Id |
Subject |
Object |
Predicate |
Lexical cue |
T2767 |
0-2 |
TO |
denotes |
To |
T2768 |
3-14 |
VB |
denotes |
investigate |
T2769 |
71-79 |
VBD |
denotes |
analysed |
T2770 |
15-16 |
DT |
denotes |
a |
T2771 |
37-43 |
NN |
denotes |
defect |
T2772 |
17-25 |
JJ |
denotes |
possible |
T2773 |
26-30 |
NN |
denotes |
cell |
T2774 |
31-36 |
NN |
denotes |
cycle |
T2775 |
30-31 |
HYPH |
denotes |
- |
T2776 |
44-46 |
IN |
denotes |
in |
T2777 |
47-50 |
DT |
denotes |
the |
T2778 |
51-58 |
NN |
denotes |
absence |
T2779 |
59-61 |
IN |
denotes |
of |
T2780 |
62-66 |
NN |
denotes |
Atrx |
T2781 |
66-68 |
, |
denotes |
, |
T2782 |
68-70 |
PRP |
denotes |
we |
T2783 |
80-83 |
DT |
denotes |
the |
T2784 |
95-107 |
NN |
denotes |
distribution |
T2785 |
84-88 |
NN |
denotes |
cell |
T2786 |
89-94 |
NN |
denotes |
cycle |
T2787 |
108-110 |
IN |
denotes |
of |
T2788 |
111-128 |
NN |
denotes |
bromodeoxyuridine |
T2789 |
136-142 |
VBN |
denotes |
pulsed |
T2790 |
129-130 |
-LRB- |
denotes |
( |
T2791 |
130-134 |
NN |
denotes |
BrdU |
T2792 |
134-135 |
-RRB- |
denotes |
) |
T2793 |
135-136 |
HYPH |
denotes |
- |
T2794 |
146-151 |
NNS |
denotes |
cells |
T2795 |
143-145 |
NN |
denotes |
ES |
T2796 |
152-154 |
IN |
denotes |
by |
T2797 |
155-159 |
NN |
denotes |
flow |
T2798 |
160-169 |
NN |
denotes |
cytometry |
T2799 |
170-171 |
-LRB- |
denotes |
( |
T2800 |
178-181 |
NN |
denotes |
S1A |
T2801 |
171-177 |
NN |
denotes |
Figure |
T2802 |
181-182 |
-RRB- |
denotes |
) |
T2803 |
182-183 |
. |
denotes |
. |
T2804 |
183-355 |
sentence |
denotes |
Surprisingly, both Atrxnull ES cell clones exhibited a cell cycle profile that was indistinguishable from ES cells bearing a functional Atrx allele (Atrx WT or Atrx flox). |
T2805 |
184-196 |
RB |
denotes |
Surprisingly |
T2806 |
227-236 |
VBD |
denotes |
exhibited |
T2807 |
196-198 |
, |
denotes |
, |
T2808 |
198-202 |
DT |
denotes |
both |
T2809 |
220-226 |
NNS |
denotes |
clones |
T2810 |
203-211 |
JJ |
denotes |
Atrxnull |
T2811 |
215-219 |
NN |
denotes |
cell |
T2812 |
212-214 |
NN |
denotes |
ES |
T2813 |
237-238 |
DT |
denotes |
a |
T2814 |
250-257 |
NN |
denotes |
profile |
T2815 |
239-243 |
NN |
denotes |
cell |
T2816 |
244-249 |
NN |
denotes |
cycle |
T2817 |
258-262 |
WDT |
denotes |
that |
T2818 |
263-266 |
VBD |
denotes |
was |
T2819 |
267-284 |
JJ |
denotes |
indistinguishable |
T2820 |
285-289 |
IN |
denotes |
from |
T2821 |
290-292 |
NN |
denotes |
ES |
T2822 |
293-298 |
NNS |
denotes |
cells |
T2823 |
299-306 |
VBG |
denotes |
bearing |
T2824 |
307-308 |
DT |
denotes |
a |
T2825 |
325-331 |
NN |
denotes |
allele |
T2826 |
309-319 |
JJ |
denotes |
functional |
T2827 |
320-324 |
NN |
denotes |
Atrx |
T2828 |
332-333 |
-LRB- |
denotes |
( |
T2829 |
333-340 |
NN |
denotes |
Atrx WT |
T2830 |
341-343 |
CC |
denotes |
or |
T2831 |
344-353 |
NN |
denotes |
Atrx flox |
T2832 |
353-354 |
-RRB- |
denotes |
) |
T2833 |
354-355 |
. |
denotes |
. |
T2834 |
355-558 |
sentence |
denotes |
We also specifically quantitated the mitotic index within each population by flow cytometry after staining ES cells for phosphorylated (Ser10) histone H3, a specific marker of mitosis (Figure S1B) [13]. |
T2835 |
356-358 |
PRP |
denotes |
We |
T2836 |
