Id |
Subject |
Object |
Predicate |
Lexical cue |
T9932 |
0-4 |
NN |
denotes |
Atrx |
T9933 |
5-12 |
VBZ |
denotes |
Escapes |
T9934 |
13-22 |
VBN |
denotes |
Imprinted |
T9935 |
25-37 |
NN |
denotes |
Inactivation |
T9936 |
23-24 |
NN |
denotes |
X |
T9937 |
24-25 |
HYPH |
denotes |
- |
T9938 |
38-40 |
IN |
denotes |
in |
T9939 |
41-55 |
JJ |
denotes |
Extraembryonic |
T9940 |
56-63 |
NNS |
denotes |
Tissues |
T9941 |
64-66 |
IN |
denotes |
of |
T9942 |
67-74 |
NN |
denotes |
Carrier |
T9943 |
82-86 |
NNS |
denotes |
Mice |
T9944 |
75-81 |
JJ |
denotes |
Female |
T9945 |
86-369 |
sentence |
denotes |
Another surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18]. |
T9946 |
87-94 |
DT |
denotes |
Another |
T9947 |
106-113 |
NN |
denotes |
finding |
T9948 |
95-105 |
JJ |
denotes |
surprising |
T9949 |
128-130 |
VBZ |
denotes |
is |
T9950 |
114-116 |
IN |
denotes |
of |
T9951 |
117-121 |
DT |
denotes |
this |
T9952 |
122-127 |
NN |
denotes |
study |
T9953 |
131-135 |
IN |
denotes |
that |
T9954 |
202-209 |
VBZ |
denotes |
appears |
T9955 |
135-137 |
, |
denotes |
, |
T9956 |
137-139 |
IN |
denotes |
in |
T9957 |
140-147 |
NN |
denotes |
carrier |
T9958 |
155-162 |
NNS |
denotes |
embryos |
T9959 |
148-154 |
JJ |
denotes |
female |
T9960 |
162-164 |
, |
denotes |
, |
T9961 |
164-165 |
DT |
denotes |
a |
T9962 |
195-201 |
NN |
denotes |
allele |
T9963 |
166-176 |
RB |
denotes |
paternally |
T9964 |
177-186 |
VBN |
denotes |
inherited |
T9965 |
187-194 |
NN |
denotes |
Atrx WT |
T9966 |
210-212 |
TO |
denotes |
to |
T9967 |
213-219 |
VB |
denotes |
escape |
T9968 |
220-223 |
DT |
denotes |
the |
T9969 |
224-231 |
NN |
denotes |
process |
T9970 |
232-234 |
IN |
denotes |
of |
T9971 |
235-244 |
VBN |
denotes |
imprinted |
T9972 |
247-259 |
NN |
denotes |
inactivation |
T9973 |
245-246 |
NN |
denotes |
X |
T9974 |
246-247 |
HYPH |
denotes |
- |
T9975 |
259-261 |
, |
denotes |
, |
T9976 |
261-266 |
WDT |
denotes |
which |
T9977 |
278-286 |
VBZ |
denotes |
silences |
T9978 |
267-277 |
RB |
denotes |
ordinarily |
T9979 |
287-290 |
DT |
denotes |
the |
T9980 |
294-304 |
NN |
denotes |
chromosome |
T9981 |
291-293 |
NN |
denotes |
Xp |
T9982 |
305-307 |
IN |
denotes |
in |
T9983 |
308-311 |
DT |
denotes |
the |
T9984 |
327-338 |
NN |
denotes |
compartment |
T9985 |
312-326 |
JJ |
denotes |
extraembryonic |
T9986 |
339-341 |
IN |
denotes |
of |
T9987 |
342-348 |
JJ |
denotes |
female |
T9988 |
356-363 |
NNS |
denotes |
tissues |
T9989 |
349-355 |
JJ |
denotes |
murine |
T9990 |
364-365 |
-LRB- |
denotes |
[ |
T9991 |
365-367 |
CD |
denotes |
18 |
T9992 |
367-368 |
-RRB- |
denotes |
] |
T9993 |
368-369 |
. |
denotes |
. |
T9994 |
369-553 |
sentence |
denotes |
Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele. |
T9995 |
370-379 |
NN |
denotes |
Silencing |
T9996 |
415-421 |
VB |
denotes |
render |
T9997 |
380-382 |
IN |
denotes |
of |
T9998 |
383-386 |
DT |
denotes |
the |
T9999 |
395-401 |
NN |
denotes |
allele |
T10000 |
387-394 |
NN |
denotes |
Atrx WT |
T10001 |
402-404 |
IN |
denotes |
on |
T10002 |
405-407 |
NN |
denotes |
Xp |
T10003 |
408-414 |
MD |
denotes |
should |
T10004 |
422-427 |
DT |
denotes |
these |
T10005 |
428-435 |
NNS |
denotes |
females |
T10006 |
436-440 |
JJ |
denotes |
null |
T10007 |
441-444 |
IN |
denotes |
for |
T10008 |
445-449 |
NN |
denotes |
Atrx |
T10009 |
450-452 |
IN |
denotes |
in |
T10010 |
453-456 |
DT |
denotes |
the |
T10011 |
472-479 |
NNS |
denotes |
tissues |
T10012 |
457-471 |
JJ |
denotes |
extraembryonic |
T10013 |
479-481 |
, |
denotes |
, |
T10014 |
481-486 |
IN |
denotes |
since |
T10015 |
521-528 |
VBZ |
denotes |
carries |
T10016 |
487-490 |
DT |
denotes |
the |
T10017 |
510-520 |
NN |
denotes |
chromosome |
T10018 |
491-499 |
RB |
denotes |
normally |
T10019 |
500-506 |
JJ |
denotes |
active |
T10020 |
507-509 |
NN |
denotes |
Xm |
T10021 |
529-532 |
DT |
denotes |
the |
T10022 |
546-552 |
NN |
denotes |
allele |
T10023 |
533-545 |
NN |
denotes |
Atrx Δ18Δneo |
T10024 |
552-553 |
. |
denotes |
. |
T10025 |
553-659 |
sentence |
denotes |
Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce. |
T10026 |
554-562 |
IN |
denotes |
Although |
T10027 |
582-588 |
JJ |
denotes |
normal |
T10028 |
563-566 |
RB |
denotes |
not |
T10029 |
567-581 |
RB |
denotes |
phenotypically |
T10030 |
616-625 |
VBD |
denotes |
developed |
T10031 |
588-590 |
, |
denotes |
, |
T10032 |
590-594 |
DT |
denotes |
some |
T10033 |
608-615 |
NNS |
denotes |
females |
T10034 |
595-599 |
NN |
denotes |
Atrx |
T10035 |
600-607 |
NN |
denotes |
carrier |
T10036 |
626-628 |
IN |
denotes |
to |
T10037 |
629-633 |
NN |
denotes |
term |
T10038 |
634-637 |
CC |
denotes |
and |
T10039 |
638-642 |
VBD |
denotes |
went |
T10040 |
643-645 |
RP |
denotes |
on |
T10041 |
646-648 |
TO |
denotes |
to |
T10042 |
649-658 |
VB |
denotes |
reproduce |
T10043 |
658-659 |
. |
denotes |
. |
T10044 |
659-977 |
sentence |
denotes |
Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse. |
T10045 |
660-664 |
RB |
denotes |
Thus |
T10046 |
786-788 |
VBZ |
denotes |
is |
T10047 |
664-666 |
, |
denotes |
, |
T10048 |
666-669 |
DT |
denotes |
the |
T10049 |
670-677 |
NN |
denotes |
failure |
T10050 |
678-680 |
TO |
denotes |
to |
T10051 |
691-698 |
VB |
denotes |
silence |
T10052 |
681-690 |
RB |
denotes |
correctly |
T10053 |
699-702 |
DT |
denotes |
the |
T10054 |
730-736 |
NN |
denotes |
allele |
T10146 |
1230-1239 |
NN |
denotes |
phosphate |
T10055 |
703-713 |
RB |
denotes |
paternally |
T10056 |
714-721 |
VBN |
denotes |
derived |
T10057 |
722-729 |
NN |
denotes |
Atrx WT |
T10058 |
737-739 |
IN |
denotes |
in |
T10059 |
740-743 |
DT |
denotes |
the |
T10060 |
759-766 |
NNS |
denotes |
tissues |
T10061 |
744-758 |
JJ |
denotes |
extraembryonic |
T10062 |
767-769 |
IN |
denotes |
of |
T10063 |
770-777 |
NN |
denotes |
carrier |
T10064 |
778-785 |
NNS |
denotes |
females |
T10065 |
789-799 |
JJ |
denotes |
consistent |
T10066 |
800-804 |
IN |
denotes |
with |
T10067 |
805-808 |
PRP$ |
denotes |
our |
T10068 |
809-821 |
NNS |
denotes |
observations |
T10069 |
822-826 |
IN |
denotes |
that |
T10070 |
863-868 |
VBZ |
denotes |
plays |
T10071 |
827-829 |
IN |
denotes |
in |
T10072 |
830-838 |
JJ |
denotes |
Atrxnull |
T10073 |
839-844 |
NNS |
denotes |
males |
T10074 |
844-846 |
, |
denotes |
, |
T10075 |
846-849 |
DT |
denotes |
the |
T10076 |
855-862 |
NN |
denotes |
protein |
T10077 |
850-854 |
NN |
denotes |
Atrx |
T10078 |
869-871 |
DT |
denotes |
an |
T10079 |
882-886 |
NN |
denotes |
role |
T10080 |
872-881 |
JJ |
denotes |
essential |
T10081 |
887-889 |
IN |
denotes |
in |
T10082 |
890-893 |
DT |
denotes |
the |
T10083 |
894-905 |
NN |
denotes |
development |
T10084 |
906-908 |
IN |
denotes |
of |
T10085 |
909-912 |
DT |
denotes |
the |
T10086 |
913-924 |
NN |
denotes |
trophoblast |
T10087 |
925-928 |
CC |
denotes |
and |
T10088 |
929-931 |
VBZ |
denotes |
is |
T10089 |
932-941 |
JJ |
denotes |
necessary |
T10090 |
942-945 |
IN |
denotes |
for |
T10091 |
946-954 |
NN |
denotes |
survival |
T10092 |
955-957 |
FW |
denotes |
in |
T10093 |
958-963 |
FW |
denotes |
utero |
T10094 |
964-966 |
IN |
denotes |
in |
T10095 |
967-970 |
DT |
denotes |
the |
T10096 |
971-976 |
NN |
denotes |
mouse |
T10097 |
976-977 |
. |
denotes |
. |
T10098 |
977-1162 |
sentence |
denotes |
The survival of Atrx carrier females contrasts with the phenotypes seen in carriers of mutations of other murine X-linked genes known to be essential in the extraembryonic compartment. |
T10099 |
978-981 |
DT |
denotes |
The |
T10100 |
982-990 |
NN |
denotes |
survival |
T10101 |
1015-1024 |
VBZ |
denotes |
contrasts |
T10102 |
991-993 |
IN |
denotes |
of |
T10103 |
994-998 |
NN |
denotes |
Atrx |
T10104 |
1007-1014 |
NNS |
denotes |
females |
T10105 |
999-1006 |
NN |
denotes |
carrier |
T10106 |
1025-1029 |
IN |
denotes |
with |
T10107 |
1030-1033 |
DT |
denotes |
the |
T10108 |
1034-1044 |
NNS |
denotes |
phenotypes |
T10109 |
1045-1049 |
VBN |
denotes |
seen |
T10110 |
1050-1052 |
IN |
denotes |
in |
T10111 |
1053-1061 |
NNS |
denotes |
carriers |
T10112 |
1062-1064 |
IN |
denotes |
of |
T10113 |
1065-1074 |
NNS |
denotes |
mutations |
T10114 |
1075-1077 |
IN |
denotes |
of |
T10115 |
1078-1083 |
JJ |
denotes |
other |
T10116 |
1100-1105 |
NNS |
denotes |
genes |
T10117 |
1084-1090 |
JJ |
denotes |
murine |
T10118 |
1091-1092 |
NN |
denotes |
X |
T10119 |
1093-1099 |
VBN |
denotes |
linked |
T10120 |
1092-1093 |
HYPH |
denotes |
- |
T10121 |
1106-1111 |
VBN |
denotes |
known |
T10122 |
1112-1114 |
TO |
denotes |
to |
T10123 |
1115-1117 |
VB |
denotes |
be |
T10124 |
1118-1127 |
JJ |
denotes |
essential |
T10125 |
1128-1130 |
IN |
denotes |
in |
T10126 |
1131-1134 |
DT |
denotes |
the |
T10127 |
1150-1161 |
NN |
denotes |
compartment |
T10128 |
1135-1149 |
JJ |
denotes |
extraembryonic |
T10129 |
1161-1162 |
. |
denotes |
. |
T10130 |
1162-1401 |
sentence |
denotes |
For example, targeted disruption of the dyskerin (Dkc1), glucose 6-phosphate dehydrogenase (G6PD), and choroideremia (Chm) genes cause embryonic lethality in null male embryos through defects of the extraembryonic-derived tissues [29–31]. |
T10131 |
1163-1166 |
IN |
denotes |
For |
T10132 |
1292-1297 |
VBP |
denotes |
cause |
T10133 |
1167-1174 |
NN |
denotes |
example |
T10134 |
1174-1176 |
, |
denotes |
, |
T10135 |
1176-1184 |
VBN |
denotes |
targeted |
T10136 |
1185-1195 |
NN |
denotes |
disruption |
T10137 |
1196-1198 |
IN |
denotes |
of |
T10138 |
1199-1202 |
DT |
denotes |
the |
T10139 |
1286-1291 |
NNS |
denotes |
genes |
T10140 |
1203-1211 |
NN |
denotes |
dyskerin |
T10141 |
1212-1213 |
-LRB- |
denotes |
( |
T10142 |
1213-1217 |
NN |
denotes |
Dkc1 |
T10143 |
1217-1218 |
-RRB- |
denotes |
) |
T10144 |
1218-1220 |
, |
denotes |
, |
T10145 |
1220-1227 |
NN |
denotes |
glucose |
T10147 |
1228-1229 |
CD |
denotes |
6 |
T10148 |
1229-1230 |
HYPH |
denotes |
- |
T10149 |
1240-1253 |
NN |
denotes |
dehydrogenase |
T10150 |
1254-1255 |
-LRB- |
denotes |
( |
T10151 |
1255-1259 |
NN |
denotes |
G6PD |
T10152 |
1259-1260 |
-RRB- |
denotes |
) |
T10153 |
1260-1262 |
, |
denotes |
, |
T10154 |
1262-1265 |
CC |
denotes |
and |
T10155 |
1266-1279 |
NN |
denotes |
choroideremia |
T10156 |
1280-1281 |
-LRB- |
denotes |
( |
T10157 |
1281-1284 |
NN |
denotes |
Chm |
T10158 |
1284-1285 |
-RRB- |
denotes |
) |
T10159 |
1298-1307 |
JJ |
denotes |
embryonic |
T10160 |
1308-1317 |
NN |
denotes |
lethality |
T10161 |
1318-1320 |
IN |
denotes |
in |
T10162 |
1321-1325 |
JJ |
denotes |
null |
T10163 |
1331-1338 |
NNS |
denotes |
embryos |
