> top > docs > PMC:1440874 > spans > 44132-49070 > annotations

PMC:1440874 / 44132-49070 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id Subject Object Predicate Lexical cue
T9932 0-4 NN denotes Atrx
T9933 5-12 VBZ denotes Escapes
T9934 13-22 VBN denotes Imprinted
T9935 25-37 NN denotes Inactivation
T9936 23-24 NN denotes X
T9937 24-25 HYPH denotes -
T9938 38-40 IN denotes in
T9939 41-55 JJ denotes Extraembryonic
T9940 56-63 NNS denotes Tissues
T9941 64-66 IN denotes of
T9942 67-74 NN denotes Carrier
T9943 82-86 NNS denotes Mice
T9944 75-81 JJ denotes Female
T9945 86-369 sentence denotes Another surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18].
T9946 87-94 DT denotes Another
T9947 106-113 NN denotes finding
T9948 95-105 JJ denotes surprising
T9949 128-130 VBZ denotes is
T9950 114-116 IN denotes of
T9951 117-121 DT denotes this
T9952 122-127 NN denotes study
T9953 131-135 IN denotes that
T9954 202-209 VBZ denotes appears
T9955 135-137 , denotes ,
T9956 137-139 IN denotes in
T9957 140-147 NN denotes carrier
T9958 155-162 NNS denotes embryos
T9959 148-154 JJ denotes female
T9960 162-164 , denotes ,
T9961 164-165 DT denotes a
T9962 195-201 NN denotes allele
T9963 166-176 RB denotes paternally
T9964 177-186 VBN denotes inherited
T9965 187-194 NN denotes Atrx WT
T9966 210-212 TO denotes to
T9967 213-219 VB denotes escape
T9968 220-223 DT denotes the
T9969 224-231 NN denotes process
T9970 232-234 IN denotes of
T9971 235-244 VBN denotes imprinted
T9972 247-259 NN denotes inactivation
T9973 245-246 NN denotes X
T9974 246-247 HYPH denotes -
T9975 259-261 , denotes ,
T9976 261-266 WDT denotes which
T9977 278-286 VBZ denotes silences
T9978 267-277 RB denotes ordinarily
T9979 287-290 DT denotes the
T9980 294-304 NN denotes chromosome
T9981 291-293 NN denotes Xp
T9982 305-307 IN denotes in
T9983 308-311 DT denotes the
T9984 327-338 NN denotes compartment
T9985 312-326 JJ denotes extraembryonic
T9986 339-341 IN denotes of
T9987 342-348 JJ denotes female
T9988 356-363 NNS denotes tissues
T9989 349-355 JJ denotes murine
T9990 364-365 -LRB- denotes [
T9991 365-367 CD denotes 18
T9992 367-368 -RRB- denotes ]
T9993 368-369 . denotes .
T9994 369-553 sentence denotes Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele.
T9995 370-379 NN denotes Silencing
T9996 415-421 VB denotes render
T9997 380-382 IN denotes of
T9998 383-386 DT denotes the
T9999 395-401 NN denotes allele
T10000 387-394 NN denotes Atrx WT
T10001 402-404 IN denotes on
T10002 405-407 NN denotes Xp
T10003 408-414 MD denotes should
T10004 422-427 DT denotes these
T10005 428-435 NNS denotes females
T10006 436-440 JJ denotes null
T10007 441-444 IN denotes for
T10008 445-449 NN denotes Atrx
T10009 450-452 IN denotes in
T10010 453-456 DT denotes the
T10011 472-479 NNS denotes tissues
T10012 457-471 JJ denotes extraembryonic
T10013 479-481 , denotes ,
T10014 481-486 IN denotes since
T10015 521-528 VBZ denotes carries
T10016 487-490 DT denotes the
T10017 510-520 NN denotes chromosome
T10018 491-499 RB denotes normally
T10019 500-506 JJ denotes active
T10020 507-509 NN denotes Xm
T10021 529-532 DT denotes the
T10022 546-552 NN denotes allele
T10023 533-545 NN denotes Atrx Δ18Δneo
T10024 552-553 . denotes .
T10025 553-659 sentence denotes Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce.
T10026 554-562 IN denotes Although
T10027 582-588 JJ denotes normal
T10028 563-566 RB denotes not
T10029 567-581 RB denotes phenotypically
T10030 616-625 VBD denotes developed
T10031 588-590 , denotes ,
T10032 590-594 DT denotes some
T10033 608-615 NNS denotes females
T10034 595-599 NN denotes Atrx
T10035 600-607 NN denotes carrier
T10036 626-628 IN denotes to
T10037 629-633 NN denotes term
T10038 634-637 CC denotes and
T10039 638-642 VBD denotes went
T10040 643-645 RP denotes on
T10041 646-648 TO denotes to
T10042 649-658 VB denotes reproduce
T10043 658-659 . denotes .
T10044 659-977 sentence denotes Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse.
T10045 660-664 RB denotes Thus
T10046 786-788 VBZ denotes is
T10047 664-666 , denotes ,
T10048 666-669 DT denotes the
T10049 670-677 NN denotes failure
T10050 678-680 TO denotes to
T10051 691-698 VB denotes silence
T10052 681-690 RB denotes correctly
T10053 699-702 DT denotes the
T10054 730-736 NN denotes allele
T10146 1230-1239 NN denotes phosphate
T10055 703-713 RB denotes paternally
T10056 714-721 VBN denotes derived
T10057 722-729 NN denotes Atrx WT
T10058 737-739 IN denotes in
T10059 740-743 DT denotes the
T10060 759-766 NNS denotes tissues
T10061 744-758 JJ denotes extraembryonic
T10062 767-769 IN denotes of
T10063 770-777 NN denotes carrier
T10064 778-785 NNS denotes females
T10065 789-799 JJ denotes consistent
T10066 800-804 IN denotes with
T10067 805-808 PRP$ denotes our
T10068 809-821 NNS denotes observations
T10069 822-826 IN denotes that
T10070 863-868 VBZ denotes plays
T10071 827-829 IN denotes in
T10072 830-838 JJ denotes Atrxnull
T10073 839-844 NNS denotes males
T10074 844-846 , denotes ,
T10075 846-849 DT denotes the
T10076 855-862 NN denotes protein
T10077 850-854 NN denotes Atrx
T10078 869-871 DT denotes an
T10079 882-886 NN denotes role
T10080 872-881 JJ denotes essential
T10081 887-889 IN denotes in
T10082 890-893 DT denotes the
T10083 894-905 NN denotes development
T10084 906-908 IN denotes of
T10085 909-912 DT denotes the
T10086 913-924 NN denotes trophoblast
T10087 925-928 CC denotes and
T10088 929-931 VBZ denotes is
T10089 932-941 JJ denotes necessary
T10090 942-945 IN denotes for
T10091 946-954 NN denotes survival
T10092 955-957 FW denotes in
T10093 958-963 FW denotes utero
T10094 964-966 IN denotes in
T10095 967-970 DT denotes the
T10096 971-976 NN denotes mouse
T10097 976-977 . denotes .
T10098 977-1162 sentence denotes The survival of Atrx carrier females contrasts with the phenotypes seen in carriers of mutations of other murine X-linked genes known to be essential in the extraembryonic compartment.
T10099 978-981 DT denotes The
T10100 982-990 NN denotes survival
T10101 1015-1024 VBZ denotes contrasts
T10102 991-993 IN denotes of
T10103 994-998 NN denotes Atrx
T10104 1007-1014 NNS denotes females
T10105 999-1006 NN denotes carrier
T10106 1025-1029 IN denotes with
T10107 1030-1033 DT denotes the
T10108 1034-1044 NNS denotes phenotypes
T10109 1045-1049 VBN denotes seen
T10110 1050-1052 IN denotes in
T10111 1053-1061 NNS denotes carriers
T10112 1062-1064 IN denotes of
T10113 1065-1074 NNS denotes mutations
T10114 1075-1077 IN denotes of
T10115 1078-1083 JJ denotes other
T10116 1100-1105 NNS denotes genes
T10117 1084-1090 JJ denotes murine
T10118 1091-1092 NN denotes X
T10119 1093-1099 VBN denotes linked
T10120 1092-1093 HYPH denotes -
T10121 1106-1111 VBN denotes known
T10122 1112-1114 TO denotes to
T10123 1115-1117 VB denotes be
T10124 1118-1127 JJ denotes essential
T10125 1128-1130 IN denotes in
T10126 1131-1134 DT denotes the
T10127 1150-1161 NN denotes compartment
T10128 1135-1149 JJ denotes extraembryonic
T10129 1161-1162 . denotes .
T10130 1162-1401 sentence denotes For example, targeted disruption of the dyskerin (Dkc1), glucose 6-phosphate dehydrogenase (G6PD), and choroideremia (Chm) genes cause embryonic lethality in null male embryos through defects of the extraembryonic-derived tissues [29–31].
T10131 1163-1166 IN denotes For
T10132 1292-1297 VBP denotes cause
T10133 1167-1174 NN denotes example
T10134 1174-1176 , denotes ,
T10135 1176-1184 VBN denotes targeted
T10136 1185-1195 NN denotes disruption
T10137 1196-1198 IN denotes of
T10138 1199-1202 DT denotes the
T10139 1286-1291 NNS denotes genes
T10140 1203-1211 NN denotes dyskerin
T10141 1212-1213 -LRB- denotes (
T10142 1213-1217 NN denotes Dkc1
T10143 1217-1218 -RRB- denotes )
T10144 1218-1220 , denotes ,
T10145 1220-1227 NN denotes glucose
T10147 1228-1229 CD denotes 6
T10148 1229-1230 HYPH denotes -
T10149 1240-1253 NN denotes dehydrogenase
T10150 1254-1255 -LRB- denotes (
T10151 1255-1259 NN denotes G6PD
T10152 1259-1260 -RRB- denotes )
T10153 1260-1262 , denotes ,
T10154 1262-1265 CC denotes and
T10155 1266-1279 NN denotes choroideremia
T10156 1280-1281 -LRB- denotes (
T10157 1281-1284 NN denotes Chm
T10158 1284-1285 -RRB- denotes )
T10159 1298-1307 JJ denotes embryonic
T10160 1308-1317 NN denotes lethality
T10161 1318-1320 IN denotes in
T10162 1321-1325 JJ denotes null
T10163 1331-1338 NNS denotes embryos
T10164 1326-1330 JJ denotes male
T10165 1339-1346 IN denotes through
T10166 1347-1354 NNS denotes defects
T10167 1355-1357 IN denotes of
T10168 1358-1361 DT denotes the
T10169 1385-1392 NNS denotes tissues
T10170 1362-1376 JJ denotes extraembryonic
T10171 1377-1384 VBN denotes derived
T10172 1376-1377 HYPH denotes -
T10173 1393-1394 -LRB- denotes [
T10174 1394-1396 CD denotes 29
T10175 1396-1397 SYM denotes
T10176 1397-1399 CD denotes 31
T10177 1399-1400 -RRB- denotes ]
T10178 1400-1401 . denotes .
T10179 1401-1579 sentence denotes Female mice carrying mutations of these genes on the maternally inherited X chromosome also die in utero, whereas females that inherit the mutation on the Xp chromosome survive.
T10180 1402-1408 JJ denotes Female
T10181 1409-1413 NNS denotes mice
T10182 1494-1497 VBP denotes die
T10183 1414-1422 VBG denotes carrying
T10184 1423-1432 NNS denotes mutations
T10185 1433-1435 IN denotes of
T10186 1436-1441 DT denotes these
T10187 1442-1447 NNS denotes genes
T10188 1448-1450 IN denotes on
T10189 1451-1454 DT denotes the
T10190 1478-1488 NN denotes chromosome
T10191 1455-1465 RB denotes maternally
T10192 1466-1475 VBN denotes inherited
T10193 1476-1477 NN denotes X
T10194 1489-1493 RB denotes also
T10195 1498-1500 FW denotes in
T10196 1501-1506 FW denotes utero
T10197 1506-1508 , denotes ,
T10198 1508-1515 IN denotes whereas
T10199 1571-1578 VBP denotes survive
T10200 1516-1523 NNS denotes females
T10201 1524-1528 WDT denotes that
T10202 1529-1536 VBP denotes inherit
T10203 1537-1540 DT denotes the
T10204 1541-1549 NN denotes mutation
T10205 1550-1552 IN denotes on
T10206 1553-1556 DT denotes the
T10207 1560-1570 NN denotes chromosome
T10208 1557-1559 NN denotes Xp
T10209 1578-1579 . denotes .
T10210 1579-1800 sentence denotes Thus, unlike Atrx, these genes and/or their effects on cell growth are unable to circumvent the processes that ultimately cause all cells in the extraembryonic tissues to express only the maternally derived X chromosome.
T10211 1580-1584 RB denotes Thus
T10212 1647-1650 VBP denotes are
T10213 1584-1586 , denotes ,
T10214 1586-1592 IN denotes unlike
T10215 1593-1597 NN denotes Atrx
T10216 1597-1599 , denotes ,
T10217 1599-1604 DT denotes these
T10218 1605-1610 NNS denotes genes
T10219 1611-1614 CC denotes and
T10220 1614-1615 HYPH denotes /
T10221 1615-1617 CC denotes or
T10222 1618-1623 PRP$ denotes their
T10223 1624-1631 NNS denotes effects
T10224 1632-1634 IN denotes on
T10225 1635-1639 NN denotes cell
T10226 1640-1646 NN denotes growth
T10227 1651-1657 JJ denotes unable
T10228 1658-1660 TO denotes to
T10229 1661-1671 VB denotes circumvent
T10230 1672-1675 DT denotes the
T10231 1676-1685 NNS denotes processes
T10232 1686-1690 WDT denotes that
T10233 1702-1707 VBP denotes cause
T10234 1691-1701 RB denotes ultimately
T10235 1708-1711 DT denotes all
T10236 1712-1717 NNS denotes cells
T10237 1751-1758 VB denotes express
T10238 1718-1720 IN denotes in
T10239 1721-1724 DT denotes the
T10240 1740-1747 NNS denotes tissues
T10241 1725-1739 JJ denotes extraembryonic
T10242 1748-1750 TO denotes to
T10243 1759-1763 RB denotes only
T10244 1789-1799 NN denotes chromosome
T10245 1764-1767 DT denotes the
T10246 1768-1778 RB denotes maternally
T10247 1779-1786 VBN denotes derived
T10248 1787-1788 NN denotes X
T10249 1799-1800 . denotes .
