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PMC:1440874 / 49080-50060 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T10927 0-3 NN denotes ATR
T10928 4-5 NN denotes X
T10929 3-4 HYPH denotes -
T10930 6-14 NN denotes syndrome
T10931 15-17 VBZ denotes is
T10932 18-21 DT denotes the
T10933 42-49 NN denotes disease
T10934 22-27 JJ denotes first
T10935 28-33 JJ denotes human
T10936 34-41 JJ denotes genetic
T10937 50-55 VBN denotes known
T10938 56-58 TO denotes to
T10939 62-68 VBN denotes caused
T10940 59-61 VB denotes be
T10941 69-71 IN denotes by
T10942 72-81 NNS denotes mutations
T10943 82-84 IN denotes in
T10944 85-86 DT denotes a
T10945 109-115 NN denotes factor
T10946 87-96 NN denotes chromatin
T10947 97-108 NN denotes remodelling
T10948 115-116 . denotes .
T10949 116-219 sentence denotes At present we do not know how ATRX influences gene expression or what effect it has on cell behaviour.
T10950 117-119 IN denotes At
T10951 138-142 VB denotes know
T10952 120-127 JJ denotes present
T10953 128-130 PRP denotes we
T10954 131-133 VBP denotes do
T10955 134-137 RB denotes not
T10956 143-146 WRB denotes how
T10957 152-162 VBZ denotes influences
T10958 147-151 NN denotes ATRX
T10959 163-167 NN denotes gene
T10960 168-178 NN denotes expression
T10961 179-181 CC denotes or
T10962 182-186 WDT denotes what
T10963 187-193 NN denotes effect
T10964 197-200 VBZ denotes has
T10965 194-196 PRP denotes it
T10966 201-203 IN denotes on
T10967 204-208 NN denotes cell
T10968 209-218 NN denotes behaviour
T10969 218-219 . denotes .
T10970 219-395 sentence denotes Nevertheless, we have previously noted that none of the natural mutations causing ATR-X syndrome are nulls, which suggests that it plays a critical role in normal development.
T10971 220-232 RB denotes Nevertheless
T10972 253-258 VBN denotes noted
T10973 232-234 , denotes ,
T10974 234-236 PRP denotes we
T10975 237-241 VBP denotes have
T10976 242-252 RB denotes previously
T10977 259-263 IN denotes that
T10978 317-320 VBP denotes are
T10979 264-268 NN denotes none
T10980 269-271 IN denotes of
T10981 272-275 DT denotes the
T10982 284-293 NNS denotes mutations
T10983 276-283 JJ denotes natural
T10984 294-301 VBG denotes causing
T10985 302-305 NN denotes ATR
T10986 306-307 NN denotes X
T10987 305-306 HYPH denotes -
T10988 308-316 NN denotes syndrome
T10989 321-326 NNS denotes nulls
T10990 326-328 , denotes ,
T10991 328-333 WDT denotes which
T10992 334-342 VBZ denotes suggests
T10993 343-347 IN denotes that
T10994 351-356 VBZ denotes plays
T10995 348-350 PRP denotes it
T10996 357-358 DT denotes a
T10997 368-372 NN denotes role
T10998 359-367 JJ denotes critical
T10999 373-375 IN denotes in
T11000 376-382 JJ denotes normal
T11001 383-394 NN denotes development
T11002 394-395 . denotes .
T11003 395-597 sentence denotes Results of conditional inactivation of Atrx in the developing mouse forebrain, based on the Atrx flox allele described here, shows that Atrx exerts a major effect on terminally differentiating neurons.
