PMC:1440874 / 35970-50060 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T7224	169-171	NN	denotes	ES
T7225	172-177	NNS	denotes	cells
T7226	178-181	CC	denotes	and
T7227	182-190	JJ	denotes	embryoid
T7228	191-197	NNS	denotes	bodies
T7229	197-199	,	denotes	,
T7230	199-202	CC	denotes	and
T7231	203-207	RB	denotes	then
T7232	208-210	IN	denotes	in
T7233	211-221	VBG	denotes	developing
T7234	228-235	NNS	denotes	embryos
T7235	222-227	NN	denotes	mouse
T7236	235-236	.	denotes	.
T7415	238-242	NN	denotes	Atrx
T7416	243-245	IN	denotes	in
T7417	246-248	NN	denotes	ES
T7418	249-254	NNS	denotes	Cells
T7419	254-391	sentence	denotes	Atrxnull ES cells could not be recovered by direct targeting and were eventually generated by adopting a conditional targeting approach.
T7420	255-263	JJ	denotes	Atrxnull
T7421	264-266	NN	denotes	ES
T7422	267-272	NNS	denotes	cells
T7423	286-295	VBN	denotes	recovered
T7424	273-278	MD	denotes	could
T7425	279-282	RB	denotes	not
T7426	283-285	VB	denotes	be
T7427	296-298	IN	denotes	by
T7428	299-305	JJ	denotes	direct
T7429	306-315	NN	denotes	targeting
T7430	316-319	CC	denotes	and
T7431	320-324	VBD	denotes	were
T7432	336-345	VBN	denotes	generated
T7433	325-335	RB	denotes	eventually
T7434	346-348	IN	denotes	by
T7435	349-357	VBG	denotes	adopting
T7436	358-359	DT	denotes	a
T7437	382-390	NN	denotes	approach
T7438	360-371	JJ	denotes	conditional
T7439	372-381	NN	denotes	targeting
T7440	390-391	.	denotes	.
T7441	391-597	sentence	denotes	This is consistent with our observation that Atrx is highly expressed in ES cells, and that the absence of full-length Atrx imparts a growth disadvantage relative to cells bearing a functional Atrx allele.
T7442	392-396	DT	denotes	This
T7443	397-399	VBZ	denotes	is
T7444	400-410	JJ	denotes	consistent
T7445	411-415	IN	denotes	with
T7446	416-419	PRP$	denotes	our
T7447	420-431	NN	denotes	observation
T7448	432-436	IN	denotes	that
T7449	442-444	VBZ	denotes	is
T7450	437-441	NN	denotes	Atrx
T7451	445-451	RB	denotes	highly
T7452	452-461	JJ	denotes	expressed
T7453	462-464	IN	denotes	in
T7454	465-467	NN	denotes	ES
T7455	468-473	NNS	denotes	cells
T7456	473-475	,	denotes	,
T7457	475-478	CC	denotes	and
T7458	479-483	IN	denotes	that
T7459	516-523	VBZ	denotes	imparts
T7460	484-487	DT	denotes	the
T7461	488-495	NN	denotes	absence
T7462	496-498	IN	denotes	of
T7463	499-503	JJ	denotes	full
T7464	504-510	NN	denotes	length
T7465	503-504	HYPH	denotes	-
T7466	511-515	NN	denotes	Atrx
T7467	524-525	DT	denotes	a
T7468	533-545	NN	denotes	disadvantage
T7469	526-532	NN	denotes	growth
T7470	546-554	JJ	denotes	relative
T7471	555-557	IN	denotes	to
T7472	558-563	NNS	denotes	cells
T7473	564-571	VBG	denotes	bearing
T7474	572-573	DT	denotes	a
T7475	590-596	NN	denotes	allele
T7476	574-584	JJ	denotes	functional
T7477	585-589	NN	denotes	Atrx
T7478	596-597	.	denotes	.
T7479	597-681	sentence	denotes	At present, the cause of the proliferative delay in Atrxnull ES cells is not known.
T7480	598-600	IN	denotes	At
T7481	668-670	VBZ	denotes	is
T7482	601-608	JJ	denotes	present
T7483	608-610	,	denotes	,
T7484	610-613	DT	denotes	the
T7485	614-619	NN	denotes	cause
T7486	620-622	IN	denotes	of
T7487	623-626	DT	denotes	the
T7488	641-646	NN	denotes	delay
T7489	627-640	JJ	denotes	proliferative
T7490	647-649	IN	denotes	in
T7491	650-658	JJ	denotes	Atrxnull
T7492	662-667	NNS	denotes	cells
T7493	659-661	NN	denotes	ES
T7494	671-674	RB	denotes	not
T7495	675-680	JJ	denotes	known
T7496	680-681	.	denotes	.
T7497	681-849	sentence	denotes	Interestingly, we demonstrated that apoptosis is not significantly up-regulated in ES cells lacking Atrx and is only mildly elevated in Atrxnull 7.5 dpc mouse embryos.
T7498	682-695	RB	denotes	Interestingly
T7499	700-712	VBD	denotes	demonstrated
T7500	695-697	,	denotes	,
T7501	697-699	PRP	denotes	we
T7502	713-717	IN	denotes	that
T7503	752-761	VBN	denotes	regulated
T7504	718-727	NN	denotes	apoptosis
T7505	728-730	VBZ	denotes	is
T7506	731-734	RB	denotes	not
T7507	735-748	RB	denotes	significantly
T7508	749-751	RB	denotes	up
T7509	751-752	HYPH	denotes	-
T7510	762-764	IN	denotes	in
T7511	765-767	NN	denotes	ES
T7512	768-773	NNS	denotes	cells
T7513	774-781	VBG	denotes	lacking
T7514	782-786	NN	denotes	Atrx
T7515	787-790	CC	denotes	and
T7516	791-793	VBZ	denotes	is
T7517	794-798	RB	denotes	only
T7518	799-805	RB	denotes	mildly
T7519	806-814	JJ	denotes	elevated
T7520	815-817	IN	denotes	in
T7521	818-826	JJ	denotes	Atrxnull
T7522	841-848	NNS	denotes	embryos
T7523	827-830	CD	denotes	7.5
T7524	831-834	NN	denotes	dpc
T7525	835-840	NN	denotes	mouse
T7526	848-849	.	denotes	.
T7527	849-1145	sentence	denotes	In contrast, it was recently shown that the loss of Atrx markedly increased the apoptotic population in the differentiating cells of the embryonic cortex and postnatal hippocampus, when Atrx expression was ablated in the developing mouse forebrain using the Atrx flox allele described here [20].
T7528	850-852	IN	denotes	In
T7529	879-884	VBN	denotes	shown
T7530	853-861	NN	denotes	contrast
T7531	861-863	,	denotes	,
T7532	863-865	PRP	denotes	it
T7533	866-869	VBD	denotes	was
T7534	870-878	RB	denotes	recently
T7535	885-889	IN	denotes	that
T7536	916-925	VBD	denotes	increased
T7537	890-893	DT	denotes	the
T7538	894-898	NN	denotes	loss
T7539	899-901	IN	denotes	of
T7540	902-906	NN	denotes	Atrx
T7541	907-915	RB	denotes	markedly
T7542	926-929	DT	denotes	the
T7543	940-950	NN	denotes	population
T7544	930-939	JJ	denotes	apoptotic
T7545	951-953	IN	denotes	in
T7546	954-957	DT	denotes	the
T7547	974-979	NNS	denotes	cells
T7548	958-973	VBG	denotes	differentiating
T7549	980-982	IN	denotes	of
T7550	983-986	DT	denotes	the
T7551	997-1003	NN	denotes	cortex
T7552	987-996	JJ	denotes	embryonic
T7553	1004-1007	CC	denotes	and
T7554	1008-1017	JJ	denotes	postnatal
T7555	1018-1029	NN	denotes	hippocampus
T7556	1029-1031	,	denotes	,
T7557	1031-1035	WRB	denotes	when
T7558	1056-1063	VBN	denotes	ablated
T7559	1036-1040	NN	denotes	Atrx
T7560	1041-1051	NN	denotes	expression
T7561	1052-1055	VBD	denotes	was
T7562	1064-1066	IN	denotes	in
T7563	1067-1070	DT	denotes	the
T7564	1088-1097	NN	denotes	forebrain
T7565	1071-1081	VBG	denotes	developing
T7566	1082-1087	NN	denotes	mouse
T7567	1098-1103	VBG	denotes	using
T7568	1104-1107	DT	denotes	the
T7569	1118-1124	NN	denotes	allele
T7570	1108-1117	NN	denotes	Atrx flox
T7571	1125-1134	VBN	denotes	described
T7572	1135-1139	RB	denotes	here
T7573	1140-1141	-LRB-	denotes	[
T7574	1141-1143	CD	denotes	20
T7575	1143-1144	-RRB-	denotes	]
T7576	1144-1145	.	denotes	.
T7577	1145-1318	sentence	denotes	The human ATRX protein has been shown to associate in a complex with Daxx [8], a protein that has been implicated in multiple pathways for the regulation of apoptosis [21].
T7578	1146-1149	DT	denotes	The
T7579	1161-1168	NN	denotes	protein
T7580	1150-1155	JJ	denotes	human
T7581	1156-1160	NN	denotes	ATRX
T7582	1178-1183	VBN	denotes	shown
T7583	1169-1172	VBZ	denotes	has
T7584	1173-1177	VBN	denotes	been
T7585	1184-1186	TO	denotes	to
T7586	1187-1196	VB	denotes	associate
T7587	1197-1199	IN	denotes	in
T7588	1200-1201	DT	denotes	a
T7589	1202-1209	NN	denotes	complex
T7590	1210-1214	IN	denotes	with
T7591	1215-1219	NN	denotes	Daxx
T7592	1220-1221	-LRB-	denotes	[
T7593	1221-1222	CD	denotes	8
T7594	1222-1223	-RRB-	denotes	]
T7595	1223-1225	,	denotes	,
T7596	1225-1226	DT	denotes	a
T7597	1227-1234	NN	denotes	protein
T7598	1235-1239	WDT	denotes	that
T7599	1249-1259	VBN	denotes	implicated
T7600	1240-1243	VBZ	denotes	has
T7601	1244-1248	VBN	denotes	been
T7602	1260-1262	IN	denotes	in
T7603	1263-1271	JJ	denotes	multiple
T7604	1272-1280	NNS	denotes	pathways
T7605	1281-1284	IN	denotes	for
T7606	1285-1288	DT	denotes	the
T7607	1289-1299	NN	denotes	regulation
T7608	1300-1302	IN	denotes	of
T7609	1303-1312	NN	denotes	apoptosis
T7610	1313-1314	-LRB-	denotes	[
T7611	1314-1316	CD	denotes	21
T7612	1316-1317	-RRB-	denotes	]
T7613	1317-1318	.	denotes	.
T7614	1318-1470	sentence	denotes	It is possible that disruption of the mouse Atrx-Daxx complex (by ablation of the Atrx protein) could have triggered a universal proapoptotic response.
T7615	1319-1321	PRP	denotes	It
T7616	1322-1324	VBZ	denotes	is
T7617	1325-1333	JJ	denotes	possible
T7618	1334-1338	IN	denotes	that
T7619	1426-1435	VBN	denotes	triggered
T7620	1339-1349	NN	denotes	disruption
T7621	1350-1352	IN	denotes	of
T7622	1353-1356	DT	denotes	the
T7623	1373-1380	NN	denotes	complex
T7624	1357-1362	NN	denotes	mouse
T7625	1363-1367	NN	denotes	Atrx
T7626	1368-1372	NN	denotes	Daxx
T7627	1367-1368	HYPH	denotes	-
T7628	1381-1382	-LRB-	denotes	(
T7629	1382-1384	IN	denotes	by
T7630	1385-1393	NN	denotes	ablation
T7631	1394-1396	IN	denotes	of
T7632	1397-1400	DT	denotes	the
T7633	1406-1413	NN	denotes	protein
T7634	1401-1405	NN	denotes	Atrx
T7635	1413-1414	-RRB-	denotes	)
T7636	1415-1420	MD	denotes	could
T7637	1421-1425	VB	denotes	have
T7638	1436-1437	DT	denotes	a
T7639	1461-1469	NN	denotes	response
T7640	1438-1447	JJ	denotes	universal
T7641	1448-1460	JJ	denotes	proapoptotic
T7642	1469-1470	.	denotes	.
T7643	1470-1784	sentence	denotes	However, our observations in ES cells demonstrate that the induction of apoptosis is not an automatic response triggered by the removal of Atrx in all cell types, and suggest that the inappropriate apoptosis observed in the Atrx-mutant forebrain may reflect a requirement for Atrx during terminal differentiation.
T7644	1471-1478	RB	denotes	However
T7645	1509-1520	VBP	denotes	demonstrate
T7646	1478-1480	,	denotes	,
T7647	1480-1483	PRP$	denotes	our
T7648	1484-1496	NNS	denotes	observations
T7649	1497-1499	IN	denotes	in
T7650	1500-1502	NN	denotes	ES
T7651	1503-1508	NNS	denotes	cells
T7652	1521-1525	IN	denotes	that
T7653	1553-1555	VBZ	denotes	is
T7654	1526-1529	DT	denotes	the
T7655	1530-1539	NN	denotes	induction
T7656	1540-1542	IN	denotes	of
T7657	1543-1552	NN	denotes	apoptosis
T7658	1556-1559	RB	denotes	not
T7659	1560-1562	DT	denotes	an
T7660	1573-1581	NN	denotes	response
T7661	1563-1572	JJ	denotes	automatic
T7662	1582-1591	VBN	denotes	triggered
T7663	1592-1594	IN	denotes	by
T7664	1595-1598	DT	denotes	the
T7665	1599-1606	NN	denotes	removal
T7666	1607-1609	IN	denotes	of
T7667	1610-1614	NN	denotes	Atrx
T7668	1615-1617	IN	denotes	in
T7669	1618-1621	DT	denotes	all
T7670	1627-1632	NNS	denotes	types
T7671	1622-1626	NN	denotes	cell
T7672	1632-1634	,	denotes	,
T7673	1634-1637	CC	denotes	and
T7674	1638-1645	VBP	denotes	suggest
T7675	1646-1650	IN	denotes	that
T7676	1721-1728	VB	denotes	reflect
T7677	1651-1654	DT	denotes	the
T7678	1669-1678	NN	denotes	apoptosis
T7679	1655-1668	JJ	denotes	inappropriate
T7680	1679-1687	VBN	denotes	observed
T7681	1688-1690	IN	denotes	in
T7682	1691-1694	DT	denotes	the
T7683	1707-1716	NN	denotes	forebrain
T7684	1695-1699	NN	denotes	Atrx
T7685	1700-1706	NN	denotes	mutant
T7686	1699-1700	HYPH	denotes	-
T7687	1717-1720	MD	denotes	may
T7688	1729-1730	DT	denotes	a
T7689	1731-1742	NN	denotes	requirement
T7690	1743-1746	IN	denotes	for
T7691	1747-1751	NN	denotes	Atrx
T7692	1752-1758	IN	denotes	during
T7693	1759-1767	JJ	denotes	terminal
T7694	1768-1783	NN	denotes	differentiation
T7695	1783-1784	.	denotes	.
T8323	1786-1788	DT	denotes	An
T8324	1800-1804	NN	denotes	Role
T8325	1789-1799	JJ	denotes	Unexpected
T8326	1805-1808	IN	denotes	for
T8327	1809-1813	NN	denotes	Atrx
T8328	1814-1816	IN	denotes	in
T8329	1817-1828	NN	denotes	Development
T8330	1829-1831	IN	denotes	of
T8331	1832-1835	DT	denotes	the
T8332	1842-1853	NN	denotes	Trophoblast
T8333	1836-1841	NN	denotes	Mouse
T8334	1853-1935	sentence	denotes	We show that Atrxnull male mice are not viable and embryos die by around 9.5 dpc.
T8335	1854-1856	PRP	denotes	We
T8336	1857-1861	VBP	denotes	show
T8337	1862-1866	IN	denotes	that
T8338	1886-1889	VBP	denotes	are
T8339	1867-1875	JJ	denotes	Atrxnull
T8340	1881-1885	NNS	denotes	mice
T8341	1876-1880	JJ	denotes	male
T8342	1890-1893	RB	denotes	not
T8343	1894-1900	JJ	denotes	viable
T8344	1901-1904	CC	denotes	and
T8345	1905-1912	NNS	denotes	embryos
T8346	1913-1916	VBP	denotes	die
T8347	1917-1919	IN	denotes	by
T8348	1920-1926	IN	denotes	around
T8349	1927-1930	CD	denotes	9.5
T8350	1931-1934	NN	denotes	dpc
T8351	1934-1935	.	denotes	.
T8352	1935-2043	sentence	denotes	Before death, Atrxnull embryos exhibit a markedly reduced mitotic index, suggesting a proliferative defect.
T8353	1936-1942	IN	denotes	Before
T8354	1967-1974	VBP	denotes	exhibit
T8355	1943-1948	NN	denotes	death
T8356	1948-1950	,	denotes	,
T8357	1950-1958	JJ	denotes	Atrxnull
T8358	1959-1966	NNS	denotes	embryos
T8359	1975-1976	DT	denotes	a
T8360	2002-2007	NN	denotes	index
T8361	1977-1985	RB	denotes	markedly
T8362	1986-1993	VBN	denotes	reduced
T8363	1994-2001	JJ	denotes	mitotic
T8364	2007-2009	,	denotes	,
T8365	2009-2019	VBG	denotes	suggesting
T8366	2020-2021	DT	denotes	a
T8367	2036-2042	NN	denotes	defect
T8368	2022-2035	JJ	denotes	proliferative
T8369	2042-2043	.	denotes	.
T8370	2043-2390	sentence	denotes	Although the embryonic compartment of the conceptus appears initially normal, by 7.5 dpc Atrxnull embryos display abnormalities in development of the trophoblast, including a depletion in the population of TGCs surrounding the conceptus and a reduction in the size of the ectoplacental cone, which contains the diploid giant cell precursors [22].
T8371	2044-2052	IN	denotes	Although
T8372	2096-2103	VBZ	denotes	appears
T8373	2053-2056	DT	denotes	the
T8374	2067-2078	NN	denotes	compartment
T8375	2057-2066	JJ	denotes	embryonic
T8376	2079-2081	IN	denotes	of
T8377	2082-2085	DT	denotes	the
T8378	2086-2095	NN	denotes	conceptus
T8379	2150-2157	VBP	denotes	display
T8380	2104-2113	RB	denotes	initially
T8381	2114-2120	JJ	denotes	normal
T8382	2120-2122	,	denotes	,
T8383	2122-2124	IN	denotes	by
T8384	2125-2128	CD	denotes	7.5
T8385	2129-2132	NN	denotes	dpc
T8386	2133-2141	JJ	denotes	Atrxnull
T8387	2142-2149	NNS	denotes	embryos
T8388	2158-2171	NNS	denotes	abnormalities
T8389	2172-2174	IN	denotes	in
T8390	2175-2186	NN	denotes	development
T8391	2187-2189	IN	denotes	of
T8392	2190-2193	DT	denotes	the
T8393	2194-2205	NN	denotes	trophoblast
T8394	2205-2207	,	denotes	,
T8395	2207-2216	VBG	denotes	including
T8396	2217-2218	DT	denotes	a
T8397	2219-2228	NN	denotes	depletion
T8398	2229-2231	IN	denotes	in
T8399	2232-2235	DT	denotes	the
T8400	2236-2246	NN	denotes	population
T8401	2247-2249	IN	denotes	of
T8402	2250-2254	NNS	denotes	TGCs
T8403	2255-2266	VBG	denotes	surrounding
T8404	2267-2270	DT	denotes	the
T8405	2271-2280	NN	denotes	conceptus
T8406	2281-2284	CC	denotes	and
T8407	2285-2286	DT	denotes	a
T8408	2287-2296	NN	denotes	reduction
T8409	2297-2299	IN	denotes	in
T8410	2300-2303	DT	denotes	the
T8411	2304-2308	NN	denotes	size
T8412	2309-2311	IN	denotes	of
T8413	2312-2315	DT	denotes	the
T8414	2330-2334	NN	denotes	cone
T8415	2316-2329	JJ	denotes	ectoplacental
T8416	2334-2336	,	denotes	,
T8417	2336-2341	WDT	denotes	which
T8418	2342-2350	VBZ	denotes	contains
T8419	2351-2354	DT	denotes	the
T8420	2374-2384	NNS	denotes	precursors
T8421	2355-2362	NN	denotes	diploid
T8422	2363-2368	JJ	denotes	giant
T8423	2369-2373	NN	denotes	cell
T8424	2385-2386	-LRB-	denotes	[
T8425	2386-2388	CD	denotes	22
T8426	2388-2389	-RRB-	denotes	]
T8427	2389-2390	.	denotes	.
T8428	2390-2577	sentence	denotes	TGCs are highly differentiated, postmitotic cells that ultimately form an epithelial layer at the periphery of the placenta, which interfaces with the maternal cells of the decidua [23].
T8429	2391-2395	NNS	denotes	TGCs
T8430	2396-2399	VBP	denotes	are
T8431	2400-2406	RB	denotes	highly
T8432	2407-2421	VBN	denotes	differentiated
T8433	2435-2440	NNS	denotes	cells
T8434	2421-2423	,	denotes	,
T8435	2423-2434	JJ	denotes	postmitotic
T8436	2441-2445	WDT	denotes	that
T8437	2457-2461	VBP	denotes	form
T8438	2446-2456	RB	denotes	ultimately
T8439	2462-2464	DT	denotes	an
T8440	2476-2481	NN	denotes	layer
T8441	2465-2475	JJ	denotes	epithelial
T8442	2482-2484	IN	denotes	at
T8443	2485-2488	DT	denotes	the
T8444	2489-2498	NN	denotes	periphery
T8445	2499-2501	IN	denotes	of
T8446	2502-2505	DT	denotes	the
T8447	2506-2514	NN	denotes	placenta
T8448	2514-2516	,	denotes	,
T8449	2516-2521	WDT	denotes	which
T8450	2522-2532	VBZ	denotes	interfaces
T8451	2533-2537	IN	denotes	with
T8452	2538-2541	DT	denotes	the
T8453	2551-2556	NNS	denotes	cells
T8454	2542-2550	JJ	denotes	maternal
T8455	2557-2559	IN	denotes	of
T8456	2560-2563	DT	denotes	the
T8457	2564-2571	NN	denotes	decidua
T8458	2572-2573	-LRB-	denotes	[
T8459	2573-2575	CD	denotes	23
T8460	2575-2576	-RRB-	denotes	]
T8461	2576-2577	.	denotes	.
T8462	2577-2822	sentence	denotes	These highly invasive cells are important for mediating initial invasion of the uterine tissue, but are also involved in remodelling the maternal decidua after implantation and in secreting hormones that regulate fetal and maternal growth [24].
T8463	2578-2583	DT	denotes	These
T8464	2600-2605	NNS	denotes	cells
T8465	2584-2590	RB	denotes	highly
T8466	2591-2599	JJ	denotes	invasive
T8467	2606-2609	VBP	denotes	are
T8468	2610-2619	JJ	denotes	important
T8469	2620-2623	IN	denotes	for
T8470	2624-2633	VBG	denotes	mediating
T8471	2634-2641	JJ	denotes	initial
T8472	2642-2650	NN	denotes	invasion
T8473	2651-2653	IN	denotes	of
T8474	2654-2657	DT	denotes	the
T8475	2666-2672	NN	denotes	tissue
T8476	2658-2665	JJ	denotes	uterine
T8477	2672-2674	,	denotes	,
T8478	2674-2677	CC	denotes	but
T8479	2678-2681	VBP	denotes	are
T8480	2687-2695	VBN	denotes	involved
T8481	2682-2686	RB	denotes	also
T8482	2696-2698	IN	denotes	in
T8483	2699-2710	VBG	denotes	remodelling
T8484	2711-2714	DT	denotes	the
T8485	2724-2731	NN	denotes	decidua
T8486	2715-2723	JJ	denotes	maternal
T8487	2732-2737	IN	denotes	after
T8488	2738-2750	NN	denotes	implantation
T8489	2751-2754	CC	denotes	and
T8490	2755-2757	IN	denotes	in
T8491	2758-2767	VBG	denotes	secreting
T8492	2768-2776	NNS	denotes	hormones
T8493	2777-2781	WDT	denotes	that
T8494	2782-2790	VBP	denotes	regulate
T8495	2791-2796	JJ	denotes	fetal
T8496	2810-2816	NN	denotes	growth
T8497	2797-2800	CC	denotes	and
T8498	2801-2809	JJ	denotes	maternal
T8499	2817-2818	-LRB-	denotes	[
T8500	2818-2820	CD	denotes	24
T8501	2820-2821	-RRB-	denotes	]
T8502	2821-2822	.	denotes	.
T8503	2822-2961	sentence	denotes	Since Atrxnull embryos appear to implant normally, lethality is likely to arise due to a failure of TGC function later during development.
T8504	2823-2828	IN	denotes	Since
T8505	2846-2852	VBP	denotes	appear
T8506	2829-2837	JJ	denotes	Atrxnull
T8507	2838-2845	NNS	denotes	embryos
T8508	2884-2886	VBZ	denotes	is
T8509	2853-2855	TO	denotes	to
T8510	2856-2863	VB	denotes	implant
T8511	2864-2872	RB	denotes	normally
T8512	2872-2874	,	denotes	,
T8513	2874-2883	NN	denotes	lethality
T8514	2887-2893	JJ	denotes	likely
T8515	2894-2896	TO	denotes	to
T8516	2897-2902	VB	denotes	arise
T8517	2903-2906	IN	denotes	due
T8518	2907-2909	IN	denotes	to
T8519	2910-2911	DT	denotes	a
T8520	2912-2919	NN	denotes	failure
T8521	2920-2922	IN	denotes	of
T8522	2923-2926	NN	denotes	TGC
T8523	2927-2935	NN	denotes	function
T8524	2936-2941	RB	denotes	later
T8525	2942-2948	IN	denotes	during
T8526	2949-2960	NN	denotes	development
T8527	2960-2961	.	denotes	.
T8528	2961-3114	sentence	denotes	Embryonic lethality in mice in the absence of Atrx was a surprising finding, as there had been no suggestion of foetal loss in the human ATR-X syndrome.
T8529	2962-2971	JJ	denotes	Embryonic
T8530	2972-2981	NN	denotes	lethality
T8531	3013-3016	VBD	denotes	was
T8532	2982-2984	IN	denotes	in
T8533	2985-2989	NNS	denotes	mice
T8534	2990-2992	IN	denotes	in
T8535	2993-2996	DT	denotes	the
T8536	2997-3004	NN	denotes	absence
T8537	3005-3007	IN	denotes	of
T8538	3008-3012	NN	denotes	Atrx
T8539	3017-3018	DT	denotes	a
T8540	3030-3037	NN	denotes	finding
T8541	3019-3029	JJ	denotes	surprising
T8542	3037-3039	,	denotes	,
T8543	3039-3041	IN	denotes	as
T8544	3052-3056	VBN	denotes	been
T8545	3042-3047	EX	denotes	there
T8546	3048-3051	VBD	denotes	had
T8547	3057-3059	DT	denotes	no
T8548	3060-3070	NN	denotes	suggestion
T8549	3071-3073	IN	denotes	of
T8550	3074-3080	JJ	denotes	foetal
T8551	3081-3085	NN	denotes	loss
T8552	3086-3088	IN	denotes	in
T8553	3089-3092	DT	denotes	the
T8554	3105-3113	NN	denotes	syndrome
T8555	3093-3098	JJ	denotes	human
T8556	3099-3102	NN	denotes	ATR
T8557	3103-3104	NN	denotes	X
T8558	3102-3103	HYPH	denotes	-
T8559	3113-3114	.	denotes	.
T8560	3114-3258	sentence	denotes	It is possible that the role of Atrx in the trophoblast is specific to mice and that ATRX has no role or is redundant in the human trophoblast.
T8561	3115-3117	PRP	denotes	It
T8562	3118-3120	VBZ	denotes	is
T8563	3121-3129	JJ	denotes	possible
T8564	3130-3134	IN	denotes	that
T8565	3171-3173	VBZ	denotes	is
T8566	3135-3138	DT	denotes	the
T8567	3139-3143	NN	denotes	role
T8568	3144-3146	IN	denotes	of
T8569	3147-3151	NN	denotes	Atrx
T8570	3152-3154	IN	denotes	in
T8571	3155-3158	DT	denotes	the
T8572	3159-3170	NN	denotes	trophoblast
T8573	3174-3182	JJ	denotes	specific
T8574	3183-3185	IN	denotes	to
T8575	3186-3190	NNS	denotes	mice
T8576	3191-3194	CC	denotes	and
T8577	3195-3199	IN	denotes	that
T8578	3205-3208	VBZ	denotes	has
T8579	3200-3204	NN	denotes	ATRX
T8580	3209-3211	DT	denotes	no
T8581	3212-3216	NN	denotes	role
T8582	3217-3219	CC	denotes	or
T8583	3220-3222	VBZ	denotes	is
T8584	3223-3232	JJ	denotes	redundant
T8585	3233-3235	IN	denotes	in
T8586	3236-3239	DT	denotes	the
T8587	3246-3257	NN	denotes	trophoblast
T8588	3240-3245	JJ	denotes	human
T8589	3257-3258	.	denotes	.
T8590	3258-3332	sentence	denotes	Indeed, the birth weight of babies with ATR-X syndrome is usually normal.
T8591	3259-3265	RB	denotes	Indeed
T8592	3314-3316	VBZ	denotes	is
T8593	3265-3267	,	denotes	,
T8594	3267-3270	DT	denotes	the
T8595	3277-3283	NN	denotes	weight
T8596	3271-3276	NN	denotes	birth
T8597	3284-3286	IN	denotes	of
T8598	3287-3293	NNS	denotes	babies
T8599	3294-3298	IN	denotes	with
T8600	3299-3302	NN	denotes	ATR
T8601	3303-3304	NN	denotes	X
T8602	3302-3303	HYPH	denotes	-
T8603	3305-3313	NN	denotes	syndrome
T8604	3317-3324	RB	denotes	usually
T8605	3325-3331	JJ	denotes	normal
T8606	3331-3332	.	denotes	.
T8607	3332-3539	sentence	denotes	An alternative explanation for the unexpectedly severe phenotype we observed in mice is that the Atrx Δ18Δneo deletion generated by Cre recombination completely ablates full-length Atrx protein (Figure 2E).
T8608	3333-3335	DT	denotes	An
T8609	3348-3359	NN	denotes	explanation
T8610	3336-3347	JJ	denotes	alternative
T8611	3418-3420	VBZ	denotes	is
T8612	3360-3363	IN	denotes	for
T8613	3364-3367	DT	denotes	the
T8614	3388-3397	NN	denotes	phenotype
T8615	3368-3380	RB	denotes	unexpectedly
T8616	3381-3387	JJ	denotes	severe
T8617	3398-3400	PRP	denotes	we
T8618	3401-3409	VBD	denotes	observed
T8619	3410-3412	IN	denotes	in
T8620	3413-3417	NNS	denotes	mice
T8621	3421-3425	IN	denotes	that
T8622	3494-3501	VBZ	denotes	ablates
T8623	3426-3429	DT	denotes	the
T8624	3443-3451	NN	denotes	deletion
T8625	3430-3442	NN	denotes	Atrx Δ18Δneo
T8626	3452-3461	VBN	denotes	generated
T8627	3462-3464	IN	denotes	by
T8628	3465-3468	NN	denotes	Cre
T8629	3469-3482	NN	denotes	recombination
T8630	3483-3493	RB	denotes	completely
T8631	3502-3506	JJ	denotes	full
T8632	3507-3513	NN	denotes	length
T8633	3506-3507	HYPH	denotes	-
T8634	3519-3526	NN	denotes	protein
T8635	3514-3518	NN	denotes	Atrx
T8636	3527-3528	-LRB-	denotes	(
T8637	3535-3537	NN	denotes	2E
T8638	3528-3534	NN	denotes	Figure
T8639	3537-3538	-RRB-	denotes	)
T8640	3538-3539	.	denotes	.
T8641	3539-3665	sentence	denotes	In contrast, all disease-causing mutations characterised in human ATR-X pedigrees appear to give rise to hypomorphic alleles.
T8642	3540-3542	IN	denotes	In
T8643	3622-3628	VBP	denotes	appear
T8644	3543-3551	NN	denotes	contrast
T8645	3551-3553	,	denotes	,
T8646	3553-3556	DT	denotes	all
T8647	3573-3582	NNS	denotes	mutations
T8648	3557-3564	NN	denotes	disease
T8649	3565-3572	VBG	denotes	causing
T8650	3564-3565	HYPH	denotes	-
T8651	3583-3596	VBN	denotes	characterised
T8652	3597-3599	IN	denotes	in
T8653	3600-3605	JJ	denotes	human
T8654	3612-3621	NNS	denotes	pedigrees
T8655	3606-3609	NN	denotes	ATR
T8656	3610-3611	NN	denotes	X
T8657	3609-3610	HYPH	denotes	-
T8658	3629-3631	TO	denotes	to
T8659	3632-3636	VB	denotes	give
T8660	3637-3641	NN	denotes	rise
T8661	3642-3644	IN	denotes	to
T8662	3645-3656	JJ	denotes	hypomorphic
T8663	3657-3664	NNS	denotes	alleles
T8664	3664-3665	.	denotes	.
T8665	3665-3985	sentence	denotes	Some full-length ATRX protein is detected in cases predicted to have truncating mutations (RJG, unpublished data), and residual ATPase activity in ATRX immunoprecipitates can be detected in Epstein-Barr virus-transformed lymphocytes of all human patients analysed to date (A. Argentaro and M. Mitson, unpublished data).
T8666	3666-3670	DT	denotes	Some
T8667	3688-3695	NN	denotes	protein
T8668	3671-3675	JJ	denotes	full
T8669	3676-3682	NN	denotes	length
T8670	3675-3676	HYPH	denotes	-
T8671	3683-3687	NN	denotes	ATRX
T8672	3699-3707	VBN	denotes	detected
T8673	3696-3698	VBZ	denotes	is
T8674	3708-3710	IN	denotes	in
T8675	3711-3716	NNS	denotes	cases
T8676	3717-3726	VBN	denotes	predicted
T8677	3727-3729	TO	denotes	to
T8678	3730-3734	VB	denotes	have
T8679	3735-3745	NN	denotes	truncating
T8680	3746-3755	NNS	denotes	mutations
T8681	3756-3757	-LRB-	denotes	(
T8682	3774-3778	NNS	denotes	data
T8683	3757-3760	NN	denotes	RJG
T8684	3760-3762	,	denotes	,
T8685	3762-3773	JJ	denotes	unpublished
T8686	3778-3779	-RRB-	denotes	)
T8687	3779-3781	,	denotes	,
T8688	3781-3784	CC	denotes	and
T8689	3785-3793	JJ	denotes	residual
T8690	3801-3809	NN	denotes	activity
T8691	3794-3800	NN	denotes	ATPase
T8692	3844-3852	VBN	denotes	detected
T8693	3810-3812	IN	denotes	in
T8694	3813-3817	NN	denotes	ATRX
T8695	3818-3836	NNS	denotes	immunoprecipitates
T8696	3837-3840	MD	denotes	can
T8697	3841-3843	VB	denotes	be
T8698	3853-3855	IN	denotes	in
T8699	3856-3863	NN	denotes	Epstein
T8700	3864-3868	NN	denotes	Barr
T8701	3863-3864	HYPH	denotes	-
T8702	3869-3874	NN	denotes	virus
T8703	3875-3886	VBN	denotes	transformed
T8704	3874-3875	HYPH	denotes	-
T8705	3887-3898	NNS	denotes	lymphocytes
T8706	3899-3901	IN	denotes	of
T8707	3902-3905	DT	denotes	all
T8708	3912-3920	NNS	denotes	patients
T8709	3906-3911	JJ	denotes	human
T8710	3921-3929	VBN	denotes	analysed
T8711	3930-3932	IN	denotes	to
T8712	3933-3937	NN	denotes	date
T8713	3938-3939	-LRB-	denotes	(
T8714	3939-3941	NNP	denotes	A.
T8715	3942-3951	NNP	denotes	Argentaro
T8716	3952-3955	CC	denotes	and
T8717	3956-3958	NNP	denotes	M.
T8718	3959-3965	NNP	denotes	Mitson
T8719	3965-3967	,	denotes	,
T8720	3967-3978	JJ	denotes	unpublished
T8721	3979-3983	NNS	denotes	data
T8722	3983-3984	-RRB-	denotes	)
T8723	3984-3985	.	denotes	.
T8724	3985-4175	sentence	denotes	The failure to observe a truly null ATRX allele among human patients strongly suggests that, as in the mouse, the complete absence of ATRX protein is incompatible with human fetal survival.
T8725	3986-3989	DT	denotes	The
T8726	3990-3997	NN	denotes	failure
T8727	4064-4072	VBZ	denotes	suggests
T8728	3998-4000	TO	denotes	to
T8729	4001-4008	VB	denotes	observe
T8730	4009-4010	DT	denotes	a
T8731	4027-4033	NN	denotes	allele
T8732	4011-4016	RB	denotes	truly
T8733	4017-4021	JJ	denotes	null
T8734	4022-4026	NN	denotes	ATRX
T8735	4034-4039	IN	denotes	among
T8736	4040-4045	JJ	denotes	human
T8737	4046-4054	NNS	denotes	patients
T8738	4055-4063	RB	denotes	strongly
T8739	4073-4077	IN	denotes	that
T8740	4133-4135	VBZ	denotes	is
T8741	4077-4079	,	denotes	,
T8742	4079-4081	IN	denotes	as
T8743	4082-4084	IN	denotes	in
T8744	4085-4088	DT	denotes	the
T8745	4089-4094	NN	denotes	mouse
T8746	4094-4096	,	denotes	,
T8747	4096-4099	DT	denotes	the
T8748	4109-4116	NN	denotes	absence
T8749	4100-4108	JJ	denotes	complete
T8750	4117-4119	IN	denotes	of
T8751	4120-4124	NN	denotes	ATRX
T8752	4125-4132	NN	denotes	protein
T8753	4136-4148	JJ	denotes	incompatible
T8754	4149-4153	IN	denotes	with
T8755	4154-4159	JJ	denotes	human
T8756	4166-4174	NN	denotes	survival
T8757	4160-4165	JJ	denotes	fetal
T8758	4174-4175	.	denotes	.
T8759	4175-4441	sentence	denotes	While this study has revealed an unexpected role for Atrx in the murine trophectoderm, as a result of the early lethality observed in Atrxnull embryos it is not possible to rule out other roles for Atrx at later developmental stages in tissues of the embryo proper.
T8760	4176-4181	IN	denotes	While
T8761	4197-4205	VBN	denotes	revealed
T8762	4182-4186	DT	denotes	this
T8763	4187-4192	NN	denotes	study
T8764	4193-4196	VBZ	denotes	has
T8765	4330-4332	VBZ	denotes	is
T8766	4206-4208	DT	denotes	an
T8767	4220-4224	NN	denotes	role
T8768	4209-4219	JJ	denotes	unexpected
T8769	4225-4228	IN	denotes	for
T8770	4229-4233	NN	denotes	Atrx
T8771	4234-4236	IN	denotes	in
T8772	4237-4240	DT	denotes	the
T8773	4248-4261	NN	denotes	trophectoderm
T8774	4241-4247	JJ	denotes	murine
T8775	4261-4263	,	denotes	,
T8776	4263-4265	IN	denotes	as
T8777	4266-4267	DT	denotes	a
T8778	4268-4274	NN	denotes	result
T8779	4275-4277	IN	denotes	of
T8780	4278-4281	DT	denotes	the
T8781	4288-4297	NN	denotes	lethality
T8782	4282-4287	JJ	denotes	early
T8783	4298-4306	VBN	denotes	observed
T8784	4307-4309	IN	denotes	in
T8785	4310-4318	JJ	denotes	Atrxnull
T8786	4319-4326	NNS	denotes	embryos
T8787	4327-4329	PRP	denotes	it
T8788	4333-4336	RB	denotes	not
T8789	4337-4345	JJ	denotes	possible
T8790	4346-4348	TO	denotes	to
T8791	4349-4353	VB	denotes	rule
T8792	4354-4357	RP	denotes	out
T8793	4358-4363	JJ	denotes	other
T8794	4364-4369	NNS	denotes	roles
T8795	4370-4373	IN	denotes	for
T8796	4374-4378	NN	denotes	Atrx
T8797	4379-4381	IN	denotes	at
T8798	4382-4387	JJ	denotes	later
T8799	4402-4408	NNS	denotes	stages
T8800	4388-4401	JJ	denotes	developmental
T8801	4409-4411	IN	denotes	in
T8802	4412-4419	NNS	denotes	tissues
T8803	4420-4422	IN	denotes	of
T8804	4423-4426	DT	denotes	the
T8805	4427-4433	NN	denotes	embryo
T8806	4434-4440	JJ	denotes	proper
T8807	4440-4441	.	denotes	.
T8808	4441-4652	sentence	denotes	Indeed, we show that Atrx is highly expressed throughout the entire developing embryo at 7.5 dpc (Figure 5B), and it is likely that Atrx function will turn out to be important for other differentiating tissues.