T10250 1800-1925 sentence denotes How might expression of the paternal Atrx WT allele be maintained in the extraembryonic tissues of the Atrx carrier females?
T10251 1801-1804 WRB denotes How
T10252 1856-1866 VBN denotes maintained
T10253 1805-1810 MD denotes might
T10254 1811-1821 NN denotes expression
T10255 1822-1824 IN denotes of
T10256 1825-1828 DT denotes the
T10257 1846-1852 NN denotes allele
T10258 1829-1837 JJ denotes paternal
T10259 1838-1845 NN denotes Atrx WT
T10260 1853-1855 VB denotes be
T10261 1867-1869 IN denotes in
T10262 1870-1873 DT denotes the
T10263 1889-1896 NNS denotes tissues
T10264 1874-1888 JJ denotes extraembryonic
T10265 1897-1899 IN denotes of
T10266 1900-1903 DT denotes the
T10267 1917-1924 NNS denotes females
T10268 1904-1908 NN denotes Atrx
T10269 1909-1916 NN denotes carrier
T10270 1924-1925 . denotes ?
T10271 1925-2159 sentence denotes One possibility is that, like some other X-linked genes, silencing of the Atrx gene on Xp is incomplete, such that there is always a low-level, leaky output of Atrx from a normally inactivated Xp chromosome in extraembryonic tissues.
T10272 1926-1929 CD denotes One
T10273 1930-1941 NN denotes possibility
T10274 1942-1944 VBZ denotes is
T10275 1945-1949 IN denotes that
T10276 2016-2018 VBZ denotes is
T10277 1949-1951 , denotes ,
T10278 1951-1955 IN denotes like
T10279 1956-1960 DT denotes some
T10280 1976-1981 NNS denotes genes
T10281 1961-1966 JJ denotes other
T10282 1967-1968 NN denotes X
T10283 1969-1975 JJ denotes linked
T10284 1968-1969 HYPH denotes -
T10285 1981-1983 , denotes ,
T10286 1983-1992 NN denotes silencing
T10287 1993-1995 IN denotes of
T10288 1996-1999 DT denotes the
T10289 2005-2009 NN denotes gene
T10290 2000-2004 NN denotes Atrx
T10291 2010-2012 IN denotes on
T10292 2013-2015 NN denotes Xp
T10293 2019-2029 JJ denotes incomplete
T10294 2029-2031 , denotes ,
T10295 2031-2035 JJ denotes such
T10296 2047-2049 VBZ denotes is
T10297 2036-2040 IN denotes that
T10298 2041-2046 EX denotes there
T10299 2050-2056 RB denotes always
T10300 2057-2058 DT denotes a
T10301 2076-2082 NN denotes output
T10302 2059-2062 JJ denotes low
T10303 2063-2068 NN denotes level
T10304 2062-2063 HYPH denotes -
T10305 2068-2070 , denotes ,
T10306 2070-2075 JJ denotes leaky
T10307 2083-2085 IN denotes of
T10308 2086-2090 NN denotes Atrx
T10309 2091-2095 IN denotes from
T10310 2096-2097 DT denotes a
T10311 2122-2132 NN denotes chromosome
T10312 2098-2106 RB denotes normally
T10313 2107-2118 VBN denotes inactivated
T10314 2119-2121 NN denotes Xp
T10315 2133-2135 IN denotes in
T10316 2136-2150 JJ denotes extraembryonic
T10317 2151-2158 NNS denotes tissues
T10318 2158-2159 . denotes .
T10319 2159-2437 sentence denotes However, it was recently demonstrated that the paternal Atrx (called Xnp) allele is completely silenced in a normal mouse trophoblast stem cell line [32], suggesting that Atrx does not normally escape imprinted X-inactivation in the extraembryonic tissues of wild-type females.
T10320 2160-2167 RB denotes However
T10321 2185-2197 VBN denotes demonstrated
T10322 2167-2169 , denotes ,
T10323 2169-2171 PRP denotes it
T10324 2172-2175 VBD denotes was
T10325 2176-2184 RB denotes recently
T10326 2198-2202 IN denotes that
T10327 2255-2263 VBN denotes silenced
T10328 2203-2206 DT denotes the
T10329 2234-2240 NN denotes allele
T10330 2207-2215 JJ denotes paternal
T10331 2216-2220 NN denotes Atrx
T10332 2221-2222 -LRB- denotes (
T10333 2222-2228 VBN denotes called
T10334 2229-2232 NN denotes Xnp
T10335 2232-2233 -RRB- denotes )
T10336 2241-2243 VBZ denotes is
T10337 2244-2254 RB denotes completely
T10338 2264-2266 IN denotes in
T10339 2267-2268 DT denotes a
T10340 2304-2308 NN denotes line
T10341 2269-2275 JJ denotes normal
T10342 2276-2281 NN denotes mouse
T10343 2282-2293 NN denotes trophoblast
T10344 2294-2298 NN denotes stem
T10345 2299-2303 NN denotes cell
T10346 2309-2310 -LRB- denotes [
T10347 2310-2312 CD denotes 32
T10348 2312-2313 -RRB- denotes ]
T10349 2313-2315 , denotes ,
T10350 2315-2325 VBG denotes suggesting
T10351 2326-2330 IN denotes that
T10352 2354-2360 VB denotes escape
T10353 2331-2335 NN denotes Atrx
T10354 2336-2340 VBZ denotes does
T10355 2341-2344 RB denotes not
T10356 2345-2353 RB denotes normally
T10357 2361-2370 VBN denotes imprinted
T10358 2373-2385 NN denotes inactivation
T10359 2371-2372 NN denotes X
T10360 2372-2373 HYPH denotes -
T10361 2386-2388 IN denotes in
T10362 2389-2392 DT denotes the
T10363 2408-2415 NNS denotes tissues
T10364 2393-2407 JJ denotes extraembryonic
T10365 2416-2418 IN denotes of
T10366 2419-2423 JJ denotes wild
T10367 2424-2428 NN denotes type
T10368 2423-2424 HYPH denotes -
T10369 2429-2436 NNS denotes females
T10370 2436-2437 . denotes .
T10371 2437-2561 sentence denotes Thus, the expression of the Xp-linked Atrx WT allele that we observed is unique to female carriers of the Atrx null allele.
T10372 2438-2442 RB denotes Thus
T10373 2508-2510 VBZ denotes is
T10374 2442-2444 , denotes ,
T10375 2444-2447 DT denotes the
T10376 2448-2458 NN denotes expression
T10377 2459-2461 IN denotes of
T10378 2462-2465 DT denotes the
T10379 2484-2490 NN denotes allele
T10380 2466-2468 NN denotes Xp
T10381 2469-2475 VBN denotes linked
T10382 2468-2469 HYPH denotes -
T10383 2476-2483 NN denotes Atrx WT
T10384 2491-2495 WDT denotes that
T10385 2499-2507 VBD denotes observed
T10386 2496-2498 PRP denotes we
T10387 2511-2517 JJ denotes unique
T10388 2518-2520 IN denotes to
T10389 2521-2527 JJ denotes female
T10390 2528-2536 NNS denotes carriers
T10391 2537-2539 IN denotes of
T10392 2540-2543 DT denotes the
T10393 2554-2560 NN denotes allele
T10394 2544-2553 JJ denotes Atrx null
T10395 2560-2561 . denotes .
T10396 2561-2882 sentence denotes Perhaps a more likely explanation for this phenomenon stems from experimental observations suggesting that imprinted X-inactivation is not imposed on all precursors of the mouse extraembryonic tissues: A subpopulation of cells may escape this process and make a random “choice” of which X chromosome will be inactivated.
T10397 2562-2569 RB denotes Perhaps
T10398 2616-2621 VBZ denotes stems
T10399 2570-2571 DT denotes a
T10400 2584-2595 NN denotes explanation
T10401 2572-2576 RBR denotes more
T10402 2577-2583 JJ denotes likely
T10403 2596-2599 IN denotes for
T10404 2600-2604 DT denotes this
T10405 2605-2615 NN denotes phenomenon
T10406 2622-2626 IN denotes from
T10407 2627-2639 JJ denotes experimental
T10408 2640-2652 NNS denotes observations
T10409 2653-2663 VBG denotes suggesting
T10410 2664-2668 IN denotes that
T10411 2793-2799 VB denotes escape
T10412 2669-2678 VBN denotes imprinted
T10413 2681-2693 NN denotes inactivation
T10414 2679-2680 NN denotes X
T10415 2680-2681 HYPH denotes -
T10416 2701-2708 VBN denotes imposed
T10417 2694-2696 VBZ denotes is
T10418 2697-2700 RB denotes not
T10419 2709-2711 IN denotes on
T10420 2712-2715 DT denotes all
T10421 2716-2726 NNS denotes precursors
T10422 2727-2729 IN denotes of
T10423 2730-2733 DT denotes the
T10424 2755-2762 NNS denotes tissues
T10425 2734-2739 NN denotes mouse
T10426 2740-2754 JJ denotes extraembryonic
T10427 2762-2764 : denotes :
T10428 2764-2765 DT denotes A
T10429 2766-2779 NN denotes subpopulation
T10430 2780-2782 IN denotes of
T10431 2783-2788 NNS denotes cells
T10432 2789-2792 MD denotes may
T10433 2800-2804 DT denotes this
T10434 2805-2812 NN denotes process
T10435 2813-2816 CC denotes and
T10436 2817-2821 VB denotes make
T10437 2822-2823 DT denotes a
T10438 2832-2838 NN denotes choice
T10439 2824-2830 JJ denotes random
T10440 2831-2832 `` denotes
T10441 2838-2839 '' denotes
T10442 2840-2842 IN denotes of
T10443 2843-2848 WDT denotes which
T10444 2851-2861 NN denotes chromosome
T10445 2849-2850 NN denotes X
T10446 2870-2881 VBN denotes inactivated
T10447 2862-2866 MD denotes will
T10448 2867-2869 VB denotes be
T10449 2881-2882 . denotes .
T10450 2882-3010 sentence denotes On average, 50% of the cells in this randomly inactivating subpopulation would be expected to maintain an active Xp chromosome.
T10451 2883-2885 IN denotes On
T10452 2965-2973 VBN denotes expected
T10453 2886-2893 JJ denotes average
T10454 2893-2895 , denotes ,
T10455 2895-2897 CD denotes 50
T10456 2897-2898 NN denotes %
T10457 2899-2901 IN denotes of
T10458 2902-2905 DT denotes the
T10459 2906-2911 NNS denotes cells
T10460 2912-2914 IN denotes in
T10461 2915-2919 DT denotes this
T10462 2942-2955 NN denotes subpopulation
T10463 2920-2928 RB denotes randomly
T10464 2929-2941 VBG denotes inactivating
T10465 2956-2961 MD denotes would
T10466 2962-2964 VB denotes be
T10467 2974-2976 TO denotes to
T10468 2977-2985 VB denotes maintain
T10469 2986-2988 DT denotes an
T10470 2999-3009 NN denotes chromosome
T10471 2989-2995 JJ denotes active
T10472 2996-2998 NN denotes Xp
T10473 3009-3010 . denotes .
T10474 3010-3226 sentence denotes In support of this hypothesis, it has been demonstrated that expression of paternally transmitted X-linked lacZ [33,34] and GFP [35] transgenes failed to be silenced in a small subpopulation of extraembryonic cells.
T10475 3011-3013 IN denotes In
T10476 3054-3066 VBN denotes demonstrated
T10477 3014-3021 NN denotes support
T10478 3022-3024 IN denotes of
T10479 3025-3029 DT denotes this
T10480 3030-3040 NN denotes hypothesis
T10481 3040-3042 , denotes ,
T10482 3042-3044 PRP denotes it
T10483 3045-3048 VBZ denotes has
T10484 3049-3053 VBN denotes been
T10485 3067-3071 IN denotes that
T10486 3155-3161 VBD denotes failed
T10487 3072-3082 NN denotes expression
T10488 3083-3085 IN denotes of
T10489 3086-3096 RB denotes paternally
T10490 3097-3108 VBN denotes transmitted
T10491 3118-3122 NN denotes lacZ
T10492 3109-3110 NN denotes X
T10493 3111-3117 VBN denotes linked
T10494 3110-3111 HYPH denotes -
T10495 3144-3154 NNS denotes transgenes
T10496 3123-3124 -LRB- denotes [
T10497 3127-3129 CD denotes 34
T10498 3124-3126 CD denotes 33
T10499 3126-3127 , denotes ,
T10500 3129-3130 -RRB- denotes ]
T10501 3131-3134 CC denotes and
T10502 3135-3138 NN denotes GFP
T10503 3139-3140 -LRB- denotes [
T10504 3140-3142 CD denotes 35
T10505 3142-3143 -RRB- denotes ]
T10506 3162-3164 TO denotes to
T10507 3168-3176 VBN denotes silenced
T10508 3165-3167 VB denotes be
T10509 3177-3179 IN denotes in
T10510 3180-3181 DT denotes a
T10511 3188-3201 NN denotes subpopulation
T10512 3182-3187 JJ denotes small
T10513 3202-3204 IN denotes of
T10514 3205-3219 JJ denotes extraembryonic
T10515 3220-3225 NNS denotes cells
T10516 3225-3226 . denotes .