377-388 |
VBD |
denotes |
quantitated |
T2837 |
359-363 |
RB |
denotes |
also |
T2838 |
364-376 |
RB |
denotes |
specifically |
T2839 |
389-392 |
DT |
denotes |
the |
T2840 |
401-406 |
NN |
denotes |
index |
T2841 |
393-400 |
JJ |
denotes |
mitotic |
T2842 |
407-413 |
IN |
denotes |
within |
T2843 |
414-418 |
DT |
denotes |
each |
T2844 |
419-429 |
NN |
denotes |
population |
T2845 |
430-432 |
IN |
denotes |
by |
T2846 |
433-437 |
NN |
denotes |
flow |
T2847 |
438-447 |
NN |
denotes |
cytometry |
T2848 |
448-453 |
IN |
denotes |
after |
T2849 |
454-462 |
VBG |
denotes |
staining |
T2850 |
463-465 |
NN |
denotes |
ES |
T2851 |
466-471 |
NNS |
denotes |
cells |
T2852 |
472-475 |
IN |
denotes |
for |
T2853 |
476-490 |
VBN |
denotes |
phosphorylated |
T2854 |
507-509 |
NN |
denotes |
H3 |
T2855 |
491-492 |
-LRB- |
denotes |
( |
T2856 |
492-497 |
NN |
denotes |
Ser10 |
T2857 |
497-498 |
-RRB- |
denotes |
) |
T2858 |
499-506 |
NN |
denotes |
histone |
T2859 |
509-511 |
, |
denotes |
, |
T2860 |
511-512 |
DT |
denotes |
a |
T2861 |
522-528 |
NN |
denotes |
marker |
T2862 |
513-521 |
JJ |
denotes |
specific |
T2863 |
529-531 |
IN |
denotes |
of |
T2864 |
532-539 |
NN |
denotes |
mitosis |
T2865 |
540-541 |
-LRB- |
denotes |
( |
T2866 |
548-551 |
NN |
denotes |
S1B |
T2867 |
541-547 |
NN |
denotes |
Figure |
T2868 |
551-552 |
-RRB- |
denotes |
) |
T2869 |
553-554 |
-LRB- |
denotes |
[ |
T2870 |
554-556 |
CD |
denotes |
13 |
T2871 |
556-557 |
-RRB- |
denotes |
] |
T2872 |
557-558 |
. |
denotes |
. |
T2873 |
558-735 |
sentence |
denotes |
Consistent with the normal cell-cycle profile observed above, there was no depletion in the size of the mitotic population in the Atrxnull ES clones, despite their slow growth. |
T2874 |
559-569 |
JJ |
denotes |
Consistent |
T2875 |
627-630 |
VBD |
denotes |
was |
T2876 |
570-574 |
IN |
denotes |
with |
T2877 |
575-578 |
DT |
denotes |
the |
T2878 |
597-604 |
NN |
denotes |
profile |
T2879 |
579-585 |
JJ |
denotes |
normal |
T2880 |
586-590 |
NN |
denotes |
cell |
T2881 |
591-596 |
NN |
denotes |
cycle |
T2882 |
590-591 |
HYPH |
denotes |
- |
T2883 |
605-613 |
VBN |
denotes |
observed |
T2884 |
614-619 |
RB |
denotes |
above |
T2885 |
619-621 |
, |
denotes |
, |
T2886 |
621-626 |
EX |
denotes |
there |
T2887 |
631-633 |
DT |
denotes |
no |
T2888 |
634-643 |
NN |
denotes |
depletion |
T2889 |
644-646 |
IN |
denotes |
in |
T2890 |
647-650 |
DT |
denotes |
the |
T2891 |
651-655 |
NN |
denotes |
size |
T2892 |
656-658 |
IN |
denotes |
of |
T2893 |
659-662 |
DT |
denotes |
the |
T2894 |
671-681 |
NN |
denotes |
population |
T2895 |
663-670 |
JJ |
denotes |
mitotic |
T2896 |
682-684 |
IN |
denotes |
in |
T2897 |
685-688 |
DT |
denotes |
the |
T2898 |
701-707 |
NNS |
denotes |
clones |
T2899 |
689-697 |
JJ |
denotes |
Atrxnull |
T2900 |
698-700 |
NN |
denotes |
ES |
T2901 |
707-709 |
, |
denotes |
, |
T2902 |
709-716 |
IN |
denotes |
despite |
T2903 |
717-722 |
PRP$ |
denotes |
their |
T2904 |
728-734 |
NN |
denotes |
growth |
T2905 |
723-727 |
JJ |
denotes |
slow |
T2906 |
734-735 |
. |
denotes |
. |
T2907 |
735-1013 |
sentence |
denotes |