T8809	4442-4448	RB	denotes	Indeed
T8810	4453-4457	VBP	denotes	show
T8811	4448-4450	,	denotes	,
T8812	4450-4452	PRP	denotes	we
T8813	4458-4462	IN	denotes	that
T8814	4468-4470	VBZ	denotes	is
T8815	4463-4467	NN	denotes	Atrx
T8816	4471-4477	RB	denotes	highly
T8817	4478-4487	JJ	denotes	expressed
T8818	4488-4498	IN	denotes	throughout
T8819	4499-4502	DT	denotes	the
T8820	4521-4527	NN	denotes	embryo
T8821	4503-4509	JJ	denotes	entire
T8822	4510-4520	VBG	denotes	developing
T8823	4528-4530	IN	denotes	at
T8824	4531-4534	CD	denotes	7.5
T8825	4535-4538	NN	denotes	dpc
T8826	4539-4540	-LRB-	denotes	(
T8827	4547-4549	NN	denotes	5B
T8828	4540-4546	NN	denotes	Figure
T8829	4549-4550	-RRB-	denotes	)
T8830	4550-4552	,	denotes	,
T8831	4552-4555	CC	denotes	and
T8832	4556-4558	PRP	denotes	it
T8833	4559-4561	VBZ	denotes	is
T8834	4562-4568	JJ	denotes	likely
T8835	4569-4573	IN	denotes	that
T8836	4593-4597	VB	denotes	turn
T8837	4574-4578	NN	denotes	Atrx
T8838	4579-4587	NN	denotes	function
T8839	4588-4592	MD	denotes	will
T8840	4598-4601	RP	denotes	out
T8841	4602-4604	TO	denotes	to
T8842	4605-4607	VB	denotes	be
T8843	4608-4617	JJ	denotes	important
T8844	4618-4621	IN	denotes	for
T8845	4622-4627	JJ	denotes	other
T8846	4644-4651	NNS	denotes	tissues
T8847	4628-4643	VBG	denotes	differentiating
T8848	4651-4652	.	denotes	.
T8849	4652-4999	sentence	denotes	Tetraploid aggregation experiments (in which mutant embryos are rescued with wild-type extraembryonic tissues) might shed more light on the role of Atrx during later mouse development, but these issues can be more subtly dissected by combining the conditional Atrx flox allele that we have generated with different tissue-specific Cre transgenes.
T8850	4653-4663	NN	denotes	Tetraploid
T8851	4664-4675	NN	denotes	aggregation
T8852	4676-4687	NNS	denotes	experiments
T8853	4770-4774	VB	denotes	shed
T8854	4688-4689	-LRB-	denotes	(
T8855	4689-4691	IN	denotes	in
T8856	4717-4724	VBN	denotes	rescued
T8857	4692-4697	WDT	denotes	which
T8858	4698-4704	NN	denotes	mutant
T8859	4705-4712	NNS	denotes	embryos
T8860	4713-4716	VBP	denotes	are
T8861	4725-4729	IN	denotes	with
T8862	4730-4734	JJ	denotes	wild
T8863	4735-4739	NN	denotes	type
T8864	4734-4735	HYPH	denotes	-
T8865	4755-4762	NNS	denotes	tissues
T8866	4740-4754	JJ	denotes	extraembryonic
T8867	4762-4763	-RRB-	denotes	)
T8868	4764-4769	MD	denotes	might
T8869	4775-4779	JJR	denotes	more
T8870	4780-4785	NN	denotes	light
T8871	4786-4788	IN	denotes	on
T8872	4789-4792	DT	denotes	the
T8873	4793-4797	NN	denotes	role
T8874	4798-4800	IN	denotes	of
T8875	4801-4805	NN	denotes	Atrx
T8876	4806-4812	IN	denotes	during
T8877	4813-4818	JJ	denotes	later
T8878	4825-4836	NN	denotes	development
T8879	4819-4824	NN	denotes	mouse
T8880	4836-4838	,	denotes	,
T8881	4838-4841	CC	denotes	but
T8882	4842-4847	DT	denotes	these
T8883	4848-4854	NNS	denotes	issues
T8884	4874-4883	VBN	denotes	dissected
T8885	4855-4858	MD	denotes	can
T8886	4859-4861	VB	denotes	be
T8887	4862-4866	RBR	denotes	more
T8888	4867-4873	RB	denotes	subtly
T8889	4884-4886	IN	denotes	by
T8890	4887-4896	VBG	denotes	combining
T8891	4897-4900	DT	denotes	the
T8892	4923-4929	NN	denotes	allele
T8893	4901-4912	JJ	denotes	conditional
T8894	4913-4922	NN	denotes	Atrx flox
T8895	4930-4934	WDT	denotes	that
T8896	4943-4952	VBN	denotes	generated
T8897	4935-4937	PRP	denotes	we
T8898	4938-4942	VBP	denotes	have
T8899	4953-4957	IN	denotes	with
T8900	4958-4967	JJ	denotes	different
T8901	4988-4998	NNS	denotes	transgenes
T8902	4968-4974	NN	denotes	tissue
T8903	4975-4983	JJ	denotes	specific
T8904	4974-4975	HYPH	denotes	-
T8905	4984-4987	NN	denotes	Cre
T8906	4998-4999	.	denotes	.
T8907	4999-5131	sentence	denotes	As mentioned above, this approach has already revealed a critical role for Atrx during neuronal differentiation in adult mice [20].
T8908	5000-5002	IN	denotes	As
T8909	5003-5012	VBN	denotes	mentioned
T8910	5046-5054	VBN	denotes	revealed
T8911	5013-5018	RB	denotes	above
T8912	5018-5020	,	denotes	,
T8913	5020-5024	DT	denotes	this
T8914	5025-5033	NN	denotes	approach
T8915	5034-5037	VBZ	denotes	has
T8916	5038-5045	RB	denotes	already
T8917	5055-5056	DT	denotes	a
T8918	5066-5070	NN	denotes	role
T8919	5057-5065	JJ	denotes	critical
T8920	5071-5074	IN	denotes	for
T8921	5075-5079	NN	denotes	Atrx
T8922	5080-5086	IN	denotes	during
T8923	5087-5095	JJ	denotes	neuronal
T8924	5096-5111	NN	denotes	differentiation
T8925	5112-5114	IN	denotes	in
T8926	5115-5120	JJ	denotes	adult
T8927	5121-5125	NNS	denotes	mice
T8928	5126-5127	-LRB-	denotes	[
T8929	5127-5129	CD	denotes	20
T8930	5129-5130	-RRB-	denotes	]
T8931	5130-5131	.	denotes	.
T8932	5131-5489	sentence	denotes	Further evidence that Atrx is also required at later stages of mouse development is provided by the observed dramatic skewing against Atrx-negative cells in some somatic tissues of carrier female mice, whose tissues initially comprise a mosaic of Atrx-positive and Atrx-negative cells as a result of random X-inactivation (M. Muers, personal communication).
T8933	5132-5139	JJ	denotes	Further
T8934	5140-5148	NN	denotes	evidence
T8935	5216-5224	VBN	denotes	provided
T8936	5149-5153	IN	denotes	that
T8937	5167-5175	VBN	denotes	required
T8938	5154-5158	NN	denotes	Atrx
T8939	5159-5161	VBZ	denotes	is
T8940	5162-5166	RB	denotes	also
T8941	5176-5178	IN	denotes	at
T8942	5179-5184	JJ	denotes	later
T8943	5185-5191	NNS	denotes	stages
T8944	5192-5194	IN	denotes	of
T8945	5195-5200	NN	denotes	mouse
T8946	5201-5212	NN	denotes	development
T8947	5213-5215	VBZ	denotes	is
T8948	5225-5227	IN	denotes	by
T8949	5228-5231	DT	denotes	the
T8950	5250-5257	NN	denotes	skewing
T8951	5232-5240	VBN	denotes	observed
T8952	5241-5249	JJ	denotes	dramatic
T8953	5258-5265	IN	denotes	against
T8954	5266-5270	NN	denotes	Atrx
T8955	5280-5285	NNS	denotes	cells
T8956	5270-5271	HYPH	denotes	-
T8957	5271-5279	JJ	denotes	negative
T8958	5286-5288	IN	denotes	in
T8959	5289-5293	DT	denotes	some
T8960	5302-5309	NNS	denotes	tissues
T8961	5294-5301	JJ	denotes	somatic
T8962	5310-5312	IN	denotes	of
T8963	5313-5320	NN	denotes	carrier
T8964	5328-5332	NNS	denotes	mice
T8965	5321-5327	JJ	denotes	female
T8966	5332-5334	,	denotes	,
T8967	5334-5339	WP$	denotes	whose
T8968	5340-5347	NNS	denotes	tissues
T8969	5358-5366	VBP	denotes	comprise
T8970	5348-5357	RB	denotes	initially
T8971	5367-5368	DT	denotes	a
T8972	5369-5375	NN	denotes	mosaic
T8973	5376-5378	IN	denotes	of
T8974	5379-5383	NN	denotes	Atrx
T8975	5384-5392	JJ	denotes	positive
T8976	5383-5384	HYPH	denotes	-
T8977	5411-5416	NNS	denotes	cells
T8978	5393-5396	CC	denotes	and
T8979	5397-5401	NN	denotes	Atrx
T8980	5402-5410	JJ	denotes	negative
T8981	5401-5402	HYPH	denotes	-
T8982	5417-5419	IN	denotes	as
T8983	5420-5421	DT	denotes	a
T8984	5422-5428	NN	denotes	result
T8985	5429-5431	IN	denotes	of
T8986	5432-5438	JJ	denotes	random
T8987	5441-5453	NN	denotes	inactivation
T8988	5439-5440	NN	denotes	X
T8989	5440-5441	HYPH	denotes	-
T8990	5454-5455	-LRB-	denotes	(
T8991	5455-5457	NNP	denotes	M.
T8992	5458-5463	NNP	denotes	Muers
T8993	5463-5465	,	denotes	,
T8994	5465-5473	JJ	denotes	personal
T8995	5474-5487	NN	denotes	communication
T8996	5487-5488	-RRB-	denotes	)
T8997	5488-5489	.	denotes	.
T8998	5489-5676	sentence	denotes	Atrx joins an expanding list of mouse genes for which targeted disruption results in peri-implantation lethality as a result of trophoblast or placental abnormalities (reviewed in [25]).
T8999	5490-5494	NN	denotes	Atrx
T9000	5495-5500	VBZ	denotes	joins
T9001	5501-5503	DT	denotes	an
T9002	5514-5518	NN	denotes	list
T9003	5504-5513	VBG	denotes	expanding
T9004	5519-5521	IN	denotes	of
T9005	5522-5527	NN	denotes	mouse
T9006	5528-5533	NNS	denotes	genes
T9007	5534-5537	IN	denotes	for
T9008	5564-5571	VBZ	denotes	results
T9009	5538-5543	WDT	denotes	which
T9010	5544-5552	VBN	denotes	targeted
T9011	5553-5563	NN	denotes	disruption
T9012	5572-5574	IN	denotes	in
T9013	5575-5592	JJ	denotes	peri-implantation
T9014	5593-5602	NN	denotes	lethality
T9015	5603-5605	IN	denotes	as
T9016	5606-5607	DT	denotes	a
T9017	5608-5614	NN	denotes	result
T9018	5615-5617	IN	denotes	of
T9019	5618-5629	NN	denotes	trophoblast
T9020	5643-5656	NNS	denotes	abnormalities
T9021	5630-5632	CC	denotes	or
T9022	5633-5642	JJ	denotes	placental
T9023	5657-5658	-LRB-	denotes	(
T9024	5658-5666	VBN	denotes	reviewed
T9025	5667-5669	IN	denotes	in
T9026	5670-5671	-LRB-	denotes	[
T9027	5671-5673	CD	denotes	25
T9028	5673-5674	-RRB-	denotes	]
T9029	5674-5675	-RRB-	denotes	)
T9030	5675-5676	.	denotes	.
T9031	5676-5786	sentence	denotes	Comparison with other phenotypes might provide some insight into the role of Atrx in trophoblast development.
T9032	5677-5687	NN	denotes	Comparison
T9033	5716-5723	VB	denotes	provide
T9034	5688-5692	IN	denotes	with
T9035	5693-5698	JJ	denotes	other
T9036	5699-5709	NNS	denotes	phenotypes
T9037	5710-5715	MD	denotes	might
T9038	5724-5728	DT	denotes	some
T9039	5729-5736	NN	denotes	insight
T9040	5737-5741	IN	denotes	into
T9041	5742-5745	DT	denotes	the
T9042	5746-5750	NN	denotes	role
T9043	5751-5753	IN	denotes	of
T9044	5754-5758	NN	denotes	Atrx
T9045	5759-5761	IN	denotes	in
T9046	5762-5773	NN	denotes	trophoblast
T9047	5774-5785	NN	denotes	development
T9048	5785-5786	.	denotes	.
T9049	5786-6002	sentence	denotes	Atrx-mutant embryos progress further than embryos nullizygous for factors involved in the initial specification of trophoblast stem cells (such as Cdx2) or in stem cell maintenance and proliferation (such as Eomes).
T9050	5787-5791	NN	denotes	Atrx
T9051	5792-5798	NN	denotes	mutant
T9052	5791-5792	HYPH	denotes	-
T9053	5799-5806	NNS	denotes	embryos
T9054	5807-5815	VBP	denotes	progress
T9055	5816-5823	RB	denotes	further
T9056	5824-5828	IN	denotes	than
T9057	5829-5836	NNS	denotes	embryos
T9058	5837-5848	JJ	denotes	nullizygous
T9059	5849-5852	IN	denotes	for
T9060	5853-5860	NNS	denotes	factors
T9061	5861-5869	VBN	denotes	involved
T9062	5870-5872	IN	denotes	in
T9063	5873-5876	DT	denotes	the
T9064	5885-5898	NN	denotes	specification
T9065	5877-5884	JJ	denotes	initial
T9066	5899-5901	IN	denotes	of
T9067	5902-5913	NN	denotes	trophoblast
T9068	5919-5924	NNS	denotes	cells
T9069	5914-5918	NN	denotes	stem
T9070	5925-5926	-LRB-	denotes	(
T9071	5931-5933	IN	denotes	as
T9072	5926-5930	JJ	denotes	such
T9073	5934-5938	NN	denotes	Cdx2
T9074	5938-5939	-RRB-	denotes	)
T9075	5940-5942	CC	denotes	or
T9076	5943-5945	IN	denotes	in
T9077	5946-5950	NN	denotes	stem
T9078	5956-5967	NN	denotes	maintenance
T9079	5951-5955	NN	denotes	cell
T9080	5968-5971	CC	denotes	and
T9081	5972-5985	NN	denotes	proliferation
T9082	5986-5987	-LRB-	denotes	(
T9083	5992-5994	IN	denotes	as
T9084	5987-5991	JJ	denotes	such
T9085	5995-6000	NN	denotes	Eomes
T9086	6000-6001	-RRB-	denotes	)
T9087	6001-6002	.	denotes	.
T9088	6002-6238	sentence	denotes	Cdx2-mutant embryos fail to implant and die between 3.5 and 5.5 dpc [26], while Eomes-mutant blastocysts implant into the uterus, but arrest soon after implantation without forming organised embryonic or extraembryonic structures [27].
T9089	6003-6007	NN	denotes	Cdx2
T9090	6008-6014	NN	denotes	mutant
T9091	6007-6008	HYPH	denotes	-
T9092	6015-6022	NNS	denotes	embryos
T9093	6023-6027	VBP	denotes	fail
T9094	6028-6030	TO	denotes	to
T9095	6031-6038	VB	denotes	implant
T9096	6039-6042	CC	denotes	and
T9097	6043-6046	VBP	denotes	die
T9098	6047-6054	IN	denotes	between
T9099	6055-6058	CD	denotes	3.5
T9100	6067-6070	NN	denotes	dpc
T9101	6059-6062	CC	denotes	and
T9102	6063-6066	CD	denotes	5.5
T9103	6071-6072	-LRB-	denotes	[
T9104	6072-6074	CD	denotes	26
T9105	6074-6075	-RRB-	denotes	]
T9106	6075-6077	,	denotes	,
T9107	6077-6082	IN	denotes	while
T9108	6108-6115	VBP	denotes	implant
T9109	6083-6088	NN	denotes	Eomes
T9110	6089-6095	NN	denotes	mutant
T9111	6088-6089	HYPH	denotes	-
T9112	6096-6107	NNS	denotes	blastocysts
T9113	6116-6120	IN	denotes	into
T9114	6121-6124	DT	denotes	the
T9115	6125-6131	NN	denotes	uterus
T9116	6131-6133	,	denotes	,
T9117	6133-6136	CC	denotes	but
T9118	6137-6143	VBP	denotes	arrest
T9119	6144-6148	RB	denotes	soon
T9120	6149-6154	IN	denotes	after
T9121	6155-6167	NN	denotes	implantation
T9122	6168-6175	IN	denotes	without
T9123	6176-6183	VBG	denotes	forming
T9124	6184-6193	VBN	denotes	organised
T9125	6222-6232	NNS	denotes	structures
T9126	6194-6203	JJ	denotes	embryonic
T9127	6204-6206	CC	denotes	or
T9128	6207-6221	JJ	denotes	extraembryonic
T9129	6233-6234	-LRB-	denotes	[
T9130	6234-6236	CD	denotes	27
T9131	6236-6237	-RRB-	denotes	]
T9132	6237-6238	.	denotes	.
T9133	6238-6349	sentence	denotes	In contrast, Atrx-mutant embryos implant successfully and establish organised embryonic structures by 7.5 dpc.
T9134	6239-6241	IN	denotes	In
T9135	6272-6279	VBP	denotes	implant
T9136	6242-6250	NN	denotes	contrast
T9137	6250-6252	,	denotes	,
T9138	6252-6256	NN	denotes	Atrx
T9139	6257-6263	NN	denotes	mutant
T9140	6256-6257	HYPH	denotes	-
T9141	6264-6271	NNS	denotes	embryos
T9142	6280-6292	RB	denotes	successfully
T9143	6293-6296	CC	denotes	and
T9144	6297-6306	VBP	denotes	establish
T9145	6307-6316	VBN	denotes	organised
T9146	6327-6337	NNS	denotes	structures
T9147	6317-6326	JJ	denotes	embryonic
T9148	6338-6340	IN	denotes	by
T9149	6341-6344	CD	denotes	7.5
T9150	6345-6348	NN	denotes	dpc
T9151	6348-6349	.	denotes	.
T9152	6349-6486	sentence	denotes	The Atrx-mutant phenotype closely resembles that observed in mice nullizygous for the basic helix-loop-helix transcription factor Hand1.
T9153	6350-6353	DT	denotes	The
T9154	6366-6375	NN	denotes	phenotype
T9155	6354-6358	NN	denotes	Atrx
T9156	6359-6365	NN	denotes	mutant
T9157	6358-6359	HYPH	denotes	-
T9158	6384-6393	VBZ	denotes	resembles
T9159	6376-6383	RB	denotes	closely
T9160	6394-6398	DT	denotes	that
T9161	6399-6407	VBN	denotes	observed
T9162	6408-6410	IN	denotes	in
T9163	6411-6415	NNS	denotes	mice
T9164	6416-6427	JJ	denotes	nullizygous
T9165	6428-6431	IN	denotes	for
T9166	6432-6435	DT	denotes	the
T9167	6473-6479	NN	denotes	factor
T9168	6436-6441	JJ	denotes	basic
T9169	6442-6447	NN	denotes	helix
T9170	6453-6458	NN	denotes	helix
T9171	6447-6448	HYPH	denotes	-
T9172	6448-6452	NN	denotes	loop
T9173	6452-6453	HYPH	denotes	-
T9174	6459-6472	NN	denotes	transcription
T9175	6480-6485	NN	denotes	Hand1
T9176	6485-6486	.	denotes	.
T9177	6486-6712	sentence	denotes	Hand1-mutant conceptuses arrest at around 7.5 dpc and display a normal embryonic compartment, but, like Atrx-mutant embryos, ablation of Hand1 causes a reduction in the size of the ectoplacental cone and density of TGCs [28].
T9178	6487-6492	NN	denotes	Hand1
T9179	6493-6499	NN	denotes	mutant
T9180	6492-6493	HYPH	denotes	-
T9181	6500-6511	NNS	denotes	conceptuses
T9182	6512-6518	VBP	denotes	arrest
T9183	6519-6521	IN	denotes	at
T9184	6522-6528	IN	denotes	around
T9185	6529-6532	CD	denotes	7.5
T9186	6533-6536	NN	denotes	dpc
T9187	6537-6540	CC	denotes	and
T9188	6541-6548	VBP	denotes	display
T9189	6549-6550	DT	denotes	a
T9190	6568-6579	NN	denotes	compartment
T9191	6551-6557	JJ	denotes	normal
T9192	6558-6567	JJ	denotes	embryonic
T9193	6579-6581	,	denotes	,
T9194	6581-6584	CC	denotes	but
T9195	6584-6586	,	denotes	,
T9196	6586-6590	IN	denotes	like
T9197	6630-6636	VBZ	denotes	causes
T9198	6591-6595	NN	denotes	Atrx
T9199	6596-6602	NN	denotes	mutant
T9200	6595-6596	HYPH	denotes	-
T9201	6603-6610	NNS	denotes	embryos
T9202	6610-6612	,	denotes	,
T9203	6612-6620	NN	denotes	ablation
T9204	6621-6623	IN	denotes	of
T9205	6624-6629	NN	denotes	Hand1
T9206	6637-6638	DT	denotes	a
T9207	6639-6648	NN	denotes	reduction
T9208	6649-6651	IN	denotes	in
T9209	6652-6655	DT	denotes	the
T9210	6656-6660	NN	denotes	size
T9211	6661-6663	IN	denotes	of
T9212	6664-6667	DT	denotes	the
T9213	6682-6686	NN	denotes	cone
T9214	6668-6681	JJ	denotes	ectoplacental
T9215	6687-6690	CC	denotes	and
T9216	6691-6698	NN	denotes	density
T9217	6699-6701	IN	denotes	of
T9218	6702-6706	NNS	denotes	TGCs
T9219	6707-6708	-LRB-	denotes	[
T9220	6708-6710	CD	denotes	28
T9221	6710-6711	-RRB-	denotes	]
T9222	6711-6712	.	denotes	.
T9223	6712-6815	sentence	denotes	As with Atrx mutants, only arrested or resorbed Hand1-mutant conceptuses were recovered after 8.5 dpc.
T9224	6713-6715	IN	denotes	As
T9225	6791-6800	VBN	denotes	recovered
T9226	6716-6720	IN	denotes	with
T9227	6721-6725	NN	denotes	Atrx
T9228	6726-6733	NNS	denotes	mutants
T9229	6733-6735	,	denotes	,
T9230	6735-6739	RB	denotes	only
T9231	6774-6785	NNS	denotes	conceptuses
T9232	6740-6748	VBN	denotes	arrested
T9233	6749-6751	CC	denotes	or
T9234	6752-6760	VBN	denotes	resorbed
T9235	6761-6766	NN	denotes	Hand1
T9236	6767-6773	NN	denotes	mutant
T9237	6766-6767	HYPH	denotes	-
T9238	6786-6790	VBD	denotes	were
T9239	6801-6806	IN	denotes	after
T9240	6807-6810	CD	denotes	8.5
T9241	6811-6814	NN	denotes	dpc
T9242	6814-6815	.	denotes	.
T9243	6815-6973	sentence	denotes	Also like Atrx, disruption of Hand1 specifically affects secondary giant cell formation, and primary trophoblast outgrowths from blastocysts appeared normal.
T9244	6816-6820	RB	denotes	Also
T9245	6865-6872	VBZ	denotes	affects
T9246	6821-6825	IN	denotes	like
T9247	6826-6830	NN	denotes	Atrx
T9248	6830-6832	,	denotes	,
T9249	6832-6842	NN	denotes	disruption
T9250	6843-6845	IN	denotes	of
T9251	6846-6851	NN	denotes	Hand1
T9252	6852-6864	RB	denotes	specifically
T9253	6873-6882	JJ	denotes	secondary
T9254	6889-6893	NN	denotes	cell
T9255	6883-6888	JJ	denotes	giant
T9256	6894-6903	NN	denotes	formation
T9257	6903-6905	,	denotes	,
T9258	6905-6908	CC	denotes	and
T9259	6909-6916	JJ	denotes	primary
T9260	6929-6939	NNS	denotes	outgrowths
T9261	6917-6928	NN	denotes	trophoblast
T9262	6957-6965	VBD	denotes	appeared
T9263	6940-6944	IN	denotes	from
T9264	6945-6956	NNS	denotes	blastocysts
T9265	6966-6972	JJ	denotes	normal
T9266	6972-6973	.	denotes	.
T9267	6973-7139	sentence	denotes	Hand1 is required for terminal differentiation of secondary TGCs, and in its absence trophoblast cells arrest at a precursor stage in the ectoplacental cone [17,28].
T9268	6974-6979	NN	denotes	Hand1
T9269	6983-6991	VBN	denotes	required
T9270	6980-6982	VBZ	denotes	is
T9271	6992-6995	IN	denotes	for
T9272	6996-7004	JJ	denotes	terminal
T9273	7005-7020	NN	denotes	differentiation
T9274	7021-7023	IN	denotes	of
T9275	7024-7033	JJ	denotes	secondary
T9276	7034-7038	NNS	denotes	TGCs
T9277	7038-7040	,	denotes	,
T9278	7040-7043	CC	denotes	and
T9279	7044-7046	IN	denotes	in
T9280	7077-7083	VBP	denotes	arrest
T9281	7047-7050	PRP$	denotes	its
T9282	7051-7058	NN	denotes	absence
T9283	7059-7070	NN	denotes	trophoblast
T9284	7071-7076	NNS	denotes	cells
T9285	7084-7086	IN	denotes	at
T9286	7087-7088	DT	denotes	a
T9287	7099-7104	NN	denotes	stage
T9288	7089-7098	NN	denotes	precursor
T9289	7105-7107	IN	denotes	in
T9290	7108-7111	DT	denotes	the
T9291	7126-7130	NN	denotes	cone
T9292	7112-7125	JJ	denotes	ectoplacental
T9293	7131-7132	-LRB-	denotes	[
T9294	7135-7137	CD	denotes	28
T9295	7132-7134	CD	denotes	17
T9296	7134-7135	,	denotes	,
T9297	7137-7138	-RRB-	denotes	]
T9298	7138-7139	.	denotes	.
T9299	7139-7510	sentence	denotes	Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as a co-regulator of one or more of the downstream transcriptional targets of Hand1.
T9300	7140-7145	VBN	denotes	Given
T9301	7309-7311	VB	denotes	be
T9302	7146-7149	DT	denotes	the
T9303	7150-7160	NN	denotes	similarity
T9304	7161-7163	IN	denotes	of
T9305	7164-7167	DT	denotes	the
T9306	7191-7201	NNS	denotes	phenotypes
T9307	7168-7172	NN	denotes	Atrx
T9308	7184-7190	NN	denotes	mutant
T9309	7172-7173	HYPH	denotes	-
T9310	7174-7177	CC	denotes	and
T9311	7178-7183	NN	denotes	Hand1
T9312	7183-7184	HYPH	denotes	-
T9313	7202-7205	CC	denotes	and
T9314	7206-7209	DT	denotes	the
T9315	7210-7220	NN	denotes	likelihood
T9316	7221-7225	IN	denotes	that
T9317	7231-7235	VBZ	denotes	acts
T9318	7226-7230	NN	denotes	Atrx
T9319	7236-7238	IN	denotes	as
T9320	7239-7240	DT	denotes	a
T9321	7257-7266	NN	denotes	regulator
T9322	7241-7256	JJ	denotes	transcriptional
T9323	7267-7269	IN	denotes	by
T9324	7270-7279	VBG	denotes	modifying
T9325	7280-7289	NN	denotes	chromatin
T9326	7290-7299	NN	denotes	structure
T9327	7299-7301	,	denotes	,
T9328	7301-7303	PRP	denotes	it
T9329	7304-7308	MD	denotes	will
T9330	7312-7314	IN	denotes	of
T9331	7315-7323	NN	denotes	interest
T9332	7324-7326	TO	denotes	to
T9333	7327-7336	VB	denotes	determine
T9334	7337-7344	IN	denotes	whether
T9335	7350-7352	VBZ	denotes	is
T9336	7345-7349	NN	denotes	Atrx
T9337	7353-7359	PRP	denotes	itself
T9338	7360-7361	DT	denotes	a
T9339	7362-7371	NN	denotes	regulator
T9340	7372-7374	IN	denotes	of
T9341	7375-7380	NN	denotes	Hand1
T9342	7381-7391	NN	denotes	expression
T9343	7391-7393	,	denotes	,
T9344	7393-7395	CC	denotes	or
T9345	7396-7409	RB	denotes	alternatively
T9346	7421-7425	VBZ	denotes	acts
T9347	7410-7417	IN	denotes	whether
T9348	7418-7420	PRP	denotes	it
T9349	7426-7428	IN	denotes	as
T9350	7429-7430	DT	denotes	a
T9351	7431-7443	NN	denotes	co-regulator
T9352	7444-7446	IN	denotes	of
T9353	7447-7450	CD	denotes	one
T9354	7451-7453	CC	denotes	or
T9355	7454-7458	JJR	denotes	more
T9356	7459-7461	IN	denotes	of
T9357	7462-7465	DT	denotes	the
T9358	7493-7500	NNS	denotes	targets
T9359	7466-7476	JJ	denotes	downstream
T9360	7477-7492	JJ	denotes	transcriptional
T9361	7501-7503	IN	denotes	of
T9362	7504-7509	NN	denotes	Hand1
T9363	7509-7510	.	denotes	.
T9364	7510-7643	sentence	denotes	It is noteworthy that, in the brain-specific Atrx knockout mice, the defect was observed in terminally differentiating neurons [20].
T9365	7511-7513	PRP	denotes	It
T9366	7514-7516	VBZ	denotes	is
T9367	7517-7527	JJ	denotes	noteworthy
T9368	7528-7532	IN	denotes	that
T9369	7591-7599	VBN	denotes	observed
T9370	7532-7534	,	denotes	,
T9371	7534-7536	IN	denotes	in
T9372	7537-7540	DT	denotes	the
T9373	7570-7574	NNS	denotes	mice
T9374	7541-7546	NN	denotes	brain
T9375	7547-7555	JJ	denotes	specific
T9376	7546-7547	HYPH	denotes	-
T9377	7556-7560	NN	denotes	Atrx
T9378	7561-7569	NN	denotes	knockout
T9379	7574-7576	,	denotes	,
T9380	7576-7579	DT	denotes	the
T9381	7580-7586	NN	denotes	defect
T9382	7587-7590	VBD	denotes	was
T9383	7600-7602	IN	denotes	in
T9384	7603-7613	RB	denotes	terminally
T9385	7614-7629	VBG	denotes	differentiating
T9386	7630-7637	NNS	denotes	neurons
T9387	7638-7639	-LRB-	denotes	[
T9388	7639-7641	CD	denotes	20
T9389	7641-7642	-RRB-	denotes	]
T9390	7642-7643	.	denotes	.
T9391	7643-7952	sentence	denotes	The secondary TGCs affected in the universal Atrx knockout reported here represent one of the first terminally differentiated tissues in the developing mouse, and this may point to the requirement for Atrx in the high-level expression of some tissue-specific genes during the final stages of differentiation.
T9392	7644-7647	DT	denotes	The
T9393	7658-7662	NNS	denotes	TGCs
T9394	7648-7657	JJ	denotes	secondary
T9395	7717-7726	VBP	denotes	represent
T9396	7663-7671	VBN	denotes	affected
T9397	7672-7674	IN	denotes	in
T9398	7675-7678	DT	denotes	the
T9399	7694-7702	NN	denotes	knockout
T9400	7679-7688	JJ	denotes	universal
T9401	7689-7693	NN	denotes	Atrx
T9402	7703-7711	VBN	denotes	reported
T9403	7712-7716	RB	denotes	here
T9404	7727-7730	CD	denotes	one
T9405	7731-7733	IN	denotes	of
T9406	7734-7737	DT	denotes	the
T9407	7770-7777	NNS	denotes	tissues
T9408	7738-7743	JJ	denotes	first
T9409	7744-7754	RB	denotes	terminally
T9410	7755-7769	VBN	denotes	differentiated
T9411	7778-7780	IN	denotes	in
T9412	7781-7784	DT	denotes	the
T9413	7796-7801	NN	denotes	mouse
T9414	7785-7795	VBG	denotes	developing
T9415	7801-7803	,	denotes	,
T9416	7803-7806	CC	denotes	and
T9417	7807-7811	DT	denotes	this
T9418	7816-7821	VB	denotes	point
T9419	7812-7815	MD	denotes	may
T9420	7822-7824	IN	denotes	to
T9421	7825-7828	DT	denotes	the
T9422	7829-7840	NN	denotes	requirement
T9423	7841-7844	IN	denotes	for
T9424	7845-7849	NN	denotes	Atrx
T9425	7850-7852	IN	denotes	in
T9426	7853-7856	DT	denotes	the
T9427	7868-7878	NN	denotes	expression
T9428	7857-7861	JJ	denotes	high
T9429	7862-7867	NN	denotes	level
T9430	7861-7862	HYPH	denotes	-
T9431	7879-7881	IN	denotes	of
T9432	7882-7886	DT	denotes	some
T9433	7903-7908	NNS	denotes	genes
T9434	7887-7893	NN	denotes	tissue
T9435	7894-7902	JJ	denotes	specific
T9436	7893-7894	HYPH	denotes	-
T9437	7909-7915	IN	denotes	during
T9438	7916-7919	DT	denotes	the
T9439	7926-7932	NNS	denotes	stages
T9440	7920-7925	JJ	denotes	final
T9441	7933-7935	IN	denotes	of
T9442	7936-7951	NN	denotes	differentiation
T9443	7951-7952	.	denotes	.
T9444	7952-8160	sentence	denotes	Interestingly, the α-globin genes, the only confirmed transcriptional targets of regulation by human ATRX, are also highly expressed specifically during terminal differentiation within the erythroid lineage.
T9445	7953-7966	RB	denotes	Interestingly
T9446	8076-8085	VBN	denotes	expressed
T9447	7966-7968	,	denotes	,
T9448	7968-7971	DT	denotes	the
T9449	7981-7986	NNS	denotes	genes
T9450	7972-7973	NN	denotes	α
T9451	7974-7980	NN	denotes	globin
T9452	7973-7974	HYPH	denotes	-
T9453	7986-7988	,	denotes	,
T9454	7988-7991	DT	denotes	the
T9455	8023-8030	NNS	denotes	targets
T9456	7992-7996	RB	denotes	only
T9457	7997-8006	VBN	denotes	confirmed
T9458	8007-8022	JJ	denotes	transcriptional
T9459	8031-8033	IN	denotes	of
T9460	8034-8044	NN	denotes	regulation
T9461	8045-8047	IN	denotes	by
T9462	8048-8053	JJ	denotes	human
T9463	8054-8058	NN	denotes	ATRX
T9464	8058-8060	,	denotes	,
T9465	8060-8063	VBP	denotes	are
T9466	8064-8068	RB	denotes	also
T9467	8069-8075	RB	denotes	highly
T9468	8086-8098	RB	denotes	specifically
T9469	8099-8105	IN	denotes	during
T9470	8106-8114	JJ	denotes	terminal
T9471	8115-8130	NN	denotes	differentiation
T9472	8131-8137	IN	denotes	within
T9473	8138-8141	DT	denotes	the
T9474	8152-8159	NN	denotes	lineage
T9475	8142-8151	JJ	denotes	erythroid
T9476	8159-8160	.	denotes	.
T9932	8162-8166	NN	denotes	Atrx
T9933	8167-8174	VBZ	denotes	Escapes
T9934	8175-8184	VBN	denotes	Imprinted
T9935	8187-8199	NN	denotes	Inactivation
T9936	8185-8186	NN	denotes	X
T9937	8186-8187	HYPH	denotes	-
T9938	8200-8202	IN	denotes	in
T9939	8203-8217	JJ	denotes	Extraembryonic
T9940	8218-8225	NNS	denotes	Tissues
T9941	8226-8228	IN	denotes	of
T9942	8229-8236	NN	denotes	Carrier
T9943	8244-8248	NNS	denotes	Mice
T9944	8237-8243	JJ	denotes	Female
T9945	8248-8531	sentence	denotes	Another surprising finding of this study is that, in carrier female embryos, a paternally inherited Atrx WT allele appears to escape the process of imprinted X-inactivation, which ordinarily silences the Xp chromosome in the extraembryonic compartment of female murine tissues [18].
T9946	8249-8256	DT	denotes	Another
T9947	8268-8275	NN	denotes	finding
T9948	8257-8267	JJ	denotes	surprising
T9949	8290-8292	VBZ	denotes	is
T9950	8276-8278	IN	denotes	of
T9951	8279-8283	DT	denotes	this
T9952	8284-8289	NN	denotes	study
T9953	8293-8297	IN	denotes	that
T9954	8364-8371	VBZ	denotes	appears
T9955	8297-8299	,	denotes	,
T9956	8299-8301	IN	denotes	in
T9957	8302-8309	NN	denotes	carrier
T9958	8317-8324	NNS	denotes	embryos
T9959	8310-8316	JJ	denotes	female
T9960	8324-8326	,	denotes	,
T9961	8326-8327	DT	denotes	a
T9962	8357-8363	NN	denotes	allele
T9963	8328-8338	RB	denotes	paternally
T9964	8339-8348	VBN	denotes	inherited
T9965	8349-8356	NN	denotes	Atrx WT
T9966	8372-8374	TO	denotes	to
T9967	8375-8381	VB	denotes	escape
T9968	8382-8385	DT	denotes	the
T9969	8386-8393	NN	denotes	process
T9970	8394-8396	IN	denotes	of
T9971	8397-8406	VBN	denotes	imprinted
T9972	8409-8421	NN	denotes	inactivation
T9973	8407-8408	NN	denotes	X
T9974	8408-8409	HYPH	denotes	-
T9975	8421-8423	,	denotes	,
T9976	8423-8428	WDT	denotes	which
T9977	8440-8448	VBZ	denotes	silences
T9978	8429-8439	RB	denotes	ordinarily
T9979	8449-8452	DT	denotes	the
T9980	8456-8466	NN	denotes	chromosome
T9981	8453-8455	NN	denotes	Xp
T9982	8467-8469	IN	denotes	in
T9983	8470-8473	DT	denotes	the
T9984	8489-8500	NN	denotes	compartment
T9985	8474-8488	JJ	denotes	extraembryonic
T9986	8501-8503	IN	denotes	of
T9987	8504-8510	JJ	denotes	female
T9988	8518-8525	NNS	denotes	tissues
T9989	8511-8517	JJ	denotes	murine
T9990	8526-8527	-LRB-	denotes	[
T9991	8527-8529	CD	denotes	18
T9992	8529-8530	-RRB-	denotes	]
T9993	8530-8531	.	denotes	.
T9994	8531-8715	sentence	denotes	Silencing of the Atrx WT allele on Xp should render these females null for Atrx in the extraembryonic tissues, since the normally active Xm chromosome carries the Atrx Δ18Δneo allele.
T9995	8532-8541	NN	denotes	Silencing
T9996	8577-8583	VB	denotes	render
T9997	8542-8544	IN	denotes	of
T9998	8545-8548	DT	denotes	the
T9999	8557-8563	NN	denotes	allele
T10000	8549-8556	NN	denotes	Atrx WT
T10001	8564-8566	IN	denotes	on
T10002	8567-8569	NN	denotes	Xp
T10003	8570-8576	MD	denotes	should
T10004	8584-8589	DT	denotes	these
T10005	8590-8597	NNS	denotes	females
T10006	8598-8602	JJ	denotes	null
T10007	8603-8606	IN	denotes	for
T10008	8607-8611	NN	denotes	Atrx
T10009	8612-8614	IN	denotes	in
T10010	8615-8618	DT	denotes	the
T10011	8634-8641	NNS	denotes	tissues
T10012	8619-8633	JJ	denotes	extraembryonic
T10013	8641-8643	,	denotes	,
T10014	8643-8648	IN	denotes	since
T10015	8683-8690	VBZ	denotes	carries
T10016	8649-8652	DT	denotes	the
T10017	8672-8682	NN	denotes	chromosome
T10018	8653-8661	RB	denotes	normally
T10019	8662-8668	JJ	denotes	active
T10020	8669-8671	NN	denotes	Xm
T10021	8691-8694	DT	denotes	the
T10022	8708-8714	NN	denotes	allele
T10023	8695-8707	NN	denotes	Atrx Δ18Δneo
T10024	8714-8715	.	denotes	.
T10025	8715-8821	sentence	denotes	Although not phenotypically normal, some Atrx carrier females developed to term and went on to reproduce.
T10026	8716-8724	IN	denotes	Although
T10027	8744-8750	JJ	denotes	normal
T10028	8725-8728	RB	denotes	not
T10029	8729-8743	RB	denotes	phenotypically
T10030	8778-8787	VBD	denotes	developed
T10031	8750-8752	,	denotes	,
T10032	8752-8756	DT	denotes	some
T10033	8770-8777	NNS	denotes	females
T10034	8757-8761	NN	denotes	Atrx
T10035	8762-8769	NN	denotes	carrier
T10036	8788-8790	IN	denotes	to
T10037	8791-8795	NN	denotes	term
T10038	8796-8799	CC	denotes	and
T10039	8800-8804	VBD	denotes	went
T10040	8805-8807	RP	denotes	on
T10041	8808-8810	TO	denotes	to
T10042	8811-8820	VB	denotes	reproduce
T10043	8820-8821	.	denotes	.