T10517 3226-3420 sentence denotes Further, it has been shown that in a subpopulation of extraembryonic cells, it is the Xm rather than the Xp that undergoes late replication, a molecular correlate of the inactive state [18,36].
T10518 3227-3234 RB denotes Further
T10519 3248-3253 VBN denotes shown
T10520 3234-3236 , denotes ,
T10521 3236-3238 PRP denotes it
T10522 3239-3242 VBZ denotes has
T10523 3243-3247 VBN denotes been
T10524 3254-3258 IN denotes that
T10525 3306-3308 VBZ denotes is
T10526 3259-3261 IN denotes in
T10527 3262-3263 DT denotes a
T10528 3264-3277 NN denotes subpopulation
T10529 3278-3280 IN denotes of
T10530 3281-3295 JJ denotes extraembryonic
T10531 3296-3301 NNS denotes cells
T10532 3301-3303 , denotes ,
T10533 3303-3305 PRP denotes it
T10534 3309-3312 DT denotes the
T10535 3313-3315 NN denotes Xm
T10536 3316-3322 JJ denotes rather
T10537 3323-3327 IN denotes than
T10538 3328-3331 DT denotes the
T10539 3332-3334 NN denotes Xp
T10540 3335-3339 WDT denotes that
T10541 3340-3349 VBZ denotes undergoes
T10542 3350-3354 JJ denotes late
T10543 3355-3366 NN denotes replication
T10544 3366-3368 , denotes ,
T10545 3368-3369 DT denotes a
T10546 3380-3389 NN denotes correlate
T10547 3370-3379 JJ denotes molecular
T10548 3390-3392 IN denotes of
T10549 3393-3396 DT denotes the
T10550 3406-3411 NN denotes state
T10551 3397-3405 JJ denotes inactive
T10552 3412-3413 -LRB- denotes [
T10553 3416-3418 CD denotes 36
T10554 3413-3415 CD denotes 18
T10555 3415-3416 , denotes ,
T10556 3418-3419 -RRB- denotes ]
T10557 3419-3420 . denotes .
T10558 3420-3708 sentence denotes Although initially small and quickly diluted in normal embryos, the cellular subpopulation that inactivates the Xm chromosome could rapidly expand to replace the normally imprinted cells in extraembryonic lineages if the normal silencing of Xp compromises cell growth or differentiation.
T10559 3421-3429 IN denotes Although
T10560 3440-3445 JJ denotes small
T10561 3430-3439 RB denotes initially
T10562 3561-3567 VB denotes expand
T10563 3446-3449 CC denotes and
T10564 3450-3457 RB denotes quickly
T10565 3458-3465 VBN denotes diluted
T10566 3466-3468 IN denotes in
T10567 3469-3475 JJ denotes normal
T10568 3476-3483 NNS denotes embryos
T10569 3483-3485 , denotes ,
T10570 3485-3488 DT denotes the
T10571 3498-3511 NN denotes subpopulation
T10572 3489-3497 JJ denotes cellular
T10573 3512-3516 WDT denotes that
T10574 3517-3528 VBZ denotes inactivates
T10575 3529-3532 DT denotes the
T10576 3536-3546 NN denotes chromosome
T10577 3533-3535 NN denotes Xm
T10578 3547-3552 MD denotes could
T10579 3553-3560 RB denotes rapidly
T10580 3568-3570 TO denotes to
T10581 3571-3578 VB denotes replace
T10582 3579-3582 DT denotes the
T10583 3602-3607 NNS denotes cells
T10584 3583-3591 RB denotes normally
T10585 3592-3601 VBN denotes imprinted
T10586 3608-3610 IN denotes in
T10587 3611-3625 JJ denotes extraembryonic
T10588 3626-3634 NNS denotes lineages
T10589 3635-3637 IN denotes if
T10590 3665-3676 VBZ denotes compromises
T10591 3638-3641 DT denotes the
T10592 3649-3658 NN denotes silencing
T10593 3642-3648 JJ denotes normal
T10594 3659-3661 IN denotes of
T10595 3662-3664 NN denotes Xp
T10596 3677-3681 NN denotes cell
T10597 3682-3688 NN denotes growth
T10598 3689-3691 CC denotes or
T10599 3692-3707 NN denotes differentiation
T10600 3707-3708 . denotes .
T10601 3708-4062 sentence denotes Interestingly, it has been suggested that the size of the population that initially escapes imprinting may range widely (from 0% to 30%), even between genetically identical embryos [37], and this may account for the variable phenotype observed among females bearing Xm-linked mutant alleles of genes essential for normal extraembryonic development [38].
T10602 3709-3722 RB denotes Interestingly
T10603 3736-3745 VBN denotes suggested
T10604 3722-3724 , denotes ,
T10605 3724-3726 PRP denotes it
T10606 3727-3730 VBZ denotes has
T10607 3731-3735 VBN denotes been
T10608 3746-3750 IN denotes that
T10609 3816-3821 VB denotes range
T10610 3751-3754 DT denotes the
T10611 3755-3759 NN denotes size
T10612 3760-3762 IN denotes of
T10613 3763-3766 DT denotes the
T10614 3767-3777 NN denotes population
T10615 3778-3782 WDT denotes that
T10616 3793-3800 VBZ denotes escapes
T10617 3783-3792 RB denotes initially
T10618 3801-3811 NN denotes imprinting
T10619 3812-3815 MD denotes may
T10620 3822-3828 RB denotes widely
T10621 3829-3830 -LRB- denotes (
T10622 3830-3834 IN denotes from
T10623 3835-3836 CD denotes 0
T10624 3836-3837 NN denotes %
T10625 3838-3840 IN denotes to
T10626 3841-3843 CD denotes 30
T10627 3843-3844 NN denotes %
T10628 3844-3845 -RRB- denotes )
T10629 3845-3847 , denotes ,
T10630 3847-3851 RB denotes even
T10631 3852-3859 IN denotes between
T10632 3860-3871 RB denotes genetically
T10633 3872-3881 JJ denotes identical
T10634 3882-3889 NNS denotes embryos
T10635 3890-3891 -LRB- denotes [
T10636 3891-3893 CD denotes 37
T10637 3893-3894 -RRB- denotes ]
T10638 3894-3896 , denotes ,
T10639 3896-3899 CC denotes and
T10640 3900-3904 DT denotes this
T10641 3909-3916 VB denotes account
T10642 3905-3908 MD denotes may
T10643 3917-3920 IN denotes for
T10644 3921-3924 DT denotes the
T10645 3934-3943 NN denotes phenotype
T10646 3925-3933 JJ denotes variable
T10647 3944-3952 VBN denotes observed
T10648 3953-3958 IN denotes among
T10649 3959-3966 NNS denotes females
T10650 3967-3974 VBG denotes bearing
T10651 3975-3977 NN denotes Xm
T10652 3978-3984 VBN denotes linked
T10653 3977-3978 HYPH denotes -
T10654 3992-3999 NNS denotes alleles
T10655 3985-3991 NN denotes mutant
T10656 4000-4002 IN denotes of
T10657 4003-4008 NNS denotes genes
T10658 4009-4018 JJ denotes essential
T10659 4019-4022 IN denotes for
T10660 4023-4029 JJ denotes normal
T10661 4045-4056 NN denotes development
T10662 4030-4044 JJ denotes extraembryonic
T10663 4057-4058 -LRB- denotes [
T10664 4058-4060 CD denotes 38
T10665 4060-4061 -RRB- denotes ]
T10666 4061-4062 . denotes .
T10667 4062-4215 sentence denotes Put simply, carrier females bearing a small initial population of escaping cells would be more severely affected than those bearing a larger population.
T10668 4063-4066 VBN denotes Put
T10669 4150-4152 VB denotes be
T10670 4067-4073 RB denotes simply
T10671 4073-4075 , denotes ,
T10672 4075-4082 NN denotes carrier
T10673 4083-4090 NNS denotes females
T10674 4091-4098 VBG denotes bearing
T10675 4099-4100 DT denotes a
T10676 4115-4125 NN denotes population
T10677 4101-4106 JJ denotes small
T10678 4107-4114 JJ denotes initial
T10679 4126-4128 IN denotes of
T10680 4129-4137 VBG denotes escaping
T10681 4138-4143 NNS denotes cells
T10682 4144-4149 MD denotes would
T10683 4153-4157 RBR denotes more
T10684 4158-4166 RB denotes severely
T10685 4167-4175 VBN denotes affected
T10686 4176-4180 IN denotes than
T10687 4181-4186 DT denotes those
T10688 4187-4194 VBG denotes bearing
T10689 4195-4196 DT denotes a
T10690 4204-4214 NN denotes population
T10691 4197-4203 JJR denotes larger
T10692 4214-4215 . denotes .
T10693 4215-4402 sentence denotes This could explain why we have observed significant phenotypic variation among Atrx carrier females, with some carriers dying in utero by 9.5 dpc (Table 1) and others developing to term.
T10694 4216-4220 DT denotes This
T10695 4227-4234 VB denotes explain
T10696 4221-4226 MD denotes could
T10697 4235-4238 WRB denotes why
T10698 4247-4255 VBN denotes observed
T10699 4239-4241 PRP denotes we
T10700 4242-4246 VBP denotes have
T10701 4256-4267 JJ denotes significant
T10702 4279-4288 NN denotes variation
T10703 4268-4278 JJ denotes phenotypic
T10704 4289-4294 IN denotes among
T10705 4295-4299 NN denotes Atrx
T10706 4300-4307 NN denotes carrier
T10707 4308-4315 NNS denotes females
T10708 4315-4317 , denotes ,
T10709 4317-4321 IN denotes with
T10710 4322-4326 DT denotes some
T10711 4327-4335 NNS denotes carriers
T10712 4336-4341 VBG denotes dying
T10713 4342-4344 FW denotes in
T10714 4345-4350 FW denotes utero
T10715 4351-4353 IN denotes by
T10716 4354-4357 CD denotes 9.5
T10717 4358-4361 NNS denotes dpc
T10718 4362-4363 -LRB- denotes (
T10719 4363-4368 NN denotes Table
T10720 4369-4370 CD denotes 1
T10721 4370-4371 -RRB- denotes )
T10722 4372-4375 CC denotes and
T10723 4376-4382 NNS denotes others
T10724 4383-4393 VBG denotes developing
T10725 4394-4396 IN denotes to
T10726 4397-4401 NN denotes term
T10727 4401-4402 . denotes .
T10728 4402-4571 sentence denotes Another possible mechanism is that inactivation of the paternal X proceeds normally in all cells, but subsequently the Atrx gene within individual cells is reactivated.
T10729 4403-4410 DT denotes Another
T10730 4420-4429 NN denotes mechanism
T10731 4411-4419 JJ denotes possible
T10732 4430-4432 VBZ denotes is
T10733 4433-4437 IN denotes that
T10734 4469-4477 VBZ denotes proceeds
T10735 4438-4450 NN denotes inactivation
T10736 4451-4453 IN denotes of
T10737 4454-4457 DT denotes the
T10738 4467-4468 NN denotes X
T10739 4458-4466 JJ denotes paternal
T10740 4478-4486 RB denotes normally
T10741 4487-4489 IN denotes in
T10742 4490-4493 DT denotes all
T10743 4494-4499 NNS denotes cells
T10744 4499-4501 , denotes ,
T10745 4501-4504 CC denotes but
T10746 4505-4517 RB denotes subsequently
T10747 4559-4570 VBN denotes reactivated
T10748 4518-4521 DT denotes the
T10749 4527-4531 NN denotes gene
T10750 4522-4526 NN denotes Atrx
T10751 4532-4538 IN denotes within
T10752 4539-4549 JJ denotes individual
T10753 4550-4555 NNS denotes cells
T10754 4556-4558 VBZ denotes is
T10755 4570-4571 . denotes .
T10756 4571-4684 sentence denotes Alternatively, in the absence of Atrx, the paternal allele may partially escape the normal process of silencing.
T10757 4572-4585 RB denotes Alternatively
T10758 4645-4651 VB denotes escape
T10759 4585-4587 , denotes ,
T10760 4587-4589 IN denotes in
T10761 4590-4593 DT denotes the
T10762 4594-4601 NN denotes absence
T10763 4602-4604 IN denotes of
T10764 4605-4609 NN denotes Atrx
T10765 4609-4611 , denotes ,
T10766 4611-4614 DT denotes the
T10767 4624-4630 NN denotes allele
T10768 4615-4623 JJ denotes paternal
T10769 4631-4634 MD denotes may
T10770 4635-4644 RB denotes partially
T10771 4652-4655 DT denotes the
T10772 4663-4670 NN denotes process
T10773 4656-4662 JJ denotes normal
T10774 4671-4673 IN denotes of
T10775 4674-4683 NN denotes silencing
T10776 4683-4684 . denotes .
T10777 4684-4938 sentence denotes In both of these cases, other genes on the paternal X chromosome must be inactivated and remain so, since blocking inactivation of the entire Xp chromosome causes embryonic lethality due to biallelic expression of X-linked genes in the trophoblast [39].