T10164 |
1326-1330 |
JJ |
denotes |
male |
T10165 |
1339-1346 |
IN |
denotes |
through |
T10166 |
1347-1354 |
NNS |
denotes |
defects |
T10167 |
1355-1357 |
IN |
denotes |
of |
T10168 |
1358-1361 |
DT |
denotes |
the |
T10169 |
1385-1392 |
NNS |
denotes |
tissues |
T10170 |
1362-1376 |
JJ |
denotes |
extraembryonic |
T10171 |
1377-1384 |
VBN |
denotes |
derived |
T10172 |
1376-1377 |
HYPH |
denotes |
- |
T10173 |
1393-1394 |
-LRB- |
denotes |
[ |
T10174 |
1394-1396 |
CD |
denotes |
29 |
T10175 |
1396-1397 |
SYM |
denotes |
– |
T10176 |
1397-1399 |
CD |
denotes |
31 |
T10177 |
1399-1400 |
-RRB- |
denotes |
] |
T10178 |
1400-1401 |
. |
denotes |
. |
T10179 |
1401-1579 |
sentence |
denotes |
Female mice carrying mutations of these genes on the maternally inherited X chromosome also die in utero, whereas females that inherit the mutation on the Xp chromosome survive. |
T10180 |
1402-1408 |
JJ |
denotes |
Female |
T10181 |
1409-1413 |
NNS |
denotes |
mice |
T10182 |
1494-1497 |
VBP |
denotes |
die |
T10183 |
1414-1422 |
VBG |
denotes |
carrying |
T10184 |
1423-1432 |
NNS |
denotes |
mutations |
T10185 |
1433-1435 |
IN |
denotes |
of |
T10186 |
1436-1441 |
DT |
denotes |
these |
T10187 |
1442-1447 |
NNS |
denotes |
genes |
T10188 |
1448-1450 |
IN |
denotes |
on |
T10189 |
1451-1454 |
DT |
denotes |
the |
T10190 |
1478-1488 |
NN |
denotes |
chromosome |
T10191 |
1455-1465 |
RB |
denotes |
maternally |
T10192 |
1466-1475 |
VBN |
denotes |
inherited |
T10193 |
1476-1477 |
NN |
denotes |
X |
T10194 |
1489-1493 |
RB |
denotes |
also |
T10195 |
1498-1500 |
FW |
denotes |
in |
T10196 |
1501-1506 |
FW |
denotes |
utero |
T10197 |
1506-1508 |
, |
denotes |
, |
T10198 |
1508-1515 |
IN |
denotes |
whereas |
T10199 |
1571-1578 |
VBP |
denotes |
survive |
T10200 |
1516-1523 |
NNS |
denotes |
females |
T10201 |
1524-1528 |
WDT |
denotes |
that |
T10202 |
1529-1536 |
VBP |
denotes |
inherit |
T10203 |
1537-1540 |
DT |
denotes |
the |
T10204 |
1541-1549 |
NN |
denotes |
mutation |
T10205 |
1550-1552 |
IN |
denotes |
on |
T10206 |
1553-1556 |
DT |
denotes |
the |
T10207 |
1560-1570 |
NN |
denotes |
chromosome |
T10208 |
1557-1559 |
NN |
denotes |
Xp |
T10209 |
1578-1579 |
. |
denotes |
. |
T10210 |
1579-1800 |
sentence |
denotes |
Thus, unlike Atrx, these genes and/or their effects on cell growth are unable to circumvent the processes that ultimately cause all cells in the extraembryonic tissues to express only the maternally derived X chromosome. |
T10211 |
1580-1584 |
RB |
denotes |
Thus |
T10212 |
1647-1650 |
VBP |
denotes |
are |
T10213 |
1584-1586 |
, |
denotes |
, |
T10214 |
1586-1592 |
IN |
denotes |
unlike |
T10215 |
1593-1597 |
NN |
denotes |
Atrx |
T10216 |
1597-1599 |
, |
denotes |
, |
T10217 |
1599-1604 |
DT |
denotes |
these |
T10218 |
1605-1610 |
NNS |
denotes |
genes |
T10219 |
1611-1614 |
CC |
denotes |
and |
T10220 |
1614-1615 |
HYPH |
denotes |
/ |
T10221 |
1615-1617 |
CC |
denotes |
or |
T10222 |
1618-1623 |
PRP$ |
denotes |
their |
T10223 |
1624-1631 |
NNS |
denotes |
effects |
T10224 |
1632-1634 |
IN |
denotes |
on |
T10225 |
1635-1639 |
NN |
denotes |
cell |
T10226 |
1640-1646 |
NN |
denotes |
growth |
T10227 |
1651-1657 |
JJ |
denotes |
unable |
T10228 |
1658-1660 |
TO |
denotes |
to |
T10229 |
1661-1671 |
VB |
denotes |
circumvent |
T10230 |
1672-1675 |
DT |
denotes |
the |
T10231 |
1676-1685 |
NNS |
denotes |
processes |
T10232 |
1686-1690 |
WDT |
denotes |
that |
T10233 |
1702-1707 |
VBP |
denotes |
cause |
T10234 |
1691-1701 |
RB |
denotes |
ultimately |
T10235 |
1708-1711 |
DT |
denotes |
all |
T10236 |
1712-1717 |
NNS |
denotes |
cells |
T10237 |
1751-1758 |
VB |
denotes |
express |
T10238 |
1718-1720 |
IN |
denotes |
in |
T10239 |
1721-1724 |
DT |
denotes |
the |
T10240 |
1740-1747 |
NNS |
denotes |
tissues |
T10241 |
1725-1739 |
JJ |
denotes |
extraembryonic |
T10242 |
1748-1750 |
TO |
denotes |
to |
T10243 |
1759-1763 |
RB |
denotes |
only |
T10244 |
1789-1799 |
NN |
denotes |
chromosome |
T10245 |
1764-1767 |
DT |
denotes |
the |
T10246 |
1768-1778 |
RB |
denotes |
maternally |
T10247 |
1779-1786 |
VBN |
denotes |
derived |
T10248 |
1787-1788 |
NN |
denotes |
X |
T10249 |
1799-1800 |
. |
denotes |
. |
T10250 |
1800-1925 |
sentence |
denotes |
How might expression of the paternal Atrx WT allele be maintained in the extraembryonic tissues of the Atrx carrier females? |
T10251 |
1801-1804 |
WRB |
denotes |
How |
T10252 |
1856-1866 |
VBN |
denotes |
maintained |
T10253 |
1805-1810 |
MD |
denotes |
might |
T10254 |
1811-1821 |
NN |
denotes |
expression |
T10255 |
1822-1824 |
IN |
denotes |
of |
T10256 |
1825-1828 |
DT |
denotes |
the |
T10257 |
1846-1852 |
NN |
denotes |
allele |
T10258 |
1829-1837 |
JJ |
denotes |
paternal |
T10259 |
1838-1845 |
NN |
denotes |
Atrx WT |
T10260 |
1853-1855 |
VB |
denotes |
be |
T10261 |
1867-1869 |
IN |
denotes |
in |
T10262 |
1870-1873 |
DT |
denotes |
the |
T10263 |
1889-1896 |
NNS |
denotes |
tissues |
T10264 |
1874-1888 |
JJ |
denotes |
extraembryonic |
T10265 |
1897-1899 |
IN |
denotes |
of |
T10266 |
1900-1903 |
DT |
denotes |
the |
T10267 |
1917-1924 |
NNS |
denotes |
females |
T10268 |
1904-1908 |
NN |
denotes |
Atrx |
T10269 |
1909-1916 |
NN |
denotes |
carrier |
T10270 |
1924-1925 |
. |
denotes |
? |
T10271 |
1925-2159 |
sentence |
denotes |
One possibility is that, like some other X-linked genes, silencing of the Atrx gene on Xp is incomplete, such that there is always a low-level, leaky output of Atrx from a normally inactivated Xp chromosome in extraembryonic tissues. |
T10272 |
1926-1929 |
CD |
denotes |
One |
T10273 |
1930-1941 |
NN |
denotes |
possibility |
T10274 |
1942-1944 |
VBZ |
denotes |
is |
T10275 |
1945-1949 |
IN |
denotes |
that |
T10276 |
2016-2018 |
VBZ |
denotes |
is |
T10277 |
1949-1951 |
, |
denotes |
, |
T10278 |
1951-1955 |
IN |
denotes |
like |
T10279 |
1956-1960 |
DT |
denotes |
some |
T10280 |
1976-1981 |
NNS |
denotes |
genes |
T10281 |
1961-1966 |
JJ |
denotes |
other |
T10282 |
1967-1968 |
NN |
denotes |
X |
T10283 |
1969-1975 |
JJ |
denotes |
linked |
T10284 |
1968-1969 |
HYPH |
denotes |
- |
T10285 |
1981-1983 |
, |
denotes |
, |
T10286 |
1983-1992 |
NN |
denotes |
silencing |
T10287 |
1993-1995 |
IN |
denotes |
of |
T10288 |
1996-1999 |
DT |
denotes |
the |
T10289 |
2005-2009 |
NN |
denotes |
gene |
T10290 |
2000-2004 |
NN |
denotes |
Atrx |
T10291 |
2010-2012 |
IN |
denotes |
on |
T10292 |
2013-2015 |
NN |
denotes |
Xp |
T10293 |
2019-2029 |
JJ |
denotes |
incomplete |
T10294 |
2029-2031 |
, |
denotes |
, |
T10295 |
2031-2035 |
JJ |
denotes |
such |
T10296 |
2047-2049 |
VBZ |
denotes |
is |
T10297 |
2036-2040 |
IN |
denotes |
that |
T10298 |
2041-2046 |
EX |
denotes |
there |
T10299 |
2050-2056 |
RB |
denotes |
always |
T10300 |
2057-2058 |
DT |
denotes |
a |
T10301 |
2076-2082 |
NN |
denotes |
output |
T10302 |
2059-2062 |
JJ |
denotes |
low |
T10303 |
2063-2068 |
NN |
denotes |
level |
T10304 |
2062-2063 |
HYPH |
denotes |
- |
T10305 |
2068-2070 |
, |
denotes |
, |
T10306 |
2070-2075 |
JJ |
denotes |
leaky |
T10307 |
2083-2085 |
IN |
denotes |
of |
T10308 |
2086-2090 |
NN |
denotes |
Atrx |
T10309 |
2091-2095 |
IN |
denotes |
from |
T10310 |
2096-2097 |
DT |
denotes |
a |
T10311 |
2122-2132 |
NN |
denotes |
chromosome |
T10312 |
2098-2106 |
RB |
denotes |
normally |
T10313 |
2107-2118 |
VBN |
denotes |
inactivated |
T10314 |
2119-2121 |
NN |
denotes |
Xp |
T10315 |
2133-2135 |
IN |
denotes |
in |
T10316 |
2136-2150 |
JJ |
denotes |
extraembryonic |
T10317 |
2151-2158 |
NNS |
denotes |
tissues |
T10318 |
2158-2159 |
. |
denotes |
. |
T10319 |
2159-2437 |
sentence |
denotes |
However, it was recently demonstrated that the paternal Atrx (called Xnp) allele is completely silenced in a normal mouse trophoblast stem cell line [32], suggesting that Atrx does not normally escape imprinted X-inactivation in the extraembryonic tissues of wild-type females. |
T10320 |
2160-2167 |
RB |
denotes |
However |
T10321 |
2185-2197 |
VBN |
denotes |
demonstrated |
T10322 |
2167-2169 |
, |
denotes |
, |
T10323 |
2169-2171 |
PRP |
denotes |
it |
T10324 |
2172-2175 |
VBD |
denotes |
was |
T10325 |
2176-2184 |
RB |
denotes |
recently |
T10326 |
2198-2202 |
IN |
denotes |
that |
T10327 |
2255-2263 |
VBN |
denotes |
silenced |
T10328 |
2203-2206 |
DT |
denotes |
the |
T10329 |
2234-2240 |
NN |
denotes |
allele |
T10330 |
2207-2215 |
JJ |
denotes |
paternal |
T10331 |
2216-2220 |
NN |
denotes |
Atrx |
T10332 |
2221-2222 |
-LRB- |
denotes |
( |
T10333 |
2222-2228 |
VBN |
denotes |
called |
T10334 |
2229-2232 |
NN |
denotes |
Xnp |
T10335 |
2232-2233 |
-RRB- |
denotes |
) |
T10336 |
2241-2243 |
VBZ |
denotes |
is |
T10337 |
2244-2254 |
RB |
denotes |
completely |
T10338 |
2264-2266 |
IN |
denotes |
in |
T10339 |
2267-2268 |
DT |
denotes |
a |
T10340 |
2304-2308 |
NN |
denotes |
line |
T10341 |
2269-2275 |
JJ |
denotes |
normal |
T10342 |
2276-2281 |
NN |
denotes |
mouse |
T10343 |
2282-2293 |
NN |
denotes |
trophoblast |
T10344 |
2294-2298 |
NN |
denotes |
stem |
T10345 |
2299-2303 |
NN |
denotes |
cell |
T10346 |
2309-2310 |
-LRB- |
denotes |
[ |
T10347 |
2310-2312 |
CD |
denotes |
32 |
T10348 |
2312-2313 |
-RRB- |
denotes |
] |
T10349 |
2313-2315 |
, |
denotes |
, |
T10350 |
2315-2325 |
VBG |
denotes |
suggesting |
T10351 |
2326-2330 |
IN |
denotes |
that |
T10352 |
2354-2360 |
VB |
denotes |
escape |
T10353 |
2331-2335 |
NN |
denotes |
Atrx |
T10354 |
2336-2340 |
VBZ |
denotes |
does |
T10355 |
2341-2344 |
RB |
denotes |
not |
T10356 |
2345-2353 |
RB |
denotes |
normally |
T10357 |
2361-2370 |
VBN |
denotes |
imprinted |
T10358 |
2373-2385 |
NN |
denotes |
inactivation |
T10359 |
2371-2372 |
NN |
denotes |
X |
T10360 |
2372-2373 |
HYPH |
denotes |
- |
T10361 |
2386-2388 |
IN |
denotes |
in |
T10362 |
2389-2392 |
DT |
denotes |
the |
T10363 |
2408-2415 |
NNS |
denotes |
tissues |
T10364 |
2393-2407 |
JJ |
denotes |
extraembryonic |
T10365 |
2416-2418 |
IN |
denotes |
of |
T10366 |
2419-2423 |
JJ |
denotes |
wild |
T10367 |
2424-2428 |
NN |
denotes |
type |
T10368 |
2423-2424 |
HYPH |
denotes |
- |
T10369 |
2429-2436 |
NNS |
denotes |
females |
T10370 |
2436-2437 |
. |
denotes |
. |
T10371 |
2437-2561 |
sentence |
denotes |
Thus, the expression of the Xp-linked Atrx WT allele that we observed is unique to female carriers of the Atrx null allele. |
T10372 |
2438-2442 |
RB |
denotes |
Thus |
T10373 |
2508-2510 |
VBZ |
denotes |
is |
T10374 |
2442-2444 |
, |
denotes |
, |
T10375 |
2444-2447 |
DT |
denotes |
the |
T10376 |
2448-2458 |
NN |
denotes |
expression |
T10377 |
2459-2461 |
IN |
denotes |
of |
