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Id Subject Object Predicate Lexical cue
T2534 0-9 VBN denotes Perturbed
T2535 10-16 NN denotes Growth
T2536 17-20 CC denotes and
T2537 21-32 NN denotes Methylation
T2538 33-40 NNS denotes Defects
T2539 41-43 IN denotes in
T2540 44-52 JJ denotes Atrxnull
T2541 56-61 NNS denotes Cells
T2542 53-55 NN denotes ES
T2543 61-235 sentence denotes Atrxnull ES cells could be maintained in culture but were generally slower growing than Atrx+ ES clones, and appeared to undergo higher rates of spontaneous differentiation.
T2544 62-70 JJ denotes Atrxnull
T2545 74-79 NNS denotes cells
T2546 71-73 NN denotes ES
T2547 89-99 VBN denotes maintained
T2548 80-85 MD denotes could
T2549 86-88 VB denotes be
T2550 100-102 IN denotes in
T2551 103-110 NN denotes culture
T2552 111-114 CC denotes but
T2553 115-119 VBD denotes were
T2554 120-129 RB denotes generally
T2555 130-136 RBR denotes slower
T2556 137-144 VBG denotes growing
T2557 145-149 IN denotes than
T2558 150-154 NN denotes Atrx
T2559 156-158 NN denotes ES
T2560 154-155 SYM denotes +
T2561 159-165 NNS denotes clones
T2562 165-167 , denotes ,
T2563 167-170 CC denotes and
T2564 171-179 VBD denotes appeared
T2565 180-182 TO denotes to
T2566 183-190 VB denotes undergo
T2567 191-197 JJR denotes higher
T2568 198-203 NNS denotes rates
T2569 204-206 IN denotes of
T2570 207-218 JJ denotes spontaneous
T2571 219-234 NN denotes differentiation
T2572 234-235 . denotes .
T2573 235-369 sentence denotes We investigated directly the effect of Atrx on ES cell growth by comparing Atrx+ and Atrxnull ES cell clones in competition cultures.
T2574 236-238 PRP denotes We
T2575 239-251 VBD denotes investigated
T2576 252-260 RB denotes directly
T2577 261-264 DT denotes the
T2578 265-271 NN denotes effect
T2579 272-274 IN denotes of
T2580 275-279 NN denotes Atrx
T2581 280-282 IN denotes on
T2582 283-285 NN denotes ES
T2583 286-290 NN denotes cell
T2584 291-297 NN denotes growth
T2585 298-300 IN denotes by
T2586 301-310 VBG denotes comparing
T2587 311-315 NN denotes Atrx
T2588 338-344 NNS denotes clones
T2589 315-316 SYM denotes +
T2590 317-320 CC denotes and
T2591 321-329 JJ denotes Atrxnull
T2592 330-332 NN denotes ES
T2593 333-337 NN denotes cell
T2594 345-347 IN denotes in
T2595 348-359 NN denotes competition
T2596 360-368 NNS denotes cultures
T2597 368-369 . denotes .
T2598 369-599 sentence denotes Equal numbers of Atrx+ (bearing either an Atrx WT or an Atrx flox allele) and Atrxnull (bearing an Atrx Δ18Δneo allele) ES cells were inoculated into cultures and the mixed cultures were passaged (1:3 split) every 2 d for 8–10 d.
T2599 370-375 JJ denotes Equal
T2600 376-383 NNS denotes numbers
T2601 504-514 VBN denotes inoculated
T2602 384-386 IN denotes of
T2603 387-391 NN denotes Atrx
T2604 493-498 NNS denotes cells
T2605 391-392 SYM denotes +
T2606 393-394 -LRB- denotes (
T2607 394-401 VBG denotes bearing
T2608 402-408 CC denotes either
T2609 412-419 NN denotes Atrx WT
T2610 409-411 DT denotes an
T2611 420-422 CC denotes or
T2612 423-425 DT denotes an
T2613 426-435 NN denotes Atrx flox
T2614 436-442 NN denotes allele
T2615 442-443 -RRB- denotes )
T2616 444-447 CC denotes and
T2617 448-456 JJ denotes Atrxnull
T2618 457-458 -LRB- denotes (
T2619 458-465 VBG denotes bearing
T2620 466-468 DT denotes an
T2621 482-488 NN denotes allele
T2622 469-481 NN denotes Atrx Δ18Δneo
T2623 488-489 -RRB- denotes )
T2624 490-492 NN denotes ES
T2625 499-503 VBD denotes were
T2626 515-519 IN denotes into
T2627 520-528 NNS denotes cultures
T2628 529-532 CC denotes and
T2629 533-536 DT denotes the
T2630 543-551 NNS denotes cultures
T2631 537-542 VBN denotes mixed
T2632 557-565 VBN denotes passaged
T2633 552-556 VBD denotes were
T2634 566-567 -LRB- denotes (
T2635 571-576 NN denotes split
T2636 567-568 CD denotes 1
T2637 568-569 SYM denotes :
T2638 569-570 CD denotes 3
T2639 576-577 -RRB- denotes )
T2640 578-583 DT denotes every
T2641 586-587 NNS denotes d
T2642 584-585 CD denotes 2
T2643 588-591 IN denotes for
T2644 592-593 CD denotes 8
T2645 594-596 CD denotes 10
T2646 593-594 SYM denotes –
T2647 597-598 NNS denotes d
T2648 598-599 . denotes .
T2649 599-728 sentence denotes The relative abundance of the different alleles in the culture at each time point was analysed by Southern blotting (Figure 3A).
T2650 600-603 DT denotes The
T2651 613-622 NN denotes abundance
T2652 604-612 JJ denotes relative
T2653 686-694 VBN denotes analysed
T2654 623-625 IN denotes of
T2655 626-629 DT denotes the
T2656 640-647 NNS denotes alleles
T2657 630-639 JJ denotes different
T2658 648-650 IN denotes in
T2659 651-654 DT denotes the
T2660 655-662 NN denotes culture
T2661 663-665 IN denotes at
T2662 666-670 DT denotes each
T2663 676-681 NN denotes point
T2664 671-675 NN denotes time
T2665 682-685 VBD denotes was
T2666 695-697 IN denotes by
T2667 698-706 NNP denotes Southern
T2668 707-715 NN denotes blotting
T2669 716-717 -LRB- denotes (
T2670 724-726 NN denotes 3A
T2671 717-723 NN denotes Figure
T2672 726-727 -RRB- denotes )
T2673 727-728 . denotes .
