PMC:1440874 / 6836-8116 JSONTXT

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We therefore adopted a conditional strategy for targeting exon 18 (Figure 2) and recovered two clones in which exon 18 has been flanked by loxP recognition sites for the Cre recombinase (Atrx flox allele in Figure 2A) (Figure 2B). This allele also contains a loxP-flanked MC1-neor cassette in intron 17 (Figure 2A). 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