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surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18]. Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele. Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce. Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T9734","span":{"begin":61,"end":67},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T9735","span":{"begin":68,"end":75},"obj":"UBERON:0000922"},{"id":"T9736","span":{"begin":100,"end":104},"obj":"PR_EXT:000004503"},{"id":"T9737","span":{"begin":105,"end":107},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T9738","span":{"begin":108,"end":114},"obj":"SO_EXT:0001023"},{"id":"T9739","span":{"begin":148,"end":172},"obj":"GO:0060819"},{"id":"T9740","span":{"begin":158,"end":159},"obj":"GO:0000805"},{"id":"T9741","span":{"begin":191,"end":199},"obj":"GO:0016458"},{"id":"T9742","span":{"begin":207,"end":217},"obj":"GO_SO_EXT:chromosome"},{"id":"T9743","span":{"begin":230,"end":239},"obj":"UBERON:0000922"},{"id":"T9744","span":{"begin":255,"end":261},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T9745","span":{"begin":262,"end":268},"obj":"NCBITaxon:39107"},{"id":"T9746","span":{"begin":269,"end":276},"obj":"UBERON:0000479"},{"id":"T9747","span":{"begin":283,"end":292},"obj":"GO:0016458"},{"id":"T9748","span":{"begin":300,"end":304},"obj":"PR_EXT:000004503"},{"id":"T9749","span":{"begin":305,"end":307},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T9750","span":{"begin":308,"end":314},"obj":"SO_EXT:0001023"},{"id":"T9751","span":{"begin":341,"end":348},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T9752","span":{"begin":349,"end":353},"obj":"SO_EXT:sequence_nullness"},{"id":"T9753","span":{"begin":358,"end":362},"obj":"PR_EXT:000004503"},{"id":"T9754","span":{"begin":370,"end":392},"obj":"UBERON:0005292"},{"id":"T9755","span":{"begin":423,"end":433},"obj":"GO_SO_EXT:chromosome"},{"id":"T9756","span":{"begin":446,"end":450},"obj":"PR_EXT:000004503"},{"id":"T9757","span":{"begin":459,"end":465},"obj":"SO_EXT:0001023"},{"id":"T9758","span":{"begin":508,"end":512},"obj":"PR_EXT:000004503"},{"id":"T9759","span":{"begin":521,"end":528},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T9760","span":{"begin":562,"end":571},"obj":"GO:0000003"},{"id":"T9761","span":{"begin":604,"end":611},"obj":"GO:0016458"},{"id":"T9762","span":{"begin":635,"end":639},"obj":"PR_EXT:000007899"},{"id":"T9763","span":{"begin":640,"end":642},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T9764","span":{"begin":643,"end":649},"obj":"SO_EXT:0001023"},{"id":"T9765","span":{"begin":657,"end":679},"obj":"UBERON:0005292"},{"id":"T9766","span":{"begin":691,"end":698},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T9767","span":{"begin":743,"end":747},"obj":"PR_EXT:000007899"},{"id":"T9768","span":{"begin":747,"end":751},"obj":"SO_EXT:sequence_nullness"},{"id":"T9769","span":{"begin":752,"end":757},"obj":"PATO_UBERON_EXT:male_or_bearer_of_maleness"},{"id":"T9770","span":{"begin":763,"end":767},"obj":"PR_EXT:000004503"},{"id":"T9771","span":{"begin":768,"end":775},"obj":"CHEBI_PR_EXT:protein"},{"id":"T9772","span":{"begin":826,"end":837},"obj":"UBERON:0000088"},{"id":"T9773","span":{"begin":884,"end":889},"obj":"NCBITaxon:10088"}],"text":"Another surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18]. Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele. Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce. Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse."}

{"project":"2_test","denotations":[{"id":"16628246-1152998-85799773","span":{"begin":278,"end":280},"obj":"1152998"},{"id":"T3361","span":{"begin":278,"end":280},"obj":"1152998"}],"text":"Another surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18]. Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele. Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce. Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T9601","span":{"begin":68,"end":75},"obj":"UBERON:0000922"},{"id":"T9602","span":{"begin":100,"end":104},"obj":"PR:000004503"},{"id":"T9603","span":{"begin":108,"end":114},"obj":"SO:0001023"},{"id":"T9604","span":{"begin":148,"end":172},"obj":"GO:0060819"},{"id":"T9605","span":{"begin":158,"end":159},"obj":"GO:0000805"},{"id":"T9606","span":{"begin":191,"end":199},"obj":"GO:0016458"},{"id":"T9607","span":{"begin":230,"end":239},"obj":"UBERON:0000922"},{"id":"T9608","span":{"begin":262,"end":268},"obj":"NCBITaxon:39107"},{"id":"T9609","span":{"begin":269,"end":276},"obj":"UBERON:0000479"},{"id":"T9610","span":{"begin":283,"end":292},"obj":"GO:0016458"},{"id":"T9611","span":{"begin":300,"end":304},"obj":"PR:000004503"},{"id":"T9612","span":{"begin":308,"end":314},"obj":"SO:0001023"},{"id":"T9613","span":{"begin":358,"end":362},"obj":"PR:000004503"},{"id":"T9614","span":{"begin":370,"end":392},"obj":"UBERON:0005292"},{"id":"T9615","span":{"begin":446,"end":450},"obj":"PR:000004503"},{"id":"T9616","span":{"begin":459,"end":465},"obj":"SO:0001023"},{"id":"T9617","span":{"begin":508,"end":512},"obj":"PR:000004503"},{"id":"T9618","span":{"begin":562,"end":571},"obj":"GO:0000003"},{"id":"T9619","span":{"begin":604,"end":611},"obj":"GO:0016458"},{"id":"T9620","span":{"begin":635,"end":639},"obj":"PR:000007899"},{"id":"T9621","span":{"begin":643,"end":649},"obj":"SO:0001023"},{"id":"T9622","span":{"begin":657,"end":679},"obj":"UBERON:0005292"},{"id":"T9623","span":{"begin":743,"end":747},"obj":"PR:000007899"},{"id":"T9624","span":{"begin":763,"end":767},"obj":"PR:000004503"},{"id":"T9625","span":{"begin":826,"end":837},"obj":"UBERON:0000088"},{"id":"T9626","span":{"begin":884,"end":889},"obj":"NCBITaxon:10088"}],"text":"Another surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18]. Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele. Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce. Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse."}