T2674 728-859 sentence denotes The clone containing the Atrx Δ18Δneo allele was rapidly outgrown by both Atrx WT ES cells and cells bearing the Atrx flox allele.
T2675 729-732 DT denotes The
T2676 733-738 NN denotes clone
T2677 786-794 VBN denotes outgrown
T2678 739-749 VBG denotes containing
T2679 750-753 DT denotes the
T2680 767-773 NN denotes allele
T2681 754-766 NN denotes Atrx Δ18Δneo
T2682 774-777 VBD denotes was
T2683 778-785 RB denotes rapidly
T2684 795-797 IN denotes by
T2685 798-802 CC denotes both
T2686 814-819 NNS denotes cells
T2687 803-810 NN denotes Atrx WT
T2688 811-813 NN denotes ES
T2689 820-823 CC denotes and
T2690 824-829 NNS denotes cells
T2691 830-837 VBG denotes bearing
T2692 838-841 DT denotes the
T2693 852-858 NN denotes allele
T2694 842-851 NN denotes Atrx flox
T2695 858-859 . denotes .
T2696 859-1053 sentence denotes In a control competition experiment between different clones bearing functional Atrx alleles (Atrx WT and Atrx flox), both clones continued to be equally represented after 8 d of cocultivation.
T2697 860-862 IN denotes In
T2698 990-999 VBD denotes continued
T2699 863-864 DT denotes a
T2700 885-895 NN denotes experiment
T2701 865-872 NN denotes control
T2702 873-884 NN denotes competition
T2703 896-903 IN denotes between
T2704 904-913 JJ denotes different
T2705 914-920 NNS denotes clones
T2706 921-928 VBG denotes bearing
T2707 929-939 JJ denotes functional
T2708 945-952 NNS denotes alleles
T2709 940-944 NN denotes Atrx
T2710 953-954 -LRB- denotes (
T2711 954-961 NN denotes Atrx WT
T2712 962-965 CC denotes and
T2713 966-975 NN denotes Atrx flox
T2714 975-976 -RRB- denotes )
T2715 976-978 , denotes ,
T2716 978-982 DT denotes both
T2717 983-989 NNS denotes clones
T2718 1000-1002 TO denotes to
T2719 1003-1005 VB denotes be
T2720 1006-1013 RB denotes equally
T2721 1014-1025 JJ denotes represented
T2722 1026-1031 IN denotes after
T2723 1032-1033 CD denotes 8
T2724 1034-1035 NNS denotes d
T2725 1036-1038 IN denotes of
T2726 1039-1052 NN denotes cocultivation
T2727 1052-1053 . denotes .
T2728 1053-1286 sentence denotes Thus, although Atrxnull ES cells could be recovered and maintained in culture by a conditional targeting approach, these cocultivation experiments suggested that the absence of Atrx does negatively impact upon normal ES cell growth.
T2729 1054-1058 RB denotes Thus
T2730 1201-1210 VBD denotes suggested
T2731 1058-1060 , denotes ,
T2732 1060-1068 IN denotes although
T2733 1096-1105 VBN denotes recovered
T2734 1069-1077 JJ denotes Atrxnull
T2735 1081-1086 NNS denotes cells
T2736 1078-1080 NN denotes ES
T2737 1087-1092 MD denotes could
T2738 1093-1095 VB denotes be
T2739 1106-1109 CC denotes and
T2740 1110-1120 VBN denotes maintained
T2741 1121-1123 IN denotes in
T2742 1124-1131 NN denotes culture
T2743 1132-1134 IN denotes by
T2744 1135-1136 DT denotes a
T2745 1159-1167 NN denotes approach
T2746 1137-1148 JJ denotes conditional
T2747 1149-1158 NN denotes targeting
T2748 1167-1169 , denotes ,
T2749 1169-1174 DT denotes these
T2750 1189-1200 NNS denotes experiments
T2751 1175-1188 NN denotes cocultivation
T2752 1211-1215 IN denotes that
T2753 1252-1258 VB denotes impact
T2754 1216-1219 DT denotes the
T2755 1220-1227 NN denotes absence
T2756 1228-1230 IN denotes of
T2757 1231-1235 NN denotes Atrx
T2758 1236-1240 VBZ denotes does
T2759 1241-1251 RB denotes negatively
T2760 1259-1263 IN denotes upon
T2761 1264-1270 JJ denotes normal
T2762 1279-1285 NN denotes growth
T2764 1274-1278 NN denotes cell
T2765 1285-1286 . denotes .
T2766 1286-3152 sentence denotes Figure 3 Growth and Methylation Defects in Atrxnull ES Cells (A) Cultures were inoculated with equivalent numbers of ES cells bearing different Atrx alleles as indicated, and were serially passaged. After the indicated days of coculture, DNA extracted from a sample of cells was analysed by Southern blot to detect the Atrx alleles. DNA was digested with SpeI, and the membrane was hybridised with the 20/27 probe shown in Figure 2A. The expected sizes of the different alleles are indicated. (B) Schematic diagram of the transcribed portion of the mouse rDNA repeat with the 18S, 5.8S, and 28S genes indicated. The positions of the limit-digesting enzymes BamH (labelled B) and EcoRI (labelled E) and the probes (RIB3 and RIB4) used in the Southern blots shown in (C) are indicated. Below are shown the locations of the methylation-sensitive enzymes (SmaI, PvuI, and MluI) whose methylation status has been analysed in the Southern blots shown in (C). (C) DNA from Atrx-positive (Atrx+, bearing either an Atrx WT or Atrx flox allele) or Atrxnull (bearing the Atrx Δ18Δneo allele) ES cells and 7-d embryoid bodies were digested with the enzymes shown and analysed by Southern blotting using the probes indicated. Arrows indicate the fully methylated copies (cut by only the limit-digesting enzyme). Phosphorimager quantitation of the blots are shown below. The y-axis shows the percentage of copies that are undigested by the methylation-sensitive enzyme as a percentage of the total signal from cut and uncut rDNA. Mean values are indicated by horizontal lines, and the significance of the differences between the Atrx-positive and Atrxnull populations are shown for each enzyme. To investigate a possible cell-cycle defect in the absence of Atrx, we analysed the cell cycle distribution of bromodeoxyuridine (BrdU)-pulsed ES cells by flow cytometry (Figure S1A).
