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PMC:1440874 / 49072-50060 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T10925 0-7 NN denotes Summary
T10926 7-124 sentence denotes ATR-X syndrome is the first human genetic disease known to be caused by mutations in a chromatin remodelling factor.
T10927 8-11 NN denotes ATR
T10928 12-13 NN denotes X
T10929 11-12 HYPH denotes -
T10930 14-22 NN denotes syndrome
T10931 23-25 VBZ denotes is
T10932 26-29 DT denotes the
T10933 50-57 NN denotes disease
T10934 30-35 JJ denotes first
T10935 36-41 JJ denotes human
T10936 42-49 JJ denotes genetic
T10937 58-63 VBN denotes known
T10938 64-66 TO denotes to
T10939 70-76 VBN denotes caused
T10940 67-69 VB denotes be
T10941 77-79 IN denotes by
T10942 80-89 NNS denotes mutations
T10943 90-92 IN denotes in
T10944 93-94 DT denotes a
T10945 117-123 NN denotes factor
T10946 95-104 NN denotes chromatin
T10947 105-116 NN denotes remodelling
T10948 123-124 . denotes .
T10949 124-227 sentence denotes At present we do not know how ATRX influences gene expression or what effect it has on cell behaviour.
T10950 125-127 IN denotes At
T10951 146-150 VB denotes know
T10952 128-135 JJ denotes present
T10953 136-138 PRP denotes we
T10954 139-141 VBP denotes do
T10955 142-145 RB denotes not
T10956 151-154 WRB denotes how
T10957 160-170 VBZ denotes influences
T10958 155-159 NN denotes ATRX
T10959 171-175 NN denotes gene
T10960 176-186 NN denotes expression
T10961 187-189 CC denotes or
T10962 190-194 WDT denotes what
T10963 195-201 NN denotes effect
T10964 205-208 VBZ denotes has
T10965 202-204 PRP denotes it
T10966 209-211 IN denotes on
T10967 212-216 NN denotes cell
T10968 217-226 NN denotes behaviour
T10969 226-227 . denotes .
T10970 227-403 sentence denotes Nevertheless, we have previously noted that none of the natural mutations causing ATR-X syndrome are nulls, which suggests that it plays a critical role in normal development.
T10971 228-240 RB denotes Nevertheless
T10972 261-266 VBN denotes noted
T10973 240-242 , denotes ,
T10974 242-244 PRP denotes we
T10975 245-249 VBP denotes have
T10976 250-260 RB denotes previously
T10977 267-271 IN denotes that
T10978 325-328 VBP denotes are
T10979 272-276 NN denotes none
T10980 277-279 IN denotes of
T10981 280-283 DT denotes the
T10982 292-301 NNS denotes mutations
T10983 284-291 JJ denotes natural
T10984 302-309 VBG denotes causing
T10985 310-313 NN denotes ATR
T10986 314-315 NN denotes X
T10987 313-314 HYPH denotes -
T10988 316-324 NN denotes syndrome
T10989 329-334 NNS denotes nulls
T10990 334-336 , denotes ,
T10991 336-341 WDT denotes which
T10992 342-350 VBZ denotes suggests
T10993 351-355 IN denotes that
T10994 359-364 VBZ denotes plays
T10995 356-358 PRP denotes it
T10996 365-366 DT denotes a
T10997 376-380 NN denotes role
T10998 367-375 JJ denotes critical
T10999 381-383 IN denotes in
T11000 384-390 JJ denotes normal
T11001 391-402 NN denotes development
T11002 402-403 . denotes .
T11003 403-605 sentence denotes Results of conditional inactivation of Atrx in the developing mouse forebrain, based on the Atrx flox allele described here, shows that Atrx exerts a major effect on terminally differentiating neurons.