Finally, we investigated whether the growth defect in the Atrxnull ES cells was due to an up-regulation of apoptosis by staining cells with Annexin V (Figure S2) and found that the proportion of apoptotic cells was not significantly affected by the absence of full-length Atrx. |
T2908 |
736-743 |
RB |
denotes |
Finally |
T2909 |
748-760 |
VBD |
denotes |
investigated |
T2910 |
743-745 |
, |
denotes |
, |
T2911 |
745-747 |
PRP |
denotes |
we |
T2912 |
761-768 |
IN |
denotes |
whether |
T2913 |
812-815 |
VBD |
denotes |
was |
T2914 |
769-772 |
DT |
denotes |
the |
T2915 |
780-786 |
NN |
denotes |
defect |
T2916 |
773-779 |
NN |
denotes |
growth |
T2917 |
787-789 |
IN |
denotes |
in |
T2918 |
790-793 |
DT |
denotes |
the |
T2919 |
806-811 |
NNS |
denotes |
cells |
T2920 |
794-802 |
JJ |
denotes |
Atrxnull |
T2921 |
803-805 |
NN |
denotes |
ES |
T2922 |
816-819 |
IN |
denotes |
due |
T2923 |
820-822 |
IN |
denotes |
to |
T2924 |
823-825 |
DT |
denotes |
an |
T2925 |
829-839 |
NN |
denotes |
regulation |
T2926 |
826-828 |
JJ |
denotes |
up |
T2927 |
828-829 |
HYPH |
denotes |
- |
T2928 |
840-842 |
IN |
denotes |
of |
T2929 |
843-852 |
NN |
denotes |
apoptosis |
T2930 |
853-855 |
IN |
denotes |
by |
T2931 |
856-864 |
VBG |
denotes |
staining |
T2932 |
865-870 |
NNS |
denotes |
cells |
T2933 |
871-875 |
IN |
denotes |
with |
T2934 |
876-883 |
NN |
denotes |
Annexin |
T2935 |
884-885 |
CD |
denotes |
V |
T2936 |
886-887 |
-LRB- |
denotes |
( |
T2937 |
894-896 |
NN |
denotes |
S2 |
T2938 |
887-893 |
NN |
denotes |
Figure |
T2939 |
896-897 |
-RRB- |
denotes |
) |
T2940 |
898-901 |
CC |
denotes |
and |
T2941 |
902-907 |
VBD |
denotes |
found |
T2942 |
908-912 |
IN |
denotes |
that |
T2943 |
969-977 |
VBN |
denotes |
affected |
T2944 |
913-916 |
DT |
denotes |
the |
T2945 |
917-927 |
NN |
denotes |
proportion |
T2946 |
928-930 |
IN |
denotes |
of |
T2947 |
931-940 |
JJ |
denotes |
apoptotic |
T2948 |
941-946 |
NNS |
denotes |
cells |
T2949 |
947-950 |
VBD |
denotes |
was |
T2950 |
951-954 |
RB |
denotes |
not |
T2951 |
955-968 |
RB |
denotes |
significantly |
T2952 |
978-980 |
IN |
denotes |
by |
T2953 |
981-984 |
DT |
denotes |
the |
T2954 |
985-992 |
NN |
denotes |
absence |
T2955 |
993-995 |
IN |
denotes |
of |
T2956 |
996-1000 |
JJ |
denotes |
full |
T2957 |
1001-1007 |
NN |
denotes |
length |
T2958 |
1000-1001 |
HYPH |
denotes |
- |
T2959 |
1008-1012 |
NN |
denotes |
Atrx |
T2960 |
1012-1013 |
. |
denotes |
. |
T2961 |
1013-1153 |
sentence |
denotes |
Thus, the growth defect observed in ES cells lacking Atrx is not due to a specific cell cycle block or significant induction of cell death. |
T2962 |
1014-1018 |
RB |
denotes |
Thus |
T2963 |
1072-1074 |
VBZ |
denotes |
is |
T2964 |
1018-1020 |
, |
denotes |
, |
T2965 |
1020-1023 |
DT |
denotes |
the |
T2966 |
1031-1037 |
NN |
denotes |
defect |
T2967 |
1024-1030 |
NN |
denotes |
growth |
T2968 |
1038-1046 |
VBN |
denotes |
observed |
T2969 |
1047-1049 |
IN |
denotes |
in |
T2970 |
1050-1052 |
NN |
denotes |
ES |
T2971 |
1053-1058 |
NNS |
denotes |
cells |
T2972 |
1059-1066 |
VBG |
denotes |
lacking |
T2973 |
1067-1071 |
NN |
denotes |
Atrx |
T2974 |
1075-1078 |
RB |
denotes |
not |
T2975 |
1079-1082 |
IN |
denotes |
due |
T2976 |
1083-1085 |
IN |
denotes |
to |
T2977 |
1086-1087 |
DT |
denotes |
a |
T2978 |
1108-1113 |
NN |
denotes |