T2767 2969-2971 TO denotes To
T2768 2972-2983 VB denotes investigate
T2769 3040-3048 VBD denotes analysed
T2770 2984-2985 DT denotes a
T2771 3006-3012 NN denotes defect
T2772 2986-2994 JJ denotes possible
T2773 2995-2999 NN denotes cell
T2774 3000-3005 NN denotes cycle
T2775 2999-3000 HYPH denotes -
T2776 3013-3015 IN denotes in
T2777 3016-3019 DT denotes the
T2778 3020-3027 NN denotes absence
T2779 3028-3030 IN denotes of
T2780 3031-3035 NN denotes Atrx
T2781 3035-3037 , denotes ,
T2782 3037-3039 PRP denotes we
T2783 3049-3052 DT denotes the
T2784 3064-3076 NN denotes distribution
T2785 3053-3057 NN denotes cell
T2786 3058-3063 NN denotes cycle
T2787 3077-3079 IN denotes of
T2788 3080-3097 NN denotes bromodeoxyuridine
T2789 3105-3111 VBN denotes pulsed
T2790 3098-3099 -LRB- denotes (
T2791 3099-3103 NN denotes BrdU
T2792 3103-3104 -RRB- denotes )
T2793 3104-3105 HYPH denotes -
T2794 3115-3120 NNS denotes cells
T2795 3112-3114 NN denotes ES
T2796 3121-3123 IN denotes by
T2797 3124-3128 NN denotes flow
T2798 3129-3138 NN denotes cytometry
T2799 3139-3140 -LRB- denotes (
T2800 3147-3150 NN denotes S1A
T2801 3140-3146 NN denotes Figure
T2802 3150-3151 -RRB- denotes )
T2803 3151-3152 . denotes .
T2804 3152-3324 sentence denotes Surprisingly, both Atrxnull ES cell clones exhibited a cell cycle profile that was indistinguishable from ES cells bearing a functional Atrx allele (Atrx WT or Atrx flox).
T2805 3153-3165 RB denotes Surprisingly
T2806 3196-3205 VBD denotes exhibited
T2807 3165-3167 , denotes ,
T2808 3167-3171 DT denotes both
T2809 3189-3195 NNS denotes clones
T2810 3172-3180 JJ denotes Atrxnull
T2811 3184-3188 NN denotes cell
T2812 3181-3183 NN denotes ES
T2813 3206-3207 DT denotes a
T2814 3219-3226 NN denotes profile
T2815 3208-3212 NN denotes cell
T2816 3213-3218 NN denotes cycle
T2817 3227-3231 WDT denotes that
T2818 3232-3235 VBD denotes was
T2819 3236-3253 JJ denotes indistinguishable
T2820 3254-3258 IN denotes from
T2821 3259-3261 NN denotes ES
T2822 3262-3267 NNS denotes cells
T2823 3268-3275 VBG denotes bearing
T2824 3276-3277 DT denotes a
T2825 3294-3300 NN denotes allele
T2826 3278-3288 JJ denotes functional
T2827 3289-3293 NN denotes Atrx
T2828 3301-3302 -LRB- denotes (
T2829 3302-3309 NN denotes Atrx WT
T2830 3310-3312 CC denotes or
T2831 3313-3322 NN denotes Atrx flox
T2832 3322-3323 -RRB- denotes )
T2833 3323-3324 . denotes .
T2834 3324-3527 sentence denotes We also specifically quantitated the mitotic index within each population by flow cytometry after staining ES cells for phosphorylated (Ser10) histone H3, a specific marker of mitosis (Figure S1B) [13].
T2835 3325-3327 PRP denotes We
T2836 3346-3357 VBD denotes quantitated
T2837 3328-3332 RB denotes also
T2838 3333-3345 RB denotes specifically
T2839 3358-3361 DT denotes the
T2840 3370-3375 NN denotes index
T2841 3362-3369 JJ denotes mitotic
T2842 3376-3382 IN denotes within
T2843 3383-3387 DT denotes each
T2844 3388-3398 NN denotes population
T2845 3399-3401 IN denotes by
T2846 3402-3406 NN denotes flow
T2847 3407-3416 NN denotes cytometry
T2848 3417-3422 IN denotes after
T2849 3423-3431 VBG denotes staining
T2850 3432-3434 NN denotes ES
T2851 3435-3440 NNS denotes cells
T2852 3441-3444 IN denotes for
T2853 3445-3459 VBN denotes phosphorylated
T2854 3476-3478 NN denotes H3
T2855 3460-3461 -LRB- denotes (
T2856 3461-3466 NN denotes Ser10
T2857 3466-3467 -RRB- denotes )
T2858 3468-3475 NN denotes histone
T2859 3478-3480 , denotes ,
T2860 3480-3481 DT denotes a
T2861 3491-3497 NN denotes marker
T2862 3482-3490 JJ denotes specific
T2863 3498-3500 IN denotes of
T2864 3501-3508 NN denotes mitosis
T2865 3509-3510 -LRB- denotes (
T2866 3517-3520 NN denotes S1B
T2867 3510-3516 NN denotes Figure
T2868 3520-3521 -RRB- denotes )
T2869 3522-3523 -LRB- denotes [
T2870 3523-3525 CD denotes 13
T2871 3525-3526 -RRB- denotes ]
T2872 3526-3527 . denotes .
T2873 3527-3704 sentence denotes Consistent with the normal cell-cycle profile observed above, there was no depletion in the size of the mitotic population in the Atrxnull ES clones, despite their slow growth.
T2874 3528-3538 JJ denotes Consistent
T2875 3596-3599 VBD denotes was
T2876 3539-3543 IN denotes with
T2877 3544-3547 DT denotes the
T2878 3566-3573 NN denotes profile
T2879 3548-3554 JJ denotes normal
T2880 3555-3559 NN denotes cell
T2881 3560-3565 NN denotes cycle
T2882 3559-3560 HYPH denotes -
T2883 3574-3582 VBN denotes observed
T2884 3583-3588 RB denotes above
T2885 3588-3590 , denotes ,
T2886 3590-3595 EX denotes there
T2887 3600-3602 DT denotes no
T2888 3603-3612 NN denotes depletion
T2889 3613-3615 IN denotes in
T2890 3616-3619 DT denotes the
T2891 3620-3624 NN denotes size
T2892 3625-3627 IN denotes of
T2893 3628-3631 DT denotes the
T2894 3640-3650 NN denotes population
T2895 3632-3639 JJ denotes mitotic
T2896 3651-3653 IN denotes in
T2897 3654-3657 DT denotes the
T2898 3670-3676 NNS denotes clones
T2899 3658-3666 JJ denotes Atrxnull
T2900 3667-3669 NN denotes ES
T2901 3676-3678 , denotes ,
T2902 3678-3685 IN denotes despite
T2903 3686-3691 PRP$ denotes their
T2904 3697-3703 NN denotes growth
T2905 3692-3696 JJ denotes slow
T2906 3703-3704 . denotes .
