or,inhibit |
| R13465 | T17321 | T17319 | arg1Of | or,Foxp3 |
| R13466 | T17322 | T17321 | arg2Of | function,or |
bionlp-st-ge-2016-spacy-parsed
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T15836 | 0-7 | RB | denotes | However |
| T15837 | 7-8 | , | denotes | , |
| T15838 | 9-18 | VBG | denotes | observing |
| T15839 | 19-23 | IN | denotes | that |
| T15840 | 24-28 | DT | denotes | this |
| T15841 | 29-39 | JJ | denotes | inhibitory |
| T15842 | 40-46 | NN | denotes | effect |
| T15843 | 47-49 | VBZ | denotes | is |
| T15844 | 50-53 | RB | denotes | not |
| T15845 | 54-62 | JJ | denotes | absolute |
| T15846 | 62-63 | , | denotes | , |
| T15847 | 64-65 | DT | denotes | a |
| T15848 | 66-69 | JJ | denotes | low |
| T15849 | 70-75 | NN | denotes | level |
| T15850 | 76-78 | IN | denotes | of |
| T15851 | 79-84 | JJ | denotes | viral |
| T15852 | 85-89 | NN | denotes | gene |
| T15853 | 90-100 | NN | denotes | expression |
| T15854 | 101-104 | MD | denotes | may |
| T15855 | 105-112 | VB | denotes | persist |
| T15856 | 113-115 | IN | denotes | in |
| T15857 | 116-119 | CD | denotes | CD4 |
| T15858 | 119-120 | CD | denotes | + |
| T15859 | 121-122 | NNP | denotes | T |
| T15860 | 123-128 | NNS | denotes | cells |
| T15861 | 129-130 | -LRB- | denotes | ( |
| T15862 | 130-132 | IN | denotes | in |
| T15863 | 133-143 | JJ | denotes | particular |
| T15864 | 144-154 | JJ | denotes | regulatory |
| T15865 | 155-156 | NNP | denotes | T |
| T15866 | 157-162 | NNS | denotes | cells |
| T15867 | 162-163 | , | denotes | , |
| T15868 | 164-169 | WDT | denotes | which |
| T15869 | 170-173 | VBP | denotes | are |
| T15870 | 174-179 | VBN | denotes | known |
| T15871 | 180-190 | NNS | denotes | reservoirs |
| T15872 | 191-193 | IN | denotes | of |
| T15873 | 194-199 | NNP | denotes | HIV-1 |
| T15874 | 200-203 | CC | denotes | and |
| T15875 | 204-210 | NNP | denotes | HTLV-I |
| T15876 | 210-211 | -RRB- | denotes | ) |
| T15877 | 212-215 | CC | denotes | and |
| T15878 | 216-222 | VB | denotes | result |
| T15879 | 223-225 | IN | denotes | in |
| T15880 | 226-229 | DT | denotes | the |
| T15881 | 230-242 | NN | denotes | accumulation |
| T15882 | 243-245 | IN | denotes | of |
| T15883 | 246-251 | JJ | denotes | viral |
| T15884 | 252-260 | NNS | denotes | proteins |
| T15885 | 261-265 | WDT | denotes | that |
| T15886 | 266-272 | RB | denotes | either |
| T15887 | 273-282 | VBP | denotes | stimulate |
| T15888 | 283-288 | NNP | denotes | NF-κB |
| T15889 | 289-295 | CC | denotes | and/or |
| T15890 | 296-300 | NNP | denotes | CREB |
| T15891 | 301-311 | NN | denotes | activation |
| T15892 | 312-314 | CC | denotes | or |
| T15893 | 315-323 | RB | denotes | directly |
| T15894 | 324-331 | VB | denotes | inhibit |
| T15895 | 332-337 | JJ | denotes | Foxp3 |
| T15896 | 338-348 | NN | denotes | expression |
| T15897 | 349-351 | CC | denotes | or |
| T15898 | 352-360 | NN | denotes | function |
| T15899 | 360-361 | . | denotes | . |
| R11997 | T15836 | T15855 | advmod | However,persist |
| R11998 | T15837 | T15855 | punct | ",",persist |
| R11999 | T15838 | T15855 | advcl | observing,persist |
| R12000 | T15839 | T15843 | mark | that,is |
| R12001 | T15840 | T15842 | det | this,effect |
| R12002 | T15841 | T15842 | amod | inhibitory,effect |
| R12003 | T15842 | T15843 | nsubj | effect,is |
| R12004 | T15843 | T15838 | ccomp | is,observing |
| R12005 | T15844 | T15843 | neg | not,is |
| R12006 | T15845 | T15843 | acomp | absolute,is |
| R12007 | T15846 | T15855 | punct | ",",persist |
| R12008 | T15847 | T15849 | det | a,level |
| R12009 | T15848 | T15849 | amod | low,level |
| R12010 | T15849 | T15855 | nsubj | level,persist |
| R12011 | T15850 | T15849 | prep | of,level |
| R12012 | T15851 | T15853 | amod | viral,expression |
| R12013 | T15852 | T15853 | compound | gene,expression |
| R12014 | T15853 | T15850 | pobj | expression,of |
| R12015 | T15854 | T15855 | aux | may,persist |
| R12016 | T15855 | T15855 | ROOT | persist,persist |
| R12017 | T15856 | T15855 | prep | in,persist |
| R12018 | T15857 | T15860 | nummod | CD4,cells |
| R12019 | T15858 | T15860 | nummod | +,cells |
| R12020 | T15859 | T15860 | compound | T,cells |
| R12021 | T15860 | T15856 | pobj | cells,in |