T10044	8821-9139	sentence	denotes	Thus, the failure to correctly silence the paternally derived Atrx WT allele in the extraembryonic tissues of carrier females is consistent with our observations that in Atrxnull males, the Atrx protein plays an essential role in the development of the trophoblast and is necessary for survival in utero in the mouse.
T10045	8822-8826	RB	denotes	Thus
T10046	8948-8950	VBZ	denotes	is
T10047	8826-8828	,	denotes	,
T10048	8828-8831	DT	denotes	the
T10049	8832-8839	NN	denotes	failure
T10050	8840-8842	TO	denotes	to
T10051	8853-8860	VB	denotes	silence
T10052	8843-8852	RB	denotes	correctly
T10053	8861-8864	DT	denotes	the
T10054	8892-8898	NN	denotes	allele
T10146	9392-9401	NN	denotes	phosphate
T10055	8865-8875	RB	denotes	paternally
T10056	8876-8883	VBN	denotes	derived
T10057	8884-8891	NN	denotes	Atrx WT
T10058	8899-8901	IN	denotes	in
T10059	8902-8905	DT	denotes	the
T10060	8921-8928	NNS	denotes	tissues
T10061	8906-8920	JJ	denotes	extraembryonic
T10062	8929-8931	IN	denotes	of
T10063	8932-8939	NN	denotes	carrier
T10064	8940-8947	NNS	denotes	females
T10065	8951-8961	JJ	denotes	consistent
T10066	8962-8966	IN	denotes	with
T10067	8967-8970	PRP$	denotes	our
T10068	8971-8983	NNS	denotes	observations
T10069	8984-8988	IN	denotes	that
T10070	9025-9030	VBZ	denotes	plays
T10071	8989-8991	IN	denotes	in
T10072	8992-9000	JJ	denotes	Atrxnull
T10073	9001-9006	NNS	denotes	males
T10074	9006-9008	,	denotes	,
T10075	9008-9011	DT	denotes	the
T10076	9017-9024	NN	denotes	protein
T10077	9012-9016	NN	denotes	Atrx
T10078	9031-9033	DT	denotes	an
T10079	9044-9048	NN	denotes	role
T10080	9034-9043	JJ	denotes	essential
T10081	9049-9051	IN	denotes	in
T10082	9052-9055	DT	denotes	the
T10083	9056-9067	NN	denotes	development
T10084	9068-9070	IN	denotes	of
T10085	9071-9074	DT	denotes	the
T10086	9075-9086	NN	denotes	trophoblast
T10087	9087-9090	CC	denotes	and
T10088	9091-9093	VBZ	denotes	is
T10089	9094-9103	JJ	denotes	necessary
T10090	9104-9107	IN	denotes	for
T10091	9108-9116	NN	denotes	survival
T10092	9117-9119	FW	denotes	in
T10093	9120-9125	FW	denotes	utero
T10094	9126-9128	IN	denotes	in
T10095	9129-9132	DT	denotes	the
T10096	9133-9138	NN	denotes	mouse
T10097	9138-9139	.	denotes	.
T10098	9139-9324	sentence	denotes	The survival of Atrx carrier females contrasts with the phenotypes seen in carriers of mutations of other murine X-linked genes known to be essential in the extraembryonic compartment.
T10099	9140-9143	DT	denotes	The
T10100	9144-9152	NN	denotes	survival
T10101	9177-9186	VBZ	denotes	contrasts
T10102	9153-9155	IN	denotes	of
T10103	9156-9160	NN	denotes	Atrx
T10104	9169-9176	NNS	denotes	females
T10105	9161-9168	NN	denotes	carrier
T10106	9187-9191	IN	denotes	with
T10107	9192-9195	DT	denotes	the
T10108	9196-9206	NNS	denotes	phenotypes
T10109	9207-9211	VBN	denotes	seen
T10110	9212-9214	IN	denotes	in
T10111	9215-9223	NNS	denotes	carriers
T10112	9224-9226	IN	denotes	of
T10113	9227-9236	NNS	denotes	mutations
T10114	9237-9239	IN	denotes	of
T10115	9240-9245	JJ	denotes	other
T10116	9262-9267	NNS	denotes	genes
T10117	9246-9252	JJ	denotes	murine
T10118	9253-9254	NN	denotes	X
T10119	9255-9261	VBN	denotes	linked
T10120	9254-9255	HYPH	denotes	-
T10121	9268-9273	VBN	denotes	known
T10122	9274-9276	TO	denotes	to
T10123	9277-9279	VB	denotes	be
T10124	9280-9289	JJ	denotes	essential
T10125	9290-9292	IN	denotes	in
T10126	9293-9296	DT	denotes	the
T10127	9312-9323	NN	denotes	compartment
T10128	9297-9311	JJ	denotes	extraembryonic
T10129	9323-9324	.	denotes	.
T10130	9324-9563	sentence	denotes	For example, targeted disruption of the dyskerin (Dkc1), glucose 6-phosphate dehydrogenase (G6PD), and choroideremia (Chm) genes cause embryonic lethality in null male embryos through defects of the extraembryonic-derived tissues [29–31].
T10131	9325-9328	IN	denotes	For
T10132	9454-9459	VBP	denotes	cause
T10133	9329-9336	NN	denotes	example
T10134	9336-9338	,	denotes	,
T10135	9338-9346	VBN	denotes	targeted
T10136	9347-9357	NN	denotes	disruption
T10137	9358-9360	IN	denotes	of
T10138	9361-9364	DT	denotes	the
T10139	9448-9453	NNS	denotes	genes
T10140	9365-9373	NN	denotes	dyskerin
T10141	9374-9375	-LRB-	denotes	(
T10142	9375-9379	NN	denotes	Dkc1
T10143	9379-9380	-RRB-	denotes	)
T10144	9380-9382	,	denotes	,
T10145	9382-9389	NN	denotes	glucose
T10147	9390-9391	CD	denotes	6
T10148	9391-9392	HYPH	denotes	-
T10149	9402-9415	NN	denotes	dehydrogenase
T10150	9416-9417	-LRB-	denotes	(
T10151	9417-9421	NN	denotes	G6PD
T10152	9421-9422	-RRB-	denotes	)
T10153	9422-9424	,	denotes	,
T10154	9424-9427	CC	denotes	and
T10155	9428-9441	NN	denotes	choroideremia
T10156	9442-9443	-LRB-	denotes	(
T10157	9443-9446	NN	denotes	Chm
T10158	9446-9447	-RRB-	denotes	)
T10159	9460-9469	JJ	denotes	embryonic
T10160	9470-9479	NN	denotes	lethality
T10161	9480-9482	IN	denotes	in
T10162	9483-9487	JJ	denotes	null
T10163	9493-9500	NNS	denotes	embryos
T10164	9488-9492	JJ	denotes	male
T10165	9501-9508	IN	denotes	through
T10166	9509-9516	NNS	denotes	defects
T10167	9517-9519	IN	denotes	of
T10168	9520-9523	DT	denotes	the
T10169	9547-9554	NNS	denotes	tissues
T10170	9524-9538	JJ	denotes	extraembryonic
T10171	9539-9546	VBN	denotes	derived
T10172	9538-9539	HYPH	denotes	-
T10173	9555-9556	-LRB-	denotes	[
T10174	9556-9558	CD	denotes	29
T10175	9558-9559	SYM	denotes	–
T10176	9559-9561	CD	denotes	31
T10177	9561-9562	-RRB-	denotes	]
T10178	9562-9563	.	denotes	.
T10179	9563-9741	sentence	denotes	Female mice carrying mutations of these genes on the maternally inherited X chromosome also die in utero, whereas females that inherit the mutation on the Xp chromosome survive.
T10180	9564-9570	JJ	denotes	Female
T10181	9571-9575	NNS	denotes	mice
T10182	9656-9659	VBP	denotes	die
T10183	9576-9584	VBG	denotes	carrying
T10184	9585-9594	NNS	denotes	mutations
T10185	9595-9597	IN	denotes	of
T10186	9598-9603	DT	denotes	these
T10187	9604-9609	NNS	denotes	genes
T10188	9610-9612	IN	denotes	on
T10189	9613-9616	DT	denotes	the
T10190	9640-9650	NN	denotes	chromosome
T10191	9617-9627	RB	denotes	maternally
T10192	9628-9637	VBN	denotes	inherited
T10193	9638-9639	NN	denotes	X
T10194	9651-9655	RB	denotes	also
T10195	9660-9662	FW	denotes	in
T10196	9663-9668	FW	denotes	utero
T10197	9668-9670	,	denotes	,
T10198	9670-9677	IN	denotes	whereas
T10199	9733-9740	VBP	denotes	survive
T10200	9678-9685	NNS	denotes	females
T10201	9686-9690	WDT	denotes	that
T10202	9691-9698	VBP	denotes	inherit
T10203	9699-9702	DT	denotes	the
T10204	9703-9711	NN	denotes	mutation
T10205	9712-9714	IN	denotes	on
T10206	9715-9718	DT	denotes	the
T10207	9722-9732	NN	denotes	chromosome
T10208	9719-9721	NN	denotes	Xp
T10209	9740-9741	.	denotes	.
T10210	9741-9962	sentence	denotes	Thus, unlike Atrx, these genes and/or their effects on cell growth are unable to circumvent the processes that ultimately cause all cells in the extraembryonic tissues to express only the maternally derived X chromosome.
T10211	9742-9746	RB	denotes	Thus
T10212	9809-9812	VBP	denotes	are
T10213	9746-9748	,	denotes	,
T10214	9748-9754	IN	denotes	unlike
T10215	9755-9759	NN	denotes	Atrx
T10216	9759-9761	,	denotes	,
T10217	9761-9766	DT	denotes	these
T10218	9767-9772	NNS	denotes	genes
T10219	9773-9776	CC	denotes	and
T10220	9776-9777	HYPH	denotes	/
T10221	9777-9779	CC	denotes	or
T10222	9780-9785	PRP$	denotes	their
T10223	9786-9793	NNS	denotes	effects
T10224	9794-9796	IN	denotes	on
T10225	9797-9801	NN	denotes	cell
T10226	9802-9808	NN	denotes	growth
T10227	9813-9819	JJ	denotes	unable
T10228	9820-9822	TO	denotes	to
T10229	9823-9833	VB	denotes	circumvent
T10230	9834-9837	DT	denotes	the
T10231	9838-9847	NNS	denotes	processes
T10232	9848-9852	WDT	denotes	that
T10233	9864-9869	VBP	denotes	cause
T10234	9853-9863	RB	denotes	ultimately
T10235	9870-9873	DT	denotes	all
T10236	9874-9879	NNS	denotes	cells
T10237	9913-9920	VB	denotes	express
T10238	9880-9882	IN	denotes	in
T10239	9883-9886	DT	denotes	the
T10240	9902-9909	NNS	denotes	tissues
T10241	9887-9901	JJ	denotes	extraembryonic
T10242	9910-9912	TO	denotes	to
T10243	9921-9925	RB	denotes	only
T10244	9951-9961	NN	denotes	chromosome
T10245	9926-9929	DT	denotes	the
T10246	9930-9940	RB	denotes	maternally
T10247	9941-9948	VBN	denotes	derived
T10248	9949-9950	NN	denotes	X
T10249	9961-9962	.	denotes	.
T10250	9962-10087	sentence	denotes	How might expression of the paternal Atrx WT allele be maintained in the extraembryonic tissues of the Atrx carrier females?
T10251	9963-9966	WRB	denotes	How
T10252	10018-10028	VBN	denotes	maintained
T10253	9967-9972	MD	denotes	might
T10254	9973-9983	NN	denotes	expression
T10255	9984-9986	IN	denotes	of
T10256	9987-9990	DT	denotes	the
T10257	10008-10014	NN	denotes	allele
T10258	9991-9999	JJ	denotes	paternal
T10259	10000-10007	NN	denotes	Atrx WT
T10260	10015-10017	VB	denotes	be
T10261	10029-10031	IN	denotes	in
T10262	10032-10035	DT	denotes	the
T10263	10051-10058	NNS	denotes	tissues
T10264	10036-10050	JJ	denotes	extraembryonic
T10265	10059-10061	IN	denotes	of
T10266	10062-10065	DT	denotes	the
T10267	10079-10086	NNS	denotes	females
T10268	10066-10070	NN	denotes	Atrx
T10269	10071-10078	NN	denotes	carrier
T10270	10086-10087	.	denotes	?
T10271	10087-10321	sentence	denotes	One possibility is that, like some other X-linked genes, silencing of the Atrx gene on Xp is incomplete, such that there is always a low-level, leaky output of Atrx from a normally inactivated Xp chromosome in extraembryonic tissues.
T10272	10088-10091	CD	denotes	One
T10273	10092-10103	NN	denotes	possibility
T10274	10104-10106	VBZ	denotes	is
T10275	10107-10111	IN	denotes	that
T10276	10178-10180	VBZ	denotes	is
T10277	10111-10113	,	denotes	,
T10278	10113-10117	IN	denotes	like
T10279	10118-10122	DT	denotes	some
T10280	10138-10143	NNS	denotes	genes
T10281	10123-10128	JJ	denotes	other
T10282	10129-10130	NN	denotes	X
T10283	10131-10137	JJ	denotes	linked
T10284	10130-10131	HYPH	denotes	-
T10285	10143-10145	,	denotes	,
T10286	10145-10154	NN	denotes	silencing
T10287	10155-10157	IN	denotes	of
T10288	10158-10161	DT	denotes	the
T10289	10167-10171	NN	denotes	gene
T10290	10162-10166	NN	denotes	Atrx
T10291	10172-10174	IN	denotes	on
T10292	10175-10177	NN	denotes	Xp
T10293	10181-10191	JJ	denotes	incomplete
T10294	10191-10193	,	denotes	,
T10295	10193-10197	JJ	denotes	such
T10296	10209-10211	VBZ	denotes	is
T10297	10198-10202	IN	denotes	that
T10298	10203-10208	EX	denotes	there
T10299	10212-10218	RB	denotes	always
T10300	10219-10220	DT	denotes	a
T10301	10238-10244	NN	denotes	output
T10302	10221-10224	JJ	denotes	low
T10303	10225-10230	NN	denotes	level
T10304	10224-10225	HYPH	denotes	-
T10305	10230-10232	,	denotes	,
T10306	10232-10237	JJ	denotes	leaky
T10307	10245-10247	IN	denotes	of
T10308	10248-10252	NN	denotes	Atrx
T10309	10253-10257	IN	denotes	from
T10310	10258-10259	DT	denotes	a
T10311	10284-10294	NN	denotes	chromosome
T10312	10260-10268	RB	denotes	normally
T10313	10269-10280	VBN	denotes	inactivated
T10314	10281-10283	NN	denotes	Xp
T10315	10295-10297	IN	denotes	in
T10316	10298-10312	JJ	denotes	extraembryonic
T10317	10313-10320	NNS	denotes	tissues
T10318	10320-10321	.	denotes	.
T10319	10321-10599	sentence	denotes	However, it was recently demonstrated that the paternal Atrx (called Xnp) allele is completely silenced in a normal mouse trophoblast stem cell line [32], suggesting that Atrx does not normally escape imprinted X-inactivation in the extraembryonic tissues of wild-type females.
T10320	10322-10329	RB	denotes	However
T10321	10347-10359	VBN	denotes	demonstrated
T10322	10329-10331	,	denotes	,
T10323	10331-10333	PRP	denotes	it
T10324	10334-10337	VBD	denotes	was
T10325	10338-10346	RB	denotes	recently
T10326	10360-10364	IN	denotes	that
T10327	10417-10425	VBN	denotes	silenced
T10328	10365-10368	DT	denotes	the
T10329	10396-10402	NN	denotes	allele
T10330	10369-10377	JJ	denotes	paternal
T10331	10378-10382	NN	denotes	Atrx
T10332	10383-10384	-LRB-	denotes	(
T10333	10384-10390	VBN	denotes	called
T10334	10391-10394	NN	denotes	Xnp
T10335	10394-10395	-RRB-	denotes	)
T10336	10403-10405	VBZ	denotes	is
T10337	10406-10416	RB	denotes	completely
T10338	10426-10428	IN	denotes	in
T10339	10429-10430	DT	denotes	a
T10340	10466-10470	NN	denotes	line
T10341	10431-10437	JJ	denotes	normal
T10342	10438-10443	NN	denotes	mouse
T10343	10444-10455	NN	denotes	trophoblast
T10344	10456-10460	NN	denotes	stem
T10345	10461-10465	NN	denotes	cell
T10346	10471-10472	-LRB-	denotes	[
T10347	10472-10474	CD	denotes	32
T10348	10474-10475	-RRB-	denotes	]
T10349	10475-10477	,	denotes	,
T10350	10477-10487	VBG	denotes	suggesting
T10351	10488-10492	IN	denotes	that
T10352	10516-10522	VB	denotes	escape
T10353	10493-10497	NN	denotes	Atrx
T10354	10498-10502	VBZ	denotes	does
T10355	10503-10506	RB	denotes	not
T10356	10507-10515	RB	denotes	normally
T10357	10523-10532	VBN	denotes	imprinted
T10358	10535-10547	NN	denotes	inactivation
T10359	10533-10534	NN	denotes	X
T10360	10534-10535	HYPH	denotes	-
T10361	10548-10550	IN	denotes	in
T10362	10551-10554	DT	denotes	the
T10363	10570-10577	NNS	denotes	tissues
T10364	10555-10569	JJ	denotes	extraembryonic
T10365	10578-10580	IN	denotes	of
T10366	10581-10585	JJ	denotes	wild
T10367	10586-10590	NN	denotes	type
T10368	10585-10586	HYPH	denotes	-
T10369	10591-10598	NNS	denotes	females
T10370	10598-10599	.	denotes	.
T10371	10599-10723	sentence	denotes	Thus, the expression of the Xp-linked Atrx WT allele that we observed is unique to female carriers of the Atrx null allele.
T10372	10600-10604	RB	denotes	Thus
T10373	10670-10672	VBZ	denotes	is
T10374	10604-10606	,	denotes	,
T10375	10606-10609	DT	denotes	the
T10376	10610-10620	NN	denotes	expression
T10377	10621-10623	IN	denotes	of
T10378	10624-10627	DT	denotes	the
T10379	10646-10652	NN	denotes	allele
T10380	10628-10630	NN	denotes	Xp
T10381	10631-10637	VBN	denotes	linked
T10382	10630-10631	HYPH	denotes	-
T10383	10638-10645	NN	denotes	Atrx WT
T10384	10653-10657	WDT	denotes	that
T10385	10661-10669	VBD	denotes	observed
T10386	10658-10660	PRP	denotes	we
T10387	10673-10679	JJ	denotes	unique
T10388	10680-10682	IN	denotes	to
T10389	10683-10689	JJ	denotes	female
T10390	10690-10698	NNS	denotes	carriers
T10391	10699-10701	IN	denotes	of
T10392	10702-10705	DT	denotes	the
T10393	10716-10722	NN	denotes	allele
T10394	10706-10715	JJ	denotes	Atrx null
T10395	10722-10723	.	denotes	.
T10396	10723-11044	sentence	denotes	Perhaps a more likely explanation for this phenomenon stems from experimental observations suggesting that imprinted X-inactivation is not imposed on all precursors of the mouse extraembryonic tissues: A subpopulation of cells may escape this process and make a random “choice” of which X chromosome will be inactivated.
T10397	10724-10731	RB	denotes	Perhaps
T10398	10778-10783	VBZ	denotes	stems
T10399	10732-10733	DT	denotes	a
T10400	10746-10757	NN	denotes	explanation
T10401	10734-10738	RBR	denotes	more
T10402	10739-10745	JJ	denotes	likely
T10403	10758-10761	IN	denotes	for
T10404	10762-10766	DT	denotes	this
T10405	10767-10777	NN	denotes	phenomenon
T10406	10784-10788	IN	denotes	from
T10407	10789-10801	JJ	denotes	experimental
T10408	10802-10814	NNS	denotes	observations
T10409	10815-10825	VBG	denotes	suggesting
T10410	10826-10830	IN	denotes	that
T10411	10955-10961	VB	denotes	escape
T10412	10831-10840	VBN	denotes	imprinted
T10413	10843-10855	NN	denotes	inactivation
T10414	10841-10842	NN	denotes	X
T10415	10842-10843	HYPH	denotes	-
T10416	10863-10870	VBN	denotes	imposed
T10417	10856-10858	VBZ	denotes	is
T10418	10859-10862	RB	denotes	not
T10419	10871-10873	IN	denotes	on
T10420	10874-10877	DT	denotes	all
T10421	10878-10888	NNS	denotes	precursors
T10422	10889-10891	IN	denotes	of
T10423	10892-10895	DT	denotes	the
T10424	10917-10924	NNS	denotes	tissues
T10425	10896-10901	NN	denotes	mouse
T10426	10902-10916	JJ	denotes	extraembryonic
T10427	10924-10926	:	denotes	:
T10428	10926-10927	DT	denotes	A
T10429	10928-10941	NN	denotes	subpopulation
T10430	10942-10944	IN	denotes	of
T10431	10945-10950	NNS	denotes	cells
T10432	10951-10954	MD	denotes	may
T10433	10962-10966	DT	denotes	this
T10434	10967-10974	NN	denotes	process
T10435	10975-10978	CC	denotes	and
T10436	10979-10983	VB	denotes	make
T10437	10984-10985	DT	denotes	a
T10438	10994-11000	NN	denotes	choice
T10439	10986-10992	JJ	denotes	random
T10440	10993-10994	``	denotes	“
T10441	11000-11001	''	denotes	”
T10442	11002-11004	IN	denotes	of
T10443	11005-11010	WDT	denotes	which
T10444	11013-11023	NN	denotes	chromosome
T10445	11011-11012	NN	denotes	X
T10446	11032-11043	VBN	denotes	inactivated
T10447	11024-11028	MD	denotes	will
T10448	11029-11031	VB	denotes	be
T10449	11043-11044	.	denotes	.
T10450	11044-11172	sentence	denotes	On average, 50% of the cells in this randomly inactivating subpopulation would be expected to maintain an active Xp chromosome.
T10451	11045-11047	IN	denotes	On
T10452	11127-11135	VBN	denotes	expected
T10453	11048-11055	JJ	denotes	average
T10454	11055-11057	,	denotes	,
T10455	11057-11059	CD	denotes	50
T10456	11059-11060	NN	denotes	%
T10457	11061-11063	IN	denotes	of
T10458	11064-11067	DT	denotes	the
T10459	11068-11073	NNS	denotes	cells
T10460	11074-11076	IN	denotes	in
T10461	11077-11081	DT	denotes	this
T10462	11104-11117	NN	denotes	subpopulation
T10463	11082-11090	RB	denotes	randomly
T10464	11091-11103	VBG	denotes	inactivating
T10465	11118-11123	MD	denotes	would
T10466	11124-11126	VB	denotes	be
T10467	11136-11138	TO	denotes	to
T10468	11139-11147	VB	denotes	maintain
T10469	11148-11150	DT	denotes	an
T10470	11161-11171	NN	denotes	chromosome
T10471	11151-11157	JJ	denotes	active
T10472	11158-11160	NN	denotes	Xp
T10473	11171-11172	.	denotes	.
T10474	11172-11388	sentence	denotes	In support of this hypothesis, it has been demonstrated that expression of paternally transmitted X-linked lacZ [33,34] and GFP [35] transgenes failed to be silenced in a small subpopulation of extraembryonic cells.
T10475	11173-11175	IN	denotes	In
T10476	11216-11228	VBN	denotes	demonstrated
T10477	11176-11183	NN	denotes	support
T10478	11184-11186	IN	denotes	of
T10479	11187-11191	DT	denotes	this
T10480	11192-11202	NN	denotes	hypothesis
T10481	11202-11204	,	denotes	,
T10482	11204-11206	PRP	denotes	it
T10483	11207-11210	VBZ	denotes	has
T10484	11211-11215	VBN	denotes	been
T10485	11229-11233	IN	denotes	that
T10486	11317-11323	VBD	denotes	failed
T10487	11234-11244	NN	denotes	expression
T10488	11245-11247	IN	denotes	of
T10489	11248-11258	RB	denotes	paternally
T10490	11259-11270	VBN	denotes	transmitted
T10491	11280-11284	NN	denotes	lacZ
T10492	11271-11272	NN	denotes	X
T10493	11273-11279	VBN	denotes	linked
T10494	11272-11273	HYPH	denotes	-
T10495	11306-11316	NNS	denotes	transgenes
T10496	11285-11286	-LRB-	denotes	[
T10497	11289-11291	CD	denotes	34
T10498	11286-11288	CD	denotes	33
T10499	11288-11289	,	denotes	,
T10500	11291-11292	-RRB-	denotes	]
T10501	11293-11296	CC	denotes	and
T10502	11297-11300	NN	denotes	GFP
T10503	11301-11302	-LRB-	denotes	[
T10504	11302-11304	CD	denotes	35
T10505	11304-11305	-RRB-	denotes	]
T10506	11324-11326	TO	denotes	to
T10507	11330-11338	VBN	denotes	silenced
T10508	11327-11329	VB	denotes	be
T10509	11339-11341	IN	denotes	in
T10510	11342-11343	DT	denotes	a
T10511	11350-11363	NN	denotes	subpopulation
T10512	11344-11349	JJ	denotes	small
T10513	11364-11366	IN	denotes	of
T10514	11367-11381	JJ	denotes	extraembryonic
T10515	11382-11387	NNS	denotes	cells
T10516	11387-11388	.	denotes	.
T10517	11388-11582	sentence	denotes	Further, it has been shown that in a subpopulation of extraembryonic cells, it is the Xm rather than the Xp that undergoes late replication, a molecular correlate of the inactive state [18,36].
T10518	11389-11396	RB	denotes	Further
T10519	11410-11415	VBN	denotes	shown
T10520	11396-11398	,	denotes	,
T10521	11398-11400	PRP	denotes	it
T10522	11401-11404	VBZ	denotes	has
T10523	11405-11409	VBN	denotes	been
T10524	11416-11420	IN	denotes	that
T10525	11468-11470	VBZ	denotes	is
T10526	11421-11423	IN	denotes	in
T10527	11424-11425	DT	denotes	a
T10528	11426-11439	NN	denotes	subpopulation
T10529	11440-11442	IN	denotes	of
T10530	11443-11457	JJ	denotes	extraembryonic
T10531	11458-11463	NNS	denotes	cells
T10532	11463-11465	,	denotes	,
T10533	11465-11467	PRP	denotes	it
T10534	11471-11474	DT	denotes	the
T10535	11475-11477	NN	denotes	Xm
T10536	11478-11484	JJ	denotes	rather
T10537	11485-11489	IN	denotes	than
T10538	11490-11493	DT	denotes	the
T10539	11494-11496	NN	denotes	Xp
T10540	11497-11501	WDT	denotes	that
T10541	11502-11511	VBZ	denotes	undergoes
T10542	11512-11516	JJ	denotes	late
T10543	11517-11528	NN	denotes	replication
T10544	11528-11530	,	denotes	,
T10545	11530-11531	DT	denotes	a
T10546	11542-11551	NN	denotes	correlate
T10547	11532-11541	JJ	denotes	molecular
T10548	11552-11554	IN	denotes	of
T10549	11555-11558	DT	denotes	the
T10550	11568-11573	NN	denotes	state
T10551	11559-11567	JJ	denotes	inactive
T10552	11574-11575	-LRB-	denotes	[
T10553	11578-11580	CD	denotes	36
T10554	11575-11577	CD	denotes	18
T10555	11577-11578	,	denotes	,
T10556	11580-11581	-RRB-	denotes	]
T10557	11581-11582	.	denotes	.
T10558	11582-11870	sentence	denotes	Although initially small and quickly diluted in normal embryos, the cellular subpopulation that inactivates the Xm chromosome could rapidly expand to replace the normally imprinted cells in extraembryonic lineages if the normal silencing of Xp compromises cell growth or differentiation.
T10559	11583-11591	IN	denotes	Although
T10560	11602-11607	JJ	denotes	small
T10561	11592-11601	RB	denotes	initially
T10562	11723-11729	VB	denotes	expand
T10563	11608-11611	CC	denotes	and
T10564	11612-11619	RB	denotes	quickly
T10565	11620-11627	VBN	denotes	diluted
T10566	11628-11630	IN	denotes	in
T10567	11631-11637	JJ	denotes	normal
T10568	11638-11645	NNS	denotes	embryos
T10569	11645-11647	,	denotes	,
T10570	11647-11650	DT	denotes	the
T10571	11660-11673	NN	denotes	subpopulation
T10572	11651-11659	JJ	denotes	cellular
T10573	11674-11678	WDT	denotes	that
T10574	11679-11690	VBZ	denotes	inactivates
T10575	11691-11694	DT	denotes	the
T10576	11698-11708	NN	denotes	chromosome
T10577	11695-11697	NN	denotes	Xm
T10578	11709-11714	MD	denotes	could
T10579	11715-11722	RB	denotes	rapidly
T10580	11730-11732	TO	denotes	to
T10581	11733-11740	VB	denotes	replace
T10582	11741-11744	DT	denotes	the
T10583	11764-11769	NNS	denotes	cells
T10584	11745-11753	RB	denotes	normally
T10585	11754-11763	VBN	denotes	imprinted
T10586	11770-11772	IN	denotes	in
T10587	11773-11787	JJ	denotes	extraembryonic
T10588	11788-11796	NNS	denotes	lineages
T10589	11797-11799	IN	denotes	if
T10590	11827-11838	VBZ	denotes	compromises
T10591	11800-11803	DT	denotes	the
T10592	11811-11820	NN	denotes	silencing
T10593	11804-11810	JJ	denotes	normal
T10594	11821-11823	IN	denotes	of
T10595	11824-11826	NN	denotes	Xp
T10596	11839-11843	NN	denotes	cell
T10597	11844-11850	NN	denotes	growth
T10598	11851-11853	CC	denotes	or
T10599	11854-11869	NN	denotes	differentiation
T10600	11869-11870	.	denotes	.
T10601	11870-12224	sentence	denotes	Interestingly, it has been suggested that the size of the population that initially escapes imprinting may range widely (from 0% to 30%), even between genetically identical embryos [37], and this may account for the variable phenotype observed among females bearing Xm-linked mutant alleles of genes essential for normal extraembryonic development [38].
T10602	11871-11884	RB	denotes	Interestingly
T10603	11898-11907	VBN	denotes	suggested
T10604	11884-11886	,	denotes	,
T10605	11886-11888	PRP	denotes	it
T10606	11889-11892	VBZ	denotes	has
T10607	11893-11897	VBN	denotes	been
T10608	11908-11912	IN	denotes	that
T10609	11978-11983	VB	denotes	range
T10610	11913-11916	DT	denotes	the
T10611	11917-11921	NN	denotes	size
T10612	11922-11924	IN	denotes	of
T10613	11925-11928	DT	denotes	the
T10614	11929-11939	NN	denotes	population
T10615	11940-11944	WDT	denotes	that
T10616	11955-11962	VBZ	denotes	escapes
T10617	11945-11954	RB	denotes	initially
T10618	11963-11973	NN	denotes	imprinting
T10619	11974-11977	MD	denotes	may
T10620	11984-11990	RB	denotes	widely
T10621	11991-11992	-LRB-	denotes	(
T10622	11992-11996	IN	denotes	from
T10623	11997-11998	CD	denotes	0
T10624	11998-11999	NN	denotes	%
T10625	12000-12002	IN	denotes	to
T10626	12003-12005	CD	denotes	30
T10627	12005-12006	NN	denotes	%
T10628	12006-12007	-RRB-	denotes	)
T10629	12007-12009	,	denotes	,
T10630	12009-12013	RB	denotes	even
T10631	12014-12021	IN	denotes	between
T10632	12022-12033	RB	denotes	genetically
T10633	12034-12043	JJ	denotes	identical
T10634	12044-12051	NNS	denotes	embryos
T10635	12052-12053	-LRB-	denotes	[
T10636	12053-12055	CD	denotes	37
T10637	12055-12056	-RRB-	denotes	]
T10638	12056-12058	,	denotes	,
T10639	12058-12061	CC	denotes	and
T10640	12062-12066	DT	denotes	this
T10641	12071-12078	VB	denotes	account
T10642	12067-12070	MD	denotes	may
T10643	12079-12082	IN	denotes	for
T10644	12083-12086	DT	denotes	the
T10645	12096-12105	NN	denotes	phenotype
T10646	12087-12095	JJ	denotes	variable
T10647	12106-12114	VBN	denotes	observed
T10648	12115-12120	IN	denotes	among
T10649	12121-12128	NNS	denotes	females
T10650	12129-12136	VBG	denotes	bearing
T10651	12137-12139	NN	denotes	Xm
T10652	12140-12146	VBN	denotes	linked
T10653	12139-12140	HYPH	denotes	-
T10654	12154-12161	NNS	denotes	alleles
T10655	12147-12153	NN	denotes	mutant
T10656	12162-12164	IN	denotes	of
T10657	12165-12170	NNS	denotes	genes
T10658	12171-12180	JJ	denotes	essential
T10659	12181-12184	IN	denotes	for
T10660	12185-12191	JJ	denotes	normal
T10661	12207-12218	NN	denotes	development
T10662	12192-12206	JJ	denotes	extraembryonic
T10663	12219-12220	-LRB-	denotes	[
T10664	12220-12222	CD	denotes	38
T10665	12222-12223	-RRB-	denotes	]
T10666	12223-12224	.	denotes	.
T10667	12224-12377	sentence	denotes	Put simply, carrier females bearing a small initial population of escaping cells would be more severely affected than those bearing a larger population.
T10668	12225-12228	VBN	denotes	Put
T10669	12312-12314	VB	denotes	be
T10670	12229-12235	RB	denotes	simply
T10671	12235-12237	,	denotes	,
T10672	12237-12244	NN	denotes	carrier
T10673	12245-12252	NNS	denotes	females
T10674	12253-12260	VBG	denotes	bearing
T10675	12261-12262	DT	denotes	a
T10676	12277-12287	NN	denotes	population
T10677	12263-12268	JJ	denotes	small
T10678	12269-12276	JJ	denotes	initial
T10679	12288-12290	IN	denotes	of
T10680	12291-12299	VBG	denotes	escaping
T10681	12300-12305	NNS	denotes	cells
T10682	12306-12311	MD	denotes	would
T10683	12315-12319	RBR	denotes	more
T10684	12320-12328	RB	denotes	severely
T10685	12329-12337	VBN	denotes	affected
T10686	12338-12342	IN	denotes	than
T10687	12343-12348	DT	denotes	those
T10688	12349-12356	VBG	denotes	bearing
T10689	12357-12358	DT	denotes	a
T10690	12366-12376	NN	denotes	population
T10691	12359-12365	JJR	denotes	larger
T10692	12376-12377	.	denotes	.
T10693	12377-12564	sentence	denotes	This could explain why we have observed significant phenotypic variation among Atrx carrier females, with some carriers dying in utero by 9.5 dpc (Table 1) and others developing to term.
T10694	12378-12382	DT	denotes	This
T10695	12389-12396	VB	denotes	explain
T10696	12383-12388	MD	denotes	could
T10697	12397-12400	WRB	denotes	why
T10698	12409-12417	VBN	denotes	observed
T10699	12401-12403	PRP	denotes	we
T10700	12404-12408	VBP	denotes	have
T10701	12418-12429	JJ	denotes	significant
T10702	12441-12450	NN	denotes	variation
T10703	12430-12440	JJ	denotes	phenotypic
T10704	12451-12456	IN	denotes	among
T10705	12457-12461	NN	denotes	Atrx
T10706	12462-12469	NN	denotes	carrier
T10707	12470-12477	NNS	denotes	females
T10708	12477-12479	,	denotes	,
T10709	12479-12483	IN	denotes	with
T10710	12484-12488	DT	denotes	some
T10711	12489-12497	NNS	denotes	carriers
T10712	12498-12503	VBG	denotes	dying
T10713	12504-12506	FW	denotes	in
T10714	12507-12512	FW	denotes	utero
T10715	12513-12515	IN	denotes	by
T10716	12516-12519	CD	denotes	9.5
T10717	12520-12523	NNS	denotes	dpc
T10718	12524-12525	-LRB-	denotes	(
T10719	12525-12530	NN	denotes	Table
T10720	12531-12532	CD	denotes	1
T10721	12532-12533	-RRB-	denotes	)
T10722	12534-12537	CC	denotes	and
T10723	12538-12544	NNS	denotes	others
T10724	12545-12555	VBG	denotes	developing
T10725	12556-12558	IN	denotes	to
T10726	12559-12563	NN	denotes	term
T10727	12563-12564	.	denotes	.
T10728	12564-12733	sentence	denotes	Another possible mechanism is that inactivation of the paternal X proceeds normally in all cells, but subsequently the Atrx gene within individual cells is reactivated.
T10729	12565-12572	DT	denotes	Another
T10730	12582-12591	NN	denotes	mechanism
T10731	12573-12581	JJ	denotes	possible
T10732	12592-12594	VBZ	denotes	is
T10733	12595-12599	IN	denotes	that
T10734	12631-12639	VBZ	denotes	proceeds
T10735	12600-12612	NN	denotes	inactivation
T10736	12613-12615	IN	denotes	of
T10737	12616-12619	DT	denotes	the
T10738	12629-12630	NN	denotes	X
T10739	12620-12628	JJ	denotes	paternal
T10740	12640-12648	RB	denotes	normally
T10741	12649-12651	IN	denotes	in
T10742	12652-12655	DT	denotes	all
T10743	12656-12661	NNS	denotes	cells
T10744	12661-12663	,	denotes	,
T10745	12663-12666	CC	denotes	but
T10746	12667-12679	RB	denotes	subsequently
T10747	12721-12732	VBN	denotes	reactivated
T10748	12680-12683	DT	denotes	the
T10749	12689-12693	NN	denotes	gene
T10750	12684-12688	NN	denotes	Atrx
T10751	12694-12700	IN	denotes	within
T10752	12701-12711	JJ	denotes	individual
T10753	12712-12717	NNS	denotes	cells
T10754	12718-12720	VBZ	denotes	is
T10755	12732-12733	.	denotes	.
T10756	12733-12846	sentence	denotes	Alternatively, in the absence of Atrx, the paternal allele may partially escape the normal process of silencing.
T10757	12734-12747	RB	denotes	Alternatively
T10758	12807-12813	VB	denotes	escape
T10759	12747-12749	,	denotes	,
T10760	12749-12751	IN	denotes	in
T10761	12752-12755	DT	denotes	the
T10762	12756-12763	NN	denotes	absence
T10763	12764-12766	IN	denotes	of
T10764	12767-12771	NN	denotes	Atrx
T10765	12771-12773	,	denotes	,
T10766	12773-12776	DT	denotes	the
T10767	12786-12792	NN	denotes	allele
T10768	12777-12785	JJ	denotes	paternal
T10769	12793-12796	MD	denotes	may
T10770	12797-12806	RB	denotes	partially
T10771	12814-12817	DT	denotes	the
T10772	12825-12832	NN	denotes	process
T10773	12818-12824	JJ	denotes	normal
T10774	12833-12835	IN	denotes	of
T10775	12836-12845	NN	denotes	silencing
T10776	12845-12846	.	denotes	.
T10777	12846-13100	sentence	denotes	In both of these cases, other genes on the paternal X chromosome must be inactivated and remain so, since blocking inactivation of the entire Xp chromosome causes embryonic lethality due to biallelic expression of X-linked genes in the trophoblast [39].
T10778	12847-12849	IN	denotes	In
T10779	12920-12931	VBN	denotes	inactivated
T10780	12850-12854	DT	denotes	both
T10781	12855-12857	IN	denotes	of
T10782	12858-12863	DT	denotes	these
T10783	12864-12869	NNS	denotes	cases
T10784	12869-12871	,	denotes	,
T10785	12871-12876	JJ	denotes	other
T10786	12877-12882	NNS	denotes	genes
T10787	12883-12885	IN	denotes	on
T10788	12886-12889	DT	denotes	the
T10789	12901-12911	NN	denotes	chromosome
T10790	12890-12898	JJ	denotes	paternal
T10791	12899-12900	NN	denotes	X
T10792	12912-12916	MD	denotes	must
T10793	12917-12919	VB	denotes	be
T10794	12932-12935	CC	denotes	and
T10795	12936-12942	VBP	denotes	remain
T10796	12943-12945	RB	denotes	so
T10797	12945-12947	,	denotes	,
T10798	12947-12952	IN	denotes	since
T10799	13003-13009	VBZ	denotes	causes
T10800	12953-12961	VBG	denotes	blocking
T10801	12962-12974	NN	denotes	inactivation
T10802	12975-12977	IN	denotes	of
T10803	12978-12981	DT	denotes	the
T10804	12992-13002	NN	denotes	chromosome
T10805	12982-12988	JJ	denotes	entire
T10806	12989-12991	NN	denotes	Xp
T10807	13010-13019	JJ	denotes	embryonic
T10808	13020-13029	NN	denotes	lethality
T10809	13030-13033	IN	denotes	due
T10810	13034-13036	IN	denotes	to
T10811	13037-13046	JJ	denotes	biallelic
T10812	13047-13057	NN	denotes	expression
T10813	13058-13060	IN	denotes	of
T10814	13061-13062	NN	denotes	X
T10815	13063-13069	VBN	denotes	linked
T10816	13062-13063	HYPH	denotes	-
T10817	13070-13075	NNS	denotes	genes
T10818	13076-13078	IN	denotes	in
T10819	13079-13082	DT	denotes	the
T10820	13083-13094	NN	denotes	trophoblast
T10821	13095-13096	-LRB-	denotes	[
T10822	13096-13098	CD	denotes	39
T10823	13098-13099	-RRB-	denotes	]
T10824	13099-13100	.	denotes	.