T11004 396-403 NNS denotes Results
T11005 521-526 VBZ denotes shows
T11006 404-406 IN denotes of
T11007 407-418 JJ denotes conditional
T11008 419-431 NN denotes inactivation
T11009 432-434 IN denotes of
T11010 435-439 NN denotes Atrx
T11011 440-442 IN denotes in
T11012 443-446 DT denotes the
T11013 464-473 NN denotes forebrain
T11014 447-457 VBG denotes developing
T11015 458-463 NN denotes mouse
T11016 473-475 , denotes ,
T11017 475-480 VBN denotes based
T11018 481-483 IN denotes on
T11019 484-487 DT denotes the
T11020 498-504 NN denotes allele
T11021 488-497 NN denotes Atrx flox
T11022 505-514 VBN denotes described
T11023 515-519 RB denotes here
T11024 519-521 , denotes ,
T11025 527-531 IN denotes that
T11026 537-543 VBZ denotes exerts
T11027 532-536 NN denotes Atrx
T11028 544-545 DT denotes a
T11029 552-558 NN denotes effect
T11030 546-551 JJ denotes major
T11031 559-561 IN denotes on
T11032 562-572 RB denotes terminally
T11033 573-588 VBG denotes differentiating
T11034 589-596 NNS denotes neurons
T11035 596-597 . denotes .
T11036 597-660 sentence denotes Conditional inactivation of Atrx in other tissues is underway.
T11037 598-609 JJ denotes Conditional
T11038 610-622 NN denotes inactivation
T11039 648-650 VBZ denotes is
T11040 623-625 IN denotes of
T11041 626-630 NN denotes Atrx
T11042 631-633 IN denotes in
T11043 634-639 JJ denotes other
T11044 640-647 NNS denotes tissues
T11045 651-659 JJ denotes underway
T11046 659-660 . denotes .
T11047 660-849 sentence denotes Here we have shown that animal-wide disruption of the Atrx gene causes a severe embryonic-lethal phenotype, revealing an essential role for Atrx in the formation of the murine trophoblast.
T11048 661-665 RB denotes Here
T11049 674-679 VBN denotes shown
T11050 666-668 PRP denotes we
T11051 669-673 VBP denotes have
T11052 680-684 IN denotes that
T11053 725-731 VBZ denotes causes
T11054 685-691 NN denotes animal
T11055 692-696 JJ denotes wide
T11056 691-692 HYPH denotes -
T11057 697-707 NN denotes disruption
T11058 708-710 IN denotes of
T11059 711-714 DT denotes the
T11060 720-724 NN denotes gene
T11061 715-719 NN denotes Atrx
T11062 732-733 DT denotes a
T11063 758-767 NN denotes phenotype
T11064 734-740 JJ denotes severe
T11065 741-750 JJ denotes embryonic
T11066 751-757 JJ denotes lethal
T11067 750-751 HYPH denotes -
T11068 767-769 , denotes ,
T11069 769-778 VBG denotes revealing
T11070 779-781 DT denotes an
T11071 792-796 NN denotes role
T11072 782-791 JJ denotes essential
T11073 797-800 IN denotes for
T11074 801-805 NN denotes Atrx
T11075 806-808 IN denotes in
T11076 809-812 DT denotes the
T11077 813-822 NN denotes formation
T11078 823-825 IN denotes of
T11079 826-829 DT denotes the
T11080 837-848 NN denotes trophoblast
T11081 830-836 JJ denotes murine
T11082 848-849 . denotes .
T11083 849-980 sentence denotes In addition, Atrx appears to escape imprinted X-chromosome inactivation in the extraembryonic tissues of some carrier female mice.
T11084 850-852 IN denotes In
T11085 868-875 VBZ denotes appears
T11086 853-861 NN denotes addition
T11087 861-863 , denotes ,
T11088 863-867 NN denotes Atrx
T11089 876-878 TO denotes to
T11090 879-885 VB denotes escape
T11091 886-895 VBN denotes imprinted
T11092 898-908 NN denotes chromosome
T11093 896-897 NN denotes X
T11094 897-898 HYPH denotes -
T11095 909-921 NN denotes inactivation
T11096 922-924 IN denotes in
T11097 925-928 DT denotes the
T11098 944-951 NNS denotes tissues
T11099 929-943 JJ denotes extraembryonic
T11100 952-954 IN denotes of
T11101 955-959 DT denotes some
T11102 975-979 NNS denotes mice
T11103 960-967 NN denotes carrier
T11104 968-974 JJ denotes female
T11105 979-980 . denotes .