T2907 3704-3982 sentence denotes Finally, we investigated whether the growth defect in the Atrxnull ES cells was due to an up-regulation of apoptosis by staining cells with Annexin V (Figure S2) and found that the proportion of apoptotic cells was not significantly affected by the absence of full-length Atrx.
T2908 3705-3712 RB denotes Finally
T2909 3717-3729 VBD denotes investigated
T2910 3712-3714 , denotes ,
T2911 3714-3716 PRP denotes we
T2912 3730-3737 IN denotes whether
T2913 3781-3784 VBD denotes was
T2914 3738-3741 DT denotes the
T2915 3749-3755 NN denotes defect
T2916 3742-3748 NN denotes growth
T2917 3756-3758 IN denotes in
T2918 3759-3762 DT denotes the
T2919 3775-3780 NNS denotes cells
T2920 3763-3771 JJ denotes Atrxnull
T2921 3772-3774 NN denotes ES
T2922 3785-3788 IN denotes due
T2923 3789-3791 IN denotes to
T2924 3792-3794 DT denotes an
T2925 3798-3808 NN denotes regulation
T2926 3795-3797 JJ denotes up
T2927 3797-3798 HYPH denotes -
T2928 3809-3811 IN denotes of
T2929 3812-3821 NN denotes apoptosis
T2930 3822-3824 IN denotes by
T2931 3825-3833 VBG denotes staining
T2932 3834-3839 NNS denotes cells
T2933 3840-3844 IN denotes with
T2934 3845-3852 NN denotes Annexin
T2935 3853-3854 CD denotes V
T2936 3855-3856 -LRB- denotes (
T2937 3863-3865 NN denotes S2
T2938 3856-3862 NN denotes Figure
T2939 3865-3866 -RRB- denotes )
T2940 3867-3870 CC denotes and
T2941 3871-3876 VBD denotes found
T2942 3877-3881 IN denotes that
T2943 3938-3946 VBN denotes affected
T2944 3882-3885 DT denotes the
T2945 3886-3896 NN denotes proportion
T2946 3897-3899 IN denotes of
T2947 3900-3909 JJ denotes apoptotic
T2948 3910-3915 NNS denotes cells
T2949 3916-3919 VBD denotes was
T2950 3920-3923 RB denotes not
T2951 3924-3937 RB denotes significantly
T2952 3947-3949 IN denotes by
T2953 3950-3953 DT denotes the
T2954 3954-3961 NN denotes absence
T2955 3962-3964 IN denotes of
T2956 3965-3969 JJ denotes full
T2957 3970-3976 NN denotes length
T2958 3969-3970 HYPH denotes -
T2959 3977-3981 NN denotes Atrx
T2960 3981-3982 . denotes .
T2961 3982-4122 sentence denotes Thus, the growth defect observed in ES cells lacking Atrx is not due to a specific cell cycle block or significant induction of cell death.
T2962 3983-3987 RB denotes Thus
T2963 4041-4043 VBZ denotes is
T2964 3987-3989 , denotes ,
T2965 3989-3992 DT denotes the
T2966 4000-4006 NN denotes defect
T2967 3993-3999 NN denotes growth
T2968 4007-4015 VBN denotes observed
T2969 4016-4018 IN denotes in
T2970 4019-4021 NN denotes ES
T2971 4022-4027 NNS denotes cells
T2972 4028-4035 VBG denotes lacking
T2973 4036-4040 NN denotes Atrx
T2974 4044-4047 RB denotes not
T2975 4048-4051 IN denotes due
T2976 4052-4054 IN denotes to
T2977 4055-4056 DT denotes a
T2978 4077-4082 NN denotes block
T2979 4057-4065 JJ denotes specific
T2980 4066-4070 NN denotes cell
T2981 4071-4076 NN denotes cycle
T2982 4083-4085 CC denotes or
T2983 4086-4097 JJ denotes significant
T2984 4098-4107 NN denotes induction
T2985 4108-4110 IN denotes of
T2986 4111-4115 NN denotes cell
T2987 4116-4121 NN denotes death
T2988 4121-4122 . denotes .
T2989 4122-4489 sentence denotes While the cause of the proliferative delay is not yet clear, since Atrxnull ES cells appear to undergo higher rates of spontaneous differentiation (unpublished data), it seems likely that the observed growth defect reflects the spontaneous transition from fast-cycling, undifferentiated ES cells into more slowly cycling, differentiated cell types in these cultures.
T2990 4123-4128 IN denotes While
T2991 4166-4168 VBZ denotes is
T2992 4129-4132 DT denotes the
T2993 4133-4138 NN denotes cause
T2994 4139-4141 IN denotes of
T2995 4142-4145 DT denotes the
T2996 4160-4165 NN denotes delay
T2997 4146-4159 JJ denotes proliferative
T2998 4293-4298 VBZ denotes seems
T2999 4169-4172 RB denotes not
T3000 4173-4176 RB denotes yet
T3001 4177-4182 JJ denotes clear
T3002 4182-4184 , denotes ,
T3003 4184-4189 IN denotes since
T3004 4208-4214 VBP denotes appear
T3005 4190-4198 JJ denotes Atrxnull
T3006 4202-4207 NNS denotes cells
T3007 4199-4201 NN denotes ES
T3008 4215-4217 TO denotes to
T3009 4218-4225 VB denotes undergo
T3010 4226-4232 JJR denotes higher
T3011 4233-4238 NNS denotes rates
T3012 4239-4241 IN denotes of
T3013 4242-4253 JJ denotes spontaneous
T3014 4254-4269 NN denotes differentiation
T3015 4270-4271 -LRB- denotes (
T3016 4283-4287 NNS denotes data
T3017 4271-4282 JJ denotes unpublished
T3018 4287-4288 -RRB- denotes )
T3019 4288-4290 , denotes ,
T3020 4290-4292 PRP denotes it
T3021 4299-4305 JJ denotes likely
T3022 4306-4310 IN denotes that
T3023 4338-4346 VBZ denotes reflects
T3024 4311-4314 DT denotes the
T3025 4331-4337 NN denotes defect
T3026 4315-4323 VBN denotes observed
T3027 4324-4330 NN denotes growth
T3028 4347-4350 DT denotes the
T3029 4363-4373 NN denotes transition
T3030 4351-4362 JJ denotes spontaneous
T3031 4374-4378 IN denotes from
T3032 4379-4383 RB denotes fast
T3033 4384-4391 VBG denotes cycling
T3034 4383-4384 HYPH denotes -
T3035 4413-4418 NNS denotes cells
T3036 4391-4393 , denotes ,
T3037 4393-4409 JJ denotes undifferentiated
T3038 4410-4412 NN denotes ES
T3039 4419-4423 IN denotes into
T3040 4424-4428 RBR denotes more
T3041 4429-4435 RB denotes slowly
T3042 4436-4443 VBG denotes cycling
T3043 4465-4470 NNS denotes types
T3044 4443-4445 , denotes ,
T3045 4445-4459 JJ denotes differentiated
T3046 4460-4464 NN denotes cell
T3047 4471-4473 IN denotes in
T3048 4474-4479 DT denotes these
T3049 4480-4488 NNS denotes cultures
T3050 4488-4489 . denotes .