block |
T2979 |
1088-1096 |
JJ |
denotes |
specific |
T2980 |
1097-1101 |
NN |
denotes |
cell |
T2981 |
1102-1107 |
NN |
denotes |
cycle |
T2982 |
1114-1116 |
CC |
denotes |
or |
T2983 |
1117-1128 |
JJ |
denotes |
significant |
T2984 |
1129-1138 |
NN |
denotes |
induction |
T2985 |
1139-1141 |
IN |
denotes |
of |
T2986 |
1142-1146 |
NN |
denotes |
cell |
T2987 |
1147-1152 |
NN |
denotes |
death |
T2988 |
1152-1153 |
. |
denotes |
. |
T2989 |
1153-1520 |
sentence |
denotes |
While the cause of the proliferative delay is not yet clear, since Atrxnull ES cells appear to undergo higher rates of spontaneous differentiation (unpublished data), it seems likely that the observed growth defect reflects the spontaneous transition from fast-cycling, undifferentiated ES cells into more slowly cycling, differentiated cell types in these cultures. |
T2990 |
1154-1159 |
IN |
denotes |
While |
T2991 |
1197-1199 |
VBZ |
denotes |
is |
T2992 |
1160-1163 |
DT |
denotes |
the |
T2993 |
1164-1169 |
NN |
denotes |
cause |
T2994 |
1170-1172 |
IN |
denotes |
of |
T2995 |
1173-1176 |
DT |
denotes |
the |
T2996 |
1191-1196 |
NN |
denotes |
delay |
T2997 |
1177-1190 |
JJ |
denotes |
proliferative |
T2998 |
1324-1329 |
VBZ |
denotes |
seems |
T2999 |
1200-1203 |
RB |
denotes |
not |
T3000 |
1204-1207 |
RB |
denotes |
yet |
T3001 |
1208-1213 |
JJ |
denotes |
clear |
T3002 |
1213-1215 |
, |
denotes |
, |
T3003 |
1215-1220 |
IN |
denotes |
since |
T3004 |
1239-1245 |
VBP |
denotes |
appear |
T3005 |
1221-1229 |
JJ |
denotes |
Atrxnull |
T3006 |
1233-1238 |
NNS |
denotes |
cells |
T3007 |
1230-1232 |
NN |
denotes |
ES |
T3008 |
1246-1248 |
TO |
denotes |
to |
T3009 |
1249-1256 |
VB |
denotes |
undergo |
T3010 |
1257-1263 |
JJR |
denotes |
higher |
T3011 |
1264-1269 |
NNS |
denotes |
rates |
T3012 |
1270-1272 |
IN |
denotes |
of |
T3013 |
1273-1284 |
JJ |
denotes |
spontaneous |
T3014 |
1285-1300 |
NN |
denotes |
differentiation |
T3015 |
1301-1302 |
-LRB- |
denotes |
( |
T3016 |
1314-1318 |
NNS |
denotes |
data |
T3017 |
1302-1313 |
JJ |
denotes |
unpublished |
T3018 |
1318-1319 |
-RRB- |
denotes |
) |
T3019 |
1319-1321 |
, |
denotes |
, |
T3020 |
1321-1323 |
PRP |
denotes |
it |
T3021 |
1330-1336 |
JJ |
denotes |
likely |
T3022 |
1337-1341 |
IN |
denotes |
that |
T3023 |
1369-1377 |
VBZ |
denotes |
reflects |
T3024 |
1342-1345 |
DT |
denotes |
the |
T3025 |
1362-1368 |
NN |
denotes |
defect |
T3026 |
1346-1354 |
VBN |
denotes |
observed |
T3027 |
1355-1361 |
NN |
denotes |
growth |
T3028 |
1378-1381 |
DT |
denotes |
the |
T3029 |
1394-1404 |
NN |
denotes |
transition |
T3030 |
1382-1393 |
JJ |
denotes |
spontaneous |
T3031 |
1405-1409 |
IN |
denotes |
from |
T3032 |
1410-1414 |
RB |
denotes |
fast |
T3033 |
1415-1422 |
VBG |
denotes |
cycling |
T3034 |
1414-1415 |
HYPH |
denotes |
- |
T3035 |
1444-1449 |
NNS |
denotes |
cells |
T3036 |
1422-1424 |
, |
denotes |
, |
T3037 |
1424-1440 |
JJ |
denotes |
undifferentiated |
T3038 |
1441-1443 |
NN |
denotes |
ES |
T3039 |
1450-1454 |
IN |
denotes |
into |
T3040 |
1455-1459 |
RBR |
denotes |
more |
T3041 |
1460-1466 |
RB |
denotes |
slowly |
T3042 |
1467-1474 |
VBG |
denotes |
cycling |
T3043 |
1496-1501 |
NNS |
denotes |
types |
T3044 |
1474-1476 |
, |