T10778 4685-4687 IN denotes In
T10779 4758-4769 VBN denotes inactivated
T10780 4688-4692 DT denotes both
T10781 4693-4695 IN denotes of
T10782 4696-4701 DT denotes these
T10783 4702-4707 NNS denotes cases
T10784 4707-4709 , denotes ,
T10785 4709-4714 JJ denotes other
T10786 4715-4720 NNS denotes genes
T10787 4721-4723 IN denotes on
T10788 4724-4727 DT denotes the
T10789 4739-4749 NN denotes chromosome
T10790 4728-4736 JJ denotes paternal
T10791 4737-4738 NN denotes X
T10792 4750-4754 MD denotes must
T10793 4755-4757 VB denotes be
T10794 4770-4773 CC denotes and
T10795 4774-4780 VBP denotes remain
T10796 4781-4783 RB denotes so
T10797 4783-4785 , denotes ,
T10798 4785-4790 IN denotes since
T10799 4841-4847 VBZ denotes causes
T10800 4791-4799 VBG denotes blocking
T10801 4800-4812 NN denotes inactivation
T10802 4813-4815 IN denotes of
T10803 4816-4819 DT denotes the
T10804 4830-4840 NN denotes chromosome
T10805 4820-4826 JJ denotes entire
T10806 4827-4829 NN denotes Xp
T10807 4848-4857 JJ denotes embryonic
T10808 4858-4867 NN denotes lethality
T10809 4868-4871 IN denotes due
T10810 4872-4874 IN denotes to
T10811 4875-4884 JJ denotes biallelic
T10812 4885-4895 NN denotes expression
T10813 4896-4898 IN denotes of
T10814 4899-4900 NN denotes X
T10815 4901-4907 VBN denotes linked
T10816 4900-4901 HYPH denotes -
T10817 4908-4913 NNS denotes genes
T10818 4914-4916 IN denotes in
T10819 4917-4920 DT denotes the
T10820 4921-4932 NN denotes trophoblast
T10821 4933-4934 -LRB- denotes [
T10822 4934-4936 CD denotes 39
T10823 4936-4937 -RRB- denotes ]
T10824 4937-4938 . denotes .
R5927 T9932 T9933 nsubj Atrx,Escapes
R5928 T9934 T9935 amod Imprinted,Inactivation
R5929 T9935 T9933 dobj Inactivation,Escapes
R5930 T9936 T9935 compound X,Inactivation
R5931 T9937 T9935 punct -,Inactivation
R5932 T9938 T9933 prep in,Escapes
R5933 T9939 T9940 amod Extraembryonic,Tissues
R5934 T9940 T9938 pobj Tissues,in
R5935 T9941 T9940 prep of,Tissues
R5936 T9942 T9943 nmod Carrier,Mice
R5937 T9943 T9941 pobj Mice,of
R5938 T9944 T9943 amod Female,Mice
R5939 T9946 T9947 det Another,finding
R5940 T9947 T9949 nsubj finding,is
R5941 T9948 T9947 amod surprising,finding
R5942 T9950 T9947 prep of,finding
R5943 T9951 T9952 det this,study
R5944 T9952 T9950 pobj study,of
R5945 T9953 T9954 mark that,appears
R5946 T9954 T9949 ccomp appears,is
R5947 T9955 T9954 punct ", ",appears
R5948 T9956 T9954 prep in,appears
R5949 T9957 T9958 nmod carrier,embryos
R5950 T9958 T9956 pobj embryos,in
R5951 T9959 T9958 amod female,embryos
R5952 T9960 T9954 punct ", ",appears
R5953 T9961 T9962 det a,allele
R5954 T9962 T9954 nsubj allele,appears
R5955 T9963 T9964 advmod paternally,inherited
R5956 T9964 T9962 amod inherited,allele
R5957 T9965 T9962 compound Atrx WT,allele
R5958 T9966 T9967 aux to,escape
R5959 T9967 T9954 xcomp escape,appears
R5960 T9968 T9969 det the,process
R5961 T9969 T9967 dobj process,escape
R5962 T9970 T9969 prep of,process
R5963 T9971 T9972 amod imprinted,inactivation
R5964 T9972 T9970 pobj inactivation,of
R5965 T9973 T9972 compound X,inactivation
R5966 T9974 T9972 punct -,inactivation
R5967 T9975 T9969 punct ", ",process
R5968 T9976 T9977 dep which,silences
R5969 T9977 T9969 relcl silences,process
R5970 T9978 T9977 advmod ordinarily,silences
R5971 T9979 T9980 det the,chromosome
R5972 T9980 T9977 dobj chromosome,silences
R5973 T9981 T9980 compound Xp,chromosome
R5974 T9982 T9977 prep in,silences
R5975 T9983 T9984 det the,compartment
R5976 T9984 T9982 pobj compartment,in
R5977 T9985 T9984 amod extraembryonic,compartment
R5978 T9986 T9984 prep of,compartment
R5979 T9987 T9988 amod female,tissues
R5980 T9988 T9986 pobj tissues,of
R5981 T9989 T9988 amod murine,tissues
R5982 T9990 T9991 punct [,18
R5983 T9991 T9949 parataxis 18,is
R5984 T9992 T9991 punct ],18
R5985 T9993 T9949 punct .,is
R5986 T9995 T9996 nsubj Silencing,render
R5987 T9997 T9995 prep of,Silencing
R5988 T9998 T9999 det the,allele
R5989 T9999 T9997 pobj allele,of
R5990 T10000 T9999 compound Atrx WT,allele
R5991 T10001 T9995 prep on,Silencing
R5992 T10002 T10001 pobj Xp,on
R5993 T10003 T9996 aux should,render
R5994 T10004 T10005 det these,females
R5995 T10005 T9996 dobj females,render
R5996 T10006 T9996 oprd null,render
R5997 T10007 T10006 prep for,null
R5998 T10008 T10007 pobj Atrx,for
R5999 T10009 T9996 prep in,render
R6000 T10010 T10011 det the,tissues
R6001 T10011 T10009 pobj tissues,in
R6002 T10012 T10011 amod extraembryonic,tissues
R6003 T10013 T9996 punct ", ",render
R6004 T10014 T10015 mark since,carries
R6005 T10015 T9996 advcl carries,render
R6006 T10016 T10017 det the,chromosome
R6007 T10017 T10015 nsubj chromosome,carries
R6008 T10018 T10019 advmod normally,active
R6009 T10019 T10017 amod active,chromosome
R6010 T10020 T10017 compound Xm,chromosome
R6011 T10021 T10022 det the,allele
R6012 T10022 T10015 dobj allele,carries
R6013 T10023 T10022 compound Atrx Δ18Δneo,allele
R6014 T10024 T9996 punct .,render
R6015 T10026 T10027 mark Although,normal
R6016 T10027 T10030 advcl normal,developed
R6017 T10028 T10027 neg not,normal
R6018 T10029 T10027 advmod phenotypically,normal
R6019 T10031 T10030 punct ", ",developed
R6020 T10032 T10033 det some,females
R6021 T10033 T10030 nsubj females,developed
R6022 T10034 T10033 compound Atrx,females
R6023 T10035 T10033 compound carrier,females
R6024 T10036 T10030 prep to,developed
R6025 T10037 T10036 pobj term,to
R6026 T10038 T10030 cc and,developed
R6027 T10039 T10030 conj went,developed
R6028 T10040 T10039 prt on,went
R6029 T10041 T10042 aux to,reproduce
R6030 T10042 T10039 xcomp reproduce,went
R6031 T10043 T10030 punct .,developed
R6032 T10045 T10046 advmod Thus,is
R6033 T10047 T10046 punct ", ",is
R6034 T10048 T10049 det the,failure
R6035 T10049 T10046 nsubj failure,is
R6036 T10050 T10051 aux to,silence
R6037 T10051 T10049 acl silence,failure
R6038 T10052 T10051 advmod correctly,silence
R6039 T10053 T10054 det the,allele
R6040 T10054 T10051 dobj allele,silence
R6041 T10055 T10056 advmod paternally,derived
R6042 T10056 T10054 amod derived,allele
R6043 T10057 T10054 compound Atrx WT,allele
R6044 T10058 T10054 prep in,allele
R6045 T10059 T10060 det the,tissues
R6046 T10060 T10058 pobj tissues,in
R6047 T10061 T10060 amod extraembryonic,tissues
R6048 T10062 T10060 prep of,tissues
R6049 T10063 T10064 compound carrier,females
R6050 T10064 T10062 pobj females,of
R6051 T10065 T10046 acomp consistent,is
R6052 T10066 T10065 prep with,consistent
R6053 T10067 T10068 poss our,observations
R6054 T10068 T10066 pobj observations,with
R6055 T10069 T10070 mark that,plays
R6056 T10070 T10068 acl plays,observations
R6057 T10071 T10070 prep in,plays
R6058 T10072 T10073 amod Atrxnull,males
R6059 T10073 T10071 pobj males,in
R6060 T10074 T10070 punct ", ",plays
R6061 T10075 T10076 det the,protein
R6062 T10076 T10070 nsubj protein,plays
R6063 T10077 T10076 compound Atrx,protein
R6064 T10078 T10079 det an,role
R6065 T10079 T10070 dobj role,plays
R6066 T10080 T10079 amod essential,role
R6067 T10081 T10070 prep in,plays
R6068 T10082 T10083 det the,development
R6069 T10083 T10081 pobj development,in
R6070 T10084 T10083 prep of,development
R6071 T10085 T10086 det the,trophoblast
R6072 T10086 T10084 pobj trophoblast,of
R6073 T10087 T10070 cc and,plays
R6074 T10088 T10070 conj is,plays
R6075 T10089 T10088 acomp necessary,is
R6076 T10090 T10089 prep for,necessary
R6077 T10091 T10090 pobj survival,for
R6078 T10092 T10093 advmod in,utero
R6079 T10093 T10091 advmod utero,survival
R6080 T10094 T10088 prep in,is
R6081 T10095 T10096 det the,mouse
R6082 T10096 T10094 pobj mouse,in
R6083 T10097 T10046 punct .,is
R6084 T10099 T10100 det The,survival
R6085 T10100 T10101 nsubj survival,contrasts
R6086 T10102 T10100 prep of,survival
R6087 T10103 T10104 compound Atrx,females
R6088 T10104 T10102 pobj females,of
R6089 T10105 T10104 compound carrier,females
R6090 T10106 T10101 prep with,contrasts
R6091 T10107 T10108 det the,phenotypes
R6092 T10108 T10106 pobj phenotypes,with
R6093 T10109 T10108 acl seen,phenotypes
R6094 T10110 T10109 prep in,seen
R6095 T10111 T10110 pobj carriers,in
R6096 T10112 T10111 prep of,carriers
R6097 T10113 T10112 pobj mutations,of
R6098 T10114 T10113 prep of,mutations
R6099 T10115 T10116 amod other,genes
R6100 T10116 T10114 pobj genes,of
R6101 T10117 T10116 amod murine,genes
R6102 T10118 T10119 npadvmod X,linked
R6103 T10119 T10116 amod linked,genes
R6104 T10120 T10119 punct -,linked
R6105 T10121 T10116 acl known,genes
R6106 T10122 T10123 aux to,be
R6107 T10123 T10121 xcomp be,known
R6108 T10124 T10123 acomp essential,be
R6109 T10125 T10123 prep in,be
R6110 T10126 T10127 det the,compartment
R6111 T10127 T10125 pobj compartment,in
R6112 T10128 T10127 amod extraembryonic,compartment
R6113 T10129 T10101 punct .,contrasts
R6114 T10131 T10132 prep For,cause
R6115 T10133 T10131 pobj example,For
R6116 T10134 T10132 punct ", ",cause
R6117 T10135 T10136 amod targeted,disruption
R6118 T10136 T10132 nsubj disruption,cause
R6119 T10137 T10136 prep of,disruption
R6120 T10138 T10139 det the,genes
R6121 T10139 T10137 pobj genes,of
R6122 T10140 T10139 nmod dyskerin,genes
R6123 T10141 T10140 punct (,dyskerin
R6124 T10142 T10140 appos Dkc1,dyskerin
R6125 T10143 T10140 punct ),dyskerin
R6126 T10144 T10140 punct ", ",dyskerin
R6127 T10145 T10146 nmod glucose,phosphate
R6128 T10146 T10149 compound phosphate,dehydrogenase
R6129 T10147 T10146 nummod 6,phosphate
R6130 T10148 T10146 punct -,phosphate
R6131 T10149 T10140 conj dehydrogenase,dyskerin
R6132 T10150 T10149 punct (,dehydrogenase
R6133 T10151 T10149 appos G6PD,dehydrogenase
R6134 T10152 T10149 punct ),dehydrogenase
R6135 T10153 T10149 punct ", ",dehydrogenase
R6136 T10154 T10149 cc and,dehydrogenase
R6137 T10155 T10149 conj choroideremia,dehydrogenase
R6138 T10156 T10155 punct (,choroideremia
R6139 T10157 T10155 appos Chm,choroideremia
R6140 T10158 T10139 punct ),genes
R6141 T10159 T10160 amod embryonic,lethality
R6142 T10160 T10132 dobj lethality,cause
R6143 T10161 T10160 prep in,lethality
R6144 T10162 T10163 amod null,embryos
R6145 T10163 T10161 pobj embryos,in
R6146 T10164 T10163 amod male,embryos
R6147 T10165 T10132 prep through,cause
R6148 T10166 T10165 pobj defects,through
R6149 T10167 T10166 prep of,defects
R6150 T10168 T10169 det the,tissues
R6151 T10169 T10167 pobj tissues,of
R6152 T10170 T10171 amod extraembryonic,derived
R6153 T10171 T10169 amod derived,tissues
R6154 T10172 T10171 punct -,derived
R6155 T10173 T10174 punct [,29
R6156 T10174 T10132 parataxis 29,cause
R6157 T10175 T10176 punct –,31
R6158 T10176 T10174 prep 31,29
R6159 T10177 T10174 punct ],29
R6160 T10178 T10132 punct .,cause
R6161 T10180 T10181 amod Female,mice