T10925	13102-13109	NN	denotes	Summary
T10926	13109-13226	sentence	denotes	ATR-X syndrome is the first human genetic disease known to be caused by mutations in a chromatin remodelling factor.
T10927	13110-13113	NN	denotes	ATR
T10928	13114-13115	NN	denotes	X
T10929	13113-13114	HYPH	denotes	-
T10930	13116-13124	NN	denotes	syndrome
T10931	13125-13127	VBZ	denotes	is
T10932	13128-13131	DT	denotes	the
T10933	13152-13159	NN	denotes	disease
T10934	13132-13137	JJ	denotes	first
T10935	13138-13143	JJ	denotes	human
T10936	13144-13151	JJ	denotes	genetic
T10937	13160-13165	VBN	denotes	known
T10938	13166-13168	TO	denotes	to
T10939	13172-13178	VBN	denotes	caused
T10940	13169-13171	VB	denotes	be
T10941	13179-13181	IN	denotes	by
T10942	13182-13191	NNS	denotes	mutations
T10943	13192-13194	IN	denotes	in
T10944	13195-13196	DT	denotes	a
T10945	13219-13225	NN	denotes	factor
T10946	13197-13206	NN	denotes	chromatin
T10947	13207-13218	NN	denotes	remodelling
T10948	13225-13226	.	denotes	.
T10949	13226-13329	sentence	denotes	At present we do not know how ATRX influences gene expression or what effect it has on cell behaviour.
T10950	13227-13229	IN	denotes	At
T10951	13248-13252	VB	denotes	know
T10952	13230-13237	JJ	denotes	present
T10953	13238-13240	PRP	denotes	we
T10954	13241-13243	VBP	denotes	do
T10955	13244-13247	RB	denotes	not
T10956	13253-13256	WRB	denotes	how
T10957	13262-13272	VBZ	denotes	influences
T10958	13257-13261	NN	denotes	ATRX
T10959	13273-13277	NN	denotes	gene
T10960	13278-13288	NN	denotes	expression
T10961	13289-13291	CC	denotes	or
T10962	13292-13296	WDT	denotes	what
T10963	13297-13303	NN	denotes	effect
T10964	13307-13310	VBZ	denotes	has
T10965	13304-13306	PRP	denotes	it
T10966	13311-13313	IN	denotes	on
T10967	13314-13318	NN	denotes	cell
T10968	13319-13328	NN	denotes	behaviour
T10969	13328-13329	.	denotes	.
T10970	13329-13505	sentence	denotes	Nevertheless, we have previously noted that none of the natural mutations causing ATR-X syndrome are nulls, which suggests that it plays a critical role in normal development.
T10971	13330-13342	RB	denotes	Nevertheless
T10972	13363-13368	VBN	denotes	noted
T10973	13342-13344	,	denotes	,
T10974	13344-13346	PRP	denotes	we
T10975	13347-13351	VBP	denotes	have
T10976	13352-13362	RB	denotes	previously
T10977	13369-13373	IN	denotes	that
T10978	13427-13430	VBP	denotes	are
T10979	13374-13378	NN	denotes	none
T10980	13379-13381	IN	denotes	of
T10981	13382-13385	DT	denotes	the
T10982	13394-13403	NNS	denotes	mutations
T10983	13386-13393	JJ	denotes	natural
T10984	13404-13411	VBG	denotes	causing
T10985	13412-13415	NN	denotes	ATR
T10986	13416-13417	NN	denotes	X
T10987	13415-13416	HYPH	denotes	-
T10988	13418-13426	NN	denotes	syndrome
T10989	13431-13436	NNS	denotes	nulls
T10990	13436-13438	,	denotes	,
T10991	13438-13443	WDT	denotes	which
T10992	13444-13452	VBZ	denotes	suggests
T10993	13453-13457	IN	denotes	that
T10994	13461-13466	VBZ	denotes	plays
T10995	13458-13460	PRP	denotes	it
T10996	13467-13468	DT	denotes	a
T10997	13478-13482	NN	denotes	role
T10998	13469-13477	JJ	denotes	critical
T10999	13483-13485	IN	denotes	in
T11000	13486-13492	JJ	denotes	normal
T11001	13493-13504	NN	denotes	development
T11002	13504-13505	.	denotes	.
T11003	13505-13707	sentence	denotes	Results of conditional inactivation of Atrx in the developing mouse forebrain, based on the Atrx flox allele described here, shows that Atrx exerts a major effect on terminally differentiating neurons.
T11004	13506-13513	NNS	denotes	Results
T11005	13631-13636	VBZ	denotes	shows
T11006	13514-13516	IN	denotes	of
T11007	13517-13528	JJ	denotes	conditional
T11008	13529-13541	NN	denotes	inactivation
T11009	13542-13544	IN	denotes	of
T11010	13545-13549	NN	denotes	Atrx
T11011	13550-13552	IN	denotes	in
T11012	13553-13556	DT	denotes	the
T11013	13574-13583	NN	denotes	forebrain
T11014	13557-13567	VBG	denotes	developing
T11015	13568-13573	NN	denotes	mouse
T11016	13583-13585	,	denotes	,
T11017	13585-13590	VBN	denotes	based
T11018	13591-13593	IN	denotes	on
T11019	13594-13597	DT	denotes	the
T11020	13608-13614	NN	denotes	allele
T11021	13598-13607	NN	denotes	Atrx flox
T11022	13615-13624	VBN	denotes	described
T11023	13625-13629	RB	denotes	here
T11024	13629-13631	,	denotes	,
T11025	13637-13641	IN	denotes	that
T11026	13647-13653	VBZ	denotes	exerts
T11027	13642-13646	NN	denotes	Atrx
T11028	13654-13655	DT	denotes	a
T11029	13662-13668	NN	denotes	effect
T11030	13656-13661	JJ	denotes	major
T11031	13669-13671	IN	denotes	on
T11032	13672-13682	RB	denotes	terminally
T11033	13683-13698	VBG	denotes	differentiating
T11034	13699-13706	NNS	denotes	neurons
T11035	13706-13707	.	denotes	.
T11036	13707-13770	sentence	denotes	Conditional inactivation of Atrx in other tissues is underway.
T11037	13708-13719	JJ	denotes	Conditional
T11038	13720-13732	NN	denotes	inactivation
T11039	13758-13760	VBZ	denotes	is
T11040	13733-13735	IN	denotes	of
T11041	13736-13740	NN	denotes	Atrx
T11042	13741-13743	IN	denotes	in
T11043	13744-13749	JJ	denotes	other
T11044	13750-13757	NNS	denotes	tissues
T11045	13761-13769	JJ	denotes	underway
T11046	13769-13770	.	denotes	.
T11047	13770-13959	sentence	denotes	Here we have shown that animal-wide disruption of the Atrx gene causes a severe embryonic-lethal phenotype, revealing an essential role for Atrx in the formation of the murine trophoblast.
T11048	13771-13775	RB	denotes	Here
T11049	13784-13789	VBN	denotes	shown
T11050	13776-13778	PRP	denotes	we
T11051	13779-13783	VBP	denotes	have
T11052	13790-13794	IN	denotes	that
T11053	13835-13841	VBZ	denotes	causes
T11054	13795-13801	NN	denotes	animal
T11055	13802-13806	JJ	denotes	wide
T11056	13801-13802	HYPH	denotes	-
T11057	13807-13817	NN	denotes	disruption
T11058	13818-13820	IN	denotes	of
T11059	13821-13824	DT	denotes	the
T11060	13830-13834	NN	denotes	gene
T11061	13825-13829	NN	denotes	Atrx
T11062	13842-13843	DT	denotes	a
T11063	13868-13877	NN	denotes	phenotype
T11064	13844-13850	JJ	denotes	severe
T11065	13851-13860	JJ	denotes	embryonic
T11066	13861-13867	JJ	denotes	lethal
T11067	13860-13861	HYPH	denotes	-
T11068	13877-13879	,	denotes	,
T11069	13879-13888	VBG	denotes	revealing
T11070	13889-13891	DT	denotes	an
T11071	13902-13906	NN	denotes	role
T11072	13892-13901	JJ	denotes	essential
T11073	13907-13910	IN	denotes	for
T11074	13911-13915	NN	denotes	Atrx
T11075	13916-13918	IN	denotes	in
T11076	13919-13922	DT	denotes	the
T11077	13923-13932	NN	denotes	formation
T11078	13933-13935	IN	denotes	of
T11079	13936-13939	DT	denotes	the
T11080	13947-13958	NN	denotes	trophoblast
T11081	13940-13946	JJ	denotes	murine
T11082	13958-13959	.	denotes	.
T11083	13959-14090	sentence	denotes	In addition, Atrx appears to escape imprinted X-chromosome inactivation in the extraembryonic tissues of some carrier female mice.
T11084	13960-13962	IN	denotes	In
T11085	13978-13985	VBZ	denotes	appears
T11086	13963-13971	NN	denotes	addition
T11087	13971-13973	,	denotes	,
T11088	13973-13977	NN	denotes	Atrx
T11089	13986-13988	TO	denotes	to
T11090	13989-13995	VB	denotes	escape
T11091	13996-14005	VBN	denotes	imprinted
T11092	14008-14018	NN	denotes	chromosome
T11093	14006-14007	NN	denotes	X
T11094	14007-14008	HYPH	denotes	-
T11095	14019-14031	NN	denotes	inactivation
T11096	14032-14034	IN	denotes	in
T11097	14035-14038	DT	denotes	the
T11098	14054-14061	NNS	denotes	tissues
T11099	14039-14053	JJ	denotes	extraembryonic
T11100	14062-14064	IN	denotes	of
T11101	14065-14069	DT	denotes	some
T11102	14085-14089	NNS	denotes	mice
T11103	14070-14077	NN	denotes	carrier
T11104	14078-14084	JJ	denotes	female
T11105	14089-14090	.	denotes	.
T7194	11-13	PRP	denotes	We
T7195	14-26	VBD	denotes	investigated
T7196	27-30	DT	denotes	the
T7197	31-35	NN	denotes	role
T7198	36-38	IN	denotes	of
T7199	39-42	DT	denotes	the
T7200	48-55	NN	denotes	protein
T7201	43-47	NN	denotes	Atrx
T7202	56-58	IN	denotes	in
T7203	59-64	NN	denotes	mouse
T7204	65-76	NN	denotes	development
T7205	76-77	.	denotes	.
T7206	77-236	sentence	denotes	By using a conditional knockout approach, we ablated the full-length Atrx protein first in ES cells and embryoid bodies, and then in developing mouse embryos.
T7207	78-80	IN	denotes	By
T7208	123-130	VBD	denotes	ablated
T7209	81-86	VBG	denotes	using
T7210	87-88	DT	denotes	a
T7211	110-118	NN	denotes	approach
T7212	89-100	JJ	denotes	conditional
T7213	101-109	NN	denotes	knockout
T7214	118-120	,	denotes	,
T7215	120-122	PRP	denotes	we
T7216	131-134	DT	denotes	the
T7217	152-159	NN	denotes	protein
T7218	135-139	JJ	denotes	full
T7219	140-146	NN	denotes	length
T7220	139-140	HYPH	denotes	-
T7221	147-151	NN	denotes	Atrx
T7222	160-165	RB	denotes	first
T7223	166-168	IN	denotes	in
R4510	T7194	T7195	nsubj	We,investigated
R4511	T7196	T7197	det	the,role
R4512	T7197	T7195	dobj	role,investigated
R4513	T7198	T7197	prep	of,role
R4514	T7199	T7200	det	the,protein
R4515	T7200	T7198	pobj	protein,of
R4516	T7201	T7200	compound	Atrx,protein
R4517	T7202	T7197	prep	in,role
R4518	T7203	T7204	compound	mouse,development
R4519	T7204	T7202	pobj	development,in
R4520	T7205	T7195	punct	.,investigated
R4521	T7207	T7208	prep	By,ablated
R4522	T7209	T7207	pcomp	using,By
R4523	T7210	T7211	det	a,approach
R4524	T7211	T7209	dobj	approach,using
R4525	T7212	T7211	amod	conditional,approach
R4526	T7213	T7211	compound	knockout,approach
R4527	T7214	T7208	punct	", ",ablated
R4528	T7215	T7208	nsubj	we,ablated
R4529	T7216	T7217	det	the,protein
R4530	T7217	T7208	dobj	protein,ablated
R4531	T7218	T7219	amod	full,length
R4532	T7219	T7217	compound	length,protein
R4533	T7220	T7219	punct	-,length
R4534	T7221	T7217	compound	Atrx,protein
R4535	T7222	T7223	advmod	first,in
R4536	T7223	T7208	prep	in,ablated
R4537	T7224	T7225	compound	ES,cells
R4538	T7225	T7223	pobj	cells,in
R4539	T7226	T7225	cc	and,cells
R4540	T7227	T7228	amod	embryoid,bodies
R4541	T7228	T7225	conj	bodies,cells
R4542	T7229	T7223	punct	", ",in
R4543	T7230	T7223	cc	and,in
R4544	T7231	T7232	advmod	then,in
R4545	T7232	T7223	conj	in,in
R4546	T7233	T7234	amod	developing,embryos
R4547	T7234	T7232	pobj	embryos,in
R4548	T7235	T7234	compound	mouse,embryos
R4549	T7236	T7208	punct	.,ablated
R4550	T7416	T7415	prep	in,Atrx
R4551	T7417	T7418	compound	ES,Cells
R4552	T7418	T7416	pobj	Cells,in
R4553	T7420	T7421	amod	Atrxnull,ES
R4554	T7421	T7422	compound	ES,cells
R4555	T7422	T7423	nsubjpass	cells,recovered
R4556	T7424	T7423	aux	could,recovered
R4557	T7425	T7423	neg	not,recovered
R4558	T7426	T7423	auxpass	be,recovered
R4559	T7427	T7423	agent	by,recovered
R4560	T7428	T7429	amod	direct,targeting
R4561	T7429	T7427	pobj	targeting,by
R4562	T7430	T7423	cc	and,recovered
R4563	T7431	T7432	auxpass	were,generated
R4564	T7432	T7423	conj	generated,recovered
R4565	T7433	T7432	advmod	eventually,generated
R4566	T7434	T7432	prep	by,generated
R4567	T7435	T7434	pcomp	adopting,by
R4568	T7436	T7437	det	a,approach
R4569	T7437	T7435	dobj	approach,adopting
R4570	T7438	T7439	amod	conditional,targeting
R4571	T7439	T7437	compound	targeting,approach
R4572	T7440	T7423	punct	.,recovered
R4573	T7442	T7443	nsubj	This,is
R4574	T7444	T7443	acomp	consistent,is
R4575	T7445	T7444	prep	with,consistent
R4576	T7446	T7447	poss	our,observation
R4577	T7447	T7445	pobj	observation,with
R4578	T7448	T7449	mark	that,is
R4579	T7449	T7447	advcl	is,observation
R4580	T7450	T7449	nsubj	Atrx,is
R4581	T7451	T7452	advmod	highly,expressed
R4582	T7452	T7449	acomp	expressed,is
R4583	T7453	T7449	prep	in,is
R4584	T7454	T7455	compound	ES,cells
R4585	T7455	T7453	pobj	cells,in
R4586	T7456	T7449	punct	", ",is
R4587	T7457	T7449	cc	and,is
R4588	T7458	T7459	mark	that,imparts
R4589	T7459	T7449	conj	imparts,is
R4590	T7460	T7461	det	the,absence
R4591	T7461	T7459	nsubj	absence,imparts
R4592	T7462	T7461	prep	of,absence
R4593	T7463	T7464	amod	full,length
R4594	T7464	T7466	compound	length,Atrx
R4595	T7465	T7464	punct	-,length
R4596	T7466	T7462	pobj	Atrx,of
R4597	T7467	T7468	det	a,disadvantage
R4598	T7468	T7459	dobj	disadvantage,imparts
R4599	T7469	T7468	compound	growth,disadvantage
R4600	T7470	T7459	advcl	relative,imparts
R4601	T7471	T7470	prep	to,relative
R4602	T7472	T7471	pobj	cells,to
R4603	T7473	T7472	acl	bearing,cells
R4604	T7474	T7475	det	a,allele
R4605	T7475	T7473	dobj	allele,bearing
R4606	T7476	T7475	amod	functional,allele
R4607	T7477	T7475	compound	Atrx,allele
R4608	T7478	T7443	punct	.,is
R4609	T7480	T7481	prep	At,is
R4610	T7482	T7480	amod	present,At
R4611	T7483	T7481	punct	", ",is
R4612	T7484	T7485	det	the,cause
R4613	T7485	T7481	nsubj	cause,is
R4614	T7486	T7485	prep	of,cause
R4615	T7487	T7488	det	the,delay
R4616	T7488	T7486	pobj	delay,of
R4617	T7489	T7488	amod	proliferative,delay
R4618	T7490	T7488	prep	in,delay
R4619	T7491	T7492	amod	Atrxnull,cells
R4620	T7492	T7490	pobj	cells,in
R4621	T7493	T7492	compound	ES,cells
R4622	T7494	T7481	neg	not,is
R4623	T7495	T7481	acomp	known,is
R4624	T7496	T7481	punct	.,is
R4625	T7498	T7499	advmod	Interestingly,demonstrated
R4626	T7500	T7499	punct	", ",demonstrated
R4627	T7501	T7499	nsubj	we,demonstrated
R4628	T7502	T7503	mark	that,regulated
R4629	T7503	T7499	ccomp	regulated,demonstrated
R4630	T7504	T7503	nsubjpass	apoptosis,regulated
R4631	T7505	T7503	auxpass	is,regulated
R4632	T7506	T7503	neg	not,regulated
R4633	T7507	T7503	advmod	significantly,regulated
R4634	T7508	T7503	advmod	up,regulated
R4635	T7509	T7503	punct	-,regulated
R4636	T7510	T7503	prep	in,regulated
R4637	T7511	T7512	compound	ES,cells
R4638	T7512	T7510	pobj	cells,in
R4639	T7513	T7512	acl	lacking,cells
R4640	T7514	T7513	dobj	Atrx,lacking
R4641	T7515	T7503	cc	and,regulated
R4642	T7516	T7503	conj	is,regulated
R4643	T7517	T7518	advmod	only,mildly
R4644	T7518	T7519	advmod	mildly,elevated
R4645	T7519	T7516	acomp	elevated,is
R4646	T7520	T7516	prep	in,is
R4647	T7521	T7522	amod	Atrxnull,embryos
R4648	T7522	T7520	pobj	embryos,in
R4649	T7523	T7524	nummod	7.5,dpc
R4650	T7524	T7522	compound	dpc,embryos
R4651	T7525	T7522	compound	mouse,embryos
R4652	T7526	T7499	punct	.,demonstrated
R4653	T7528	T7529	prep	In,shown
R4654	T7530	T7528	pobj	contrast,In
R4655	T7531	T7529	punct	", ",shown
R4656	T7532	T7529	nsubjpass	it,shown
R4657	T7533	T7529	auxpass	was,shown
R4658	T7534	T7529	advmod	recently,shown
R4659	T7535	T7536	mark	that,increased
R4660	T7536	T7529	ccomp	increased,shown
R4661	T7537	T7538	det	the,loss
R4662	T7538	T7536	nsubj	loss,increased
R4663	T7539	T7538	prep	of,loss
R4664	T7540	T7539	pobj	Atrx,of
R4665	T7541	T7536	advmod	markedly,increased
R4666	T7542	T7543	det	the,population
R4667	T7543	T7536	dobj	population,increased
R4668	T7544	T7543	amod	apoptotic,population
R4669	T7545	T7536	prep	in,increased
R4670	T7546	T7547	det	the,cells
R4671	T7547	T7545	pobj	cells,in
R4672	T7548	T7547	amod	differentiating,cells
R4673	T7549	T7547	prep	of,cells
R4674	T7550	T7551	det	the,cortex
R4675	T7551	T7549	pobj	cortex,of
R4676	T7552	T7551	amod	embryonic,cortex
R4677	T7553	T7551	cc	and,cortex
R4678	T7554	T7555	amod	postnatal,hippocampus
R4679	T7555	T7551	conj	hippocampus,cortex
R4680	T7556	T7536	punct	", ",increased
R4681	T7557	T7558	advmod	when,ablated
R4682	T7558	T7536	advcl	ablated,increased
R4683	T7559	T7560	compound	Atrx,expression
R4684	T7560	T7558	nsubjpass	expression,ablated
R4685	T7561	T7558	auxpass	was,ablated
R4686	T7562	T7558	prep	in,ablated
R4687	T7563	T7564	det	the,forebrain
R4688	T7564	T7562	pobj	forebrain,in
R4689	T7565	T7564	amod	developing,forebrain
R4690	T7566	T7564	compound	mouse,forebrain
R4691	T7567	T7536	advcl	using,increased
R4692	T7568	T7569	det	the,allele
R4693	T7569	T7567	dobj	allele,using
R4694	T7570	T7569	compound	Atrx flox,allele
R4695	T7571	T7569	acl	described,allele
R4696	T7572	T7571	advmod	here,described
R4697	T7573	T7574	punct	[,20
R4698	T7574	T7529	parataxis	20,shown
R4699	T7575	T7574	punct	],20
R4700	T7576	T7529	punct	.,shown
R4701	T7578	T7579	det	The,protein
R4702	T7579	T7582	nsubjpass	protein,shown
R4703	T7580	T7579	amod	human,protein
R4704	T7581	T7579	compound	ATRX,protein
R4705	T7583	T7582	aux	has,shown
R4706	T7584	T7582	auxpass	been,shown
R4707	T7585	T7586	aux	to,associate
R4708	T7586	T7582	xcomp	associate,shown
R4709	T7587	T7586	prep	in,associate
R4710	T7588	T7589	det	a,complex
R4711	T7589	T7587	pobj	complex,in
R4712	T7590	T7586	prep	with,associate
R4713	T7591	T7590	pobj	Daxx,with
R4714	T7592	T7593	punct	[,8
R4715	T7593	T7591	parataxis	8,Daxx
R4716	T7594	T7593	punct	],8
R4717	T7595	T7591	punct	", ",Daxx
R4718	T7596	T7597	det	a,protein
R4719	T7597	T7591	appos	protein,Daxx
R4720	T7598	T7599	dep	that,implicated
R4721	T7599	T7597	relcl	implicated,protein
R4722	T7600	T7599	aux	has,implicated
R4723	T7601	T7599	auxpass	been,implicated
R4724	T7602	T7599	prep	in,implicated
R4725	T7603	T7604	amod	multiple,pathways
R4726	T7604	T7602	pobj	pathways,in
R4727	T7605	T7599	prep	for,implicated
R4728	T7606	T7607	det	the,regulation
R4729	T7607	T7605	pobj	regulation,for
R4730	T7608	T7607	prep	of,regulation
R4731	T7609	T7608	pobj	apoptosis,of
R4732	T7610	T7611	punct	[,21
R4733	T7611	T7582	parataxis	21,shown
R4734	T7612	T7611	punct	],21
R4735	T7613	T7582	punct	.,shown
R4736	T7615	T7616	nsubj	It,is
R4737	T7617	T7616	acomp	possible,is
R4738	T7618	T7619	mark	that,triggered
R4739	T7619	T7616	ccomp	triggered,is
R4740	T7620	T7619	nsubj	disruption,triggered
R4741	T7621	T7620	prep	of,disruption
R4742	T7622	T7623	det	the,complex
R4743	T7623	T7621	pobj	complex,of
R4744	T7624	T7623	compound	mouse,complex
R4745	T7625	T7626	compound	Atrx,Daxx
R4746	T7626	T7623	compound	Daxx,complex
R4747	T7627	T7626	punct	-,Daxx
R4748	T7628	T7620	punct	(,disruption
R4749	T7629	T7620	prep	by,disruption
R4750	T7630	T7629	pobj	ablation,by
R4751	T7631	T7630	prep	of,ablation
R4752	T7632	T7633	det	the,protein
R4753	T7633	T7631	pobj	protein,of
R4754	T7634	T7633	compound	Atrx,protein
R4755	T7635	T7619	punct	),triggered
R4756	T7636	T7619	aux	could,triggered
R4757	T7637	T7619	aux	have,triggered
R4758	T7638	T7639	det	a,response
R4759	T7639	T7619	dobj	response,triggered
R4760	T7640	T7639	amod	universal,response
R4761	T7641	T7639	amod	proapoptotic,response
R4762	T7642	T7616	punct	.,is
R4763	T7644	T7645	advmod	However,demonstrate
R4764	T7646	T7645	punct	", ",demonstrate
R4765	T7647	T7648	poss	our,observations
R4766	T7648	T7645	nsubj	observations,demonstrate
R4767	T7649	T7648	prep	in,observations
R4768	T7650	T7651	compound	ES,cells
R4769	T7651	T7649	pobj	cells,in
R4770	T7652	T7653	mark	that,is
R4771	T7653	T7645	ccomp	is,demonstrate
R4772	T7654	T7655	det	the,induction
R4773	T7655	T7653	nsubj	induction,is
R4774	T7656	T7655	prep	of,induction
R4775	T7657	T7656	pobj	apoptosis,of
R4776	T7658	T7653	neg	not,is
R4777	T7659	T7660	det	an,response
R4778	T7660	T7653	attr	response,is
R4779	T7661	T7660	amod	automatic,response
R4780	T7662	T7660	acl	triggered,response
R4781	T7663	T7662	agent	by,triggered
R4782	T7664	T7665	det	the,removal
R4783	T7665	T7663	pobj	removal,by
R4784	T7666	T7665	prep	of,removal
R4785	T7667	T7666	pobj	Atrx,of
R4786	T7668	T7662	prep	in,triggered
R4787	T7669	T7670	det	all,types
R4788	T7670	T7668	pobj	types,in
R4789	T7671	T7670	compound	cell,types
R4790	T7672	T7645	punct	", ",demonstrate
R4791	T7673	T7645	cc	and,demonstrate
R4792	T7674	T7645	conj	suggest,demonstrate
R4793	T7675	T7676	mark	that,reflect
R4794	T7676	T7674	ccomp	reflect,suggest
R4795	T7677	T7678	det	the,apoptosis
R4796	T7678	T7676	nsubj	apoptosis,reflect
R4797	T7679	T7678	amod	inappropriate,apoptosis
R4798	T7680	T7678	acl	observed,apoptosis
R4799	T7681	T7680	prep	in,observed
R4800	T7682	T7683	det	the,forebrain
R4801	T7683	T7681	pobj	forebrain,in
R4802	T7684	T7685	compound	Atrx,mutant
R4803	T7685	T7683	compound	mutant,forebrain
R4804	T7686	T7685	punct	-,mutant
R4805	T7687	T7676	aux	may,reflect
R4806	T7688	T7689	det	a,requirement
R4807	T7689	T7676	dobj	requirement,reflect
R4808	T7690	T7689	prep	for,requirement
R4809	T7691	T7690	pobj	Atrx,for
R4810	T7692	T7689	prep	during,requirement
R4811	T7693	T7694	amod	terminal,differentiation
R4812	T7694	T7692	pobj	differentiation,during
R4813	T7695	T7645	punct	.,demonstrate
R4824	T8323	T8324	det	An,Role
R4825	T8325	T8324	amod	Unexpected,Role
R4826	T8326	T8324	prep	for,Role
R4827	T8327	T8326	pobj	Atrx,for
R4828	T8328	T8324	prep	in,Role
R4829	T8329	T8328	pobj	Development,in
R4830	T8330	T8329	prep	of,Development
R4831	T8331	T8332	det	the,Trophoblast
R4832	T8332	T8330	pobj	Trophoblast,of
R4833	T8333	T8332	compound	Mouse,Trophoblast
R4834	T8335	T8336	nsubj	We,show
R4835	T8337	T8338	mark	that,are
R4836	T8338	T8336	ccomp	are,show
R4837	T8339	T8340	amod	Atrxnull,mice
R4838	T8340	T8338	nsubj	mice,are
R4839	T8341	T8340	amod	male,mice
R4840	T8342	T8338	neg	not,are
R4841	T8343	T8338	acomp	viable,are
R4842	T8344	T8338	cc	and,are
R4843	T8345	T8346	nsubj	embryos,die
R4844	T8346	T8338	conj	die,are
R4845	T8347	T8346	prep	by,die
R4846	T8348	T8349	quantmod	around,9.5
R4847	T8349	T8350	nummod	9.5,dpc
R4848	T8350	T8347	pobj	dpc,by
R4849	T8351	T8336	punct	.,show
R4850	T8353	T8354	prep	Before,exhibit
R4851	T8355	T8353	pobj	death,Before
R4852	T8356	T8354	punct	", ",exhibit
R4853	T8357	T8358	amod	Atrxnull,embryos
R4854	T8358	T8354	nsubj	embryos,exhibit
R4855	T8359	T8360	det	a,index
R4856	T8360	T8354	dobj	index,exhibit
R4857	T8361	T8362	advmod	markedly,reduced
R4858	T8362	T8360	amod	reduced,index
R4859	T8363	T8360	amod	mitotic,index
R4860	T8364	T8354	punct	", ",exhibit
R4861	T8365	T8354	advcl	suggesting,exhibit
R4862	T8366	T8367	det	a,defect
R4863	T8367	T8365	dobj	defect,suggesting
R4864	T8368	T8367	amod	proliferative,defect
R4865	T8369	T8354	punct	.,exhibit
R4866	T8371	T8372	mark	Although,appears
R4867	T8372	T8379	advcl	appears,display
R4868	T8373	T8374	det	the,compartment
R4869	T8374	T8372	nsubj	compartment,appears
R4870	T8375	T8374	amod	embryonic,compartment
R4871	T8376	T8374	prep	of,compartment
R4872	T8377	T8378	det	the,conceptus
R4873	T8378	T8376	pobj	conceptus,of
R4874	T8380	T8381	advmod	initially,normal
R4875	T8381	T8372	oprd	normal,appears
R4876	T8382	T8379	punct	", ",display
R4877	T8383	T8379	prep	by,display
R4878	T8384	T8385	nummod	7.5,dpc
R4879	T8385	T8383	pobj	dpc,by
R4880	T8386	T8387	amod	Atrxnull,embryos
R4881	T8387	T8379	nsubj	embryos,display
R4882	T8388	T8379	dobj	abnormalities,display
R4883	T8389	T8388	prep	in,abnormalities
R4884	T8390	T8389	pobj	development,in
R4885	T8391	T8390	prep	of,development
R4886	T8392	T8393	det	the,trophoblast
R4887	T8393	T8391	pobj	trophoblast,of
R4888	T8394	T8388	punct	", ",abnormalities
R4889	T8395	T8388	prep	including,abnormalities
R4890	T8396	T8397	det	a,depletion
R4891	T8397	T8395	pobj	depletion,including
R4892	T8398	T8397	prep	in,depletion
R4893	T8399	T8400	det	the,population
R4894	T8400	T8398	pobj	population,in
R4895	T8401	T8400	prep	of,population
R4896	T8402	T8401	pobj	TGCs,of
R4897	T8403	T8402	acl	surrounding,TGCs
R4898	T8404	T8405	det	the,conceptus
R4899	T8405	T8403	dobj	conceptus,surrounding
R4900	T8406	T8397	cc	and,depletion
R4901	T8407	T8408	det	a,reduction
R4902	T8408	T8397	conj	reduction,depletion
R4903	T8409	T8408	prep	in,reduction
R4904	T8410	T8411	det	the,size
R4905	T8411	T8409	pobj	size,in
R4906	T8412	T8411	prep	of,size
R4907	T8413	T8414	det	the,cone
R4908	T8414	T8412	pobj	cone,of
R4909	T8415	T8414	amod	ectoplacental,cone
R4910	T8416	T8414	punct	", ",cone
R4911	T8417	T8418	dep	which,contains
R4912	T8418	T8414	relcl	contains,cone
R4913	T8419	T8420	det	the,precursors
R4914	T8420	T8418	dobj	precursors,contains
R4915	T8421	T8420	nmod	diploid,precursors
R4916	T8422	T8420	amod	giant,precursors
R4917	T8423	T8420	compound	cell,precursors
R4918	T8424	T8425	punct	[,22
R4919	T8425	T8379	parataxis	22,display
R4920	T8426	T8425	punct	],22
R4921	T8427	T8379	punct	.,display
R4922	T8429	T8430	nsubj	TGCs,are
R4923	T8431	T8432	advmod	highly,differentiated
R4924	T8432	T8433	amod	differentiated,cells
R4925	T8433	T8430	attr	cells,are
R4926	T8434	T8433	punct	", ",cells
R4927	T8435	T8433	amod	postmitotic,cells
R4928	T8436	T8437	dep	that,form
R4929	T8437	T8433	relcl	form,cells
R4930	T8438	T8437	advmod	ultimately,form
R4931	T8439	T8440	det	an,layer
R4932	T8440	T8437	dobj	layer,form
R4933	T8441	T8440	amod	epithelial,layer
R4934	T8442	T8437	prep	at,form
R4935	T8443	T8444	det	the,periphery
R4936	T8444	T8442	pobj	periphery,at
R4937	T8445	T8444	prep	of,periphery
R4938	T8446	T8447	det	the,placenta
R4939	T8447	T8445	pobj	placenta,of
R4940	T8448	T8437	punct	", ",form
R4941	T8449	T8450	dep	which,interfaces
R4942	T8450	T8437	ccomp	interfaces,form
R4943	T8451	T8450	prep	with,interfaces
R4944	T8452	T8453	det	the,cells
R4945	T8453	T8451	pobj	cells,with
R4946	T8454	T8453	amod	maternal,cells
R4947	T8455	T8453	prep	of,cells
R4948	T8456	T8457	det	the,decidua
R4949	T8457	T8455	pobj	decidua,of
R4950	T8458	T8459	punct	[,23
R4951	T8459	T8430	parataxis	23,are
R4952	T8460	T8459	punct	],23
R4953	T8461	T8430	punct	.,are
R4954	T8463	T8464	det	These,cells
R4955	T8464	T8467	nsubj	cells,are
R4956	T8465	T8466	advmod	highly,invasive
R4957	T8466	T8464	amod	invasive,cells
R4958	T8468	T8467	acomp	important,are
R4959	T8469	T8468	prep	for,important
R4960	T8470	T8469	pcomp	mediating,for
R4961	T8471	T8472	amod	initial,invasion
R4962	T8472	T8470	dobj	invasion,mediating
R4963	T8473	T8472	prep	of,invasion
R4964	T8474	T8475	det	the,tissue
R4965	T8475	T8473	pobj	tissue,of
R4966	T8476	T8475	amod	uterine,tissue
R4967	T8477	T8467	punct	", ",are
R4968	T8478	T8467	cc	but,are
R4969	T8479	T8480	auxpass	are,involved
R4970	T8480	T8467	conj	involved,are
R4971	T8481	T8480	advmod	also,involved
R4972	T8482	T8480	prep	in,involved
R4973	T8483	T8482	pcomp	remodelling,in
R4974	T8484	T8485	det	the,decidua
R4975	T8485	T8483	dobj	decidua,remodelling
R4976	T8486	T8485	amod	maternal,decidua
R4977	T8487	T8483	prep	after,remodelling
R4978	T8488	T8487	pobj	implantation,after
R4979	T8489	T8482	cc	and,in
R4980	T8490	T8482	conj	in,in
R4981	T8491	T8490	pcomp	secreting,in
R4982	T8492	T8491	dobj	hormones,secreting
R4983	T8493	T8494	dep	that,regulate
R4984	T8494	T8492	relcl	regulate,hormones
R4985	T8495	T8496	amod	fetal,growth
R4986	T8496	T8494	dobj	growth,regulate
R4987	T8497	T8495	cc	and,fetal
R4988	T8498	T8495	conj	maternal,fetal
R4989	T8499	T8500	punct	[,24
R4990	T8500	T8480	parataxis	24,involved
R4991	T8501	T8500	punct	],24
R4992	T8502	T8467	punct	.,are
R4993	T8504	T8505	mark	Since,appear
R4994	T8505	T8508	advcl	appear,is
R4995	T8506	T8507	amod	Atrxnull,embryos
R4996	T8507	T8505	nsubj	embryos,appear
R4997	T8509	T8510	aux	to,implant
R4998	T8510	T8505	xcomp	implant,appear
R4999	T8511	T8510	advmod	normally,implant
R5000	T8512	T8508	punct	", ",is
R5001	T8513	T8508	nsubj	lethality,is
R5002	T8514	T8508	acomp	likely,is
R5003	T8515	T8516	aux	to,arise
R5004	T8516	T8514	xcomp	arise,likely
R5005	T8517	T8516	prep	due,arise
R5006	T8518	T8517	pcomp	to,due
R5007	T8519	T8520	det	a,failure
R5008	T8520	T8517	pobj	failure,due
R5009	T8521	T8520	prep	of,failure
R5010	T8522	T8523	compound	TGC,function
R5011	T8523	T8521	pobj	function,of
R5012	T8524	T8516	advmod	later,arise
R5013	T8525	T8516	prep	during,arise
R5014	T8526	T8525	pobj	development,during
R5015	T8527	T8508	punct	.,is
R5016	T8529	T8530	amod	Embryonic,lethality
R5017	T8530	T8531	nsubj	lethality,was
R5018	T8532	T8530	prep	in,lethality
R5019	T8533	T8532	pobj	mice,in
R5020	T8534	T8530	prep	in,lethality
R5021	T8535	T8536	det	the,absence
R5022	T8536	T8534	pobj	absence,in
R5023	T8537	T8536	prep	of,absence
R5024	T8538	T8537	pobj	Atrx,of
R5025	T8539	T8540	det	a,finding
R5026	T8540	T8531	attr	finding,was
R5027	T8541	T8540	amod	surprising,finding
R5028	T8542	T8531	punct	", ",was
R5029	T8543	T8544	mark	as,been
R5030	T8544	T8531	advcl	been,was
R5031	T8545	T8544	expl	there,been
R5032	T8546	T8544	aux	had,been
R5033	T8547	T8548	det	no,suggestion
R5034	T8548	T8544	attr	suggestion,been
R5035	T8549	T8548	prep	of,suggestion
R5036	T8550	T8551	amod	foetal,loss
R5037	T8551	T8549	pobj	loss,of
R5038	T8552	T8544	prep	in,been
R5039	T8553	T8554	det	the,syndrome
R5040	T8554	T8552	pobj	syndrome,in
R5041	T8555	T8554	amod	human,syndrome
R5042	T8556	T8557	compound	ATR,X
R5043	T8557	T8554	compound	X,syndrome
R5044	T8558	T8557	punct	-,X
R5045	T8559	T8531	punct	.,was
R5046	T8561	T8562	nsubj	It,is
R5047	T8563	T8562	acomp	possible,is
R5048	T8564	T8565	mark	that,is
R5049	T8565	T8562	advcl	is,is
R5050	T8566	T8567	det	the,role
R5051	T8567	T8565	nsubj	role,is
R5052	T8568	T8567	prep	of,role
R5053	T8569	T8568	pobj	Atrx,of
R5054	T8570	T8567	prep	in,role
R5055	T8571	T8572	det	the,trophoblast
R5056	T8572	T8570	pobj	trophoblast,in
R5057	T8573	T8565	acomp	specific,is
R5058	T8574	T8573	prep	to,specific
R5059	T8575	T8574	pobj	mice,to
R5060	T8576	T8565	cc	and,is
R5061	T8577	T8578	mark	that,has
R5062	T8578	T8565	conj	has,is
R5063	T8579	T8578	nsubj	ATRX,has
R5064	T8580	T8581	det	no,role
R5065	T8581	T8578	dobj	role,has
R5066	T8582	T8578	cc	or,has
R5067	T8583	T8578	conj	is,has
R5068	T8584	T8583	acomp	redundant,is
R5069	T8585	T8578	prep	in,has
R5070	T8586	T8587	det	the,trophoblast
R5071	T8587	T8585	pobj	trophoblast,in
R5072	T8588	T8587	amod	human,trophoblast
R5073	T8589	T8562	punct	.,is
R5074	T8591	T8592	advmod	Indeed,is
R5075	T8593	T8592	punct	", ",is
R5076	T8594	T8595	det	the,weight
R5077	T8595	T8592	nsubj	weight,is
R5078	T8596	T8595	compound	birth,weight
R5079	T8597	T8595	prep	of,weight
R5080	T8598	T8597	pobj	babies,of
R5081	T8599	T8598	prep	with,babies
R5082	T8600	T8601	compound	ATR,X
R5083	T8601	T8603	compound	X,syndrome
R5084	T8602	T8601	punct	-,X
R5085	T8603	T8599	pobj	syndrome,with
R5086	T8604	T8592	advmod	usually,is
R5087	T8605	T8592	acomp	normal,is
R5088	T8606	T8592	punct	.,is
R5089	T8608	T8609	det	An,explanation
R5090	T8609	T8611	nsubj	explanation,is
R5091	T8610	T8609	amod	alternative,explanation
R5092	T8612	T8609	prep	for,explanation
R5093	T8613	T8614	det	the,phenotype
R5094	T8614	T8612	pobj	phenotype,for
R5095	T8615	T8616	advmod	unexpectedly,severe
R5096	T8616	T8614	amod	severe,phenotype
R5097	T8617	T8618	nsubj	we,observed
R5098	T8618	T8614	advcl	observed,phenotype
R5099	T8619	T8618	prep	in,observed
R5100	T8620	T8619	pobj	mice,in
R5101	T8621	T8622	mark	that,ablates
R5102	T8622	T8611	ccomp	ablates,is
R5103	T8623	T8624	det	the,deletion
R5104	T8624	T8622	nsubj	deletion,ablates
R5105	T8625	T8624	compound	Atrx Δ18Δneo,deletion
R5106	T8626	T8624	acl	generated,deletion
R5107	T8627	T8626	prep	by,generated
R5108	T8628	T8629	compound	Cre,recombination
R5109	T8629	T8627	pobj	recombination,by
R5110	T8630	T8622	advmod	completely,ablates
R5111	T8631	T8632	amod	full,length
R5112	T8632	T8634	compound	length,protein
R5113	T8633	T8632	punct	-,length
R5114	T8634	T8622	dobj	protein,ablates
R5115	T8635	T8634	compound	Atrx,protein
R5116	T8636	T8637	punct	(,2E
R5117	T8637	T8611	parataxis	2E,is
R5118	T8638	T8637	compound	Figure,2E
R5119	T8639	T8637	punct	),2E
R5120	T8640	T8611	punct	.,is
R5121	T8642	T8643	prep	In,appear
R5122	T8644	T8642	pobj	contrast,In
R5123	T8645	T8643	punct	", ",appear
R5124	T8646	T8647	det	all,mutations
R5125	T8647	T8643	nsubj	mutations,appear
R5126	T8648	T8649	npadvmod	disease,causing
R5127	T8649	T8647	amod	causing,mutations
R5128	T8650	T8649	punct	-,causing
R5129	T8651	T8647	acl	characterised,mutations
R5130	T8652	T8651	prep	in,characterised
R5131	T8653	T8654	amod	human,pedigrees
R5132	T8654	T8652	pobj	pedigrees,in
R5133	T8655	T8656	compound	ATR,X
R5134	T8656	T8654	compound	X,pedigrees
R5135	T8657	T8656	punct	-,X
R5136	T8658	T8659	aux	to,give
R5137	T8659	T8643	xcomp	give,appear
R5138	T8660	T8659	dobj	rise,give
R5139	T8661	T8659	prep	to,give
R5140	T8662	T8663	amod	hypomorphic,alleles
R5141	T8663	T8661	pobj	alleles,to
R5142	T8664	T8643	punct	.,appear
R5143	T8666	T8667	det	Some,protein
R5144	T8667	T8672	nsubjpass	protein,detected
R5145	T8668	T8669	amod	full,length
R5146	T8669	T8667	compound	length,protein
R5147	T8670	T8669	punct	-,length
R5148	T8671	T8667	compound	ATRX,protein
R5149	T8673	T8672	auxpass	is,detected
R5150	T8674	T8672	prep	in,detected
R5151	T8675	T8674	pobj	cases,in
R5152	T8676	T8675	acl	predicted,cases
R5153	T8677	T8678	aux	to,have
R5154	T8678	T8676	xcomp	have,predicted
R5155	T8679	T8680	compound	truncating,mutations
R5156	T8680	T8678	dobj	mutations,have
R5157	T8681	T8682	punct	(,data
R5158	T8682	T8672	parataxis	data,detected
R5159	T8683	T8682	dep	RJG,data
R5160	T8684	T8682	punct	", ",data
R5161	T8685	T8682	amod	unpublished,data
R5162	T8686	T8682	punct	),data
R5163	T8687	T8672	punct	", ",detected
R5164	T8688	T8672	cc	and,detected
R5165	T8689	T8690	amod	residual,activity
R5166	T8690	T8692	nsubjpass	activity,detected
R5167	T8691	T8690	compound	ATPase,activity
R5168	T8692	T8672	conj	detected,detected
R5169	T8693	T8690	prep	in,activity
R5170	T8694	T8695	compound	ATRX,immunoprecipitates
R5171	T8695	T8693	pobj	immunoprecipitates,in
R5172	T8696	T8692	aux	can,detected
R5173	T8697	T8692	auxpass	be,detected
R5174	T8698	T8692	prep	in,detected
R5175	T8699	T8700	compound	Epstein,Barr
R5176	T8700	T8702	compound	Barr,virus
R5177	T8701	T8700	punct	-,Barr
R5178	T8702	T8703	npadvmod	virus,transformed
R5179	T8703	T8705	amod	transformed,lymphocytes
R5180	T8704	T8703	punct	-,transformed
R5181	T8705	T8698	pobj	lymphocytes,in
R5182	T8706	T8705	prep	of,lymphocytes
R5183	T8707	T8708	det	all,patients
R5184	T8708	T8706	pobj	patients,of
R5185	T8709	T8708	amod	human,patients
R5186	T8710	T8708	acl	analysed,patients
R5187	T8711	T8710	prep	to,analysed
R5188	T8712	T8711	pobj	date,to
R5189	T8713	T8714	punct	(,A.