T3051 4489-4685 sentence denotes It has been shown that disease-causing mutations in the human ATRX gene give rise to changes in the normal pattern of DNA methylation at several repetitive sequences within the human genome [11].
T3052 4490-4492 PRP denotes It
T3053 4502-4507 VBN denotes shown
T3054 4493-4496 VBZ denotes has
T3055 4497-4501 VBN denotes been
T3056 4508-4512 IN denotes that
T3057 4562-4566 VBP denotes give
T3058 4513-4520 NN denotes disease
T3059 4521-4528 VBG denotes causing
T3060 4520-4521 HYPH denotes -
T3061 4529-4538 NNS denotes mutations
T3062 4539-4541 IN denotes in
T3063 4542-4545 DT denotes the
T3064 4557-4561 NN denotes gene
T3065 4546-4551 JJ denotes human
T3066 4552-4556 NN denotes ATRX
T3067 4567-4571 NN denotes rise
T3068 4572-4574 IN denotes to
T3069 4575-4582 NNS denotes changes
T3070 4583-4585 IN denotes in
T3071 4586-4589 DT denotes the
T3072 4597-4604 NN denotes pattern
T3073 4590-4596 JJ denotes normal
T3074 4605-4607 IN denotes of
T3075 4608-4611 NN denotes DNA
T3076 4612-4623 NN denotes methylation
T3077 4624-4626 IN denotes at
T3078 4627-4634 JJ denotes several
T3079 4646-4655 NNS denotes sequences
T3080 4635-4645 JJ denotes repetitive
T3081 4656-4662 IN denotes within
T3082 4663-4666 DT denotes the
T3083 4673-4679 NN denotes genome
T3084 4667-4672 JJ denotes human
T3085 4680-4681 -LRB- denotes [
T3086 4681-4683 CD denotes 11
T3087 4683-4684 -RRB- denotes ]
T3088 4684-4685 . denotes .
T3089 4685-4847 sentence denotes Notably, the transcribed region of the ribosomal DNA (rDNA) repeat was found to be significantly hypomethylated in ATR-X patients relative to normal individuals.
T3090 4686-4693 RB denotes Notably
T3091 4757-4762 VBN denotes found
T3092 4693-4695 , denotes ,
T3093 4695-4698 DT denotes the
T3094 4711-4717 NN denotes region
T3095 4699-4710 VBN denotes transcribed
T3096 4718-4720 IN denotes of
T3097 4721-4724 DT denotes the
T3098 4746-4752 NN denotes repeat
T3099 4725-4734 JJ denotes ribosomal
T3100 4735-4738 NN denotes DNA
T3101 4739-4740 -LRB- denotes (
T3102 4740-4744 NN denotes rDNA
T3103 4744-4745 -RRB- denotes )
T3104 4753-4756 VBD denotes was
T3105 4763-4765 TO denotes to
T3106 4783-4797 VBN denotes hypomethylated
T3107 4766-4768 VB denotes be
T3108 4769-4782 RB denotes significantly
T3109 4798-4800 IN denotes in
T3110 4801-4804 NN denotes ATR
T3111 4805-4806 NN denotes X
T3112 4804-4805 HYPH denotes -
T3113 4807-4815 NNS denotes patients
T3114 4816-4824 JJ denotes relative
T3115 4825-4827 IN denotes to
T3116 4828-4834 JJ denotes normal
T3117 4835-4846 NNS denotes individuals
T3118 4846-4847 . denotes .
T3119 4847-5158 sentence denotes Using methylation-sensitive restriction enzymes, we also observed significant hypomethylation at several sites tested within the mouse rDNA repeats in Atrxnull ES cells and 12-d embryoid bodies relative to ES cells and embryoid bodies bearing a functional Atrx allele (Atrx WT or Atrx flox) (Figure 3B and 3C).
T3120 4848-4853 VBG denotes Using
T3121 4905-4913 VBD denotes observed
T3122 4854-4865 NN denotes methylation
T3123 4866-4875 JJ denotes sensitive
T3124 4865-4866 HYPH denotes -
T3125 4888-4895 NNS denotes enzymes
T3126 4876-4887 NN denotes restriction
T3127 4895-4897 , denotes ,
T3128 4897-4899 PRP denotes we
T3129 4900-4904 RB denotes also
T3130 4914-4925 JJ denotes significant
T3131 4926-4941 NN denotes hypomethylation
T3132 4942-4944 IN denotes at
T3133 4945-4952 JJ denotes several
T3134 4953-4958 NNS denotes sites
T3135 4959-4965 VBN denotes tested
T3136 4966-4972 IN denotes within
T3137 4973-4976 DT denotes the
T3138 4988-4995 NNS denotes repeats
T3139 4977-4982 NN denotes mouse
T3140 4983-4987 NN denotes rDNA
T3141 4996-4998 IN denotes in
T3142 4999-5007 JJ denotes Atrxnull
T3143 5011-5016 NNS denotes cells
T3144 5008-5010 NN denotes ES
T3145 5017-5020 CC denotes and
T3146 5021-5023 CD denotes 12
T3147 5024-5025 NN denotes d
T3148 5023-5024 HYPH denotes -
T3149 5035-5041 NNS denotes bodies
T3150 5026-5034 JJ denotes embryoid
T3151 5042-5050 JJ denotes relative
T3152 5051-5053 IN denotes to
T3153 5054-5056 NN denotes ES
T3154 5057-5062 NNS denotes cells
T3155 5063-5066 CC denotes and
T3156 5067-5075 JJ denotes embryoid
T3157 5076-5082 NNS denotes bodies
T3158 5083-5090 VBG denotes bearing
T3159 5091-5092 DT denotes a
T3160 5109-5115 NN denotes allele
T3161 5093-5103 JJ denotes functional
T3162 5104-5108 NN denotes Atrx
T3163 5116-5117 -LRB- denotes (
T3164 5117-5124 NN denotes Atrx WT
T3165 5125-5127 CC denotes or
T3166 5128-5137 NN denotes Atrx flox
T3167 5137-5138 -RRB- denotes )
T3168 5139-5140 -LRB- denotes (
T3169 5147-5149 NN denotes 3B
T3170 5140-5146 NN denotes Figure
T3171 5150-5153 CC denotes and
T3172 5154-5156 NN denotes 3C
T3173 5156-5157 -RRB- denotes )
T3174 5157-5158 . denotes .