T11004 404-411 NNS denotes Results
T11005 529-534 VBZ denotes shows
T11006 412-414 IN denotes of
T11007 415-426 JJ denotes conditional
T11008 427-439 NN denotes inactivation
T11009 440-442 IN denotes of
T11010 443-447 NN denotes Atrx
T11011 448-450 IN denotes in
T11012 451-454 DT denotes the
T11013 472-481 NN denotes forebrain
T11014 455-465 VBG denotes developing
T11015 466-471 NN denotes mouse
T11016 481-483 , denotes ,
T11017 483-488 VBN denotes based
T11018 489-491 IN denotes on
T11019 492-495 DT denotes the
T11020 506-512 NN denotes allele
T11021 496-505 NN denotes Atrx flox
T11022 513-522 VBN denotes described
T11023 523-527 RB denotes here
T11024 527-529 , denotes ,
T11025 535-539 IN denotes that
T11026 545-551 VBZ denotes exerts
T11027 540-544 NN denotes Atrx
T11028 552-553 DT denotes a
T11029 560-566 NN denotes effect
T11030 554-559 JJ denotes major
T11031 567-569 IN denotes on
T11032 570-580 RB denotes terminally
T11033 581-596 VBG denotes differentiating
T11034 597-604 NNS denotes neurons
T11035 604-605 . denotes .
T11036 605-668 sentence denotes Conditional inactivation of Atrx in other tissues is underway.
T11037 606-617 JJ denotes Conditional
T11038 618-630 NN denotes inactivation
T11039 656-658 VBZ denotes is
T11040 631-633 IN denotes of
T11041 634-638 NN denotes Atrx
T11042 639-641 IN denotes in
T11043 642-647 JJ denotes other
T11044 648-655 NNS denotes tissues
T11045 659-667 JJ denotes underway
T11046 667-668 . denotes .
T11047 668-857 sentence denotes Here we have shown that animal-wide disruption of the Atrx gene causes a severe embryonic-lethal phenotype, revealing an essential role for Atrx in the formation of the murine trophoblast.
T11048 669-673 RB denotes Here
T11049 682-687 VBN denotes shown
T11050 674-676 PRP denotes we
T11051 677-681 VBP denotes have
T11052 688-692 IN denotes that
T11053 733-739 VBZ denotes causes
T11054 693-699 NN denotes animal
T11055 700-704 JJ denotes wide
T11056 699-700 HYPH denotes -
T11057 705-715 NN denotes disruption
T11058 716-718 IN denotes of
T11059 719-722 DT denotes the
T11060 728-732 NN denotes gene
T11061 723-727 NN denotes Atrx
T11062 740-741 DT denotes a
T11063 766-775 NN denotes phenotype
T11064 742-748 JJ denotes severe
T11065 749-758 JJ denotes embryonic
T11066 759-765 JJ denotes lethal
T11067 758-759 HYPH denotes -
T11068 775-777 , denotes ,
T11069 777-786 VBG denotes revealing
T11070 787-789 DT denotes an
T11071 800-804 NN denotes role
T11072 790-799 JJ denotes essential
T11073 805-808 IN denotes for
T11074 809-813 NN denotes Atrx
T11075 814-816 IN denotes in
T11076 817-820 DT denotes the
T11077 821-830 NN denotes formation
T11078 831-833 IN denotes of
T11079 834-837 DT denotes the
T11080 845-856 NN denotes trophoblast
T11081 838-844 JJ denotes murine
T11082 856-857 . denotes .
T11083 857-988 sentence denotes In addition, Atrx appears to escape imprinted X-chromosome inactivation in the extraembryonic tissues of some carrier female mice.
T11084 858-860 IN denotes In
T11085 876-883 VBZ denotes appears
T11086 861-869 NN denotes addition
T11087 869-871 , denotes ,
T11088 871-875 NN denotes Atrx
T11089 884-886 TO denotes to
T11090 887-893 VB denotes escape
T11091 894-903 VBN denotes imprinted
T11092 906-916 NN denotes chromosome
T11093 904-905 NN denotes X
T11094 905-906 HYPH denotes -
T11095 917-929 NN denotes inactivation
T11096 930-932 IN denotes in
T11097 933-936 DT denotes the
T11098 952-959 NNS denotes tissues
T11099 937-951 JJ denotes extraembryonic
T11100 960-962 IN denotes of
T11101 963-967 DT denotes some
T11102 983-987 NNS denotes mice
T11103 968-975 NN denotes carrier
T11104 976-982 JJ denotes female
T11105 987-988 . denotes .