R5190	T8714	T8692	meta	A.,detected
R5191	T8715	T8714	nmod	Argentaro,A.
R5192	T8716	T8714	cc	and,A.
R5193	T8717	T8714	conj	M.,A.
R5194	T8718	T8717	nmod	Mitson,M.
R5195	T8719	T8717	punct	", ",M.
R5196	T8720	T8721	amod	unpublished,data
R5197	T8721	T8717	conj	data,M.
R5198	T8722	T8721	punct	),data
R5199	T8723	T8692	punct	.,detected
R5200	T8725	T8726	det	The,failure
R5201	T8726	T8727	nsubj	failure,suggests
R5202	T8728	T8729	aux	to,observe
R5203	T8729	T8726	acl	observe,failure
R5204	T8730	T8731	det	a,allele
R5205	T8731	T8729	dobj	allele,observe
R5206	T8732	T8733	advmod	truly,null
R5207	T8733	T8731	amod	null,allele
R5208	T8734	T8731	compound	ATRX,allele
R5209	T8735	T8729	prep	among,observe
R5210	T8736	T8737	amod	human,patients
R5211	T8737	T8735	pobj	patients,among
R5212	T8738	T8727	advmod	strongly,suggests
R5213	T8739	T8740	mark	that,is
R5214	T8740	T8727	ccomp	is,suggests
R5215	T8741	T8740	punct	", ",is
R5216	T8742	T8740	prep	as,is
R5217	T8743	T8742	prep	in,as
R5218	T8744	T8745	det	the,mouse
R5219	T8745	T8743	pobj	mouse,in
R5220	T8746	T8740	punct	", ",is
R5221	T8747	T8748	det	the,absence
R5222	T8748	T8740	nsubj	absence,is
R5223	T8749	T8748	amod	complete,absence
R5224	T8750	T8748	prep	of,absence
R5225	T8751	T8752	compound	ATRX,protein
R5226	T8752	T8750	pobj	protein,of
R5227	T8753	T8740	acomp	incompatible,is
R5228	T8754	T8753	prep	with,incompatible
R5229	T8755	T8756	amod	human,survival
R5230	T8756	T8754	pobj	survival,with
R5231	T8757	T8756	amod	fetal,survival
R5232	T8758	T8727	punct	.,suggests
R5233	T8760	T8761	mark	While,revealed
R5234	T8761	T8765	advcl	revealed,is
R5235	T8762	T8763	det	this,study
R5236	T8763	T8761	nsubj	study,revealed
R5237	T8764	T8761	aux	has,revealed
R5238	T8766	T8767	det	an,role
R5239	T8767	T8761	dobj	role,revealed
R5240	T8768	T8767	amod	unexpected,role
R5241	T8769	T8767	prep	for,role
R5242	T8770	T8769	pobj	Atrx,for
R5243	T8771	T8767	prep	in,role
R5244	T8772	T8773	det	the,trophectoderm
R5245	T8773	T8771	pobj	trophectoderm,in
R5246	T8774	T8773	amod	murine,trophectoderm
R5247	T8775	T8761	punct	", ",revealed
R5248	T8776	T8761	prep	as,revealed
R5249	T8777	T8778	det	a,result
R5250	T8778	T8776	pobj	result,as
R5251	T8779	T8778	prep	of,result
R5252	T8780	T8781	det	the,lethality
R5253	T8781	T8779	pobj	lethality,of
R5254	T8782	T8781	amod	early,lethality
R5255	T8783	T8781	acl	observed,lethality
R5256	T8784	T8783	prep	in,observed
R5257	T8785	T8786	amod	Atrxnull,embryos
R5258	T8786	T8784	pobj	embryos,in
R5259	T8787	T8765	nsubj	it,is
R5260	T8788	T8765	neg	not,is
R5261	T8789	T8765	acomp	possible,is
R5262	T8790	T8791	aux	to,rule
R5263	T8791	T8765	xcomp	rule,is
R5264	T8792	T8791	prt	out,rule
R5265	T8793	T8794	amod	other,roles
R5266	T8794	T8791	dobj	roles,rule
R5267	T8795	T8794	prep	for,roles
R5268	T8796	T8795	pobj	Atrx,for
R5269	T8797	T8794	prep	at,roles
R5270	T8798	T8799	amod	later,stages
R5271	T8799	T8797	pobj	stages,at
R5272	T8800	T8799	amod	developmental,stages
R5273	T8801	T8794	prep	in,roles
R5274	T8802	T8801	pobj	tissues,in
R5275	T8803	T8802	prep	of,tissues
R5276	T8804	T8805	det	the,embryo
R5277	T8805	T8803	pobj	embryo,of
R5278	T8806	T8805	amod	proper,embryo
R5279	T8807	T8765	punct	.,is
R5280	T8809	T8810	advmod	Indeed,show
R5281	T8811	T8810	punct	", ",show
R5282	T8812	T8810	nsubj	we,show
R5283	T8813	T8814	mark	that,is
R5284	T8814	T8810	ccomp	is,show
R5285	T8815	T8814	nsubj	Atrx,is
R5286	T8816	T8817	advmod	highly,expressed
R5287	T8817	T8814	acomp	expressed,is
R5288	T8818	T8814	prep	throughout,is
R5289	T8819	T8820	det	the,embryo
R5290	T8820	T8818	pobj	embryo,throughout
R5291	T8821	T8820	amod	entire,embryo
R5292	T8822	T8820	amod	developing,embryo
R5293	T8823	T8814	prep	at,is
R5294	T8824	T8825	nummod	7.5,dpc
R5295	T8825	T8823	pobj	dpc,at
R5296	T8826	T8827	punct	(,5B
R5297	T8827	T8814	parataxis	5B,is
R5298	T8828	T8827	compound	Figure,5B
R5299	T8829	T8827	punct	),5B
R5300	T8830	T8810	punct	", ",show
R5301	T8831	T8810	cc	and,show
R5302	T8832	T8833	nsubj	it,is
R5303	T8833	T8810	conj	is,show
R5304	T8834	T8833	acomp	likely,is
R5305	T8835	T8836	mark	that,turn
R5306	T8836	T8833	ccomp	turn,is
R5307	T8837	T8838	compound	Atrx,function
R5308	T8838	T8836	nsubj	function,turn
R5309	T8839	T8836	aux	will,turn
R5310	T8840	T8836	prt	out,turn
R5311	T8841	T8842	aux	to,be
R5312	T8842	T8836	xcomp	be,turn
R5313	T8843	T8842	acomp	important,be
R5314	T8844	T8843	prep	for,important
R5315	T8845	T8846	amod	other,tissues
R5316	T8846	T8844	pobj	tissues,for
R5317	T8847	T8846	amod	differentiating,tissues
R5318	T8848	T8810	punct	.,show
R5319	T8850	T8851	compound	Tetraploid,aggregation
R5320	T8851	T8852	compound	aggregation,experiments
R5321	T8852	T8853	nsubj	experiments,shed
R5322	T8854	T8852	punct	(,experiments
R5323	T8855	T8856	prep	in,rescued
R5324	T8856	T8852	relcl	rescued,experiments
R5325	T8857	T8855	pobj	which,in
R5326	T8858	T8859	compound	mutant,embryos
R5327	T8859	T8856	nsubjpass	embryos,rescued
R5328	T8860	T8856	auxpass	are,rescued
R5329	T8861	T8856	prep	with,rescued
R5330	T8862	T8863	amod	wild,type
R5331	T8863	T8865	nmod	type,tissues
R5332	T8864	T8863	punct	-,type
R5333	T8865	T8861	pobj	tissues,with
R5334	T8866	T8865	amod	extraembryonic,tissues
R5335	T8867	T8853	punct	),shed
R5336	T8868	T8853	aux	might,shed
R5337	T8869	T8870	amod	more,light
R5338	T8870	T8853	dobj	light,shed
R5339	T8871	T8853	prep	on,shed
R5340	T8872	T8873	det	the,role
R5341	T8873	T8871	pobj	role,on
R5342	T8874	T8873	prep	of,role
R5343	T8875	T8874	pobj	Atrx,of
R5344	T8876	T8873	prep	during,role
R5345	T8877	T8878	amod	later,development
R5346	T8878	T8876	pobj	development,during
R5347	T8879	T8878	compound	mouse,development
R5348	T8880	T8853	punct	", ",shed
R5349	T8881	T8853	cc	but,shed
R5350	T8882	T8883	det	these,issues
R5351	T8883	T8884	nsubjpass	issues,dissected
R5352	T8884	T8853	conj	dissected,shed
R5353	T8885	T8884	aux	can,dissected
R5354	T8886	T8884	auxpass	be,dissected
R5355	T8887	T8888	advmod	more,subtly
R5356	T8888	T8884	advmod	subtly,dissected
R5357	T8889	T8884	prep	by,dissected
R5358	T8890	T8889	pcomp	combining,by
R5359	T8891	T8892	det	the,allele
R5360	T8892	T8890	dobj	allele,combining
R5361	T8893	T8892	amod	conditional,allele
R5362	T8894	T8892	compound	Atrx flox,allele
R5363	T8895	T8896	dep	that,generated
R5364	T8896	T8892	relcl	generated,allele
R5365	T8897	T8896	nsubj	we,generated
R5366	T8898	T8896	aux	have,generated
R5367	T8899	T8890	prep	with,combining
R5368	T8900	T8901	amod	different,transgenes
R5369	T8901	T8899	pobj	transgenes,with
R5370	T8902	T8903	npadvmod	tissue,specific
R5371	T8903	T8901	amod	specific,transgenes
R5372	T8904	T8903	punct	-,specific
R5373	T8905	T8901	compound	Cre,transgenes
R5374	T8906	T8884	punct	.,dissected
R5375	T8908	T8909	mark	As,mentioned
R5376	T8909	T8910	advcl	mentioned,revealed
R5377	T8911	T8909	advmod	above,mentioned
R5378	T8912	T8910	punct	", ",revealed
R5379	T8913	T8914	det	this,approach
R5380	T8914	T8910	nsubj	approach,revealed
R5381	T8915	T8910	aux	has,revealed
R5382	T8916	T8910	advmod	already,revealed
R5383	T8917	T8918	det	a,role
R5384	T8918	T8910	dobj	role,revealed
R5385	T8919	T8918	amod	critical,role
R5386	T8920	T8918	prep	for,role
R5387	T8921	T8920	pobj	Atrx,for
R5388	T8922	T8918	prep	during,role
R5389	T8923	T8924	amod	neuronal,differentiation
R5390	T8924	T8922	pobj	differentiation,during
R5391	T8925	T8918	prep	in,role
R5392	T8926	T8927	amod	adult,mice
R5393	T8927	T8925	pobj	mice,in
R5394	T8928	T8929	punct	[,20
R5395	T8929	T8910	parataxis	20,revealed
R5396	T8930	T8929	punct	],20
R5397	T8931	T8910	punct	.,revealed
R5398	T8933	T8934	amod	Further,evidence
R5399	T8934	T8935	nsubjpass	evidence,provided
R5400	T8936	T8937	mark	that,required
R5401	T8937	T8934	acl	required,evidence
R5402	T8938	T8937	nsubjpass	Atrx,required
R5403	T8939	T8937	auxpass	is,required
R5404	T8940	T8937	advmod	also,required
R5405	T8941	T8937	prep	at,required
R5406	T8942	T8943	amod	later,stages
R5407	T8943	T8941	pobj	stages,at
R5408	T8944	T8943	prep	of,stages
R5409	T8945	T8946	compound	mouse,development
R5410	T8946	T8944	pobj	development,of
R5411	T8947	T8935	auxpass	is,provided
R5412	T8948	T8935	agent	by,provided
R5413	T8949	T8950	det	the,skewing
R5414	T8950	T8948	pobj	skewing,by
R5415	T8951	T8950	amod	observed,skewing
R5416	T8952	T8950	amod	dramatic,skewing
R5417	T8953	T8950	prep	against,skewing
R5418	T8954	T8955	nmod	Atrx,cells
R5419	T8955	T8953	pobj	cells,against
R5420	T8956	T8954	punct	-,Atrx
R5421	T8957	T8954	amod	negative,Atrx
R5422	T8958	T8950	prep	in,skewing
R5423	T8959	T8960	det	some,tissues
R5424	T8960	T8958	pobj	tissues,in
R5425	T8961	T8960	amod	somatic,tissues
R5426	T8962	T8960	prep	of,tissues
R5427	T8963	T8964	nmod	carrier,mice
R5428	T8964	T8962	pobj	mice,of
R5429	T8965	T8964	amod	female,mice
R5430	T8966	T8964	punct	", ",mice
R5431	T8967	T8968	poss	whose,tissues
R5432	T8968	T8969	dep	tissues,comprise
R5433	T8969	T8964	relcl	comprise,mice
R5434	T8970	T8969	advmod	initially,comprise
R5435	T8971	T8972	det	a,mosaic
R5436	T8972	T8969	dobj	mosaic,comprise
R5437	T8973	T8972	prep	of,mosaic
R5438	T8974	T8975	npadvmod	Atrx,positive
R5439	T8975	T8977	amod	positive,cells
R5440	T8976	T8975	punct	-,positive
R5441	T8977	T8973	pobj	cells,of
R5442	T8978	T8975	cc	and,positive
R5443	T8979	T8980	npadvmod	Atrx,negative
R5444	T8980	T8975	conj	negative,positive
R5445	T8981	T8980	punct	-,negative
R5446	T8982	T8969	prep	as,comprise
R5447	T8983	T8984	det	a,result
R5448	T8984	T8982	pobj	result,as
R5449	T8985	T8984	prep	of,result
R5450	T8986	T8987	amod	random,inactivation
R5451	T8987	T8985	pobj	inactivation,of
R5452	T8988	T8987	compound	X,inactivation
R5453	T8989	T8987	punct	-,inactivation
R5454	T8990	T8991	punct	(,M.
R5455	T8991	T8935	meta	M.,provided
R5456	T8992	T8991	nmod	Muers,M.
R5457	T8993	T8991	punct	", ",M.
R5458	T8994	T8991	amod	personal,M.
R5459	T8995	T8991	nmod	communication,M.
R5460	T8996	T8991	punct	),M.
R5461	T8997	T8935	punct	.,provided
R5462	T8999	T9000	nsubj	Atrx,joins
R5463	T9001	T9002	det	an,list
R5464	T9002	T9000	dobj	list,joins
R5465	T9003	T9002	amod	expanding,list
R5466	T9004	T9002	prep	of,list
R5467	T9005	T9006	compound	mouse,genes
R5468	T9006	T9004	pobj	genes,of
R5469	T9007	T9008	prep	for,results
R5470	T9008	T9002	relcl	results,list
R5471	T9009	T9007	pobj	which,for
R5472	T9010	T9011	amod	targeted,disruption
R5473	T9011	T9008	nsubj	disruption,results
R5474	T9012	T9008	prep	in,results
R5475	T9013	T9014	amod	peri-implantation,lethality
R5476	T9014	T9012	pobj	lethality,in
R5477	T9015	T9008	prep	as,results
R5478	T9016	T9017	det	a,result
R5479	T9017	T9015	pobj	result,as
R5480	T9018	T9017	prep	of,result
R5481	T9019	T9020	nmod	trophoblast,abnormalities
R5482	T9020	T9018	pobj	abnormalities,of
R5483	T9021	T9019	cc	or,trophoblast
R5484	T9022	T9019	conj	placental,trophoblast
R5485	T9023	T9024	punct	(,reviewed
R5486	T9024	T9000	parataxis	reviewed,joins
R5487	T9025	T9024	prep	in,reviewed
R5488	T9026	T9025	punct	[,in
R5489	T9027	T9025	pobj	25,in
R5490	T9028	T9024	punct	],reviewed
R5491	T9029	T9024	punct	),reviewed
R5492	T9030	T9000	punct	.,joins
R5493	T9032	T9033	nsubj	Comparison,provide
R5494	T9034	T9032	prep	with,Comparison
R5495	T9035	T9036	amod	other,phenotypes
R5496	T9036	T9034	pobj	phenotypes,with
R5497	T9037	T9033	aux	might,provide
R5498	T9038	T9039	det	some,insight
R5499	T9039	T9033	dobj	insight,provide
R5500	T9040	T9033	prep	into,provide
R5501	T9041	T9042	det	the,role
R5502	T9042	T9040	pobj	role,into
R5503	T9043	T9042	prep	of,role
R5504	T9044	T9043	pobj	Atrx,of
R5505	T9045	T9042	prep	in,role
R5506	T9046	T9047	compound	trophoblast,development
R5507	T9047	T9045	pobj	development,in
R5508	T9048	T9033	punct	.,provide
R5509	T9050	T9051	compound	Atrx,mutant
R5510	T9051	T9053	compound	mutant,embryos
R5511	T9052	T9051	punct	-,mutant
R5512	T9053	T9054	nsubj	embryos,progress
R5513	T9055	T9054	advmod	further,progress
R5514	T9056	T9055	prep	than,further
R5515	T9057	T9056	pobj	embryos,than
R5516	T9058	T9057	amod	nullizygous,embryos
R5517	T9059	T9058	prep	for,nullizygous
R5518	T9060	T9059	pobj	factors,for
R5519	T9061	T9060	acl	involved,factors
R5520	T9062	T9061	prep	in,involved
R5521	T9063	T9064	det	the,specification
R5522	T9064	T9062	pobj	specification,in
R5523	T9065	T9064	amod	initial,specification
R5524	T9066	T9064	prep	of,specification
R5525	T9067	T9068	compound	trophoblast,cells
R5526	T9068	T9066	pobj	cells,of
R5527	T9069	T9068	compound	stem,cells
R5528	T9070	T9071	punct	(,as
R5529	T9071	T9064	parataxis	as,specification
R5530	T9072	T9071	amod	such,as
R5531	T9073	T9071	pobj	Cdx2,as
R5532	T9074	T9071	punct	),as
R5533	T9075	T9062	cc	or,in
R5534	T9076	T9062	conj	in,in
R5535	T9077	T9078	compound	stem,maintenance
R5536	T9078	T9076	pobj	maintenance,in
R5537	T9079	T9078	compound	cell,maintenance
R5538	T9080	T9078	cc	and,maintenance
R5539	T9081	T9078	conj	proliferation,maintenance
R5540	T9082	T9083	punct	(,as
R5541	T9083	T9078	parataxis	as,maintenance
R5542	T9084	T9083	amod	such,as
R5543	T9085	T9083	pobj	Eomes,as
R5544	T9086	T9083	punct	),as
R5545	T9087	T9054	punct	.,progress
R5546	T9089	T9090	compound	Cdx2,mutant
R5547	T9090	T9092	compound	mutant,embryos
R5548	T9091	T9090	punct	-,mutant
R5549	T9092	T9093	nsubj	embryos,fail
R5550	T9094	T9095	aux	to,implant
R5551	T9095	T9093	xcomp	implant,fail
R5552	T9096	T9093	cc	and,fail
R5553	T9097	T9093	conj	die,fail
R5554	T9098	T9099	quantmod	between,3.5
R5555	T9099	T9100	nummod	3.5,dpc
R5556	T9100	T9097	dobj	dpc,die
R5557	T9101	T9099	cc	and,3.5
R5558	T9102	T9099	conj	5.5,3.5
R5559	T9103	T9104	punct	[,26
R5560	T9104	T9093	parataxis	26,fail
R5561	T9105	T9104	punct	],26
R5562	T9106	T9093	punct	", ",fail
R5563	T9107	T9108	mark	while,implant
R5564	T9108	T9093	advcl	implant,fail
R5565	T9109	T9110	compound	Eomes,mutant
R5566	T9110	T9112	compound	mutant,blastocysts
R5567	T9111	T9110	punct	-,mutant
R5568	T9112	T9108	nsubj	blastocysts,implant
R5569	T9113	T9108	prep	into,implant
R5570	T9114	T9115	det	the,uterus
R5571	T9115	T9113	pobj	uterus,into
R5572	T9116	T9108	punct	", ",implant
R5573	T9117	T9108	cc	but,implant
R5574	T9118	T9108	conj	arrest,implant
R5575	T9119	T9120	advmod	soon,after
R5576	T9120	T9118	prep	after,arrest
R5577	T9121	T9120	pobj	implantation,after
R5578	T9122	T9118	prep	without,arrest
R5579	T9123	T9122	pcomp	forming,without
R5580	T9124	T9125	amod	organised,structures
R5581	T9125	T9123	dobj	structures,forming
R5582	T9126	T9125	amod	embryonic,structures
R5583	T9127	T9126	cc	or,embryonic
R5584	T9128	T9126	conj	extraembryonic,embryonic
R5585	T9129	T9130	punct	[,27
R5586	T9130	T9093	parataxis	27,fail
R5587	T9131	T9130	punct	],27
R5588	T9132	T9093	punct	.,fail
R5589	T9134	T9135	prep	In,implant
R5590	T9136	T9134	pobj	contrast,In
R5591	T9137	T9135	punct	", ",implant
R5592	T9138	T9139	compound	Atrx,mutant
R5593	T9139	T9141	compound	mutant,embryos
R5594	T9140	T9139	punct	-,mutant
R5595	T9141	T9135	nsubj	embryos,implant
R5596	T9142	T9135	advmod	successfully,implant
R5597	T9143	T9135	cc	and,implant
R5598	T9144	T9135	conj	establish,implant
R5599	T9145	T9146	amod	organised,structures
R5600	T9146	T9144	dobj	structures,establish
R5601	T9147	T9146	amod	embryonic,structures
R5602	T9148	T9144	prep	by,establish
R5603	T9149	T9150	nummod	7.5,dpc
R5604	T9150	T9148	pobj	dpc,by
R5605	T9151	T9135	punct	.,implant
R5606	T9153	T9154	det	The,phenotype
R5607	T9154	T9158	nsubj	phenotype,resembles
R5608	T9155	T9156	compound	Atrx,mutant
R5609	T9156	T9154	compound	mutant,phenotype
R5610	T9157	T9156	punct	-,mutant
R5611	T9159	T9158	advmod	closely,resembles
R5612	T9160	T9158	dobj	that,resembles
R5613	T9161	T9160	acl	observed,that
R5614	T9162	T9161	prep	in,observed
R5615	T9163	T9162	pobj	mice,in
R5616	T9164	T9163	amod	nullizygous,mice
R5617	T9165	T9164	prep	for,nullizygous
R5618	T9166	T9167	det	the,factor
R5619	T9167	T9165	pobj	factor,for
R5620	T9168	T9167	amod	basic,factor
R5621	T9169	T9170	compound	helix,helix
R5622	T9170	T9167	compound	helix,factor
R5623	T9171	T9170	punct	-,helix
R5624	T9172	T9170	compound	loop,helix
R5625	T9173	T9170	punct	-,helix
R5626	T9174	T9167	compound	transcription,factor
R5627	T9175	T9167	appos	Hand1,factor
R5628	T9176	T9158	punct	.,resembles
R5629	T9178	T9179	compound	Hand1,mutant
R5630	T9179	T9181	compound	mutant,conceptuses
R5631	T9180	T9179	punct	-,mutant
R5632	T9181	T9182	nsubj	conceptuses,arrest
R5633	T9183	T9182	prep	at,arrest
R5634	T9184	T9185	quantmod	around,7.5
R5635	T9185	T9186	nummod	7.5,dpc
R5636	T9186	T9183	pobj	dpc,at
R5637	T9187	T9182	cc	and,arrest
R5638	T9188	T9182	conj	display,arrest
R5639	T9189	T9190	det	a,compartment
R5640	T9190	T9188	dobj	compartment,display
R5641	T9191	T9190	amod	normal,compartment
R5642	T9192	T9190	amod	embryonic,compartment
R5643	T9193	T9182	punct	", ",arrest
R5644	T9194	T9182	cc	but,arrest
R5645	T9195	T9182	punct	", ",arrest
R5646	T9196	T9197	prep	like,causes
R5647	T9197	T9182	conj	causes,arrest
R5648	T9198	T9199	compound	Atrx,mutant
R5649	T9199	T9201	compound	mutant,embryos
R5650	T9200	T9199	punct	-,mutant
R5651	T9201	T9196	pobj	embryos,like
R5652	T9202	T9197	punct	", ",causes
R5653	T9203	T9197	nsubj	ablation,causes
R5654	T9204	T9203	prep	of,ablation
R5655	T9205	T9204	pobj	Hand1,of
R5656	T9206	T9207	det	a,reduction
R5657	T9207	T9197	dobj	reduction,causes
R5658	T9208	T9207	prep	in,reduction
R5659	T9209	T9210	det	the,size
R5660	T9210	T9208	pobj	size,in
R5661	T9211	T9210	prep	of,size
R5662	T9212	T9213	det	the,cone
R5663	T9213	T9211	pobj	cone,of
R5664	T9214	T9213	amod	ectoplacental,cone
R5665	T9215	T9210	cc	and,size
R5666	T9216	T9210	conj	density,size
R5667	T9217	T9216	prep	of,density
R5668	T9218	T9217	pobj	TGCs,of
R5669	T9219	T9220	punct	[,28
R5670	T9220	T9197	parataxis	28,causes
R5671	T9221	T9220	punct	],28
R5672	T9222	T9197	punct	.,causes
R5673	T9224	T9225	prep	As,recovered
R5674	T9226	T9224	prep	with,As
R5675	T9227	T9228	compound	Atrx,mutants
R5676	T9228	T9226	pobj	mutants,with
R5677	T9229	T9225	punct	", ",recovered
R5678	T9230	T9231	advmod	only,conceptuses
R5679	T9231	T9225	nsubjpass	conceptuses,recovered
R5680	T9232	T9231	amod	arrested,conceptuses
R5681	T9233	T9232	cc	or,arrested
R5682	T9234	T9232	conj	resorbed,arrested
R5683	T9235	T9236	compound	Hand1,mutant
R5684	T9236	T9231	compound	mutant,conceptuses
R5685	T9237	T9236	punct	-,mutant
R5686	T9238	T9225	auxpass	were,recovered
R5687	T9239	T9225	prep	after,recovered
R5688	T9240	T9241	nummod	8.5,dpc
R5689	T9241	T9239	pobj	dpc,after
R5690	T9242	T9225	punct	.,recovered
R5691	T9244	T9245	advmod	Also,affects
R5692	T9246	T9245	prep	like,affects
R5693	T9247	T9246	pobj	Atrx,like
R5694	T9248	T9245	punct	", ",affects
R5695	T9249	T9245	nsubj	disruption,affects
R5696	T9250	T9249	prep	of,disruption
R5697	T9251	T9250	pobj	Hand1,of
R5698	T9252	T9245	advmod	specifically,affects
R5699	T9253	T9254	amod	secondary,cell
R5700	T9254	T9256	compound	cell,formation
R5701	T9255	T9254	amod	giant,cell
R5702	T9256	T9245	dobj	formation,affects
R5703	T9257	T9245	punct	", ",affects
R5704	T9258	T9245	cc	and,affects
R5705	T9259	T9260	amod	primary,outgrowths
R5706	T9260	T9262	nsubj	outgrowths,appeared
R5707	T9261	T9260	compound	trophoblast,outgrowths
R5708	T9262	T9245	conj	appeared,affects
R5709	T9263	T9260	prep	from,outgrowths
R5710	T9264	T9263	pobj	blastocysts,from
R5711	T9265	T9262	oprd	normal,appeared
R5712	T9266	T9262	punct	.,appeared
R5713	T9268	T9269	nsubjpass	Hand1,required
R5714	T9270	T9269	auxpass	is,required
R5715	T9271	T9269	prep	for,required
R5716	T9272	T9273	amod	terminal,differentiation
R5717	T9273	T9271	pobj	differentiation,for
R5718	T9274	T9273	prep	of,differentiation
R5719	T9275	T9276	amod	secondary,TGCs
R5720	T9276	T9274	pobj	TGCs,of
R5721	T9277	T9269	punct	", ",required
R5722	T9278	T9269	cc	and,required
R5723	T9279	T9280	prep	in,arrest
R5724	T9280	T9269	conj	arrest,required
R5725	T9281	T9282	poss	its,absence
R5726	T9282	T9279	pobj	absence,in
R5727	T9283	T9284	compound	trophoblast,cells
R5728	T9284	T9280	nsubj	cells,arrest
R5729	T9285	T9280	prep	at,arrest
R5730	T9286	T9287	det	a,stage
R5731	T9287	T9285	pobj	stage,at
R5732	T9288	T9287	compound	precursor,stage
R5733	T9289	T9280	prep	in,arrest
R5734	T9290	T9291	det	the,cone
R5735	T9291	T9289	pobj	cone,in
R5736	T9292	T9291	amod	ectoplacental,cone
R5737	T9293	T9294	punct	[,28
R5738	T9294	T9280	parataxis	28,arrest
R5739	T9295	T9294	nummod	17,28
R5740	T9296	T9294	punct	",",28
R5741	T9297	T9294	punct	],28
R5742	T9298	T9280	punct	.,arrest
R5743	T9300	T9301	prep	Given,be
R5744	T9302	T9303	det	the,similarity
R5745	T9303	T9300	pobj	similarity,Given
R5746	T9304	T9303	prep	of,similarity
R5747	T9305	T9306	det	the,phenotypes
R5748	T9306	T9304	pobj	phenotypes,of
R5749	T9307	T9308	nmod	Atrx,mutant
R5750	T9308	T9306	compound	mutant,phenotypes
R5751	T9309	T9307	punct	-,Atrx
R5752	T9310	T9307	cc	and,Atrx
R5753	T9311	T9307	conj	Hand1,Atrx
R5754	T9312	T9308	punct	-,mutant
R5755	T9313	T9303	cc	and,similarity
R5756	T9314	T9315	det	the,likelihood
R5757	T9315	T9303	conj	likelihood,similarity
R5758	T9316	T9317	mark	that,acts
R5759	T9317	T9315	acl	acts,likelihood
R5760	T9318	T9317	nsubj	Atrx,acts
R5761	T9319	T9317	prep	as,acts
R5762	T9320	T9321	det	a,regulator
R5763	T9321	T9319	pobj	regulator,as
R5764	T9322	T9321	amod	transcriptional,regulator
R5765	T9323	T9317	prep	by,acts
R5766	T9324	T9323	pcomp	modifying,by
R5767	T9325	T9326	compound	chromatin,structure
R5768	T9326	T9324	dobj	structure,modifying
R5769	T9327	T9301	punct	", ",be
R5770	T9328	T9301	nsubj	it,be
R5771	T9329	T9301	aux	will,be
R5772	T9330	T9301	prep	of,be
R5773	T9331	T9330	pobj	interest,of
R5774	T9332	T9333	aux	to,determine
R5775	T9333	T9301	xcomp	determine,be
R5776	T9334	T9335	mark	whether,is
R5777	T9335	T9333	advcl	is,determine
R5778	T9336	T9335	nsubj	Atrx,is
R5779	T9337	T9335	npadvmod	itself,is
R5780	T9338	T9339	det	a,regulator
R5781	T9339	T9335	attr	regulator,is
R5782	T9340	T9339	prep	of,regulator
R5783	T9341	T9342	compound	Hand1,expression
R5784	T9342	T9340	pobj	expression,of
R5785	T9343	T9335	punct	", ",is
R5786	T9344	T9335	cc	or,is
R5787	T9345	T9346	advmod	alternatively,acts
R5788	T9346	T9335	conj	acts,is
R5789	T9347	T9346	mark	whether,acts
R5790	T9348	T9346	nsubj	it,acts
R5791	T9349	T9346	prep	as,acts
R5792	T9350	T9351	det	a,co-regulator
R5793	T9351	T9349	pobj	co-regulator,as
R5794	T9352	T9351	prep	of,co-regulator
R5795	T9353	T9352	pobj	one,of
R5796	T9354	T9353	cc	or,one
R5797	T9355	T9353	conj	more,one
R5798	T9356	T9353	prep	of,one
R5799	T9357	T9358	det	the,targets
R5800	T9358	T9356	pobj	targets,of
R5801	T9359	T9358	amod	downstream,targets
R5802	T9360	T9358	amod	transcriptional,targets
R5803	T9361	T9358	prep	of,targets
R5804	T9362	T9361	pobj	Hand1,of
R5805	T9363	T9301	punct	.,be
R5806	T9365	T9366	nsubj	It,is
R5807	T9367	T9366	acomp	noteworthy,is
R5808	T9368	T9369	mark	that,observed
R5809	T9369	T9366	ccomp	observed,is
R5810	T9370	T9369	punct	", ",observed
R5811	T9371	T9369	prep	in,observed
R5812	T9372	T9373	det	the,mice
R5813	T9373	T9371	pobj	mice,in
R5814	T9374	T9375	npadvmod	brain,specific
R5815	T9375	T9373	amod	specific,mice
R5816	T9376	T9375	punct	-,specific
R5817	T9377	T9378	compound	Atrx,knockout
R5818	T9378	T9373	compound	knockout,mice
R5819	T9379	T9369	punct	", ",observed
R5820	T9380	T9381	det	the,defect
R5821	T9381	T9369	nsubjpass	defect,observed
R5822	T9382	T9369	auxpass	was,observed
R5823	T9383	T9369	prep	in,observed
R5824	T9384	T9385	advmod	terminally,differentiating
R5825	T9385	T9386	amod	differentiating,neurons
R5826	T9386	T9383	pobj	neurons,in
R5827	T9387	T9388	punct	[,20
R5828	T9388	T9366	parataxis	20,is
R5829	T9389	T9388	punct	],20
R5830	T9390	T9366	punct	.,is
R5831	T9392	T9393	det	The,TGCs
R5832	T9393	T9395	nsubj	TGCs,represent
R5833	T9394	T9393	amod	secondary,TGCs
R5834	T9396	T9393	acl	affected,TGCs
R5835	T9397	T9396	prep	in,affected
R5836	T9398	T9399	det	the,knockout
R5837	T9399	T9397	pobj	knockout,in
R5838	T9400	T9399	amod	universal,knockout
R5839	T9401	T9399	compound	Atrx,knockout
R5840	T9402	T9399	acl	reported,knockout
R5841	T9403	T9402	advmod	here,reported
R5842	T9404	T9395	dobj	one,represent
R5843	T9405	T9404	prep	of,one
R5844	T9406	T9407	det	the,tissues
R5845	T9407	T9405	pobj	tissues,of
R5846	T9408	T9407	amod	first,tissues
R5847	T9409	T9410	advmod	terminally,differentiated
R5848	T9410	T9407	amod	differentiated,tissues
R5849	T9411	T9404	prep	in,one
R5850	T9412	T9413	det	the,mouse
R5851	T9413	T9411	pobj	mouse,in
R5852	T9414	T9413	amod	developing,mouse
R5853	T9415	T9395	punct	", ",represent
R5854	T9416	T9395	cc	and,represent
R5855	T9417	T9418	nsubj	this,point
R5856	T9418	T9395	conj	point,represent
R5857	T9419	T9418	aux	may,point
R5858	T9420	T9418	prep	to,point
R5859	T9421	T9422	det	the,requirement
R5860	T9422	T9420	pobj	requirement,to
R5861	T9423	T9422	prep	for,requirement
R5862	T9424	T9423	pobj	Atrx,for
R5863	T9425	T9422	prep	in,requirement
R5864	T9426	T9427	det	the,expression
R5865	T9427	T9425	pobj	expression,in
R5866	T9428	T9429	amod	high,level
R5867	T9429	T9427	compound	level,expression
R5868	T9430	T9429	punct	-,level
R5869	T9431	T9427	prep	of,expression
R5870	T9432	T9433	det	some,genes
R5871	T9433	T9431	pobj	genes,of
R5872	T9434	T9435	npadvmod	tissue,specific
R5873	T9435	T9433	amod	specific,genes
R5874	T9436	T9435	punct	-,specific
R5875	T9437	T9422	prep	during,requirement
R5876	T9438	T9439	det	the,stages
R5877	T9439	T9437	pobj	stages,during
R5878	T9440	T9439	amod	final,stages
R5879	T9441	T9439	prep	of,stages
R5880	T9442	T9441	pobj	differentiation,of
R5881	T9443	T9418	punct	.,point
R5882	T9445	T9446	advmod	Interestingly,expressed
R5883	T9447	T9446	punct	", ",expressed
R5884	T9448	T9449	det	the,genes
R5885	T9449	T9446	nsubjpass	genes,expressed
R5886	T9450	T9451	compound	α,globin
R5887	T9451	T9449	compound	globin,genes
R5888	T9452	T9451	punct	-,globin
R5889	T9453	T9449	punct	", ",genes
R5890	T9454	T9455	det	the,targets
R5891	T9455	T9449	appos	targets,genes
R5892	T9456	T9455	advmod	only,targets
R5893	T9457	T9455	amod	confirmed,targets
R5894	T9458	T9455	amod	transcriptional,targets
R5895	T9459	T9455	prep	of,targets
R5896	T9460	T9459	pobj	regulation,of
R5897	T9461	T9460	prep	by,regulation
R5898	T9462	T9463	amod	human,ATRX
R5899	T9463	T9461	pobj	ATRX,by
R5900	T9464	T9446	punct	", ",expressed
R5901	T9465	T9446	auxpass	are,expressed
R5902	T9466	T9446	advmod	also,expressed
R5903	T9467	T9446	advmod	highly,expressed
R5904	T9468	T9469	advmod	specifically,during
R5905	T9469	T9446	prep	during,expressed
R5906	T9470	T9471	amod	terminal,differentiation
R5907	T9471	T9469	pobj	differentiation,during
R5908	T9472	T9446	prep	within,expressed
R5909	T9473	T9474	det	the,lineage
R5910	T9474	T9472	pobj	lineage,within
R5911	T9475	T9474	amod	erythroid,lineage
R5912	T9476	T9446	punct	.,expressed
R5927	T9932	T9933	nsubj	Atrx,Escapes
R5928	T9934	T9935	amod	Imprinted,Inactivation
R5929	T9935	T9933	dobj	Inactivation,Escapes
R5930	T9936	T9935	compound	X,Inactivation
R5931	T9937	T9935	punct	-,Inactivation
R5932	T9938	T9933	prep	in,Escapes
R5933	T9939	T9940	amod	Extraembryonic,Tissues
R5934	T9940	T9938	pobj	Tissues,in
R5935	T9941	T9940	prep	of,Tissues
R5936	T9942	T9943	nmod	Carrier,Mice
R5937	T9943	T9941	pobj	Mice,of
R5938	T9944	T9943	amod	Female,Mice
R5939	T9946	T9947	det	Another,finding
R5940	T9947	T9949	nsubj	finding,is
R5941	T9948	T9947	amod	surprising,finding
R5942	T9950	T9947	prep	of,finding
R5943	T9951	T9952	det	this,study
R5944	T9952	T9950	pobj	study,of
R5945	T9953	T9954	mark	that,appears
R5946	T9954	T9949	ccomp	appears,is
R5947	T9955	T9954	punct	", ",appears
R5948	T9956	T9954	prep	in,appears
R5949	T9957	T9958	nmod	carrier,embryos
R5950	T9958	T9956	pobj	embryos,in
R5951	T9959	T9958	amod	female,embryos
R5952	T9960	T9954	punct	", ",appears
R5953	T9961	T9962	det	a,allele
R5954	T9962	T9954	nsubj	allele,appears
R5955	T9963	T9964	advmod	paternally,inherited
R5956	T9964	T9962	amod	inherited,allele
R5957	T9965	T9962	compound	Atrx WT,allele
R5958	T9966	T9967	aux	to,escape
R5959	T9967	T9954	xcomp	escape,appears
R5960	T9968	T9969	det	the,process
R5961	T9969	T9967	dobj	process,escape
R5962	T9970	T9969	prep	of,process
R5963	T9971	T9972	amod	imprinted,inactivation
R5964	T9972	T9970	pobj	inactivation,of
R5965	T9973	T9972	compound	X,inactivation
R5966	T9974	T9972	punct	-,inactivation
R5967	T9975	T9969	punct	", ",process
R5968	T9976	T9977	dep	which,silences
R5969	T9977	T9969	relcl	silences,process
R5970	T9978	T9977	advmod	ordinarily,silences
R5971	T9979	T9980	det	the,chromosome
R5972	T9980	T9977	dobj	chromosome,silences
R5973	T9981	T9980	compound	Xp,chromosome
R5974	T9982	T9977	prep	in,silences
R5975	T9983	T9984	det	the,compartment
R5976	T9984	T9982	pobj	compartment,in
R5977	T9985	T9984	amod	extraembryonic,compartment
R5978	T9986	T9984	prep	of,compartment
R5979	T9987	T9988	amod	female,tissues
R5980	T9988	T9986	pobj	tissues,of
R5981	T9989	T9988	amod	murine,tissues
R5982	T9990	T9991	punct	[,18
R5983	T9991	T9949	parataxis	18,is
R5984	T9992	T9991	punct	],18
R5985	T9993	T9949	punct	.,is
R5986	T9995	T9996	nsubj	Silencing,render
R5987	T9997	T9995	prep	of,Silencing
R5988	T9998	T9999	det	the,allele
R5989	T9999	T9997	pobj	allele,of
R5990	T10000	T9999	compound	Atrx WT,allele
R5991	T10001	T9995	prep	on,Silencing
R5992	T10002	T10001	pobj	Xp,on
R5993	T10003	T9996	aux	should,render
R5994	T10004	T10005	det	these,females
R5995	T10005	T9996	dobj	females,render
R5996	T10006	T9996	oprd	null,render
R5997	T10007	T10006	prep	for,null
R5998	T10008	T10007	pobj	Atrx,for
R5999	T10009	T9996	prep	in,render
R6000	T10010	T10011	det	the,tissues
R6001	T10011	T10009	pobj	tissues,in
R6002	T10012	T10011	amod	extraembryonic,tissues
R6003	T10013	T9996	punct	", ",render
R6004	T10014	T10015	mark	since,carries
R6005	T10015	T9996	advcl	carries,render
R6006	T10016	T10017	det	the,chromosome
R6007	T10017	T10015	nsubj	chromosome,carries
R6008	T10018	T10019	advmod	normally,active
R6009	T10019	T10017	amod	active,chromosome
R6010	T10020	T10017	compound	Xm,chromosome
R6011	T10021	T10022	det	the,allele
R6012	T10022	T10015	dobj	allele,carries
R6013	T10023	T10022	compound	Atrx Δ18Δneo,allele
R6014	T10024	T9996	punct	.,render
