PMC:1440874 / 37756-44130 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T8323	0-2	DT	denotes	An
T8324	14-18	NN	denotes	Role
T8325	3-13	JJ	denotes	Unexpected
T8326	19-22	IN	denotes	for
T8327	23-27	NN	denotes	Atrx
T8328	28-30	IN	denotes	in
T8329	31-42	NN	denotes	Development
T8330	43-45	IN	denotes	of
T8331	46-49	DT	denotes	the
T8332	56-67	NN	denotes	Trophoblast
T8333	50-55	NN	denotes	Mouse
T8334	67-149	sentence	denotes	We show that Atrxnull male mice are not viable and embryos die by around 9.5 dpc.
T8335	68-70	PRP	denotes	We
T8336	71-75	VBP	denotes	show
T8337	76-80	IN	denotes	that
T8338	100-103	VBP	denotes	are
T8339	81-89	JJ	denotes	Atrxnull
T8340	95-99	NNS	denotes	mice
T8341	90-94	JJ	denotes	male
T8342	104-107	RB	denotes	not
T8343	108-114	JJ	denotes	viable
T8344	115-118	CC	denotes	and
T8345	119-126	NNS	denotes	embryos
T8346	127-130	VBP	denotes	die
T8347	131-133	IN	denotes	by
T8348	134-140	IN	denotes	around
T8349	141-144	CD	denotes	9.5
T8350	145-148	NN	denotes	dpc
T8351	148-149	.	denotes	.
T8352	149-257	sentence	denotes	Before death, Atrxnull embryos exhibit a markedly reduced mitotic index, suggesting a proliferative defect.
T8353	150-156	IN	denotes	Before
T8354	181-188	VBP	denotes	exhibit
T8355	157-162	NN	denotes	death
T8356	162-164	,	denotes	,
T8357	164-172	JJ	denotes	Atrxnull
T8358	173-180	NNS	denotes	embryos
T8359	189-190	DT	denotes	a
T8360	216-221	NN	denotes	index
T8361	191-199	RB	denotes	markedly
T8362	200-207	VBN	denotes	reduced
T8363	208-215	JJ	denotes	mitotic
T8364	221-223	,	denotes	,
T8365	223-233	VBG	denotes	suggesting
T8366	234-235	DT	denotes	a
T8367	250-256	NN	denotes	defect
T8368	236-249	JJ	denotes	proliferative
T8369	256-257	.	denotes	.
T8370	257-604	sentence	denotes	Although the embryonic compartment of the conceptus appears initially normal, by 7.5 dpc Atrxnull embryos display abnormalities in development of the trophoblast, including a depletion in the population of TGCs surrounding the conceptus and a reduction in the size of the ectoplacental cone, which contains the diploid giant cell precursors [22].
T8371	258-266	IN	denotes	Although
T8372	310-317	VBZ	denotes	appears
T8373	267-270	DT	denotes	the
T8374	281-292	NN	denotes	compartment
T8375	271-280	JJ	denotes	embryonic
T8376	293-295	IN	denotes	of
T8377	296-299	DT	denotes	the
T8378	300-309	NN	denotes	conceptus
T8379	364-371	VBP	denotes	display
T8380	318-327	RB	denotes	initially
T8381	328-334	JJ	denotes	normal
T8382	334-336	,	denotes	,
T8383	336-338	IN	denotes	by
T8384	339-342	CD	denotes	7.5
T8385	343-346	NN	denotes	dpc
T8386	347-355	JJ	denotes	Atrxnull
T8387	356-363	NNS	denotes	embryos
T8388	372-385	NNS	denotes	abnormalities
T8389	386-388	IN	denotes	in
T8390	389-400	NN	denotes	development
T8391	401-403	IN	denotes	of
T8392	404-407	DT	denotes	the
T8393	408-419	NN	denotes	trophoblast
T8394	419-421	,	denotes	,
T8395	421-430	VBG	denotes	including
T8396	431-432	DT	denotes	a
T8397	433-442	NN	denotes	depletion
T8398	443-445	IN	denotes	in
T8399	446-449	DT	denotes	the
T8400	450-460	NN	denotes	population
T8401	461-463	IN	denotes	of
T8402	464-468	NNS	denotes	TGCs
T8403	469-480	VBG	denotes	surrounding
T8404	481-484	DT	denotes	the
T8405	485-494	NN	denotes	conceptus
T8406	495-498	CC	denotes	and
T8407	499-500	DT	denotes	a
T8408	501-510	NN	denotes	reduction
T8409	511-513	IN	denotes	in
T8410	514-517	DT	denotes	the
T8411	518-522	NN	denotes	size
T8412	523-525	IN	denotes	of
T8413	526-529	DT	denotes	the
T8414	544-548	NN	denotes	cone
T8415	530-543	JJ	denotes	ectoplacental
T8416	548-550	,	denotes	,
T8417	550-555	WDT	denotes	which
T8418	556-564	VBZ	denotes	contains
T8419	565-568	DT	denotes	the
T8420	588-598	NNS	denotes	precursors
T8421	569-576	NN	denotes	diploid
T8422	577-582	JJ	denotes	giant
T8423	583-587	NN	denotes	cell
T8424	599-600	-LRB-	denotes	[
T8425	600-602	CD	denotes	22
T8426	602-603	-RRB-	denotes	]
T8427	603-604	.	denotes	.
T8428	604-791	sentence	denotes	TGCs are highly differentiated, postmitotic cells that ultimately form an epithelial layer at the periphery of the placenta, which interfaces with the maternal cells of the decidua [23].
T8429	605-609	NNS	denotes	TGCs
T8430	610-613	VBP	denotes	are
T8431	614-620	RB	denotes	highly
T8432	621-635	VBN	denotes	differentiated
T8433	649-654	NNS	denotes	cells
T8434	635-637	,	denotes	,
T8435	637-648	JJ	denotes	postmitotic
T8436	655-659	WDT	denotes	that
T8437	671-675	VBP	denotes	form
T8438	660-670	RB	denotes	ultimately
T8439	676-678	DT	denotes	an
T8440	690-695	NN	denotes	layer
T8441	679-689	JJ	denotes	epithelial
T8442	696-698	IN	denotes	at
T8443	699-702	DT	denotes	the
T8444	703-712	NN	denotes	periphery
T8445	713-715	IN	denotes	of
T8446	716-719	DT	denotes	the
T8447	720-728	NN	denotes	placenta
T8448	728-730	,	denotes	,
T8449	730-735	WDT	denotes	which
T8450	736-746	VBZ	denotes	interfaces
T8451	747-751	IN	denotes	with
T8452	752-755	DT	denotes	the
T8453	765-770	NNS	denotes	cells
T8454	756-764	JJ	denotes	maternal
T8455	771-773	IN	denotes	of
T8456	774-777	DT	denotes	the
T8457	778-785	NN	denotes	decidua
T8458	786-787	-LRB-	denotes	[
T8459	787-789	CD	denotes	23
T8460	789-790	-RRB-	denotes	]
T8461	790-791	.	denotes	.
T8462	791-1036	sentence	denotes	These highly invasive cells are important for mediating initial invasion of the uterine tissue, but are also involved in remodelling the maternal decidua after implantation and in secreting hormones that regulate fetal and maternal growth [24].
T8463	792-797	DT	denotes	These
T8464	814-819	NNS	denotes	cells
T8465	798-804	RB	denotes	highly
T8466	805-813	JJ	denotes	invasive
T8467	820-823	VBP	denotes	are
T8468	824-833	JJ	denotes	important
T8469	834-837	IN	denotes	for
T8470	838-847	VBG	denotes	mediating
T8471	848-855	JJ	denotes	initial
T8472	856-864	NN	denotes	invasion
T8473	865-867	IN	denotes	of
T8474	868-871	DT	denotes	the
T8475	880-886	NN	denotes	tissue
T8476	872-879	JJ	denotes	uterine
T8477	886-888	,	denotes	,
T8478	888-891	CC	denotes	but
T8479	892-895	VBP	denotes	are
T8480	901-909	VBN	denotes	involved
T8481	896-900	RB	denotes	also
T8482	910-912	IN	denotes	in
T8483	913-924	VBG	denotes	remodelling
T8484	925-928	DT	denotes	the
T8485	938-945	NN	denotes	decidua
T8486	929-937	JJ	denotes	maternal
T8487	946-951	IN	denotes	after
T8488	952-964	NN	denotes	implantation
T8489	965-968	CC	denotes	and
T8490	969-971	IN	denotes	in
T8491	972-981	VBG	denotes	secreting
T8492	982-990	NNS	denotes	hormones
T8493	991-995	WDT	denotes	that
T8494	996-1004	VBP	denotes	regulate
T8495	1005-1010	JJ	denotes	fetal
T8496	1024-1030	NN	denotes	growth
T8497	1011-1014	CC	denotes	and
T8498	1015-1023	JJ	denotes	maternal
T8499	1031-1032	-LRB-	denotes	[
T8500	1032-1034	CD	denotes	24
T8501	1034-1035	-RRB-	denotes	]
T8502	1035-1036	.	denotes	.
T8503	1036-1175	sentence	denotes	Since Atrxnull embryos appear to implant normally, lethality is likely to arise due to a failure of TGC function later during development.
T8504	1037-1042	IN	denotes	Since
T8505	1060-1066	VBP	denotes	appear
T8506	1043-1051	JJ	denotes	Atrxnull
T8507	1052-1059	NNS	denotes	embryos
T8508	1098-1100	VBZ	denotes	is
T8509	1067-1069	TO	denotes	to
T8510	1070-1077	VB	denotes	implant
T8511	1078-1086	RB	denotes	normally
T8512	1086-1088	,	denotes	,
T8513	1088-1097	NN	denotes	lethality
T8514	1101-1107	JJ	denotes	likely
T8515	1108-1110	TO	denotes	to
T8516	1111-1116	VB	denotes	arise
T8517	1117-1120	IN	denotes	due
T8518	1121-1123	IN	denotes	to
T8519	1124-1125	DT	denotes	a
T8520	1126-1133	NN	denotes	failure
T8521	1134-1136	IN	denotes	of
T8522	1137-1140	NN	denotes	TGC
T8523	1141-1149	NN	denotes	function
T8524	1150-1155	RB	denotes	later
T8525	1156-1162	IN	denotes	during
T8526	1163-1174	NN	denotes	development
T8527	1174-1175	.	denotes	.
T8528	1175-1328	sentence	denotes	Embryonic lethality in mice in the absence of Atrx was a surprising finding, as there had been no suggestion of foetal loss in the human ATR-X syndrome.
T8529	1176-1185	JJ	denotes	Embryonic
T8530	1186-1195	NN	denotes	lethality
T8531	1227-1230	VBD	denotes	was
T8532	1196-1198	IN	denotes	in
T8533	1199-1203	NNS	denotes	mice
T8534	1204-1206	IN	denotes	in
T8535	1207-1210	DT	denotes	the
T8536	1211-1218	NN	denotes	absence
T8537	1219-1221	IN	denotes	of
T8538	1222-1226	NN	denotes	Atrx
T8539	1231-1232	DT	denotes	a
T8540	1244-1251	NN	denotes	finding
T8541	1233-1243	JJ	denotes	surprising
T8542	1251-1253	,	denotes	,
T8543	1253-1255	IN	denotes	as
T8544	1266-1270	VBN	denotes	been
T8545	1256-1261	EX	denotes	there
T8546	1262-1265	VBD	denotes	had
T8547	1271-1273	DT	denotes	no
T8548	1274-1284	NN	denotes	suggestion
T8549	1285-1287	IN	denotes	of
T8550	1288-1294	JJ	denotes	foetal
T8551	1295-1299	NN	denotes	loss
T8552	1300-1302	IN	denotes	in
T8553	1303-1306	DT	denotes	the
T8554	1319-1327	NN	denotes	syndrome
T8555	1307-1312	JJ	denotes	human
T8556	1313-1316	NN	denotes	ATR
T8557	1317-1318	NN	denotes	X
T8558	1316-1317	HYPH	denotes	-
T8559	1327-1328	.	denotes	.
T8560	1328-1472	sentence	denotes	It is possible that the role of Atrx in the trophoblast is specific to mice and that ATRX has no role or is redundant in the human trophoblast.
T8561	1329-1331	PRP	denotes	It
T8562	1332-1334	VBZ	denotes	is
T8563	1335-1343	JJ	denotes	possible
T8564	1344-1348	IN	denotes	that
T8565	1385-1387	VBZ	denotes	is
T8566	1349-1352	DT	denotes	the
T8567	1353-1357	NN	denotes	role
T8568	1358-1360	IN	denotes	of
T8569	1361-1365	NN	denotes	Atrx
T8570	1366-1368	IN	denotes	in
T8571	1369-1372	DT	denotes	the
T8572	1373-1384	NN	denotes	trophoblast
T8573	1388-1396	JJ	denotes	specific
T8574	1397-1399	IN	denotes	to
T8575	1400-1404	NNS	denotes	mice
T8576	1405-1408	CC	denotes	and
T8577	1409-1413	IN	denotes	that
T8578	1419-1422	VBZ	denotes	has
T8579	1414-1418	NN	denotes	ATRX
T8580	1423-1425	DT	denotes	no
T8581	1426-1430	NN	denotes	role
T8582	1431-1433	CC	denotes	or
T8583	1434-1436	VBZ	denotes	is
T8584	1437-1446	JJ	denotes	redundant
T8585	1447-1449	IN	denotes	in
T8586	1450-1453	DT	denotes	the
T8587	1460-1471	NN	denotes	trophoblast
T8588	1454-1459	JJ	denotes	human
T8589	1471-1472	.	denotes	.
T8590	1472-1546	sentence	denotes	Indeed, the birth weight of babies with ATR-X syndrome is usually normal.
T8591	1473-1479	RB	denotes	Indeed
T8592	1528-1530	VBZ	denotes	is
T8593	1479-1481	,	denotes	,
T8594	1481-1484	DT	denotes	the
T8595	1491-1497	NN	denotes	weight
T8596	1485-1490	NN	denotes	birth
T8597	1498-1500	IN	denotes	of
T8598	1501-1507	NNS	denotes	babies
T8599	1508-1512	IN	denotes	with
T8600	1513-1516	NN	denotes	ATR
T8601	1517-1518	NN	denotes	X
T8602	1516-1517	HYPH	denotes	-
T8603	1519-1527	NN	denotes	syndrome
T8604	1531-1538	RB	denotes	usually
T8605	1539-1545	JJ	denotes	normal
T8606	1545-1546	.	denotes	.
T8607	1546-1753	sentence	denotes	An alternative explanation for the unexpectedly severe phenotype we observed in mice is that the Atrx Δ18Δneo deletion generated by Cre recombination completely ablates full-length Atrx protein (Figure 2E).
T8608	1547-1549	DT	denotes	An
T8609	1562-1573	NN	denotes	explanation
T8610	1550-1561	JJ	denotes	alternative
T8611	1632-1634	VBZ	denotes	is
T8612	1574-1577	IN	denotes	for
T8613	1578-1581	DT	denotes	the
T8614	1602-1611	NN	denotes	phenotype
T8615	1582-1594	RB	denotes	unexpectedly
T8616	1595-1601	JJ	denotes	severe
T8617	1612-1614	PRP	denotes	we
T8618	1615-1623	VBD	denotes	observed
T8619	1624-1626	IN	denotes	in
T8620	1627-1631	NNS	denotes	mice
T8621	1635-1639	IN	denotes	that
T8622	1708-1715	VBZ	denotes	ablates
T8623	1640-1643	DT	denotes	the
T8624	1657-1665	NN	denotes	deletion
T8625	1644-1656	NN	denotes	Atrx Δ18Δneo
T8626	1666-1675	VBN	denotes	generated
T8627	1676-1678	IN	denotes	by
T8628	1679-1682	NN	denotes	Cre
T8629	1683-1696	NN	denotes	recombination
T8630	1697-1707	RB	denotes	completely
T8631	1716-1720	JJ	denotes	full
T8632	1721-1727	NN	denotes	length
T8633	1720-1721	HYPH	denotes	-
T8634	1733-1740	NN	denotes	protein
T8635	1728-1732	NN	denotes	Atrx
T8636	1741-1742	-LRB-	denotes	(
T8637	1749-1751	NN	denotes	2E
T8638	1742-1748	NN	denotes	Figure
T8639	1751-1752	-RRB-	denotes	)
T8640	1752-1753	.	denotes	.
T8641	1753-1879	sentence	denotes	In contrast, all disease-causing mutations characterised in human ATR-X pedigrees appear to give rise to hypomorphic alleles.
T8642	1754-1756	IN	denotes	In
T8643	1836-1842	VBP	denotes	appear
T8644	1757-1765	NN	denotes	contrast
T8645	1765-1767	,	denotes	,
T8646	1767-1770	DT	denotes	all
T8647	1787-1796	NNS	denotes	mutations
T8648	1771-1778	NN	denotes	disease
T8649	1779-1786	VBG	denotes	causing
T8650	1778-1779	HYPH	denotes	-
T8651	1797-1810	VBN	denotes	characterised
T8652	1811-1813	IN	denotes	in
T8653	1814-1819	JJ	denotes	human
T8654	1826-1835	NNS	denotes	pedigrees
T8655	1820-1823	NN	denotes	ATR
T8656	1824-1825	NN	denotes	X
T8657	1823-1824	HYPH	denotes	-
T8658	1843-1845	TO	denotes	to
T8659	1846-1850	VB	denotes	give
T8660	1851-1855	NN	denotes	rise
T8661	1856-1858	IN	denotes	to
T8662	1859-1870	JJ	denotes	hypomorphic
T8663	1871-1878	NNS	denotes	alleles
T8664	1878-1879	.	denotes	.
T8665	1879-2199	sentence	denotes	Some full-length ATRX protein is detected in cases predicted to have truncating mutations (RJG, unpublished data), and residual ATPase activity in ATRX immunoprecipitates can be detected in Epstein-Barr virus-transformed lymphocytes of all human patients analysed to date (A. Argentaro and M. Mitson, unpublished data).