R6773 T10927 T10928 compound ATR,X
R6774 T10928 T10930 compound X,syndrome
R6775 T10929 T10928 punct -,X
R6776 T10930 T10931 nsubj syndrome,is
R6777 T10932 T10933 det the,disease
R6778 T10933 T10931 attr disease,is
R6779 T10934 T10933 amod first,disease
R6780 T10935 T10933 amod human,disease
R6781 T10936 T10933 amod genetic,disease
R6782 T10937 T10933 acl known,disease
R6783 T10938 T10939 aux to,caused
R6784 T10939 T10937 xcomp caused,known
R6785 T10940 T10939 auxpass be,caused
R6786 T10941 T10939 agent by,caused
R6787 T10942 T10941 pobj mutations,by
R6788 T10943 T10942 prep in,mutations
R6789 T10944 T10945 det a,factor
R6790 T10945 T10943 pobj factor,in
R6791 T10946 T10947 compound chromatin,remodelling
R6792 T10947 T10945 compound remodelling,factor
R6793 T10948 T10931 punct .,is
R6794 T10950 T10951 prep At,know
R6795 T10952 T10950 amod present,At
R6796 T10953 T10951 nsubj we,know
R6797 T10954 T10951 aux do,know
R6798 T10955 T10951 neg not,know
R6799 T10956 T10957 advmod how,influences
R6800 T10957 T10951 advcl influences,know
R6801 T10958 T10957 nsubj ATRX,influences
R6802 T10959 T10960 compound gene,expression
R6803 T10960 T10957 dobj expression,influences
R6804 T10961 T10957 cc or,influences
R6805 T10962 T10963 det what,effect
R6806 T10963 T10964 dep effect,has
R6807 T10964 T10957 conj has,influences
R6808 T10965 T10964 nsubj it,has
R6809 T10966 T10964 prep on,has
R6810 T10967 T10968 compound cell,behaviour
R6811 T10968 T10966 pobj behaviour,on
R6812 T10969 T10951 punct .,know
R6813 T10971 T10972 advmod Nevertheless,noted
R6814 T10973 T10972 punct ", ",noted
R6815 T10974 T10972 nsubj we,noted
R6816 T10975 T10972 aux have,noted
R6817 T10976 T10972 advmod previously,noted
R6818 T10977 T10978 mark that,are
R6819 T10978 T10972 ccomp are,noted
R6820 T10979 T10978 nsubj none,are
R6821 T10980 T10979 prep of,none
R6822 T10981 T10982 det the,mutations
R6823 T10982 T10980 pobj mutations,of
R6824 T10983 T10982 amod natural,mutations
R6825 T10984 T10982 acl causing,mutations
R6826 T10985 T10986 compound ATR,X
R6827 T10986 T10988 compound X,syndrome
R6828 T10987 T10986 punct -,X
R6829 T10988 T10984 dobj syndrome,causing
R6830 T10989 T10978 attr nulls,are
R6831 T10990 T10972 punct ", ",noted
R6832 T10991 T10992 dep which,suggests
R6833 T10992 T10972 advcl suggests,noted
R6834 T10993 T10994 mark that,plays
R6835 T10994 T10992 ccomp plays,suggests
R6836 T10995 T10994 nsubj it,plays
R6837 T10996 T10997 det a,role
R6838 T10997 T10994 dobj role,plays
R6839 T10998 T10997 amod critical,role
R6840 T10999 T10994 prep in,plays
R6841 T11000 T11001 amod normal,development
R6842 T11001 T10999 pobj development,in
R6843 T11002 T10972 punct .,noted
R6844 T11004 T11005 nsubj Results,shows
R6845 T11006 T11004 prep of,Results
R6846 T11007 T11008 amod conditional,inactivation
R6847 T11008 T11006 pobj inactivation,of
R6848 T11009 T11008 prep of,inactivation
R6849 T11010 T11009 pobj Atrx,of
R6850 T11011 T11008 prep in,inactivation
R6851 T11012 T11013 det the,forebrain
R6852 T11013 T11011 pobj forebrain,in
R6853 T11014 T11013 amod developing,forebrain
R6854 T11015 T11013 compound mouse,forebrain
R6855 T11016 T11004 punct ", ",Results
R6856 T11017 T11004 prep based,Results
R6857 T11018 T11017 prep on,based
R6858 T11019 T11020 det the,allele