T3175 5158-5389 sentence denotes The observation that rDNA is hypomethylated in the absence of Atrx, even in ES cells, is consistent with the finding that hypomethylation of the human rDNA repeats is detectable from an early developmental stage in ATR-X patients.
T3176 5159-5162 DT denotes The
T3177 5163-5174 NN denotes observation
T3178 5245-5247 VBZ denotes is
T3179 5175-5179 IN denotes that
T3180 5188-5202 VBN denotes hypomethylated
T3181 5180-5184 NN denotes rDNA
T3182 5185-5187 VBZ denotes is
T3183 5203-5205 IN denotes in
T3184 5206-5209 DT denotes the
T3185 5210-5217 NN denotes absence
T3186 5218-5220 IN denotes of
T3187 5221-5225 NN denotes Atrx
T3188 5225-5227 , denotes ,
T3189 5227-5231 RB denotes even
T3190 5232-5234 IN denotes in
T3191 5235-5237 NN denotes ES
T3192 5238-5243 NNS denotes cells
T3193 5243-5245 , denotes ,
T3194 5248-5258 JJ denotes consistent
T3195 5259-5263 IN denotes with
T3196 5264-5267 DT denotes the
T3197 5268-5275 NN denotes finding
T3198 5276-5280 IN denotes that
T3199 5323-5325 VBZ denotes is
T3200 5281-5296 NN denotes hypomethylation
T3201 5297-5299 IN denotes of
T3202 5300-5303 DT denotes the
T3203 5315-5322 NNS denotes repeats
T3204 5304-5309 JJ denotes human
T3205 5310-5314 NN denotes rDNA
T3206 5326-5336 JJ denotes detectable
T3207 5337-5341 IN denotes from
T3208 5342-5344 DT denotes an
T3209 5365-5370 NN denotes stage
T3210 5345-5350 JJ denotes early
T3211 5351-5364 JJ denotes developmental
T3212 5371-5373 IN denotes in
T3213 5374-5377 NN denotes ATR
T3214 5378-5379 NN denotes X
T3215 5377-5378 HYPH denotes -
T3216 5380-5388 NNS denotes patients
T3217 5388-5389 . denotes .
T3218 5389-5718 sentence denotes Other mouse repetitive sequence elements surveyed in ES cell DNA include the heterochromatic major satellite (assayed with MaeII) and minor satellite (assayed with HpaII) repeats, as well as interspersed retroviral repeats of the intracisternal A particle (IAP) type and the Line 1 and Sine B1 families (all assayed with HpaII).
T3219 5390-5395 JJ denotes Other
T3220 5422-5430 NNS denotes elements
T3221 5396-5401 NN denotes mouse
T3222 5402-5412 JJ denotes repetitive
T3223 5413-5421 NN denotes sequence
T3224 5455-5462 VBP denotes include
T3225 5431-5439 VBN denotes surveyed
T3226 5440-5442 IN denotes in
T3227 5443-5445 NN denotes ES
T3228 5451-5454 NN denotes DNA
T3229 5446-5450 NN denotes cell
T3230 5463-5466 DT denotes the
T3231 5561-5568 NNS denotes repeats
T3232 5467-5482 JJ denotes heterochromatic
T3233 5489-5498 NN denotes satellite
T3234 5483-5488 JJ denotes major
T3235 5499-5500 -LRB- denotes (
T3236 5500-5507 VBN denotes assayed
T3237 5508-5512 IN denotes with
T3238 5513-5518 NN denotes MaeII
T3239 5518-5519 -RRB- denotes )
T3240 5520-5523 CC denotes and
T3241 5524-5529 JJ denotes minor
T3242 5530-5539 NN denotes satellite
T3243 5540-5541 -LRB- denotes (
T3244 5541-5548 VBN denotes assayed
T3245 5549-5553 IN denotes with
T3246 5554-5559 NN denotes HpaII
T3247 5559-5560 -RRB- denotes )
T3248 5568-5570 , denotes ,
T3249 5570-5572 RB denotes as
T3250 5578-5580 IN denotes as
T3251 5573-5577 RB denotes well
T3252 5581-5593 VBN denotes interspersed
T3253 5605-5612 NNS denotes repeats
T3254 5594-5604 JJ denotes retroviral
T3255 5613-5615 IN denotes of
T3256 5616-5619 DT denotes the
T3257 5652-5656 NN denotes type
T3258 5620-5634 JJ denotes intracisternal
T3259 5637-5645 NN denotes particle
T3260 5635-5636 NN denotes A
T3261 5646-5647 -LRB- denotes (
T3262 5647-5650 NN denotes IAP
T3263 5650-5651 -RRB- denotes )
T3264 5657-5660 CC denotes and
T3265 5661-5664 DT denotes the
T3266 5684-5692 NNS denotes families
T3267 5665-5669 NN denotes Line
T3268 5670-5671 CD denotes 1
T3269 5672-5675 CC denotes and
T3270 5676-5680 NN denotes Sine
T3271 5681-5683 NN denotes B1
T3272 5693-5694 -LRB- denotes (
T3273 5694-5697 DT denotes all
T3274 5698-5705 VBN denotes assayed
T3275 5706-5710 IN denotes with
T3276 5711-5716 NN denotes HpaII
T3277 5716-5717 -RRB- denotes )
T3278 5717-5718 . denotes .
T3279 5718-5972 sentence denotes These repeats were found to be moderately (Line 1 and Sine B1) or highly (IAP, major satellite, minor satellite) methylated in wild-type ES cells, and this methylation was not detectably perturbed by the absence of Atrx (Figure S3 and unpublished data).