T8666	1880-1884	DT	denotes	Some
T8667	1902-1909	NN	denotes	protein
T8668	1885-1889	JJ	denotes	full
T8669	1890-1896	NN	denotes	length
T8670	1889-1890	HYPH	denotes	-
T8671	1897-1901	NN	denotes	ATRX
T8672	1913-1921	VBN	denotes	detected
T8673	1910-1912	VBZ	denotes	is
T8674	1922-1924	IN	denotes	in
T8675	1925-1930	NNS	denotes	cases
T8676	1931-1940	VBN	denotes	predicted
T8677	1941-1943	TO	denotes	to
T8678	1944-1948	VB	denotes	have
T8679	1949-1959	NN	denotes	truncating
T8680	1960-1969	NNS	denotes	mutations
T8681	1970-1971	-LRB-	denotes	(
T8682	1988-1992	NNS	denotes	data
T8683	1971-1974	NN	denotes	RJG
T8684	1974-1976	,	denotes	,
T8685	1976-1987	JJ	denotes	unpublished
T8686	1992-1993	-RRB-	denotes	)
T8687	1993-1995	,	denotes	,
T8688	1995-1998	CC	denotes	and
T8689	1999-2007	JJ	denotes	residual
T8690	2015-2023	NN	denotes	activity
T8691	2008-2014	NN	denotes	ATPase
T8692	2058-2066	VBN	denotes	detected
T8693	2024-2026	IN	denotes	in
T8694	2027-2031	NN	denotes	ATRX
T8695	2032-2050	NNS	denotes	immunoprecipitates
T8696	2051-2054	MD	denotes	can
T8697	2055-2057	VB	denotes	be
T8698	2067-2069	IN	denotes	in
T8699	2070-2077	NN	denotes	Epstein
T8700	2078-2082	NN	denotes	Barr
T8701	2077-2078	HYPH	denotes	-
T8702	2083-2088	NN	denotes	virus
T8703	2089-2100	VBN	denotes	transformed
T8704	2088-2089	HYPH	denotes	-
T8705	2101-2112	NNS	denotes	lymphocytes
T8706	2113-2115	IN	denotes	of
T8707	2116-2119	DT	denotes	all
T8708	2126-2134	NNS	denotes	patients
T8709	2120-2125	JJ	denotes	human
T8710	2135-2143	VBN	denotes	analysed
T8711	2144-2146	IN	denotes	to
T8712	2147-2151	NN	denotes	date
T8713	2152-2153	-LRB-	denotes	(
T8714	2153-2155	NNP	denotes	A.
T8715	2156-2165	NNP	denotes	Argentaro
T8716	2166-2169	CC	denotes	and
T8717	2170-2172	NNP	denotes	M.
T8718	2173-2179	NNP	denotes	Mitson
T8719	2179-2181	,	denotes	,
T8720	2181-2192	JJ	denotes	unpublished
T8721	2193-2197	NNS	denotes	data
T8722	2197-2198	-RRB-	denotes	)
T8723	2198-2199	.	denotes	.
T8724	2199-2389	sentence	denotes	The failure to observe a truly null ATRX allele among human patients strongly suggests that, as in the mouse, the complete absence of ATRX protein is incompatible with human fetal survival.
T8725	2200-2203	DT	denotes	The
T8726	2204-2211	NN	denotes	failure
T8727	2278-2286	VBZ	denotes	suggests
T8728	2212-2214	TO	denotes	to
T8729	2215-2222	VB	denotes	observe
T8730	2223-2224	DT	denotes	a
T8731	2241-2247	NN	denotes	allele
T8732	2225-2230	RB	denotes	truly
T8733	2231-2235	JJ	denotes	null
T8734	2236-2240	NN	denotes	ATRX
T8735	2248-2253	IN	denotes	among
T8736	2254-2259	JJ	denotes	human
T8737	2260-2268	NNS	denotes	patients
T8738	2269-2277	RB	denotes	strongly
T8739	2287-2291	IN	denotes	that
T8740	2347-2349	VBZ	denotes	is
T8741	2291-2293	,	denotes	,
T8742	2293-2295	IN	denotes	as
T8743	2296-2298	IN	denotes	in
T8744	2299-2302	DT	denotes	the
T8745	2303-2308	NN	denotes	mouse
T8746	2308-2310	,	denotes	,
T8747	2310-2313	DT	denotes	the
T8748	2323-2330	NN	denotes	absence
T8749	2314-2322	JJ	denotes	complete
T8750	2331-2333	IN	denotes	of
T8751	2334-2338	NN	denotes	ATRX
T8752	2339-2346	NN	denotes	protein
T8753	2350-2362	JJ	denotes	incompatible
T8754	2363-2367	IN	denotes	with
T8755	2368-2373	JJ	denotes	human
T8756	2380-2388	NN	denotes	survival
T8757	2374-2379	JJ	denotes	fetal
T8758	2388-2389	.	denotes	.
T8759	2389-2655	sentence	denotes	While this study has revealed an unexpected role for Atrx in the murine trophectoderm, as a result of the early lethality observed in Atrxnull embryos it is not possible to rule out other roles for Atrx at later developmental stages in tissues of the embryo proper.
T8760	2390-2395	IN	denotes	While
T8761	2411-2419	VBN	denotes	revealed
T8762	2396-2400	DT	denotes	this
T8763	2401-2406	NN	denotes	study
T8764	2407-2410	VBZ	denotes	has
T8765	2544-2546	VBZ	denotes	is
T8766	2420-2422	DT	denotes	an
T8767	2434-2438	NN	denotes	role
T8768	2423-2433	JJ	denotes	unexpected
T8769	2439-2442	IN	denotes	for
T8770	2443-2447	NN	denotes	Atrx
T8771	2448-2450	IN	denotes	in
T8772	2451-2454	DT	denotes	the
T8773	2462-2475	NN	denotes	trophectoderm
T8774	2455-2461	JJ	denotes	murine
T8775	2475-2477	,	denotes	,
T8776	2477-2479	IN	denotes	as
T8777	2480-2481	DT	denotes	a
T8778	2482-2488	NN	denotes	result
T8779	2489-2491	IN	denotes	of
T8780	2492-2495	DT	denotes	the
T8781	2502-2511	NN	denotes	lethality
T8782	2496-2501	JJ	denotes	early
T8783	2512-2520	VBN	denotes	observed
T8784	2521-2523	IN	denotes	in
T8785	2524-2532	JJ	denotes	Atrxnull
T8786	2533-2540	NNS	denotes	embryos
T8787	2541-2543	PRP	denotes	it
T8788	2547-2550	RB	denotes	not
T8789	2551-2559	JJ	denotes	possible
T8790	2560-2562	TO	denotes	to
T8791	2563-2567	VB	denotes	rule
T8792	2568-2571	RP	denotes	out
T8793	2572-2577	JJ	denotes	other
T8794	2578-2583	NNS	denotes	roles
T8795	2584-2587	IN	denotes	for
T8796	2588-2592	NN	denotes	Atrx
T8797	2593-2595	IN	denotes	at
T8798	2596-2601	JJ	denotes	later
T8799	2616-2622	NNS	denotes	stages
T8800	2602-2615	JJ	denotes	developmental
T8801	2623-2625	IN	denotes	in
T8802	2626-2633	NNS	denotes	tissues
T8803	2634-2636	IN	denotes	of
T8804	2637-2640	DT	denotes	the
T8805	2641-2647	NN	denotes	embryo
T8806	2648-2654	JJ	denotes	proper
T8807	2654-2655	.	denotes	.
T8808	2655-2866	sentence	denotes	Indeed, we show that Atrx is highly expressed throughout the entire developing embryo at 7.5 dpc (Figure 5B), and it is likely that Atrx function will turn out to be important for other differentiating tissues.
T8809	2656-2662	RB	denotes	Indeed
T8810	2667-2671	VBP	denotes	show
T8811	2662-2664	,	denotes	,
T8812	2664-2666	PRP	denotes	we
T8813	2672-2676	IN	denotes	that
T8814	2682-2684	VBZ	denotes	is
T8815	2677-2681	NN	denotes	Atrx
T8816	2685-2691	RB	denotes	highly
T8817	2692-2701	JJ	denotes	expressed
T8818	2702-2712	IN	denotes	throughout
T8819	2713-2716	DT	denotes	the
T8820	2735-2741	NN	denotes	embryo
T8821	2717-2723	JJ	denotes	entire
T8822	2724-2734	VBG	denotes	developing
T8823	2742-2744	IN	denotes	at
T8824	2745-2748	CD	denotes	7.5
T8825	2749-2752	NN	denotes	dpc
T8826	2753-2754	-LRB-	denotes	(
T8827	2761-2763	NN	denotes	5B
T8828	2754-2760	NN	denotes	Figure
T8829	2763-2764	-RRB-	denotes	)
T8830	2764-2766	,	denotes	,
T8831	2766-2769	CC	denotes	and
T8832	2770-2772	PRP	denotes	it
T8833	2773-2775	VBZ	denotes	is
T8834	2776-2782	JJ	denotes	likely
T8835	2783-2787	IN	denotes	that
T8836	2807-2811	VB	denotes	turn
T8837	2788-2792	NN	denotes	Atrx
T8838	2793-2801	NN	denotes	function
T8839	2802-2806	MD	denotes	will
T8840	2812-2815	RP	denotes	out
T8841	2816-2818	TO	denotes	to
T8842	2819-2821	VB	denotes	be
T8843	2822-2831	JJ	denotes	important
T8844	2832-2835	IN	denotes	for
T8845	2836-2841	JJ	denotes	other
T8846	2858-2865	NNS	denotes	tissues
T8847	2842-2857	VBG	denotes	differentiating
T8848	2865-2866	.	denotes	.
T8849	2866-3213	sentence	denotes	Tetraploid aggregation experiments (in which mutant embryos are rescued with wild-type extraembryonic tissues) might shed more light on the role of Atrx during later mouse development, but these issues can be more subtly dissected by combining the conditional Atrx flox allele that we have generated with different tissue-specific Cre transgenes.
T8850	2867-2877	NN	denotes	Tetraploid
T8851	2878-2889	NN	denotes	aggregation
T8852	2890-2901	NNS	denotes	experiments
T8853	2984-2988	VB	denotes	shed
T8854	2902-2903	-LRB-	denotes	(
T8855	2903-2905	IN	denotes	in
T8856	2931-2938	VBN	denotes	rescued
T8857	2906-2911	WDT	denotes	which
T8858	2912-2918	NN	denotes	mutant
T8859	2919-2926	NNS	denotes	embryos
T8860	2927-2930	VBP	denotes	are
T8861	2939-2943	IN	denotes	with
T8862	2944-2948	JJ	denotes	wild
T8863	2949-2953	NN	denotes	type
T8864	2948-2949	HYPH	denotes	-
T8865	2969-2976	NNS	denotes	tissues
T8866	2954-2968	JJ	denotes	extraembryonic
T8867	2976-2977	-RRB-	denotes	)
T8868	2978-2983	MD	denotes	might
T8869	2989-2993	JJR	denotes	more
T8870	2994-2999	NN	denotes	light
T8871	3000-3002	IN	denotes	on
T8872	3003-3006	DT	denotes	the
T8873	3007-3011	NN	denotes	role
T8874	3012-3014	IN	denotes	of
T8875	3015-3019	NN	denotes	Atrx
T8876	3020-3026	IN	denotes	during
T8877	3027-3032	JJ	denotes	later
T8878	3039-3050	NN	denotes	development
T8879	3033-3038	NN	denotes	mouse
T8880	3050-3052	,	denotes	,
T8881	3052-3055	CC	denotes	but
T8882	3056-3061	DT	denotes	these
T8883	3062-3068	NNS	denotes	issues
T8884	3088-3097	VBN	denotes	dissected
T8885	3069-3072	MD	denotes	can
T8886	3073-3075	VB	denotes	be
T8887	3076-3080	RBR	denotes	more
T8888	3081-3087	RB	denotes	subtly
T8889	3098-3100	IN	denotes	by
T8890	3101-3110	VBG	denotes	combining
T8891	3111-3114	DT	denotes	the
T8892	3137-3143	NN	denotes	allele
T8893	3115-3126	JJ	denotes	conditional
T8894	3127-3136	NN	denotes	Atrx flox
T8895	3144-3148	WDT	denotes	that
T8896	3157-3166	VBN	denotes	generated
T8897	3149-3151	PRP	denotes	we
T8898	3152-3156	VBP	denotes	have
T8899	3167-3171	IN	denotes	with
T8900	3172-3181	JJ	denotes	different
T8901	3202-3212	NNS	denotes	transgenes
T8902	3182-3188	NN	denotes	tissue
T8903	3189-3197	JJ	denotes	specific
T8904	3188-3189	HYPH	denotes	-
T8905	3198-3201	NN	denotes	Cre
T8906	3212-3213	.	denotes	.
T8907	3213-3345	sentence	denotes	As mentioned above, this approach has already revealed a critical role for Atrx during neuronal differentiation in adult mice [20].
T8908	3214-3216	IN	denotes	As
T8909	3217-3226	VBN	denotes	mentioned
T8910	3260-3268	VBN	denotes	revealed
T8911	3227-3232	RB	denotes	above
T8912	3232-3234	,	denotes	,
T8913	3234-3238	DT	denotes	this
T8914	3239-3247	NN	denotes	approach
T8915	3248-3251	VBZ	denotes	has
T8916	3252-3259	RB	denotes	already
T8917	3269-3270	DT	denotes	a
T8918	3280-3284	NN	denotes	role
T8919	3271-3279	JJ	denotes	critical
T8920	3285-3288	IN	denotes	for
T8921	3289-3293	NN	denotes	Atrx
T8922	3294-3300	IN	denotes	during
T8923	3301-3309	JJ	denotes	neuronal
T8924	3310-3325	NN	denotes	differentiation
T8925	3326-3328	IN	denotes	in
T8926	3329-3334	JJ	denotes	adult
T8927	3335-3339	NNS	denotes	mice
T8928	3340-3341	-LRB-	denotes	[
T8929	3341-3343	CD	denotes	20
T8930	3343-3344	-RRB-	denotes	]
T8931	3344-3345	.	denotes	.
T8932	3345-3703	sentence	denotes	Further evidence that Atrx is also required at later stages of mouse development is provided by the observed dramatic skewing against Atrx-negative cells in some somatic tissues of carrier female mice, whose tissues initially comprise a mosaic of Atrx-positive and Atrx-negative cells as a result of random X-inactivation (M. Muers, personal communication).
T8933	3346-3353	JJ	denotes	Further
T8934	3354-3362	NN	denotes	evidence
T8935	3430-3438	VBN	denotes	provided
T8936	3363-3367	IN	denotes	that
T8937	3381-3389	VBN	denotes	required
T8938	3368-3372	NN	denotes	Atrx
T8939	3373-3375	VBZ	denotes	is
T8940	3376-3380	RB	denotes	also
T8941	3390-3392	IN	denotes	at
T8942	3393-3398	JJ	denotes	later
T8943	3399-3405	NNS	denotes	stages
T8944	3406-3408	IN	denotes	of
T8945	3409-3414	NN	denotes	mouse
T8946	3415-3426	NN	denotes	development
T8947	3427-3429	VBZ	denotes	is
T8948	3439-3441	IN	denotes	by
T8949	3442-3445	DT	denotes	the
T8950	3464-3471	NN	denotes	skewing
T8951	3446-3454	VBN	denotes	observed
T8952	3455-3463	JJ	denotes	dramatic
T8953	3472-3479	IN	denotes	against
T8954	3480-3484	NN	denotes	Atrx
T8955	3494-3499	NNS	denotes	cells
T8956	3484-3485	HYPH	denotes	-
T8957	3485-3493	JJ	denotes	negative
T8958	3500-3502	IN	denotes	in
T8959	3503-3507	DT	denotes	some
T8960	3516-3523	NNS	denotes	tissues
T8961	3508-3515	JJ	denotes	somatic
T8962	3524-3526	IN	denotes	of
T8963	3527-3534	NN	denotes	carrier
T8964	3542-3546	NNS	denotes	mice
T8965	3535-3541	JJ	denotes	female
T8966	3546-3548	,	denotes	,
T8967	3548-3553	WP$	denotes	whose
T8968	3554-3561	NNS	denotes	tissues
T8969	3572-3580	VBP	denotes	comprise
T8970	3562-3571	RB	denotes	initially
T8971	3581-3582	DT	denotes	a
T8972	3583-3589	NN	denotes	mosaic
T8973	3590-3592	IN	denotes	of
T8974	3593-3597	NN	denotes	Atrx
T8975	3598-3606	JJ	denotes	positive
T8976	3597-3598	HYPH	denotes	-
T8977	3625-3630	NNS	denotes	cells
T8978	3607-3610	CC	denotes	and
T8979	3611-3615	NN	denotes	Atrx
T8980	3616-3624	JJ	denotes	negative
T8981	3615-3616	HYPH	denotes	-
T8982	3631-3633	IN	denotes	as
T8983	3634-3635	DT	denotes	a
T8984	3636-3642	NN	denotes	result
T8985	3643-3645	IN	denotes	of
T8986	3646-3652	JJ	denotes	random
T8987	3655-3667	NN	denotes	inactivation
T8988	3653-3654	NN	denotes	X
T8989	3654-3655	HYPH	denotes	-
T8990	3668-3669	-LRB-	denotes	(
T8991	3669-3671	NNP	denotes	M.
T8992	3672-3677	NNP	denotes	Muers
T8993	3677-3679	,	denotes	,
T8994	3679-3687	JJ	denotes	personal
T8995	3688-3701	NN	denotes	communication
T8996	3701-3702	-RRB-	denotes	)
T8997	3702-3703	.	denotes	.
T8998	3703-3890	sentence	denotes	Atrx joins an expanding list of mouse genes for which targeted disruption results in peri-implantation lethality as a result of trophoblast or placental abnormalities (reviewed in [25]).
T8999	3704-3708	NN	denotes	Atrx
T9000	3709-3714	VBZ	denotes	joins
T9001	3715-3717	DT	denotes	an
T9002	3728-3732	NN	denotes	list
T9003	3718-3727	VBG	denotes	expanding
T9004	3733-3735	IN	denotes	of
T9005	3736-3741	NN	denotes	mouse
T9006	3742-3747	NNS	denotes	genes
T9007	3748-3751	IN	denotes	for
T9008	3778-3785	VBZ	denotes	results
T9009	3752-3757	WDT	denotes	which
T9010	3758-3766	VBN	denotes	targeted
T9011	3767-3777	NN	denotes	disruption
T9012	3786-3788	IN	denotes	in
T9013	3789-3806	JJ	denotes	peri-implantation
T9014	3807-3816	NN	denotes	lethality
T9015	3817-3819	IN	denotes	as
T9016	3820-3821	DT	denotes	a
T9017	3822-3828	NN	denotes	result
T9018	3829-3831	IN	denotes	of
T9019	3832-3843	NN	denotes	trophoblast
T9020	3857-3870	NNS	denotes	abnormalities
T9021	3844-3846	CC	denotes	or
T9022	3847-3856	JJ	denotes	placental
T9023	3871-3872	-LRB-	denotes	(
T9024	3872-3880	VBN	denotes	reviewed
T9025	3881-3883	IN	denotes	in
T9026	3884-3885	-LRB-	denotes	[
T9027	3885-3887	CD	denotes	25
T9028	3887-3888	-RRB-	denotes	]
T9029	3888-3889	-RRB-	denotes	)
T9030	3889-3890	.	denotes	.
T9031	3890-4000	sentence	denotes	Comparison with other phenotypes might provide some insight into the role of Atrx in trophoblast development.