R6015	T10026	T10027	mark	Although,normal
R6016	T10027	T10030	advcl	normal,developed
R6017	T10028	T10027	neg	not,normal
R6018	T10029	T10027	advmod	phenotypically,normal
R6019	T10031	T10030	punct	", ",developed
R6020	T10032	T10033	det	some,females
R6021	T10033	T10030	nsubj	females,developed
R6022	T10034	T10033	compound	Atrx,females
R6023	T10035	T10033	compound	carrier,females
R6024	T10036	T10030	prep	to,developed
R6025	T10037	T10036	pobj	term,to
R6026	T10038	T10030	cc	and,developed
R6027	T10039	T10030	conj	went,developed
R6028	T10040	T10039	prt	on,went
R6029	T10041	T10042	aux	to,reproduce
R6030	T10042	T10039	xcomp	reproduce,went
R6031	T10043	T10030	punct	.,developed
R6032	T10045	T10046	advmod	Thus,is
R6033	T10047	T10046	punct	", ",is
R6034	T10048	T10049	det	the,failure
R6035	T10049	T10046	nsubj	failure,is
R6036	T10050	T10051	aux	to,silence
R6037	T10051	T10049	acl	silence,failure
R6038	T10052	T10051	advmod	correctly,silence
R6039	T10053	T10054	det	the,allele
R6040	T10054	T10051	dobj	allele,silence
R6041	T10055	T10056	advmod	paternally,derived
R6042	T10056	T10054	amod	derived,allele
R6043	T10057	T10054	compound	Atrx WT,allele
R6044	T10058	T10054	prep	in,allele
R6045	T10059	T10060	det	the,tissues
R6046	T10060	T10058	pobj	tissues,in
R6047	T10061	T10060	amod	extraembryonic,tissues
R6048	T10062	T10060	prep	of,tissues
R6049	T10063	T10064	compound	carrier,females
R6050	T10064	T10062	pobj	females,of
R6051	T10065	T10046	acomp	consistent,is
R6052	T10066	T10065	prep	with,consistent
R6053	T10067	T10068	poss	our,observations
R6054	T10068	T10066	pobj	observations,with
R6055	T10069	T10070	mark	that,plays
R6056	T10070	T10068	acl	plays,observations
R6057	T10071	T10070	prep	in,plays
R6058	T10072	T10073	amod	Atrxnull,males
R6059	T10073	T10071	pobj	males,in
R6060	T10074	T10070	punct	", ",plays
R6061	T10075	T10076	det	the,protein
R6062	T10076	T10070	nsubj	protein,plays
R6063	T10077	T10076	compound	Atrx,protein
R6064	T10078	T10079	det	an,role
R6065	T10079	T10070	dobj	role,plays
R6066	T10080	T10079	amod	essential,role
R6067	T10081	T10070	prep	in,plays
R6068	T10082	T10083	det	the,development
R6069	T10083	T10081	pobj	development,in
R6070	T10084	T10083	prep	of,development
R6071	T10085	T10086	det	the,trophoblast
R6072	T10086	T10084	pobj	trophoblast,of
R6073	T10087	T10070	cc	and,plays
R6074	T10088	T10070	conj	is,plays
R6075	T10089	T10088	acomp	necessary,is
R6076	T10090	T10089	prep	for,necessary
R6077	T10091	T10090	pobj	survival,for
R6078	T10092	T10093	advmod	in,utero
R6079	T10093	T10091	advmod	utero,survival
R6080	T10094	T10088	prep	in,is
R6081	T10095	T10096	det	the,mouse
R6082	T10096	T10094	pobj	mouse,in
R6083	T10097	T10046	punct	.,is
R6084	T10099	T10100	det	The,survival
R6085	T10100	T10101	nsubj	survival,contrasts
R6086	T10102	T10100	prep	of,survival
R6087	T10103	T10104	compound	Atrx,females
R6088	T10104	T10102	pobj	females,of
R6089	T10105	T10104	compound	carrier,females
R6090	T10106	T10101	prep	with,contrasts
R6091	T10107	T10108	det	the,phenotypes
R6092	T10108	T10106	pobj	phenotypes,with
R6093	T10109	T10108	acl	seen,phenotypes
R6094	T10110	T10109	prep	in,seen
R6095	T10111	T10110	pobj	carriers,in
R6096	T10112	T10111	prep	of,carriers
R6097	T10113	T10112	pobj	mutations,of
R6098	T10114	T10113	prep	of,mutations
R6099	T10115	T10116	amod	other,genes
R6100	T10116	T10114	pobj	genes,of
R6101	T10117	T10116	amod	murine,genes
R6102	T10118	T10119	npadvmod	X,linked
R6103	T10119	T10116	amod	linked,genes
R6104	T10120	T10119	punct	-,linked
R6105	T10121	T10116	acl	known,genes
R6106	T10122	T10123	aux	to,be
R6107	T10123	T10121	xcomp	be,known
R6108	T10124	T10123	acomp	essential,be
R6109	T10125	T10123	prep	in,be
R6110	T10126	T10127	det	the,compartment
R6111	T10127	T10125	pobj	compartment,in
R6112	T10128	T10127	amod	extraembryonic,compartment
R6113	T10129	T10101	punct	.,contrasts
R6114	T10131	T10132	prep	For,cause
R6115	T10133	T10131	pobj	example,For
R6116	T10134	T10132	punct	", ",cause
R6117	T10135	T10136	amod	targeted,disruption
R6118	T10136	T10132	nsubj	disruption,cause
R6119	T10137	T10136	prep	of,disruption
R6120	T10138	T10139	det	the,genes
R6121	T10139	T10137	pobj	genes,of
R6122	T10140	T10139	nmod	dyskerin,genes
R6123	T10141	T10140	punct	(,dyskerin
R6124	T10142	T10140	appos	Dkc1,dyskerin
R6125	T10143	T10140	punct	),dyskerin
R6126	T10144	T10140	punct	", ",dyskerin
R6127	T10145	T10146	nmod	glucose,phosphate
R6128	T10146	T10149	compound	phosphate,dehydrogenase
R6129	T10147	T10146	nummod	6,phosphate
R6130	T10148	T10146	punct	-,phosphate
R6131	T10149	T10140	conj	dehydrogenase,dyskerin
R6132	T10150	T10149	punct	(,dehydrogenase
R6133	T10151	T10149	appos	G6PD,dehydrogenase
R6134	T10152	T10149	punct	),dehydrogenase
R6135	T10153	T10149	punct	", ",dehydrogenase
R6136	T10154	T10149	cc	and,dehydrogenase
R6137	T10155	T10149	conj	choroideremia,dehydrogenase
R6138	T10156	T10155	punct	(,choroideremia
R6139	T10157	T10155	appos	Chm,choroideremia
R6140	T10158	T10139	punct	),genes
R6141	T10159	T10160	amod	embryonic,lethality
R6142	T10160	T10132	dobj	lethality,cause
R6143	T10161	T10160	prep	in,lethality
R6144	T10162	T10163	amod	null,embryos
R6145	T10163	T10161	pobj	embryos,in
R6146	T10164	T10163	amod	male,embryos
R6147	T10165	T10132	prep	through,cause
R6148	T10166	T10165	pobj	defects,through
R6149	T10167	T10166	prep	of,defects
R6150	T10168	T10169	det	the,tissues
R6151	T10169	T10167	pobj	tissues,of
R6152	T10170	T10171	amod	extraembryonic,derived
R6153	T10171	T10169	amod	derived,tissues
R6154	T10172	T10171	punct	-,derived
R6155	T10173	T10174	punct	[,29
R6156	T10174	T10132	parataxis	29,cause
R6157	T10175	T10176	punct	–,31
R6158	T10176	T10174	prep	31,29
R6159	T10177	T10174	punct	],29
R6160	T10178	T10132	punct	.,cause
R6161	T10180	T10181	amod	Female,mice
R6162	T10181	T10182	nsubj	mice,die
R6163	T10183	T10181	acl	carrying,mice
R6164	T10184	T10183	dobj	mutations,carrying
R6165	T10185	T10184	prep	of,mutations
R6166	T10186	T10187	det	these,genes
R6167	T10187	T10185	pobj	genes,of
R6168	T10188	T10184	prep	on,mutations
R6169	T10189	T10190	det	the,chromosome
R6170	T10190	T10188	pobj	chromosome,on
R6171	T10191	T10192	advmod	maternally,inherited
R6172	T10192	T10190	amod	inherited,chromosome
R6173	T10193	T10190	compound	X,chromosome
R6174	T10194	T10182	advmod	also,die
R6175	T10195	T10196	advmod	in,utero
R6176	T10196	T10182	advmod	utero,die
R6177	T10197	T10182	punct	", ",die
R6178	T10198	T10199	mark	whereas,survive
R6179	T10199	T10182	advcl	survive,die
R6180	T10200	T10199	nsubj	females,survive
R6181	T10201	T10202	dep	that,inherit
R6182	T10202	T10200	relcl	inherit,females
R6183	T10203	T10204	det	the,mutation
R6184	T10204	T10202	dobj	mutation,inherit
R6185	T10205	T10204	prep	on,mutation
R6186	T10206	T10207	det	the,chromosome
R6187	T10207	T10205	pobj	chromosome,on
R6188	T10208	T10207	compound	Xp,chromosome
R6189	T10209	T10182	punct	.,die
R6190	T10211	T10212	advmod	Thus,are
R6191	T10213	T10212	punct	", ",are
R6192	T10214	T10212	prep	unlike,are
R6193	T10215	T10214	pobj	Atrx,unlike
R6194	T10216	T10212	punct	", ",are
R6195	T10217	T10218	det	these,genes
R6196	T10218	T10212	nsubj	genes,are
R6197	T10219	T10218	cc	and,genes
R6198	T10220	T10219	punct	/,and
R6199	T10221	T10219	cc	or,and
R6200	T10222	T10223	poss	their,effects
R6201	T10223	T10218	conj	effects,genes
R6202	T10224	T10223	prep	on,effects
R6203	T10225	T10226	compound	cell,growth
R6204	T10226	T10224	pobj	growth,on
R6205	T10227	T10212	acomp	unable,are
R6206	T10228	T10229	aux	to,circumvent
R6207	T10229	T10227	xcomp	circumvent,unable
R6208	T10230	T10231	det	the,processes
R6209	T10231	T10229	dobj	processes,circumvent
R6210	T10232	T10233	dep	that,cause
R6211	T10233	T10231	relcl	cause,processes
R6212	T10234	T10233	advmod	ultimately,cause
R6213	T10235	T10236	det	all,cells
R6214	T10236	T10237	nsubj	cells,express
R6215	T10237	T10233	ccomp	express,cause
R6216	T10238	T10236	prep	in,cells
R6217	T10239	T10240	det	the,tissues
R6218	T10240	T10238	pobj	tissues,in
R6219	T10241	T10240	amod	extraembryonic,tissues
R6220	T10242	T10237	aux	to,express
R6221	T10243	T10244	advmod	only,chromosome
R6222	T10244	T10237	dobj	chromosome,express
R6223	T10245	T10244	det	the,chromosome
R6224	T10246	T10247	advmod	maternally,derived
R6225	T10247	T10244	amod	derived,chromosome
R6226	T10248	T10244	compound	X,chromosome
R6227	T10249	T10212	punct	.,are
R6228	T10251	T10252	advmod	How,maintained
R6229	T10253	T10252	aux	might,maintained
R6230	T10254	T10252	nsubjpass	expression,maintained
R6231	T10255	T10254	prep	of,expression
R6232	T10256	T10257	det	the,allele
R6233	T10257	T10255	pobj	allele,of
R6234	T10258	T10259	amod	paternal,Atrx WT
R6235	T10259	T10257	compound	Atrx WT,allele
R6236	T10260	T10252	auxpass	be,maintained
R6237	T10261	T10252	prep	in,maintained
R6238	T10262	T10263	det	the,tissues
R6239	T10263	T10261	pobj	tissues,in
R6240	T10264	T10263	amod	extraembryonic,tissues
R6241	T10265	T10263	prep	of,tissues
R6242	T10266	T10267	det	the,females
R6243	T10267	T10265	pobj	females,of
R6244	T10268	T10269	compound	Atrx,carrier
R6245	T10269	T10267	compound	carrier,females
R6246	T10270	T10252	punct	?,maintained
R6247	T10272	T10273	nummod	One,possibility
R6248	T10273	T10274	nsubj	possibility,is
R6249	T10275	T10276	mark	that,is
R6250	T10276	T10274	ccomp	is,is
R6251	T10277	T10276	punct	", ",is
R6252	T10278	T10276	prep	like,is
R6253	T10279	T10280	det	some,genes
R6254	T10280	T10278	pobj	genes,like
R6255	T10281	T10280	amod	other,genes
R6256	T10282	T10283	npadvmod	X,linked
R6257	T10283	T10280	amod	linked,genes
R6258	T10284	T10283	punct	-,linked
R6259	T10285	T10276	punct	", ",is
R6260	T10286	T10276	nsubj	silencing,is
R6261	T10287	T10286	prep	of,silencing
R6262	T10288	T10289	det	the,gene
R6263	T10289	T10287	pobj	gene,of
R6264	T10290	T10289	compound	Atrx,gene
R6265	T10291	T10289	prep	on,gene
R6266	T10292	T10291	pobj	Xp,on
R6267	T10293	T10276	acomp	incomplete,is
R6268	T10294	T10276	punct	", ",is
R6269	T10295	T10296	amod	such,is
R6270	T10296	T10276	advcl	is,is
R6271	T10297	T10296	mark	that,is
R6272	T10298	T10296	expl	there,is
R6273	T10299	T10296	advmod	always,is
R6274	T10300	T10301	det	a,output
R6275	T10301	T10296	attr	output,is
R6276	T10302	T10303	amod	low,level
R6277	T10303	T10301	nmod	level,output
R6278	T10304	T10303	punct	-,level
R6279	T10305	T10301	punct	", ",output
R6280	T10306	T10301	amod	leaky,output
R6281	T10307	T10301	prep	of,output
R6282	T10308	T10307	pobj	Atrx,of
R6283	T10309	T10301	prep	from,output
R6284	T10310	T10311	det	a,chromosome
R6285	T10311	T10309	pobj	chromosome,from
R6286	T10312	T10313	advmod	normally,inactivated
R6287	T10313	T10311	amod	inactivated,chromosome
R6288	T10314	T10311	compound	Xp,chromosome
R6289	T10315	T10296	prep	in,is
R6290	T10316	T10317	amod	extraembryonic,tissues
R6291	T10317	T10315	pobj	tissues,in
R6292	T10318	T10274	punct	.,is
R6293	T10320	T10321	advmod	However,demonstrated
R6294	T10322	T10321	punct	", ",demonstrated
R6295	T10323	T10321	nsubjpass	it,demonstrated
R6296	T10324	T10321	auxpass	was,demonstrated
R6297	T10325	T10321	advmod	recently,demonstrated
R6298	T10326	T10327	mark	that,silenced
R6299	T10327	T10321	ccomp	silenced,demonstrated
R6300	T10328	T10329	det	the,allele
R6301	T10329	T10327	nsubjpass	allele,silenced
R6302	T10330	T10331	amod	paternal,Atrx
R6303	T10331	T10329	nmod	Atrx,allele
R6304	T10332	T10331	punct	(,Atrx
R6305	T10333	T10331	acl	called,Atrx
R6306	T10334	T10333	oprd	Xnp,called
R6307	T10335	T10329	punct	),allele
R6308	T10336	T10327	auxpass	is,silenced
R6309	T10337	T10327	advmod	completely,silenced
R6310	T10338	T10327	prep	in,silenced
R6311	T10339	T10340	det	a,line
R6312	T10340	T10338	pobj	line,in
R6313	T10341	T10340	amod	normal,line
R6314	T10342	T10343	compound	mouse,trophoblast
R6315	T10343	T10340	compound	trophoblast,line
R6316	T10344	T10345	compound	stem,cell
R6317	T10345	T10340	compound	cell,line
R6318	T10346	T10347	punct	[,32
R6319	T10347	T10321	parataxis	32,demonstrated
R6320	T10348	T10347	punct	],32
R6321	T10349	T10321	punct	", ",demonstrated
R6322	T10350	T10321	advcl	suggesting,demonstrated
R6323	T10351	T10352	mark	that,escape
R6324	T10352	T10350	ccomp	escape,suggesting
R6325	T10353	T10352	nsubj	Atrx,escape
R6326	T10354	T10352	aux	does,escape
R6327	T10355	T10352	neg	not,escape
R6328	T10356	T10352	advmod	normally,escape
R6329	T10357	T10358	amod	imprinted,inactivation
R6330	T10358	T10352	dobj	inactivation,escape
R6331	T10359	T10358	compound	X,inactivation
R6332	T10360	T10358	punct	-,inactivation
R6333	T10361	T10358	prep	in,inactivation
R6334	T10362	T10363	det	the,tissues
R6335	T10363	T10361	pobj	tissues,in
R6336	T10364	T10363	amod	extraembryonic,tissues
R6337	T10365	T10363	prep	of,tissues
R6338	T10366	T10367	amod	wild,type
R6339	T10367	T10369	compound	type,females
R6340	T10368	T10367	punct	-,type
R6341	T10369	T10365	pobj	females,of
R6342	T10370	T10321	punct	.,demonstrated
R6343	T10372	T10373	advmod	Thus,is
R6344	T10374	T10373	punct	", ",is
R6345	T10375	T10376	det	the,expression
R6346	T10376	T10373	nsubj	expression,is
R6347	T10377	T10376	prep	of,expression
R6348	T10378	T10379	det	the,allele
R6349	T10379	T10377	pobj	allele,of
R6350	T10380	T10381	npadvmod	Xp,linked
R6351	T10381	T10379	amod	linked,allele
R6352	T10382	T10381	punct	-,linked
R6353	T10383	T10379	compound	Atrx WT,allele
R6354	T10384	T10385	dep	that,observed
R6355	T10385	T10379	relcl	observed,allele
R6356	T10386	T10385	nsubj	we,observed
R6357	T10387	T10373	acomp	unique,is
R6358	T10388	T10387	prep	to,unique
R6359	T10389	T10390	amod	female,carriers
R6360	T10390	T10388	pobj	carriers,to
R6361	T10391	T10390	prep	of,carriers
R6362	T10392	T10393	det	the,allele
R6363	T10393	T10391	pobj	allele,of
R6364	T10394	T10393	amod	Atrx null,allele
R6365	T10395	T10373	punct	.,is
R6366	T10397	T10398	advmod	Perhaps,stems
R6367	T10399	T10400	det	a,explanation
R6368	T10400	T10398	nsubj	explanation,stems
R6369	T10401	T10402	advmod	more,likely
R6370	T10402	T10400	amod	likely,explanation
R6371	T10403	T10400	prep	for,explanation
R6372	T10404	T10405	det	this,phenomenon
R6373	T10405	T10403	pobj	phenomenon,for
R6374	T10406	T10398	prep	from,stems
R6375	T10407	T10408	amod	experimental,observations
R6376	T10408	T10406	pobj	observations,from
R6377	T10409	T10408	acl	suggesting,observations
R6378	T10410	T10411	mark	that,escape
R6379	T10411	T10409	ccomp	escape,suggesting
R6380	T10412	T10413	amod	imprinted,inactivation
R6381	T10413	T10416	nsubjpass	inactivation,imposed
R6382	T10414	T10413	compound	X,inactivation
R6383	T10415	T10413	punct	-,inactivation
R6384	T10416	T10411	ccomp	imposed,escape
R6385	T10417	T10416	auxpass	is,imposed
R6386	T10418	T10416	neg	not,imposed
R6387	T10419	T10416	prep	on,imposed
R6388	T10420	T10421	det	all,precursors
R6389	T10421	T10419	pobj	precursors,on
R6390	T10422	T10421	prep	of,precursors
R6391	T10423	T10424	det	the,tissues
R6392	T10424	T10422	pobj	tissues,of
R6393	T10425	T10424	nmod	mouse,tissues
R6394	T10426	T10425	amod	extraembryonic,mouse
R6395	T10427	T10411	punct	: ,escape
R6396	T10428	T10429	det	A,subpopulation
R6397	T10429	T10411	nsubj	subpopulation,escape
R6398	T10430	T10429	prep	of,subpopulation
R6399	T10431	T10430	pobj	cells,of
R6400	T10432	T10411	aux	may,escape
R6401	T10433	T10434	det	this,process
R6402	T10434	T10411	dobj	process,escape
R6403	T10435	T10411	cc	and,escape
R6404	T10436	T10411	conj	make,escape
R6405	T10437	T10438	det	a,choice
R6406	T10438	T10436	dobj	choice,make
R6407	T10439	T10438	amod	random,choice
R6408	T10440	T10438	punct	“,choice
R6409	T10441	T10438	punct	”,choice
R6410	T10442	T10438	prep	of,choice
R6411	T10443	T10444	det	which,chromosome
R6412	T10444	T10446	dep	chromosome,inactivated
R6413	T10445	T10444	compound	X,chromosome
R6414	T10446	T10442	pcomp	inactivated,of
R6415	T10447	T10446	aux	will,inactivated
R6416	T10448	T10446	auxpass	be,inactivated
R6417	T10449	T10398	punct	.,stems
R6418	T10451	T10452	prep	On,expected
R6419	T10453	T10451	amod	average,On
R6420	T10454	T10452	punct	", ",expected
R6421	T10455	T10456	nummod	50,%
R6422	T10456	T10452	nsubjpass	%,expected
R6423	T10457	T10456	prep	of,%
R6424	T10458	T10459	det	the,cells
R6425	T10459	T10457	pobj	cells,of
R6426	T10460	T10456	prep	in,%
R6427	T10461	T10462	det	this,subpopulation
R6428	T10462	T10460	pobj	subpopulation,in
R6429	T10463	T10464	advmod	randomly,inactivating
R6430	T10464	T10462	amod	inactivating,subpopulation
R6431	T10465	T10452	aux	would,expected
R6432	T10466	T10452	auxpass	be,expected
R6433	T10467	T10468	aux	to,maintain
R6434	T10468	T10452	xcomp	maintain,expected
R6435	T10469	T10470	det	an,chromosome
R6436	T10470	T10468	dobj	chromosome,maintain
R6437	T10471	T10470	amod	active,chromosome
R6438	T10472	T10470	compound	Xp,chromosome
R6439	T10473	T10452	punct	.,expected
R6440	T10475	T10476	prep	In,demonstrated
R6441	T10477	T10475	pobj	support,In
R6442	T10478	T10477	prep	of,support
R6443	T10479	T10480	det	this,hypothesis
R6444	T10480	T10478	pobj	hypothesis,of
R6445	T10481	T10476	punct	", ",demonstrated
R6446	T10482	T10476	nsubjpass	it,demonstrated
R6447	T10483	T10476	aux	has,demonstrated
R6448	T10484	T10476	auxpass	been,demonstrated
R6449	T10485	T10486	mark	that,failed
R6450	T10486	T10476	ccomp	failed,demonstrated
R6451	T10487	T10486	nsubj	expression,failed
R6452	T10488	T10487	prep	of,expression
R6453	T10489	T10490	advmod	paternally,transmitted
R6454	T10490	T10491	amod	transmitted,lacZ
R6455	T10491	T10495	nmod	lacZ,transgenes
R6456	T10492	T10493	npadvmod	X,linked
R6457	T10493	T10491	amod	linked,lacZ
R6458	T10494	T10493	punct	-,linked
R6459	T10495	T10488	pobj	transgenes,of
R6460	T10496	T10497	punct	[,34
R6461	T10497	T10491	parataxis	34,lacZ
R6462	T10498	T10497	nummod	33,34
R6463	T10499	T10497	punct	",",34
R6464	T10500	T10497	punct	],34
R6465	T10501	T10491	cc	and,lacZ
R6466	T10502	T10491	conj	GFP,lacZ
R6467	T10503	T10504	punct	[,35
R6468	T10504	T10502	parataxis	35,GFP
R6469	T10505	T10504	punct	],35
R6470	T10506	T10507	aux	to,silenced
R6471	T10507	T10486	xcomp	silenced,failed
R6472	T10508	T10507	auxpass	be,silenced
R6473	T10509	T10507	prep	in,silenced
R6474	T10510	T10511	det	a,subpopulation
R6475	T10511	T10509	pobj	subpopulation,in
R6476	T10512	T10511	amod	small,subpopulation
R6477	T10513	T10511	prep	of,subpopulation
R6478	T10514	T10515	amod	extraembryonic,cells
R6479	T10515	T10513	pobj	cells,of
R6480	T10516	T10476	punct	.,demonstrated
R6481	T10518	T10519	advmod	Further,shown
R6482	T10520	T10519	punct	", ",shown
R6483	T10521	T10519	nsubjpass	it,shown
R6484	T10522	T10519	aux	has,shown
R6485	T10523	T10519	auxpass	been,shown
R6486	T10524	T10525	mark	that,is
R6487	T10525	T10519	ccomp	is,shown
R6488	T10526	T10525	prep	in,is
R6489	T10527	T10528	det	a,subpopulation
R6490	T10528	T10526	pobj	subpopulation,in
R6491	T10529	T10528	prep	of,subpopulation
R6492	T10530	T10531	amod	extraembryonic,cells
R6493	T10531	T10529	pobj	cells,of
R6494	T10532	T10525	punct	", ",is
R6495	T10533	T10525	nsubj	it,is
R6496	T10534	T10535	det	the,Xm
R6497	T10535	T10525	attr	Xm,is
R6498	T10536	T10537	amod	rather,than
R6499	T10537	T10535	cc	than,Xm
R6500	T10538	T10539	det	the,Xp
R6501	T10539	T10535	conj	Xp,Xm
R6502	T10540	T10541	dep	that,undergoes
R6503	T10541	T10535	relcl	undergoes,Xm
R6504	T10542	T10543	amod	late,replication
R6505	T10543	T10541	dobj	replication,undergoes
R6506	T10544	T10543	punct	", ",replication
R6507	T10545	T10546	det	a,correlate
R6508	T10546	T10543	appos	correlate,replication
R6509	T10547	T10546	amod	molecular,correlate
R6510	T10548	T10546	prep	of,correlate
R6511	T10549	T10550	det	the,state
R6512	T10550	T10548	pobj	state,of
R6513	T10551	T10550	amod	inactive,state
R6514	T10552	T10553	punct	[,36
R6515	T10553	T10525	parataxis	36,is
R6516	T10554	T10553	nummod	18,36
R6517	T10555	T10553	punct	",",36
R6518	T10556	T10553	punct	],36
R6519	T10557	T10519	punct	.,shown
R6520	T10559	T10560	mark	Although,small
R6521	T10560	T10562	advcl	small,expand
R6522	T10561	T10560	advmod	initially,small
R6523	T10563	T10560	cc	and,small
R6524	T10564	T10565	advmod	quickly,diluted
R6525	T10565	T10560	conj	diluted,small
R6526	T10566	T10565	prep	in,diluted
R6527	T10567	T10568	amod	normal,embryos
R6528	T10568	T10566	pobj	embryos,in
R6529	T10569	T10562	punct	", ",expand
R6530	T10570	T10571	det	the,subpopulation
R6531	T10571	T10562	nsubj	subpopulation,expand
R6532	T10572	T10571	amod	cellular,subpopulation
R6533	T10573	T10574	dep	that,inactivates
R6534	T10574	T10571	relcl	inactivates,subpopulation
R6535	T10575	T10576	det	the,chromosome
R6536	T10576	T10574	dobj	chromosome,inactivates
R6537	T10577	T10576	compound	Xm,chromosome
R6538	T10578	T10562	aux	could,expand
R6539	T10579	T10562	advmod	rapidly,expand
R6540	T10580	T10581	aux	to,replace
R6541	T10581	T10562	advcl	replace,expand
R6542	T10582	T10583	det	the,cells
R6543	T10583	T10581	dobj	cells,replace
R6544	T10584	T10585	advmod	normally,imprinted
R6545	T10585	T10583	amod	imprinted,cells
R6546	T10586	T10583	prep	in,cells
R6547	T10587	T10588	amod	extraembryonic,lineages
R6548	T10588	T10586	pobj	lineages,in
R6549	T10589	T10590	mark	if,compromises
R6550	T10590	T10562	advcl	compromises,expand
R6551	T10591	T10592	det	the,silencing
R6552	T10592	T10590	nsubj	silencing,compromises
R6553	T10593	T10592	amod	normal,silencing
R6554	T10594	T10592	prep	of,silencing
R6555	T10595	T10594	pobj	Xp,of
R6556	T10596	T10597	compound	cell,growth
R6557	T10597	T10590	dobj	growth,compromises
R6558	T10598	T10597	cc	or,growth
R6559	T10599	T10597	conj	differentiation,growth
R6560	T10600	T10562	punct	.,expand
R6561	T10602	T10603	advmod	Interestingly,suggested
R6562	T10604	T10603	punct	", ",suggested
R6563	T10605	T10603	nsubjpass	it,suggested
R6564	T10606	T10603	aux	has,suggested
R6565	T10607	T10603	auxpass	been,suggested
R6566	T10608	T10609	mark	that,range
R6567	T10609	T10603	ccomp	range,suggested
R6568	T10610	T10611	det	the,size
R6569	T10611	T10609	nsubj	size,range
R6570	T10612	T10611	prep	of,size
R6571	T10613	T10614	det	the,population
R6572	T10614	T10612	pobj	population,of
R6573	T10615	T10616	dep	that,escapes
R6574	T10616	T10614	relcl	escapes,population
R6575	T10617	T10616	advmod	initially,escapes
R6576	T10618	T10616	dobj	imprinting,escapes
R6577	T10619	T10609	aux	may,range
R6578	T10620	T10609	advmod	widely,range
R6579	T10621	T10609	punct	(,range
R6580	T10622	T10609	prep	from,range
R6581	T10623	T10624	nummod	0,%
R6582	T10624	T10622	pobj	%,from
R6583	T10625	T10622	prep	to,from
R6584	T10626	T10627	nummod	30,%
R6585	T10627	T10625	pobj	%,to
R6586	T10628	T10609	punct	),range
R6587	T10629	T10609	punct	", ",range
R6588	T10630	T10631	advmod	even,between
R6589	T10631	T10609	prep	between,range
R6590	T10632	T10633	advmod	genetically,identical
R6591	T10633	T10634	amod	identical,embryos
R6592	T10634	T10631	pobj	embryos,between
R6593	T10635	T10636	punct	[,37
R6594	T10636	T10609	parataxis	37,range
R6595	T10637	T10636	punct	],37
R6596	T10638	T10603	punct	", ",suggested
R6597	T10639	T10603	cc	and,suggested
R6598	T10640	T10641	nsubj	this,account
R6599	T10641	T10603	conj	account,suggested
R6600	T10642	T10641	aux	may,account
R6601	T10643	T10641	prep	for,account
R6602	T10644	T10645	det	the,phenotype
R6603	T10645	T10643	pobj	phenotype,for
R6604	T10646	T10645	amod	variable,phenotype
R6605	T10647	T10645	acl	observed,phenotype
R6606	T10648	T10647	prep	among,observed
R6607	T10649	T10648	pobj	females,among
R6608	T10650	T10649	acl	bearing,females
R6609	T10651	T10652	npadvmod	Xm,linked
R6610	T10652	T10654	amod	linked,alleles
R6611	T10653	T10652	punct	-,linked
R6612	T10654	T10650	dobj	alleles,bearing
R6613	T10655	T10654	compound	mutant,alleles
R6614	T10656	T10654	prep	of,alleles
R6615	T10657	T10656	pobj	genes,of
R6616	T10658	T10657	amod	essential,genes
R6617	T10659	T10658	prep	for,essential
R6618	T10660	T10661	amod	normal,development
R6619	T10661	T10659	pobj	development,for
R6620	T10662	T10661	amod	extraembryonic,development
R6621	T10663	T10664	punct	[,38
R6622	T10664	T10641	parataxis	38,account
R6623	T10665	T10664	punct	],38
R6624	T10666	T10641	punct	.,account
R6625	T10668	T10669	advcl	Put,be
R6626	T10670	T10668	advmod	simply,Put
R6627	T10671	T10669	punct	", ",be
R6628	T10672	T10673	compound	carrier,females
R6629	T10673	T10669	nsubj	females,be
R6630	T10674	T10673	acl	bearing,females
R6631	T10675	T10676	det	a,population
R6632	T10676	T10674	dobj	population,bearing
R6633	T10677	T10676	amod	small,population
R6634	T10678	T10676	amod	initial,population
R6635	T10679	T10676	prep	of,population
R6636	T10680	T10681	amod	escaping,cells
R6637	T10681	T10679	pobj	cells,of
R6638	T10682	T10669	aux	would,be
R6639	T10683	T10684	advmod	more,severely
R6640	T10684	T10685	advmod	severely,affected
R6641	T10685	T10669	acomp	affected,be
R6642	T10686	T10685	prep	than,affected
R6643	T10687	T10686	pobj	those,than
R6644	T10688	T10687	acl	bearing,those
R6645	T10689	T10690	det	a,population
R6646	T10690	T10688	dobj	population,bearing
R6647	T10691	T10690	amod	larger,population
R6648	T10692	T10669	punct	.,be
R6649	T10694	T10695	nsubj	This,explain
R6650	T10696	T10695	aux	could,explain
R6651	T10697	T10698	advmod	why,observed
R6652	T10698	T10695	ccomp	observed,explain
R6653	T10699	T10698	nsubj	we,observed
R6654	T10700	T10698	aux	have,observed
R6655	T10701	T10702	amod	significant,variation
R6656	T10702	T10698	dobj	variation,observed
R6657	T10703	T10702	amod	phenotypic,variation
R6658	T10704	T10702	prep	among,variation
R6659	T10705	T10706	compound	Atrx,carrier
R6660	T10706	T10707	compound	carrier,females
R6661	T10707	T10704	pobj	females,among
R6662	T10708	T10698	punct	", ",observed
R6663	T10709	T10698	prep	with,observed
R6664	T10710	T10711	det	some,carriers
R6665	T10711	T10712	nsubj	carriers,dying
R6666	T10712	T10709	pobj	dying,with
R6667	T10713	T10714	advmod	in,utero
R6668	T10714	T10712	advmod	utero,dying
R6669	T10715	T10712	prep	by,dying
R6670	T10716	T10717	nummod	9.5,dpc
R6671	T10717	T10715	pobj	dpc,by
R6672	T10718	T10719	punct	(,Table
R6673	T10719	T10712	parataxis	Table,dying
R6674	T10720	T10719	nummod	1,Table
R6675	T10721	T10719	punct	),Table
R6676	T10722	T10712	cc	and,dying
R6677	T10723	T10724	nsubj	others,developing
R6678	T10724	T10712	conj	developing,dying
R6679	T10725	T10724	prep	to,developing
R6680	T10726	T10725	pobj	term,to
R6681	T10727	T10695	punct	.,explain
R6682	T10729	T10730	det	Another,mechanism
R6683	T10730	T10732	nsubj	mechanism,is
R6684	T10731	T10730	amod	possible,mechanism
R6685	T10733	T10734	mark	that,proceeds
R6686	T10734	T10732	ccomp	proceeds,is
R6687	T10735	T10734	nsubj	inactivation,proceeds
R6688	T10736	T10735	prep	of,inactivation
R6689	T10737	T10738	det	the,X
R6690	T10738	T10736	pobj	X,of
R6691	T10739	T10738	amod	paternal,X
R6692	T10740	T10734	advmod	normally,proceeds
R6693	T10741	T10734	prep	in,proceeds
R6694	T10742	T10743	det	all,cells
R6695	T10743	T10741	pobj	cells,in
R6696	T10744	T10734	punct	", ",proceeds
R6697	T10745	T10734	cc	but,proceeds
R6698	T10746	T10747	advmod	subsequently,reactivated
R6699	T10747	T10734	conj	reactivated,proceeds
R6700	T10748	T10749	det	the,gene
R6701	T10749	T10747	nsubjpass	gene,reactivated
R6702	T10750	T10749	compound	Atrx,gene
R6703	T10751	T10749	prep	within,gene
R6704	T10752	T10753	amod	individual,cells
R6705	T10753	T10751	pobj	cells,within
R6706	T10754	T10747	auxpass	is,reactivated
R6707	T10755	T10732	punct	.,is
R6708	T10757	T10758	advmod	Alternatively,escape
R6709	T10759	T10758	punct	", ",escape
R6710	T10760	T10758	prep	in,escape
R6711	T10761	T10762	det	the,absence
R6712	T10762	T10760	pobj	absence,in
R6713	T10763	T10762	prep	of,absence
R6714	T10764	T10763	pobj	Atrx,of
R6715	T10765	T10758	punct	", ",escape
R6716	T10766	T10767	det	the,allele
R6717	T10767	T10758	nsubj	allele,escape
R6718	T10768	T10767	amod	paternal,allele
R6719	T10769	T10758	aux	may,escape
R6720	T10770	T10758	advmod	partially,escape
R6721	T10771	T10772	det	the,process
R6722	T10772	T10758	dobj	process,escape
R6723	T10773	T10772	amod	normal,process
R6724	T10774	T10772	prep	of,process
R6725	T10775	T10774	pobj	silencing,of
R6726	T10776	T10758	punct	.,escape
R6727	T10778	T10779	prep	In,inactivated
R6728	T10780	T10778	pobj	both,In
R6729	T10781	T10780	prep	of,both
R6730	T10782	T10783	det	these,cases
R6731	T10783	T10781	pobj	cases,of
R6732	T10784	T10779	punct	", ",inactivated
R6733	T10785	T10786	amod	other,genes
R6734	T10786	T10779	nsubjpass	genes,inactivated
R6735	T10787	T10786	prep	on,genes
R6736	T10788	T10789	det	the,chromosome
R6737	T10789	T10787	pobj	chromosome,on
R6738	T10790	T10789	amod	paternal,chromosome
R6739	T10791	T10789	compound	X,chromosome
R6740	T10792	T10779	aux	must,inactivated
R6741	T10793	T10779	auxpass	be,inactivated
R6742	T10794	T10779	cc	and,inactivated
R6743	T10795	T10779	conj	remain,inactivated
R6744	T10796	T10795	advmod	so,remain
R6745	T10797	T10779	punct	", ",inactivated
R6746	T10798	T10799	mark	since,causes
R6747	T10799	T10779	advcl	causes,inactivated
R6748	T10800	T10801	amod	blocking,inactivation
R6749	T10801	T10799	nsubj	inactivation,causes
R6750	T10802	T10801	prep	of,inactivation
R6751	T10803	T10804	det	the,chromosome
R6752	T10804	T10802	pobj	chromosome,of
R6753	T10805	T10804	amod	entire,chromosome
R6754	T10806	T10804	compound	Xp,chromosome
R6755	T10807	T10808	amod	embryonic,lethality
R6756	T10808	T10799	dobj	lethality,causes
R6757	T10809	T10799	prep	due,causes
R6758	T10810	T10809	pcomp	to,due
R6759	T10811	T10812	amod	biallelic,expression
R6760	T10812	T10809	pobj	expression,due
R6761	T10813	T10812	prep	of,expression
R6762	T10814	T10815	npadvmod	X,linked
R6763	T10815	T10817	amod	linked,genes
R6764	T10816	T10815	punct	-,linked
R6765	T10817	T10813	pobj	genes,of
R6766	T10818	T10812	prep	in,expression
R6767	T10819	T10820	det	the,trophoblast
R6768	T10820	T10818	pobj	trophoblast,in
R6769	T10821	T10822	punct	[,39
R6770	T10822	T10779	parataxis	39,inactivated
R6771	T10823	T10822	punct	],39
R6772	T10824	T10779	punct	.,inactivated
R6773	T10927	T10928	compound	ATR,X
R6774	T10928	T10930	compound	X,syndrome
R6775	T10929	T10928	punct	-,X
R6776	T10930	T10931	nsubj	syndrome,is
R6777	T10932	T10933	det	the,disease
R6778	T10933	T10931	attr	disease,is
R6779	T10934	T10933	amod	first,disease