T3280 5719-5724 DT denotes These
T3281 5725-5732 NNS denotes repeats
T3282 5738-5743 VBN denotes found
T3283 5733-5737 VBD denotes were
T3284 5744-5746 TO denotes to
T3285 5747-5749 VB denotes be
T3286 5750-5760 RB denotes moderately
T3287 5832-5842 JJ denotes methylated
T3288 5761-5762 -LRB- denotes (
T3289 5762-5766 NN denotes Line
T3290 5767-5768 CD denotes 1
T3291 5769-5772 CC denotes and
T3292 5773-5777 NN denotes Sine
T3293 5778-5780 NN denotes B1
T3294 5780-5781 -RRB- denotes )
T3295 5782-5784 CC denotes or
T3296 5785-5791 RB denotes highly
T3297 5792-5793 -LRB- denotes (
T3298 5793-5796 NN denotes IAP
T3299 5796-5798 , denotes ,
T3300 5798-5803 JJ denotes major
T3301 5804-5813 NN denotes satellite
T3302 5813-5815 , denotes ,
T3303 5815-5820 JJ denotes minor
T3304 5821-5830 NN denotes satellite
T3305 5830-5831 -RRB- denotes )
T3306 5843-5845 IN denotes in
T3307 5846-5850 JJ denotes wild
T3308 5851-5855 NN denotes type
T3309 5850-5851 HYPH denotes -
T3310 5859-5864 NNS denotes cells
T3311 5856-5858 NN denotes ES
T3312 5864-5866 , denotes ,
T3313 5866-5869 CC denotes and
T3314 5870-5874 DT denotes this
T3315 5875-5886 NN denotes methylation
T3316 5906-5915 VBN denotes perturbed
T3317 5887-5890 VBD denotes was
T3318 5891-5894 RB denotes not
T3319 5895-5905 RB denotes detectably
T3320 5916-5918 IN denotes by
T3321 5919-5922 DT denotes the
T3322 5923-5930 NN denotes absence
T3323 5931-5933 IN denotes of
T3324 5934-5938 NN denotes Atrx
T3325 5939-5940 -LRB- denotes (
T3326 5947-5949 NN denotes S3
T3327 5940-5946 NN denotes Figure
T3328 5950-5953 CC denotes and
T3329 5954-5965 JJ denotes unpublished
T3330 5966-5970 NNS denotes data
T3331 5970-5971 -RRB- denotes )
T3332 5971-5972 . denotes .
T3333 5972-6138 sentence denotes Taken together, these data indicate that the subtle interplay between the ATRX protein and DNA methylation observed in human patients is also present in mouse cells.
T3334 5973-5978 VBN denotes Taken
T3335 6000-6008 VBP denotes indicate
T3336 5979-5987 RB denotes together
T3337 5987-5989 , denotes ,
T3338 5989-5994 DT denotes these
T3339 5995-5999 NNS denotes data
T3340 6009-6013 IN denotes that
T3341 6107-6109 VBZ denotes is
T3342 6014-6017 DT denotes the
T3343 6025-6034 NN denotes interplay
T3344 6018-6024 JJ denotes subtle
T3345 6035-6042 IN denotes between
T3346 6043-6046 DT denotes the
T3347 6052-6059 NN denotes protein
T3348 6047-6051 NN denotes ATRX
T3349 6060-6063 CC denotes and
T3350 6064-6067 NN denotes DNA
T3351 6068-6079 NN denotes methylation
T3352 6080-6088 VBN denotes observed
T3353 6089-6091 IN denotes in
T3354 6092-6097 JJ denotes human
T3355 6098-6106 NNS denotes patients
T3356 6110-6114 RB denotes also
T3357 6115-6122 JJ denotes present
T3358 6123-6125 IN denotes in
T3359 6126-6131 NN denotes mouse
T3360 6132-6137 NNS denotes cells
T3361 6137-6138 . denotes .
T2763 1271-1273 NN denotes ES
R1313 T2534 T2535 amod Perturbed,Growth
R1314 T2536 T2535 cc and,Growth
R1315 T2537 T2538 compound Methylation,Defects
R1316 T2538 T2535 conj Defects,Growth
R1317 T2539 T2535 prep in,Growth
R1318 T2540 T2541 amod Atrxnull,Cells
R1319 T2541 T2539 pobj Cells,in
R1320 T2542 T2541 compound ES,Cells
R1321 T2544 T2545 amod Atrxnull,cells
R1322 T2545 T2547 nsubjpass cells,maintained
R1323 T2546 T2545 compound ES,cells
R1324 T2548 T2547 aux could,maintained
R1325 T2549 T2547 auxpass be,maintained
R1326 T2550 T2547 prep in,maintained
R1327 T2551 T2550 pobj culture,in
R1328 T2552 T2547 cc but,maintained
R1329 T2553 T2547 conj were,maintained
R1330 T2554 T2553 advmod generally,were
R1331 T2555 T2556 advmod slower,growing
R1332 T2556 T2553 acomp growing,were
R1333 T2557 T2556 prep than,growing
R1334 T2558 T2559 nmod Atrx,ES
R1335 T2559 T2561 compound ES,clones
R1336 T2560 T2559 punct +,ES
R1337 T2561 T2557 pobj clones,than
R1338 T2562 T2553 punct ", ",were
R1339 T2563 T2553 cc and,were
R1340 T2564 T2553 conj appeared,were
R1341 T2565 T2566 aux to,undergo
R1342 T2566 T2564 xcomp undergo,appeared
R1343 T2567 T2568 amod higher,rates
R1344 T2568 T2566 dobj rates,undergo
R1345 T2569 T2568 prep of,rates
R1346 T2570 T2571 amod spontaneous,differentiation
R1347 T2571 T2569 pobj differentiation,of
R1348 T2572 T2547 punct .,maintained
R1349 T2574 T2575 nsubj We,investigated
R1350 T2576 T2575 advmod directly,investigated
R1351 T2577 T2578 det the,effect
R1352 T2578 T2575 dobj effect,investigated
R1353 T2579 T2578 prep of,effect
R1354 T2580 T2579 pobj Atrx,of
R1355 T2581 T2578 prep on,effect
R1356 T2582 T2583 compound ES,cell
R1357 T2583 T2584 compound cell,growth
R1358 T2584 T2581 pobj growth,on
R1359 T2585 T2575 prep by,investigated
R1360 T2586 T2585 pcomp comparing,by
R1361 T2587 T2588 nmod Atrx,clones
R1362 T2588 T2586 dobj clones,comparing
R1363 T2589 T2587 punct +,Atrx
R1364 T2590 T2587 cc and,Atrx