T9032	3891-3901	NN	denotes	Comparison
T9033	3930-3937	VB	denotes	provide
T9034	3902-3906	IN	denotes	with
T9035	3907-3912	JJ	denotes	other
T9036	3913-3923	NNS	denotes	phenotypes
T9037	3924-3929	MD	denotes	might
T9038	3938-3942	DT	denotes	some
T9039	3943-3950	NN	denotes	insight
T9040	3951-3955	IN	denotes	into
T9041	3956-3959	DT	denotes	the
T9042	3960-3964	NN	denotes	role
T9043	3965-3967	IN	denotes	of
T9044	3968-3972	NN	denotes	Atrx
T9045	3973-3975	IN	denotes	in
T9046	3976-3987	NN	denotes	trophoblast
T9047	3988-3999	NN	denotes	development
T9048	3999-4000	.	denotes	.
T9049	4000-4216	sentence	denotes	Atrx-mutant embryos progress further than embryos nullizygous for factors involved in the initial specification of trophoblast stem cells (such as Cdx2) or in stem cell maintenance and proliferation (such as Eomes).
T9050	4001-4005	NN	denotes	Atrx
T9051	4006-4012	NN	denotes	mutant
T9052	4005-4006	HYPH	denotes	-
T9053	4013-4020	NNS	denotes	embryos
T9054	4021-4029	VBP	denotes	progress
T9055	4030-4037	RB	denotes	further
T9056	4038-4042	IN	denotes	than
T9057	4043-4050	NNS	denotes	embryos
T9058	4051-4062	JJ	denotes	nullizygous
T9059	4063-4066	IN	denotes	for
T9060	4067-4074	NNS	denotes	factors
T9061	4075-4083	VBN	denotes	involved
T9062	4084-4086	IN	denotes	in
T9063	4087-4090	DT	denotes	the
T9064	4099-4112	NN	denotes	specification
T9065	4091-4098	JJ	denotes	initial
T9066	4113-4115	IN	denotes	of
T9067	4116-4127	NN	denotes	trophoblast
T9068	4133-4138	NNS	denotes	cells
T9069	4128-4132	NN	denotes	stem
T9070	4139-4140	-LRB-	denotes	(
T9071	4145-4147	IN	denotes	as
T9072	4140-4144	JJ	denotes	such
T9073	4148-4152	NN	denotes	Cdx2
T9074	4152-4153	-RRB-	denotes	)
T9075	4154-4156	CC	denotes	or
T9076	4157-4159	IN	denotes	in
T9077	4160-4164	NN	denotes	stem
T9078	4170-4181	NN	denotes	maintenance
T9079	4165-4169	NN	denotes	cell
T9080	4182-4185	CC	denotes	and
T9081	4186-4199	NN	denotes	proliferation
T9082	4200-4201	-LRB-	denotes	(
T9083	4206-4208	IN	denotes	as
T9084	4201-4205	JJ	denotes	such
T9085	4209-4214	NN	denotes	Eomes
T9086	4214-4215	-RRB-	denotes	)
T9087	4215-4216	.	denotes	.
T9088	4216-4452	sentence	denotes	Cdx2-mutant embryos fail to implant and die between 3.5 and 5.5 dpc [26], while Eomes-mutant blastocysts implant into the uterus, but arrest soon after implantation without forming organised embryonic or extraembryonic structures [27].
T9089	4217-4221	NN	denotes	Cdx2
T9090	4222-4228	NN	denotes	mutant
T9091	4221-4222	HYPH	denotes	-
T9092	4229-4236	NNS	denotes	embryos
T9093	4237-4241	VBP	denotes	fail
T9094	4242-4244	TO	denotes	to
T9095	4245-4252	VB	denotes	implant
T9096	4253-4256	CC	denotes	and
T9097	4257-4260	VBP	denotes	die
T9098	4261-4268	IN	denotes	between
T9099	4269-4272	CD	denotes	3.5
T9100	4281-4284	NN	denotes	dpc
T9101	4273-4276	CC	denotes	and
T9102	4277-4280	CD	denotes	5.5
T9103	4285-4286	-LRB-	denotes	[
T9104	4286-4288	CD	denotes	26
T9105	4288-4289	-RRB-	denotes	]
T9106	4289-4291	,	denotes	,
T9107	4291-4296	IN	denotes	while
T9108	4322-4329	VBP	denotes	implant
T9109	4297-4302	NN	denotes	Eomes
T9110	4303-4309	NN	denotes	mutant
T9111	4302-4303	HYPH	denotes	-
T9112	4310-4321	NNS	denotes	blastocysts
T9113	4330-4334	IN	denotes	into
T9114	4335-4338	DT	denotes	the
T9115	4339-4345	NN	denotes	uterus
T9116	4345-4347	,	denotes	,
T9117	4347-4350	CC	denotes	but
T9118	4351-4357	VBP	denotes	arrest
T9119	4358-4362	RB	denotes	soon
T9120	4363-4368	IN	denotes	after
T9121	4369-4381	NN	denotes	implantation
T9122	4382-4389	IN	denotes	without
T9123	4390-4397	VBG	denotes	forming
T9124	4398-4407	VBN	denotes	organised
T9125	4436-4446	NNS	denotes	structures
T9126	4408-4417	JJ	denotes	embryonic
T9127	4418-4420	CC	denotes	or
T9128	4421-4435	JJ	denotes	extraembryonic
T9129	4447-4448	-LRB-	denotes	[
T9130	4448-4450	CD	denotes	27
T9131	4450-4451	-RRB-	denotes	]
T9132	4451-4452	.	denotes	.
T9133	4452-4563	sentence	denotes	In contrast, Atrx-mutant embryos implant successfully and establish organised embryonic structures by 7.5 dpc.
T9134	4453-4455	IN	denotes	In
T9135	4486-4493	VBP	denotes	implant
T9136	4456-4464	NN	denotes	contrast
T9137	4464-4466	,	denotes	,
T9138	4466-4470	NN	denotes	Atrx
T9139	4471-4477	NN	denotes	mutant
T9140	4470-4471	HYPH	denotes	-
T9141	4478-4485	NNS	denotes	embryos
T9142	4494-4506	RB	denotes	successfully
T9143	4507-4510	CC	denotes	and
T9144	4511-4520	VBP	denotes	establish
T9145	4521-4530	VBN	denotes	organised
T9146	4541-4551	NNS	denotes	structures
T9147	4531-4540	JJ	denotes	embryonic
T9148	4552-4554	IN	denotes	by
T9149	4555-4558	CD	denotes	7.5
T9150	4559-4562	NN	denotes	dpc
T9151	4562-4563	.	denotes	.
T9152	4563-4700	sentence	denotes	The Atrx-mutant phenotype closely resembles that observed in mice nullizygous for the basic helix-loop-helix transcription factor Hand1.
T9153	4564-4567	DT	denotes	The
T9154	4580-4589	NN	denotes	phenotype
T9155	4568-4572	NN	denotes	Atrx
T9156	4573-4579	NN	denotes	mutant
T9157	4572-4573	HYPH	denotes	-
T9158	4598-4607	VBZ	denotes	resembles
T9159	4590-4597	RB	denotes	closely
T9160	4608-4612	DT	denotes	that
T9161	4613-4621	VBN	denotes	observed
T9162	4622-4624	IN	denotes	in
T9163	4625-4629	NNS	denotes	mice
T9164	4630-4641	JJ	denotes	nullizygous
T9165	4642-4645	IN	denotes	for
T9166	4646-4649	DT	denotes	the
T9167	4687-4693	NN	denotes	factor
T9168	4650-4655	JJ	denotes	basic
T9169	4656-4661	NN	denotes	helix
T9170	4667-4672	NN	denotes	helix
T9171	4661-4662	HYPH	denotes	-
T9172	4662-4666	NN	denotes	loop
T9173	4666-4667	HYPH	denotes	-
T9174	4673-4686	NN	denotes	transcription
T9175	4694-4699	NN	denotes	Hand1
T9176	4699-4700	.	denotes	.
T9177	4700-4926	sentence	denotes	Hand1-mutant conceptuses arrest at around 7.5 dpc and display a normal embryonic compartment, but, like Atrx-mutant embryos, ablation of Hand1 causes a reduction in the size of the ectoplacental cone and density of TGCs [28].
T9178	4701-4706	NN	denotes	Hand1
T9179	4707-4713	NN	denotes	mutant
T9180	4706-4707	HYPH	denotes	-
T9181	4714-4725	NNS	denotes	conceptuses
T9182	4726-4732	VBP	denotes	arrest
T9183	4733-4735	IN	denotes	at
T9184	4736-4742	IN	denotes	around
T9185	4743-4746	CD	denotes	7.5
T9186	4747-4750	NN	denotes	dpc
T9187	4751-4754	CC	denotes	and
T9188	4755-4762	VBP	denotes	display
T9189	4763-4764	DT	denotes	a
T9190	4782-4793	NN	denotes	compartment
T9191	4765-4771	JJ	denotes	normal
T9192	4772-4781	JJ	denotes	embryonic
T9193	4793-4795	,	denotes	,
T9194	4795-4798	CC	denotes	but
T9195	4798-4800	,	denotes	,
T9196	4800-4804	IN	denotes	like
T9197	4844-4850	VBZ	denotes	causes
T9198	4805-4809	NN	denotes	Atrx
T9199	4810-4816	NN	denotes	mutant
T9200	4809-4810	HYPH	denotes	-
T9201	4817-4824	NNS	denotes	embryos
T9202	4824-4826	,	denotes	,
T9203	4826-4834	NN	denotes	ablation
T9204	4835-4837	IN	denotes	of
T9205	4838-4843	NN	denotes	Hand1
T9206	4851-4852	DT	denotes	a
T9207	4853-4862	NN	denotes	reduction
T9208	4863-4865	IN	denotes	in
T9209	4866-4869	DT	denotes	the
T9210	4870-4874	NN	denotes	size
T9211	4875-4877	IN	denotes	of
T9212	4878-4881	DT	denotes	the
T9213	4896-4900	NN	denotes	cone
T9214	4882-4895	JJ	denotes	ectoplacental
T9215	4901-4904	CC	denotes	and
T9216	4905-4912	NN	denotes	density
T9217	4913-4915	IN	denotes	of
T9218	4916-4920	NNS	denotes	TGCs
T9219	4921-4922	-LRB-	denotes	[
T9220	4922-4924	CD	denotes	28
T9221	4924-4925	-RRB-	denotes	]
T9222	4925-4926	.	denotes	.
T9223	4926-5029	sentence	denotes	As with Atrx mutants, only arrested or resorbed Hand1-mutant conceptuses were recovered after 8.5 dpc.
T9224	4927-4929	IN	denotes	As
T9225	5005-5014	VBN	denotes	recovered
T9226	4930-4934	IN	denotes	with
T9227	4935-4939	NN	denotes	Atrx
T9228	4940-4947	NNS	denotes	mutants
T9229	4947-4949	,	denotes	,
T9230	4949-4953	RB	denotes	only
T9231	4988-4999	NNS	denotes	conceptuses
T9232	4954-4962	VBN	denotes	arrested
T9233	4963-4965	CC	denotes	or
T9234	4966-4974	VBN	denotes	resorbed
T9235	4975-4980	NN	denotes	Hand1
T9236	4981-4987	NN	denotes	mutant
T9237	4980-4981	HYPH	denotes	-
T9238	5000-5004	VBD	denotes	were
T9239	5015-5020	IN	denotes	after
T9240	5021-5024	CD	denotes	8.5
T9241	5025-5028	NN	denotes	dpc
T9242	5028-5029	.	denotes	.
T9243	5029-5187	sentence	denotes	Also like Atrx, disruption of Hand1 specifically affects secondary giant cell formation, and primary trophoblast outgrowths from blastocysts appeared normal.
T9244	5030-5034	RB	denotes	Also
T9245	5079-5086	VBZ	denotes	affects
T9246	5035-5039	IN	denotes	like
T9247	5040-5044	NN	denotes	Atrx
T9248	5044-5046	,	denotes	,
T9249	5046-5056	NN	denotes	disruption
T9250	5057-5059	IN	denotes	of
T9251	5060-5065	NN	denotes	Hand1
T9252	5066-5078	RB	denotes	specifically
T9253	5087-5096	JJ	denotes	secondary
T9254	5103-5107	NN	denotes	cell
T9255	5097-5102	JJ	denotes	giant
T9256	5108-5117	NN	denotes	formation
T9257	5117-5119	,	denotes	,
T9258	5119-5122	CC	denotes	and
T9259	5123-5130	JJ	denotes	primary
T9260	5143-5153	NNS	denotes	outgrowths
T9261	5131-5142	NN	denotes	trophoblast
T9262	5171-5179	VBD	denotes	appeared
T9263	5154-5158	IN	denotes	from
T9264	5159-5170	NNS	denotes	blastocysts
T9265	5180-5186	JJ	denotes	normal
T9266	5186-5187	.	denotes	.
T9267	5187-5353	sentence	denotes	Hand1 is required for terminal differentiation of secondary TGCs, and in its absence trophoblast cells arrest at a precursor stage in the ectoplacental cone [17,28].
T9268	5188-5193	NN	denotes	Hand1
T9269	5197-5205	VBN	denotes	required
T9270	5194-5196	VBZ	denotes	is
T9271	5206-5209	IN	denotes	for
T9272	5210-5218	JJ	denotes	terminal
T9273	5219-5234	NN	denotes	differentiation
T9274	5235-5237	IN	denotes	of
T9275	5238-5247	JJ	denotes	secondary
T9276	5248-5252	NNS	denotes	TGCs
T9277	5252-5254	,	denotes	,
T9278	5254-5257	CC	denotes	and
T9279	5258-5260	IN	denotes	in
T9280	5291-5297	VBP	denotes	arrest
T9281	5261-5264	PRP$	denotes	its
T9282	5265-5272	NN	denotes	absence
T9283	5273-5284	NN	denotes	trophoblast
T9284	5285-5290	NNS	denotes	cells
T9285	5298-5300	IN	denotes	at
T9286	5301-5302	DT	denotes	a
T9287	5313-5318	NN	denotes	stage
T9288	5303-5312	NN	denotes	precursor
T9289	5319-5321	IN	denotes	in
T9290	5322-5325	DT	denotes	the
T9291	5340-5344	NN	denotes	cone
T9292	5326-5339	JJ	denotes	ectoplacental
T9293	5345-5346	-LRB-	denotes	[
T9294	5349-5351	CD	denotes	28
T9295	5346-5348	CD	denotes	17
T9296	5348-5349	,	denotes	,
T9297	5351-5352	-RRB-	denotes	]
T9298	5352-5353	.	denotes	.
T9299	5353-5724	sentence	denotes	Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as a co-regulator of one or more of the downstream transcriptional targets of Hand1.
T9300	5354-5359	VBN	denotes	Given
T9301	5523-5525	VB	denotes	be
T9302	5360-5363	DT	denotes	the
T9303	5364-5374	NN	denotes	similarity
T9304	5375-5377	IN	denotes	of
T9305	5378-5381	DT	denotes	the
T9306	5405-5415	NNS	denotes	phenotypes
T9307	5382-5386	NN	denotes	Atrx
T9308	5398-5404	NN	denotes	mutant
T9309	5386-5387	HYPH	denotes	-
T9310	5388-5391	CC	denotes	and
T9311	5392-5397	NN	denotes	Hand1
T9312	5397-5398	HYPH	denotes	-
T9313	5416-5419	CC	denotes	and
T9314	5420-5423	DT	denotes	the
T9315	5424-5434	NN	denotes	likelihood
T9316	5435-5439	IN	denotes	that
T9317	5445-5449	VBZ	denotes	acts
T9318	5440-5444	NN	denotes	Atrx
T9319	5450-5452	IN	denotes	as
T9320	5453-5454	DT	denotes	a
T9321	5471-5480	NN	denotes	regulator
T9322	5455-5470	JJ	denotes	transcriptional
T9323	5481-5483	IN	denotes	by
T9324	5484-5493	VBG	denotes	modifying
T9325	5494-5503	NN	denotes	chromatin
T9326	5504-5513	NN	denotes	structure
T9327	5513-5515	,	denotes	,
T9328	5515-5517	PRP	denotes	it
T9329	5518-5522	MD	denotes	will
T9330	5526-5528	IN	denotes	of
T9331	5529-5537	NN	denotes	interest
T9332	5538-5540	TO	denotes	to
T9333	5541-5550	VB	denotes	determine
T9334	5551-5558	IN	denotes	whether
T9335	5564-5566	VBZ	denotes	is
T9336	5559-5563	NN	denotes	Atrx
T9337	5567-5573	PRP	denotes	itself
T9338	5574-5575	DT	denotes	a
T9339	5576-5585	NN	denotes	regulator
T9340	5586-5588	IN	denotes	of
T9341	5589-5594	NN	denotes	Hand1
T9342	5595-5605	NN	denotes	expression
T9343	5605-5607	,	denotes	,
T9344	5607-5609	CC	denotes	or
T9345	5610-5623	RB	denotes	alternatively
T9346	5635-5639	VBZ	denotes	acts
T9347	5624-5631	IN	denotes	whether
T9348	5632-5634	PRP	denotes	it
T9349	5640-5642	IN	denotes	as
T9350	5643-5644	DT	denotes	a
T9351	5645-5657	NN	denotes	co-regulator
T9352	5658-5660	IN	denotes	of
T9353	5661-5664	CD	denotes	one
T9354	5665-5667	CC	denotes	or
T9355	5668-5672	JJR	denotes	more
T9356	5673-5675	IN	denotes	of
T9357	5676-5679	DT	denotes	the
T9358	5707-5714	NNS	denotes	targets
T9359	5680-5690	JJ	denotes	downstream
T9360	5691-5706	JJ	denotes	transcriptional
T9361	5715-5717	IN	denotes	of
T9362	5718-5723	NN	denotes	Hand1
T9363	5723-5724	.	denotes	.
T9364	5724-5857	sentence	denotes	It is noteworthy that, in the brain-specific Atrx knockout mice, the defect was observed in terminally differentiating neurons [20].
T9365	5725-5727	PRP	denotes	It
T9366	5728-5730	VBZ	denotes	is
T9367	5731-5741	JJ	denotes	noteworthy
T9368	5742-5746	IN	denotes	that
T9369	5805-5813	VBN	denotes	observed
T9370	5746-5748	,	denotes	,
T9371	5748-5750	IN	denotes	in
T9372	5751-5754	DT	denotes	the
T9373	5784-5788	NNS	denotes	mice
T9374	5755-5760	NN	denotes	brain
T9375	5761-5769	JJ	denotes	specific
T9376	5760-5761	HYPH	denotes	-
T9377	5770-5774	NN	denotes	Atrx
T9378	5775-5783	NN	denotes	knockout
T9379	5788-5790	,	denotes	,
T9380	5790-5793	DT	denotes	the
T9381	5794-5800	NN	denotes	defect
T9382	5801-5804	VBD	denotes	was
T9383	5814-5816	IN	denotes	in
T9384	5817-5827	RB	denotes	terminally
T9385	5828-5843	VBG	denotes	differentiating
T9386	5844-5851	NNS	denotes	neurons
T9387	5852-5853	-LRB-	denotes	[
T9388	5853-5855	CD	denotes	20
T9389	5855-5856	-RRB-	denotes	]
T9390	5856-5857	.	denotes	.