T10378 |
2462-2465 |
DT |
denotes |
the |
T10379 |
2484-2490 |
NN |
denotes |
allele |
T10380 |
2466-2468 |
NN |
denotes |
Xp |
T10381 |
2469-2475 |
VBN |
denotes |
linked |
T10382 |
2468-2469 |
HYPH |
denotes |
- |
T10383 |
2476-2483 |
NN |
denotes |
Atrx WT |
T10384 |
2491-2495 |
WDT |
denotes |
that |
T10385 |
2499-2507 |
VBD |
denotes |
observed |
T10386 |
2496-2498 |
PRP |
denotes |
we |
T10387 |
2511-2517 |
JJ |
denotes |
unique |
T10388 |
2518-2520 |
IN |
denotes |
to |
T10389 |
2521-2527 |
JJ |
denotes |
female |
T10390 |
2528-2536 |
NNS |
denotes |
carriers |
T10391 |
2537-2539 |
IN |
denotes |
of |
T10392 |
2540-2543 |
DT |
denotes |
the |
T10393 |
2554-2560 |
NN |
denotes |
allele |
T10394 |
2544-2553 |
JJ |
denotes |
Atrx null |
T10395 |
2560-2561 |
. |
denotes |
. |
T10396 |
2561-2882 |
sentence |
denotes |
Perhaps a more likely explanation for this phenomenon stems from experimental observations suggesting that imprinted X-inactivation is not imposed on all precursors of the mouse extraembryonic tissues: A subpopulation of cells may escape this process and make a random “choice” of which X chromosome will be inactivated. |
T10397 |
2562-2569 |
RB |
denotes |
Perhaps |
T10398 |
2616-2621 |
VBZ |
denotes |
stems |
T10399 |
2570-2571 |
DT |
denotes |
a |
T10400 |
2584-2595 |
NN |
denotes |
explanation |
T10401 |
2572-2576 |
RBR |
denotes |
more |
T10402 |
2577-2583 |
JJ |
denotes |
likely |
T10403 |
2596-2599 |
IN |
denotes |
for |
T10404 |
2600-2604 |
DT |
denotes |
this |
T10405 |
2605-2615 |
NN |
denotes |
phenomenon |
T10406 |
2622-2626 |
IN |
denotes |
from |
T10407 |
2627-2639 |
JJ |
denotes |
experimental |
T10408 |
2640-2652 |
NNS |
denotes |
observations |
T10409 |
2653-2663 |
VBG |
denotes |
suggesting |
T10410 |
2664-2668 |
IN |
denotes |
that |
T10411 |
2793-2799 |
VB |
denotes |
escape |
T10412 |
2669-2678 |
VBN |
denotes |
imprinted |
T10413 |
2681-2693 |
NN |
denotes |
inactivation |
T10414 |
2679-2680 |
NN |
denotes |
X |
T10415 |
2680-2681 |
HYPH |
denotes |
- |
T10416 |
2701-2708 |
VBN |
denotes |
imposed |
T10417 |
2694-2696 |
VBZ |
denotes |
is |
T10418 |
2697-2700 |
RB |
denotes |
not |
T10419 |
2709-2711 |
IN |
denotes |
on |
T10420 |
2712-2715 |
DT |
denotes |
all |
T10421 |
2716-2726 |
NNS |
denotes |
precursors |
T10422 |
2727-2729 |
IN |
denotes |
of |
T10423 |
2730-2733 |
DT |
denotes |
the |
T10424 |
2755-2762 |
NNS |
denotes |
tissues |
T10425 |
2734-2739 |
NN |
denotes |
mouse |
T10426 |
2740-2754 |
JJ |
denotes |
extraembryonic |
T10427 |
2762-2764 |
: |
denotes |
: |
T10428 |
2764-2765 |
DT |
denotes |
A |
T10429 |
2766-2779 |
NN |
denotes |
subpopulation |
T10430 |
2780-2782 |
IN |
denotes |
of |
T10431 |
2783-2788 |
NNS |
denotes |
cells |
T10432 |
2789-2792 |
MD |
denotes |
may |
T10433 |
2800-2804 |
DT |
denotes |
this |
T10434 |
2805-2812 |
NN |
denotes |
process |
T10435 |
2813-2816 |
CC |
denotes |
and |
T10436 |
2817-2821 |
VB |
denotes |
make |
T10437 |
2822-2823 |
DT |
denotes |
a |
T10438 |
2832-2838 |
NN |
denotes |
choice |
T10439 |
2824-2830 |
JJ |
denotes |
random |
T10440 |
2831-2832 |
`` |
denotes |
“ |
T10441 |
2838-2839 |
'' |
denotes |
” |
T10442 |
2840-2842 |
IN |
denotes |
of |
T10443 |
2843-2848 |
WDT |
denotes |
which |
T10444 |
2851-2861 |
NN |
denotes |
chromosome |
T10445 |
2849-2850 |
NN |
denotes |
X |
T10446 |
2870-2881 |
VBN |
denotes |
inactivated |
T10447 |
2862-2866 |
MD |
denotes |
will |
T10448 |
2867-2869 |
VB |
denotes |
be |
T10449 |
2881-2882 |
. |
denotes |
. |
T10450 |
2882-3010 |
sentence |
denotes |
On average, 50% of the cells in this randomly inactivating subpopulation would be expected to maintain an active Xp chromosome. |
T10451 |
2883-2885 |
IN |
denotes |
On |
T10452 |
2965-2973 |
VBN |
denotes |
expected |
T10453 |
2886-2893 |
JJ |
denotes |
average |
T10454 |
2893-2895 |
, |
denotes |
, |
T10455 |
2895-2897 |
CD |
denotes |
50 |
T10456 |
2897-2898 |
NN |
denotes |
% |
T10457 |
2899-2901 |
IN |
denotes |
of |
T10458 |
2902-2905 |
DT |
denotes |
the |
T10459 |
2906-2911 |
NNS |
denotes |
cells |
T10460 |
2912-2914 |
IN |
denotes |
in |
T10461 |
2915-2919 |
DT |
denotes |
this |
T10462 |
2942-2955 |
NN |
denotes |
subpopulation |
T10463 |
2920-2928 |
RB |
denotes |
randomly |
T10464 |
2929-2941 |
VBG |
denotes |
inactivating |
T10465 |
2956-2961 |
MD |
denotes |
would |
T10466 |
2962-2964 |
VB |
denotes |
be |
T10467 |
2974-2976 |
TO |
denotes |
to |
T10468 |
2977-2985 |
VB |
denotes |
maintain |
T10469 |
2986-2988 |
DT |
denotes |
an |
T10470 |
2999-3009 |
NN |
denotes |
chromosome |
T10471 |
2989-2995 |
JJ |
denotes |
active |
T10472 |
2996-2998 |
NN |
denotes |
Xp |
T10473 |
3009-3010 |
. |
denotes |
. |
T10474 |
3010-3226 |
sentence |
denotes |
In support of this hypothesis, it has been demonstrated that expression of paternally transmitted X-linked lacZ [33,34] and GFP [35] transgenes failed to be silenced in a small subpopulation of extraembryonic cells. |
T10475 |
3011-3013 |
IN |
denotes |
In |
T10476 |
3054-3066 |
VBN |
denotes |
demonstrated |
T10477 |
3014-3021 |
NN |
denotes |
support |
T10478 |
3022-3024 |
IN |
denotes |
of |
T10479 |
3025-3029 |
DT |
denotes |
this |
T10480 |
3030-3040 |
NN |
denotes |
hypothesis |
T10481 |
3040-3042 |
, |
denotes |
, |
T10482 |
3042-3044 |
PRP |
denotes |
it |
T10483 |
3045-3048 |
VBZ |
denotes |
has |
T10484 |
3049-3053 |
VBN |
denotes |
been |
T10485 |
3067-3071 |
IN |
denotes |
that |
T10486 |
3155-3161 |
VBD |
denotes |
failed |
T10487 |
3072-3082 |
NN |
denotes |
expression |
T10488 |
3083-3085 |
IN |
denotes |
of |
T10489 |
3086-3096 |
RB |
denotes |
paternally |
T10490 |
3097-3108 |
VBN |
denotes |
transmitted |
T10491 |
3118-3122 |
NN |
denotes |
lacZ |
T10492 |
3109-3110 |
NN |
denotes |
X |
T10493 |
3111-3117 |
VBN |
denotes |
linked |
T10494 |
3110-3111 |
HYPH |
denotes |
- |
T10495 |
3144-3154 |
NNS |
denotes |
transgenes |
T10496 |
3123-3124 |
-LRB- |
denotes |
[ |
T10497 |
3127-3129 |
CD |
denotes |
34 |
T10498 |
3124-3126 |
CD |
denotes |
33 |
T10499 |
3126-3127 |
, |
denotes |
, |
T10500 |
3129-3130 |
-RRB- |
denotes |
] |
T10501 |
3131-3134 |
CC |
denotes |
and |
T10502 |
3135-3138 |
NN |
denotes |
GFP |
T10503 |
3139-3140 |
-LRB- |
denotes |
[ |
T10504 |
3140-3142 |
CD |
denotes |
35 |
T10505 |
3142-3143 |
-RRB- |
denotes |
] |
T10506 |
3162-3164 |
TO |
denotes |
to |
T10507 |
3168-3176 |
VBN |
denotes |
silenced |
T10508 |
3165-3167 |
VB |
denotes |
be |
T10509 |
3177-3179 |
IN |
denotes |
in |
T10510 |
3180-3181 |
DT |
denotes |
a |
T10511 |
3188-3201 |
NN |
denotes |
subpopulation |
T10512 |
3182-3187 |
JJ |
denotes |
small |
T10513 |
3202-3204 |
IN |
denotes |
of |
T10514 |
3205-3219 |
JJ |
denotes |
extraembryonic |
T10515 |
3220-3225 |
NNS |
denotes |
cells |
T10516 |
3225-3226 |
. |
denotes |
. |
T10517 |
3226-3420 |
sentence |
denotes |
Further, it has been shown that in a subpopulation of extraembryonic cells, it is the Xm rather than the Xp that undergoes late replication, a molecular correlate of the inactive state [18,36]. |
T10518 |
3227-3234 |
RB |
denotes |
Further |
T10519 |
3248-3253 |
VBN |
denotes |
shown |
T10520 |
3234-3236 |
, |
denotes |
, |
T10521 |
3236-3238 |
PRP |
denotes |
it |
T10522 |
3239-3242 |
VBZ |
denotes |
has |
T10523 |
3243-3247 |
VBN |
denotes |
been |
T10524 |
3254-3258 |
IN |
denotes |
that |
T10525 |
3306-3308 |
VBZ |
denotes |
is |
T10526 |
3259-3261 |
IN |
denotes |
in |
T10527 |
3262-3263 |
DT |
denotes |
a |
T10528 |
3264-3277 |
NN |
denotes |
subpopulation |
T10529 |
3278-3280 |
IN |
denotes |
of |
T10530 |
3281-3295 |
JJ |
denotes |
extraembryonic |
T10531 |
3296-3301 |
NNS |
denotes |
cells |
T10532 |
3301-3303 |
, |
denotes |
, |
T10533 |
3303-3305 |
PRP |
denotes |
it |
T10534 |
3309-3312 |
DT |
denotes |
the |
T10535 |
3313-3315 |
NN |
denotes |
Xm |
T10536 |
3316-3322 |
JJ |
denotes |
rather |
T10537 |
3323-3327 |
IN |
denotes |
than |
T10538 |
3328-3331 |
DT |
denotes |
the |
T10539 |
3332-3334 |
NN |
denotes |
Xp |
T10540 |
3335-3339 |
WDT |
denotes |
that |
T10541 |
3340-3349 |
VBZ |
denotes |
undergoes |
T10542 |
3350-3354 |
JJ |
denotes |
late |
T10543 |
3355-3366 |
NN |
denotes |
replication |
T10544 |
3366-3368 |
, |
denotes |
, |
T10545 |
3368-3369 |
DT |
denotes |
a |
T10546 |
3380-3389 |
NN |
denotes |
correlate |
T10547 |
3370-3379 |
JJ |
denotes |
molecular |
T10548 |
3390-3392 |
IN |
denotes |
of |
T10549 |
3393-3396 |
DT |
denotes |
the |
T10550 |
3406-3411 |
NN |
denotes |
state |
T10551 |
3397-3405 |
JJ |
denotes |
inactive |
T10552 |
3412-3413 |
-LRB- |
denotes |
[ |
T10553 |
3416-3418 |
CD |
denotes |
36 |
T10554 |
3413-3415 |
CD |
denotes |
18 |
T10555 |
3415-3416 |
, |
denotes |
, |
T10556 |
3418-3419 |
-RRB- |
denotes |
] |
T10557 |
3419-3420 |
. |
denotes |
. |
T10558 |
3420-3708 |
sentence |
denotes |
Although initially small and quickly diluted in normal embryos, the cellular subpopulation that inactivates the Xm chromosome could rapidly expand to replace the normally imprinted cells in extraembryonic lineages if the normal silencing of Xp compromises cell growth or differentiation. |
T10559 |
3421-3429 |
IN |
denotes |
Although |
T10560 |
3440-3445 |
JJ |
denotes |
small |
T10561 |
3430-3439 |
RB |
denotes |
initially |
T10562 |
3561-3567 |
VB |
denotes |
expand |
T10563 |
3446-3449 |
CC |
denotes |
and |
T10564 |
3450-3457 |
RB |
denotes |
quickly |
T10565 |
3458-3465 |
VBN |
denotes |
diluted |
T10566 |
3466-3468 |
IN |
denotes |
in |
T10567 |
3469-3475 |
JJ |
denotes |
normal |
T10568 |
3476-3483 |
NNS |
denotes |
embryos |
T10569 |
3483-3485 |
, |
denotes |
, |
T10570 |
3485-3488 |
DT |
denotes |
the |
T10571 |
3498-3511 |
NN |
denotes |
subpopulation |
T10572 |
3489-3497 |
JJ |
denotes |
cellular |
T10573 |
3512-3516 |
WDT |
denotes |
that |
T10574 |
3517-3528 |
VBZ |
denotes |
inactivates |
T10575 |
3529-3532 |
DT |
denotes |
the |
T10576 |
3536-3546 |
NN |
denotes |
chromosome |
T10577 |
3533-3535 |
NN |
denotes |
Xm |
T10578 |
3547-3552 |
MD |
denotes |
could |
T10579 |
3553-3560 |
RB |
denotes |
rapidly |
T10580 |
3568-3570 |
TO |
denotes |
to |
T10581 |
3571-3578 |
VB |
denotes |
replace |
T10582 |
3579-3582 |
DT |
denotes |
the |
T10583 |
3602-3607 |
NNS |
denotes |
cells |
T10584 |
3583-3591 |
RB |
denotes |
normally |
T10585 |
3592-3601 |
VBN |
denotes |
imprinted |
T10586 |
3608-3610 |
IN |
denotes |
in |
T10587 |
3611-3625 |
JJ |
denotes |
extraembryonic |
T10588 |
3626-3634 |
NNS |
denotes |
lineages |
T10589 |
3635-3637 |
IN |
denotes |
if |
T10590 |
3665-3676 |
VBZ |
denotes |
compromises |
T10591 |