R6773 T10927 T10928 compound ATR,X
R6774 T10928 T10930 compound X,syndrome
R6775 T10929 T10928 punct -,X
R6776 T10930 T10931 nsubj syndrome,is
R6777 T10932 T10933 det the,disease
R6778 T10933 T10931 attr disease,is
R6779 T10934 T10933 amod first,disease
R6780 T10935 T10933 amod human,disease
R6781 T10936 T10933 amod genetic,disease
R6782 T10937 T10933 acl known,disease
R6783 T10938 T10939 aux to,caused
R6784 T10939 T10937 xcomp caused,known
R6785 T10940 T10939 auxpass be,caused
R6786 T10941 T10939 agent by,caused
R6787 T10942 T10941 pobj mutations,by
R6788 T10943 T10942 prep in,mutations
R6789 T10944 T10945 det a,factor
R6790 T10945 T10943 pobj factor,in
R6791 T10946 T10947 compound chromatin,remodelling
R6792 T10947 T10945 compound remodelling,factor
R6793 T10948 T10931 punct .,is
R6794 T10950 T10951 prep At,know
R6795 T10952 T10950 amod present,At
R6796 T10953 T10951 nsubj we,know
R6797 T10954 T10951 aux do,know
R6798 T10955 T10951 neg not,know
R6799 T10956 T10957 advmod how,influences
R6800 T10957 T10951 advcl influences,know
R6801 T10958 T10957 nsubj ATRX,influences
R6802 T10959 T10960 compound gene,expression
R6803 T10960 T10957 dobj expression,influences
R6804 T10961 T10957 cc or,influences
R6805 T10962 T10963 det what,effect
R6806 T10963 T10964 dep effect,has
R6807 T10964 T10957 conj has,influences
R6808 T10965 T10964 nsubj it,has
R6809 T10966 T10964 prep on,has
R6810 T10967 T10968 compound cell,behaviour
R6811 T10968 T10966 pobj behaviour,on
R6812 T10969 T10951 punct .,know
R6813 T10971 T10972 advmod Nevertheless,noted
R6814 T10973 T10972 punct ", ",noted
R6815 T10974 T10972 nsubj we,noted
R6816 T10975 T10972 aux have,noted
R6817 T10976 T10972 advmod previously,noted
R6818 T10977 T10978 mark that,are
R6819 T10978 T10972 ccomp are,noted
R6820 T10979 T10978 nsubj none,are
R6821 T10980 T10979 prep of,none
R6822 T10981 T10982 det the,mutations
R6823 T10982 T10980 pobj mutations,of
R6824 T10983 T10982 amod natural,mutations
R6825 T10984 T10982 acl causing,mutations
R6826 T10985 T10986 compound ATR,X
R6827 T10986 T10988 compound X,syndrome
R6828 T10987 T10986 punct -,X
R6829 T10988 T10984 dobj syndrome,causing
R6830 T10989 T10978 attr nulls,are
R6831 T10990 T10972 punct ", ",noted
R6832 T10991 T10992 dep which,suggests
R6833 T10992 T10972 advcl suggests,noted
R6834 T10993 T10994 mark that,plays
R6835 T10994 T10992 ccomp plays,suggests
R6836 T10995 T10994 nsubj it,plays
R6837 T10996 T10997 det a,role
R6838 T10997 T10994 dobj role,plays
R6839 T10998 T10997 amod critical,role
R6840 T10999 T10994 prep in,plays
R6841 T11000 T11001 amod normal,development
R6842 T11001 T10999 pobj development,in
R6843 T11002 T10972 punct .,noted
R6844 T11004 T11005 nsubj Results,shows
R6845 T11006 T11004 prep of,Results
R6846 T11007 T11008 amod conditional,inactivation
R6847 T11008 T11006 pobj inactivation,of
R6848 T11009 T11008 prep of,inactivation
R6849 T11010 T11009 pobj Atrx,of
R6850 T11011 T11008 prep in,inactivation
R6851 T11012 T11013 det the,forebrain
R6852 T11013 T11011 pobj forebrain,in
R6853 T11014 T11013 amod developing,forebrain
R6854 T11015 T11013 compound mouse,forebrain
R6855 T11016 T11004 punct ", ",Results
R6856 T11017 T11004 prep based,Results
R6857 T11018 T11017 prep on,based
R6858 T11019 T11020 det the,allele