T9391	5857-6166	sentence	denotes	The secondary TGCs affected in the universal Atrx knockout reported here represent one of the first terminally differentiated tissues in the developing mouse, and this may point to the requirement for Atrx in the high-level expression of some tissue-specific genes during the final stages of differentiation.
T9392	5858-5861	DT	denotes	The
T9393	5872-5876	NNS	denotes	TGCs
T9394	5862-5871	JJ	denotes	secondary
T9395	5931-5940	VBP	denotes	represent
T9396	5877-5885	VBN	denotes	affected
T9397	5886-5888	IN	denotes	in
T9398	5889-5892	DT	denotes	the
T9399	5908-5916	NN	denotes	knockout
T9400	5893-5902	JJ	denotes	universal
T9401	5903-5907	NN	denotes	Atrx
T9402	5917-5925	VBN	denotes	reported
T9403	5926-5930	RB	denotes	here
T9404	5941-5944	CD	denotes	one
T9405	5945-5947	IN	denotes	of
T9406	5948-5951	DT	denotes	the
T9407	5984-5991	NNS	denotes	tissues
T9408	5952-5957	JJ	denotes	first
T9409	5958-5968	RB	denotes	terminally
T9410	5969-5983	VBN	denotes	differentiated
T9411	5992-5994	IN	denotes	in
T9412	5995-5998	DT	denotes	the
T9413	6010-6015	NN	denotes	mouse
T9414	5999-6009	VBG	denotes	developing
T9415	6015-6017	,	denotes	,
T9416	6017-6020	CC	denotes	and
T9417	6021-6025	DT	denotes	this
T9418	6030-6035	VB	denotes	point
T9419	6026-6029	MD	denotes	may
T9420	6036-6038	IN	denotes	to
T9421	6039-6042	DT	denotes	the
T9422	6043-6054	NN	denotes	requirement
T9423	6055-6058	IN	denotes	for
T9424	6059-6063	NN	denotes	Atrx
T9425	6064-6066	IN	denotes	in
T9426	6067-6070	DT	denotes	the
T9427	6082-6092	NN	denotes	expression
T9428	6071-6075	JJ	denotes	high
T9429	6076-6081	NN	denotes	level
T9430	6075-6076	HYPH	denotes	-
T9431	6093-6095	IN	denotes	of
T9432	6096-6100	DT	denotes	some
T9433	6117-6122	NNS	denotes	genes
T9434	6101-6107	NN	denotes	tissue
T9435	6108-6116	JJ	denotes	specific
T9436	6107-6108	HYPH	denotes	-
T9437	6123-6129	IN	denotes	during
T9438	6130-6133	DT	denotes	the
T9439	6140-6146	NNS	denotes	stages
T9440	6134-6139	JJ	denotes	final
T9441	6147-6149	IN	denotes	of
T9442	6150-6165	NN	denotes	differentiation
T9443	6165-6166	.	denotes	.
T9444	6166-6374	sentence	denotes	Interestingly, the α-globin genes, the only confirmed transcriptional targets of regulation by human ATRX, are also highly expressed specifically during terminal differentiation within the erythroid lineage.
T9445	6167-6180	RB	denotes	Interestingly
T9446	6290-6299	VBN	denotes	expressed
T9447	6180-6182	,	denotes	,
T9448	6182-6185	DT	denotes	the
T9449	6195-6200	NNS	denotes	genes
T9450	6186-6187	NN	denotes	α
T9451	6188-6194	NN	denotes	globin
T9452	6187-6188	HYPH	denotes	-
T9453	6200-6202	,	denotes	,
T9454	6202-6205	DT	denotes	the
T9455	6237-6244	NNS	denotes	targets
T9456	6206-6210	RB	denotes	only
T9457	6211-6220	VBN	denotes	confirmed
T9458	6221-6236	JJ	denotes	transcriptional
T9459	6245-6247	IN	denotes	of
T9460	6248-6258	NN	denotes	regulation
T9461	6259-6261	IN	denotes	by
T9462	6262-6267	JJ	denotes	human
T9463	6268-6272	NN	denotes	ATRX
T9464	6272-6274	,	denotes	,
T9465	6274-6277	VBP	denotes	are
T9466	6278-6282	RB	denotes	also
T9467	6283-6289	RB	denotes	highly
T9468	6300-6312	RB	denotes	specifically
T9469	6313-6319	IN	denotes	during
T9470	6320-6328	JJ	denotes	terminal
T9471	6329-6344	NN	denotes	differentiation
T9472	6345-6351	IN	denotes	within
T9473	6352-6355	DT	denotes	the
T9474	6366-6373	NN	denotes	lineage
T9475	6356-6365	JJ	denotes	erythroid
T9476	6373-6374	.	denotes	.
R4824	T8323	T8324	det	An,Role
R4825	T8325	T8324	amod	Unexpected,Role
R4826	T8326	T8324	prep	for,Role
R4827	T8327	T8326	pobj	Atrx,for
R4828	T8328	T8324	prep	in,Role
R4829	T8329	T8328	pobj	Development,in
R4830	T8330	T8329	prep	of,Development
R4831	T8331	T8332	det	the,Trophoblast
R4832	T8332	T8330	pobj	Trophoblast,of
R4833	T8333	T8332	compound	Mouse,Trophoblast
R4834	T8335	T8336	nsubj	We,show
R4835	T8337	T8338	mark	that,are
R4836	T8338	T8336	ccomp	are,show
R4837	T8339	T8340	amod	Atrxnull,mice
R4838	T8340	T8338	nsubj	mice,are
R4839	T8341	T8340	amod	male,mice
R4840	T8342	T8338	neg	not,are
R4841	T8343	T8338	acomp	viable,are
R4842	T8344	T8338	cc	and,are
R4843	T8345	T8346	nsubj	embryos,die
R4844	T8346	T8338	conj	die,are
R4845	T8347	T8346	prep	by,die
R4846	T8348	T8349	quantmod	around,9.5
R4847	T8349	T8350	nummod	9.5,dpc
R4848	T8350	T8347	pobj	dpc,by
R4849	T8351	T8336	punct	.,show
R4850	T8353	T8354	prep	Before,exhibit
R4851	T8355	T8353	pobj	death,Before
R4852	T8356	T8354	punct	", ",exhibit
R4853	T8357	T8358	amod	Atrxnull,embryos
R4854	T8358	T8354	nsubj	embryos,exhibit
R4855	T8359	T8360	det	a,index
R4856	T8360	T8354	dobj	index,exhibit
R4857	T8361	T8362	advmod	markedly,reduced
R4858	T8362	T8360	amod	reduced,index
R4859	T8363	T8360	amod	mitotic,index
R4860	T8364	T8354	punct	", ",exhibit
R4861	T8365	T8354	advcl	suggesting,exhibit
R4862	T8366	T8367	det	a,defect
R4863	T8367	T8365	dobj	defect,suggesting
R4864	T8368	T8367	amod	proliferative,defect
R4865	T8369	T8354	punct	.,exhibit
R4866	T8371	T8372	mark	Although,appears
R4867	T8372	T8379	advcl	appears,display
R4868	T8373	T8374	det	the,compartment
R4869	T8374	T8372	nsubj	compartment,appears
R4870	T8375	T8374	amod	embryonic,compartment
R4871	T8376	T8374	prep	of,compartment
R4872	T8377	T8378	det	the,conceptus
R4873	T8378	T8376	pobj	conceptus,of
R4874	T8380	T8381	advmod	initially,normal
R4875	T8381	T8372	oprd	normal,appears
R4876	T8382	T8379	punct	", ",display
R4877	T8383	T8379	prep	by,display
R4878	T8384	T8385	nummod	7.5,dpc
R4879	T8385	T8383	pobj	dpc,by
R4880	T8386	T8387	amod	Atrxnull,embryos
R4881	T8387	T8379	nsubj	embryos,display
R4882	T8388	T8379	dobj	abnormalities,display
R4883	T8389	T8388	prep	in,abnormalities
R4884	T8390	T8389	pobj	development,in
R4885	T8391	T8390	prep	of,development
R4886	T8392	T8393	det	the,trophoblast
R4887	T8393	T8391	pobj	trophoblast,of
R4888	T8394	T8388	punct	", ",abnormalities
R4889	T8395	T8388	prep	including,abnormalities
R4890	T8396	T8397	det	a,depletion
R4891	T8397	T8395	pobj	depletion,including
R4892	T8398	T8397	prep	in,depletion
R4893	T8399	T8400	det	the,population
R4894	T8400	T8398	pobj	population,in
R4895	T8401	T8400	prep	of,population
R4896	T8402	T8401	pobj	TGCs,of
R4897	T8403	T8402	acl	surrounding,TGCs
R4898	T8404	T8405	det	the,conceptus
R4899	T8405	T8403	dobj	conceptus,surrounding
R4900	T8406	T8397	cc	and,depletion
R4901	T8407	T8408	det	a,reduction
R4902	T8408	T8397	conj	reduction,depletion
R4903	T8409	T8408	prep	in,reduction
R4904	T8410	T8411	det	the,size
R4905	T8411	T8409	pobj	size,in
R4906	T8412	T8411	prep	of,size
R4907	T8413	T8414	det	the,cone
R4908	T8414	T8412	pobj	cone,of
R4909	T8415	T8414	amod	ectoplacental,cone
R4910	T8416	T8414	punct	", ",cone
R4911	T8417	T8418	dep	which,contains
R4912	T8418	T8414	relcl	contains,cone
R4913	T8419	T8420	det	the,precursors
R4914	T8420	T8418	dobj	precursors,contains
R4915	T8421	T8420	nmod	diploid,precursors
R4916	T8422	T8420	amod	giant,precursors
R4917	T8423	T8420	compound	cell,precursors
R4918	T8424	T8425	punct	[,22
R4919	T8425	T8379	parataxis	22,display
R4920	T8426	T8425	punct	],22
R4921	T8427	T8379	punct	.,display
R4922	T8429	T8430	nsubj	TGCs,are
R4923	T8431	T8432	advmod	highly,differentiated
R4924	T8432	T8433	amod	differentiated,cells
R4925	T8433	T8430	attr	cells,are
R4926	T8434	T8433	punct	", ",cells
R4927	T8435	T8433	amod	postmitotic,cells
R4928	T8436	T8437	dep	that,form
R4929	T8437	T8433	relcl	form,cells
R4930	T8438	T8437	advmod	ultimately,form
R4931	T8439	T8440	det	an,layer
R4932	T8440	T8437	dobj	layer,form
R4933	T8441	T8440	amod	epithelial,layer
R4934	T8442	T8437	prep	at,form
R4935	T8443	T8444	det	the,periphery
R4936	T8444	T8442	pobj	periphery,at
R4937	T8445	T8444	prep	of,periphery
R4938	T8446	T8447	det	the,placenta
R4939	T8447	T8445	pobj	placenta,of
R4940	T8448	T8437	punct	", ",form
R4941	T8449	T8450	dep	which,interfaces
R4942	T8450	T8437	ccomp	interfaces,form
R4943	T8451	T8450	prep	with,interfaces
R4944	T8452	T8453	det	the,cells
R4945	T8453	T8451	pobj	cells,with
R4946	T8454	T8453	amod	maternal,cells
R4947	T8455	T8453	prep	of,cells
R4948	T8456	T8457	det	the,decidua
R4949	T8457	T8455	pobj	decidua,of
R4950	T8458	T8459	punct	[,23
R4951	T8459	T8430	parataxis	23,are
R4952	T8460	T8459	punct	],23
R4953	T8461	T8430	punct	.,are
R4954	T8463	T8464	det	These,cells
R4955	T8464	T8467	nsubj	cells,are
R4956	T8465	T8466	advmod	highly,invasive
R4957	T8466	T8464	amod	invasive,cells
R4958	T8468	T8467	acomp	important,are
R4959	T8469	T8468	prep	for,important
R4960	T8470	T8469	pcomp	mediating,for
R4961	T8471	T8472	amod	initial,invasion
R4962	T8472	T8470	dobj	invasion,mediating
R4963	T8473	T8472	prep	of,invasion
R4964	T8474	T8475	det	the,tissue
R4965	T8475	T8473	pobj	tissue,of
R4966	T8476	T8475	amod	uterine,tissue
R4967	T8477	T8467	punct	", ",are
R4968	T8478	T8467	cc	but,are
R4969	T8479	T8480	auxpass	are,involved
R4970	T8480	T8467	conj	involved,are
R4971	T8481	T8480	advmod	also,involved
R4972	T8482	T8480	prep	in,involved
R4973	T8483	T8482	pcomp	remodelling,in
R4974	T8484	T8485	det	the,decidua
R4975	T8485	T8483	dobj	decidua,remodelling
R4976	T8486	T8485	amod	maternal,decidua
R4977	T8487	T8483	prep	after,remodelling
R4978	T8488	T8487	pobj	implantation,after
R4979	T8489	T8482	cc	and,in
R4980	T8490	T8482	conj	in,in
R4981	T8491	T8490	pcomp	secreting,in
R4982	T8492	T8491	dobj	hormones,secreting
R4983	T8493	T8494	dep	that,regulate
R4984	T8494	T8492	relcl	regulate,hormones
R4985	T8495	T8496	amod	fetal,growth
R4986	T8496	T8494	dobj	growth,regulate
R4987	T8497	T8495	cc	and,fetal
R4988	T8498	T8495	conj	maternal,fetal
R4989	T8499	T8500	punct	[,24
R4990	T8500	T8480	parataxis	24,involved
R4991	T8501	T8500	punct	],24
R4992	T8502	T8467	punct	.,are
R4993	T8504	T8505	mark	Since,appear
R4994	T8505	T8508	advcl	appear,is
R4995	T8506	T8507	amod	Atrxnull,embryos
R4996	T8507	T8505	nsubj	embryos,appear
R4997	T8509	T8510	aux	to,implant
R4998	T8510	T8505	xcomp	implant,appear
R4999	T8511	T8510	advmod	normally,implant
R5000	T8512	T8508	punct	", ",is
R5001	T8513	T8508	nsubj	lethality,is
R5002	T8514	T8508	acomp	likely,is
R5003	T8515	T8516	aux	to,arise
R5004	T8516	T8514	xcomp	arise,likely
R5005	T8517	T8516	prep	due,arise
R5006	T8518	T8517	pcomp	to,due
R5007	T8519	T8520	det	a,failure
R5008	T8520	T8517	pobj	failure,due
R5009	T8521	T8520	prep	of,failure
R5010	T8522	T8523	compound	TGC,function
R5011	T8523	T8521	pobj	function,of
R5012	T8524	T8516	advmod	later,arise
R5013	T8525	T8516	prep	during,arise
R5014	T8526	T8525	pobj	development,during
R5015	T8527	T8508	punct	.,is
R5016	T8529	T8530	amod	Embryonic,lethality
R5017	T8530	T8531	nsubj	lethality,was
R5018	T8532	T8530	prep	in,lethality
R5019	T8533	T8532	pobj	mice,in
R5020	T8534	T8530	prep	in,lethality
R5021	T8535	T8536	det	the,absence
R5022	T8536	T8534	pobj	absence,in
R5023	T8537	T8536	prep	of,absence
R5024	T8538	T8537	pobj	Atrx,of
R5025	T8539	T8540	det	a,finding
R5026	T8540	T8531	attr	finding,was
R5027	T8541	T8540	amod	surprising,finding
R5028	T8542	T8531	punct	", ",was
R5029	T8543	T8544	mark	as,been
R5030	T8544	T8531	advcl	been,was
R5031	T8545	T8544	expl	there,been
R5032	T8546	T8544	aux	had,been
R5033	T8547	T8548	det	no,suggestion
R5034	T8548	T8544	attr	suggestion,been
R5035	T8549	T8548	prep	of,suggestion
R5036	T8550	T8551	amod	foetal,loss
R5037	T8551	T8549	pobj	loss,of
R5038	T8552	T8544	prep	in,been
R5039	T8553	T8554	det	the,syndrome
R5040	T8554	T8552	pobj	syndrome,in
R5041	T8555	T8554	amod	human,syndrome
R5042	T8556	T8557	compound	ATR,X
R5043	T8557	T8554	compound	X,syndrome
R5044	T8558	T8557	punct	-,X
R5045	T8559	T8531	punct	.,was
R5046	T8561	T8562	nsubj	It,is
R5047	T8563	T8562	acomp	possible,is
R5048	T8564	T8565	mark	that,is
R5049	T8565	T8562	advcl	is,is
R5050	T8566	T8567	det	the,role
R5051	T8567	T8565	nsubj	role,is
R5052	T8568	T8567	prep	of,role
R5053	T8569	T8568	pobj	Atrx,of
R5054	T8570	T8567	prep	in,role
R5055	T8571	T8572	det	the,trophoblast
R5056	T8572	T8570	pobj	trophoblast,in
R5057	T8573	T8565	acomp	specific,is
R5058	T8574	T8573	prep	to,specific
R5059	T8575	T8574	pobj	mice,to
R5060	T8576	T8565	cc	and,is
R5061	T8577	T8578	mark	that,has
R5062	T8578	T8565	conj	has,is
R5063	T8579	T8578	nsubj	ATRX,has
R5064	T8580	T8581	det	no,role
R5065	T8581	T8578	dobj	role,has
R5066	T8582	T8578	cc	or,has
R5067	T8583	T8578	conj	is,has
R5068	T8584	T8583	acomp	redundant,is
R5069	T8585	T8578	prep	in,has
R5070	T8586	T8587	det	the,trophoblast
R5071	T8587	T8585	pobj	trophoblast,in
R5072	T8588	T8587	amod	human,trophoblast
R5073	T8589	T8562	punct	.,is
R5074	T8591	T8592	advmod	Indeed,is
R5075	T8593	T8592	punct	", ",is
R5076	T8594	T8595	det	the,weight
R5077	T8595	T8592	nsubj	weight,is
R5078	T8596	T8595	compound	birth,weight
R5079	T8597	T8595	prep	of,weight
R5080	T8598	T8597	pobj	babies,of
R5081	T8599	T8598	prep	with,babies
R5082	T8600	T8601	compound	ATR,X
R5083	T8601	T8603	compound	X,syndrome
R5084	T8602	T8601	punct	-,X
R5085	T8603	T8599	pobj	syndrome,with
R5086	T8604	T8592	advmod	usually,is
R5087	T8605	T8592	acomp	normal,is
R5088	T8606	T8592	punct	.,is
R5089	T8608	T8609	det	An,explanation
R5090	T8609	T8611	nsubj	explanation,is
R5091	T8610	T8609	amod	alternative,explanation
R5092	T8612	T8609	prep	for,explanation
R5093	T8613	T8614	det	the,phenotype
R5094	T8614	T8612	pobj	phenotype,for
R5095	T8615	T8616	advmod	unexpectedly,severe
R5096	T8616	T8614	amod	severe,phenotype
R5097	T8617	T8618	nsubj	we,observed
R5098	T8618	T8614	advcl	observed,phenotype
R5099	T8619	T8618	prep	in,observed
R5100	T8620	T8619	pobj	mice,in
R5101	T8621	T8622	mark	that,ablates
R5102	T8622	T8611	ccomp	ablates,is
R5103	T8623	T8624	det	the,deletion
R5104	T8624	T8622	nsubj	deletion,ablates
R5105	T8625	T8624	compound	Atrx Δ18Δneo,deletion
R5106	T8626	T8624	acl	generated,deletion
R5107	T8627	T8626	prep	by,generated
R5108	T8628	T8629	compound	Cre,recombination
R5109	T8629	T8627	pobj	recombination,by
R5110	T8630	T8622	advmod	completely,ablates
R5111	T8631	T8632	amod	full,length
R5112	T8632	T8634	compound	length,protein
R5113	T8633	T8632	punct	-,length
R5114	T8634	T8622	dobj	protein,ablates
R5115	T8635	T8634	compound	Atrx,protein
R5116	T8636	T8637	punct	(,2E
R5117	T8637	T8611	parataxis	2E,is
R5118	T8638	T8637	compound	Figure,2E
R5119	T8639	T8637	punct	),2E
R5120	T8640	T8611	punct	.,is
R5121	T8642	T8643	prep	In,appear
R5122	T8644	T8642	pobj	contrast,In
R5123	T8645	T8643	punct	", ",appear
R5124	T8646	T8647	det	all,mutations
R5125	T8647	T8643	nsubj	mutations,appear
R5126	T8648	T8649	npadvmod	disease,causing
R5127	T8649	T8647	amod	causing,mutations
R5128	T8650	T8649	punct	-,causing
R5129	T8651	T8647	acl	characterised,mutations
R5130	T8652	T8651	prep	in,characterised
R5131	T8653	T8654	amod	human,pedigrees
R5132	T8654	T8652	pobj	pedigrees,in
R5133	T8655	T8656	compound	ATR,X
R5134	T8656	T8654	compound	X,pedigrees
R5135	T8657	T8656	punct	-,X
R5136	T8658	T8659	aux	to,give
R5137	T8659	T8643	xcomp	give,appear
R5138	T8660	T8659	dobj	rise,give
R5139	T8661	T8659	prep	to,give
R5140	T8662	T8663	amod	hypomorphic,alleles
R5141	T8663	T8661	pobj	alleles,to
R5142	T8664	T8643	punct	.,appear
R5143	T8666	T8667	det	Some,protein
R5144	T8667	T8672	nsubjpass	protein,detected
R5145	T8668	T8669	amod	full,length
R5146	T8669	T8667	compound	length,protein
R5147	T8670	T8669	punct	-,length
R5148	T8671	T8667	compound	ATRX,protein
R5149	T8673	T8672	auxpass	is,detected
R5150	T8674	T8672	prep	in,detected
R5151	T8675	T8674	pobj	cases,in
R5152	T8676	T8675	acl	predicted,cases
R5153	T8677	T8678	aux	to,have
R5154	T8678	T8676	xcomp	have,predicted
R5155	T8679	T8680	compound	truncating,mutations
R5156	T8680	T8678	dobj	mutations,have
R5157	T8681	T8682	punct	(,data
R5158	T8682	T8672	parataxis	data,detected
R5159	T8683	T8682	dep	RJG,data
R5160	T8684	T8682	punct	", ",data
R5161	T8685	T8682	amod	unpublished,data
R5162	T8686	T8682	punct	),data
R5163	T8687	T8672	punct	", ",detected
R5164	T8688	T8672	cc	and,detected
R5165	T8689	T8690	amod	residual,activity
R5166	T8690	T8692	nsubjpass	activity,detected
R5167	T8691	T8690	compound	ATPase,activity
R5168	T8692	T8672	conj	detected,detected
R5169	T8693	T8690	prep	in,activity
R5170	T8694	T8695	compound	ATRX,immunoprecipitates
R5171	T8695	T8693	pobj	immunoprecipitates,in
R5172	T8696	T8692	aux	can,detected
R5173	T8697	T8692	auxpass	be,detected
R5174	T8698	T8692	prep	in,detected
R5175	T8699	T8700	compound	Epstein,Barr
R5176	T8700	T8702	compound	Barr,virus
R5177	T8701	T8700	punct	-,Barr
R5178	T8702	T8703	npadvmod	virus,transformed
R5179	T8703	T8705	amod	transformed,lymphocytes
R5180	T8704	T8703	punct	-,transformed
R5181	T8705	T8698	pobj	lymphocytes,in
R5182	T8706	T8705	prep	of,lymphocytes
R5183	T8707	T8708	det	all,patients
R5184	T8708	T8706	pobj	patients,of
R5185	T8709	T8708	amod	human,patients
R5186	T8710	T8708	acl	analysed,patients
R5187	T8711	T8710	prep	to,analysed
R5188	T8712	T8711	pobj	date,to
R5189	T8713	T8714	punct	(,A.