3638-3641 |
DT |
denotes |
the |
T10592 |
3649-3658 |
NN |
denotes |
silencing |
T10593 |
3642-3648 |
JJ |
denotes |
normal |
T10594 |
3659-3661 |
IN |
denotes |
of |
T10595 |
3662-3664 |
NN |
denotes |
Xp |
T10596 |
3677-3681 |
NN |
denotes |
cell |
T10597 |
3682-3688 |
NN |
denotes |
growth |
T10598 |
3689-3691 |
CC |
denotes |
or |
T10599 |
3692-3707 |
NN |
denotes |
differentiation |
T10600 |
3707-3708 |
. |
denotes |
. |
T10601 |
3708-4062 |
sentence |
denotes |
Interestingly, it has been suggested that the size of the population that initially escapes imprinting may range widely (from 0% to 30%), even between genetically identical embryos [37], and this may account for the variable phenotype observed among females bearing Xm-linked mutant alleles of genes essential for normal extraembryonic development [38]. |
T10602 |
3709-3722 |
RB |
denotes |
Interestingly |
T10603 |
3736-3745 |
VBN |
denotes |
suggested |
T10604 |
3722-3724 |
, |
denotes |
, |
T10605 |
3724-3726 |
PRP |
denotes |
it |
T10606 |
3727-3730 |
VBZ |
denotes |
has |
T10607 |
3731-3735 |
VBN |
denotes |
been |
T10608 |
3746-3750 |
IN |
denotes |
that |
T10609 |
3816-3821 |
VB |
denotes |
range |
T10610 |
3751-3754 |
DT |
denotes |
the |
T10611 |
3755-3759 |
NN |
denotes |
size |
T10612 |
3760-3762 |
IN |
denotes |
of |
T10613 |
3763-3766 |
DT |
denotes |
the |
T10614 |
3767-3777 |
NN |
denotes |
population |
T10615 |
3778-3782 |
WDT |
denotes |
that |
T10616 |
3793-3800 |
VBZ |
denotes |
escapes |
T10617 |
3783-3792 |
RB |
denotes |
initially |
T10618 |
3801-3811 |
NN |
denotes |
imprinting |
T10619 |
3812-3815 |
MD |
denotes |
may |
T10620 |
3822-3828 |
RB |
denotes |
widely |
T10621 |
3829-3830 |
-LRB- |
denotes |
( |
T10622 |
3830-3834 |
IN |
denotes |
from |
T10623 |
3835-3836 |
CD |
denotes |
0 |
T10624 |
3836-3837 |
NN |
denotes |
% |
T10625 |
3838-3840 |
IN |
denotes |
to |
T10626 |
3841-3843 |
CD |
denotes |
30 |
T10627 |
3843-3844 |
NN |
denotes |
% |
T10628 |
3844-3845 |
-RRB- |
denotes |
) |
T10629 |
3845-3847 |
, |
denotes |
, |
T10630 |
3847-3851 |
RB |
denotes |
even |
T10631 |
3852-3859 |
IN |
denotes |
between |
T10632 |
3860-3871 |
RB |
denotes |
genetically |
T10633 |
3872-3881 |
JJ |
denotes |
identical |
T10634 |
3882-3889 |
NNS |
denotes |
embryos |
T10635 |
3890-3891 |
-LRB- |
denotes |
[ |
T10636 |
3891-3893 |
CD |
denotes |
37 |
T10637 |
3893-3894 |
-RRB- |
denotes |
] |
T10638 |
3894-3896 |
, |
denotes |
, |
T10639 |
3896-3899 |
CC |
denotes |
and |
T10640 |
3900-3904 |
DT |
denotes |
this |
T10641 |
3909-3916 |
VB |
denotes |
account |
T10642 |
3905-3908 |
MD |
denotes |
may |
T10643 |
3917-3920 |
IN |
denotes |
for |
T10644 |
3921-3924 |
DT |
denotes |
the |
T10645 |
3934-3943 |
NN |
denotes |
phenotype |
T10646 |
3925-3933 |
JJ |
denotes |
variable |
T10647 |
3944-3952 |
VBN |
denotes |
observed |
T10648 |
3953-3958 |
IN |
denotes |
among |
T10649 |
3959-3966 |
NNS |
denotes |
females |
T10650 |
3967-3974 |
VBG |
denotes |
bearing |
T10651 |
3975-3977 |
NN |
denotes |
Xm |
T10652 |
3978-3984 |
VBN |
denotes |
linked |
T10653 |
3977-3978 |
HYPH |
denotes |
- |
T10654 |
3992-3999 |
NNS |
denotes |
alleles |
T10655 |
3985-3991 |
NN |
denotes |
mutant |
T10656 |
4000-4002 |
IN |
denotes |
of |
T10657 |
4003-4008 |
NNS |
denotes |
genes |
T10658 |
4009-4018 |
JJ |
denotes |
essential |
T10659 |
4019-4022 |
IN |
denotes |
for |
T10660 |
4023-4029 |
JJ |
denotes |
normal |
T10661 |
4045-4056 |
NN |
denotes |
development |
T10662 |
4030-4044 |
JJ |
denotes |
extraembryonic |
T10663 |
4057-4058 |
-LRB- |
denotes |
[ |
T10664 |
4058-4060 |
CD |
denotes |
38 |
T10665 |
4060-4061 |
-RRB- |
denotes |
] |
T10666 |
4061-4062 |
. |
denotes |
. |
T10667 |
4062-4215 |
sentence |
denotes |
Put simply, carrier females bearing a small initial population of escaping cells would be more severely affected than those bearing a larger population. |
T10668 |
4063-4066 |
VBN |
denotes |
Put |
T10669 |
4150-4152 |
VB |
denotes |
be |
T10670 |
4067-4073 |
RB |
denotes |
simply |
T10671 |
4073-4075 |
, |
denotes |
, |
T10672 |
4075-4082 |
NN |
denotes |
carrier |
T10673 |
4083-4090 |
NNS |
denotes |
females |
T10674 |
4091-4098 |
VBG |
denotes |
bearing |
T10675 |
4099-4100 |
DT |
denotes |
a |
T10676 |
4115-4125 |
NN |
denotes |
population |
T10677 |
4101-4106 |
JJ |
denotes |
small |
T10678 |
4107-4114 |
JJ |
denotes |
initial |
T10679 |
4126-4128 |
IN |
denotes |
of |
T10680 |
4129-4137 |
VBG |
denotes |
escaping |
T10681 |
4138-4143 |
NNS |
denotes |
cells |
T10682 |
4144-4149 |
MD |
denotes |
would |
T10683 |
4153-4157 |
RBR |
denotes |
more |
T10684 |
4158-4166 |
RB |
denotes |
severely |
T10685 |
4167-4175 |
VBN |
denotes |
affected |
T10686 |
4176-4180 |
IN |
denotes |
than |
T10687 |
4181-4186 |
DT |
denotes |
those |
T10688 |
4187-4194 |
VBG |
denotes |
bearing |
T10689 |
4195-4196 |
DT |
denotes |
a |
T10690 |
4204-4214 |
NN |
denotes |
population |
T10691 |
4197-4203 |
JJR |
denotes |
larger |
T10692 |
4214-4215 |
. |
denotes |
. |
T10693 |
4215-4402 |
sentence |
denotes |
This could explain why we have observed significant phenotypic variation among Atrx carrier females, with some carriers dying in utero by 9.5 dpc (Table 1) and others developing to term. |
T10694 |
4216-4220 |
DT |
denotes |
This |
T10695 |
4227-4234 |
VB |
denotes |
explain |
T10696 |
4221-4226 |
MD |
denotes |
could |
T10697 |
4235-4238 |
WRB |
denotes |
why |
T10698 |
4247-4255 |
VBN |
denotes |
observed |
T10699 |
4239-4241 |
PRP |
denotes |
we |
T10700 |
4242-4246 |
VBP |
denotes |
have |
T10701 |
4256-4267 |
JJ |
denotes |
significant |
T10702 |
4279-4288 |
NN |
denotes |
variation |
T10703 |
4268-4278 |
JJ |
denotes |
phenotypic |
T10704 |
4289-4294 |
IN |
denotes |
among |
T10705 |
4295-4299 |
NN |
denotes |
Atrx |
T10706 |
4300-4307 |
NN |
denotes |
carrier |
T10707 |
4308-4315 |
NNS |
denotes |
females |
T10708 |
4315-4317 |
, |
denotes |
, |
T10709 |
4317-4321 |
IN |
denotes |
with |
T10710 |
4322-4326 |
DT |
denotes |
some |
T10711 |
4327-4335 |
NNS |
denotes |
carriers |
T10712 |
4336-4341 |
VBG |
denotes |
dying |
T10713 |
4342-4344 |
FW |
denotes |
in |
T10714 |
4345-4350 |
FW |
denotes |
utero |
T10715 |
4351-4353 |
IN |
denotes |
by |
T10716 |
4354-4357 |
CD |
denotes |
9.5 |
T10717 |
4358-4361 |
NNS |
denotes |
dpc |
T10718 |
4362-4363 |
-LRB- |
denotes |
( |
T10719 |
4363-4368 |
NN |
denotes |
Table |
T10720 |
4369-4370 |
CD |
denotes |
1 |
T10721 |
4370-4371 |
-RRB- |
denotes |
) |
T10722 |
4372-4375 |
CC |
denotes |
and |
T10723 |
4376-4382 |
NNS |
denotes |
others |
T10724 |
4383-4393 |
VBG |
denotes |
developing |
T10725 |
4394-4396 |
IN |
denotes |
to |
T10726 |
4397-4401 |
NN |
denotes |
term |
T10727 |
4401-4402 |
. |
denotes |
. |
T10728 |
4402-4571 |
sentence |
denotes |
Another possible mechanism is that inactivation of the paternal X proceeds normally in all cells, but subsequently the Atrx gene within individual cells is reactivated. |
T10729 |
4403-4410 |
DT |
denotes |
Another |
T10730 |
4420-4429 |
NN |
denotes |
mechanism |
T10731 |
4411-4419 |
JJ |
denotes |
possible |
T10732 |
4430-4432 |
VBZ |
denotes |
is |
T10733 |
4433-4437 |
IN |
denotes |
that |
T10734 |
4469-4477 |
VBZ |
denotes |
proceeds |
T10735 |
4438-4450 |
NN |
denotes |
inactivation |
T10736 |
4451-4453 |
IN |
denotes |
of |
T10737 |
4454-4457 |
DT |
denotes |
the |
T10738 |
4467-4468 |
NN |
denotes |
X |
T10739 |
4458-4466 |
JJ |
denotes |
paternal |
T10740 |
4478-4486 |
RB |
denotes |
normally |
T10741 |
4487-4489 |
IN |
denotes |
in |
T10742 |
4490-4493 |
DT |
denotes |
all |
T10743 |
4494-4499 |
NNS |
denotes |
cells |
T10744 |
4499-4501 |
, |
denotes |
, |
T10745 |
4501-4504 |
CC |
denotes |
but |
T10746 |
4505-4517 |
RB |
denotes |
subsequently |
T10747 |
4559-4570 |
VBN |
denotes |
reactivated |
T10748 |
4518-4521 |
DT |
denotes |
the |
T10749 |
4527-4531 |
NN |
denotes |
gene |
T10750 |
4522-4526 |
NN |
denotes |
Atrx |
T10751 |
4532-4538 |
IN |
denotes |
within |
T10752 |
4539-4549 |
JJ |
denotes |
individual |
T10753 |
4550-4555 |
NNS |
denotes |
cells |
T10754 |
4556-4558 |
VBZ |
denotes |
is |
T10755 |
4570-4571 |
. |
denotes |
. |
T10756 |
4571-4684 |
sentence |
denotes |
Alternatively, in the absence of Atrx, the paternal allele may partially escape the normal process of silencing. |
T10757 |
4572-4585 |
RB |
denotes |
Alternatively |
T10758 |
4645-4651 |
VB |
denotes |
escape |
T10759 |
4585-4587 |
, |
denotes |
, |
T10760 |
4587-4589 |
IN |
denotes |
in |
T10761 |
4590-4593 |
DT |
denotes |
the |
T10762 |
4594-4601 |
NN |
denotes |
absence |
T10763 |
4602-4604 |
IN |
denotes |
of |
T10764 |
4605-4609 |
NN |
denotes |
Atrx |
T10765 |
4609-4611 |
, |
denotes |
, |
T10766 |
4611-4614 |
DT |
denotes |
the |
T10767 |
4624-4630 |
NN |
denotes |
allele |
T10768 |
4615-4623 |
JJ |
denotes |
paternal |
T10769 |
4631-4634 |
MD |
denotes |
may |
T10770 |
4635-4644 |
RB |
denotes |
partially |
T10771 |
4652-4655 |
DT |
denotes |
the |
T10772 |
4663-4670 |
NN |
denotes |
process |
T10773 |
4656-4662 |
JJ |
denotes |
normal |
T10774 |
4671-4673 |
IN |
denotes |
of |
T10775 |
4674-4683 |
NN |
denotes |
silencing |
T10776 |
4683-4684 |
. |
denotes |
. |
T10777 |
4684-4938 |
sentence |
denotes |
In both of these cases, other genes on the paternal X chromosome must be inactivated and remain so, since blocking inactivation of the entire Xp chromosome causes embryonic lethality due to biallelic expression of X-linked genes in the trophoblast [39]. |
T10778 |
4685-4687 |
IN |
denotes |
In |
T10779 |
4758-4769 |
VBN |
denotes |
inactivated |
T10780 |
4688-4692 |
DT |
denotes |
both |
T10781 |
4693-4695 |
IN |
denotes |
of |
T10782 |
4696-4701 |
DT |
denotes |
these |
T10783 |
4702-4707 |
NNS |
denotes |
cases |
T10784 |
4707-4709 |
, |
denotes |
, |
T10785 |
4709-4714 |
JJ |
denotes |
other |
T10786 |
4715-4720 |
NNS |
denotes |
genes |
T10787 |
4721-4723 |
IN |
denotes |
on |
T10788 |
4724-4727 |
DT |
denotes |
the |
T10789 |
4739-4749 |
NN |
denotes |
chromosome |
T10790 |
4728-4736 |
JJ |
denotes |
paternal |
T10791 |
4737-4738 |
NN |
denotes |
X |
T10792 |
4750-4754 |
MD |
denotes |
must |
T10793 |
4755-4757 |
VB |
denotes |
be |
T10794 |
4770-4773 |
CC |
denotes |
and |
T10795 |
4774-4780 |
VBP |
denotes |
remain |
T10796 |
4781-4783 |
RB |
denotes |
so |
T10797 |
4783-4785 |
, |
denotes |
, |
T10798 |
4785-4790 |
IN |
denotes |
since |
T10799 |
4841-4847 |
VBZ |
denotes |
causes |
T10800 |
4791-4799 |
VBG |
denotes |
blocking |
T10801 |
4800-4812 |
NN |
denotes |
inactivation |
T10802 |
4813-4815 |