R6780	T10935	T10933	amod	human,disease
R6781	T10936	T10933	amod	genetic,disease
R6782	T10937	T10933	acl	known,disease
R6783	T10938	T10939	aux	to,caused
R6784	T10939	T10937	xcomp	caused,known
R6785	T10940	T10939	auxpass	be,caused
R6786	T10941	T10939	agent	by,caused
R6787	T10942	T10941	pobj	mutations,by
R6788	T10943	T10942	prep	in,mutations
R6789	T10944	T10945	det	a,factor
R6790	T10945	T10943	pobj	factor,in
R6791	T10946	T10947	compound	chromatin,remodelling
R6792	T10947	T10945	compound	remodelling,factor
R6793	T10948	T10931	punct	.,is
R6794	T10950	T10951	prep	At,know
R6795	T10952	T10950	amod	present,At
R6796	T10953	T10951	nsubj	we,know
R6797	T10954	T10951	aux	do,know
R6798	T10955	T10951	neg	not,know
R6799	T10956	T10957	advmod	how,influences
R6800	T10957	T10951	advcl	influences,know
R6801	T10958	T10957	nsubj	ATRX,influences
R6802	T10959	T10960	compound	gene,expression
R6803	T10960	T10957	dobj	expression,influences
R6804	T10961	T10957	cc	or,influences
R6805	T10962	T10963	det	what,effect
R6806	T10963	T10964	dep	effect,has
R6807	T10964	T10957	conj	has,influences
R6808	T10965	T10964	nsubj	it,has
R6809	T10966	T10964	prep	on,has
R6810	T10967	T10968	compound	cell,behaviour
R6811	T10968	T10966	pobj	behaviour,on
R6812	T10969	T10951	punct	.,know
R6813	T10971	T10972	advmod	Nevertheless,noted
R6814	T10973	T10972	punct	", ",noted
R6815	T10974	T10972	nsubj	we,noted
R6816	T10975	T10972	aux	have,noted
R6817	T10976	T10972	advmod	previously,noted
R6818	T10977	T10978	mark	that,are
R6819	T10978	T10972	ccomp	are,noted
R6820	T10979	T10978	nsubj	none,are
R6821	T10980	T10979	prep	of,none
R6822	T10981	T10982	det	the,mutations
R6823	T10982	T10980	pobj	mutations,of
R6824	T10983	T10982	amod	natural,mutations
R6825	T10984	T10982	acl	causing,mutations
R6826	T10985	T10986	compound	ATR,X
R6827	T10986	T10988	compound	X,syndrome
R6828	T10987	T10986	punct	-,X
R6829	T10988	T10984	dobj	syndrome,causing
R6830	T10989	T10978	attr	nulls,are
R6831	T10990	T10972	punct	", ",noted
R6832	T10991	T10992	dep	which,suggests
R6833	T10992	T10972	advcl	suggests,noted
R6834	T10993	T10994	mark	that,plays
R6835	T10994	T10992	ccomp	plays,suggests
R6836	T10995	T10994	nsubj	it,plays
R6837	T10996	T10997	det	a,role
R6838	T10997	T10994	dobj	role,plays
R6839	T10998	T10997	amod	critical,role
R6840	T10999	T10994	prep	in,plays
R6841	T11000	T11001	amod	normal,development
R6842	T11001	T10999	pobj	development,in
R6843	T11002	T10972	punct	.,noted
R6844	T11004	T11005	nsubj	Results,shows
R6845	T11006	T11004	prep	of,Results
R6846	T11007	T11008	amod	conditional,inactivation
R6847	T11008	T11006	pobj	inactivation,of
R6848	T11009	T11008	prep	of,inactivation
R6849	T11010	T11009	pobj	Atrx,of
R6850	T11011	T11008	prep	in,inactivation
R6851	T11012	T11013	det	the,forebrain
R6852	T11013	T11011	pobj	forebrain,in
R6853	T11014	T11013	amod	developing,forebrain
R6854	T11015	T11013	compound	mouse,forebrain
R6855	T11016	T11004	punct	", ",Results
R6856	T11017	T11004	prep	based,Results
R6857	T11018	T11017	prep	on,based
R6858	T11019	T11020	det	the,allele
R6859	T11020	T11018	pobj	allele,on
R6860	T11021	T11020	compound	Atrx flox,allele
R6861	T11022	T11020	acl	described,allele
R6862	T11023	T11022	advmod	here,described
R6863	T11024	T11005	punct	", ",shows
R6864	T11025	T11026	mark	that,exerts
R6865	T11026	T11005	ccomp	exerts,shows
R6866	T11027	T11026	nsubj	Atrx,exerts
R6867	T11028	T11029	det	a,effect
R6868	T11029	T11026	dobj	effect,exerts
R6869	T11030	T11029	amod	major,effect
R6870	T11031	T11026	prep	on,exerts
R6871	T11032	T11033	advmod	terminally,differentiating
R6872	T11033	T11034	amod	differentiating,neurons
R6873	T11034	T11031	pobj	neurons,on
R6874	T11035	T11005	punct	.,shows
R6875	T11037	T11038	amod	Conditional,inactivation
R6876	T11038	T11039	nsubj	inactivation,is
R6877	T11040	T11038	prep	of,inactivation
R6878	T11041	T11040	pobj	Atrx,of
R6879	T11042	T11038	prep	in,inactivation
R6880	T11043	T11044	amod	other,tissues
R6881	T11044	T11042	pobj	tissues,in
R6882	T11045	T11039	acomp	underway,is
R6883	T11046	T11039	punct	.,is
R6884	T11048	T11049	advmod	Here,shown
R6885	T11050	T11049	nsubj	we,shown
R6886	T11051	T11049	aux	have,shown
R6887	T11052	T11053	mark	that,causes
R6888	T11053	T11049	ccomp	causes,shown
R6889	T11054	T11055	npadvmod	animal,wide
R6890	T11055	T11057	amod	wide,disruption
R6891	T11056	T11055	punct	-,wide
R6892	T11057	T11053	nsubj	disruption,causes
R6893	T11058	T11057	prep	of,disruption
R6894	T11059	T11060	det	the,gene
R6895	T11060	T11058	pobj	gene,of
R6896	T11061	T11060	compound	Atrx,gene
R6897	T11062	T11063	det	a,phenotype
R6898	T11063	T11053	dobj	phenotype,causes
R6899	T11064	T11063	amod	severe,phenotype
R6900	T11065	T11066	amod	embryonic,lethal
R6901	T11066	T11063	amod	lethal,phenotype
R6902	T11067	T11066	punct	-,lethal
R6903	T11068	T11049	punct	", ",shown
R6904	T11069	T11049	advcl	revealing,shown
R6905	T11070	T11071	det	an,role
R6906	T11071	T11069	dobj	role,revealing
R6907	T11072	T11071	amod	essential,role
R6908	T11073	T11071	prep	for,role
R6909	T11074	T11073	pobj	Atrx,for
R6910	T11075	T11071	prep	in,role
R6911	T11076	T11077	det	the,formation
R6912	T11077	T11075	pobj	formation,in
R6913	T11078	T11077	prep	of,formation
R6914	T11079	T11080	det	the,trophoblast
R6915	T11080	T11078	pobj	trophoblast,of
R6916	T11081	T11080	amod	murine,trophoblast
R6917	T11082	T11049	punct	.,shown
R6918	T11084	T11085	prep	In,appears
R6919	T11086	T11084	pobj	addition,In
R6920	T11087	T11085	punct	", ",appears
R6921	T11088	T11085	nsubj	Atrx,appears
R6922	T11089	T11090	aux	to,escape
R6923	T11090	T11085	xcomp	escape,appears
R6924	T11091	T11092	amod	imprinted,chromosome
R6925	T11092	T11095	compound	chromosome,inactivation
R6926	T11093	T11092	compound	X,chromosome
R6927	T11094	T11092	punct	-,chromosome
R6928	T11095	T11090	dobj	inactivation,escape
R6929	T11096	T11090	prep	in,escape
R6930	T11097	T11098	det	the,tissues
R6931	T11098	T11096	pobj	tissues,in
R6932	T11099	T11098	amod	extraembryonic,tissues
R6933	T11100	T11098	prep	of,tissues
R6934	T11101	T11102	det	some,mice
R6935	T11102	T11100	pobj	mice,of
R6936	T11103	T11102	nmod	carrier,mice
R6937	T11104	T11103	amod	female,carrier
R6938	T11105	T11085	punct	.,appears

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7343	238-242	PR_EXT:000004503	denotes	Atrx
T7344	246-254	CL:0002322	denotes	ES Cells
T7345	249-254	CL_GO_EXT:cell	denotes	Cells
T7346	255-259	PR_EXT:000004503	denotes	Atrx
T7347	259-263	SO_EXT:sequence_nullness	denotes	null
T7348	264-272	CL:0002322	denotes	ES cells
T7349	267-272	CL_GO_EXT:cell	denotes	cells
T7350	437-441	PR_EXT:000004503	denotes	Atrx
T7351	452-461	GO:0010467	denotes	expressed
T7352	465-473	CL:0002322	denotes	ES cells
T7353	468-473	CL_GO_EXT:cell	denotes	cells
T7354	511-515	PR_EXT:000004503	denotes	Atrx
T7355	526-532	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7356	558-563	CL_GO_EXT:cell	denotes	cells
T7357	585-589	PR_EXT:000004503	denotes	Atrx
T7358	590-596	SO_EXT:0001023	denotes	allele
T7359	627-640	GO_PATO_EXT:cell_proliferation_or_proliferativity	denotes	proliferative
T7360	650-654	PR_EXT:000004503	denotes	Atrx
T7361	654-658	SO_EXT:sequence_nullness	denotes	null
T7362	659-667	CL:0002322	denotes	ES cells
T7363	662-667	CL_GO_EXT:cell	denotes	cells
T7364	718-727	GO:0006915	denotes	apoptosis
T7365	749-761	GO_EXT:positive_regulation	denotes	up-regulated
T7366	765-773	CL:0002322	denotes	ES cells
T7367	768-773	CL_GO_EXT:cell	denotes	cells
T7368	782-786	PR_EXT:000004503	denotes	Atrx
T7369	818-822	PR_EXT:000004503	denotes	Atrx
T7370	822-826	SO_EXT:sequence_nullness	denotes	null
T7371	835-840	NCBITaxon:10088	denotes	mouse
T7372	841-848	UBERON:0000922	denotes	embryos
T7373	902-906	PR_EXT:000004503	denotes	Atrx
T7374	930-939	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T7375	958-973	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T7376	974-979	CL_GO_EXT:cell	denotes	cells
T7377	987-996	UBERON:0000922	denotes	embryonic
T7378	997-1003	UBERON:0001851	denotes	cortex
T7379	1012-1017	GO:0007567	denotes	natal
T7380	1018-1029	UBERON_EXT:hippocampus_proper_or_hippocampal_formation	denotes	hippocampus
T7381	1036-1040	PR_EXT:000004503	denotes	Atrx
T7382	1041-1051	GO:0010467	denotes	expression
T7383	1082-1087	NCBITaxon:10088	denotes	mouse
T7384	1088-1097	UBERON:0001890	denotes	forebrain
T7385	1108-1112	PR_EXT:000004503	denotes	Atrx
T7386	1113-1117	SO:0000359	denotes	flox
T7387	1118-1124	SO_EXT:0001023	denotes	allele
T7388	1150-1155	NCBITaxon:9606	denotes	human
T7389	1156-1160	PR_EXT:000004503	denotes	ATRX
T7390	1161-1168	CHEBI_PR_EXT:protein	denotes	protein
T7391	1202-1209	GO:0032991	denotes	complex
T7392	1215-1219	PR_EXT:000006283	denotes	Daxx
T7393	1227-1234	CHEBI_PR_EXT:protein	denotes	protein
T7394	1289-1312	GO:0042981	denotes	regulation of apoptosis
T7395	1357-1362	NCBITaxon:10088	denotes	mouse
T7396	1363-1367	PR_EXT:000004503	denotes	Atrx
T7397	1368-1372	PR_EXT:000006283	denotes	Daxx
T7398	1373-1380	GO:0032991	denotes	complex
T7399	1401-1405	PR_EXT:000004503	denotes	Atrx
T7400	1406-1413	CHEBI_PR_EXT:protein	denotes	protein
T7401	1451-1460	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T7402	1461-1469	GO_EXT:reaction_or_response	denotes	response
T7403	1500-1508	CL:0002322	denotes	ES cells
T7404	1503-1508	CL_GO_EXT:cell	denotes	cells
T7405	1543-1552	GO:0006915	denotes	apoptosis
T7406	1573-1581	GO_EXT:reaction_or_response	denotes	response
T7407	1610-1614	PR_EXT:000004503	denotes	Atrx
T7408	1622-1626	CL_GO_EXT:cell	denotes	cell
T7409	1669-1678	GO:0006915	denotes	apoptosis
T7410	1695-1699	PR_EXT:000004503	denotes	Atrx
T7411	1700-1706	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7412	1707-1716	UBERON:0001890	denotes	forebrain
T7413	1747-1751	PR_EXT:000004503	denotes	Atrx
T7414	1768-1783	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8062	1809-1813	PR_EXT:000004503	denotes	Atrx
T8063	1836-1841	NCBITaxon:10088	denotes	Mouse
T8064	1842-1853	UBERON:0000088	denotes	Trophoblast
T8065	1867-1871	PR_EXT:000004503	denotes	Atrx
T8066	1871-1875	SO_EXT:sequence_nullness	denotes	null
T8067	1876-1880	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T8068	1881-1885	NCBITaxon:10088	denotes	mice
T8069	1905-1912	UBERON:0000922	denotes	embryos
T8070	1913-1916	GO:0016265	denotes	die
T8071	1943-1948	GO:0016265	denotes	death
T8072	1950-1954	PR_EXT:000004503	denotes	Atrx
T8073	1954-1958	SO_EXT:sequence_nullness	denotes	null
T8074	1959-1966	UBERON:0000922	denotes	embryos
T8075	1994-2001	GO:0007067	denotes	mitotic
T8076	2022-2035	GO_PATO_EXT:cell_proliferation_or_proliferativity	denotes	proliferative
T8077	2057-2066	UBERON:0000922	denotes	embryonic
T8078	2086-2095	UBERON:0004716	denotes	conceptus
T8079	2133-2137	PR_EXT:000004503	denotes	Atrx
T8080	2137-2141	SO_EXT:sequence_nullness	denotes	null
T8081	2142-2149	UBERON:0000922	denotes	embryos
T8082	2194-2205	UBERON:0000088	denotes	trophoblast
T8083	2250-2254	CL:0002488	denotes	TGCs
T8084	2271-2280	UBERON:0004716	denotes	conceptus
T8085	2316-2334	UBERON:0004364	denotes	ectoplacental cone
T8086	2355-2362	_FRAGMENT	denotes	diploid
T8087	2369-2373	CL:0000415	denotes	cell
T8088	2363-2373	CL:0002488	denotes	giant cell
T8089	2369-2373	CL_GO_EXT:cell	denotes	cell
T8090	2391-2395	CL:0002488	denotes	TGCs
T8091	2407-2421	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T8092	2427-2434	GO:0007067	denotes	mitotic
T8093	2435-2440	CL_GO_EXT:cell	denotes	cells
T8094	2465-2475	UBERON:0000483	denotes	epithelial
T8095	2506-2514	UBERON:0001987	denotes	placenta
T8096	2551-2556	CL_GO_EXT:cell	denotes	cells
T8097	2564-2571	UBERON:0002450	denotes	decidua
T8098	2600-2605	CL_GO_EXT:cell	denotes	cells
T8099	2658-2665	UBERON:0000995	denotes	uterine
T8100	2666-2672	UBERON:0000479	denotes	tissue
T8101	2724-2731	UBERON:0002450	denotes	decidua
T8102	2738-2750	GO:0007566	denotes	implantation
T8103	2758-2767	GO:0046903	denotes	secreting
T8104	2768-2776	CHEBI_GO_EXT:hormone	denotes	hormones
T8105	2782-2790	GO:0065007	denotes	regulate
T8106	2810-2816	GO_EXT:biological_growth_entity_or_process	denotes	growth
T8107	2829-2833	PR_EXT:000004503	denotes	Atrx
T8108	2833-2837	SO_EXT:sequence_nullness	denotes	null
T8109	2838-2845	UBERON:0000922	denotes	embryos
T8110	2856-2863	GO:0007566	denotes	implant
T8111	2874-2883	GO_EXT:fatality_or_lethality	denotes	lethality
T8112	2923-2926	CL:0002488	denotes	TGC
T8113	2962-2971	UBERON:0000922	denotes	Embryonic
T8114	2972-2981	GO_EXT:fatality_or_lethality	denotes	lethality
T8115	2985-2989	NCBITaxon:10088	denotes	mice
T8116	3008-3012	PR_EXT:000004503	denotes	Atrx
T8117	3093-3098	NCBITaxon:9606	denotes	human
T8118	3103-3104	GO:0000805	denotes	X
T8119	3147-3151	PR_EXT:000004503	denotes	Atrx
T8120	3159-3170	UBERON:0000088	denotes	trophoblast
T8121	3186-3190	NCBITaxon:10088	denotes	mice
T8122	3200-3204	PR_EXT:000004503	denotes	ATRX
T8123	3240-3245	NCBITaxon:9606	denotes	human
T8124	3246-3257	UBERON:0000088	denotes	trophoblast
T8125	3271-3276	GO:0007567	denotes	birth
T8126	3287-3293	UBERON_EXT:baby_or_infant	denotes	babies
T8127	3303-3304	GO:0000805	denotes	X
T8128	3413-3417	NCBITaxon:10088	denotes	mice
T8129	3430-3434	PR_EXT:000004503	denotes	Atrx
T8130	3443-3451	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T8131	3469-3482	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8132	3514-3518	PR_EXT:000004503	denotes	Atrx
T8133	3519-3526	CHEBI_PR_EXT:protein	denotes	protein
T8134	3573-3582	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8135	3600-3605	NCBITaxon:9606	denotes	human
T8136	3610-3611	GO:0000805	denotes	X
T8137	3657-3664	SO_EXT:0001023	denotes	alleles
T8138	3683-3687	PR_EXT:000004503	denotes	ATRX
T8139	3688-3695	CHEBI_PR_EXT:protein	denotes	protein
T8140	3735-3745	SO_EXT:sequence_truncation_process	denotes	truncating
T8141	3746-3755	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8142	3794-3800	GO_EXT:0016887	denotes	ATPase
T8143	3813-3817	PR_EXT:000004503	denotes	ATRX
T8144	3856-3874	NCBITaxon:10376	denotes	Epstein-Barr virus
T8145	3875-3886	GO:0009294	denotes	transformed
T8146	3887-3898	CL:0000542	denotes	lymphocytes
T8147	3906-3911	NCBITaxon:9606	denotes	human
T8148	4017-4021	SO_EXT:sequence_nullness	denotes	null
T8149	4022-4026	PR_EXT:000004503	denotes	ATRX
T8150	4027-4033	SO_EXT:0001023	denotes	allele
T8151	4040-4045	NCBITaxon:9606	denotes	human
T8152	4089-4094	NCBITaxon:10088	denotes	mouse
T8153	4120-4124	PR_EXT:000004503	denotes	ATRX
T8154	4125-4132	CHEBI_PR_EXT:protein	denotes	protein
T8155	4154-4159	NCBITaxon:9606	denotes	human
T8156	4229-4233	PR_EXT:000004503	denotes	Atrx
T8157	4241-4247	NCBITaxon:39107	denotes	murine
T8158	4248-4261	UBERON:0004345	denotes	trophectoderm
T8159	4288-4297	GO_EXT:fatality_or_lethality	denotes	lethality
T8160	4310-4314	PR_EXT:000004503	denotes	Atrx
T8161	4314-4318	SO_EXT:sequence_nullness	denotes	null
T8162	4319-4326	UBERON:0000922	denotes	embryos
T8163	4374-4378	PR_EXT:000004503	denotes	Atrx
T8164	4412-4419	UBERON:0000479	denotes	tissues
T8165	4427-4433	UBERON:0000922	denotes	embryo
T8166	4463-4467	PR_EXT:000004503	denotes	Atrx
T8167	4478-4487	GO:0010467	denotes	expressed
T8168	4521-4527	UBERON:0000922	denotes	embryo
T8169	4574-4578	PR_EXT:000004503	denotes	Atrx
T8170	4628-4643	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T8171	4644-4651	UBERON:0000479	denotes	tissues
T8172	4698-4704	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8173	4705-4712	UBERON:0000922	denotes	embryos
T8174	4717-4724	SO_EXT:sequence_rescue_process	denotes	rescued
T8175	4730-4739	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T8176	4740-4762	UBERON:0005292	denotes	extraembryonic tissues
T8177	4801-4805	PR_EXT:000004503	denotes	Atrx
T8178	4819-4824	NCBITaxon:10088	denotes	mouse
T8179	4913-4917	PR_EXT:000004503	denotes	Atrx
T8180	4918-4922	SO:0000359	denotes	flox
T8181	4923-4929	SO_EXT:0001023	denotes	allele
T8182	4968-4974	UBERON:0000479	denotes	tissue
T8183	4988-4998	SO_EXT:0000902	denotes	transgenes
T8184	5075-5079	PR_EXT:000004503	denotes	Atrx
T8185	5087-5095	CL:0000540	denotes	neuronal
T8186	5096-5111	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8187	5115-5120	UBERON:0007023	denotes	adult
T8188	5121-5125	NCBITaxon:10088	denotes	mice
T8189	5154-5158	PR_EXT:000004503	denotes	Atrx
T8190	5195-5200	NCBITaxon:10088	denotes	mouse
T8191	5266-5270	PR_EXT:000004503	denotes	Atrx
T8192	5280-5285	CL_GO_EXT:cell	denotes	cells
T8193	5302-5309	UBERON:0000479	denotes	tissues
T8194	5321-5327	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T8195	5328-5332	NCBITaxon:10088	denotes	mice
T8196	5340-5347	UBERON:0000479	denotes	tissues
T8197	5379-5383	PR_EXT:000004503	denotes	Atrx
T8198	5397-5401	PR_EXT:000004503	denotes	Atrx
T8199	5411-5416	CL_GO_EXT:cell	denotes	cells
T8200	5439-5440	GO:0000805	denotes	X
T8201	5439-5453	GO:0009048	denotes	X-inactivation
T8202	5490-5494	PR_EXT:000004503	denotes	Atrx
T8203	5522-5527	NCBITaxon:10088	denotes	mouse
T8204	5528-5533	SO_EXT:0000704	denotes	genes
T8205	5580-5592	GO:0007566	denotes	implantation
T8206	5593-5602	GO_EXT:fatality_or_lethality	denotes	lethality
T8207	5618-5629	UBERON:0000088	denotes	trophoblast
T8208	5633-5642	UBERON:0001987	denotes	placental
T8209	5754-5758	PR_EXT:000004503	denotes	Atrx
T8210	5762-5773	UBERON:0000088	denotes	trophoblast
T8211	5787-5791	PR_EXT:000004503	denotes	Atrx
T8212	5792-5798	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8213	5799-5806	UBERON:0000922	denotes	embryos
T8214	5829-5836	UBERON:0000922	denotes	embryos
T8215	5885-5901	_FRAGMENT	denotes	specification of
T8216	5914-5924	GO:0048866	denotes	stem cells
T8217	5902-5913	UBERON:0000088	denotes	trophoblast
T8218	5902-5913	_FRAGMENT	denotes	trophoblast
T8219	5919-5924	CL:0000351	denotes	cells
T8220	5914-5924	CL:0000034	denotes	stem cells
T8221	5919-5924	CL_GO_EXT:cell	denotes	cells
T8222	5934-5938	PR_EXT:000005296	denotes	Cdx2
T8223	5946-5955	CL:0000034	denotes	stem cell
T8224	5946-5967	GO:0019827	denotes	stem cell maintenance
T8225	5946-5955	_FRAGMENT	denotes	stem cell
T8226	5972-5985	GO:0072089	denotes	proliferation
T8227	5951-5955	CL_GO_EXT:cell	denotes	cell
T8228	5995-6000	PR_EXT:000003463	denotes	Eomes
T8229	6003-6007	PR_EXT:000005296	denotes	Cdx2
T8230	6008-6014	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8231	6015-6022	UBERON:0000922	denotes	embryos
T8232	6031-6038	GO:0007566	denotes	implant
T8233	6043-6046	GO:0016265	denotes	die
T8234	6083-6088	PR_EXT:000003463	denotes	Eomes
T8235	6089-6095	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8236	6096-6107	UBERON:0000358	denotes	blastocysts
T8237	6108-6115	GO:0007566	denotes	implant
T8238	6125-6131	UBERON:0000995	denotes	uterus
T8239	6155-6167	GO:0007566	denotes	implantation
T8240	6194-6203	_FRAGMENT	denotes	embryonic
T8241	6222-6232	UBERON:0002050	denotes	structures
T8242	6207-6232	UBERON:0000478	denotes	extraembryonic structures
T8243	6252-6256	PR_EXT:000004503	denotes	Atrx
T8244	6257-6263	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8245	6264-6271	UBERON:0000922	denotes	embryos
T8246	6272-6279	GO:0007566	denotes	implant
T8247	6317-6337	UBERON:0002050	denotes	embryonic structures
T8248	6354-6358	PR_EXT:000004503	denotes	Atrx
T8249	6359-6365	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8250	6411-6415	NCBITaxon:10088	denotes	mice
T8251	6436-6441	CHEBI_EXT:22695	denotes	basic
T8252	6442-6447	SO_EXT:0001114	denotes	helix
T8253	6453-6458	SO_EXT:0001114	denotes	helix
T8254	6459-6472	GO_EXT:transcription	denotes	transcription
T8255	6459-6479	GO_EXT:transcription_factor	denotes	transcription factor
T8256	6480-6485	PR_EXT:000008439	denotes	Hand1
T8257	6487-6492	PR_EXT:000008439	denotes	Hand1
T8258	6493-6499	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8259	6558-6567	UBERON:0000922	denotes	embryonic
T8260	6591-6595	PR_EXT:000004503	denotes	Atrx
T8261	6596-6602	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8262	6603-6610	UBERON:0000922	denotes	embryos
T8263	6624-6629	PR_EXT:000008439	denotes	Hand1
T8264	6668-6686	UBERON:0004364	denotes	ectoplacental cone
T8265	6702-6706	CL:0002488	denotes	TGCs
T8266	6721-6725	PR_EXT:000004503	denotes	Atrx
T8267	6726-6733	SO_EXT:sequence_altered_entity	denotes	mutants
T8268	6761-6766	PR_EXT:000008439	denotes	Hand1
T8269	6767-6773	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8270	6774-6785	UBERON:0004716	denotes	conceptuses
T8271	6826-6830	PR_EXT:000004503	denotes	Atrx
T8272	6846-6851	PR_EXT:000008439	denotes	Hand1
T8273	6873-6893	CL:0002498	denotes	secondary giant cell
T8274	6889-6893	CL_GO_EXT:cell	denotes	cell
T8275	6889-6903	GO:0048468	denotes	cell formation
T8276	6917-6928	UBERON:0000088	denotes	trophoblast
T8277	6945-6956	UBERON:0000358	denotes	blastocysts
T8278	6974-6979	PR_EXT:000008439	denotes	Hand1
T8279	7005-7020	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8280	7024-7038	CL:0002498	denotes	secondary TGCs
T8281	7059-7070	UBERON:0000088	denotes	trophoblast
T8282	7059-7076	CL:0000351	denotes	trophoblast cells
T8283	7071-7076	CL_GO_EXT:cell	denotes	cells
T8284	7112-7130	UBERON:0004364	denotes	ectoplacental cone
T8285	7168-7172	PR_EXT:000004503	denotes	Atrx
T8286	7178-7183	PR_EXT:000008439	denotes	Hand1
T8287	7184-7190	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8288	7226-7230	PR_EXT:000004503	denotes	Atrx
T8289	7241-7256	GO_EXT:transcription	denotes	transcriptional
T8290	7257-7266	GO_EXT:regulator	denotes	regulator
T8291	7280-7289	GO:0000785	denotes	chromatin
T8292	7345-7349	PR_EXT:000004503	denotes	Atrx
T8293	7362-7371	GO_EXT:regulator	denotes	regulator
T8294	7375-7380	PR_EXT:000008439	denotes	Hand1
T8295	7381-7391	GO:0010467	denotes	expression
T8296	7434-7443	GO_EXT:regulator	denotes	regulator
T8297	7477-7492	GO_EXT:transcription	denotes	transcriptional
T8298	7504-7509	PR_EXT:000008439	denotes	Hand1
T8299	7541-7546	UBERON:0000955	denotes	brain
T8300	7556-7560	PR_EXT:000004503	denotes	Atrx
T8301	7570-7574	NCBITaxon:10088	denotes	mice
T8302	7614-7629	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T8303	7630-7637	CL:0000540	denotes	neurons
T8304	7648-7662	CL:0002498	denotes	secondary TGCs
T8305	7689-7693	PR_EXT:000004503	denotes	Atrx
T8306	7755-7769	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T8307	7770-7777	UBERON:0000479	denotes	tissues
T8308	7796-7801	NCBITaxon:10088	denotes	mouse
T8309	7845-7849	PR_EXT:000004503	denotes	Atrx
T8310	7868-7878	GO:0010467	denotes	expression
T8311	7887-7893	UBERON:0000479	denotes	tissue
T8312	7903-7908	SO_EXT:0000704	denotes	genes
T8313	7936-7951	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8314	7974-7980	CHEBI:5386	denotes	globin
T8315	7981-7986	SO_EXT:0000704	denotes	genes
T8316	8007-8022	GO_EXT:transcription	denotes	transcriptional
T8317	8034-8044	GO:0065007	denotes	regulation
T8318	8048-8053	NCBITaxon:9606	denotes	human
T8319	8054-8058	PR_EXT:000004503	denotes	ATRX
T8320	8076-8085	GO:0010467	denotes	expressed
T8321	8115-8130	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8322	8142-8151	CL:0000764	denotes	erythroid
T9728	8162-8166	PR_EXT:000004503	denotes	Atrx
T9729	8175-8199	GO:0060819	denotes	Imprinted X-Inactivation
T9730	8185-8186	GO:0000805	denotes	X
T9731	8203-8225	UBERON:0005292	denotes	Extraembryonic Tissues
T9732	8237-8243	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	Female
T9733	8244-8248	NCBITaxon:10088	denotes	Mice
T9734	8310-8316	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T9735	8317-8324	UBERON:0000922	denotes	embryos
T9736	8349-8353	PR_EXT:000004503	denotes	Atrx
T9737	8354-8356	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9738	8357-8363	SO_EXT:0001023	denotes	allele
T9739	8397-8421	GO:0060819	denotes	imprinted X-inactivation
T9740	8407-8408	GO:0000805	denotes	X
T9741	8440-8448	GO:0016458	denotes	silences
T9742	8456-8466	GO_SO_EXT:chromosome	denotes	chromosome
T9743	8479-8488	UBERON:0000922	denotes	embryonic
T9744	8504-8510	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T9745	8511-8517	NCBITaxon:39107	denotes	murine
T9746	8518-8525	UBERON:0000479	denotes	tissues
T9747	8532-8541	GO:0016458	denotes	Silencing
T9748	8549-8553	PR_EXT:000004503	denotes	Atrx
T9749	8554-8556	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9750	8557-8563	SO_EXT:0001023	denotes	allele
T9751	8590-8597	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9752	8598-8602	SO_EXT:sequence_nullness	denotes	null
T9753	8607-8611	PR_EXT:000004503	denotes	Atrx
T9754	8619-8641	UBERON:0005292	denotes	extraembryonic tissues
T9755	8672-8682	GO_SO_EXT:chromosome	denotes	chromosome
T9756	8695-8699	PR_EXT:000004503	denotes	Atrx
T9757	8708-8714	SO_EXT:0001023	denotes	allele
T9758	8757-8761	PR_EXT:000004503	denotes	Atrx
T9759	8770-8777	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9760	8811-8820	GO:0000003	denotes	reproduce
T9761	8853-8860	GO:0016458	denotes	silence
T9762	8884-8888	PR_EXT:000007899	denotes	Atrx
T9763	8889-8891	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9764	8892-8898	SO_EXT:0001023	denotes	allele
T9765	8906-8928	UBERON:0005292	denotes	extraembryonic tissues
T9766	8940-8947	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9767	8992-8996	PR_EXT:000007899	denotes	Atrx
T9768	8996-9000	SO_EXT:sequence_nullness	denotes	null
T9769	9001-9006	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T9770	9012-9016	PR_EXT:000004503	denotes	Atrx
T9771	9017-9024	CHEBI_PR_EXT:protein	denotes	protein
T9772	9075-9086	UBERON:0000088	denotes	trophoblast
T9773	9133-9138	NCBITaxon:10088	denotes	mouse
T9774	9156-9160	PR_EXT:000004503	denotes	Atrx
T9775	9169-9176	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9776	9227-9236	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T9777	9246-9252	NCBITaxon:39107	denotes	murine
T9778	9253-9254	GO:0000805	denotes	X
T9779	9262-9267	SO_EXT:0000704	denotes	genes
T9780	9302-9311	UBERON:0000922	denotes	embryonic
T9781	9365-9373	PR_EXT:000006498	denotes	dyskerin
T9782	9375-9379	PR_EXT:000006498	denotes	Dkc1
T9783	9382-9401	CHEBI:14314	denotes	glucose 6-phosphate
T9784	9382-9415	GO_PR_EXT:glucose_6_phosphate_dehydrogenase	denotes	glucose 6-phosphate dehydrogenase
T9785	9417-9421	GO_PR_EXT:glucose_6_phosphate_dehydrogenase	denotes	G6PD
T9786	9428-9441	PR_EXT:000005430	denotes	choroideremia
T9787	9443-9446	PR_EXT:000005430	denotes	Chm
T9788	9448-9453	SO_EXT:0000704	denotes	genes
T9789	9460-9469	UBERON:0000922	denotes	embryonic
T9790	9470-9479	GO_EXT:fatality_or_lethality	denotes	lethality
T9791	9483-9487	SO_EXT:sequence_nullness	denotes	null
T9792	9488-9492	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T9793	9493-9500	UBERON:0000922	denotes	embryos
T9794	9529-9538	UBERON:0000922	denotes	embryonic
T9795	9547-9554	UBERON:0000479	denotes	tissues
T9796	9564-9570	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	Female
T9797	9571-9575	NCBITaxon:10088	denotes	mice
T9798	9585-9594	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T9799	9604-9609	SO_EXT:0000704	denotes	genes
T9800	9638-9650	GO:0000805	denotes	X chromosome
T9801	9640-9650	GO_SO_EXT:chromosome	denotes	chromosome
T9802	9656-9659	GO:0016265	denotes	die
T9803	9678-9685	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9804	9703-9711	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T9805	9722-9732	GO_SO_EXT:chromosome	denotes	chromosome
T9806	9755-9759	PR_EXT:000004503	denotes	Atrx
T9807	9767-9772	SO_EXT:0000704	denotes	genes
T9808	9797-9801	CL_GO_EXT:cell	denotes	cell
T9809	9802-9808	GO_EXT:biological_growth_entity_or_process	denotes	growth
T9810	9874-9879	CL_GO_EXT:cell	denotes	cells
T9811	9887-9909	UBERON:0005292	denotes	extraembryonic tissues
T9812	9913-9920	GO:0010467	denotes	express
T9813	9949-9961	GO:0000805	denotes	X chromosome
T9814	9951-9961	GO_SO_EXT:chromosome	denotes	chromosome
T9815	9973-9983	GO:0010467	denotes	expression
T9816	10000-10004	PR_EXT:000004503	denotes	Atrx
T9817	10005-10007	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9818	10008-10014	SO_EXT:0001023	denotes	allele
T9819	10036-10058	UBERON:0005292	denotes	extraembryonic tissues
T9820	10066-10070	PR_EXT:000004503	denotes	Atrx
T9821	10079-10086	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9822	10129-10130	GO:0000805	denotes	X
T9823	10138-10143	SO_EXT:0000704	denotes	genes
T9824	10145-10157	_FRAGMENT	denotes	silencing of
T9825	10167-10171	GO:0016458	denotes	gene
T9826	10162-10166	PR_EXT:000004503	denotes	Atrx
T9827	10167-10171	SO_EXT:0000704	denotes	gene
T9828	10248-10252	PR_EXT:000004503	denotes	Atrx
T9829	10284-10294	GO_SO_EXT:chromosome	denotes	chromosome
T9830	10298-10320	UBERON:0005292	denotes	extraembryonic tissues
T9831	10378-10382	PR_EXT:000004503	denotes	Atrx
T9832	10396-10402	SO_EXT:0001023	denotes	allele
T9833	10417-10425	GO:0016458	denotes	silenced
T9834	10438-10443	NCBITaxon:10088	denotes	mouse
T9835	10444-10455	UBERON:0000088	denotes	trophoblast
T9836	10444-10455	_FRAGMENT	denotes	trophoblast
T9837	10461-10465	CL:0000351	denotes	cell
T9838	10456-10465	CL:0000034	denotes	stem cell
T9839	10461-10465	CL_GO_EXT:cell	denotes	cell
T9840	10493-10497	PR_EXT:000004503	denotes	Atrx
T9841	10523-10547	GO:0060819	denotes	imprinted X-inactivation
T9842	10533-10534	GO:0000805	denotes	X
T9843	10555-10577	UBERON:0005292	denotes	extraembryonic tissues
T9844	10581-10590	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9845	10591-10598	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9846	10610-10620	GO:0010467	denotes	expression
T9847	10638-10642	PR_EXT:000004503	denotes	Atrx
T9848	10643-10645	SO_EXT:wild_type_entity_or_quality	denotes	WT
T9849	10646-10652	SO_EXT:0001023	denotes	allele
T9850	10683-10689	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T9851	10706-10710	PR_EXT:000004503	denotes	Atrx
T9852	10711-10715	SO_EXT:sequence_nullness	denotes	null
T9853	10716-10722	SO_EXT:0001023	denotes	allele
T9854	10831-10855	GO:0060819	denotes	imprinted X-inactivation
T9855	10841-10842	GO:0000805	denotes	X
T9856	10896-10901	NCBITaxon:10088	denotes	mouse