R5190	T8714	T8692	meta	A.,detected
R5191	T8715	T8714	nmod	Argentaro,A.
R5192	T8716	T8714	cc	and,A.
R5193	T8717	T8714	conj	M.,A.
R5194	T8718	T8717	nmod	Mitson,M.
R5195	T8719	T8717	punct	", ",M.
R5196	T8720	T8721	amod	unpublished,data
R5197	T8721	T8717	conj	data,M.
R5198	T8722	T8721	punct	),data
R5199	T8723	T8692	punct	.,detected
R5200	T8725	T8726	det	The,failure
R5201	T8726	T8727	nsubj	failure,suggests
R5202	T8728	T8729	aux	to,observe
R5203	T8729	T8726	acl	observe,failure
R5204	T8730	T8731	det	a,allele
R5205	T8731	T8729	dobj	allele,observe
R5206	T8732	T8733	advmod	truly,null
R5207	T8733	T8731	amod	null,allele
R5208	T8734	T8731	compound	ATRX,allele
R5209	T8735	T8729	prep	among,observe
R5210	T8736	T8737	amod	human,patients
R5211	T8737	T8735	pobj	patients,among
R5212	T8738	T8727	advmod	strongly,suggests
R5213	T8739	T8740	mark	that,is
R5214	T8740	T8727	ccomp	is,suggests
R5215	T8741	T8740	punct	", ",is
R5216	T8742	T8740	prep	as,is
R5217	T8743	T8742	prep	in,as
R5218	T8744	T8745	det	the,mouse
R5219	T8745	T8743	pobj	mouse,in
R5220	T8746	T8740	punct	", ",is
R5221	T8747	T8748	det	the,absence
R5222	T8748	T8740	nsubj	absence,is
R5223	T8749	T8748	amod	complete,absence
R5224	T8750	T8748	prep	of,absence
R5225	T8751	T8752	compound	ATRX,protein
R5226	T8752	T8750	pobj	protein,of
R5227	T8753	T8740	acomp	incompatible,is
R5228	T8754	T8753	prep	with,incompatible
R5229	T8755	T8756	amod	human,survival
R5230	T8756	T8754	pobj	survival,with
R5231	T8757	T8756	amod	fetal,survival
R5232	T8758	T8727	punct	.,suggests
R5233	T8760	T8761	mark	While,revealed
R5234	T8761	T8765	advcl	revealed,is
R5235	T8762	T8763	det	this,study
R5236	T8763	T8761	nsubj	study,revealed
R5237	T8764	T8761	aux	has,revealed
R5238	T8766	T8767	det	an,role
R5239	T8767	T8761	dobj	role,revealed
R5240	T8768	T8767	amod	unexpected,role
R5241	T8769	T8767	prep	for,role
R5242	T8770	T8769	pobj	Atrx,for
R5243	T8771	T8767	prep	in,role
R5244	T8772	T8773	det	the,trophectoderm
R5245	T8773	T8771	pobj	trophectoderm,in
R5246	T8774	T8773	amod	murine,trophectoderm
R5247	T8775	T8761	punct	", ",revealed
R5248	T8776	T8761	prep	as,revealed
R5249	T8777	T8778	det	a,result
R5250	T8778	T8776	pobj	result,as
R5251	T8779	T8778	prep	of,result
R5252	T8780	T8781	det	the,lethality
R5253	T8781	T8779	pobj	lethality,of
R5254	T8782	T8781	amod	early,lethality
R5255	T8783	T8781	acl	observed,lethality
R5256	T8784	T8783	prep	in,observed
R5257	T8785	T8786	amod	Atrxnull,embryos
R5258	T8786	T8784	pobj	embryos,in
R5259	T8787	T8765	nsubj	it,is
R5260	T8788	T8765	neg	not,is
R5261	T8789	T8765	acomp	possible,is
R5262	T8790	T8791	aux	to,rule
R5263	T8791	T8765	xcomp	rule,is
R5264	T8792	T8791	prt	out,rule
R5265	T8793	T8794	amod	other,roles
R5266	T8794	T8791	dobj	roles,rule
R5267	T8795	T8794	prep	for,roles
R5268	T8796	T8795	pobj	Atrx,for
R5269	T8797	T8794	prep	at,roles
R5270	T8798	T8799	amod	later,stages
R5271	T8799	T8797	pobj	stages,at
R5272	T8800	T8799	amod	developmental,stages
R5273	T8801	T8794	prep	in,roles
R5274	T8802	T8801	pobj	tissues,in
R5275	T8803	T8802	prep	of,tissues
R5276	T8804	T8805	det	the,embryo
R5277	T8805	T8803	pobj	embryo,of
R5278	T8806	T8805	amod	proper,embryo
R5279	T8807	T8765	punct	.,is
R5280	T8809	T8810	advmod	Indeed,show
R5281	T8811	T8810	punct	", ",show
R5282	T8812	T8810	nsubj	we,show
R5283	T8813	T8814	mark	that,is
R5284	T8814	T8810	ccomp	is,show
R5285	T8815	T8814	nsubj	Atrx,is
R5286	T8816	T8817	advmod	highly,expressed
R5287	T8817	T8814	acomp	expressed,is
R5288	T8818	T8814	prep	throughout,is
R5289	T8819	T8820	det	the,embryo
R5290	T8820	T8818	pobj	embryo,throughout
R5291	T8821	T8820	amod	entire,embryo
R5292	T8822	T8820	amod	developing,embryo
R5293	T8823	T8814	prep	at,is
R5294	T8824	T8825	nummod	7.5,dpc
R5295	T8825	T8823	pobj	dpc,at
R5296	T8826	T8827	punct	(,5B
R5297	T8827	T8814	parataxis	5B,is
R5298	T8828	T8827	compound	Figure,5B
R5299	T8829	T8827	punct	),5B
R5300	T8830	T8810	punct	", ",show
R5301	T8831	T8810	cc	and,show
R5302	T8832	T8833	nsubj	it,is
R5303	T8833	T8810	conj	is,show
R5304	T8834	T8833	acomp	likely,is
R5305	T8835	T8836	mark	that,turn
R5306	T8836	T8833	ccomp	turn,is
R5307	T8837	T8838	compound	Atrx,function
R5308	T8838	T8836	nsubj	function,turn
R5309	T8839	T8836	aux	will,turn
R5310	T8840	T8836	prt	out,turn
R5311	T8841	T8842	aux	to,be
R5312	T8842	T8836	xcomp	be,turn
R5313	T8843	T8842	acomp	important,be
R5314	T8844	T8843	prep	for,important
R5315	T8845	T8846	amod	other,tissues
R5316	T8846	T8844	pobj	tissues,for
R5317	T8847	T8846	amod	differentiating,tissues
R5318	T8848	T8810	punct	.,show
R5319	T8850	T8851	compound	Tetraploid,aggregation
R5320	T8851	T8852	compound	aggregation,experiments
R5321	T8852	T8853	nsubj	experiments,shed
R5322	T8854	T8852	punct	(,experiments
R5323	T8855	T8856	prep	in,rescued
R5324	T8856	T8852	relcl	rescued,experiments
R5325	T8857	T8855	pobj	which,in
R5326	T8858	T8859	compound	mutant,embryos
R5327	T8859	T8856	nsubjpass	embryos,rescued
R5328	T8860	T8856	auxpass	are,rescued
R5329	T8861	T8856	prep	with,rescued
R5330	T8862	T8863	amod	wild,type
R5331	T8863	T8865	nmod	type,tissues
R5332	T8864	T8863	punct	-,type
R5333	T8865	T8861	pobj	tissues,with
R5334	T8866	T8865	amod	extraembryonic,tissues
R5335	T8867	T8853	punct	),shed
R5336	T8868	T8853	aux	might,shed
R5337	T8869	T8870	amod	more,light
R5338	T8870	T8853	dobj	light,shed
R5339	T8871	T8853	prep	on,shed
R5340	T8872	T8873	det	the,role
R5341	T8873	T8871	pobj	role,on
R5342	T8874	T8873	prep	of,role
R5343	T8875	T8874	pobj	Atrx,of
R5344	T8876	T8873	prep	during,role
R5345	T8877	T8878	amod	later,development
R5346	T8878	T8876	pobj	development,during
R5347	T8879	T8878	compound	mouse,development
R5348	T8880	T8853	punct	", ",shed
R5349	T8881	T8853	cc	but,shed
R5350	T8882	T8883	det	these,issues
R5351	T8883	T8884	nsubjpass	issues,dissected
R5352	T8884	T8853	conj	dissected,shed
R5353	T8885	T8884	aux	can,dissected
R5354	T8886	T8884	auxpass	be,dissected
R5355	T8887	T8888	advmod	more,subtly
R5356	T8888	T8884	advmod	subtly,dissected
R5357	T8889	T8884	prep	by,dissected
R5358	T8890	T8889	pcomp	combining,by
R5359	T8891	T8892	det	the,allele
R5360	T8892	T8890	dobj	allele,combining
R5361	T8893	T8892	amod	conditional,allele
R5362	T8894	T8892	compound	Atrx flox,allele
R5363	T8895	T8896	dep	that,generated
R5364	T8896	T8892	relcl	generated,allele
R5365	T8897	T8896	nsubj	we,generated
R5366	T8898	T8896	aux	have,generated
R5367	T8899	T8890	prep	with,combining
R5368	T8900	T8901	amod	different,transgenes
R5369	T8901	T8899	pobj	transgenes,with
R5370	T8902	T8903	npadvmod	tissue,specific
R5371	T8903	T8901	amod	specific,transgenes
R5372	T8904	T8903	punct	-,specific
R5373	T8905	T8901	compound	Cre,transgenes
R5374	T8906	T8884	punct	.,dissected
R5375	T8908	T8909	mark	As,mentioned
R5376	T8909	T8910	advcl	mentioned,revealed
R5377	T8911	T8909	advmod	above,mentioned
R5378	T8912	T8910	punct	", ",revealed
R5379	T8913	T8914	det	this,approach
R5380	T8914	T8910	nsubj	approach,revealed
R5381	T8915	T8910	aux	has,revealed
R5382	T8916	T8910	advmod	already,revealed
R5383	T8917	T8918	det	a,role
R5384	T8918	T8910	dobj	role,revealed
R5385	T8919	T8918	amod	critical,role
R5386	T8920	T8918	prep	for,role
R5387	T8921	T8920	pobj	Atrx,for
R5388	T8922	T8918	prep	during,role
R5389	T8923	T8924	amod	neuronal,differentiation
R5390	T8924	T8922	pobj	differentiation,during
R5391	T8925	T8918	prep	in,role
R5392	T8926	T8927	amod	adult,mice
R5393	T8927	T8925	pobj	mice,in
R5394	T8928	T8929	punct	[,20
R5395	T8929	T8910	parataxis	20,revealed
R5396	T8930	T8929	punct	],20
R5397	T8931	T8910	punct	.,revealed
R5398	T8933	T8934	amod	Further,evidence
R5399	T8934	T8935	nsubjpass	evidence,provided
R5400	T8936	T8937	mark	that,required
R5401	T8937	T8934	acl	required,evidence
R5402	T8938	T8937	nsubjpass	Atrx,required
R5403	T8939	T8937	auxpass	is,required
R5404	T8940	T8937	advmod	also,required
R5405	T8941	T8937	prep	at,required
R5406	T8942	T8943	amod	later,stages
R5407	T8943	T8941	pobj	stages,at
R5408	T8944	T8943	prep	of,stages
R5409	T8945	T8946	compound	mouse,development
R5410	T8946	T8944	pobj	development,of
R5411	T8947	T8935	auxpass	is,provided
R5412	T8948	T8935	agent	by,provided
R5413	T8949	T8950	det	the,skewing
R5414	T8950	T8948	pobj	skewing,by
R5415	T8951	T8950	amod	observed,skewing
R5416	T8952	T8950	amod	dramatic,skewing
R5417	T8953	T8950	prep	against,skewing
R5418	T8954	T8955	nmod	Atrx,cells
R5419	T8955	T8953	pobj	cells,against
R5420	T8956	T8954	punct	-,Atrx
R5421	T8957	T8954	amod	negative,Atrx
R5422	T8958	T8950	prep	in,skewing
R5423	T8959	T8960	det	some,tissues
R5424	T8960	T8958	pobj	tissues,in
R5425	T8961	T8960	amod	somatic,tissues
R5426	T8962	T8960	prep	of,tissues
R5427	T8963	T8964	nmod	carrier,mice
R5428	T8964	T8962	pobj	mice,of
R5429	T8965	T8964	amod	female,mice
R5430	T8966	T8964	punct	", ",mice
R5431	T8967	T8968	poss	whose,tissues
R5432	T8968	T8969	dep	tissues,comprise
R5433	T8969	T8964	relcl	comprise,mice
R5434	T8970	T8969	advmod	initially,comprise
R5435	T8971	T8972	det	a,mosaic
R5436	T8972	T8969	dobj	mosaic,comprise
R5437	T8973	T8972	prep	of,mosaic
R5438	T8974	T8975	npadvmod	Atrx,positive
R5439	T8975	T8977	amod	positive,cells
R5440	T8976	T8975	punct	-,positive
R5441	T8977	T8973	pobj	cells,of
R5442	T8978	T8975	cc	and,positive
R5443	T8979	T8980	npadvmod	Atrx,negative
R5444	T8980	T8975	conj	negative,positive
R5445	T8981	T8980	punct	-,negative
R5446	T8982	T8969	prep	as,comprise
R5447	T8983	T8984	det	a,result
R5448	T8984	T8982	pobj	result,as
R5449	T8985	T8984	prep	of,result
R5450	T8986	T8987	amod	random,inactivation
R5451	T8987	T8985	pobj	inactivation,of
R5452	T8988	T8987	compound	X,inactivation
R5453	T8989	T8987	punct	-,inactivation
R5454	T8990	T8991	punct	(,M.