R6859 T11020 T11018 pobj allele,on
R6860 T11021 T11020 compound Atrx flox,allele
R6861 T11022 T11020 acl described,allele
R6862 T11023 T11022 advmod here,described
R6863 T11024 T11005 punct ", ",shows
R6864 T11025 T11026 mark that,exerts
R6865 T11026 T11005 ccomp exerts,shows
R6866 T11027 T11026 nsubj Atrx,exerts
R6867 T11028 T11029 det a,effect
R6868 T11029 T11026 dobj effect,exerts
R6869 T11030 T11029 amod major,effect
R6870 T11031 T11026 prep on,exerts
R6871 T11032 T11033 advmod terminally,differentiating
R6872 T11033 T11034 amod differentiating,neurons
R6873 T11034 T11031 pobj neurons,on
R6874 T11035 T11005 punct .,shows
R6875 T11037 T11038 amod Conditional,inactivation
R6876 T11038 T11039 nsubj inactivation,is
R6877 T11040 T11038 prep of,inactivation
R6878 T11041 T11040 pobj Atrx,of
R6879 T11042 T11038 prep in,inactivation
R6880 T11043 T11044 amod other,tissues
R6881 T11044 T11042 pobj tissues,in
R6882 T11045 T11039 acomp underway,is
R6883 T11046 T11039 punct .,is
R6884 T11048 T11049 advmod Here,shown
R6885 T11050 T11049 nsubj we,shown
R6886 T11051 T11049 aux have,shown
R6887 T11052 T11053 mark that,causes
R6888 T11053 T11049 ccomp causes,shown
R6889 T11054 T11055 npadvmod animal,wide
R6890 T11055 T11057 amod wide,disruption
R6891 T11056 T11055 punct -,wide
R6892 T11057 T11053 nsubj disruption,causes
R6893 T11058 T11057 prep of,disruption
R6894 T11059 T11060 det the,gene
R6895 T11060 T11058 pobj gene,of
R6896 T11061 T11060 compound Atrx,gene
R6897 T11062 T11063 det a,phenotype
R6898 T11063 T11053 dobj phenotype,causes
R6899 T11064 T11063 amod severe,phenotype
R6900 T11065 T11066 amod embryonic,lethal
R6901 T11066 T11063 amod lethal,phenotype
R6902 T11067 T11066 punct -,lethal
R6903 T11068 T11049 punct ", ",shown
R6904 T11069 T11049 advcl revealing,shown
R6905 T11070 T11071 det an,role
R6906 T11071 T11069 dobj role,revealing
R6907 T11072 T11071 amod essential,role
R6908 T11073 T11071 prep for,role
R6909 T11074 T11073 pobj Atrx,for
R6910 T11075 T11071 prep in,role
R6911 T11076 T11077 det the,formation
R6912 T11077 T11075 pobj formation,in
R6913 T11078 T11077 prep of,formation
R6914 T11079 T11080 det the,trophoblast
R6915 T11080 T11078 pobj trophoblast,of
R6916 T11081 T11080 amod murine,trophoblast
R6917 T11082 T11049 punct .,shown
R6918 T11084 T11085 prep In,appears
R6919 T11086 T11084 pobj addition,In
R6920 T11087 T11085 punct ", ",appears
R6921 T11088 T11085 nsubj Atrx,appears
R6922 T11089 T11090 aux to,escape
R6923 T11090 T11085 xcomp escape,appears
R6924 T11091 T11092 amod imprinted,chromosome
R6925 T11092 T11095 compound chromosome,inactivation
R6926 T11093 T11092 compound X,chromosome
R6927 T11094 T11092 punct -,chromosome
R6928 T11095 T11090 dobj inactivation,escape
R6929 T11096 T11090 prep in,escape
R6930 T11097 T11098 det the,tissues
R6931 T11098 T11096 pobj tissues,in
R6932 T11099 T11098 amod extraembryonic,tissues
R6933 T11100 T11098 prep of,tissues
R6934 T11101 T11102 det some,mice
R6935 T11102 T11100 pobj mice,of
R6936 T11103 T11102 nmod carrier,mice
R6937 T11104 T11103 amod female,carrier
R6938 T11105 T11085 punct .,appears

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10885 4-5 GO:0000805 denotes X
T10886 28-33 NCBITaxon:9606 denotes human
T10887 34-41 SO_EXT:0000704 denotes genetic