denotes |
, |
T3045 |
1476-1490 |
JJ |
denotes |
differentiated |
T3046 |
1491-1495 |
NN |
denotes |
cell |
T3047 |
1502-1504 |
IN |
denotes |
in |
T3048 |
1505-1510 |
DT |
denotes |
these |
T3049 |
1511-1519 |
NNS |
denotes |
cultures |
T3050 |
1519-1520 |
. |
denotes |
. |
R1530 |
T2767 |
T2768 |
aux |
To,investigate |
R1531 |
T2768 |
T2769 |
advcl |
investigate,analysed |
R1532 |
T2770 |
T2771 |
det |
a,defect |
R1533 |
T2771 |
T2768 |
dobj |
defect,investigate |
R1534 |
T2772 |
T2771 |
amod |
possible,defect |
R1535 |
T2773 |
T2774 |
compound |
cell,cycle |
R1536 |
T2774 |
T2771 |
compound |
cycle,defect |
R1537 |
T2775 |
T2774 |
punct |
-,cycle |
R1538 |
T2776 |
T2771 |
prep |
in,defect |
R1539 |
T2777 |
T2778 |
det |
the,absence |
R1540 |
T2778 |
T2776 |
pobj |
absence,in |
R1541 |
T2779 |
T2778 |
prep |
of,absence |
R1542 |
T2780 |
T2779 |
pobj |
Atrx,of |
R1543 |
T2781 |
T2769 |
punct |
", ",analysed |
R1544 |
T2782 |
T2769 |
nsubj |
we,analysed |
R1545 |
T2783 |
T2784 |
det |
the,distribution |
R1546 |
T2784 |
T2769 |
dobj |
distribution,analysed |
R1547 |
T2785 |
T2786 |
compound |
cell,cycle |
R1548 |
T2786 |
T2784 |
compound |
cycle,distribution |
R1549 |
T2787 |
T2784 |
prep |
of,distribution |
R1550 |
T2788 |
T2789 |
npadvmod |
bromodeoxyuridine,pulsed |
R1551 |
T2789 |
T2794 |
amod |
pulsed,cells |
R1552 |
T2790 |
T2788 |
punct |
(,bromodeoxyuridine |
R1553 |
T2791 |
T2788 |
appos |
BrdU,bromodeoxyuridine |
R1554 |
T2792 |
T2789 |
punct |
),pulsed |
R1555 |
T2793 |
T2789 |
punct |
-,pulsed |
R1556 |
T2794 |
T2787 |
pobj |
cells,of |
R1557 |
T2795 |
T2794 |
compound |
ES,cells |
R1558 |
T2796 |
T2769 |
prep |
by,analysed |
R1559 |
T2797 |
T2798 |
compound |
flow,cytometry |
R1560 |
T2798 |
T2796 |
pobj |
cytometry,by |
R1561 |
T2799 |
T2800 |
punct |
(,S1A |
R1562 |
T2800 |
T2769 |
parataxis |
S1A,analysed |
R1563 |
T2801 |
T2800 |
compound |
Figure,S1A |
R1564 |
T2802 |
T2800 |
punct |
),S1A |
R1565 |
T2803 |
T2769 |
punct |
.,analysed |
R1566 |
T2805 |
T2806 |
advmod |
Surprisingly,exhibited |
R1567 |
T2807 |
T2806 |
punct |
", ",exhibited |
R1568 |
T2808 |
T2809 |
det |
both,clones |
R1569 |
T2809 |
T2806 |
nsubj |
clones,exhibited |
R1570 |
T2810 |
T2811 |
amod |
Atrxnull,cell |
R1571 |
T2811 |
T2809 |
compound |
cell,clones |
R1572 |
T2812 |
T2811 |
compound |
ES,cell |
R1573 |
T2813 |
T2814 |
det |
a,profile |
R1574 |
T2814 |
T2806 |
dobj |
profile,exhibited |
R1575 |
T2815 |
T2816 |
compound |
cell,cycle |
R1576 |
T2816 |
T2814 |
compound |
cycle,profile |
R1577 |
T2817 |
T2818 |
dep |
that,was |
R1578 |
T2818 |
T2814 |
relcl |
was,profile |
R1579 |
T2819 |
T2818 |
acomp |
indistinguishable,was |
R1580 |
T2820 |
T2819 |
prep |
from,indistinguishable |
R1581 |
T2821 |
T2822 |
compound |
ES,cells |
R1582 |
T2822 |
T2820 |
pobj |
cells,from |
R1583 |
T2823 |
T2822 |
acl |
bearing,cells |
R1584 |
T2824 |
T2825 |
det |
a,allele |
R1585 |
T2825 |
T2823 |
dobj |
allele,bearing |
R1586 |
T2826 |
T2825 |
amod |
functional,allele |
R1587 |
T2827 |
T2825 |
compound |
Atrx,allele |
R1588 |
T2828 |
T2825 |
punct |
(,allele |
R1589 |
T2829 |
T2825 |
appos |
Atrx WT,allele |
R1590 |
T2830 |
T2829 |
cc |
or,Atrx WT |
R1591 |
T2831 |
T2829 |
conj |
Atrx flox,Atrx WT |