R5455	T8991	T8935	meta	M.,provided
R5456	T8992	T8991	nmod	Muers,M.
R5457	T8993	T8991	punct	", ",M.
R5458	T8994	T8991	amod	personal,M.
R5459	T8995	T8991	nmod	communication,M.
R5460	T8996	T8991	punct	),M.
R5461	T8997	T8935	punct	.,provided
R5462	T8999	T9000	nsubj	Atrx,joins
R5463	T9001	T9002	det	an,list
R5464	T9002	T9000	dobj	list,joins
R5465	T9003	T9002	amod	expanding,list
R5466	T9004	T9002	prep	of,list
R5467	T9005	T9006	compound	mouse,genes
R5468	T9006	T9004	pobj	genes,of
R5469	T9007	T9008	prep	for,results
R5470	T9008	T9002	relcl	results,list
R5471	T9009	T9007	pobj	which,for
R5472	T9010	T9011	amod	targeted,disruption
R5473	T9011	T9008	nsubj	disruption,results
R5474	T9012	T9008	prep	in,results
R5475	T9013	T9014	amod	peri-implantation,lethality
R5476	T9014	T9012	pobj	lethality,in
R5477	T9015	T9008	prep	as,results
R5478	T9016	T9017	det	a,result
R5479	T9017	T9015	pobj	result,as
R5480	T9018	T9017	prep	of,result
R5481	T9019	T9020	nmod	trophoblast,abnormalities
R5482	T9020	T9018	pobj	abnormalities,of
R5483	T9021	T9019	cc	or,trophoblast
R5484	T9022	T9019	conj	placental,trophoblast
R5485	T9023	T9024	punct	(,reviewed
R5486	T9024	T9000	parataxis	reviewed,joins
R5487	T9025	T9024	prep	in,reviewed
R5488	T9026	T9025	punct	[,in
R5489	T9027	T9025	pobj	25,in
R5490	T9028	T9024	punct	],reviewed
R5491	T9029	T9024	punct	),reviewed
R5492	T9030	T9000	punct	.,joins
R5493	T9032	T9033	nsubj	Comparison,provide
R5494	T9034	T9032	prep	with,Comparison
R5495	T9035	T9036	amod	other,phenotypes
R5496	T9036	T9034	pobj	phenotypes,with
R5497	T9037	T9033	aux	might,provide
R5498	T9038	T9039	det	some,insight
R5499	T9039	T9033	dobj	insight,provide
R5500	T9040	T9033	prep	into,provide
R5501	T9041	T9042	det	the,role
R5502	T9042	T9040	pobj	role,into
R5503	T9043	T9042	prep	of,role
R5504	T9044	T9043	pobj	Atrx,of
R5505	T9045	T9042	prep	in,role
R5506	T9046	T9047	compound	trophoblast,development
R5507	T9047	T9045	pobj	development,in
R5508	T9048	T9033	punct	.,provide
R5509	T9050	T9051	compound	Atrx,mutant
R5510	T9051	T9053	compound	mutant,embryos
R5511	T9052	T9051	punct	-,mutant
R5512	T9053	T9054	nsubj	embryos,progress
R5513	T9055	T9054	advmod	further,progress
R5514	T9056	T9055	prep	than,further
R5515	T9057	T9056	pobj	embryos,than
R5516	T9058	T9057	amod	nullizygous,embryos
R5517	T9059	T9058	prep	for,nullizygous
R5518	T9060	T9059	pobj	factors,for
R5519	T9061	T9060	acl	involved,factors
R5520	T9062	T9061	prep	in,involved
R5521	T9063	T9064	det	the,specification
R5522	T9064	T9062	pobj	specification,in
R5523	T9065	T9064	amod	initial,specification
R5524	T9066	T9064	prep	of,specification
R5525	T9067	T9068	compound	trophoblast,cells
R5526	T9068	T9066	pobj	cells,of
R5527	T9069	T9068	compound	stem,cells
R5528	T9070	T9071	punct	(,as
R5529	T9071	T9064	parataxis	as,specification
R5530	T9072	T9071	amod	such,as
R5531	T9073	T9071	pobj	Cdx2,as
R5532	T9074	T9071	punct	),as
R5533	T9075	T9062	cc	or,in
R5534	T9076	T9062	conj	in,in
R5535	T9077	T9078	compound	stem,maintenance
R5536	T9078	T9076	pobj	maintenance,in
R5537	T9079	T9078	compound	cell,maintenance
R5538	T9080	T9078	cc	and,maintenance
R5539	T9081	T9078	conj	proliferation,maintenance
R5540	T9082	T9083	punct	(,as
R5541	T9083	T9078	parataxis	as,maintenance
R5542	T9084	T9083	amod	such,as
R5543	T9085	T9083	pobj	Eomes,as
R5544	T9086	T9083	punct	),as
R5545	T9087	T9054	punct	.,progress
R5546	T9089	T9090	compound	Cdx2,mutant
R5547	T9090	T9092	compound	mutant,embryos
R5548	T9091	T9090	punct	-,mutant
R5549	T9092	T9093	nsubj	embryos,fail
R5550	T9094	T9095	aux	to,implant
R5551	T9095	T9093	xcomp	implant,fail
R5552	T9096	T9093	cc	and,fail
R5553	T9097	T9093	conj	die,fail
R5554	T9098	T9099	quantmod	between,3.5
R5555	T9099	T9100	nummod	3.5,dpc
R5556	T9100	T9097	dobj	dpc,die
R5557	T9101	T9099	cc	and,3.5
R5558	T9102	T9099	conj	5.5,3.5
R5559	T9103	T9104	punct	[,26
R5560	T9104	T9093	parataxis	26,fail
R5561	T9105	T9104	punct	],26
R5562	T9106	T9093	punct	", ",fail
R5563	T9107	T9108	mark	while,implant
R5564	T9108	T9093	advcl	implant,fail
R5565	T9109	T9110	compound	Eomes,mutant
R5566	T9110	T9112	compound	mutant,blastocysts
R5567	T9111	T9110	punct	-,mutant
R5568	T9112	T9108	nsubj	blastocysts,implant
R5569	T9113	T9108	prep	into,implant
R5570	T9114	T9115	det	the,uterus
R5571	T9115	T9113	pobj	uterus,into
R5572	T9116	T9108	punct	", ",implant
R5573	T9117	T9108	cc	but,implant
R5574	T9118	T9108	conj	arrest,implant
R5575	T9119	T9120	advmod	soon,after
R5576	T9120	T9118	prep	after,arrest
R5577	T9121	T9120	pobj	implantation,after
R5578	T9122	T9118	prep	without,arrest
R5579	T9123	T9122	pcomp	forming,without
R5580	T9124	T9125	amod	organised,structures
R5581	T9125	T9123	dobj	structures,forming
R5582	T9126	T9125	amod	embryonic,structures
R5583	T9127	T9126	cc	or,embryonic
R5584	T9128	T9126	conj	extraembryonic,embryonic
R5585	T9129	T9130	punct	[,27
R5586	T9130	T9093	parataxis	27,fail
R5587	T9131	T9130	punct	],27
R5588	T9132	T9093	punct	.,fail
R5589	T9134	T9135	prep	In,implant
R5590	T9136	T9134	pobj	contrast,In
R5591	T9137	T9135	punct	", ",implant
R5592	T9138	T9139	compound	Atrx,mutant
R5593	T9139	T9141	compound	mutant,embryos
R5594	T9140	T9139	punct	-,mutant
R5595	T9141	T9135	nsubj	embryos,implant
R5596	T9142	T9135	advmod	successfully,implant
R5597	T9143	T9135	cc	and,implant
R5598	T9144	T9135	conj	establish,implant
R5599	T9145	T9146	amod	organised,structures
R5600	T9146	T9144	dobj	structures,establish
R5601	T9147	T9146	amod	embryonic,structures
R5602	T9148	T9144	prep	by,establish
R5603	T9149	T9150	nummod	7.5,dpc
R5604	T9150	T9148	pobj	dpc,by
R5605	T9151	T9135	punct	.,implant
R5606	T9153	T9154	det	The,phenotype
R5607	T9154	T9158	nsubj	phenotype,resembles
R5608	T9155	T9156	compound	Atrx,mutant
R5609	T9156	T9154	compound	mutant,phenotype
R5610	T9157	T9156	punct	-,mutant
R5611	T9159	T9158	advmod	closely,resembles
R5612	T9160	T9158	dobj	that,resembles
R5613	T9161	T9160	acl	observed,that
R5614	T9162	T9161	prep	in,observed
R5615	T9163	T9162	pobj	mice,in
R5616	T9164	T9163	amod	nullizygous,mice
R5617	T9165	T9164	prep	for,nullizygous
R5618	T9166	T9167	det	the,factor
R5619	T9167	T9165	pobj	factor,for
R5620	T9168	T9167	amod	basic,factor
R5621	T9169	T9170	compound	helix,helix
R5622	T9170	T9167	compound	helix,factor
R5623	T9171	T9170	punct	-,helix
R5624	T9172	T9170	compound	loop,helix
R5625	T9173	T9170	punct	-,helix
R5626	T9174	T9167	compound	transcription,factor
R5627	T9175	T9167	appos	Hand1,factor
R5628	T9176	T9158	punct	.,resembles
R5629	T9178	T9179	compound	Hand1,mutant
R5630	T9179	T9181	compound	mutant,conceptuses
R5631	T9180	T9179	punct	-,mutant
R5632	T9181	T9182	nsubj	conceptuses,arrest
R5633	T9183	T9182	prep	at,arrest
R5634	T9184	T9185	quantmod	around,7.5
R5635	T9185	T9186	nummod	7.5,dpc
R5636	T9186	T9183	pobj	dpc,at
R5637	T9187	T9182	cc	and,arrest
R5638	T9188	T9182	conj	display,arrest
R5639	T9189	T9190	det	a,compartment
R5640	T9190	T9188	dobj	compartment,display
R5641	T9191	T9190	amod	normal,compartment
R5642	T9192	T9190	amod	embryonic,compartment
R5643	T9193	T9182	punct	", ",arrest
R5644	T9194	T9182	cc	but,arrest
R5645	T9195	T9182	punct	", ",arrest
R5646	T9196	T9197	prep	like,causes
R5647	T9197	T9182	conj	causes,arrest
R5648	T9198	T9199	compound	Atrx,mutant
R5649	T9199	T9201	compound	mutant,embryos
R5650	T9200	T9199	punct	-,mutant
R5651	T9201	T9196	pobj	embryos,like
R5652	T9202	T9197	punct	", ",causes
R5653	T9203	T9197	nsubj	ablation,causes
R5654	T9204	T9203	prep	of,ablation
R5655	T9205	T9204	pobj	Hand1,of
R5656	T9206	T9207	det	a,reduction
R5657	T9207	T9197	dobj	reduction,causes
R5658	T9208	T9207	prep	in,reduction
R5659	T9209	T9210	det	the,size
R5660	T9210	T9208	pobj	size,in
R5661	T9211	T9210	prep	of,size
R5662	T9212	T9213	det	the,cone
R5663	T9213	T9211	pobj	cone,of
R5664	T9214	T9213	amod	ectoplacental,cone
R5665	T9215	T9210	cc	and,size
R5666	T9216	T9210	conj	density,size
R5667	T9217	T9216	prep	of,density
R5668	T9218	T9217	pobj	TGCs,of
R5669	T9219	T9220	punct	[,28
R5670	T9220	T9197	parataxis	28,causes
R5671	T9221	T9220	punct	],28
R5672	T9222	T9197	punct	.,causes
R5673	T9224	T9225	prep	As,recovered
R5674	T9226	T9224	prep	with,As
R5675	T9227	T9228	compound	Atrx,mutants
R5676	T9228	T9226	pobj	mutants,with
R5677	T9229	T9225	punct	", ",recovered
R5678	T9230	T9231	advmod	only,conceptuses
R5679	T9231	T9225	nsubjpass	conceptuses,recovered
R5680	T9232	T9231	amod	arrested,conceptuses
R5681	T9233	T9232	cc	or,arrested
R5682	T9234	T9232	conj	resorbed,arrested
R5683	T9235	T9236	compound	Hand1,mutant
R5684	T9236	T9231	compound	mutant,conceptuses
R5685	T9237	T9236	punct	-,mutant
R5686	T9238	T9225	auxpass	were,recovered
R5687	T9239	T9225	prep	after,recovered
R5688	T9240	T9241	nummod	8.5,dpc
R5689	T9241	T9239	pobj	dpc,after
R5690	T9242	T9225	punct	.,recovered
R5691	T9244	T9245	advmod	Also,affects
R5692	T9246	T9245	prep	like,affects
R5693	T9247	T9246	pobj	Atrx,like
R5694	T9248	T9245	punct	", ",affects
R5695	T9249	T9245	nsubj	disruption,affects
R5696	T9250	T9249	prep	of,disruption
R5697	T9251	T9250	pobj	Hand1,of
R5698	T9252	T9245	advmod	specifically,affects
R5699	T9253	T9254	amod	secondary,cell
R5700	T9254	T9256	compound	cell,formation
R5701	T9255	T9254	amod	giant,cell
R5702	T9256	T9245	dobj	formation,affects
R5703	T9257	T9245	punct	", ",affects
R5704	T9258	T9245	cc	and,affects
R5705	T9259	T9260	amod	primary,outgrowths
R5706	T9260	T9262	nsubj	outgrowths,appeared
R5707	T9261	T9260	compound	trophoblast,outgrowths
R5708	T9262	T9245	conj	appeared,affects
R5709	T9263	T9260	prep	from,outgrowths
R5710	T9264	T9263	pobj	blastocysts,from
R5711	T9265	T9262	oprd	normal,appeared
R5712	T9266	T9262	punct	.,appeared
R5713	T9268	T9269	nsubjpass	Hand1,required
R5714	T9270	T9269	auxpass	is,required
R5715	T9271	T9269	prep	for,required
R5716	T9272	T9273	amod	terminal,differentiation
R5717	T9273	T9271	pobj	differentiation,for
R5718	T9274	T9273	prep	of,differentiation
R5719	T9275	T9276	amod	secondary,TGCs
R5720	T9276	T9274	pobj	TGCs,of
R5721	T9277	T9269	punct	", ",required
R5722	T9278	T9269	cc	and,required
R5723	T9279	T9280	prep	in,arrest
R5724	T9280	T9269	conj	arrest,required
R5725	T9281	T9282	poss	its,absence
R5726	T9282	T9279	pobj	absence,in
R5727	T9283	T9284	compound	trophoblast,cells
R5728	T9284	T9280	nsubj	cells,arrest
R5729	T9285	T9280	prep	at,arrest
R5730	T9286	T9287	det	a,stage
R5731	T9287	T9285	pobj	stage,at
R5732	T9288	T9287	compound	precursor,stage
R5733	T9289	T9280	prep	in,arrest
R5734	T9290	T9291	det	the,cone
R5735	T9291	T9289	pobj	cone,in
R5736	T9292	T9291	amod	ectoplacental,cone
R5737	T9293	T9294	punct	[,28
R5738	T9294	T9280	parataxis	28,arrest
R5739	T9295	T9294	nummod	17,28
R5740	T9296	T9294	punct	",",28
R5741	T9297	T9294	punct	],28
R5742	T9298	T9280	punct	.,arrest
R5743	T9300	T9301	prep	Given,be
R5744	T9302	T9303	det	the,similarity
R5745	T9303	T9300	pobj	similarity,Given
R5746	T9304	T9303	prep	of,similarity
R5747	T9305	T9306	det	the,phenotypes
R5748	T9306	T9304	pobj	phenotypes,of
R5749	T9307	T9308	nmod	Atrx,mutant
R5750	T9308	T9306	compound	mutant,phenotypes
R5751	T9309	T9307	punct	-,Atrx
R5752	T9310	T9307	cc	and,Atrx
R5753	T9311	T9307	conj	Hand1,Atrx
R5754	T9312	T9308	punct	-,mutant
R5755	T9313	T9303	cc	and,similarity
R5756	T9314	T9315	det	the,likelihood
R5757	T9315	T9303	conj	likelihood,similarity
R5758	T9316	T9317	mark	that,acts
R5759	T9317	T9315	acl	acts,likelihood
R5760	T9318	T9317	nsubj	Atrx,acts
R5761	T9319	T9317	prep	as,acts
R5762	T9320	T9321	det	a,regulator
R5763	T9321	T9319	pobj	regulator,as
R5764	T9322	T9321	amod	transcriptional,regulator
R5765	T9323	T9317	prep	by,acts
R5766	T9324	T9323	pcomp	modifying,by
R5767	T9325	T9326	compound	chromatin,structure
R5768	T9326	T9324	dobj	structure,modifying
R5769	T9327	T9301	punct	", ",be
R5770	T9328	T9301	nsubj	it,be
R5771	T9329	T9301	aux	will,be
R5772	T9330	T9301	prep	of,be
R5773	T9331	T9330	pobj	interest,of
R5774	T9332	T9333	aux	to,determine
R5775	T9333	T9301	xcomp	determine,be
R5776	T9334	T9335	mark	whether,is
R5777	T9335	T9333	advcl	is,determine
R5778	T9336	T9335	nsubj	Atrx,is
R5779	T9337	T9335	npadvmod	itself,is
R5780	T9338	T9339	det	a,regulator
R5781	T9339	T9335	attr	regulator,is
R5782	T9340	T9339	prep	of,regulator
R5783	T9341	T9342	compound	Hand1,expression
R5784	T9342	T9340	pobj	expression,of
R5785	T9343	T9335	punct	", ",is
R5786	T9344	T9335	cc	or,is
R5787	T9345	T9346	advmod	alternatively,acts
R5788	T9346	T9335	conj	acts,is
R5789	T9347	T9346	mark	whether,acts
R5790	T9348	T9346	nsubj	it,acts
R5791	T9349	T9346	prep	as,acts
R5792	T9350	T9351	det	a,co-regulator
R5793	T9351	T9349	pobj	co-regulator,as
R5794	T9352	T9351	prep	of,co-regulator
R5795	T9353	T9352	pobj	one,of
R5796	T9354	T9353	cc	or,one
R5797	T9355	T9353	conj	more,one
R5798	T9356	T9353	prep	of,one
R5799	T9357	T9358	det	the,targets
R5800	T9358	T9356	pobj	targets,of
R5801	T9359	T9358	amod	downstream,targets
R5802	T9360	T9358	amod	transcriptional,targets
R5803	T9361	T9358	prep	of,targets
R5804	T9362	T9361	pobj	Hand1,of
R5805	T9363	T9301	punct	.,be
R5806	T9365	T9366	nsubj	It,is
R5807	T9367	T9366	acomp	noteworthy,is
R5808	T9368	T9369	mark	that,observed
R5809	T9369	T9366	ccomp	observed,is
R5810	T9370	T9369	punct	", ",observed
R5811	T9371	T9369	prep	in,observed
R5812	T9372	T9373	det	the,mice
R5813	T9373	T9371	pobj	mice,in
R5814	T9374	T9375	npadvmod	brain,specific
R5815	T9375	T9373	amod	specific,mice
R5816	T9376	T9375	punct	-,specific
R5817	T9377	T9378	compound	Atrx,knockout
R5818	T9378	T9373	compound	knockout,mice
R5819	T9379	T9369	punct	", ",observed
R5820	T9380	T9381	det	the,defect
R5821	T9381	T9369	nsubjpass	defect,observed
R5822	T9382	T9369	auxpass	was,observed
R5823	T9383	T9369	prep	in,observed