IN |
denotes |
of |
T10803 |
4816-4819 |
DT |
denotes |
the |
T10804 |
4830-4840 |
NN |
denotes |
chromosome |
T10805 |
4820-4826 |
JJ |
denotes |
entire |
T10806 |
4827-4829 |
NN |
denotes |
Xp |
T10807 |
4848-4857 |
JJ |
denotes |
embryonic |
T10808 |
4858-4867 |
NN |
denotes |
lethality |
T10809 |
4868-4871 |
IN |
denotes |
due |
T10810 |
4872-4874 |
IN |
denotes |
to |
T10811 |
4875-4884 |
JJ |
denotes |
biallelic |
T10812 |
4885-4895 |
NN |
denotes |
expression |
T10813 |
4896-4898 |
IN |
denotes |
of |
T10814 |
4899-4900 |
NN |
denotes |
X |
T10815 |
4901-4907 |
VBN |
denotes |
linked |
T10816 |
4900-4901 |
HYPH |
denotes |
- |
T10817 |
4908-4913 |
NNS |
denotes |
genes |
T10818 |
4914-4916 |
IN |
denotes |
in |
T10819 |
4917-4920 |
DT |
denotes |
the |
T10820 |
4921-4932 |
NN |
denotes |
trophoblast |
T10821 |
4933-4934 |
-LRB- |
denotes |
[ |
T10822 |
4934-4936 |
CD |
denotes |
39 |
T10823 |
4936-4937 |
-RRB- |
denotes |
] |
T10824 |
4937-4938 |
. |
denotes |
. |
R5927 |
T9932 |
T9933 |
nsubj |
Atrx,Escapes |
R5928 |
T9934 |
T9935 |
amod |
Imprinted,Inactivation |
R5929 |
T9935 |
T9933 |
dobj |
Inactivation,Escapes |
R5930 |
T9936 |
T9935 |
compound |
X,Inactivation |
R5931 |
T9937 |
T9935 |
punct |
-,Inactivation |
R5932 |
T9938 |
T9933 |
prep |
in,Escapes |
R5933 |
T9939 |
T9940 |
amod |
Extraembryonic,Tissues |
R5934 |
T9940 |
T9938 |
pobj |
Tissues,in |
R5935 |
T9941 |
T9940 |
prep |
of,Tissues |
R5936 |
T9942 |
T9943 |
nmod |
Carrier,Mice |
R5937 |
T9943 |
T9941 |
pobj |
Mice,of |
R5938 |
T9944 |
T9943 |
amod |
Female,Mice |
R5939 |
T9946 |
T9947 |
det |
Another,finding |
R5940 |
T9947 |
T9949 |
nsubj |
finding,is |
R5941 |
T9948 |
T9947 |
amod |
surprising,finding |
R5942 |
T9950 |
T9947 |
prep |
of,finding |
R5943 |
T9951 |
T9952 |
det |
this,study |
R5944 |
T9952 |
T9950 |
pobj |
study,of |
R5945 |
T9953 |
T9954 |
mark |
that,appears |
R5946 |
T9954 |
T9949 |
ccomp |
appears,is |
R5947 |
T9955 |
T9954 |
punct |
", ",appears |
R5948 |
T9956 |
T9954 |
prep |
in,appears |
R5949 |
T9957 |
T9958 |
nmod |
carrier,embryos |
R5950 |
T9958 |
T9956 |
pobj |
embryos,in |
R5951 |
T9959 |
T9958 |
amod |
female,embryos |
R5952 |
T9960 |
T9954 |
punct |
", ",appears |
R5953 |
T9961 |
T9962 |
det |
a,allele |
R5954 |
T9962 |
T9954 |
nsubj |
allele,appears |
R5955 |
T9963 |
T9964 |
advmod |
paternally,inherited |
R5956 |
T9964 |
T9962 |
amod |
inherited,allele |
R5957 |
T9965 |
T9962 |
compound |
Atrx WT,allele |
R5958 |
T9966 |
T9967 |
aux |
to,escape |
R5959 |
T9967 |
T9954 |
xcomp |
escape,appears |
R5960 |
T9968 |
T9969 |
det |
the,process |
R5961 |
T9969 |
T9967 |
dobj |
process,escape |
R5962 |
T9970 |
T9969 |
prep |
of,process |
R5963 |
T9971 |
T9972 |
amod |
imprinted,inactivation |
R5964 |
T9972 |
T9970 |
pobj |
inactivation,of |
R5965 |
T9973 |
T9972 |
compound |
X,inactivation |
R5966 |
T9974 |
T9972 |
punct |
-,inactivation |
R5967 |
T9975 |
T9969 |
punct |
", ",process |
R5968 |
T9976 |
T9977 |
dep |
which,silences |
R5969 |
T9977 |
T9969 |
relcl |
silences,process |
R5970 |
T9978 |
T9977 |
advmod |
ordinarily,silences |
R5971 |
T9979 |
T9980 |
det |
the,chromosome |
R5972 |
T9980 |
T9977 |
dobj |
chromosome,silences |
R5973 |
T9981 |
T9980 |
compound |
Xp,chromosome |
R5974 |
T9982 |
T9977 |
prep |
in,silences |
R5975 |
T9983 |
T9984 |
det |
the,compartment |
R5976 |
T9984 |
T9982 |
pobj |
compartment,in |
R5977 |
T9985 |
T9984 |
amod |
extraembryonic,compartment |
R5978 |
T9986 |
T9984 |
prep |
of,compartment |
R5979 |
T9987 |
T9988 |
amod |
female,tissues |
R5980 |
T9988 |
T9986 |
pobj |
tissues,of |
R5981 |
T9989 |
T9988 |
amod |
murine,tissues |
R5982 |
T9990 |
T9991 |
punct |
[,18 |
R5983 |
T9991 |
T9949 |
parataxis |
18,is |
R5984 |
T9992 |
T9991 |
punct |
],18 |
R5985 |
T9993 |
T9949 |
punct |
.,is |
R5986 |
T9995 |
T9996 |
nsubj |
Silencing,render |
R5987 |
T9997 |
T9995 |
prep |
of,Silencing |
R5988 |
T9998 |
T9999 |
det |
the,allele |
R5989 |
T9999 |
T9997 |
pobj |
allele,of |
R5990 |
T10000 |
T9999 |
compound |
Atrx WT,allele |
R5991 |
T10001 |
T9995 |
prep |
on,Silencing |
R5992 |
T10002 |
T10001 |
pobj |
Xp,on |
R5993 |
T10003 |
T9996 |
aux |
should,render |
R5994 |
T10004 |
T10005 |
det |
these,females |
R5995 |
T10005 |
T9996 |
dobj |
females,render |
R5996 |
T10006 |
T9996 |
oprd |
null,render |
R5997 |
T10007 |
T10006 |
prep |
for,null |
R5998 |
T10008 |
T10007 |
pobj |
Atrx,for |
R5999 |
T10009 |
T9996 |
prep |
in,render |
R6000 |
T10010 |
T10011 |
det |
the,tissues |
R6001 |
T10011 |
T10009 |
pobj |
tissues,in |
R6002 |
T10012 |
T10011 |
amod |
extraembryonic,tissues |
R6003 |
T10013 |
T9996 |
punct |
", ",render |
R6004 |
T10014 |
T10015 |
mark |
since,carries |
R6005 |
T10015 |
T9996 |
advcl |
carries,render |
R6006 |
T10016 |
T10017 |
det |
the,chromosome |
R6007 |
T10017 |
T10015 |
nsubj |
chromosome,carries |
R6008 |
T10018 |
T10019 |
advmod |
normally,active |
R6009 |
T10019 |
T10017 |
amod |
active,chromosome |
R6010 |
T10020 |
T10017 |
compound |
Xm,chromosome |
R6011 |
T10021 |
T10022 |
det |
the,allele |
R6012 |
T10022 |
T10015 |
dobj |
allele,carries |
R6013 |
T10023 |
T10022 |
compound |
Atrx Δ18Δneo,allele |
R6014 |
T10024 |
T9996 |
punct |
.,render |
R6015 |
T10026 |
T10027 |
mark |
Although,normal |
R6016 |
T10027 |
T10030 |
advcl |
normal,developed |
R6017 |
T10028 |
T10027 |
neg |
not,normal |
R6018 |
T10029 |
T10027 |
advmod |
phenotypically,normal |
R6019 |
T10031 |
T10030 |
punct |
", ",developed |
R6020 |
T10032 |
T10033 |
det |
some,females |
R6021 |
T10033 |
T10030 |
nsubj |
females,developed |
R6022 |
T10034 |
T10033 |
compound |
Atrx,females |
R6023 |
T10035 |
T10033 |
compound |
carrier,females |
R6024 |
T10036 |
T10030 |
prep |
to,developed |
R6025 |
T10037 |
T10036 |
pobj |
term,to |
R6026 |
T10038 |
T10030 |
cc |
and,developed |
R6027 |
T10039 |
T10030 |
conj |
went,developed |
R6028 |
T10040 |
T10039 |
prt |
on,went |
R6029 |
T10041 |
T10042 |
aux |
to,reproduce |
R6030 |
T10042 |
T10039 |
xcomp |
reproduce,went |
R6031 |
T10043 |
T10030 |
punct |
.,developed |
R6032 |
T10045 |
T10046 |
advmod |
Thus,is |
R6033 |
T10047 |
T10046 |
punct |
", ",is |
R6034 |
T10048 |
T10049 |
det |
the,failure |
R6035 |
T10049 |
T10046 |
nsubj |
failure,is |
R6036 |
T10050 |
T10051 |
aux |
to,silence |
R6037 |
T10051 |
T10049 |
acl |
silence,failure |
R6038 |
T10052 |
T10051 |
advmod |
correctly,silence |
R6039 |
T10053 |
T10054 |
det |
the,allele |
R6040 |
T10054 |
T10051 |
dobj |
allele,silence |
R6041 |
T10055 |
T10056 |
advmod |
paternally,derived |
R6042 |
T10056 |
T10054 |
amod |
derived,allele |
R6043 |
T10057 |
T10054 |
compound |
Atrx WT,allele |
R6044 |
T10058 |
T10054 |
prep |
in,allele |
R6045 |
T10059 |
T10060 |
det |
the,tissues |
R6046 |
T10060 |
T10058 |
pobj |
tissues,in |
R6047 |
T10061 |
T10060 |
amod |
extraembryonic,tissues |
R6048 |
T10062 |
T10060 |
prep |
of,tissues |
R6049 |
T10063 |
T10064 |
compound |
carrier,females |
R6050 |
T10064 |
T10062 |
pobj |
females,of |
R6051 |
T10065 |
T10046 |
acomp |
consistent,is |
R6052 |
T10066 |
T10065 |
prep |
with,consistent |
R6053 |
T10067 |
T10068 |
poss |
our,observations |
R6054 |
T10068 |
T10066 |
pobj |
observations,with |
R6055 |
T10069 |
T10070 |
mark |
that,plays |
R6056 |
T10070 |
T10068 |
acl |
plays,observations |
R6057 |
T10071 |
T10070 |
prep |
in,plays |
R6058 |
T10072 |
T10073 |
amod |
Atrxnull,males |
R6059 |
T10073 |
T10071 |
pobj |
males,in |
R6060 |
T10074 |
T10070 |
punct |
", ",plays |
R6061 |
T10075 |
T10076 |
det |
the,protein |
R6062 |
T10076 |
T10070 |
nsubj |
protein,plays |
R6063 |
T10077 |
T10076 |
compound |
Atrx,protein |
R6064 |
T10078 |
T10079 |
det |
an,role |
R6065 |
T10079 |
T10070 |
dobj |
role,plays |
R6066 |
T10080 |
T10079 |
amod |
essential,role |
R6067 |
T10081 |
T10070 |
prep |
in,plays |
R6068 |
T10082 |
T10083 |
det |
the,development |
R6069 |
T10083 |
T10081 |
pobj |
development,in |
R6070 |
T10084 |
T10083 |
prep |
of,development |
R6071 |
T10085 |
T10086 |
det |
the,trophoblast |
R6072 |
T10086 |
T10084 |
pobj |
trophoblast,of |
R6073 |
T10087 |
T10070 |
cc |
and,plays |
R6074 |
T10088 |
T10070 |
conj |
is,plays |
R6075 |
T10089 |
T10088 |
acomp |
necessary,is |
R6076 |
T10090 |
T10089 |
prep |
for,necessary |
R6077 |
T10091 |
T10090 |
pobj |
survival,for |
R6078 |
T10092 |
T10093 |
advmod |
in,utero |
R6079 |
T10093 |
T10091 |
advmod |
utero,survival |
R6080 |
T10094 |
T10088 |
prep |
in,is |
R6081 |
T10095 |
T10096 |
det |
the,mouse |
R6082 |
T10096 |
T10094 |
pobj |
mouse,in |
R6083 |
T10097 |
T10046 |
punct |
.,is |
R6084 |
T10099 |
T10100 |
det |
The,survival |
R6085 |
T10100 |
T10101 |
nsubj |
survival,contrasts |
R6086 |
T10102 |
T10100 |
prep |
of,survival |
R6087 |
T10103 |
T10104 |
compound |
Atrx,females |
R6088 |
T10104 |
T10102 |
pobj |
females,of |
R6089 |
T10105 |
T10104 |
compound |
carrier,females |
R6090 |
T10106 |
T10101 |
prep |
with,contrasts |
R6091 |
T10107 |
T10108 |
det |
the,phenotypes |
R6092 |
T10108 |
T10106 |
pobj |
phenotypes,with |
R6093 |
T10109 |
T10108 |
acl |
seen,phenotypes |
R6094 |
T10110 |
T10109 |
prep |
in,seen |
R6095 |
T10111 |
T10110 |
pobj |
carriers,in |
R6096 |
T10112 |
T10111 |
prep |
of,carriers |
R6097 |
T10113 |
T10112 |
pobj |
mutations,of |
R6098 |
T10114 |
T10113 |
prep |
of,mutations |
R6099 |
T10115 |
T10116 |
amod |
other,genes |
R6100 |
T10116 |
T10114 |
pobj |
genes,of |
R6101 |
T10117 |
T10116 |
amod |
murine,genes |
R6102 |
T10118 |
T10119 |
npadvmod |
X,linked |
R6103 |
T10119 |
T10116 |
amod |
linked,genes |
R6104 |
T10120 |
T10119 |
punct |
-,linked |
R6105 |
T10121 |
T10116 |
acl |
known,genes |
R6106 |
T10122 |
T10123 |
aux |
to,be |
R6107 |
T10123 |
T10121 |
xcomp |
be,known |
R6108 |
T10124 |
T10123 |
acomp |
essential,be |
R6109 |
T10125 |
T10123 |
prep |
in,be |
R6110 |
T10126 |
T10127 |
det |
the,compartment |
R6111 |
T10127 |
T10125 |
pobj |
compartment,in |
R6112 |
T10128 |
T10127 |
amod |
extraembryonic,compartment |
R6113 |
T10129 |
T10101 |
punct |
.,contrasts |
R6114 |
T10131 |
T10132 |
prep |
For,cause |
R6115 |
T10133 |
T10131 |
pobj |
example,For |
R6116 |
T10134 |
T10132 |
punct |
", ",cause |
R6117 |
T10135 |
T10136 |
amod |
targeted,disruption |
R6118 |
T10136 |
T10132 |
nsubj |
disruption,cause |
R6119 |
T10137 |
T10136 |
prep |
of,disruption |
R6120 |
T10138 |
T10139 |
det |
the,genes |
R6121 |
T10139 |
T10137 |
pobj |
genes,of |
R6122 |
T10140 |
T10139 |
nmod |
dyskerin,genes |
R6123 |
T10141 |
T10140 |
punct |
(,dyskerin |
R6124 |
T10142 |
T10140 |
appos |
Dkc1,dyskerin |
R6125 |
T10143 |
T10140 |
punct |