T9857	10902-10924	UBERON:0005292	denotes	extraembryonic tissues
T9858	10931-10950	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	population of cells
T9859	10945-10950	CL_GO_EXT:cell	denotes	cells
T9860	11011-11023	GO:0000805	denotes	X chromosome
T9861	11013-11023	GO_SO_EXT:chromosome	denotes	chromosome
T9862	11068-11073	CL_GO_EXT:cell	denotes	cells
T9863	11161-11171	GO_SO_EXT:chromosome	denotes	chromosome
T9864	11234-11244	GO:0010467	denotes	expression
T9865	11271-11272	GO:0000805	denotes	X
T9866	11280-11284	PR_EXT:000033987	denotes	lacZ
T9867	11306-11316	SO_EXT:0000902	denotes	transgenes
T9868	11330-11338	GO:0016458	denotes	silenced
T9869	11353-11366	_FRAGMENT	denotes	population of
T9870	11382-11387	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cells
T9871	11367-11387	CL:0000349	denotes	extraembryonic cells
T9872	11372-11381	UBERON:0000922	denotes	embryonic
T9873	11382-11387	CL_GO_EXT:cell	denotes	cells
T9874	11429-11442	_FRAGMENT	denotes	population of
T9875	11458-11463	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cells
T9876	11443-11463	CL:0000349	denotes	extraembryonic cells
T9877	11448-11457	UBERON:0000922	denotes	embryonic
T9878	11458-11463	CL_GO_EXT:cell	denotes	cells
T9879	11517-11528	GO:0006260	denotes	replication
T9880	11532-11541	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T9881	11638-11645	UBERON:0000922	denotes	embryos
T9882	11651-11659	CL_GO_EXT:cell	denotes	cellular
T9883	11651-11659	_FRAGMENT	denotes	cellular
T9884	11663-11673	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	population
T9885	11698-11708	GO_SO_EXT:chromosome	denotes	chromosome
T9886	11754-11763	GO:0071514	denotes	imprinted
T9887	11764-11769	CL_GO_EXT:cell	denotes	cells
T9888	11778-11787	UBERON:0000922	denotes	embryonic
T9889	11811-11820	GO:0016458	denotes	silencing
T9890	11839-11843	CL_GO_EXT:cell	denotes	cell
T9891	11839-11843	_FRAGMENT	denotes	cell
T9892	11854-11869	GO:0030154	denotes	differentiation
T9893	11844-11850	GO_EXT:biological_growth_entity_or_process	denotes	growth
T9894	11963-11973	GO:0071514	denotes	imprinting
T9895	12022-12033	SO_EXT:0000704	denotes	genetically
T9896	12044-12051	UBERON:0000922	denotes	embryos
T9897	12121-12128	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9898	12147-12153	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9899	12154-12161	SO_EXT:0001023	denotes	alleles
T9900	12165-12170	SO_EXT:0000704	denotes	genes
T9901	12197-12206	UBERON:0000922	denotes	embryonic
T9902	12245-12252	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9903	12277-12290	_FRAGMENT	denotes	population of
T9904	12300-12305	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cells
T9905	12300-12305	CL_GO_EXT:cell	denotes	cells
T9906	12457-12461	PR_EXT:000004503	denotes	Atrx
T9907	12470-12477	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T9908	12498-12503	GO:0016265	denotes	dying
T9909	12600-12615	_FRAGMENT	denotes	inactivation of
T9910	12620-12630	GO:0060817	denotes	paternal X
T9911	12629-12630	GO:0000805	denotes	X
T9912	12656-12661	CL_GO_EXT:cell	denotes	cells
T9913	12684-12688	PR_EXT:000004503	denotes	Atrx
T9914	12689-12693	SO_EXT:0000704	denotes	gene
T9915	12712-12717	CL_GO_EXT:cell	denotes	cells
T9916	12767-12771	PR_EXT:000004503	denotes	Atrx
T9917	12786-12792	SO_EXT:0001023	denotes	allele
T9918	12836-12845	GO:0016458	denotes	silencing
T9919	12877-12882	SO_EXT:0000704	denotes	genes
T9920	12899-12911	GO:0000805	denotes	X chromosome
T9921	12901-12911	GO_SO_EXT:chromosome	denotes	chromosome
T9922	12962-12977	_FRAGMENT	denotes	inactivation of
T9923	12989-13002	GO:0060817	denotes	Xp chromosome
T9924	12992-13002	GO_SO_EXT:chromosome	denotes	chromosome
T9925	13010-13019	UBERON:0000922	denotes	embryonic
T9926	13020-13029	GO_EXT:fatality_or_lethality	denotes	lethality
T9927	13039-13046	SO_EXT:0001023	denotes	allelic
T9928	13047-13057	GO:0010467	denotes	expression
T9929	13061-13062	GO:0000805	denotes	X
T9930	13070-13075	SO_EXT:0000704	denotes	genes
T9931	13083-13094	UBERON:0000088	denotes	trophoblast
T10885	13114-13115	GO:0000805	denotes	X
T10886	13138-13143	NCBITaxon:9606	denotes	human
T10887	13144-13151	SO_EXT:0000704	denotes	genetic
T10888	13182-13191	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T10889	13197-13206	GO:0000785	denotes	chromatin
T10890	13197-13218	GO:0006338	denotes	chromatin remodelling
T10891	13257-13261	PR_EXT:000004503	denotes	ATRX
T10892	13273-13277	SO_EXT:0000704	denotes	gene
T10893	13273-13288	GO:0010467	denotes	gene expression
T10894	13314-13318	CL_GO_EXT:cell	denotes	cell
T10895	13319-13328	GO_PATO_EXT:biological_behavior	denotes	behaviour
T10896	13394-13403	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T10897	13416-13417	GO:0000805	denotes	X
T10898	13431-13436	SO_EXT:null_sequence_entity	denotes	nulls
T10899	13545-13549	PR_EXT:000004503	denotes	Atrx
T10900	13568-13573	NCBITaxon:10088	denotes	mouse
T10901	13574-13583	UBERON:0001890	denotes	forebrain
T10902	13598-13602	PR_EXT:000004503	denotes	Atrx
T10903	13603-13607	SO:0000359	denotes	flox
T10904	13608-13614	SO_EXT:0001023	denotes	allele
T10905	13642-13646	PR_EXT:000004503	denotes	Atrx
T10906	13683-13698	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T10907	13699-13706	CL:0000540	denotes	neurons
T10908	13736-13740	PR_EXT:000004503	denotes	Atrx
T10909	13750-13757	UBERON:0000479	denotes	tissues
T10910	13795-13801	NCBITaxon:33208	denotes	animal
T10911	13825-13829	PR_EXT:000004503	denotes	Atrx
T10912	13830-13834	SO_EXT:0000704	denotes	gene
T10913	13851-13860	UBERON:0000922	denotes	embryonic
T10914	13861-13867	GO_EXT:fatality_or_lethality	denotes	lethal
T10915	13911-13915	PR_EXT:000004503	denotes	Atrx
T10916	13940-13946	NCBITaxon:39107	denotes	murine
T10917	13947-13958	UBERON:0000088	denotes	trophoblast
T10918	13973-13977	PR_EXT:000004503	denotes	Atrx
T10919	13996-14031	GO:0060819	denotes	imprinted X-chromosome inactivation
T10920	14006-14018	GO:0000805	denotes	X-chromosome
T10921	14008-14018	GO_SO_EXT:chromosome	denotes	chromosome
T10922	14039-14061	UBERON:0005292	denotes	extraembryonic tissues
T10923	14078-14084	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T10924	14085-14089	NCBITaxon:10088	denotes	mice
T7184	43-47	PR_EXT:000004503	denotes	Atrx
T7185	48-55	CHEBI_PR_EXT:protein	denotes	protein
T7186	59-64	NCBITaxon:10088	denotes	mouse
T7187	147-151	PR_EXT:000004503	denotes	Atrx
T7188	152-159	CHEBI_PR_EXT:protein	denotes	protein
T7189	169-177	CL:0002322	denotes	ES cells
T7190	172-177	CL_GO_EXT:cell	denotes	cells
T7191	182-197	UBERON:0014374	denotes	embryoid bodies
T7192	222-227	NCBITaxon:10088	denotes	mouse
T7193	228-235	UBERON:0000922	denotes	embryos
R4819	T8087	T8086	_lexicallyChainedTo	cell,diploid
R4820	T8216	T8215	_lexicallyChainedTo	stem cells,specification of
R4821	T8219	T8218	_lexicallyChainedTo	cells,trophoblast
R4822	T8226	T8225	_lexicallyChainedTo	proliferation,stem cell
R4823	T8241	T8240	_lexicallyChainedTo	structures,embryonic
R5918	T9825	T9824	_lexicallyChainedTo	gene,silencing of
R5919	T9837	T9836	_lexicallyChainedTo	cell,trophoblast
R5920	T9870	T9869	_lexicallyChainedTo	cells,population of
R5921	T9875	T9874	_lexicallyChainedTo	cells,population of
R5922	T9884	T9883	_lexicallyChainedTo	population,cellular
R5923	T9892	T9891	_lexicallyChainedTo	differentiation,cell
R5924	T9904	T9903	_lexicallyChainedTo	cells,population of
R5925	T9910	T9909	_lexicallyChainedTo	paternal X,inactivation of
R5926	T9923	T9922	_lexicallyChainedTo	Xp chromosome,inactivation of

2_test

Id	Subject	Object	Predicate	Lexical cue
16628246-15668733-85799759	1141-1143	15668733	denotes	20
16628246-12953102-85799760	1221-1222	12953102	denotes	8
16628246-15077145-85799761	1314-1316	15077145	denotes	21
16628246-6895086-85799762	2386-2388	6895086	denotes	22
16628246-10873707-85799763	2573-2575	10873707	denotes	23
16628246-7985020-85799764	2818-2820	7985020	denotes	24
16628246-15668733-85799765	5127-5129	15668733	denotes	20
16628246-11433360-85799766	5671-5673	11433360	denotes	25
16628246-9052785-85799767	6072-6074	9052785	denotes	26
16628246-10716450-85799768	6234-6236	10716450	denotes	27
16628246-9500551-85799769	6708-6710	9500551	denotes	28
16628246-10611232-85799770	7132-7134	10611232	denotes	17
16628246-9500551-85799771	7135-7137	9500551	denotes	28
16628246-15668733-85799772	7639-7641	15668733	denotes	20
16628246-1152998-85799773	8527-8529	1152998	denotes	18
16628246-12400016-85799774	9556-9558	12400016	denotes	29
16628246-12169625-85799774	9556-9558	12169625	denotes	29
16628246-15242790-85799774	9556-9558	15242790	denotes	29
16628246-14661031-85799775	10472-10474	14661031	denotes	32
16628246-7834909-85799776	11286-11288	7834909	denotes	33
16628246-10794075-85799777	11289-11291	10794075	denotes	34
16628246-11252054-85799778	11302-11304	11252054	denotes	35
16628246-1152998-85799779	11575-11577	1152998	denotes	18
16628246-958416-85799780	11578-11580	958416	denotes	36
16628246-11698184-85799781	12053-12055	11698184	denotes	37
16628246-11051544-85799782	12220-12222	11051544	denotes	38
16628246-9009199-85799783	13096-13098	9009199	denotes	39
T69494	1141-1143	15668733	denotes	20
T51832	1221-1222	12953102	denotes	8
T83532	1314-1316	15077145	denotes	21
T47412	2386-2388	6895086	denotes	22
T89259	2573-2575	10873707	denotes	23
T98024	2818-2820	7985020	denotes	24
T95738	5127-5129	15668733	denotes	20
T36669	5671-5673	11433360	denotes	25
T78131	6072-6074	9052785	denotes	26
T46656	6234-6236	10716450	denotes	27
T27799	6708-6710	9500551	denotes	28
T13124	7132-7134	10611232	denotes	17
T42247	7135-7137	9500551	denotes	28
T83367	7639-7641	15668733	denotes	20
T3361	8527-8529	1152998	denotes	18
T78774	9556-9558	12400016	denotes	29
T99673	9556-9558	12169625	denotes	29
T50636	9556-9558	15242790	denotes	29
T87099	10472-10474	14661031	denotes	32
T81121	11286-11288	7834909	denotes	33
T60587	11289-11291	10794075	denotes	34
T75568	11302-11304	11252054	denotes	35
T99758	11575-11577	1152998	denotes	18
T9314	11578-11580	958416	denotes	36
T45193	12053-12055	11698184	denotes	37
T45487	12220-12222	11051544	denotes	38
T9506	13096-13098	9009199	denotes	39

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7297	238-242	PR:000004503	denotes	Atrx
T7298	246-254	CL:0002322	denotes	ES Cells
T7299	255-259	PR:000004503	denotes	Atrx
T7300	264-272	CL:0002322	denotes	ES cells
T7301	437-441	PR:000004503	denotes	Atrx
T7302	452-461	GO:0010467	denotes	expressed
T7303	465-473	CL:0002322	denotes	ES cells
T7304	511-515	PR:000004503	denotes	Atrx
T7305	585-589	PR:000004503	denotes	Atrx
T7306	590-596	SO:0001023	denotes	allele
T7307	650-654	PR:000004503	denotes	Atrx
T7308	659-667	CL:0002322	denotes	ES cells
T7309	718-727	GO:0006915	denotes	apoptosis
T7310	765-773	CL:0002322	denotes	ES cells
T7311	782-786	PR:000004503	denotes	Atrx
T7312	818-822	PR:000004503	denotes	Atrx
T7313	835-840	NCBITaxon:10088	denotes	mouse
T7314	841-848	UBERON:0000922	denotes	embryos
T7315	902-906	PR:000004503	denotes	Atrx
T7316	987-996	UBERON:0000922	denotes	embryonic
T7317	997-1003	UBERON:0001851	denotes	cortex
T7318	1012-1017	GO:0007567	denotes	natal
T7319	1036-1040	PR:000004503	denotes	Atrx
T7320	1041-1051	GO:0010467	denotes	expression
T7321	1082-1087	NCBITaxon:10088	denotes	mouse
T7322	1088-1097	UBERON:0001890	denotes	forebrain
T7323	1108-1112	PR:000004503	denotes	Atrx
T7324	1113-1117	SO:0000359	denotes	flox
T7325	1118-1124	SO:0001023	denotes	allele
T7326	1150-1155	NCBITaxon:9606	denotes	human
T7327	1156-1160	PR:000004503	denotes	ATRX
T7328	1202-1209	GO:0032991	denotes	complex
T7329	1215-1219	PR:000006283	denotes	Daxx
T7330	1289-1312	GO:0042981	denotes	regulation of apoptosis
T7331	1357-1362	NCBITaxon:10088	denotes	mouse
T7332	1363-1367	PR:000004503	denotes	Atrx
T7333	1368-1372	PR:000006283	denotes	Daxx
T7334	1373-1380	GO:0032991	denotes	complex
T7335	1401-1405	PR:000004503	denotes	Atrx
T7336	1500-1508	CL:0002322	denotes	ES cells
T7337	1543-1552	GO:0006915	denotes	apoptosis
T7338	1610-1614	PR:000004503	denotes	Atrx
T7339	1669-1678	GO:0006915	denotes	apoptosis
T7340	1695-1699	PR:000004503	denotes	Atrx
T7341	1707-1716	UBERON:0001890	denotes	forebrain
T7342	1747-1751	PR:000004503	denotes	Atrx
T7865	1809-1813	PR:000004503	denotes	Atrx
T7866	1836-1841	NCBITaxon:10088	denotes	Mouse
T7867	1842-1853	UBERON:0000088	denotes	Trophoblast
T7868	1867-1871	PR:000004503	denotes	Atrx
T7869	1881-1885	NCBITaxon:10088	denotes	mice
T7870	1905-1912	UBERON:0000922	denotes	embryos
T7871	1913-1916	GO:0016265	denotes	die
T7872	1943-1948	GO:0016265	denotes	death
T7873	1950-1954	PR:000004503	denotes	Atrx
T7874	1959-1966	UBERON:0000922	denotes	embryos
T7875	1994-2001	GO:0007067	denotes	mitotic
T7876	2057-2066	UBERON:0000922	denotes	embryonic
T7877	2086-2095	UBERON:0004716	denotes	conceptus
T7878	2133-2137	PR:000004503	denotes	Atrx
T7879	2142-2149	UBERON:0000922	denotes	embryos
T7880	2194-2205	UBERON:0000088	denotes	trophoblast
T7881	2250-2254	CL:0002488	denotes	TGCs
T7882	2271-2280	UBERON:0004716	denotes	conceptus
T7883	2316-2334	UBERON:0004364	denotes	ectoplacental cone
T7884	2355-2362	_FRAGMENT	denotes	diploid
T7885	2369-2373	CL:0000415	denotes	cell
T7886	2363-2373	CL:0002488	denotes	giant cell
T7887	2391-2395	CL:0002488	denotes	TGCs
T7888	2427-2434	GO:0007067	denotes	mitotic
T7889	2465-2475	UBERON:0000483	denotes	epithelial
T7890	2506-2514	UBERON:0001987	denotes	placenta
T7891	2564-2571	UBERON:0002450	denotes	decidua
T7892	2658-2665	UBERON:0000995	denotes	uterine
T7893	2666-2672	UBERON:0000479	denotes	tissue
T7894	2724-2731	UBERON:0002450	denotes	decidua
T7895	2738-2750	GO:0007566	denotes	implantation
T7896	2758-2767	GO:0046903	denotes	secreting
T7897	2782-2790	GO:0065007	denotes	regulate
T7898	2829-2833	PR:000004503	denotes	Atrx
T7899	2838-2845	UBERON:0000922	denotes	embryos
T7900	2856-2863	GO:0007566	denotes	implant
T7901	2923-2926	CL:0002488	denotes	TGC
T7902	2962-2971	UBERON:0000922	denotes	Embryonic
T7903	2985-2989	NCBITaxon:10088	denotes	mice
T7904	3008-3012	PR:000004503	denotes	Atrx
T7905	3093-3098	NCBITaxon:9606	denotes	human
T7906	3103-3104	GO:0000805	denotes	X
T7907	3147-3151	PR:000004503	denotes	Atrx
T7908	3159-3170	UBERON:0000088	denotes	trophoblast
T7909	3186-3190	NCBITaxon:10088	denotes	mice
T7910	3200-3204	PR:000004503	denotes	ATRX
T7911	3240-3245	NCBITaxon:9606	denotes	human
T7912	3246-3257	UBERON:0000088	denotes	trophoblast
T7913	3271-3276	GO:0007567	denotes	birth
T7914	3303-3304	GO:0000805	denotes	X
T7915	3413-3417	NCBITaxon:10088	denotes	mice
T7916	3430-3434	PR:000004503	denotes	Atrx
T7917	3514-3518	PR:000004503	denotes	Atrx
T7918	3600-3605	NCBITaxon:9606	denotes	human
T7919	3610-3611	GO:0000805	denotes	X
T7920	3657-3664	SO:0001023	denotes	alleles
T7921	3683-3687	PR:000004503	denotes	ATRX
T7922	3813-3817	PR:000004503	denotes	ATRX
T7923	3856-3874	NCBITaxon:10376	denotes	Epstein-Barr virus
T7924	3875-3886	GO:0009294	denotes	transformed
T7925	3887-3898	CL:0000542	denotes	lymphocytes
T7926	3906-3911	NCBITaxon:9606	denotes	human
T7927	4022-4026	PR:000004503	denotes	ATRX
T7928	4027-4033	SO:0001023	denotes	allele
T7929	4040-4045	NCBITaxon:9606	denotes	human
T7930	4089-4094	NCBITaxon:10088	denotes	mouse
T7931	4120-4124	PR:000004503	denotes	ATRX
T7932	4154-4159	NCBITaxon:9606	denotes	human
T7933	4229-4233	PR:000004503	denotes	Atrx
T7934	4241-4247	NCBITaxon:39107	denotes	murine
T7935	4248-4261	UBERON:0004345	denotes	trophectoderm
T7936	4310-4314	PR:000004503	denotes	Atrx
T7937	4319-4326	UBERON:0000922	denotes	embryos
T7938	4374-4378	PR:000004503	denotes	Atrx
T7939	4412-4419	UBERON:0000479	denotes	tissues
T7940	4427-4433	UBERON:0000922	denotes	embryo
T7941	4463-4467	PR:000004503	denotes	Atrx
T7942	4478-4487	GO:0010467	denotes	expressed
T7943	4521-4527	UBERON:0000922	denotes	embryo
T7944	4574-4578	PR:000004503	denotes	Atrx
T7945	4644-4651	UBERON:0000479	denotes	tissues
T7946	4705-4712	UBERON:0000922	denotes	embryos
T7947	4740-4762	UBERON:0005292	denotes	extraembryonic tissues
T7948	4801-4805	PR:000004503	denotes	Atrx
T7949	4819-4824	NCBITaxon:10088	denotes	mouse
T7950	4913-4917	PR:000004503	denotes	Atrx
T7951	4918-4922	SO:0000359	denotes	flox
T7952	4923-4929	SO:0001023	denotes	allele
T7953	4968-4974	UBERON:0000479	denotes	tissue
T7954	4988-4998	SO:0000902	denotes	transgenes
T7955	5075-5079	PR:000004503	denotes	Atrx
T7956	5087-5095	CL:0000540	denotes	neuronal
T7957	5115-5120	UBERON:0007023	denotes	adult
T7958	5121-5125	NCBITaxon:10088	denotes	mice
T7959	5154-5158	PR:000004503	denotes	Atrx
T7960	5195-5200	NCBITaxon:10088	denotes	mouse
T7961	5266-5270	PR:000004503	denotes	Atrx
T7962	5302-5309	UBERON:0000479	denotes	tissues
T7963	5328-5332	NCBITaxon:10088	denotes	mice
T7964	5340-5347	UBERON:0000479	denotes	tissues
T7965	5379-5383	PR:000004503	denotes	Atrx
T7966	5397-5401	PR:000004503	denotes	Atrx
T7967	5439-5440	GO:0000805	denotes	X
T7968	5439-5453	GO:0009048	denotes	X-inactivation
T7969	5490-5494	PR:000004503	denotes	Atrx
T7970	5522-5527	NCBITaxon:10088	denotes	mouse
T7971	5528-5533	SO:0000704	denotes	genes
T7972	5580-5592	GO:0007566	denotes	implantation
T7973	5618-5629	UBERON:0000088	denotes	trophoblast
T7974	5633-5642	UBERON:0001987	denotes	placental
T7975	5754-5758	PR:000004503	denotes	Atrx
T7976	5762-5773	UBERON:0000088	denotes	trophoblast
T7977	5787-5791	PR:000004503	denotes	Atrx
T7978	5799-5806	UBERON:0000922	denotes	embryos
T7979	5829-5836	UBERON:0000922	denotes	embryos
T7980	5885-5901	_FRAGMENT	denotes	specification of
T7981	5914-5924	GO:0048866	denotes	stem cells
T7982	5902-5913	UBERON:0000088	denotes	trophoblast
T7983	5902-5913	_FRAGMENT	denotes	trophoblast
T7984	5919-5924	CL:0000351	denotes	cells
T7985	5914-5924	CL:0000034	denotes	stem cells
T7986	5934-5938	PR:000005296	denotes	Cdx2
T7987	5946-5955	CL:0000034	denotes	stem cell
T7988	5946-5967	GO:0019827	denotes	stem cell maintenance
T7989	5946-5955	_FRAGMENT	denotes	stem cell
T7990	5972-5985	GO:0072089	denotes	proliferation
T7991	5995-6000	PR:000003463	denotes	Eomes
T7992	6003-6007	PR:000005296	denotes	Cdx2
T7993	6015-6022	UBERON:0000922	denotes	embryos
T7994	6031-6038	GO:0007566	denotes	implant
T7995	6043-6046	GO:0016265	denotes	die
T7996	6083-6088	PR:000003463	denotes	Eomes
T7997	6096-6107	UBERON:0000358	denotes	blastocysts
T7998	6108-6115	GO:0007566	denotes	implant
T7999	6125-6131	UBERON:0000995	denotes	uterus
T8000	6155-6167	GO:0007566	denotes	implantation
T8001	6194-6203	_FRAGMENT	denotes	embryonic
T8002	6222-6232	UBERON:0002050	denotes	structures
T8003	6207-6232	UBERON:0000478	denotes	extraembryonic structures
T8004	6252-6256	PR:000004503	denotes	Atrx
T8005	6264-6271	UBERON:0000922	denotes	embryos
T8006	6272-6279	GO:0007566	denotes	implant
T8007	6317-6337	UBERON:0002050	denotes	embryonic structures
T8008	6354-6358	PR:000004503	denotes	Atrx
T8009	6411-6415	NCBITaxon:10088	denotes	mice
T8010	6436-6441	CHEBI:22695	denotes	basic
T8011	6442-6447	SO:0001114	denotes	helix
T8012	6453-6458	SO:0001114	denotes	helix
T8013	6480-6485	PR:000008439	denotes	Hand1
T8014	6487-6492	PR:000008439	denotes	Hand1
T8015	6558-6567	UBERON:0000922	denotes	embryonic
T8016	6591-6595	PR:000004503	denotes	Atrx
T8017	6603-6610	UBERON:0000922	denotes	embryos
T8018	6624-6629	PR:000008439	denotes	Hand1
T8019	6668-6686	UBERON:0004364	denotes	ectoplacental cone
T8020	6702-6706	CL:0002488	denotes	TGCs
T8021	6721-6725	PR:000004503	denotes	Atrx
T8022	6761-6766	PR:000008439	denotes	Hand1
T8023	6774-6785	UBERON:0004716	denotes	conceptuses
T8024	6826-6830	PR:000004503	denotes	Atrx
T8025	6846-6851	PR:000008439	denotes	Hand1
T8026	6873-6893	CL:0002498	denotes	secondary giant cell
T8027	6889-6903	GO:0048468	denotes	cell formation
T8028	6917-6928	UBERON:0000088	denotes	trophoblast
T8029	6945-6956	UBERON:0000358	denotes	blastocysts
T8030	6974-6979	PR:000008439	denotes	Hand1
T8031	7024-7038	CL:0002498	denotes	secondary TGCs
T8032	7059-7070	UBERON:0000088	denotes	trophoblast
T8033	7059-7076	CL:0000351	denotes	trophoblast cells
T8034	7112-7130	UBERON:0004364	denotes	ectoplacental cone
T8035	7168-7172	PR:000004503	denotes	Atrx
T8036	7178-7183	PR:000008439	denotes	Hand1
T8037	7226-7230	PR:000004503	denotes	Atrx
T8038	7280-7289	GO:0000785	denotes	chromatin
T8039	7345-7349	PR:000004503	denotes	Atrx
T8040	7375-7380	PR:000008439	denotes	Hand1
T8041	7381-7391	GO:0010467	denotes	expression
T8042	7504-7509	PR:000008439	denotes	Hand1
T8043	7541-7546	UBERON:0000955	denotes	brain
T8044	7556-7560	PR:000004503	denotes	Atrx
T8045	7570-7574	NCBITaxon:10088	denotes	mice
T8046	7630-7637	CL:0000540	denotes	neurons
T8047	7648-7662	CL:0002498	denotes	secondary TGCs
T8048	7689-7693	PR:000004503	denotes	Atrx
T8049	7770-7777	UBERON:0000479	denotes	tissues
T8050	7796-7801	NCBITaxon:10088	denotes	mouse
T8051	7845-7849	PR:000004503	denotes	Atrx
T8052	7868-7878	GO:0010467	denotes	expression
T8053	7887-7893	UBERON:0000479	denotes	tissue
T8054	7903-7908	SO:0000704	denotes	genes
T8055	7974-7980	CHEBI:5386	denotes	globin
T8056	7981-7986	SO:0000704	denotes	genes
T8057	8034-8044	GO:0065007	denotes	regulation
T8058	8048-8053	NCBITaxon:9606	denotes	human
T8059	8054-8058	PR:000004503	denotes	ATRX
T8060	8076-8085	GO:0010467	denotes	expressed
T8061	8142-8151	CL:0000764	denotes	erythroid
T9596	8162-8166	PR:000004503	denotes	Atrx
T9597	8175-8199	GO:0060819	denotes	Imprinted X-Inactivation
T9598	8185-8186	GO:0000805	denotes	X
T9599	8203-8225	UBERON:0005292	denotes	Extraembryonic Tissues
T9600	8244-8248	NCBITaxon:10088	denotes	Mice
T9601	8317-8324	UBERON:0000922	denotes	embryos
T9602	8349-8353	PR:000004503	denotes	Atrx
T9603	8357-8363	SO:0001023	denotes	allele
T9604	8397-8421	GO:0060819	denotes	imprinted X-inactivation
T9605	8407-8408	GO:0000805	denotes	X
T9606	8440-8448	GO:0016458	denotes	silences
T9607	8479-8488	UBERON:0000922	denotes	embryonic
T9608	8511-8517	NCBITaxon:39107	denotes	murine
T9609	8518-8525	UBERON:0000479	denotes	tissues
T9610	8532-8541	GO:0016458	denotes	Silencing
T9611	8549-8553	PR:000004503	denotes	Atrx
T9612	8557-8563	SO:0001023	denotes	allele
T9613	8607-8611	PR:000004503	denotes	Atrx
T9614	8619-8641	UBERON:0005292	denotes	extraembryonic tissues
T9615	8695-8699	PR:000004503	denotes	Atrx
T9616	8708-8714	SO:0001023	denotes	allele
T9617	8757-8761	PR:000004503	denotes	Atrx
T9618	8811-8820	GO:0000003	denotes	reproduce
T9619	8853-8860	GO:0016458	denotes	silence
T9620	8884-8888	PR:000007899	denotes	Atrx
T9621	8892-8898	SO:0001023	denotes	allele
T9622	8906-8928	UBERON:0005292	denotes	extraembryonic tissues
T9623	8992-8996	PR:000007899	denotes	Atrx
T9624	9012-9016	PR:000004503	denotes	Atrx
T9625	9075-9086	UBERON:0000088	denotes	trophoblast
T9626	9133-9138	NCBITaxon:10088	denotes	mouse
T9627	9156-9160	PR:000004503	denotes	Atrx
T9628	9246-9252	NCBITaxon:39107	denotes	murine
T9629	9253-9254	GO:0000805	denotes	X
T9630	9262-9267	SO:0000704	denotes	genes
T9631	9302-9311	UBERON:0000922	denotes	embryonic
T9632	9365-9373	PR:000006498	denotes	dyskerin
T9633	9375-9379	PR:000006498	denotes	Dkc1
T9634	9382-9401	CHEBI:14314	denotes	glucose 6-phosphate
T9635	9428-9441	PR:000005430	denotes	choroideremia
T9636	9443-9446	PR:000005430	denotes	Chm
T9637	9448-9453	SO:0000704	denotes	genes
T9638	9460-9469	UBERON:0000922	denotes	embryonic
T9639	9493-9500	UBERON:0000922	denotes	embryos
T9640	9529-9538	UBERON:0000922	denotes	embryonic
T9641	9547-9554	UBERON:0000479	denotes	tissues
T9642	9571-9575	NCBITaxon:10088	denotes	mice
T9643	9604-9609	SO:0000704	denotes	genes
T9644	9638-9650	GO:0000805	denotes	X chromosome
T9645	9656-9659	GO:0016265	denotes	die
T9646	9755-9759	PR:000004503	denotes	Atrx
T9647	9767-9772	SO:0000704	denotes	genes
T9648	9887-9909	UBERON:0005292	denotes	extraembryonic tissues
T9649	9913-9920	GO:0010467	denotes	express
T9650	9949-9961	GO:0000805	denotes	X chromosome
T9651	9973-9983	GO:0010467	denotes	expression
T9652	10000-10004	PR:000004503	denotes	Atrx
T9653	10008-10014	SO:0001023	denotes	allele
T9654	10036-10058	UBERON:0005292	denotes	extraembryonic tissues
T9655	10066-10070	PR:000004503	denotes	Atrx
T9656	10129-10130	GO:0000805	denotes	X
T9657	10138-10143	SO:0000704	denotes	genes
T9658	10145-10157	_FRAGMENT	denotes	silencing of
T9659	10167-10171	GO:0016458	denotes	gene
T9660	10162-10166	PR:000004503	denotes	Atrx
T9661	10167-10171	SO:0000704	denotes	gene
T9662	10248-10252	PR:000004503	denotes	Atrx
T9663	10298-10320	UBERON:0005292	denotes	extraembryonic tissues
T9664	10378-10382	PR:000004503	denotes	Atrx
T9665	10396-10402	SO:0001023	denotes	allele
T9666	10417-10425	GO:0016458	denotes	silenced
T9667	10438-10443	NCBITaxon:10088	denotes	mouse
T9668	10444-10455	UBERON:0000088	denotes	trophoblast
T9669	10444-10455	_FRAGMENT	denotes	trophoblast
T9670	10461-10465	CL:0000351	denotes	cell
T9671	10456-10465	CL:0000034	denotes	stem cell
T9672	10493-10497	PR:000004503	denotes	Atrx
T9673	10523-10547	GO:0060819	denotes	imprinted X-inactivation
T9674	10533-10534	GO:0000805	denotes	X
T9675	10555-10577	UBERON:0005292	denotes	extraembryonic tissues
T9676	10610-10620	GO:0010467	denotes	expression
T9677	10638-10642	PR:000004503	denotes	Atrx
T9678	10646-10652	SO:0001023	denotes	allele
T9679	10706-10710	PR:000004503	denotes	Atrx
T9680	10716-10722	SO:0001023	denotes	allele
T9681	10831-10855	GO:0060819	denotes	imprinted X-inactivation
T9682	10841-10842	GO:0000805	denotes	X
T9683	10896-10901	NCBITaxon:10088	denotes	mouse
T9684	10902-10924	UBERON:0005292	denotes	extraembryonic tissues
T9685	11011-11023	GO:0000805	denotes	X chromosome
T9686	11234-11244	GO:0010467	denotes	expression
T9687	11271-11272	GO:0000805	denotes	X
T9688	11280-11284	PR:000033987	denotes	lacZ
T9689	11306-11316	SO:0000902	denotes	transgenes
T9690	11330-11338	GO:0016458	denotes	silenced
T9691	11367-11387	CL:0000349	denotes	extraembryonic cells
T9692	11372-11381	UBERON:0000922	denotes	embryonic
T9693	11443-11463	CL:0000349	denotes	extraembryonic cells
T9694	11448-11457	UBERON:0000922	denotes	embryonic
T9695	11517-11528	GO:0006260	denotes	replication
T9696	11638-11645	UBERON:0000922	denotes	embryos
T9697	11754-11763	GO:0071514	denotes	imprinted
T9698	11778-11787	UBERON:0000922	denotes	embryonic
T9699	11811-11820	GO:0016458	denotes	silencing
T9700	11839-11843	_FRAGMENT	denotes	cell
T9701	11854-11869	GO:0030154	denotes	differentiation
T9702	11963-11973	GO:0071514	denotes	imprinting
T9703	12022-12033	SO:0000704	denotes	genetically
T9704	12044-12051	UBERON:0000922	denotes	embryos
T9705	12154-12161	SO:0001023	denotes	alleles
T9706	12165-12170	SO:0000704	denotes	genes
T9707	12197-12206	UBERON:0000922	denotes	embryonic
T9708	12457-12461	PR:000004503	denotes	Atrx
T9709	12498-12503	GO:0016265	denotes	dying
T9710	12600-12615	_FRAGMENT	denotes	inactivation of
T9711	12620-12630	GO:0060817	denotes	paternal X
T9712	12629-12630	GO:0000805	denotes	X
T9713	12684-12688	PR:000004503	denotes	Atrx
T9714	12689-12693	SO:0000704	denotes	gene
T9715	12767-12771	PR:000004503	denotes	Atrx
T9716	12786-12792	SO:0001023	denotes	allele
T9717	12836-12845	GO:0016458	denotes	silencing
T9718	12877-12882	SO:0000704	denotes	genes
T9719	12899-12911	GO:0000805	denotes	X chromosome
T9720	12962-12977	_FRAGMENT	denotes	inactivation of
T9721	12989-13002	GO:0060817	denotes	Xp chromosome
T9722	13010-13019	UBERON:0000922	denotes	embryonic
T9723	13039-13046	SO:0001023	denotes	allelic
T9724	13047-13057	GO:0010467	denotes	expression
T9725	13061-13062	GO:0000805	denotes	X
T9726	13070-13075	SO:0000704	denotes	genes
T9727	13083-13094	UBERON:0000088	denotes	trophoblast
T10873	13795-13801	NCBITaxon:33208	denotes	animal
T10874	13825-13829	PR:000004503	denotes	Atrx
T10875	13830-13834	SO:0000704	denotes	gene
T10876	13851-13860	UBERON:0000922	denotes	embryonic
T10877	13911-13915	PR:000004503	denotes	Atrx
T10878	13940-13946	NCBITaxon:39107	denotes	murine
T10879	13947-13958	UBERON:0000088	denotes	trophoblast
T10880	13973-13977	PR:000004503	denotes	Atrx
T10881	13996-14031	GO:0060819	denotes	imprinted X-chromosome inactivation
T10882	14006-14018	GO:0000805	denotes	X-chromosome
T10883	14039-14061	UBERON:0005292	denotes	extraembryonic tissues
T10884	14085-14089	NCBITaxon:10088	denotes	mice
T7177	43-47	PR:000004503	denotes	Atrx
T7178	59-64	NCBITaxon:10088	denotes	mouse
T7179	147-151	PR:000004503	denotes	Atrx
T7180	169-177	CL:0002322	denotes	ES cells
T7181	182-197	UBERON:0014374	denotes	embryoid bodies
T7182	222-227	NCBITaxon:10088	denotes	mouse
T7183	228-235	UBERON:0000922	denotes	embryos
T10854	13114-13115	GO:0000805	denotes	X
T10855	13138-13143	NCBITaxon:9606	denotes	human
T10856	13144-13151	SO:0000704	denotes	genetic
T10857	13197-13206	GO:0000785	denotes	chromatin
T10858	13197-13218	GO:0006338	denotes	chromatin remodelling
T10859	13257-13261	PR:000004503	denotes	ATRX
T10860	13273-13277	SO:0000704	denotes	gene
T10861	13273-13288	GO:0010467	denotes	gene expression
T10862	13416-13417	GO:0000805	denotes	X
T10863	13545-13549	PR:000004503	denotes	Atrx
T10864	13568-13573	NCBITaxon:10088	denotes	mouse
T10865	13574-13583	UBERON:0001890	denotes	forebrain
T10866	13598-13602	PR:000004503	denotes	Atrx
T10867	13603-13607	SO:0000359	denotes	flox
T10868	13608-13614	SO:0001023	denotes	allele
T10869	13642-13646	PR:000004503	denotes	Atrx
T10870	13699-13706	CL:0000540	denotes	neurons
T10871	13736-13740	PR:000004503	denotes	Atrx
T10872	13750-13757	UBERON:0000479	denotes	tissues
R4817	T7990	T7989	_lexicallyChainedTo	proliferation,stem cell
R4818	T8002	T8001	_lexicallyChainedTo	structures,embryonic
R5913	T9659	T9658	_lexicallyChainedTo	gene,silencing of
R5914	T9670	T9669	_lexicallyChainedTo	cell,trophoblast
R5915	T9701	T9700	_lexicallyChainedTo	differentiation,cell
R5916	T9711	T9710	_lexicallyChainedTo	paternal X,inactivation of
R5917	T9721	T9720	_lexicallyChainedTo	Xp chromosome,inactivation of
R4814	T7885	T7884	_lexicallyChainedTo	cell,diploid
R4815	T7981	T7980	_lexicallyChainedTo	stem cells,specification of
R4816	T7984	T7983	_lexicallyChainedTo	cells,trophoblast

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PMC:1440874 / 35970-50060 JSON TXT