R5824	T9384	T9385	advmod	terminally,differentiating
R5825	T9385	T9386	amod	differentiating,neurons
R5826	T9386	T9383	pobj	neurons,in
R5827	T9387	T9388	punct	[,20
R5828	T9388	T9366	parataxis	20,is
R5829	T9389	T9388	punct	],20
R5830	T9390	T9366	punct	.,is
R5831	T9392	T9393	det	The,TGCs
R5832	T9393	T9395	nsubj	TGCs,represent
R5833	T9394	T9393	amod	secondary,TGCs
R5834	T9396	T9393	acl	affected,TGCs
R5835	T9397	T9396	prep	in,affected
R5836	T9398	T9399	det	the,knockout
R5837	T9399	T9397	pobj	knockout,in
R5838	T9400	T9399	amod	universal,knockout
R5839	T9401	T9399	compound	Atrx,knockout
R5840	T9402	T9399	acl	reported,knockout
R5841	T9403	T9402	advmod	here,reported
R5842	T9404	T9395	dobj	one,represent
R5843	T9405	T9404	prep	of,one
R5844	T9406	T9407	det	the,tissues
R5845	T9407	T9405	pobj	tissues,of
R5846	T9408	T9407	amod	first,tissues
R5847	T9409	T9410	advmod	terminally,differentiated
R5848	T9410	T9407	amod	differentiated,tissues
R5849	T9411	T9404	prep	in,one
R5850	T9412	T9413	det	the,mouse
R5851	T9413	T9411	pobj	mouse,in
R5852	T9414	T9413	amod	developing,mouse
R5853	T9415	T9395	punct	", ",represent
R5854	T9416	T9395	cc	and,represent
R5855	T9417	T9418	nsubj	this,point
R5856	T9418	T9395	conj	point,represent
R5857	T9419	T9418	aux	may,point
R5858	T9420	T9418	prep	to,point
R5859	T9421	T9422	det	the,requirement
R5860	T9422	T9420	pobj	requirement,to
R5861	T9423	T9422	prep	for,requirement
R5862	T9424	T9423	pobj	Atrx,for
R5863	T9425	T9422	prep	in,requirement
R5864	T9426	T9427	det	the,expression
R5865	T9427	T9425	pobj	expression,in
R5866	T9428	T9429	amod	high,level
R5867	T9429	T9427	compound	level,expression
R5868	T9430	T9429	punct	-,level
R5869	T9431	T9427	prep	of,expression
R5870	T9432	T9433	det	some,genes
R5871	T9433	T9431	pobj	genes,of
R5872	T9434	T9435	npadvmod	tissue,specific
R5873	T9435	T9433	amod	specific,genes
R5874	T9436	T9435	punct	-,specific
R5875	T9437	T9422	prep	during,requirement
R5876	T9438	T9439	det	the,stages
R5877	T9439	T9437	pobj	stages,during
R5878	T9440	T9439	amod	final,stages
R5879	T9441	T9439	prep	of,stages
R5880	T9442	T9441	pobj	differentiation,of
R5881	T9443	T9418	punct	.,point
R5882	T9445	T9446	advmod	Interestingly,expressed
R5883	T9447	T9446	punct	", ",expressed
R5884	T9448	T9449	det	the,genes
R5885	T9449	T9446	nsubjpass	genes,expressed
R5886	T9450	T9451	compound	α,globin
R5887	T9451	T9449	compound	globin,genes
R5888	T9452	T9451	punct	-,globin
R5889	T9453	T9449	punct	", ",genes
R5890	T9454	T9455	det	the,targets
R5891	T9455	T9449	appos	targets,genes
R5892	T9456	T9455	advmod	only,targets
R5893	T9457	T9455	amod	confirmed,targets
R5894	T9458	T9455	amod	transcriptional,targets
R5895	T9459	T9455	prep	of,targets
R5896	T9460	T9459	pobj	regulation,of
R5897	T9461	T9460	prep	by,regulation
R5898	T9462	T9463	amod	human,ATRX
R5899	T9463	T9461	pobj	ATRX,by
R5900	T9464	T9446	punct	", ",expressed
R5901	T9465	T9446	auxpass	are,expressed
R5902	T9466	T9446	advmod	also,expressed
R5903	T9467	T9446	advmod	highly,expressed
R5904	T9468	T9469	advmod	specifically,during
R5905	T9469	T9446	prep	during,expressed
R5906	T9470	T9471	amod	terminal,differentiation
R5907	T9471	T9469	pobj	differentiation,during
R5908	T9472	T9446	prep	within,expressed
R5909	T9473	T9474	det	the,lineage
R5910	T9474	T9472	pobj	lineage,within
R5911	T9475	T9474	amod	erythroid,lineage
R5912	T9476	T9446	punct	.,expressed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T8062	23-27	PR_EXT:000004503	denotes	Atrx
T8063	50-55	NCBITaxon:10088	denotes	Mouse
T8064	56-67	UBERON:0000088	denotes	Trophoblast
T8065	81-85	PR_EXT:000004503	denotes	Atrx
T8066	85-89	SO_EXT:sequence_nullness	denotes	null
T8067	90-94	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T8068	95-99	NCBITaxon:10088	denotes	mice
T8069	119-126	UBERON:0000922	denotes	embryos
T8070	127-130	GO:0016265	denotes	die
T8071	157-162	GO:0016265	denotes	death
T8072	164-168	PR_EXT:000004503	denotes	Atrx
T8073	168-172	SO_EXT:sequence_nullness	denotes	null
T8074	173-180	UBERON:0000922	denotes	embryos
T8075	208-215	GO:0007067	denotes	mitotic
T8076	236-249	GO_PATO_EXT:cell_proliferation_or_proliferativity	denotes	proliferative
T8077	271-280	UBERON:0000922	denotes	embryonic
T8078	300-309	UBERON:0004716	denotes	conceptus
T8079	347-351	PR_EXT:000004503	denotes	Atrx
T8080	351-355	SO_EXT:sequence_nullness	denotes	null
T8081	356-363	UBERON:0000922	denotes	embryos
T8082	408-419	UBERON:0000088	denotes	trophoblast
T8083	464-468	CL:0002488	denotes	TGCs
T8084	485-494	UBERON:0004716	denotes	conceptus
T8085	530-548	UBERON:0004364	denotes	ectoplacental cone
T8086	569-576	_FRAGMENT	denotes	diploid
T8087	583-587	CL:0000415	denotes	cell
T8088	577-587	CL:0002488	denotes	giant cell
T8089	583-587	CL_GO_EXT:cell	denotes	cell
T8090	605-609	CL:0002488	denotes	TGCs
T8091	621-635	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T8092	641-648	GO:0007067	denotes	mitotic
T8093	649-654	CL_GO_EXT:cell	denotes	cells
T8094	679-689	UBERON:0000483	denotes	epithelial
T8095	720-728	UBERON:0001987	denotes	placenta
T8096	765-770	CL_GO_EXT:cell	denotes	cells
T8097	778-785	UBERON:0002450	denotes	decidua
T8098	814-819	CL_GO_EXT:cell	denotes	cells
T8099	872-879	UBERON:0000995	denotes	uterine
T8100	880-886	UBERON:0000479	denotes	tissue
T8101	938-945	UBERON:0002450	denotes	decidua
T8102	952-964	GO:0007566	denotes	implantation
T8103	972-981	GO:0046903	denotes	secreting
T8104	982-990	CHEBI_GO_EXT:hormone	denotes	hormones
T8105	996-1004	GO:0065007	denotes	regulate
T8106	1024-1030	GO_EXT:biological_growth_entity_or_process	denotes	growth
T8107	1043-1047	PR_EXT:000004503	denotes	Atrx
T8108	1047-1051	SO_EXT:sequence_nullness	denotes	null
T8109	1052-1059	UBERON:0000922	denotes	embryos
T8110	1070-1077	GO:0007566	denotes	implant
T8111	1088-1097	GO_EXT:fatality_or_lethality	denotes	lethality
T8112	1137-1140	CL:0002488	denotes	TGC
T8113	1176-1185	UBERON:0000922	denotes	Embryonic
T8114	1186-1195	GO_EXT:fatality_or_lethality	denotes	lethality
T8115	1199-1203	NCBITaxon:10088	denotes	mice
T8116	1222-1226	PR_EXT:000004503	denotes	Atrx
T8117	1307-1312	NCBITaxon:9606	denotes	human
T8118	1317-1318	GO:0000805	denotes	X
T8119	1361-1365	PR_EXT:000004503	denotes	Atrx
T8120	1373-1384	UBERON:0000088	denotes	trophoblast
T8121	1400-1404	NCBITaxon:10088	denotes	mice
T8122	1414-1418	PR_EXT:000004503	denotes	ATRX
T8123	1454-1459	NCBITaxon:9606	denotes	human
T8124	1460-1471	UBERON:0000088	denotes	trophoblast
T8125	1485-1490	GO:0007567	denotes	birth
T8126	1501-1507	UBERON_EXT:baby_or_infant	denotes	babies
T8127	1517-1518	GO:0000805	denotes	X
T8128	1627-1631	NCBITaxon:10088	denotes	mice
T8129	1644-1648	PR_EXT:000004503	denotes	Atrx
T8130	1657-1665	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T8131	1683-1696	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8132	1728-1732	PR_EXT:000004503	denotes	Atrx
T8133	1733-1740	CHEBI_PR_EXT:protein	denotes	protein
T8134	1787-1796	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8135	1814-1819	NCBITaxon:9606	denotes	human
T8136	1824-1825	GO:0000805	denotes	X
T8137	1871-1878	SO_EXT:0001023	denotes	alleles
T8138	1897-1901	PR_EXT:000004503	denotes	ATRX
T8139	1902-1909	CHEBI_PR_EXT:protein	denotes	protein
T8140	1949-1959	SO_EXT:sequence_truncation_process	denotes	truncating
T8141	1960-1969	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8142	2008-2014	GO_EXT:0016887	denotes	ATPase
T8143	2027-2031	PR_EXT:000004503	denotes	ATRX
T8144	2070-2088	NCBITaxon:10376	denotes	Epstein-Barr virus
T8145	2089-2100	GO:0009294	denotes	transformed
T8146	2101-2112	CL:0000542	denotes	lymphocytes
T8147	2120-2125	NCBITaxon:9606	denotes	human
T8148	2231-2235	SO_EXT:sequence_nullness	denotes	null
T8149	2236-2240	PR_EXT:000004503	denotes	ATRX
T8150	2241-2247	SO_EXT:0001023	denotes	allele
T8151	2254-2259	NCBITaxon:9606	denotes	human
T8152	2303-2308	NCBITaxon:10088	denotes	mouse
T8153	2334-2338	PR_EXT:000004503	denotes	ATRX
T8154	2339-2346	CHEBI_PR_EXT:protein	denotes	protein
T8155	2368-2373	NCBITaxon:9606	denotes	human
T8156	2443-2447	PR_EXT:000004503	denotes	Atrx
T8157	2455-2461	NCBITaxon:39107	denotes	murine
T8158	2462-2475	UBERON:0004345	denotes	trophectoderm
T8159	2502-2511	GO_EXT:fatality_or_lethality	denotes	lethality
T8160	2524-2528	PR_EXT:000004503	denotes	Atrx
T8161	2528-2532	SO_EXT:sequence_nullness	denotes	null
T8162	2533-2540	UBERON:0000922	denotes	embryos
T8163	2588-2592	PR_EXT:000004503	denotes	Atrx
T8164	2626-2633	UBERON:0000479	denotes	tissues
T8165	2641-2647	UBERON:0000922	denotes	embryo
T8166	2677-2681	PR_EXT:000004503	denotes	Atrx
T8167	2692-2701	GO:0010467	denotes	expressed
T8168	2735-2741	UBERON:0000922	denotes	embryo
T8169	2788-2792	PR_EXT:000004503	denotes	Atrx
T8170	2842-2857	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T8171	2858-2865	UBERON:0000479	denotes	tissues
T8172	2912-2918	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8173	2919-2926	UBERON:0000922	denotes	embryos
T8174	2931-2938	SO_EXT:sequence_rescue_process	denotes	rescued
T8175	2944-2953	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T8176	2954-2976	UBERON:0005292	denotes	extraembryonic tissues
T8177	3015-3019	PR_EXT:000004503	denotes	Atrx
T8178	3033-3038	NCBITaxon:10088	denotes	mouse
T8179	3127-3131	PR_EXT:000004503	denotes	Atrx
T8180	3132-3136	SO:0000359	denotes	flox
T8181	3137-3143	SO_EXT:0001023	denotes	allele
T8182	3182-3188	UBERON:0000479	denotes	tissue
T8183	3202-3212	SO_EXT:0000902	denotes	transgenes
T8184	3289-3293	PR_EXT:000004503	denotes	Atrx
T8185	3301-3309	CL:0000540	denotes	neuronal
T8186	3310-3325	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8187	3329-3334	UBERON:0007023	denotes	adult
T8188	3335-3339	NCBITaxon:10088	denotes	mice
T8189	3368-3372	PR_EXT:000004503	denotes	Atrx
T8190	3409-3414	NCBITaxon:10088	denotes	mouse
T8191	3480-3484	PR_EXT:000004503	denotes	Atrx
T8192	3494-3499	CL_GO_EXT:cell	denotes	cells
T8193	3516-3523	UBERON:0000479	denotes	tissues
T8194	3535-3541	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T8195	3542-3546	NCBITaxon:10088	denotes	mice
T8196	3554-3561	UBERON:0000479	denotes	tissues
T8197	3593-3597	PR_EXT:000004503	denotes	Atrx
T8198	3611-3615	PR_EXT:000004503	denotes	Atrx
T8199	3625-3630	CL_GO_EXT:cell	denotes	cells
T8200	3653-3654	GO:0000805	denotes	X
T8201	3653-3667	GO:0009048	denotes	X-inactivation
T8202	3704-3708	PR_EXT:000004503	denotes	Atrx
T8203	3736-3741	NCBITaxon:10088	denotes	mouse
T8204	3742-3747	SO_EXT:0000704	denotes	genes
T8205	3794-3806	GO:0007566	denotes	implantation
T8206	3807-3816	GO_EXT:fatality_or_lethality	denotes	lethality
T8207	3832-3843	UBERON:0000088	denotes	trophoblast
T8208	3847-3856	UBERON:0001987	denotes	placental
T8209	3968-3972	PR_EXT:000004503	denotes	Atrx
T8210	3976-3987	UBERON:0000088	denotes	trophoblast
T8211	4001-4005	PR_EXT:000004503	denotes	Atrx
T8212	4006-4012	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8213	4013-4020	UBERON:0000922	denotes	embryos
T8214	4043-4050	UBERON:0000922	denotes	embryos
T8215	4099-4115	_FRAGMENT	denotes	specification of
T8216	4128-4138	GO:0048866	denotes	stem cells
T8217	4116-4127	UBERON:0000088	denotes	trophoblast
T8218	4116-4127	_FRAGMENT	denotes	trophoblast
T8219	4133-4138	CL:0000351	denotes	cells
T8220	4128-4138	CL:0000034	denotes	stem cells
T8221	4133-4138	CL_GO_EXT:cell	denotes	cells
T8222	4148-4152	PR_EXT:000005296	denotes	Cdx2
T8223	4160-4169	CL:0000034	denotes	stem cell
T8224	4160-4181	GO:0019827	denotes	stem cell maintenance
T8225	4160-4169	_FRAGMENT	denotes	stem cell
T8226	4186-4199	GO:0072089	denotes	proliferation
T8227	4165-4169	CL_GO_EXT:cell	denotes	cell
T8228	4209-4214	PR_EXT:000003463	denotes	Eomes
T8229	4217-4221	PR_EXT:000005296	denotes	Cdx2
T8230	4222-4228	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8231	4229-4236	UBERON:0000922	denotes	embryos
T8232	4245-4252	GO:0007566	denotes	implant
T8233	4257-4260	GO:0016265	denotes	die
T8234	4297-4302	PR_EXT:000003463	denotes	Eomes
T8235	4303-4309	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8236	4310-4321	UBERON:0000358	denotes	blastocysts
T8237	4322-4329	GO:0007566	denotes	implant
T8238	4339-4345	UBERON:0000995	denotes	uterus
T8239	4369-4381	GO:0007566	denotes	implantation
T8240	4408-4417	_FRAGMENT	denotes	embryonic
T8241	4436-4446	UBERON:0002050	denotes	structures
T8242	4421-4446	UBERON:0000478	denotes	extraembryonic structures
T8243	4466-4470	PR_EXT:000004503	denotes	Atrx
T8244	4471-4477	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8245	4478-4485	UBERON:0000922	denotes	embryos
T8246	4486-4493	GO:0007566	denotes	implant
T8247	4531-4551	UBERON:0002050	denotes	embryonic structures
T8248	4568-4572	PR_EXT:000004503	denotes	Atrx
T8249	4573-4579	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8250	4625-4629	NCBITaxon:10088	denotes	mice
T8251	4650-4655	CHEBI_EXT:22695	denotes	basic
T8252	4656-4661	SO_EXT:0001114	denotes	helix
T8253	4667-4672	SO_EXT:0001114	denotes	helix
T8254	4673-4686	GO_EXT:transcription	denotes	transcription
T8255	4673-4693	GO_EXT:transcription_factor	denotes	transcription factor
T8256	4694-4699	PR_EXT:000008439	denotes	Hand1
T8257	4701-4706	PR_EXT:000008439	denotes	Hand1
T8258	4707-4713	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8259	4772-4781	UBERON:0000922	denotes	embryonic
T8260	4805-4809	PR_EXT:000004503	denotes	Atrx
T8261	4810-4816	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8262	4817-4824	UBERON:0000922	denotes	embryos
T8263	4838-4843	PR_EXT:000008439	denotes	Hand1
T8264	4882-4900	UBERON:0004364	denotes	ectoplacental cone
T8265	4916-4920	CL:0002488	denotes	TGCs
T8266	4935-4939	PR_EXT:000004503	denotes	Atrx