),dyskerin |
R6126 |
T10144 |
T10140 |
punct |
", ",dyskerin |
R6127 |
T10145 |
T10146 |
nmod |
glucose,phosphate |
R6128 |
T10146 |
T10149 |
compound |
phosphate,dehydrogenase |
R6129 |
T10147 |
T10146 |
nummod |
6,phosphate |
R6130 |
T10148 |
T10146 |
punct |
-,phosphate |
R6131 |
T10149 |
T10140 |
conj |
dehydrogenase,dyskerin |
R6132 |
T10150 |
T10149 |
punct |
(,dehydrogenase |
R6133 |
T10151 |
T10149 |
appos |
G6PD,dehydrogenase |
R6134 |
T10152 |
T10149 |
punct |
),dehydrogenase |
R6135 |
T10153 |
T10149 |
punct |
", ",dehydrogenase |
R6136 |
T10154 |
T10149 |
cc |
and,dehydrogenase |
R6137 |
T10155 |
T10149 |
conj |
choroideremia,dehydrogenase |
R6138 |
T10156 |
T10155 |
punct |
(,choroideremia |
R6139 |
T10157 |
T10155 |
appos |
Chm,choroideremia |
R6140 |
T10158 |
T10139 |
punct |
),genes |
R6141 |
T10159 |
T10160 |
amod |
embryonic,lethality |
R6142 |
T10160 |
T10132 |
dobj |
lethality,cause |
R6143 |
T10161 |
T10160 |
prep |
in,lethality |
R6144 |
T10162 |
T10163 |
amod |
null,embryos |
R6145 |
T10163 |
T10161 |
pobj |
embryos,in |
R6146 |
T10164 |
T10163 |
amod |
male,embryos |
R6147 |
T10165 |
T10132 |
prep |
through,cause |
R6148 |
T10166 |
T10165 |
pobj |
defects,through |
R6149 |
T10167 |
T10166 |
prep |
of,defects |
R6150 |
T10168 |
T10169 |
det |
the,tissues |
R6151 |
T10169 |
T10167 |
pobj |
tissues,of |
R6152 |
T10170 |
T10171 |
amod |
extraembryonic,derived |
R6153 |
T10171 |
T10169 |
amod |
derived,tissues |
R6154 |
T10172 |
T10171 |
punct |
-,derived |
R6155 |
T10173 |
T10174 |
punct |
[,29 |
R6156 |
T10174 |
T10132 |
parataxis |
29,cause |
R6157 |
T10175 |
T10176 |
punct |
–,31 |
R6158 |
T10176 |
T10174 |
prep |
31,29 |
R6159 |
T10177 |
T10174 |
punct |
],29 |
R6160 |
T10178 |
T10132 |
punct |
.,cause |
R6161 |
T10180 |
T10181 |
amod |
Female,mice |
R6162 |
T10181 |
T10182 |
nsubj |
mice,die |
R6163 |
T10183 |
T10181 |
acl |
carrying,mice |
R6164 |
T10184 |
T10183 |
dobj |
mutations,carrying |
R6165 |
T10185 |
T10184 |
prep |
of,mutations |
R6166 |
T10186 |
T10187 |
det |
these,genes |
R6167 |
T10187 |
T10185 |
pobj |
genes,of |
R6168 |
T10188 |
T10184 |
prep |
on,mutations |
R6169 |
T10189 |
T10190 |
det |
the,chromosome |
R6170 |
T10190 |
T10188 |
pobj |
chromosome,on |
R6171 |
T10191 |
T10192 |
advmod |
maternally,inherited |
R6172 |
T10192 |
T10190 |
amod |
inherited,chromosome |
R6173 |
T10193 |
T10190 |
compound |
X,chromosome |
R6174 |
T10194 |
T10182 |
advmod |
also,die |
R6175 |
T10195 |
T10196 |
advmod |
in,utero |
R6176 |
T10196 |
T10182 |
advmod |
utero,die |
R6177 |
T10197 |
T10182 |
punct |
", ",die |
R6178 |
T10198 |
T10199 |
mark |
whereas,survive |
R6179 |
T10199 |
T10182 |
advcl |
survive,die |
R6180 |
T10200 |
T10199 |
nsubj |
females,survive |
R6181 |
T10201 |
T10202 |
dep |
that,inherit |
R6182 |
T10202 |
T10200 |
relcl |
inherit,females |
R6183 |
T10203 |
T10204 |
det |
the,mutation |
R6184 |
T10204 |
T10202 |
dobj |
mutation,inherit |
R6185 |
T10205 |
T10204 |
prep |
on,mutation |
R6186 |
T10206 |
T10207 |
det |
the,chromosome |
R6187 |
T10207 |
T10205 |
pobj |
chromosome,on |
R6188 |
T10208 |
T10207 |
compound |
Xp,chromosome |
R6189 |
T10209 |
T10182 |
punct |
.,die |
R6190 |
T10211 |
T10212 |
advmod |
Thus,are |
R6191 |
T10213 |
T10212 |
punct |
", ",are |
R6192 |
T10214 |
T10212 |
prep |
unlike,are |
R6193 |
T10215 |
T10214 |
pobj |
Atrx,unlike |
R6194 |
T10216 |
T10212 |
punct |
", ",are |
R6195 |
T10217 |
T10218 |
det |
these,genes |
R6196 |
T10218 |
T10212 |
nsubj |
genes,are |
R6197 |
T10219 |
T10218 |
cc |
and,genes |
R6198 |
T10220 |
T10219 |
punct |
/,and |
R6199 |
T10221 |
T10219 |
cc |
or,and |
R6200 |
T10222 |
T10223 |
poss |
their,effects |
R6201 |
T10223 |
T10218 |
conj |
effects,genes |
R6202 |
T10224 |
T10223 |
prep |
on,effects |
R6203 |
T10225 |
T10226 |
compound |
cell,growth |
R6204 |
T10226 |
T10224 |
pobj |
growth,on |
R6205 |
T10227 |
T10212 |
acomp |
unable,are |
R6206 |
T10228 |
T10229 |
aux |
to,circumvent |
R6207 |
T10229 |
T10227 |
xcomp |
circumvent,unable |
R6208 |
T10230 |
T10231 |
det |
the,processes |
R6209 |
T10231 |
T10229 |
dobj |
processes,circumvent |
R6210 |
T10232 |
T10233 |
dep |
that,cause |
R6211 |
T10233 |
T10231 |
relcl |
cause,processes |
R6212 |
T10234 |
T10233 |
advmod |
ultimately,cause |
R6213 |
T10235 |
T10236 |
det |
all,cells |
R6214 |
T10236 |
T10237 |
nsubj |
cells,express |
R6215 |
T10237 |
T10233 |
ccomp |
express,cause |
R6216 |
T10238 |
T10236 |
prep |
in,cells |
R6217 |
T10239 |
T10240 |
det |
the,tissues |
R6218 |
T10240 |
T10238 |
pobj |
tissues,in |
R6219 |
T10241 |
T10240 |
amod |
extraembryonic,tissues |
R6220 |
T10242 |
T10237 |
aux |
to,express |
R6221 |
T10243 |
T10244 |
advmod |
only,chromosome |
R6222 |
T10244 |
T10237 |
dobj |
chromosome,express |
R6223 |
T10245 |
T10244 |
det |
the,chromosome |
R6224 |
T10246 |
T10247 |
advmod |
maternally,derived |
R6225 |
T10247 |
T10244 |
amod |
derived,chromosome |
R6226 |
T10248 |
T10244 |
compound |
X,chromosome |
R6227 |
T10249 |
T10212 |
punct |
.,are |
R6228 |
T10251 |
T10252 |
advmod |
How,maintained |
R6229 |
T10253 |
T10252 |
aux |
might,maintained |
R6230 |
T10254 |
T10252 |
nsubjpass |
expression,maintained |
R6231 |
T10255 |
T10254 |
prep |
of,expression |
R6232 |
T10256 |
T10257 |
det |
the,allele |
R6233 |
T10257 |
T10255 |
pobj |
allele,of |
R6234 |
T10258 |
T10259 |
amod |
paternal,Atrx WT |
R6235 |
T10259 |
T10257 |
compound |
Atrx WT,allele |
R6236 |
T10260 |
T10252 |
auxpass |
be,maintained |
R6237 |
T10261 |
T10252 |
prep |
in,maintained |
R6238 |
T10262 |
T10263 |
det |
the,tissues |
R6239 |
T10263 |
T10261 |
pobj |
tissues,in |
R6240 |
T10264 |
T10263 |
amod |
extraembryonic,tissues |
R6241 |
T10265 |
T10263 |
prep |
of,tissues |
R6242 |
T10266 |
T10267 |
det |
the,females |
R6243 |
T10267 |
T10265 |
pobj |
females,of |
R6244 |
T10268 |
T10269 |
compound |
Atrx,carrier |
R6245 |
T10269 |
T10267 |
compound |
carrier,females |
R6246 |
T10270 |
T10252 |
punct |
?,maintained |
R6247 |
T10272 |
T10273 |
nummod |
One,possibility |
R6248 |
T10273 |
T10274 |
nsubj |
possibility,is |
R6249 |
T10275 |
T10276 |
mark |
that,is |
R6250 |
T10276 |
T10274 |
ccomp |
is,is |
R6251 |
T10277 |
T10276 |
punct |
", ",is |
R6252 |
T10278 |
T10276 |
prep |
like,is |
R6253 |
T10279 |
T10280 |
det |
some,genes |
R6254 |
T10280 |
T10278 |
pobj |
genes,like |
R6255 |
T10281 |
T10280 |
amod |
other,genes |
R6256 |
T10282 |
T10283 |
npadvmod |
X,linked |
R6257 |
T10283 |
T10280 |
amod |
linked,genes |
R6258 |
T10284 |
T10283 |
punct |
-,linked |
R6259 |
T10285 |
T10276 |
punct |
", ",is |
R6260 |
T10286 |
T10276 |
nsubj |
silencing,is |
R6261 |
T10287 |
T10286 |
prep |
of,silencing |
R6262 |
T10288 |
T10289 |
det |
the,gene |
R6263 |
T10289 |
T10287 |
pobj |
gene,of |
R6264 |
T10290 |
T10289 |
compound |
Atrx,gene |
R6265 |
T10291 |
T10289 |
prep |
on,gene |
R6266 |
T10292 |
T10291 |
pobj |
Xp,on |
R6267 |
T10293 |
T10276 |
acomp |
incomplete,is |
R6268 |
T10294 |
T10276 |
punct |
", ",is |
R6269 |
T10295 |
T10296 |
amod |
such,is |
R6270 |
T10296 |
T10276 |
advcl |
is,is |
R6271 |
T10297 |
T10296 |
mark |
that,is |
R6272 |
T10298 |
T10296 |
expl |
there,is |
R6273 |
T10299 |
T10296 |
advmod |
always,is |
R6274 |
T10300 |
T10301 |
det |
a,output |
R6275 |
T10301 |
T10296 |
attr |
output,is |
R6276 |
T10302 |
T10303 |
amod |
low,level |
R6277 |
T10303 |
T10301 |
nmod |
level,output |
R6278 |
T10304 |
T10303 |
punct |
-,level |
R6279 |
T10305 |
T10301 |
punct |
", ",output |
R6280 |
T10306 |
T10301 |
amod |
leaky,output |
R6281 |
T10307 |
T10301 |
prep |
of,output |
R6282 |
T10308 |
T10307 |
pobj |
Atrx,of |
R6283 |
T10309 |
T10301 |
prep |
from,output |
R6284 |
T10310 |
T10311 |
det |
a,chromosome |
R6285 |
T10311 |
T10309 |
pobj |
chromosome,from |
R6286 |
T10312 |
T10313 |
advmod |
normally,inactivated |
R6287 |
T10313 |
T10311 |
amod |
inactivated,chromosome |
R6288 |
T10314 |
T10311 |
compound |
Xp,chromosome |
R6289 |
T10315 |
T10296 |
prep |
in,is |
R6290 |
T10316 |
T10317 |
amod |
extraembryonic,tissues |
R6291 |
T10317 |
T10315 |
pobj |
tissues,in |
R6292 |
T10318 |
T10274 |
punct |
.,is |
R6293 |
T10320 |
T10321 |
advmod |
However,demonstrated |
R6294 |
T10322 |
T10321 |
punct |
", ",demonstrated |
R6295 |
T10323 |
T10321 |
nsubjpass |
it,demonstrated |
R6296 |
T10324 |
T10321 |
auxpass |
was,demonstrated |
R6297 |
T10325 |
T10321 |
advmod |
recently,demonstrated |
R6298 |
T10326 |
T10327 |
mark |
that,silenced |
R6299 |
T10327 |
T10321 |
ccomp |
silenced,demonstrated |
R6300 |
T10328 |
T10329 |
det |
the,allele |
R6301 |
T10329 |
T10327 |
nsubjpass |
allele,silenced |
R6302 |
T10330 |
T10331 |
amod |
paternal,Atrx |
R6303 |
T10331 |
T10329 |
nmod |
Atrx,allele |
R6304 |
T10332 |
T10331 |
punct |
(,Atrx |
R6305 |
T10333 |
T10331 |
acl |
called,Atrx |
R6306 |
T10334 |
T10333 |
oprd |
Xnp,called |
R6307 |
T10335 |
T10329 |
punct |
),allele |
R6308 |
T10336 |
T10327 |
auxpass |
is,silenced |
R6309 |
T10337 |
T10327 |
advmod |
completely,silenced |
R6310 |
T10338 |
T10327 |
prep |
in,silenced |
R6311 |
T10339 |
T10340 |
det |
a,line |
R6312 |
T10340 |
T10338 |
pobj |
line,in |
R6313 |
T10341 |
T10340 |
amod |
normal,line |
R6314 |
T10342 |
T10343 |
compound |
mouse,trophoblast |
R6315 |
T10343 |
T10340 |
compound |
trophoblast,line |
R6316 |
T10344 |
T10345 |
compound |
stem,cell |
R6317 |
T10345 |
T10340 |
compound |
cell,line |
R6318 |
T10346 |
T10347 |
punct |
[,32 |
R6319 |
T10347 |
T10321 |
parataxis |
32,demonstrated |
R6320 |
T10348 |
T10347 |
punct |
],32 |
R6321 |
T10349 |
T10321 |
punct |
", ",demonstrated |
R6322 |
T10350 |
T10321 |
advcl |
suggesting,demonstrated |
R6323 |
T10351 |
T10352 |
mark |
that,escape |
R6324 |
T10352 |
T10350 |
ccomp |
escape,suggesting |
R6325 |
T10353 |
T10352 |
nsubj |
Atrx,escape |
R6326 |
T10354 |
T10352 |
aux |
does,escape |
R6327 |
T10355 |
T10352 |
neg |
not,escape |
R6328 |
T10356 |
T10352 |
advmod |
normally,escape |
R6329 |
T10357 |
T10358 |
amod |
imprinted,inactivation |
R6330 |
T10358 |
T10352 |
dobj |
inactivation,escape |
R6331 |
T10359 |
T10358 |
compound |
X,inactivation |
R6332 |
T10360 |
T10358 |
punct |
-,inactivation |
R6333 |
T10361 |
T10358 |
prep |
in,inactivation |
R6334 |
T10362 |
T10363 |
det |
the,tissues |
R6335 |
T10363 |
T10361 |
pobj |
tissues,in |
R6336 |
T10364 |
T10363 |
amod |
extraembryonic,tissues |
R6337 |
T10365 |
T10363 |
prep |
of,tissues |
R6338 |
T10366 |
T10367 |
amod |
wild,type |
R6339 |
T10367 |
T10369 |
compound |
type,females |
R6340 |
T10368 |
T10367 |
punct |
-,type |
R6341 |
T10369 |
T10365 |
pobj |
females,of |