R1592 |
T2832 |
T2806 |
punct |
),exhibited |
R1593 |
T2833 |
T2806 |
punct |
.,exhibited |
R1594 |
T2835 |
T2836 |
nsubj |
We,quantitated |
R1595 |
T2837 |
T2836 |
advmod |
also,quantitated |
R1596 |
T2838 |
T2836 |
advmod |
specifically,quantitated |
R1597 |
T2839 |
T2840 |
det |
the,index |
R1598 |
T2840 |
T2836 |
dobj |
index,quantitated |
R1599 |
T2841 |
T2840 |
amod |
mitotic,index |
R1600 |
T2842 |
T2840 |
prep |
within,index |
R1601 |
T2843 |
T2844 |
det |
each,population |
R1602 |
T2844 |
T2842 |
pobj |
population,within |
R1603 |
T2845 |
T2836 |
prep |
by,quantitated |
R1604 |
T2846 |
T2847 |
compound |
flow,cytometry |
R1605 |
T2847 |
T2845 |
pobj |
cytometry,by |
R1606 |
T2848 |
T2836 |
prep |
after,quantitated |
R1607 |
T2849 |
T2848 |
pcomp |
staining,after |
R1608 |
T2850 |
T2851 |
compound |
ES,cells |
R1609 |
T2851 |
T2849 |
dobj |
cells,staining |
R1610 |
T2852 |
T2849 |
prep |
for,staining |
R1611 |
T2853 |
T2854 |
amod |
phosphorylated,H3 |
R1612 |
T2854 |
T2852 |
pobj |
H3,for |
R1613 |
T2855 |
T2856 |
punct |
(,Ser10 |
R1614 |
T2856 |
T2853 |
parataxis |
Ser10,phosphorylated |
R1615 |
T2857 |
T2856 |
punct |
),Ser10 |
R1616 |
T2858 |
T2854 |
compound |
histone,H3 |
R1617 |
T2859 |
T2854 |
punct |
", ",H3 |
R1618 |
T2860 |
T2861 |
det |
a,marker |
R1619 |
T2861 |
T2854 |
appos |
marker,H3 |
R1620 |
T2862 |
T2861 |
amod |
specific,marker |
R1621 |
T2863 |
T2861 |
prep |
of,marker |
R1622 |
T2864 |
T2863 |
pobj |
mitosis,of |
R1623 |
T2865 |
T2866 |
punct |
(,S1B |
R1624 |
T2866 |
T2836 |
parataxis |
S1B,quantitated |
R1625 |
T2867 |
T2866 |
compound |
Figure,S1B |
R1626 |
T2868 |
T2866 |
punct |
),S1B |
R1627 |
T2869 |
T2870 |
punct |
[,13 |
R1628 |
T2870 |
T2836 |
parataxis |
13,quantitated |
R1629 |
T2871 |
T2870 |
punct |
],13 |
R1630 |
T2872 |
T2836 |
punct |
.,quantitated |
R1631 |
T2874 |
T2875 |
advcl |
Consistent,was |
R1632 |
T2876 |
T2874 |
prep |
with,Consistent |
R1633 |
T2877 |
T2878 |
det |
the,profile |
R1634 |
T2878 |
T2876 |
pobj |
profile,with |
R1635 |
T2879 |
T2878 |
amod |
normal,profile |
R1636 |
T2880 |
T2881 |
compound |
cell,cycle |
R1637 |
T2881 |
T2878 |
compound |
cycle,profile |
R1638 |
T2882 |
T2881 |
punct |
-,cycle |
R1639 |
T2883 |
T2878 |
acl |
observed,profile |
R1640 |
T2884 |
T2883 |
advmod |
above,observed |
R1641 |
T2885 |
T2875 |
punct |
", ",was |
R1642 |
T2886 |
T2875 |
expl |
there,was |
R1643 |
T2887 |
T2888 |
det |
no,depletion |
R1644 |
T2888 |
T2875 |
attr |
depletion,was |
R1645 |
T2889 |
T2888 |
prep |
in,depletion |
R1646 |
T2890 |
T2891 |
det |
the,size |
R1647 |
T2891 |
T2889 |
pobj |
size,in |
R1648 |
T2892 |
T2891 |
prep |
of,size |
R1649 |
T2893 |
T2894 |
det |
the,population |
R1650 |
T2894 |
T2892 |
pobj |
population,of |
R1651 |
T2895 |
T2894 |
amod |
mitotic,population |
R1652 |
T2896 |
T2875 |
prep |
in,was |
R1653 |
T2897 |
T2898 |
det |
the,clones |
R1654 |
T2898 |
T2896 |
pobj |
clones,in |
R1655 |
T2899 |
T2898 |
amod |
Atrxnull,clones |
R1656 |
T2900 |
T2898 |
compound |
ES,clones |
R1657 |
T2901 |
T2875 |
punct |
", ",was |
R1658 |
T2902 |
T2875 |
prep |
despite,was |
R1659 |
T2903 |
T2904 |
poss |
their,growth |
R1660 |
T2904 |
T2902 |
pobj |
growth,despite |
R1661 |