| R12022 | T15861 | T15860 | punct | (,cells |
| R12023 | T15862 | T15860 | prep | in,cells |
| R12024 | T15863 | T15866 | amod | particular,cells |
| R12025 | T15864 | T15866 | amod | regulatory,cells |
| R12026 | T15865 | T15866 | compound | T,cells |
| R12027 | T15866 | T15862 | pobj | cells,in |
| R12028 | T15867 | T15860 | punct | ",",cells |
| R12029 | T15868 | T15870 | nsubjpass | which,known |
| R12030 | T15869 | T15870 | auxpass | are,known |
| R12031 | T15870 | T15871 | amod | known,reservoirs |
| R12032 | T15871 | T15860 | conj | reservoirs,cells |
| R12033 | T15872 | T15871 | prep | of,reservoirs |
| R12034 | T15873 | T15872 | pobj | HIV-1,of |
| R12035 | T15874 | T15873 | cc | and,HIV-1 |
| R12036 | T15875 | T15873 | conj | HTLV-I,HIV-1 |
| R12037 | T15876 | T15855 | punct | ),persist |
| R12038 | T15877 | T15855 | cc | and,persist |
| R12039 | T15878 | T15855 | conj | result,persist |
| R12040 | T15879 | T15878 | prep | in,result |
| R12041 | T15880 | T15881 | det | the,accumulation |
| R12042 | T15881 | T15879 | pobj | accumulation,in |
| R12043 | T15882 | T15881 | prep | of,accumulation |
| R12044 | T15883 | T15884 | amod | viral,proteins |
| R12045 | T15884 | T15882 | pobj | proteins,of |
| R12046 | T15885 | T15887 | nsubj | that,stimulate |
| R12047 | T15886 | T15887 | preconj | either,stimulate |
| R12048 | T15887 | T15884 | relcl | stimulate,proteins |
| R12049 | T15888 | T15887 | dobj | NF-κB,stimulate |
| R12050 | T15889 | T15888 | cc | and/or,NF-κB |
| R12051 | T15890 | T15891 | compound | CREB,activation |
| R12052 | T15891 | T15887 | dobj | activation,stimulate |
| R12053 | T15892 | T15891 | cc | or,activation |
| R12054 | T15893 | T15894 | advmod | directly,inhibit |
| R12055 | T15894 | T15887 | conj | inhibit,stimulate |
| R12056 | T15895 | T15896 | amod | Foxp3,expression |
| R12057 | T15896 | T15894 | dobj | expression,inhibit |
| R12058 | T15897 | T15896 | cc | or,expression |
| R12059 | T15898 | T15896 | conj | function,expression |
| R12060 | T15899 | T15855 | punct | .,persist |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14460 | 85-100 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T14468 | 79-100 | http://purl.obolibrary.org/obo/GO_0019080 | denotes | viral gene expression |
| T14482 | 296-311 | http://purl.obolibrary.org/obo/GO_0032793 | denotes | CREB activation |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17663 | 123-128 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T17664 | 157-162 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
events-check-again
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T18497 | 116-119 | Protein | denotes | CD4 |
| T18498 | 324-331 | Negative_regulation | denotes | inhibit |
| T18499 | 332-337 | Protein | denotes | Foxp3 |
| T18500 | 338-348 | Gene_expression | denotes | expression |
| R13979 | T18499 | T18500 | themeOf | Foxp3,expression |
| R13980 | T18500 | T18498 | themeOf | expression,inhibit |
bionlp-st-ge-2016-reference
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14390 | 116-119 | Protein | denotes | CD4 |
| T14391 | 324-331 | Negative_regulation | denotes | inhibit |
| T14392 | 332-337 | Protein | denotes | Foxp3 |
| T14393 | 338-348 | Gene_expression | denotes | expression |
| R10646 | T14392 | T14393 | themeOf | Foxp3,expression |
| R10647 | T14393 | T14391 | themeOf | expression,inhibit |
bionlp-st-ge-2016-uniprot
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17589 | 116-119 | P01730 | denotes | CD4 |
| T17590 | 296-300 | Q02930 | denotes | CREB |
| T17591 | 296-300 | O43889 | denotes | CREB |
| T17592 | 296-300 | P16220 | denotes | CREB |
| T17593 | 296-300 | Q8TEY5 | denotes | CREB |
| T17594 | 296-300 | P15336 | denotes | CREB |
| T17595 | 296-300 | P18848 | denotes | CREB |
| T17596 | 332-337 | Q9BZS1 | denotes | Foxp3 |
test2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14249 | 338-348 | Gene_expression | denotes | expression |
| T14246 | 116-119 | Protein | denotes | CD4 |
| T14247 | 324-331 | Negative_regulation | denotes | inhibit |
| T14248 | 332-337 | Protein | denotes | Foxp3 |
| R10578 | T14248 | T14249 | themeOf | Foxp3,expression |
| R10579 | T14249 | T14247 | themeOf | expression,inhibit |