R6342 |
T10370 |
T10321 |
punct |
.,demonstrated |
R6343 |
T10372 |
T10373 |
advmod |
Thus,is |
R6344 |
T10374 |
T10373 |
punct |
", ",is |
R6345 |
T10375 |
T10376 |
det |
the,expression |
R6346 |
T10376 |
T10373 |
nsubj |
expression,is |
R6347 |
T10377 |
T10376 |
prep |
of,expression |
R6348 |
T10378 |
T10379 |
det |
the,allele |
R6349 |
T10379 |
T10377 |
pobj |
allele,of |
R6350 |
T10380 |
T10381 |
npadvmod |
Xp,linked |
R6351 |
T10381 |
T10379 |
amod |
linked,allele |
R6352 |
T10382 |
T10381 |
punct |
-,linked |
R6353 |
T10383 |
T10379 |
compound |
Atrx WT,allele |
R6354 |
T10384 |
T10385 |
dep |
that,observed |
R6355 |
T10385 |
T10379 |
relcl |
observed,allele |
R6356 |
T10386 |
T10385 |
nsubj |
we,observed |
R6357 |
T10387 |
T10373 |
acomp |
unique,is |
R6358 |
T10388 |
T10387 |
prep |
to,unique |
R6359 |
T10389 |
T10390 |
amod |
female,carriers |
R6360 |
T10390 |
T10388 |
pobj |
carriers,to |
R6361 |
T10391 |
T10390 |
prep |
of,carriers |
R6362 |
T10392 |
T10393 |
det |
the,allele |
R6363 |
T10393 |
T10391 |
pobj |
allele,of |
R6364 |
T10394 |
T10393 |
amod |
Atrx null,allele |
R6365 |
T10395 |
T10373 |
punct |
.,is |
R6366 |
T10397 |
T10398 |
advmod |
Perhaps,stems |
R6367 |
T10399 |
T10400 |
det |
a,explanation |
R6368 |
T10400 |
T10398 |
nsubj |
explanation,stems |
R6369 |
T10401 |
T10402 |
advmod |
more,likely |
R6370 |
T10402 |
T10400 |
amod |
likely,explanation |
R6371 |
T10403 |
T10400 |
prep |
for,explanation |
R6372 |
T10404 |
T10405 |
det |
this,phenomenon |
R6373 |
T10405 |
T10403 |
pobj |
phenomenon,for |
R6374 |
T10406 |
T10398 |
prep |
from,stems |
R6375 |
T10407 |
T10408 |
amod |
experimental,observations |
R6376 |
T10408 |
T10406 |
pobj |
observations,from |
R6377 |
T10409 |
T10408 |
acl |
suggesting,observations |
R6378 |
T10410 |
T10411 |
mark |
that,escape |
R6379 |
T10411 |
T10409 |
ccomp |
escape,suggesting |
R6380 |
T10412 |
T10413 |
amod |
imprinted,inactivation |
R6381 |
T10413 |
T10416 |
nsubjpass |
inactivation,imposed |
R6382 |
T10414 |
T10413 |
compound |
X,inactivation |
R6383 |
T10415 |
T10413 |
punct |
-,inactivation |
R6384 |
T10416 |
T10411 |
ccomp |
imposed,escape |
R6385 |
T10417 |
T10416 |
auxpass |
is,imposed |
R6386 |
T10418 |
T10416 |
neg |
not,imposed |
R6387 |
T10419 |
T10416 |
prep |
on,imposed |
R6388 |
T10420 |
T10421 |
det |
all,precursors |
R6389 |
T10421 |
T10419 |
pobj |
precursors,on |
R6390 |
T10422 |
T10421 |
prep |
of,precursors |
R6391 |
T10423 |
T10424 |
det |
the,tissues |
R6392 |
T10424 |
T10422 |
pobj |
tissues,of |
R6393 |
T10425 |
T10424 |
nmod |
mouse,tissues |
R6394 |
T10426 |
T10425 |
amod |
extraembryonic,mouse |
R6395 |
T10427 |
T10411 |
punct |
: ,escape |
R6396 |
T10428 |
T10429 |
det |
A,subpopulation |
R6397 |
T10429 |
T10411 |
nsubj |
subpopulation,escape |
R6398 |
T10430 |
T10429 |
prep |
of,subpopulation |
R6399 |
T10431 |
T10430 |
pobj |
cells,of |
R6400 |
T10432 |
T10411 |
aux |
may,escape |
R6401 |
T10433 |
T10434 |
det |
this,process |
R6402 |
T10434 |
T10411 |
dobj |
process,escape |
R6403 |
T10435 |
T10411 |
cc |
and,escape |
R6404 |
T10436 |
T10411 |
conj |
make,escape |
R6405 |
T10437 |
T10438 |
det |
a,choice |
R6406 |
T10438 |
T10436 |
dobj |
choice,make |
R6407 |
T10439 |
T10438 |
amod |
random,choice |
R6408 |
T10440 |
T10438 |
punct |
“,choice |
R6409 |
T10441 |
T10438 |
punct |
”,choice |
R6410 |
T10442 |
T10438 |
prep |
of,choice |
R6411 |
T10443 |
T10444 |
det |
which,chromosome |
R6412 |
T10444 |
T10446 |
dep |
chromosome,inactivated |
R6413 |
T10445 |
T10444 |
compound |
X,chromosome |
R6414 |
T10446 |
T10442 |
pcomp |
inactivated,of |
R6415 |
T10447 |
T10446 |
aux |
will,inactivated |
R6416 |
T10448 |
T10446 |
auxpass |
be,inactivated |
R6417 |
T10449 |
T10398 |
punct |
.,stems |
R6418 |
T10451 |
T10452 |
prep |
On,expected |
R6419 |
T10453 |
T10451 |
amod |
average,On |
R6420 |
T10454 |
T10452 |
punct |
", ",expected |
R6421 |
T10455 |
T10456 |
nummod |
50,% |
R6422 |
T10456 |
T10452 |
nsubjpass |
%,expected |
R6423 |
T10457 |
T10456 |
prep |
of,% |
R6424 |
T10458 |
T10459 |
det |
the,cells |
R6425 |
T10459 |
T10457 |
pobj |
cells,of |
R6426 |
T10460 |
T10456 |
prep |
in,% |
R6427 |
T10461 |
T10462 |
det |
this,subpopulation |
R6428 |
T10462 |
T10460 |
pobj |
subpopulation,in |
R6429 |
T10463 |
T10464 |
advmod |
randomly,inactivating |
R6430 |
T10464 |
T10462 |
amod |
inactivating,subpopulation |
R6431 |
T10465 |
T10452 |
aux |
would,expected |
R6432 |
T10466 |
T10452 |
auxpass |
be,expected |
R6433 |
T10467 |
T10468 |
aux |
to,maintain |
R6434 |
T10468 |
T10452 |
xcomp |
maintain,expected |
R6435 |
T10469 |
T10470 |
det |
an,chromosome |
R6436 |
T10470 |
T10468 |
dobj |
chromosome,maintain |
R6437 |
T10471 |
T10470 |
amod |
active,chromosome |
R6438 |
T10472 |
T10470 |
compound |
Xp,chromosome |
R6439 |
T10473 |
T10452 |
punct |
.,expected |
R6440 |
T10475 |
T10476 |
prep |
In,demonstrated |
R6441 |
T10477 |
T10475 |
pobj |
support,In |
R6442 |
T10478 |
T10477 |
prep |
of,support |
R6443 |
T10479 |
T10480 |
det |
this,hypothesis |
R6444 |
T10480 |
T10478 |
pobj |
hypothesis,of |
R6445 |
T10481 |
T10476 |
punct |
", ",demonstrated |
R6446 |
T10482 |
T10476 |
nsubjpass |
it,demonstrated |
R6447 |
T10483 |
T10476 |
aux |
has,demonstrated |
R6448 |
T10484 |
T10476 |
auxpass |
been,demonstrated |
R6449 |
T10485 |
T10486 |
mark |
that,failed |
R6450 |
T10486 |
T10476 |
ccomp |
failed,demonstrated |
R6451 |
T10487 |
T10486 |
nsubj |
expression,failed |
R6452 |
T10488 |
T10487 |
prep |
of,expression |
R6453 |
T10489 |
T10490 |
advmod |
paternally,transmitted |
R6454 |
T10490 |
T10491 |
amod |
transmitted,lacZ |
R6455 |
T10491 |
T10495 |
nmod |
lacZ,transgenes |
R6456 |
T10492 |
T10493 |
npadvmod |
X,linked |
R6457 |
T10493 |
T10491 |
amod |
linked,lacZ |
R6458 |
T10494 |
T10493 |
punct |
-,linked |
R6459 |
T10495 |
T10488 |
pobj |
transgenes,of |
R6460 |
T10496 |
T10497 |
punct |
[,34 |
R6461 |
T10497 |
T10491 |
parataxis |
34,lacZ |
R6462 |
T10498 |
T10497 |
nummod |
33,34 |
R6463 |
T10499 |
T10497 |
punct |
",",34 |
R6464 |
T10500 |
T10497 |
punct |
],34 |
R6465 |
T10501 |
T10491 |
cc |
and,lacZ |
R6466 |
T10502 |
T10491 |
conj |
GFP,lacZ |
R6467 |
T10503 |
T10504 |
punct |
[,35 |
R6468 |
T10504 |
T10502 |
parataxis |
35,GFP |
R6469 |
T10505 |
T10504 |
punct |
],35 |
R6470 |
T10506 |
T10507 |
aux |
to,silenced |
R6471 |
T10507 |
T10486 |
xcomp |
silenced,failed |
R6472 |
T10508 |
T10507 |
auxpass |
be,silenced |
R6473 |
T10509 |
T10507 |
prep |
in,silenced |
R6474 |
T10510 |
T10511 |
det |
a,subpopulation |
R6475 |
T10511 |
T10509 |
pobj |
subpopulation,in |
R6476 |
T10512 |
T10511 |
amod |
small,subpopulation |
R6477 |
T10513 |
T10511 |
prep |
of,subpopulation |
R6478 |
T10514 |
T10515 |
amod |
extraembryonic,cells |
R6479 |
T10515 |
T10513 |
pobj |
cells,of |
R6480 |
T10516 |
T10476 |
punct |
.,demonstrated |
R6481 |
T10518 |
T10519 |
advmod |
Further,shown |
R6482 |
T10520 |
T10519 |
punct |
", ",shown |
R6483 |
T10521 |
T10519 |
nsubjpass |
it,shown |
R6484 |
T10522 |
T10519 |
aux |
has,shown |
R6485 |
T10523 |
T10519 |
auxpass |
been,shown |
R6486 |
T10524 |
T10525 |
mark |
that,is |
R6487 |
T10525 |
T10519 |
ccomp |
is,shown |
R6488 |
T10526 |
T10525 |
prep |
in,is |
R6489 |
T10527 |
T10528 |
det |
a,subpopulation |
R6490 |
T10528 |
T10526 |
pobj |
subpopulation,in |
R6491 |
T10529 |
T10528 |
prep |
of,subpopulation |
R6492 |
T10530 |
T10531 |
amod |
extraembryonic,cells |
R6493 |
T10531 |
T10529 |
pobj |
cells,of |
R6494 |
T10532 |
T10525 |
punct |
", ",is |
R6495 |
T10533 |
T10525 |
nsubj |
it,is |
R6496 |
T10534 |
T10535 |
det |
the,Xm |
R6497 |
T10535 |
T10525 |
attr |
Xm,is |
R6498 |
T10536 |
T10537 |
amod |
rather,than |
R6499 |
T10537 |
T10535 |
cc |
than,Xm |
R6500 |
T10538 |
T10539 |
det |
the,Xp |
R6501 |
T10539 |
T10535 |
conj |
Xp,Xm |
R6502 |
T10540 |
T10541 |
dep |
that,undergoes |
R6503 |
T10541 |
T10535 |
relcl |
undergoes,Xm |
R6504 |
T10542 |
T10543 |
amod |
late,replication |
R6505 |
T10543 |
T10541 |
dobj |
replication,undergoes |
R6506 |
T10544 |
T10543 |
punct |
", ",replication |
R6507 |
T10545 |
T10546 |
det |
a,correlate |
R6508 |
T10546 |
T10543 |
appos |
correlate,replication |
R6509 |
T10547 |
T10546 |
amod |
molecular,correlate |
R6510 |
T10548 |
T10546 |
prep |
of,correlate |
R6511 |
T10549 |
T10550 |
det |
the,state |
R6512 |
T10550 |
T10548 |
pobj |
state,of |
R6513 |
T10551 |
T10550 |
amod |
inactive,state |
R6514 |
T10552 |
T10553 |
punct |
[,36 |
R6515 |
T10553 |
T10525 |
parataxis |
36,is |
R6516 |
T10554 |
T10553 |
nummod |
18,36 |
R6517 |
T10555 |
T10553 |
punct |
",",36 |
R6518 |
T10556 |
T10553 |
punct |
],36 |
R6519 |
T10557 |
T10519 |
punct |
.,shown |
R6520 |
T10559 |
T10560 |
mark |
Although,small |
R6521 |
T10560 |
T10562 |
advcl |
small,expand |
R6522 |
T10561 |
T10560 |
advmod |
initially,small |
R6523 |
T10563 |
T10560 |
cc |
and,small |
R6524 |
T10564 |
T10565 |
advmod |
quickly,diluted |
R6525 |
T10565 |
T10560 |
conj |
diluted,small |
R6526 |
T10566 |
T10565 |
prep |
in,diluted |
R6527 |
T10567 |
T10568 |
amod |
normal,embryos |
R6528 |
T10568 |
T10566 |
pobj |
embryos,in |
R6529 |
T10569 |
T10562 |
punct |
", ",expand |
R6530 |
T10570 |
T10571 |
det |
the,subpopulation |
R6531 |
T10571 |
T10562 |
nsubj |
subpopulation,expand |
R6532 |
T10572 |
T10571 |
amod |
cellular,subpopulation |
R6533 |
T10573 |
T10574 |
dep |
that,inactivates |
R6534 |
T10574 |
T10571 |
relcl |
inactivates,subpopulation |
R6535 |
T10575 |
T10576 |
det |
the,chromosome |
R6536 |
T10576 |
T10574 |
dobj |
chromosome,inactivates |
R6537 |
T10577 |
T10576 |
compound |
Xm,chromosome |
R6538 |
T10578 |
T10562 |
aux |
could,expand |
R6539 |
T10579 |
T10562 |
advmod |
rapidly,expand |
R6540 |
T10580 |
T10581 |
aux |
to,replace |
R6541 |
T10581 |
T10562 |
advcl |
replace,expand |
R6542 |
T10582 |
T10583 |
det |
the,cells |
R6543 |
T10583 |
T10581 |
dobj |
cells,replace |
R6544 |
T10584 |
T10585 |
advmod |
normally,imprinted |
R6545 |
T10585 |
T10583 |
amod |
imprinted,cells |
R6546 |
T10586 |
T10583 |
prep |
in,cells |
R6547 |
T10587 |
T10588 |
amod |
extraembryonic,lineages |
R6548 |
T10588 |
T10586 |
pobj |
lineages,in |
R6549 |
T10589 |
T10590 |
mark |
if,compromises |
R6550 |
T10590 |
T10562 |
advcl |
compromises,expand |
R6551 |
T10591 |
T10592 |
det |
the,silencing |
R6552 |
T10592 |
T10590 |
nsubj |
silencing,compromises |
R6553 |
T10593 |
T10592 |
amod |
normal,silencing |
R6554 |
T10594 |
T10592 |
prep |
of,silencing |
R6555 |
T10595 |
T10594 |
pobj |
Xp,of |
R6556 |
T10596 |
T10597 |
compound |
cell,growth |
R6557 |
T10597 |