R6859 T11020 T11018 pobj allele,on
R6860 T11021 T11020 compound Atrx flox,allele
R6861 T11022 T11020 acl described,allele
R6862 T11023 T11022 advmod here,described
R6863 T11024 T11005 punct ", ",shows
R6864 T11025 T11026 mark that,exerts
R6865 T11026 T11005 ccomp exerts,shows
R6866 T11027 T11026 nsubj Atrx,exerts
R6867 T11028 T11029 det a,effect
R6868 T11029 T11026 dobj effect,exerts
R6869 T11030 T11029 amod major,effect
R6870 T11031 T11026 prep on,exerts
R6871 T11032 T11033 advmod terminally,differentiating
R6872 T11033 T11034 amod differentiating,neurons
R6873 T11034 T11031 pobj neurons,on
R6874 T11035 T11005 punct .,shows
R6875 T11037 T11038 amod Conditional,inactivation
R6876 T11038 T11039 nsubj inactivation,is
R6877 T11040 T11038 prep of,inactivation
R6878 T11041 T11040 pobj Atrx,of
R6879 T11042 T11038 prep in,inactivation
R6880 T11043 T11044 amod other,tissues
R6881 T11044 T11042 pobj tissues,in
R6882 T11045 T11039 acomp underway,is
R6883 T11046 T11039 punct .,is
R6884 T11048 T11049 advmod Here,shown
R6885 T11050 T11049 nsubj we,shown
R6886 T11051 T11049 aux have,shown
R6887 T11052 T11053 mark that,causes
R6888 T11053 T11049 ccomp causes,shown
R6889 T11054 T11055 npadvmod animal,wide
R6890 T11055 T11057 amod wide,disruption
R6891 T11056 T11055 punct -,wide
R6892 T11057 T11053 nsubj disruption,causes
R6893 T11058 T11057 prep of,disruption
R6894 T11059 T11060 det the,gene
R6895 T11060 T11058 pobj gene,of
R6896 T11061 T11060 compound Atrx,gene
R6897 T11062 T11063 det a,phenotype
R6898 T11063 T11053 dobj phenotype,causes
R6899 T11064 T11063 amod severe,phenotype
R6900 T11065 T11066 amod embryonic,lethal
R6901 T11066 T11063 amod lethal,phenotype
R6902 T11067 T11066 punct -,lethal
R6903 T11068 T11049 punct ", ",shown
R6904 T11069 T11049 advcl revealing,shown
R6905 T11070 T11071 det an,role
R6906 T11071 T11069 dobj role,revealing
R6907 T11072 T11071 amod essential,role
R6908 T11073 T11071 prep for,role
R6909 T11074 T11073 pobj Atrx,for
R6910 T11075 T11071 prep in,role
R6911 T11076 T11077 det the,formation
R6912 T11077 T11075 pobj formation,in
R6913 T11078 T11077 prep of,formation
R6914 T11079 T11080 det the,trophoblast
R6915 T11080 T11078 pobj trophoblast,of
R6916 T11081 T11080 amod murine,trophoblast
R6917 T11082 T11049 punct .,shown
R6918 T11084 T11085 prep In,appears
R6919 T11086 T11084 pobj addition,In
R6920 T11087 T11085 punct ", ",appears
R6921 T11088 T11085 nsubj Atrx,appears
R6922 T11089 T11090 aux to,escape
R6923 T11090 T11085 xcomp escape,appears
R6924 T11091 T11092 amod imprinted,chromosome
R6925 T11092 T11095 compound chromosome,inactivation
R6926 T11093 T11092 compound X,chromosome
R6927 T11094 T11092 punct -,chromosome
R6928 T11095 T11090 dobj inactivation,escape
R6929 T11096 T11090 prep in,escape
R6930 T11097 T11098 det the,tissues
R6931 T11098 T11096 pobj tissues,in
R6932 T11099 T11098 amod extraembryonic,tissues
R6933 T11100 T11098 prep of,tissues
R6934 T11101 T11102 det some,mice
R6935 T11102 T11100 pobj mice,of
R6936 T11103 T11102 nmod carrier,mice
R6937 T11104 T11103 amod female,carrier
R6938 T11105 T11085 punct .,appears

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10885 12-13 GO:0000805 denotes X
T10886 36-41 NCBITaxon:9606 denotes human
T10887 42-49 SO_EXT:0000704 denotes genetic