R6162 T10181 T10182 nsubj mice,die
R6163 T10183 T10181 acl carrying,mice
R6164 T10184 T10183 dobj mutations,carrying
R6165 T10185 T10184 prep of,mutations
R6166 T10186 T10187 det these,genes
R6167 T10187 T10185 pobj genes,of
R6168 T10188 T10184 prep on,mutations
R6169 T10189 T10190 det the,chromosome
R6170 T10190 T10188 pobj chromosome,on
R6171 T10191 T10192 advmod maternally,inherited
R6172 T10192 T10190 amod inherited,chromosome
R6173 T10193 T10190 compound X,chromosome
R6174 T10194 T10182 advmod also,die
R6175 T10195 T10196 advmod in,utero
R6176 T10196 T10182 advmod utero,die
R6177 T10197 T10182 punct ", ",die
R6178 T10198 T10199 mark whereas,survive
R6179 T10199 T10182 advcl survive,die
R6180 T10200 T10199 nsubj females,survive
R6181 T10201 T10202 dep that,inherit
R6182 T10202 T10200 relcl inherit,females
R6183 T10203 T10204 det the,mutation
R6184 T10204 T10202 dobj mutation,inherit
R6185 T10205 T10204 prep on,mutation
R6186 T10206 T10207 det the,chromosome
R6187 T10207 T10205 pobj chromosome,on
R6188 T10208 T10207 compound Xp,chromosome
R6189 T10209 T10182 punct .,die
R6190 T10211 T10212 advmod Thus,are
R6191 T10213 T10212 punct ", ",are
R6192 T10214 T10212 prep unlike,are
R6193 T10215 T10214 pobj Atrx,unlike
R6194 T10216 T10212 punct ", ",are
R6195 T10217 T10218 det these,genes
R6196 T10218 T10212 nsubj genes,are
R6197 T10219 T10218 cc and,genes
R6198 T10220 T10219 punct /,and
R6199 T10221 T10219 cc or,and
R6200 T10222 T10223 poss their,effects
R6201 T10223 T10218 conj effects,genes
R6202 T10224 T10223 prep on,effects
R6203 T10225 T10226 compound cell,growth
R6204 T10226 T10224 pobj growth,on
R6205 T10227 T10212 acomp unable,are
R6206 T10228 T10229 aux to,circumvent
R6207 T10229 T10227 xcomp circumvent,unable
R6208 T10230 T10231 det the,processes
R6209 T10231 T10229 dobj processes,circumvent
R6210 T10232 T10233 dep that,cause
R6211 T10233 T10231 relcl cause,processes
R6212 T10234 T10233 advmod ultimately,cause
R6213 T10235 T10236 det all,cells
R6214 T10236 T10237 nsubj cells,express
R6215 T10237 T10233 ccomp express,cause
R6216 T10238 T10236 prep in,cells
R6217 T10239 T10240 det the,tissues
R6218 T10240 T10238 pobj tissues,in
R6219 T10241 T10240 amod extraembryonic,tissues
R6220 T10242 T10237 aux to,express
R6221 T10243 T10244 advmod only,chromosome
R6222 T10244 T10237 dobj chromosome,express
R6223 T10245 T10244 det the,chromosome
R6224 T10246 T10247 advmod maternally,derived
R6225 T10247 T10244 amod derived,chromosome
R6226 T10248 T10244 compound X,chromosome
R6227 T10249 T10212 punct .,are
R6228 T10251 T10252 advmod How,maintained
R6229 T10253 T10252 aux might,maintained
R6230 T10254 T10252 nsubjpass expression,maintained
R6231 T10255 T10254 prep of,expression
R6232 T10256 T10257 det the,allele
R6233 T10257 T10255 pobj allele,of
R6234 T10258 T10259 amod paternal,Atrx WT
R6235 T10259 T10257 compound Atrx WT,allele
R6236 T10260 T10252 auxpass be,maintained
R6237 T10261 T10252 prep in,maintained
R6238 T10262 T10263 det the,tissues
R6239 T10263 T10261 pobj tissues,in
R6240 T10264 T10263 amod extraembryonic,tissues
R6241 T10265 T10263 prep of,tissues
R6242 T10266 T10267 det the,females
R6243 T10267 T10265 pobj females,of
R6244 T10268 T10269 compound Atrx,carrier
R6245 T10269 T10267 compound carrier,females
R6246 T10270 T10252 punct ?,maintained
R6247 T10272 T10273 nummod One,possibility
R6248 T10273 T10274 nsubj possibility,is
R6249 T10275 T10276 mark that,is
R6250 T10276 T10274 ccomp is,is
R6251 T10277 T10276 punct ", ",is
R6252 T10278 T10276 prep like,is
R6253 T10279 T10280 det some,genes
R6254 T10280 T10278 pobj genes,like
R6255 T10281 T10280 amod other,genes
R6256 T10282 T10283 npadvmod X,linked
R6257 T10283 T10280 amod linked,genes
R6258 T10284 T10283 punct -,linked
R6259 T10285 T10276 punct ", ",is
R6260 T10286 T10276 nsubj silencing,is
R6261 T10287 T10286 prep of,silencing
R6262 T10288 T10289 det the,gene
R6263 T10289 T10287 pobj gene,of
R6264 T10290 T10289 compound Atrx,gene
R6265 T10291 T10289 prep on,gene
R6266 T10292 T10291 pobj Xp,on
R6267 T10293 T10276 acomp incomplete,is
R6268 T10294 T10276 punct ", ",is
R6269 T10295 T10296 amod such,is
R6270 T10296 T10276 advcl is,is
R6271 T10297 T10296 mark that,is
R6272 T10298 T10296 expl there,is
R6273 T10299 T10296 advmod always,is
R6274 T10300 T10301 det a,output
R6275 T10301 T10296 attr output,is
R6276 T10302 T10303 amod low,level
R6277 T10303 T10301 nmod level,output
R6278 T10304 T10303 punct -,level
R6279 T10305 T10301 punct ", ",output
R6280 T10306 T10301 amod leaky,output
R6281 T10307 T10301 prep of,output
R6282 T10308 T10307 pobj Atrx,of
R6283 T10309 T10301 prep from,output
R6284 T10310 T10311 det a,chromosome
R6285 T10311 T10309 pobj chromosome,from
R6286 T10312 T10313 advmod normally,inactivated
R6287 T10313 T10311 amod inactivated,chromosome
R6288 T10314 T10311 compound Xp,chromosome
R6289 T10315 T10296 prep in,is
R6290 T10316 T10317 amod extraembryonic,tissues
R6291 T10317 T10315 pobj tissues,in
R6292 T10318 T10274 punct .,is
R6293 T10320 T10321 advmod However,demonstrated
R6294 T10322 T10321 punct ", ",demonstrated
R6295 T10323 T10321 nsubjpass it,demonstrated
R6296 T10324 T10321 auxpass was,demonstrated
R6297 T10325 T10321 advmod recently,demonstrated
R6298 T10326 T10327 mark that,silenced
R6299 T10327 T10321 ccomp silenced,demonstrated
R6300 T10328 T10329 det the,allele
R6301 T10329 T10327 nsubjpass allele,silenced
R6302 T10330 T10331 amod paternal,Atrx
R6303 T10331 T10329 nmod Atrx,allele
R6304 T10332 T10331 punct (,Atrx
R6305 T10333 T10331 acl called,Atrx
R6306 T10334 T10333 oprd Xnp,called
R6307 T10335 T10329 punct ),allele
R6308 T10336 T10327 auxpass is,silenced
R6309 T10337 T10327 advmod completely,silenced
R6310 T10338 T10327 prep in,silenced
R6311 T10339 T10340 det a,line
R6312 T10340 T10338 pobj line,in
R6313 T10341 T10340 amod normal,line
R6314 T10342 T10343 compound mouse,trophoblast
R6315 T10343 T10340 compound trophoblast,line
R6316 T10344 T10345 compound stem,cell
R6317 T10345 T10340 compound cell,line
R6318 T10346 T10347 punct [,32
R6319 T10347 T10321 parataxis 32,demonstrated
R6320 T10348 T10347 punct ],32
R6321 T10349 T10321 punct ", ",demonstrated
R6322 T10350 T10321 advcl suggesting,demonstrated
R6323 T10351 T10352 mark that,escape
R6324 T10352 T10350 ccomp escape,suggesting
R6325 T10353 T10352 nsubj Atrx,escape
R6326 T10354 T10352 aux does,escape
R6327 T10355 T10352 neg not,escape
R6328 T10356 T10352 advmod normally,escape
R6329 T10357 T10358 amod imprinted,inactivation
R6330 T10358 T10352 dobj inactivation,escape
R6331 T10359 T10358 compound X,inactivation
R6332 T10360 T10358 punct -,inactivation
R6333 T10361 T10358 prep in,inactivation
R6334 T10362 T10363 det the,tissues
R6335 T10363 T10361 pobj tissues,in
R6336 T10364 T10363 amod extraembryonic,tissues
R6337 T10365 T10363 prep of,tissues
R6338 T10366 T10367 amod wild,type
R6339 T10367 T10369 compound type,females
R6340 T10368 T10367 punct -,type
R6341 T10369 T10365 pobj females,of
R6342 T10370 T10321 punct .,demonstrated
R6343 T10372 T10373 advmod Thus,is
R6344 T10374 T10373 punct ", ",is
R6345 T10375 T10376 det the,expression
R6346 T10376 T10373 nsubj expression,is
R6347 T10377 T10376 prep of,expression
R6348 T10378 T10379 det the,allele
R6349 T10379 T10377 pobj allele,of
R6350 T10380 T10381 npadvmod Xp,linked
R6351 T10381 T10379 amod linked,allele
R6352 T10382 T10381 punct -,linked
R6353 T10383 T10379 compound Atrx WT,allele
R6354 T10384 T10385 dep that,observed
R6355 T10385 T10379 relcl observed,allele
R6356 T10386 T10385 nsubj we,observed
R6357 T10387 T10373 acomp unique,is
R6358 T10388 T10387 prep to,unique
R6359 T10389 T10390 amod female,carriers
R6360 T10390 T10388 pobj carriers,to
R6361 T10391 T10390 prep of,carriers
R6362 T10392 T10393 det the,allele
R6363 T10393 T10391 pobj allele,of
R6364 T10394 T10393 amod Atrx null,allele
R6365 T10395 T10373 punct .,is
R6366 T10397 T10398 advmod Perhaps,stems
R6367 T10399 T10400 det a,explanation
R6368 T10400 T10398 nsubj explanation,stems
R6369 T10401 T10402 advmod more,likely
R6370 T10402 T10400 amod likely,explanation
R6371 T10403 T10400 prep for,explanation
R6372 T10404 T10405 det this,phenomenon
R6373 T10405 T10403 pobj phenomenon,for
R6374 T10406 T10398 prep from,stems
R6375 T10407 T10408 amod experimental,observations
R6376 T10408 T10406 pobj observations,from
R6377 T10409 T10408 acl suggesting,observations
R6378 T10410 T10411 mark that,escape
R6379 T10411 T10409 ccomp escape,suggesting
R6380 T10412 T10413 amod imprinted,inactivation
R6381 T10413 T10416 nsubjpass inactivation,imposed
R6382 T10414 T10413 compound X,inactivation
R6383 T10415 T10413 punct -,inactivation
R6384 T10416 T10411 ccomp imposed,escape
R6385 T10417 T10416 auxpass is,imposed
R6386 T10418 T10416 neg not,imposed
R6387 T10419 T10416 prep on,imposed
R6388 T10420 T10421 det all,precursors
R6389 T10421 T10419 pobj precursors,on
R6390 T10422 T10421 prep of,precursors
R6391 T10423 T10424 det the,tissues
R6392 T10424 T10422 pobj tissues,of
R6393 T10425 T10424 nmod mouse,tissues
R6394 T10426 T10425 amod extraembryonic,mouse
R6395 T10427 T10411 punct : ,escape
R6396 T10428 T10429 det A,subpopulation
R6397 T10429 T10411 nsubj subpopulation,escape
R6398 T10430 T10429 prep of,subpopulation
R6399 T10431 T10430 pobj cells,of
R6400 T10432 T10411 aux may,escape
R6401 T10433 T10434 det this,process
R6402 T10434 T10411 dobj process,escape
R6403 T10435 T10411 cc and,escape
R6404 T10436 T10411 conj make,escape
R6405 T10437 T10438 det a,choice
R6406 T10438 T10436 dobj choice,make
R6407 T10439 T10438 amod random,choice
R6408 T10440 T10438 punct “,choice
R6409 T10441 T10438 punct ”,choice
R6410 T10442 T10438 prep of,choice
R6411 T10443 T10444 det which,chromosome
R6412 T10444 T10446 dep chromosome,inactivated
R6413 T10445 T10444 compound X,chromosome
R6414 T10446 T10442 pcomp inactivated,of
R6415 T10447 T10446 aux will,inactivated
R6416 T10448 T10446 auxpass be,inactivated
R6417 T10449 T10398 punct .,stems
R6418 T10451 T10452 prep On,expected
R6419 T10453 T10451 amod average,On
R6420 T10454 T10452 punct ", ",expected
R6421 T10455 T10456 nummod 50,%
R6422 T10456 T10452 nsubjpass %,expected
R6423 T10457 T10456 prep of,%
R6424 T10458 T10459 det the,cells
R6425 T10459 T10457 pobj cells,of
R6426 T10460 T10456 prep in,%
R6427 T10461 T10462 det this,subpopulation
R6428 T10462 T10460 pobj subpopulation,in
R6429 T10463 T10464 advmod randomly,inactivating
R6430 T10464 T10462 amod inactivating,subpopulation
R6431 T10465 T10452 aux would,expected
R6432 T10466 T10452 auxpass be,expected
R6433 T10467 T10468 aux to,maintain
R6434 T10468 T10452 xcomp maintain,expected