T10590 |
dobj |
growth,compromises |
R6558 |
T10598 |
T10597 |
cc |
or,growth |
R6559 |
T10599 |
T10597 |
conj |
differentiation,growth |
R6560 |
T10600 |
T10562 |
punct |
.,expand |
R6561 |
T10602 |
T10603 |
advmod |
Interestingly,suggested |
R6562 |
T10604 |
T10603 |
punct |
", ",suggested |
R6563 |
T10605 |
T10603 |
nsubjpass |
it,suggested |
R6564 |
T10606 |
T10603 |
aux |
has,suggested |
R6565 |
T10607 |
T10603 |
auxpass |
been,suggested |
R6566 |
T10608 |
T10609 |
mark |
that,range |
R6567 |
T10609 |
T10603 |
ccomp |
range,suggested |
R6568 |
T10610 |
T10611 |
det |
the,size |
R6569 |
T10611 |
T10609 |
nsubj |
size,range |
R6570 |
T10612 |
T10611 |
prep |
of,size |
R6571 |
T10613 |
T10614 |
det |
the,population |
R6572 |
T10614 |
T10612 |
pobj |
population,of |
R6573 |
T10615 |
T10616 |
dep |
that,escapes |
R6574 |
T10616 |
T10614 |
relcl |
escapes,population |
R6575 |
T10617 |
T10616 |
advmod |
initially,escapes |
R6576 |
T10618 |
T10616 |
dobj |
imprinting,escapes |
R6577 |
T10619 |
T10609 |
aux |
may,range |
R6578 |
T10620 |
T10609 |
advmod |
widely,range |
R6579 |
T10621 |
T10609 |
punct |
(,range |
R6580 |
T10622 |
T10609 |
prep |
from,range |
R6581 |
T10623 |
T10624 |
nummod |
0,% |
R6582 |
T10624 |
T10622 |
pobj |
%,from |
R6583 |
T10625 |
T10622 |
prep |
to,from |
R6584 |
T10626 |
T10627 |
nummod |
30,% |
R6585 |
T10627 |
T10625 |
pobj |
%,to |
R6586 |
T10628 |
T10609 |
punct |
),range |
R6587 |
T10629 |
T10609 |
punct |
", ",range |
R6588 |
T10630 |
T10631 |
advmod |
even,between |
R6589 |
T10631 |
T10609 |
prep |
between,range |
R6590 |
T10632 |
T10633 |
advmod |
genetically,identical |
R6591 |
T10633 |
T10634 |
amod |
identical,embryos |
R6592 |
T10634 |
T10631 |
pobj |
embryos,between |
R6593 |
T10635 |
T10636 |
punct |
[,37 |
R6594 |
T10636 |
T10609 |
parataxis |
37,range |
R6595 |
T10637 |
T10636 |
punct |
],37 |
R6596 |
T10638 |
T10603 |
punct |
", ",suggested |
R6597 |
T10639 |
T10603 |
cc |
and,suggested |
R6598 |
T10640 |
T10641 |
nsubj |
this,account |
R6599 |
T10641 |
T10603 |
conj |
account,suggested |
R6600 |
T10642 |
T10641 |
aux |
may,account |
R6601 |
T10643 |
T10641 |
prep |
for,account |
R6602 |
T10644 |
T10645 |
det |
the,phenotype |
R6603 |
T10645 |
T10643 |
pobj |
phenotype,for |
R6604 |
T10646 |
T10645 |
amod |
variable,phenotype |
R6605 |
T10647 |
T10645 |
acl |
observed,phenotype |
R6606 |
T10648 |
T10647 |
prep |
among,observed |
R6607 |
T10649 |
T10648 |
pobj |
females,among |
R6608 |
T10650 |
T10649 |
acl |
bearing,females |
R6609 |
T10651 |
T10652 |
npadvmod |
Xm,linked |
R6610 |
T10652 |
T10654 |
amod |
linked,alleles |
R6611 |
T10653 |
T10652 |
punct |
-,linked |
R6612 |
T10654 |
T10650 |
dobj |
alleles,bearing |
R6613 |
T10655 |
T10654 |
compound |
mutant,alleles |
R6614 |
T10656 |
T10654 |
prep |
of,alleles |
R6615 |
T10657 |
T10656 |
pobj |
genes,of |
R6616 |
T10658 |
T10657 |
amod |
essential,genes |
R6617 |
T10659 |
T10658 |
prep |
for,essential |
R6618 |
T10660 |
T10661 |
amod |
normal,development |
R6619 |
T10661 |
T10659 |
pobj |
development,for |
R6620 |
T10662 |
T10661 |
amod |
extraembryonic,development |
R6621 |
T10663 |
T10664 |
punct |
[,38 |
R6622 |
T10664 |
T10641 |
parataxis |
38,account |
R6623 |
T10665 |
T10664 |
punct |
],38 |
R6624 |
T10666 |
T10641 |
punct |
.,account |
R6625 |
T10668 |
T10669 |
advcl |
Put,be |
R6626 |
T10670 |
T10668 |
advmod |
simply,Put |
R6627 |
T10671 |
T10669 |
punct |
", ",be |
R6628 |
T10672 |
T10673 |
compound |
carrier,females |
R6629 |
T10673 |
T10669 |
nsubj |
females,be |
R6630 |
T10674 |
T10673 |
acl |
bearing,females |
R6631 |
T10675 |
T10676 |
det |
a,population |
R6632 |
T10676 |
T10674 |
dobj |
population,bearing |
R6633 |
T10677 |
T10676 |
amod |
small,population |
R6634 |
T10678 |
T10676 |
amod |
initial,population |
R6635 |
T10679 |
T10676 |
prep |
of,population |
R6636 |
T10680 |
T10681 |
amod |
escaping,cells |
R6637 |
T10681 |
T10679 |
pobj |
cells,of |
R6638 |
T10682 |
T10669 |
aux |
would,be |
R6639 |
T10683 |
T10684 |
advmod |
more,severely |
R6640 |
T10684 |
T10685 |
advmod |
severely,affected |
R6641 |
T10685 |
T10669 |
acomp |
affected,be |
R6642 |
T10686 |
T10685 |
prep |
than,affected |
R6643 |
T10687 |
T10686 |
pobj |
those,than |
R6644 |
T10688 |
T10687 |
acl |
bearing,those |
R6645 |
T10689 |
T10690 |
det |
a,population |
R6646 |
T10690 |
T10688 |
dobj |
population,bearing |
R6647 |
T10691 |
T10690 |
amod |
larger,population |
R6648 |
T10692 |
T10669 |
punct |
.,be |
R6649 |
T10694 |
T10695 |
nsubj |
This,explain |
R6650 |
T10696 |
T10695 |
aux |
could,explain |
R6651 |
T10697 |
T10698 |
advmod |
why,observed |
R6652 |
T10698 |
T10695 |
ccomp |
observed,explain |
R6653 |
T10699 |
T10698 |
nsubj |
we,observed |
R6654 |
T10700 |
T10698 |
aux |
have,observed |
R6655 |
T10701 |
T10702 |
amod |
significant,variation |
R6656 |
T10702 |
T10698 |
dobj |
variation,observed |
R6657 |
T10703 |
T10702 |
amod |
phenotypic,variation |
R6658 |
T10704 |
T10702 |
prep |
among,variation |
R6659 |
T10705 |
T10706 |
compound |
Atrx,carrier |
R6660 |
T10706 |
T10707 |
compound |
carrier,females |
R6661 |
T10707 |
T10704 |
pobj |
females,among |
R6662 |
T10708 |
T10698 |
punct |
", ",observed |
R6663 |
T10709 |
T10698 |
prep |
with,observed |
R6664 |
T10710 |
T10711 |
det |
some,carriers |
R6665 |
T10711 |
T10712 |
nsubj |
carriers,dying |
R6666 |
T10712 |
T10709 |
pobj |
dying,with |
R6667 |
T10713 |
T10714 |
advmod |
in,utero |
R6668 |
T10714 |
T10712 |
advmod |
utero,dying |
R6669 |
T10715 |
T10712 |
prep |
by,dying |
R6670 |
T10716 |
T10717 |
nummod |
9.5,dpc |
R6671 |
T10717 |
T10715 |
pobj |
dpc,by |
R6672 |
T10718 |
T10719 |
punct |
(,Table |
R6673 |
T10719 |
T10712 |
parataxis |
Table,dying |
R6674 |
T10720 |
T10719 |
nummod |
1,Table |
R6675 |
T10721 |
T10719 |
punct |
),Table |
R6676 |
T10722 |
T10712 |
cc |
and,dying |
R6677 |
T10723 |
T10724 |
nsubj |
others,developing |
R6678 |
T10724 |
T10712 |
conj |
developing,dying |
R6679 |
T10725 |
T10724 |
prep |
to,developing |
R6680 |
T10726 |
T10725 |
pobj |
term,to |
R6681 |
T10727 |
T10695 |
punct |
.,explain |
R6682 |
T10729 |
T10730 |
det |
Another,mechanism |
R6683 |
T10730 |
T10732 |
nsubj |
mechanism,is |
R6684 |
T10731 |
T10730 |
amod |
possible,mechanism |
R6685 |
T10733 |
T10734 |
mark |
that,proceeds |
R6686 |
T10734 |
T10732 |
ccomp |
proceeds,is |
R6687 |
T10735 |
T10734 |
nsubj |
inactivation,proceeds |
R6688 |
T10736 |
T10735 |
prep |
of,inactivation |
R6689 |
T10737 |
T10738 |
det |
the,X |
R6690 |
T10738 |
T10736 |
pobj |
X,of |
R6691 |
T10739 |
T10738 |
amod |
paternal,X |
R6692 |
T10740 |
T10734 |
advmod |
normally,proceeds |
R6693 |
T10741 |
T10734 |
prep |
in,proceeds |
R6694 |
T10742 |
T10743 |
det |
all,cells |
R6695 |
T10743 |
T10741 |
pobj |
cells,in |
R6696 |
T10744 |
T10734 |
punct |
", ",proceeds |
R6697 |
T10745 |
T10734 |
cc |
but,proceeds |
R6698 |
T10746 |
T10747 |
advmod |
subsequently,reactivated |
R6699 |
T10747 |
T10734 |
conj |
reactivated,proceeds |
R6700 |
T10748 |
T10749 |
det |
the,gene |
R6701 |
T10749 |
T10747 |
nsubjpass |
gene,reactivated |
R6702 |
T10750 |
T10749 |
compound |
Atrx,gene |
R6703 |
T10751 |
T10749 |
prep |
within,gene |
R6704 |
T10752 |
T10753 |
amod |
individual,cells |
R6705 |
T10753 |
T10751 |
pobj |
cells,within |
R6706 |
T10754 |
T10747 |
auxpass |
is,reactivated |
R6707 |
T10755 |
T10732 |
punct |
.,is |
R6708 |
T10757 |
T10758 |
advmod |
Alternatively,escape |
R6709 |
T10759 |
T10758 |
punct |
", ",escape |
R6710 |
T10760 |
T10758 |
prep |
in,escape |
R6711 |
T10761 |
T10762 |
det |
the,absence |
R6712 |
T10762 |
T10760 |
pobj |
absence,in |
R6713 |
T10763 |
T10762 |
prep |
of,absence |
R6714 |
T10764 |
T10763 |
pobj |
Atrx,of |
R6715 |
T10765 |
T10758 |
punct |
", ",escape |
R6716 |
T10766 |
T10767 |
det |
the,allele |
R6717 |
T10767 |
T10758 |
nsubj |
allele,escape |
R6718 |
T10768 |
T10767 |
amod |
paternal,allele |
R6719 |
T10769 |
T10758 |
aux |
may,escape |
R6720 |
T10770 |
T10758 |
advmod |
partially,escape |
R6721 |
T10771 |
T10772 |
det |
the,process |
R6722 |
T10772 |
T10758 |
dobj |
process,escape |
R6723 |
T10773 |
T10772 |
amod |
normal,process |
R6724 |
T10774 |
T10772 |
prep |
of,process |
R6725 |
T10775 |
T10774 |
pobj |
silencing,of |
R6726 |
T10776 |
T10758 |
punct |
.,escape |
R6727 |
T10778 |
T10779 |
prep |
In,inactivated |
R6728 |
T10780 |
T10778 |
pobj |
both,In |
R6729 |
T10781 |
T10780 |
prep |
of,both |
R6730 |
T10782 |
T10783 |
det |
these,cases |
R6731 |
T10783 |
T10781 |
pobj |
cases,of |
R6732 |
T10784 |
T10779 |
punct |
", ",inactivated |
R6733 |
T10785 |
T10786 |
amod |
other,genes |
R6734 |
T10786 |
T10779 |
nsubjpass |
genes,inactivated |
R6735 |
T10787 |
T10786 |
prep |
on,genes |
R6736 |
T10788 |
T10789 |
det |
the,chromosome |
R6737 |
T10789 |
T10787 |
pobj |
chromosome,on |
R6738 |
T10790 |
T10789 |
amod |
paternal,chromosome |
R6739 |
T10791 |
T10789 |
compound |
X,chromosome |
R6740 |
T10792 |
T10779 |
aux |
must,inactivated |
R6741 |
T10793 |
T10779 |
auxpass |
be,inactivated |
R6742 |
T10794 |
T10779 |
cc |
and,inactivated |
R6743 |
T10795 |
T10779 |
conj |
remain,inactivated |
R6744 |
T10796 |
T10795 |
advmod |
so,remain |
R6745 |
T10797 |
T10779 |
punct |
", ",inactivated |
R6746 |
T10798 |
T10799 |
mark |
since,causes |
R6747 |
T10799 |
T10779 |
advcl |
causes,inactivated |
R6748 |
T10800 |
T10801 |
amod |
blocking,inactivation |
R6749 |
T10801 |
T10799 |
nsubj |
inactivation,causes |
R6750 |
T10802 |
T10801 |
prep |
of,inactivation |
R6751 |
T10803 |
T10804 |
det |
the,chromosome |
R6752 |
T10804 |
T10802 |
pobj |
chromosome,of |
R6753 |
T10805 |
T10804 |
amod |
entire,chromosome |
R6754 |
T10806 |
T10804 |
compound |
Xp,chromosome |
R6755 |
T10807 |
T10808 |
amod |
embryonic,lethality |
R6756 |
T10808 |
T10799 |
dobj |
lethality,causes |
R6757 |
T10809 |
T10799 |
prep |
due,causes |
R6758 |
T10810 |
T10809 |
pcomp |
to,due |
R6759 |
T10811 |
T10812 |
amod |
biallelic,expression |
R6760 |
T10812 |
T10809 |
pobj |
expression,due |
R6761 |
T10813 |
T10812 |
prep |
of,expression |
R6762 |
T10814 |
T10815 |
npadvmod |
X,linked |
R6763 |
T10815 |
T10817 |
amod |
linked,genes |
R6764 |
T10816 |
T10815 |
punct |
-,linked |
R6765 |
T10817 |
T10813 |
pobj |
genes,of |
R6766 |
T10818 |
T10812 |
prep |
in,expression |
R6767 |
T10819 |
T10820 |
det |
the,trophoblast |
R6768 |
T10820 |
T10818 |
pobj |
trophoblast,in |
R6769 |
T10821 |
T10822 |
punct |
[,39 |
R6770 |
T10822 |
T10779 |
parataxis |
39,inactivated |
R6771 |
T10823 |
T10822 |
punct |
],39 |
R6772 |
T10824 |
T10779 |
punct |
.,inactivated |