T10888 80-89 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T10889 95-104 GO:0000785 denotes chromatin
T10890 95-116 GO:0006338 denotes chromatin remodelling
T10891 155-159 PR_EXT:000004503 denotes ATRX
T10892 171-175 SO_EXT:0000704 denotes gene
T10893 171-186 GO:0010467 denotes gene expression
T10894 212-216 CL_GO_EXT:cell denotes cell
T10895 217-226 GO_PATO_EXT:biological_behavior denotes behaviour
T10896 292-301 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T10897 314-315 GO:0000805 denotes X
T10898 329-334 SO_EXT:null_sequence_entity denotes nulls
T10899 443-447 PR_EXT:000004503 denotes Atrx
T10900 466-471 NCBITaxon:10088 denotes mouse
T10901 472-481 UBERON:0001890 denotes forebrain
T10902 496-500 PR_EXT:000004503 denotes Atrx
T10903 501-505 SO:0000359 denotes flox
T10904 506-512 SO_EXT:0001023 denotes allele
T10905 540-544 PR_EXT:000004503 denotes Atrx
T10906 581-596 GO_RO_EXT:developmental_differentiation_process denotes differentiating
T10907 597-604 CL:0000540 denotes neurons
T10908 634-638 PR_EXT:000004503 denotes Atrx
T10909 648-655 UBERON:0000479 denotes tissues
T10910 693-699 NCBITaxon:33208 denotes animal
T10911 723-727 PR_EXT:000004503 denotes Atrx
T10912 728-732 SO_EXT:0000704 denotes gene
T10913 749-758 UBERON:0000922 denotes embryonic
T10914 759-765 GO_EXT:fatality_or_lethality denotes lethal
T10915 809-813 PR_EXT:000004503 denotes Atrx
T10916 838-844 NCBITaxon:39107 denotes murine
T10917 845-856 UBERON:0000088 denotes trophoblast
T10918 871-875 PR_EXT:000004503 denotes Atrx
T10919 894-929 GO:0060819 denotes imprinted X-chromosome inactivation
T10920 904-916 GO:0000805 denotes X-chromosome
T10921 906-916 GO_SO_EXT:chromosome denotes chromosome
T10922 937-959 UBERON:0005292 denotes extraembryonic tissues
T10923 976-982 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T10924 983-987 NCBITaxon:10088 denotes mice

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10873 693-699 NCBITaxon:33208 denotes animal
T10874 723-727 PR:000004503 denotes Atrx
T10875 728-732 SO:0000704 denotes gene
T10876 749-758 UBERON:0000922 denotes embryonic
T10877 809-813 PR:000004503 denotes Atrx
T10878 838-844 NCBITaxon:39107 denotes murine
T10879 845-856 UBERON:0000088 denotes trophoblast
T10880 871-875 PR:000004503 denotes Atrx
T10881 894-929 GO:0060819 denotes imprinted X-chromosome inactivation
T10882 904-916 GO:0000805 denotes X-chromosome
T10883 937-959 UBERON:0005292 denotes extraembryonic tissues
T10884 983-987 NCBITaxon:10088 denotes mice
T10854 12-13 GO:0000805 denotes X
T10855 36-41 NCBITaxon:9606 denotes human
T10856 42-49 SO:0000704 denotes genetic
T10857 95-104 GO:0000785 denotes chromatin
T10858 95-116 GO:0006338 denotes chromatin remodelling
T10859 155-159 PR:000004503 denotes ATRX
T10860 171-175 SO:0000704 denotes gene
T10861 171-186 GO:0010467 denotes gene expression
T10862 314-315 GO:0000805 denotes X
T10863 443-447 PR:000004503 denotes Atrx
T10864 466-471 NCBITaxon:10088 denotes mouse
T10865 472-481 UBERON:0001890 denotes forebrain
T10866 496-500 PR:000004503 denotes Atrx
T10867 501-505 SO:0000359 denotes flox
T10868 506-512 SO:0001023 denotes allele
T10869 540-544 PR:000004503 denotes Atrx
T10870 597-604 CL:0000540 denotes neurons
T10871 634-638 PR:000004503 denotes Atrx
T10872 648-655 UBERON:0000479 denotes tissues