R6435 T10469 T10470 det an,chromosome
R6436 T10470 T10468 dobj chromosome,maintain
R6437 T10471 T10470 amod active,chromosome
R6438 T10472 T10470 compound Xp,chromosome
R6439 T10473 T10452 punct .,expected
R6440 T10475 T10476 prep In,demonstrated
R6441 T10477 T10475 pobj support,In
R6442 T10478 T10477 prep of,support
R6443 T10479 T10480 det this,hypothesis
R6444 T10480 T10478 pobj hypothesis,of
R6445 T10481 T10476 punct ", ",demonstrated
R6446 T10482 T10476 nsubjpass it,demonstrated
R6447 T10483 T10476 aux has,demonstrated
R6448 T10484 T10476 auxpass been,demonstrated
R6449 T10485 T10486 mark that,failed
R6450 T10486 T10476 ccomp failed,demonstrated
R6451 T10487 T10486 nsubj expression,failed
R6452 T10488 T10487 prep of,expression
R6453 T10489 T10490 advmod paternally,transmitted
R6454 T10490 T10491 amod transmitted,lacZ
R6455 T10491 T10495 nmod lacZ,transgenes
R6456 T10492 T10493 npadvmod X,linked
R6457 T10493 T10491 amod linked,lacZ
R6458 T10494 T10493 punct -,linked
R6459 T10495 T10488 pobj transgenes,of
R6460 T10496 T10497 punct [,34
R6461 T10497 T10491 parataxis 34,lacZ
R6462 T10498 T10497 nummod 33,34
R6463 T10499 T10497 punct ",",34
R6464 T10500 T10497 punct ],34
R6465 T10501 T10491 cc and,lacZ
R6466 T10502 T10491 conj GFP,lacZ
R6467 T10503 T10504 punct [,35
R6468 T10504 T10502 parataxis 35,GFP
R6469 T10505 T10504 punct ],35
R6470 T10506 T10507 aux to,silenced
R6471 T10507 T10486 xcomp silenced,failed
R6472 T10508 T10507 auxpass be,silenced
R6473 T10509 T10507 prep in,silenced
R6474 T10510 T10511 det a,subpopulation
R6475 T10511 T10509 pobj subpopulation,in
R6476 T10512 T10511 amod small,subpopulation
R6477 T10513 T10511 prep of,subpopulation
R6478 T10514 T10515 amod extraembryonic,cells
R6479 T10515 T10513 pobj cells,of
R6480 T10516 T10476 punct .,demonstrated
R6481 T10518 T10519 advmod Further,shown
R6482 T10520 T10519 punct ", ",shown
R6483 T10521 T10519 nsubjpass it,shown
R6484 T10522 T10519 aux has,shown
R6485 T10523 T10519 auxpass been,shown
R6486 T10524 T10525 mark that,is
R6487 T10525 T10519 ccomp is,shown
R6488 T10526 T10525 prep in,is
R6489 T10527 T10528 det a,subpopulation
R6490 T10528 T10526 pobj subpopulation,in
R6491 T10529 T10528 prep of,subpopulation
R6492 T10530 T10531 amod extraembryonic,cells
R6493 T10531 T10529 pobj cells,of
R6494 T10532 T10525 punct ", ",is
R6495 T10533 T10525 nsubj it,is
R6496 T10534 T10535 det the,Xm
R6497 T10535 T10525 attr Xm,is
R6498 T10536 T10537 amod rather,than
R6499 T10537 T10535 cc than,Xm
R6500 T10538 T10539 det the,Xp
R6501 T10539 T10535 conj Xp,Xm
R6502 T10540 T10541 dep that,undergoes
R6503 T10541 T10535 relcl undergoes,Xm
R6504 T10542 T10543 amod late,replication
R6505 T10543 T10541 dobj replication,undergoes
R6506 T10544 T10543 punct ", ",replication
R6507 T10545 T10546 det a,correlate
R6508 T10546 T10543 appos correlate,replication
R6509 T10547 T10546 amod molecular,correlate
R6510 T10548 T10546 prep of,correlate
R6511 T10549 T10550 det the,state
R6512 T10550 T10548 pobj state,of
R6513 T10551 T10550 amod inactive,state
R6514 T10552 T10553 punct [,36
R6515 T10553 T10525 parataxis 36,is
R6516 T10554 T10553 nummod 18,36
R6517 T10555 T10553 punct ",",36
R6518 T10556 T10553 punct ],36
R6519 T10557 T10519 punct .,shown
R6520 T10559 T10560 mark Although,small
R6521 T10560 T10562 advcl small,expand
R6522 T10561 T10560 advmod initially,small
R6523 T10563 T10560 cc and,small
R6524 T10564 T10565 advmod quickly,diluted
R6525 T10565 T10560 conj diluted,small
R6526 T10566 T10565 prep in,diluted
R6527 T10567 T10568 amod normal,embryos
R6528 T10568 T10566 pobj embryos,in
R6529 T10569 T10562 punct ", ",expand
R6530 T10570 T10571 det the,subpopulation
R6531 T10571 T10562 nsubj subpopulation,expand
R6532 T10572 T10571 amod cellular,subpopulation
R6533 T10573 T10574 dep that,inactivates
R6534 T10574 T10571 relcl inactivates,subpopulation
R6535 T10575 T10576 det the,chromosome
R6536 T10576 T10574 dobj chromosome,inactivates
R6537 T10577 T10576 compound Xm,chromosome
R6538 T10578 T10562 aux could,expand
R6539 T10579 T10562 advmod rapidly,expand
R6540 T10580 T10581 aux to,replace
R6541 T10581 T10562 advcl replace,expand
R6542 T10582 T10583 det the,cells
R6543 T10583 T10581 dobj cells,replace
R6544 T10584 T10585 advmod normally,imprinted
R6545 T10585 T10583 amod imprinted,cells
R6546 T10586 T10583 prep in,cells
R6547 T10587 T10588 amod extraembryonic,lineages
R6548 T10588 T10586 pobj lineages,in
R6549 T10589 T10590 mark if,compromises
R6550 T10590 T10562 advcl compromises,expand
R6551 T10591 T10592 det the,silencing
R6552 T10592 T10590 nsubj silencing,compromises
R6553 T10593 T10592 amod normal,silencing
R6554 T10594 T10592 prep of,silencing
R6555 T10595 T10594 pobj Xp,of
R6556 T10596 T10597 compound cell,growth
R6557 T10597 T10590 dobj growth,compromises
R6558 T10598 T10597 cc or,growth
R6559 T10599 T10597 conj differentiation,growth
R6560 T10600 T10562 punct .,expand
R6561 T10602 T10603 advmod Interestingly,suggested
R6562 T10604 T10603 punct ", ",suggested
R6563 T10605 T10603 nsubjpass it,suggested
R6564 T10606 T10603 aux has,suggested
R6565 T10607 T10603 auxpass been,suggested
R6566 T10608 T10609 mark that,range
R6567 T10609 T10603 ccomp range,suggested
R6568 T10610 T10611 det the,size
R6569 T10611 T10609 nsubj size,range
R6570 T10612 T10611 prep of,size
R6571 T10613 T10614 det the,population
R6572 T10614 T10612 pobj population,of
R6573 T10615 T10616 dep that,escapes
R6574 T10616 T10614 relcl escapes,population
R6575 T10617 T10616 advmod initially,escapes
R6576 T10618 T10616 dobj imprinting,escapes
R6577 T10619 T10609 aux may,range
R6578 T10620 T10609 advmod widely,range
R6579 T10621 T10609 punct (,range
R6580 T10622 T10609 prep from,range
R6581 T10623 T10624 nummod 0,%
R6582 T10624 T10622 pobj %,from
R6583 T10625 T10622 prep to,from
R6584 T10626 T10627 nummod 30,%
R6585 T10627 T10625 pobj %,to
R6586 T10628 T10609 punct ),range
R6587 T10629 T10609 punct ", ",range
R6588 T10630 T10631 advmod even,between
R6589 T10631 T10609 prep between,range
R6590 T10632 T10633 advmod genetically,identical
R6591 T10633 T10634 amod identical,embryos
R6592 T10634 T10631 pobj embryos,between
R6593 T10635 T10636 punct [,37
R6594 T10636 T10609 parataxis 37,range
R6595 T10637 T10636 punct ],37
R6596 T10638 T10603 punct ", ",suggested
R6597 T10639 T10603 cc and,suggested
R6598 T10640 T10641 nsubj this,account
R6599 T10641 T10603 conj account,suggested
R6600 T10642 T10641 aux may,account
R6601 T10643 T10641 prep for,account
R6602 T10644 T10645 det the,phenotype
R6603 T10645 T10643 pobj phenotype,for
R6604 T10646 T10645 amod variable,phenotype
R6605 T10647 T10645 acl observed,phenotype
R6606 T10648 T10647 prep among,observed
R6607 T10649 T10648 pobj females,among
R6608 T10650 T10649 acl bearing,females
R6609 T10651 T10652 npadvmod Xm,linked
R6610 T10652 T10654 amod linked,alleles
R6611 T10653 T10652 punct -,linked
R6612 T10654 T10650 dobj alleles,bearing
R6613 T10655 T10654 compound mutant,alleles
R6614 T10656 T10654 prep of,alleles
R6615 T10657 T10656 pobj genes,of
R6616 T10658 T10657 amod essential,genes
R6617 T10659 T10658 prep for,essential
R6618 T10660 T10661 amod normal,development
R6619 T10661 T10659 pobj development,for
R6620 T10662 T10661 amod extraembryonic,development
R6621 T10663 T10664 punct [,38
R6622 T10664 T10641 parataxis 38,account
R6623 T10665 T10664 punct ],38
R6624 T10666 T10641 punct .,account
R6625 T10668 T10669 advcl Put,be
R6626 T10670 T10668 advmod simply,Put
R6627 T10671 T10669 punct ", ",be
R6628 T10672 T10673 compound carrier,females
R6629 T10673 T10669 nsubj females,be
R6630 T10674 T10673 acl bearing,females
R6631 T10675 T10676 det a,population
R6632 T10676 T10674 dobj population,bearing
R6633 T10677 T10676 amod small,population
R6634 T10678 T10676 amod initial,population
R6635 T10679 T10676 prep of,population
R6636 T10680 T10681 amod escaping,cells
R6637 T10681 T10679 pobj cells,of
R6638 T10682 T10669 aux would,be
R6639 T10683 T10684 advmod more,severely
R6640 T10684 T10685 advmod severely,affected
R6641 T10685 T10669 acomp affected,be
R6642 T10686 T10685 prep than,affected
R6643 T10687 T10686 pobj those,than
R6644 T10688 T10687 acl bearing,those
R6645 T10689 T10690 det a,population
R6646 T10690 T10688 dobj population,bearing
R6647 T10691 T10690 amod larger,population
R6648 T10692 T10669 punct .,be
R6649 T10694 T10695 nsubj This,explain
R6650 T10696 T10695 aux could,explain
R6651 T10697 T10698 advmod why,observed
R6652 T10698 T10695 ccomp observed,explain
R6653 T10699 T10698 nsubj we,observed
R6654 T10700 T10698 aux have,observed
R6655 T10701 T10702 amod significant,variation
R6656 T10702 T10698 dobj variation,observed
R6657 T10703 T10702 amod phenotypic,variation
R6658 T10704 T10702 prep among,variation
R6659 T10705 T10706 compound Atrx,carrier
R6660 T10706 T10707 compound carrier,females
R6661 T10707 T10704 pobj females,among
R6662 T10708 T10698 punct ", ",observed
R6663 T10709 T10698 prep with,observed
R6664 T10710 T10711 det some,carriers
R6665 T10711 T10712 nsubj carriers,dying
R6666 T10712 T10709 pobj dying,with
R6667 T10713 T10714 advmod in,utero
R6668 T10714 T10712 advmod utero,dying
R6669 T10715 T10712 prep by,dying
R6670 T10716 T10717 nummod 9.5,dpc
R6671 T10717 T10715 pobj dpc,by
R6672 T10718 T10719 punct (,Table
R6673 T10719 T10712 parataxis Table,dying
R6674 T10720 T10719 nummod 1,Table
R6675 T10721 T10719 punct ),Table
R6676 T10722 T10712 cc and,dying
R6677 T10723 T10724 nsubj others,developing
R6678 T10724 T10712 conj developing,dying
R6679 T10725 T10724 prep to,developing
R6680 T10726 T10725 pobj term,to
R6681 T10727 T10695 punct .,explain
R6682 T10729 T10730 det Another,mechanism
R6683 T10730 T10732 nsubj mechanism,is
R6684 T10731 T10730 amod possible,mechanism
R6685 T10733 T10734 mark that,proceeds
R6686 T10734 T10732 ccomp proceeds,is
R6687 T10735 T10734 nsubj inactivation,proceeds
R6688 T10736 T10735 prep of,inactivation
R6689 T10737 T10738 det the,X
R6690 T10738 T10736 pobj X,of
R6691 T10739 T10738 amod paternal,X
R6692 T10740 T10734 advmod normally,proceeds
R6693 T10741 T10734 prep in,proceeds
R6694 T10742 T10743 det all,cells
R6695 T10743 T10741 pobj cells,in
R6696 T10744 T10734 punct ", ",proceeds
R6697 T10745 T10734 cc but,proceeds
R6698 T10746 T10747 advmod subsequently,reactivated
R6699 T10747 T10734 conj reactivated,proceeds
R6700 T10748 T10749 det the,gene
R6701 T10749 T10747 nsubjpass gene,reactivated
R6702 T10750 T10749 compound Atrx,gene
R6703 T10751 T10749 prep within,gene
R6704 T10752 T10753 amod individual,cells
R6705 T10753 T10751 pobj cells,within
R6706 T10754 T10747 auxpass is,reactivated
R6707 T10755 T10732 punct .,is