T8267	4940-4947	SO_EXT:sequence_altered_entity	denotes	mutants
T8268	4975-4980	PR_EXT:000008439	denotes	Hand1
T8269	4981-4987	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8270	4988-4999	UBERON:0004716	denotes	conceptuses
T8271	5040-5044	PR_EXT:000004503	denotes	Atrx
T8272	5060-5065	PR_EXT:000008439	denotes	Hand1
T8273	5087-5107	CL:0002498	denotes	secondary giant cell
T8274	5103-5107	CL_GO_EXT:cell	denotes	cell
T8275	5103-5117	GO:0048468	denotes	cell formation
T8276	5131-5142	UBERON:0000088	denotes	trophoblast
T8277	5159-5170	UBERON:0000358	denotes	blastocysts
T8278	5188-5193	PR_EXT:000008439	denotes	Hand1
T8279	5219-5234	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8280	5238-5252	CL:0002498	denotes	secondary TGCs
T8281	5273-5284	UBERON:0000088	denotes	trophoblast
T8282	5273-5290	CL:0000351	denotes	trophoblast cells
T8283	5285-5290	CL_GO_EXT:cell	denotes	cells
T8284	5326-5344	UBERON:0004364	denotes	ectoplacental cone
T8285	5382-5386	PR_EXT:000004503	denotes	Atrx
T8286	5392-5397	PR_EXT:000008439	denotes	Hand1
T8287	5398-5404	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8288	5440-5444	PR_EXT:000004503	denotes	Atrx
T8289	5455-5470	GO_EXT:transcription	denotes	transcriptional
T8290	5471-5480	GO_EXT:regulator	denotes	regulator
T8291	5494-5503	GO:0000785	denotes	chromatin
T8292	5559-5563	PR_EXT:000004503	denotes	Atrx
T8293	5576-5585	GO_EXT:regulator	denotes	regulator
T8294	5589-5594	PR_EXT:000008439	denotes	Hand1
T8295	5595-5605	GO:0010467	denotes	expression
T8296	5648-5657	GO_EXT:regulator	denotes	regulator
T8297	5691-5706	GO_EXT:transcription	denotes	transcriptional
T8298	5718-5723	PR_EXT:000008439	denotes	Hand1
T8299	5755-5760	UBERON:0000955	denotes	brain
T8300	5770-5774	PR_EXT:000004503	denotes	Atrx
T8301	5784-5788	NCBITaxon:10088	denotes	mice
T8302	5828-5843	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T8303	5844-5851	CL:0000540	denotes	neurons
T8304	5862-5876	CL:0002498	denotes	secondary TGCs
T8305	5903-5907	PR_EXT:000004503	denotes	Atrx
T8306	5969-5983	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T8307	5984-5991	UBERON:0000479	denotes	tissues
T8308	6010-6015	NCBITaxon:10088	denotes	mouse
T8309	6059-6063	PR_EXT:000004503	denotes	Atrx
T8310	6082-6092	GO:0010467	denotes	expression
T8311	6101-6107	UBERON:0000479	denotes	tissue
T8312	6117-6122	SO_EXT:0000704	denotes	genes
T8313	6150-6165	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8314	6188-6194	CHEBI:5386	denotes	globin
T8315	6195-6200	SO_EXT:0000704	denotes	genes
T8316	6221-6236	GO_EXT:transcription	denotes	transcriptional
T8317	6248-6258	GO:0065007	denotes	regulation
T8318	6262-6267	NCBITaxon:9606	denotes	human
T8319	6268-6272	PR_EXT:000004503	denotes	ATRX
T8320	6290-6299	GO:0010467	denotes	expressed
T8321	6329-6344	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8322	6356-6365	CL:0000764	denotes	erythroid
R4819	T8087	T8086	_lexicallyChainedTo	cell,diploid
R4820	T8216	T8215	_lexicallyChainedTo	stem cells,specification of
R4821	T8219	T8218	_lexicallyChainedTo	cells,trophoblast
R4822	T8226	T8225	_lexicallyChainedTo	proliferation,stem cell
R4823	T8241	T8240	_lexicallyChainedTo	structures,embryonic

2_test

Id	Subject	Object	Predicate	Lexical cue
16628246-6895086-85799762	600-602	6895086	denotes	22
16628246-10873707-85799763	787-789	10873707	denotes	23
16628246-7985020-85799764	1032-1034	7985020	denotes	24
16628246-15668733-85799765	3341-3343	15668733	denotes	20
16628246-11433360-85799766	3885-3887	11433360	denotes	25
16628246-9052785-85799767	4286-4288	9052785	denotes	26
16628246-10716450-85799768	4448-4450	10716450	denotes	27
16628246-9500551-85799769	4922-4924	9500551	denotes	28
16628246-10611232-85799770	5346-5348	10611232	denotes	17
16628246-9500551-85799771	5349-5351	9500551	denotes	28
16628246-15668733-85799772	5853-5855	15668733	denotes	20
T47412	600-602	6895086	denotes	22
T89259	787-789	10873707	denotes	23
T98024	1032-1034	7985020	denotes	24
T95738	3341-3343	15668733	denotes	20
T36669	3885-3887	11433360	denotes	25
T78131	4286-4288	9052785	denotes	26
T46656	4448-4450	10716450	denotes	27
T27799	4922-4924	9500551	denotes	28
T13124	5346-5348	10611232	denotes	17
T42247	5349-5351	9500551	denotes	28
T83367	5853-5855	15668733	denotes	20

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7865	23-27	PR:000004503	denotes	Atrx
T7866	50-55	NCBITaxon:10088	denotes	Mouse
T7867	56-67	UBERON:0000088	denotes	Trophoblast
T7868	81-85	PR:000004503	denotes	Atrx
T7869	95-99	NCBITaxon:10088	denotes	mice
T7870	119-126	UBERON:0000922	denotes	embryos
T7871	127-130	GO:0016265	denotes	die
T7872	157-162	GO:0016265	denotes	death
T7873	164-168	PR:000004503	denotes	Atrx
T7874	173-180	UBERON:0000922	denotes	embryos
T7875	208-215	GO:0007067	denotes	mitotic
T7876	271-280	UBERON:0000922	denotes	embryonic
T7877	300-309	UBERON:0004716	denotes	conceptus
T7878	347-351	PR:000004503	denotes	Atrx
T7879	356-363	UBERON:0000922	denotes	embryos
T7880	408-419	UBERON:0000088	denotes	trophoblast
T7881	464-468	CL:0002488	denotes	TGCs
T7882	485-494	UBERON:0004716	denotes	conceptus
T7883	530-548	UBERON:0004364	denotes	ectoplacental cone
T7884	569-576	_FRAGMENT	denotes	diploid
T7885	583-587	CL:0000415	denotes	cell
T7886	577-587	CL:0002488	denotes	giant cell
T7887	605-609	CL:0002488	denotes	TGCs
T7888	641-648	GO:0007067	denotes	mitotic
T7889	679-689	UBERON:0000483	denotes	epithelial
T7890	720-728	UBERON:0001987	denotes	placenta
T7891	778-785	UBERON:0002450	denotes	decidua
T7892	872-879	UBERON:0000995	denotes	uterine
T7893	880-886	UBERON:0000479	denotes	tissue
T7894	938-945	UBERON:0002450	denotes	decidua
T7895	952-964	GO:0007566	denotes	implantation
T7896	972-981	GO:0046903	denotes	secreting
T7897	996-1004	GO:0065007	denotes	regulate
T7898	1043-1047	PR:000004503	denotes	Atrx
T7899	1052-1059	UBERON:0000922	denotes	embryos
T7900	1070-1077	GO:0007566	denotes	implant
T7901	1137-1140	CL:0002488	denotes	TGC
T7902	1176-1185	UBERON:0000922	denotes	Embryonic
T7903	1199-1203	NCBITaxon:10088	denotes	mice
T7904	1222-1226	PR:000004503	denotes	Atrx
T7905	1307-1312	NCBITaxon:9606	denotes	human
T7906	1317-1318	GO:0000805	denotes	X
T7907	1361-1365	PR:000004503	denotes	Atrx
T7908	1373-1384	UBERON:0000088	denotes	trophoblast
T7909	1400-1404	NCBITaxon:10088	denotes	mice
T7910	1414-1418	PR:000004503	denotes	ATRX
T7911	1454-1459	NCBITaxon:9606	denotes	human
T7912	1460-1471	UBERON:0000088	denotes	trophoblast
T7913	1485-1490	GO:0007567	denotes	birth
T7914	1517-1518	GO:0000805	denotes	X
T7915	1627-1631	NCBITaxon:10088	denotes	mice
T7916	1644-1648	PR:000004503	denotes	Atrx
T7917	1728-1732	PR:000004503	denotes	Atrx
T7918	1814-1819	NCBITaxon:9606	denotes	human
T7919	1824-1825	GO:0000805	denotes	X
T7920	1871-1878	SO:0001023	denotes	alleles
T7921	1897-1901	PR:000004503	denotes	ATRX
T7922	2027-2031	PR:000004503	denotes	ATRX
T7923	2070-2088	NCBITaxon:10376	denotes	Epstein-Barr virus
T7924	2089-2100	GO:0009294	denotes	transformed
T7925	2101-2112	CL:0000542	denotes	lymphocytes
T7926	2120-2125	NCBITaxon:9606	denotes	human
T7927	2236-2240	PR:000004503	denotes	ATRX
T7928	2241-2247	SO:0001023	denotes	allele
T7929	2254-2259	NCBITaxon:9606	denotes	human
T7930	2303-2308	NCBITaxon:10088	denotes	mouse
T7931	2334-2338	PR:000004503	denotes	ATRX
T7932	2368-2373	NCBITaxon:9606	denotes	human
T7933	2443-2447	PR:000004503	denotes	Atrx
T7934	2455-2461	NCBITaxon:39107	denotes	murine
T7935	2462-2475	UBERON:0004345	denotes	trophectoderm
T7936	2524-2528	PR:000004503	denotes	Atrx
T7937	2533-2540	UBERON:0000922	denotes	embryos
T7938	2588-2592	PR:000004503	denotes	Atrx
T7939	2626-2633	UBERON:0000479	denotes	tissues
T7940	2641-2647	UBERON:0000922	denotes	embryo
T7941	2677-2681	PR:000004503	denotes	Atrx
T7942	2692-2701	GO:0010467	denotes	expressed
T7943	2735-2741	UBERON:0000922	denotes	embryo
T7944	2788-2792	PR:000004503	denotes	Atrx
T7945	2858-2865	UBERON:0000479	denotes	tissues
T7946	2919-2926	UBERON:0000922	denotes	embryos
T7947	2954-2976	UBERON:0005292	denotes	extraembryonic tissues
T7948	3015-3019	PR:000004503	denotes	Atrx
T7949	3033-3038	NCBITaxon:10088	denotes	mouse
T7950	3127-3131	PR:000004503	denotes	Atrx
T7951	3132-3136	SO:0000359	denotes	flox
T7952	3137-3143	SO:0001023	denotes	allele
T7953	3182-3188	UBERON:0000479	denotes	tissue
T7954	3202-3212	SO:0000902	denotes	transgenes
T7955	3289-3293	PR:000004503	denotes	Atrx
T7956	3301-3309	CL:0000540	denotes	neuronal
T7957	3329-3334	UBERON:0007023	denotes	adult
T7958	3335-3339	NCBITaxon:10088	denotes	mice
T7959	3368-3372	PR:000004503	denotes	Atrx
T7960	3409-3414	NCBITaxon:10088	denotes	mouse
T7961	3480-3484	PR:000004503	denotes	Atrx
T7962	3516-3523	UBERON:0000479	denotes	tissues
T7963	3542-3546	NCBITaxon:10088	denotes	mice
T7964	3554-3561	UBERON:0000479	denotes	tissues
T7965	3593-3597	PR:000004503	denotes	Atrx
T7966	3611-3615	PR:000004503	denotes	Atrx
T7967	3653-3654	GO:0000805	denotes	X
T7968	3653-3667	GO:0009048	denotes	X-inactivation
T7969	3704-3708	PR:000004503	denotes	Atrx
T7970	3736-3741	NCBITaxon:10088	denotes	mouse
T7971	3742-3747	SO:0000704	denotes	genes
T7972	3794-3806	GO:0007566	denotes	implantation
T7973	3832-3843	UBERON:0000088	denotes	trophoblast
T7974	3847-3856	UBERON:0001987	denotes	placental
T7975	3968-3972	PR:000004503	denotes	Atrx
T7976	3976-3987	UBERON:0000088	denotes	trophoblast
T7977	4001-4005	PR:000004503	denotes	Atrx
T7978	4013-4020	UBERON:0000922	denotes	embryos
T7979	4043-4050	UBERON:0000922	denotes	embryos
T7980	4099-4115	_FRAGMENT	denotes	specification of
T7981	4128-4138	GO:0048866	denotes	stem cells
T7982	4116-4127	UBERON:0000088	denotes	trophoblast
T7983	4116-4127	_FRAGMENT	denotes	trophoblast
T7984	4133-4138	CL:0000351	denotes	cells
T7985	4128-4138	CL:0000034	denotes	stem cells
T7986	4148-4152	PR:000005296	denotes	Cdx2
T7987	4160-4169	CL:0000034	denotes	stem cell
T7988	4160-4181	GO:0019827	denotes	stem cell maintenance
T7989	4160-4169	_FRAGMENT	denotes	stem cell
T7990	4186-4199	GO:0072089	denotes	proliferation
T7991	4209-4214	PR:000003463	denotes	Eomes
T7992	4217-4221	PR:000005296	denotes	Cdx2
T7993	4229-4236	UBERON:0000922	denotes	embryos
T7994	4245-4252	GO:0007566	denotes	implant
T7995	4257-4260	GO:0016265	denotes	die
T7996	4297-4302	PR:000003463	denotes	Eomes
T7997	4310-4321	UBERON:0000358	denotes	blastocysts
T7998	4322-4329	GO:0007566	denotes	implant
T7999	4339-4345	UBERON:0000995	denotes	uterus
T8000	4369-4381	GO:0007566	denotes	implantation
T8001	4408-4417	_FRAGMENT	denotes	embryonic
T8002	4436-4446	UBERON:0002050	denotes	structures
T8003	4421-4446	UBERON:0000478	denotes	extraembryonic structures
T8004	4466-4470	PR:000004503	denotes	Atrx
T8005	4478-4485	UBERON:0000922	denotes	embryos
T8006	4486-4493	GO:0007566	denotes	implant
T8007	4531-4551	UBERON:0002050	denotes	embryonic structures
T8008	4568-4572	PR:000004503	denotes	Atrx
T8009	4625-4629	NCBITaxon:10088	denotes	mice
T8010	4650-4655	CHEBI:22695	denotes	basic
T8011	4656-4661	SO:0001114	denotes	helix
T8012	4667-4672	SO:0001114	denotes	helix
T8013	4694-4699	PR:000008439	denotes	Hand1
T8014	4701-4706	PR:000008439	denotes	Hand1
T8015	4772-4781	UBERON:0000922	denotes	embryonic
T8016	4805-4809	PR:000004503	denotes	Atrx
T8017	4817-4824	UBERON:0000922	denotes	embryos
T8018	4838-4843	PR:000008439	denotes	Hand1
T8019	4882-4900	UBERON:0004364	denotes	ectoplacental cone
T8020	4916-4920	CL:0002488	denotes	TGCs
T8021	4935-4939	PR:000004503	denotes	Atrx
T8022	4975-4980	PR:000008439	denotes	Hand1
T8023	4988-4999	UBERON:0004716	denotes	conceptuses
T8024	5040-5044	PR:000004503	denotes	Atrx
T8025	5060-5065	PR:000008439	denotes	Hand1
T8026	5087-5107	CL:0002498	denotes	secondary giant cell
T8027	5103-5117	GO:0048468	denotes	cell formation
T8028	5131-5142	UBERON:0000088	denotes	trophoblast
T8029	5159-5170	UBERON:0000358	denotes	blastocysts
T8030	5188-5193	PR:000008439	denotes	Hand1
T8031	5238-5252	CL:0002498	denotes	secondary TGCs
T8032	5273-5284	UBERON:0000088	denotes	trophoblast
T8033	5273-5290	CL:0000351	denotes	trophoblast cells
T8034	5326-5344	UBERON:0004364	denotes	ectoplacental cone
T8035	5382-5386	PR:000004503	denotes	Atrx
T8036	5392-5397	PR:000008439	denotes	Hand1
T8037	5440-5444	PR:000004503	denotes	Atrx
T8038	5494-5503	GO:0000785	denotes	chromatin
T8039	5559-5563	PR:000004503	denotes	Atrx
T8040	5589-5594	PR:000008439	denotes	Hand1
T8041	5595-5605	GO:0010467	denotes	expression
T8042	5718-5723	PR:000008439	denotes	Hand1
T8043	5755-5760	UBERON:0000955	denotes	brain
T8044	5770-5774	PR:000004503	denotes	Atrx
T8045	5784-5788	NCBITaxon:10088	denotes	mice
T8046	5844-5851	CL:0000540	denotes	neurons
T8047	5862-5876	CL:0002498	denotes	secondary TGCs
T8048	5903-5907	PR:000004503	denotes	Atrx
T8049	5984-5991	UBERON:0000479	denotes	tissues
T8050	6010-6015	NCBITaxon:10088	denotes	mouse
T8051	6059-6063	PR:000004503	denotes	Atrx
T8052	6082-6092	GO:0010467	denotes	expression
T8053	6101-6107	UBERON:0000479	denotes	tissue
T8054	6117-6122	SO:0000704	denotes	genes
T8055	6188-6194	CHEBI:5386	denotes	globin
T8056	6195-6200	SO:0000704	denotes	genes
T8057	6248-6258	GO:0065007	denotes	regulation
T8058	6262-6267	NCBITaxon:9606	denotes	human
T8059	6268-6272	PR:000004503	denotes	ATRX
T8060	6290-6299	GO:0010467	denotes	expressed
T8061	6356-6365	CL:0000764	denotes	erythroid
R4817	T7990	T7989	_lexicallyChainedTo	proliferation,stem cell
R4818	T8002	T8001	_lexicallyChainedTo	structures,embryonic
R4814	T7885	T7884	_lexicallyChainedTo	cell,diploid
R4815	T7981	T7980	_lexicallyChainedTo	stem cells,specification of
R4816	T7984	T7983	_lexicallyChainedTo	cells,trophoblast

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