T10888 72-81 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T10889 87-96 GO:0000785 denotes chromatin
T10890 87-108 GO:0006338 denotes chromatin remodelling
T10891 147-151 PR_EXT:000004503 denotes ATRX
T10892 163-167 SO_EXT:0000704 denotes gene
T10893 163-178 GO:0010467 denotes gene expression
T10894 204-208 CL_GO_EXT:cell denotes cell
T10895 209-218 GO_PATO_EXT:biological_behavior denotes behaviour
T10896 284-293 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T10897 306-307 GO:0000805 denotes X
T10898 321-326 SO_EXT:null_sequence_entity denotes nulls
T10899 435-439 PR_EXT:000004503 denotes Atrx
T10900 458-463 NCBITaxon:10088 denotes mouse
T10901 464-473 UBERON:0001890 denotes forebrain
T10902 488-492 PR_EXT:000004503 denotes Atrx
T10903 493-497 SO:0000359 denotes flox
T10904 498-504 SO_EXT:0001023 denotes allele
T10905 532-536 PR_EXT:000004503 denotes Atrx
T10906 573-588 GO_RO_EXT:developmental_differentiation_process denotes differentiating
T10907 589-596 CL:0000540 denotes neurons
T10908 626-630 PR_EXT:000004503 denotes Atrx
T10909 640-647 UBERON:0000479 denotes tissues
T10910 685-691 NCBITaxon:33208 denotes animal
T10911 715-719 PR_EXT:000004503 denotes Atrx
T10912 720-724 SO_EXT:0000704 denotes gene
T10913 741-750 UBERON:0000922 denotes embryonic
T10914 751-757 GO_EXT:fatality_or_lethality denotes lethal
T10915 801-805 PR_EXT:000004503 denotes Atrx
T10916 830-836 NCBITaxon:39107 denotes murine
T10917 837-848 UBERON:0000088 denotes trophoblast
T10918 863-867 PR_EXT:000004503 denotes Atrx
T10919 886-921 GO:0060819 denotes imprinted X-chromosome inactivation
T10920 896-908 GO:0000805 denotes X-chromosome
T10921 898-908 GO_SO_EXT:chromosome denotes chromosome
T10922 929-951 UBERON:0005292 denotes extraembryonic tissues
T10923 968-974 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T10924 975-979 NCBITaxon:10088 denotes mice

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10873 685-691 NCBITaxon:33208 denotes animal
T10874 715-719 PR:000004503 denotes Atrx
T10875 720-724 SO:0000704 denotes gene
T10876 741-750 UBERON:0000922 denotes embryonic
T10877 801-805 PR:000004503 denotes Atrx
T10878 830-836 NCBITaxon:39107 denotes murine
T10879 837-848 UBERON:0000088 denotes trophoblast
T10880 863-867 PR:000004503 denotes Atrx
T10881 886-921 GO:0060819 denotes imprinted X-chromosome inactivation
T10882 896-908 GO:0000805 denotes X-chromosome
T10883 929-951 UBERON:0005292 denotes extraembryonic tissues
T10884 975-979 NCBITaxon:10088 denotes mice
T10854 4-5 GO:0000805 denotes X
T10855 28-33 NCBITaxon:9606 denotes human
T10856 34-41 SO:0000704 denotes genetic
T10857 87-96 GO:0000785 denotes chromatin
T10858 87-108 GO:0006338 denotes chromatin remodelling
T10859 147-151 PR:000004503 denotes ATRX
T10860 163-167 SO:0000704 denotes gene
T10861 163-178 GO:0010467 denotes gene expression
T10862 306-307 GO:0000805 denotes X
T10863 435-439 PR:000004503 denotes Atrx
T10864 458-463 NCBITaxon:10088 denotes mouse
T10865 464-473 UBERON:0001890 denotes forebrain
T10866 488-492 PR:000004503 denotes Atrx
T10867 493-497 SO:0000359 denotes flox
T10868 498-504 SO:0001023 denotes allele
T10869 532-536 PR:000004503 denotes Atrx
T10870 589-596 CL:0000540 denotes neurons
T10871 626-630 PR:000004503 denotes Atrx
T10872 640-647 UBERON:0000479 denotes tissues