R6708 T10757 T10758 advmod Alternatively,escape
R6709 T10759 T10758 punct ", ",escape
R6710 T10760 T10758 prep in,escape
R6711 T10761 T10762 det the,absence
R6712 T10762 T10760 pobj absence,in
R6713 T10763 T10762 prep of,absence
R6714 T10764 T10763 pobj Atrx,of
R6715 T10765 T10758 punct ", ",escape
R6716 T10766 T10767 det the,allele
R6717 T10767 T10758 nsubj allele,escape
R6718 T10768 T10767 amod paternal,allele
R6719 T10769 T10758 aux may,escape
R6720 T10770 T10758 advmod partially,escape
R6721 T10771 T10772 det the,process
R6722 T10772 T10758 dobj process,escape
R6723 T10773 T10772 amod normal,process
R6724 T10774 T10772 prep of,process
R6725 T10775 T10774 pobj silencing,of
R6726 T10776 T10758 punct .,escape
R6727 T10778 T10779 prep In,inactivated
R6728 T10780 T10778 pobj both,In
R6729 T10781 T10780 prep of,both
R6730 T10782 T10783 det these,cases
R6731 T10783 T10781 pobj cases,of
R6732 T10784 T10779 punct ", ",inactivated
R6733 T10785 T10786 amod other,genes
R6734 T10786 T10779 nsubjpass genes,inactivated
R6735 T10787 T10786 prep on,genes
R6736 T10788 T10789 det the,chromosome
R6737 T10789 T10787 pobj chromosome,on
R6738 T10790 T10789 amod paternal,chromosome
R6739 T10791 T10789 compound X,chromosome
R6740 T10792 T10779 aux must,inactivated
R6741 T10793 T10779 auxpass be,inactivated
R6742 T10794 T10779 cc and,inactivated
R6743 T10795 T10779 conj remain,inactivated
R6744 T10796 T10795 advmod so,remain
R6745 T10797 T10779 punct ", ",inactivated
R6746 T10798 T10799 mark since,causes
R6747 T10799 T10779 advcl causes,inactivated
R6748 T10800 T10801 amod blocking,inactivation
R6749 T10801 T10799 nsubj inactivation,causes
R6750 T10802 T10801 prep of,inactivation
R6751 T10803 T10804 det the,chromosome
R6752 T10804 T10802 pobj chromosome,of
R6753 T10805 T10804 amod entire,chromosome
R6754 T10806 T10804 compound Xp,chromosome
R6755 T10807 T10808 amod embryonic,lethality
R6756 T10808 T10799 dobj lethality,causes
R6757 T10809 T10799 prep due,causes
R6758 T10810 T10809 pcomp to,due
R6759 T10811 T10812 amod biallelic,expression
R6760 T10812 T10809 pobj expression,due
R6761 T10813 T10812 prep of,expression
R6762 T10814 T10815 npadvmod X,linked
R6763 T10815 T10817 amod linked,genes
R6764 T10816 T10815 punct -,linked
R6765 T10817 T10813 pobj genes,of
R6766 T10818 T10812 prep in,expression
R6767 T10819 T10820 det the,trophoblast
R6768 T10820 T10818 pobj trophoblast,in
R6769 T10821 T10822 punct [,39
R6770 T10822 T10779 parataxis 39,inactivated
R6771 T10823 T10822 punct ],39
R6772 T10824 T10779 punct .,inactivated

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9728 0-4 PR_EXT:000004503 denotes Atrx
T9729 13-37 GO:0060819 denotes Imprinted X-Inactivation
T9730 23-24 GO:0000805 denotes X
T9731 41-63 UBERON:0005292 denotes Extraembryonic Tissues
T9732 75-81 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Female
T9733 82-86 NCBITaxon:10088 denotes Mice
T9734 148-154 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T9735 155-162 UBERON:0000922 denotes embryos
T9736 187-191 PR_EXT:000004503 denotes Atrx
T9737 192-194 SO_EXT:wild_type_entity_or_quality denotes WT
T9738 195-201 SO_EXT:0001023 denotes allele
T9739 235-259 GO:0060819 denotes imprinted X-inactivation
T9740 245-246 GO:0000805 denotes X
T9741 278-286 GO:0016458 denotes silences
T9742 294-304 GO_SO_EXT:chromosome denotes chromosome
T9743 317-326 UBERON:0000922 denotes embryonic
T9744 342-348 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T9745 349-355 NCBITaxon:39107 denotes murine
T9746 356-363 UBERON:0000479 denotes tissues
T9747 370-379 GO:0016458 denotes Silencing
T9748 387-391 PR_EXT:000004503 denotes Atrx
T9749 392-394 SO_EXT:wild_type_entity_or_quality denotes WT
T9750 395-401 SO_EXT:0001023 denotes allele
T9751 428-435 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9752 436-440 SO_EXT:sequence_nullness denotes null
T9753 445-449 PR_EXT:000004503 denotes Atrx
T9754 457-479 UBERON:0005292 denotes extraembryonic tissues
T9755 510-520 GO_SO_EXT:chromosome denotes chromosome
T9756 533-537 PR_EXT:000004503 denotes Atrx
T9757 546-552 SO_EXT:0001023 denotes allele
T9758 595-599 PR_EXT:000004503 denotes Atrx
T9759 608-615 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9760 649-658 GO:0000003 denotes reproduce
T9761 691-698 GO:0016458 denotes silence
T9762 722-726 PR_EXT:000007899 denotes Atrx
T9763 727-729 SO_EXT:wild_type_entity_or_quality denotes WT
T9764 730-736 SO_EXT:0001023 denotes allele
T9765 744-766 UBERON:0005292 denotes extraembryonic tissues
T9766 778-785 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9767 830-834 PR_EXT:000007899 denotes Atrx
T9768 834-838 SO_EXT:sequence_nullness denotes null
T9769 839-844 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T9770 850-854 PR_EXT:000004503 denotes Atrx
T9771 855-862 CHEBI_PR_EXT:protein denotes protein
T9772 913-924 UBERON:0000088 denotes trophoblast
T9773 971-976 NCBITaxon:10088 denotes mouse
T9774 994-998 PR_EXT:000004503 denotes Atrx
T9775 1007-1014 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9776 1065-1074 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T9777 1084-1090 NCBITaxon:39107 denotes murine
T9778 1091-1092 GO:0000805 denotes X
T9779 1100-1105 SO_EXT:0000704 denotes genes
T9780 1140-1149 UBERON:0000922 denotes embryonic
T9781 1203-1211 PR_EXT:000006498 denotes dyskerin
T9782 1213-1217 PR_EXT:000006498 denotes Dkc1
T9783 1220-1239 CHEBI:14314 denotes glucose 6-phosphate
T9784 1220-1253 GO_PR_EXT:glucose_6_phosphate_dehydrogenase denotes glucose 6-phosphate dehydrogenase
T9785 1255-1259 GO_PR_EXT:glucose_6_phosphate_dehydrogenase denotes G6PD
T9786 1266-1279 PR_EXT:000005430 denotes choroideremia
T9787 1281-1284 PR_EXT:000005430 denotes Chm
T9788 1286-1291 SO_EXT:0000704 denotes genes
T9789 1298-1307 UBERON:0000922 denotes embryonic
T9790 1308-1317 GO_EXT:fatality_or_lethality denotes lethality
T9791 1321-1325 SO_EXT:sequence_nullness denotes null
T9792 1326-1330 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T9793 1331-1338 UBERON:0000922 denotes embryos
T9794 1367-1376 UBERON:0000922 denotes embryonic
T9795 1385-1392 UBERON:0000479 denotes tissues
T9796 1402-1408 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Female
T9797 1409-1413 NCBITaxon:10088 denotes mice
T9798 1423-1432 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T9799 1442-1447 SO_EXT:0000704 denotes genes
T9800 1476-1488 GO:0000805 denotes X chromosome
T9801 1478-1488 GO_SO_EXT:chromosome denotes chromosome
T9802 1494-1497 GO:0016265 denotes die
T9803 1516-1523 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9804 1541-1549 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9805 1560-1570 GO_SO_EXT:chromosome denotes chromosome
T9806 1593-1597 PR_EXT:000004503 denotes Atrx
T9807 1605-1610 SO_EXT:0000704 denotes genes
T9808 1635-1639 CL_GO_EXT:cell denotes cell
T9809 1640-1646 GO_EXT:biological_growth_entity_or_process denotes growth
T9810 1712-1717 CL_GO_EXT:cell denotes cells
T9811 1725-1747 UBERON:0005292 denotes extraembryonic tissues
T9812 1751-1758 GO:0010467 denotes express
T9813 1787-1799 GO:0000805 denotes X chromosome
T9814 1789-1799 GO_SO_EXT:chromosome denotes chromosome
T9815 1811-1821 GO:0010467 denotes expression
T9816 1838-1842 PR_EXT:000004503 denotes Atrx
T9817 1843-1845 SO_EXT:wild_type_entity_or_quality denotes WT
T9818 1846-1852 SO_EXT:0001023 denotes allele
T9819 1874-1896 UBERON:0005292 denotes extraembryonic tissues
T9820 1904-1908 PR_EXT:000004503 denotes Atrx
T9821 1917-1924 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9822 1967-1968 GO:0000805 denotes X
T9823 1976-1981 SO_EXT:0000704 denotes genes
T9824 1983-1995 _FRAGMENT denotes silencing of
T9825 2005-2009 GO:0016458 denotes gene
T9826 2000-2004 PR_EXT:000004503 denotes Atrx
T9827 2005-2009 SO_EXT:0000704 denotes gene
T9828 2086-2090 PR_EXT:000004503 denotes Atrx
T9829 2122-2132 GO_SO_EXT:chromosome denotes chromosome
T9830 2136-2158 UBERON:0005292 denotes extraembryonic tissues
T9831 2216-2220 PR_EXT:000004503 denotes Atrx
T9832 2234-2240 SO_EXT:0001023 denotes allele
T9833 2255-2263 GO:0016458 denotes silenced
T9834 2276-2281 NCBITaxon:10088 denotes mouse
T9835 2282-2293 UBERON:0000088 denotes trophoblast
T9836 2282-2293 _FRAGMENT denotes trophoblast
T9837 2299-2303 CL:0000351 denotes cell
T9838 2294-2303 CL:0000034 denotes stem cell
T9839 2299-2303 CL_GO_EXT:cell denotes cell
T9840 2331-2335 PR_EXT:000004503 denotes Atrx
T9841 2361-2385 GO:0060819 denotes imprinted X-inactivation
T9842 2371-2372 GO:0000805 denotes X
T9843 2393-2415 UBERON:0005292 denotes extraembryonic tissues
T9844 2419-2428 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9845 2429-2436 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9846 2448-2458 GO:0010467 denotes expression
T9847 2476-2480 PR_EXT:000004503 denotes Atrx
T9848 2481-2483 SO_EXT:wild_type_entity_or_quality denotes WT
T9849 2484-2490 SO_EXT:0001023 denotes allele
T9850 2521-2527 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T9851 2544-2548 PR_EXT:000004503 denotes Atrx
T9852 2549-2553 SO_EXT:sequence_nullness denotes null
T9853 2554-2560 SO_EXT:0001023 denotes allele
T9854 2669-2693 GO:0060819 denotes imprinted X-inactivation
T9855 2679-2680 GO:0000805 denotes X
T9856 2734-2739 NCBITaxon:10088 denotes mouse
T9857 2740-2762 UBERON:0005292 denotes extraembryonic tissues
T9858 2769-2788 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes population of cells
T9859 2783-2788 CL_GO_EXT:cell denotes cells
T9860 2849-2861 GO:0000805 denotes X chromosome
T9861 2851-2861 GO_SO_EXT:chromosome denotes chromosome
T9862 2906-2911 CL_GO_EXT:cell denotes cells
T9863 2999-3009 GO_SO_EXT:chromosome denotes chromosome
T9864 3072-3082 GO:0010467 denotes expression
T9865 3109-3110 GO:0000805 denotes X
T9866 3118-3122 PR_EXT:000033987 denotes lacZ
T9867 3144-3154 SO_EXT:0000902 denotes transgenes
T9868 3168-3176 GO:0016458 denotes silenced
T9869 3191-3204 _FRAGMENT denotes population of
T9870 3220-3225 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cells
T9871 3205-3225 CL:0000349 denotes extraembryonic cells
T9872 3210-3219 UBERON:0000922 denotes embryonic
T9873 3220-3225 CL_GO_EXT:cell denotes cells
T9874 3267-3280 _FRAGMENT denotes population of
T9875 3296-3301 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cells
T9876 3281-3301 CL:0000349 denotes extraembryonic cells
T9877 3286-3295 UBERON:0000922 denotes embryonic
T9878 3296-3301 CL_GO_EXT:cell denotes cells
T9879 3355-3366 GO:0006260 denotes replication
T9880 3370-3379 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T9881 3476-3483 UBERON:0000922 denotes embryos