T2905 |
T2904 |
amod |
slow,growth |
R1662 |
T2906 |
T2875 |
punct |
.,was |
R1663 |
T2908 |
T2909 |
advmod |
Finally,investigated |
R1664 |
T2910 |
T2909 |
punct |
", ",investigated |
R1665 |
T2911 |
T2909 |
nsubj |
we,investigated |
R1666 |
T2912 |
T2913 |
mark |
whether,was |
R1667 |
T2913 |
T2909 |
ccomp |
was,investigated |
R1668 |
T2914 |
T2915 |
det |
the,defect |
R1669 |
T2915 |
T2913 |
nsubj |
defect,was |
R1670 |
T2916 |
T2915 |
compound |
growth,defect |
R1671 |
T2917 |
T2915 |
prep |
in,defect |
R1672 |
T2918 |
T2919 |
det |
the,cells |
R1673 |
T2919 |
T2917 |
pobj |
cells,in |
R1674 |
T2920 |
T2921 |
amod |
Atrxnull,ES |
R1675 |
T2921 |
T2919 |
compound |
ES,cells |
R1676 |
T2922 |
T2913 |
prep |
due,was |
R1677 |
T2923 |
T2922 |
pcomp |
to,due |
R1678 |
T2924 |
T2925 |
det |
an,regulation |
R1679 |
T2925 |
T2922 |
pobj |
regulation,due |
R1680 |
T2926 |
T2925 |
amod |
up,regulation |
R1681 |
T2927 |
T2925 |
punct |
-,regulation |
R1682 |
T2928 |
T2925 |
prep |
of,regulation |
R1683 |
T2929 |
T2928 |
pobj |
apoptosis,of |
R1684 |
T2930 |
T2909 |
prep |
by,investigated |
R1685 |
T2931 |
T2930 |
pcomp |
staining,by |
R1686 |
T2932 |
T2931 |
dobj |
cells,staining |
R1687 |
T2933 |
T2931 |
prep |
with,staining |
R1688 |
T2934 |
T2933 |
pobj |
Annexin,with |
R1689 |
T2935 |
T2934 |
nummod |
V,Annexin |
R1690 |
T2936 |
T2937 |
punct |
(,S2 |
R1691 |
T2937 |
T2909 |
parataxis |
S2,investigated |
R1692 |
T2938 |
T2937 |
compound |
Figure,S2 |
R1693 |
T2939 |
T2937 |
punct |
),S2 |
R1694 |
T2940 |
T2909 |
cc |
and,investigated |
R1695 |
T2941 |
T2909 |
conj |
found,investigated |
R1696 |
T2942 |
T2943 |
mark |
that,affected |
R1697 |
T2943 |
T2941 |
ccomp |
affected,found |
R1698 |
T2944 |
T2945 |
det |
the,proportion |
R1699 |
T2945 |
T2943 |
nsubjpass |
proportion,affected |
R1700 |
T2946 |
T2945 |
prep |
of,proportion |
R1701 |
T2947 |
T2948 |
amod |
apoptotic,cells |
R1702 |
T2948 |
T2946 |
pobj |
cells,of |
R1703 |
T2949 |
T2943 |
auxpass |
was,affected |
R1704 |
T2950 |
T2943 |
neg |
not,affected |
R1705 |
T2951 |
T2943 |
advmod |
significantly,affected |
R1706 |
T2952 |
T2943 |
agent |
by,affected |
R1707 |
T2953 |
T2954 |
det |
the,absence |
R1708 |
T2954 |
T2952 |
pobj |
absence,by |
R1709 |
T2955 |
T2954 |
prep |
of,absence |
R1710 |
T2956 |
T2957 |
amod |
full,length |
R1711 |
T2957 |
T2959 |
compound |
length,Atrx |
R1712 |
T2958 |
T2957 |
punct |
-,length |
R1713 |
T2959 |
T2955 |
pobj |
Atrx,of |
R1714 |
T2960 |
T2909 |
punct |
.,investigated |
R1715 |
T2962 |
T2963 |
advmod |
Thus,is |
R1716 |
T2964 |
T2963 |
punct |
", ",is |
R1717 |
T2965 |
T2966 |
det |
the,defect |
R1718 |
T2966 |
T2963 |
nsubj |
defect,is |
R1719 |
T2967 |
T2966 |
compound |
growth,defect |
R1720 |
T2968 |
T2966 |
acl |
observed,defect |
R1721 |
T2969 |
T2968 |
prep |
in,observed |
R1722 |
T2970 |
T2971 |
compound |
ES,cells |
R1723 |
T2971 |
T2969 |
pobj |
cells,in |
R1724 |
T2972 |
T2971 |
acl |
lacking,cells |
R1725 |
T2973 |
T2972 |
dobj |
Atrx,lacking |
R1726 |
T2974 |
T2963 |
neg |
not,is |
R1727 |
T2975 |
T2963 |
prep |
due,is |
R1728 |
T2976 |
T2975 |
pcomp |
to,due |
R1729 |
T2977 |
T2978 |
det |
a,block |
R1730 |
T2978 |
T2975 |
pobj |
block,due |
R1731 |
T2979 |
T2978 |
amod |
specific,block |
R1732 |
T2980 |
T2981 |
compound |
cell,cycle |
R1733 |
T2981 |
T2978 |
compound |
cycle,block |
R1734 |
T2982 |
T2978 |
cc |
or,block |
R1735 |
T2983 |
T2984 |
amod |
significant,induction |
R1736 |
T2984 |
T2978 |
conj |
induction,block |
R1737 |
T2985 |
T2984 |
prep |
of,induction |
R1738 |
T2986 |
T2987 |
compound |
cell,death |
R1739 |
T2987 |
T2985 |
pobj |
death,of |
R1740 |
T2988 |
T2963 |
punct |
.,is |
R1741 |
T2990 |
T2991 |
mark |
While,is |
R1742 |
T2991 |
T2998 |
advcl |
is,seems |
R1743 |
T2992 |
T2993 |
det |
the,cause |
R1744 |
T2993 |
T2991 |
nsubj |
cause,is |
R1745 |
T2994 |
T2993 |
prep |
of,cause |
R1746 |
T2995 |
T2996 |
det |
the,delay |
R1747 |
T2996 |
T2994 |
pobj |
delay,of |
R1748 |
T2997 |
T2996 |
amod |
proliferative,delay |
R1749 |
T2999 |
T2991 |
neg |
not,is |
R1750 |
T3000 |
T2991 |
advmod |
yet,is |
R1751 |
T3001 |
T2991 |
acomp |
clear,is |
R1752 |
T3002 |
T2991 |
punct |
", ",is |
R1753 |
T3003 |
T3004 |
mark |
since,appear |
R1754 |
T3004 |
T2991 |
advcl |
appear,is |
R1755 |
T3005 |
T3006 |
amod |
Atrxnull,cells |
R1756 |
T3006 |
T3004 |
nsubj |
cells,appear |
R1757 |
T3007 |
T3006 |
compound |
ES,cells |
R1758 |
T3008 |
T3009 |
aux |
to,undergo |
R1759 |
T3009 |
T3004 |
xcomp |
undergo,appear |
R1760 |
T3010 |
T3011 |
amod |
higher,rates |
R1761 |
T3011 |
T3009 |
dobj |
rates,undergo |
R1762 |
T3012 |
T3011 |
prep |
of,rates |
R1763 |
T3013 |
T3014 |
amod |
spontaneous,differentiation |
R1764 |
T3014 |
T3012 |
pobj |
differentiation,of |
R1765 |
T3015 |
T3016 |
punct |
(,data |
R1766 |
T3016 |
T2991 |
meta |
data,is |
R1767 |
T3017 |
T3016 |
amod |
unpublished,data |
R1768 |
T3018 |
T3016 |
punct |
),data |
R1769 |
T3019 |
T2998 |
punct |
", ",seems |
R1770 |
T3020 |
T2998 |
nsubj |
it,seems |
R1771 |
T3021 |
T2998 |
oprd |
likely,seems |
R1772 |
T3022 |
T3023 |
mark |
that,reflects |
R1773 |
T3023 |
T2998 |
ccomp |
reflects,seems |
R1774 |
T3024 |
T3025 |
det |
the,defect |
R1775 |
T3025 |
T3023 |
nsubj |
defect,reflects |
R1776 |
T3026 |
T3025 |
amod |
observed,defect |
R1777 |
T3027 |
T3025 |
compound |
growth,defect |
R1778 |
T3028 |
T3029 |
det |
the,transition |
R1779 |
T3029 |
T3023 |
dobj |
transition,reflects |
R1780 |
T3030 |
T3029 |
amod |
spontaneous,transition |
R1781 |
T3031 |
T3029 |
prep |
from,transition |
R1782 |
T3032 |
T3033 |
advmod |
fast,cycling |
R1783 |
T3033 |
T3035 |
amod |
cycling,cells |
R1784 |
T3034 |
T3033 |
punct |
-,cycling |
R1785 |
T3035 |
T3031 |
pobj |
cells,from |
R1786 |
T3036 |
T3035 |
punct |
", ",cells |
R1787 |
T3037 |
T3035 |
amod |
undifferentiated,cells |
R1788 |
T3038 |
T3035 |
compound |
ES,cells |
R1789 |
T3039 |
T3029 |
prep |
into,transition |
R1790 |
T3040 |
T3041 |
advmod |
more,slowly |
R1791 |
T3041 |
T3042 |
advmod |
slowly,cycling |
R1792 |
T3042 |
T3043 |
amod |
cycling,types |
R1793 |
T3043 |
T3039 |
pobj |
types,into |
R1794 |
T3044 |
T3043 |
punct |
", ",types |
R1795 |
T3045 |
T3043 |
amod |
differentiated,types |
R1796 |
T3046 |
T3043 |
compound |
cell,types |
R1797 |
T3047 |
T3023 |
prep |
in,reflects |
R1798 |
T3048 |
T3049 |
det |
these,cultures |
R1799 |
T3049 |
T3047 |
pobj |
cultures,in |
R1800 |
T3050 |
T2998 |
punct |
.,seems |