T9882 3489-3497 CL_GO_EXT:cell denotes cellular
T9883 3489-3497 _FRAGMENT denotes cellular
T9884 3501-3511 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes population
T9885 3536-3546 GO_SO_EXT:chromosome denotes chromosome
T9886 3592-3601 GO:0071514 denotes imprinted
T9887 3602-3607 CL_GO_EXT:cell denotes cells
T9888 3616-3625 UBERON:0000922 denotes embryonic
T9889 3649-3658 GO:0016458 denotes silencing
T9890 3677-3681 CL_GO_EXT:cell denotes cell
T9891 3677-3681 _FRAGMENT denotes cell
T9892 3692-3707 GO:0030154 denotes differentiation
T9893 3682-3688 GO_EXT:biological_growth_entity_or_process denotes growth
T9894 3801-3811 GO:0071514 denotes imprinting
T9895 3860-3871 SO_EXT:0000704 denotes genetically
T9896 3882-3889 UBERON:0000922 denotes embryos
T9897 3959-3966 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9898 3985-3991 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9899 3992-3999 SO_EXT:0001023 denotes alleles
T9900 4003-4008 SO_EXT:0000704 denotes genes
T9901 4035-4044 UBERON:0000922 denotes embryonic
T9902 4083-4090 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9903 4115-4128 _FRAGMENT denotes population of
T9904 4138-4143 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cells
T9905 4138-4143 CL_GO_EXT:cell denotes cells
T9906 4295-4299 PR_EXT:000004503 denotes Atrx
T9907 4308-4315 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T9908 4336-4341 GO:0016265 denotes dying
T9909 4438-4453 _FRAGMENT denotes inactivation of
T9910 4458-4468 GO:0060817 denotes paternal X
T9911 4467-4468 GO:0000805 denotes X
T9912 4494-4499 CL_GO_EXT:cell denotes cells
T9913 4522-4526 PR_EXT:000004503 denotes Atrx
T9914 4527-4531 SO_EXT:0000704 denotes gene
T9915 4550-4555 CL_GO_EXT:cell denotes cells
T9916 4605-4609 PR_EXT:000004503 denotes Atrx
T9917 4624-4630 SO_EXT:0001023 denotes allele
T9918 4674-4683 GO:0016458 denotes silencing
T9919 4715-4720 SO_EXT:0000704 denotes genes
T9920 4737-4749 GO:0000805 denotes X chromosome
T9921 4739-4749 GO_SO_EXT:chromosome denotes chromosome
T9922 4800-4815 _FRAGMENT denotes inactivation of
T9923 4827-4840 GO:0060817 denotes Xp chromosome
T9924 4830-4840 GO_SO_EXT:chromosome denotes chromosome
T9925 4848-4857 UBERON:0000922 denotes embryonic
T9926 4858-4867 GO_EXT:fatality_or_lethality denotes lethality
T9927 4877-4884 SO_EXT:0001023 denotes allelic
T9928 4885-4895 GO:0010467 denotes expression
T9929 4899-4900 GO:0000805 denotes X
T9930 4908-4913 SO_EXT:0000704 denotes genes
T9931 4921-4932 UBERON:0000088 denotes trophoblast
R5918 T9825 T9824 _lexicallyChainedTo gene,silencing of
R5919 T9837 T9836 _lexicallyChainedTo cell,trophoblast
R5920 T9870 T9869 _lexicallyChainedTo cells,population of
R5921 T9875 T9874 _lexicallyChainedTo cells,population of
R5922 T9884 T9883 _lexicallyChainedTo population,cellular
R5923 T9892 T9891 _lexicallyChainedTo differentiation,cell
R5924 T9904 T9903 _lexicallyChainedTo cells,population of
R5925 T9910 T9909 _lexicallyChainedTo paternal X,inactivation of
R5926 T9923 T9922 _lexicallyChainedTo Xp chromosome,inactivation of

2_test

Id Subject Object Predicate Lexical cue
16628246-1152998-85799773 365-367 1152998 denotes 18
16628246-12400016-85799774 1394-1396 12400016 denotes 29
16628246-12169625-85799774 1394-1396 12169625 denotes 29
16628246-15242790-85799774 1394-1396 15242790 denotes 29
16628246-14661031-85799775 2310-2312 14661031 denotes 32
16628246-7834909-85799776 3124-3126 7834909 denotes 33
16628246-10794075-85799777 3127-3129 10794075 denotes 34
16628246-11252054-85799778 3140-3142 11252054 denotes 35
16628246-1152998-85799779 3413-3415 1152998 denotes 18
16628246-958416-85799780 3416-3418 958416 denotes 36
16628246-11698184-85799781 3891-3893 11698184 denotes 37
16628246-11051544-85799782 4058-4060 11051544 denotes 38
16628246-9009199-85799783 4934-4936 9009199 denotes 39
T3361 365-367 1152998 denotes 18
T78774 1394-1396 12400016 denotes 29
T99673 1394-1396 12169625 denotes 29
T50636 1394-1396 15242790 denotes 29
T87099 2310-2312 14661031 denotes 32
T81121 3124-3126 7834909 denotes 33
T60587 3127-3129 10794075 denotes 34
T75568 3140-3142 11252054 denotes 35
T99758 3413-3415 1152998 denotes 18
T9314 3416-3418 958416 denotes 36
T45193 3891-3893 11698184 denotes 37
T45487 4058-4060 11051544 denotes 38
T9506 4934-4936 9009199 denotes 39

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9596 0-4 PR:000004503 denotes Atrx
T9597 13-37 GO:0060819 denotes Imprinted X-Inactivation
T9598 23-24 GO:0000805 denotes X
T9599 41-63 UBERON:0005292 denotes Extraembryonic Tissues
T9600 82-86 NCBITaxon:10088 denotes Mice
T9601 155-162 UBERON:0000922 denotes embryos
T9602 187-191 PR:000004503 denotes Atrx
T9603 195-201 SO:0001023 denotes allele
T9604 235-259 GO:0060819 denotes imprinted X-inactivation
T9605 245-246 GO:0000805 denotes X
T9606 278-286 GO:0016458 denotes silences
T9607 317-326 UBERON:0000922 denotes embryonic
T9608 349-355 NCBITaxon:39107 denotes murine
T9609 356-363 UBERON:0000479 denotes tissues
T9610 370-379 GO:0016458 denotes Silencing
T9611 387-391 PR:000004503 denotes Atrx
T9612 395-401 SO:0001023 denotes allele
T9613 445-449 PR:000004503 denotes Atrx
T9614 457-479 UBERON:0005292 denotes extraembryonic tissues
T9615 533-537 PR:000004503 denotes Atrx
T9616 546-552 SO:0001023 denotes allele
T9617 595-599 PR:000004503 denotes Atrx
T9618 649-658 GO:0000003 denotes reproduce
T9619 691-698 GO:0016458 denotes silence
T9620 722-726 PR:000007899 denotes Atrx
T9621 730-736 SO:0001023 denotes allele
T9622 744-766 UBERON:0005292 denotes extraembryonic tissues
T9623 830-834 PR:000007899 denotes Atrx
T9624 850-854 PR:000004503 denotes Atrx
T9625 913-924 UBERON:0000088 denotes trophoblast
T9626 971-976 NCBITaxon:10088 denotes mouse
T9627 994-998 PR:000004503 denotes Atrx
T9628 1084-1090 NCBITaxon:39107 denotes murine
T9629 1091-1092 GO:0000805 denotes X
T9630 1100-1105 SO:0000704 denotes genes
T9631 1140-1149 UBERON:0000922 denotes embryonic
T9632 1203-1211 PR:000006498 denotes dyskerin
T9633 1213-1217 PR:000006498 denotes Dkc1
T9634 1220-1239 CHEBI:14314 denotes glucose 6-phosphate
T9635 1266-1279 PR:000005430 denotes choroideremia
T9636 1281-1284 PR:000005430 denotes Chm
T9637 1286-1291 SO:0000704 denotes genes
T9638 1298-1307 UBERON:0000922 denotes embryonic
T9639 1331-1338 UBERON:0000922 denotes embryos
T9640 1367-1376 UBERON:0000922 denotes embryonic
T9641 1385-1392 UBERON:0000479 denotes tissues
T9642 1409-1413 NCBITaxon:10088 denotes mice
T9643 1442-1447 SO:0000704 denotes genes
T9644 1476-1488 GO:0000805 denotes X chromosome
T9645 1494-1497 GO:0016265 denotes die
T9646 1593-1597 PR:000004503 denotes Atrx
T9647 1605-1610 SO:0000704 denotes genes
T9648 1725-1747 UBERON:0005292 denotes extraembryonic tissues
T9649 1751-1758 GO:0010467 denotes express
T9650 1787-1799 GO:0000805 denotes X chromosome
T9651 1811-1821 GO:0010467 denotes expression
T9652 1838-1842 PR:000004503 denotes Atrx
T9653 1846-1852 SO:0001023 denotes allele
T9654 1874-1896 UBERON:0005292 denotes extraembryonic tissues
T9655 1904-1908 PR:000004503 denotes Atrx
T9656 1967-1968 GO:0000805 denotes X
T9657 1976-1981 SO:0000704 denotes genes
T9658 1983-1995 _FRAGMENT denotes silencing of
T9659 2005-2009 GO:0016458 denotes gene
T9660 2000-2004 PR:000004503 denotes Atrx
T9661 2005-2009 SO:0000704 denotes gene
T9662 2086-2090 PR:000004503 denotes Atrx
T9663 2136-2158 UBERON:0005292 denotes extraembryonic tissues
T9664 2216-2220 PR:000004503 denotes Atrx
T9665 2234-2240 SO:0001023 denotes allele
T9666 2255-2263 GO:0016458 denotes silenced
T9667 2276-2281 NCBITaxon:10088 denotes mouse
T9668 2282-2293 UBERON:0000088 denotes trophoblast
T9669 2282-2293 _FRAGMENT denotes trophoblast
T9670 2299-2303 CL:0000351 denotes cell
T9671 2294-2303 CL:0000034 denotes stem cell
T9672 2331-2335 PR:000004503 denotes Atrx
T9673 2361-2385 GO:0060819 denotes imprinted X-inactivation
T9674 2371-2372 GO:0000805 denotes X
T9675 2393-2415 UBERON:0005292 denotes extraembryonic tissues
T9676 2448-2458 GO:0010467 denotes expression
T9677 2476-2480 PR:000004503 denotes Atrx
T9678 2484-2490 SO:0001023 denotes allele
T9679 2544-2548 PR:000004503 denotes Atrx
T9680 2554-2560 SO:0001023 denotes allele
T9681 2669-2693 GO:0060819 denotes imprinted X-inactivation
T9682 2679-2680 GO:0000805 denotes X
T9683 2734-2739 NCBITaxon:10088 denotes mouse
T9684 2740-2762 UBERON:0005292 denotes extraembryonic tissues
T9685 2849-2861 GO:0000805 denotes X chromosome
T9686 3072-3082 GO:0010467 denotes expression
T9687 3109-3110 GO:0000805 denotes X
T9688 3118-3122 PR:000033987 denotes lacZ
T9689 3144-3154 SO:0000902 denotes transgenes
T9690 3168-3176 GO:0016458 denotes silenced
T9691 3205-3225 CL:0000349 denotes extraembryonic cells
T9692 3210-3219 UBERON:0000922 denotes embryonic
T9693 3281-3301 CL:0000349 denotes extraembryonic cells
T9694 3286-3295 UBERON:0000922 denotes embryonic
T9695 3355-3366 GO:0006260 denotes replication
T9696 3476-3483 UBERON:0000922 denotes embryos
T9697 3592-3601 GO:0071514 denotes imprinted
T9698 3616-3625 UBERON:0000922 denotes embryonic
T9699 3649-3658 GO:0016458 denotes silencing
T9700 3677-3681 _FRAGMENT denotes cell
T9701 3692-3707 GO:0030154 denotes differentiation
T9702 3801-3811 GO:0071514 denotes imprinting
T9703 3860-3871 SO:0000704 denotes genetically
T9704 3882-3889 UBERON:0000922 denotes embryos
T9705 3992-3999 SO:0001023 denotes alleles
T9706 4003-4008 SO:0000704 denotes genes
T9707 4035-4044 UBERON:0000922 denotes embryonic
T9708 4295-4299 PR:000004503 denotes Atrx
T9709 4336-4341 GO:0016265 denotes dying
T9710 4438-4453 _FRAGMENT denotes inactivation of
T9711 4458-4468 GO:0060817 denotes paternal X
T9712 4467-4468 GO:0000805 denotes X
T9713 4522-4526 PR:000004503 denotes Atrx
T9714 4527-4531 SO:0000704 denotes gene
T9715 4605-4609 PR:000004503 denotes Atrx
T9716 4624-4630 SO:0001023 denotes allele
T9717 4674-4683 GO:0016458 denotes silencing
T9718 4715-4720 SO:0000704 denotes genes
T9719 4737-4749 GO:0000805 denotes X chromosome
T9720 4800-4815 _FRAGMENT denotes inactivation of
T9721 4827-4840 GO:0060817 denotes Xp chromosome
T9722 4848-4857 UBERON:0000922 denotes embryonic
T9723 4877-4884 SO:0001023 denotes allelic
T9724 4885-4895 GO:0010467 denotes expression
T9725 4899-4900 GO:0000805 denotes X
T9726 4908-4913 SO:0000704 denotes genes
T9727 4921-4932 UBERON:0000088 denotes trophoblast
R5913 T9659 T9658 _lexicallyChainedTo gene,silencing of
R5914 T9670 T9669 _lexicallyChainedTo cell,trophoblast
R5915 T9701 T9700 _lexicallyChainedTo differentiation,cell
R5916 T9711 T9710 _lexicallyChainedTo paternal X,inactivation of
R5917 T9721 T9720 _lexicallyChainedTo Xp chromosome,inactivation of