R1365 T2591 T2587 conj Atrxnull,Atrx
R1366 T2592 T2593 compound ES,cell
R1367 T2593 T2588 compound cell,clones
R1368 T2594 T2586 prep in,comparing
R1369 T2595 T2596 compound competition,cultures
R1370 T2596 T2594 pobj cultures,in
R1371 T2597 T2575 punct .,investigated
R1372 T2599 T2600 amod Equal,numbers
R1373 T2600 T2601 nsubjpass numbers,inoculated
R1374 T2602 T2600 prep of,numbers
R1375 T2603 T2604 nmod Atrx,cells
R1376 T2604 T2602 pobj cells,of
R1377 T2605 T2603 punct +,Atrx
R1378 T2606 T2603 punct (,Atrx
R1379 T2607 T2603 acl bearing,Atrx
R1380 T2608 T2609 preconj either,Atrx WT
R1381 T2609 T2607 dobj Atrx WT,bearing
R1382 T2610 T2609 det an,Atrx WT
R1383 T2611 T2609 cc or,Atrx WT
R1384 T2612 T2613 det an,Atrx flox
R1385 T2613 T2614 compound Atrx flox,allele
R1386 T2614 T2609 conj allele,Atrx WT
R1387 T2615 T2603 punct ),Atrx
R1388 T2616 T2603 cc and,Atrx
R1389 T2617 T2603 conj Atrxnull,Atrx
R1390 T2618 T2617 punct (,Atrxnull
R1391 T2619 T2617 acl bearing,Atrxnull
R1392 T2620 T2621 det an,allele
R1393 T2621 T2619 dobj allele,bearing
R1394 T2622 T2621 compound Atrx Δ18Δneo,allele
R1395 T2623 T2604 punct ),cells
R1396 T2624 T2604 compound ES,cells
R1397 T2625 T2601 auxpass were,inoculated
R1398 T2626 T2601 prep into,inoculated
R1399 T2627 T2626 pobj cultures,into
R1400 T2628 T2601 cc and,inoculated
R1401 T2629 T2630 det the,cultures
R1402 T2630 T2632 nsubjpass cultures,passaged
R1403 T2631 T2630 amod mixed,cultures
R1404 T2632 T2601 conj passaged,inoculated
R1405 T2633 T2632 auxpass were,passaged
R1406 T2634 T2635 punct (,split
R1407 T2635 T2632 parataxis split,passaged
R1408 T2636 T2635 nummod 1,split
R1409 T2637 T2638 punct :,3
R1410 T2638 T2636 prep 3,1
R1411 T2639 T2635 punct ),split
R1412 T2640 T2641 det every,d
R1413 T2641 T2632 npadvmod d,passaged
R1414 T2642 T2641 nummod 2,d
R1415 T2643 T2632 prep for,passaged
R1416 T2644 T2645 quantmod 8,10
R1417 T2645 T2647 nummod 10,d
R1418 T2646 T2645 punct –,10
R1419 T2647 T2643 pobj d,for
R1420 T2648 T2632 punct .,passaged
R1421 T2650 T2651 det The,abundance
R1422 T2651 T2653 nsubjpass abundance,analysed
R1423 T2652 T2651 amod relative,abundance
R1424 T2654 T2651 prep of,abundance
R1425 T2655 T2656 det the,alleles
R1426 T2656 T2654 pobj alleles,of
R1427 T2657 T2656 amod different,alleles
R1428 T2658 T2651 prep in,abundance
R1429 T2659 T2660 det the,culture
R1430 T2660 T2658 pobj culture,in
R1431 T2661 T2651 prep at,abundance
R1432 T2662 T2663 det each,point
R1433 T2663 T2661 pobj point,at
R1434 T2664 T2663 compound time,point
R1435 T2665 T2653 auxpass was,analysed
R1436 T2666 T2653 prep by,analysed
R1437 T2667 T2668 compound Southern,blotting
R1438 T2668 T2666 pobj blotting,by
R1439 T2669 T2670 punct (,3A
R1440 T2670 T2653 parataxis 3A,analysed
R1441 T2671 T2670 compound Figure,3A
R1442 T2672 T2670 punct ),3A
R1443 T2673 T2653 punct .,analysed
R1444 T2675 T2676 det The,clone
R1445 T2676 T2677 nsubjpass clone,outgrown
R1446 T2678 T2676 acl containing,clone
R1447 T2679 T2680 det the,allele
R1448 T2680 T2678 dobj allele,containing
R1449 T2681 T2680 compound Atrx Δ18Δneo,allele
R1450 T2682 T2677 auxpass was,outgrown
R1451 T2683 T2677 advmod rapidly,outgrown
R1452 T2684 T2677 agent by,outgrown
R1453 T2685 T2686 preconj both,cells
R1454 T2686 T2684 pobj cells,by
R1455 T2687 T2686 compound Atrx WT,cells
R1456 T2688 T2686 compound ES,cells
R1457 T2689 T2686 cc and,cells
R1458 T2690 T2686 conj cells,cells
R1459 T2691 T2690 acl bearing,cells
R1460 T2692 T2693 det the,allele
R1461 T2693 T2691 dobj allele,bearing
R1462 T2694 T2693 compound Atrx flox,allele
R1463 T2695 T2677 punct .,outgrown
R1464 T2697 T2698 prep In,continued
R1465 T2699 T2700 det a,experiment
R1466 T2700 T2697 pobj experiment,In
R1467 T2701 T2700 compound control,experiment
R1468 T2702 T2700 compound competition,experiment
R1469 T2703 T2700 prep between,experiment
R1470 T2704 T2705 amod different,clones
R1471 T2705 T2703 pobj clones,between
R1472 T2706 T2705 acl bearing,clones
R1473 T2707 T2708 amod functional,alleles
R1474 T2708 T2706 dobj alleles,bearing
R1475 T2709 T2708 compound Atrx,alleles
R1476 T2710 T2708 punct (,alleles
R1477 T2711 T2708 appos Atrx WT,alleles
R1478 T2712 T2711 cc and,Atrx WT
R1479 T2713 T2711 conj Atrx flox,Atrx WT
R1480 T2714 T2698 punct ),continued
R1481 T2715 T2698 punct ", ",continued
R1482 T2716 T2717 det both,clones
R1483 T2717 T2698 nsubj clones,continued
R1484 T2718 T2719 aux to,be
R1485 T2719 T2698 xcomp be,continued
R1486 T2720 T2721 advmod equally,represented
R1487 T2721 T2719 acomp represented,be
R1488 T2722 T2719 prep after,be
R1489 T2723 T2724 nummod 8,d
R1490 T2724 T2722 pobj d,after
R1491 T2725 T2724 prep of,d
R1492 T2726 T2725 pobj cocultivation,of
R1493 T2727 T2698 punct .,continued
R1494 T2729 T2730 advmod Thus,suggested
R1495 T2731 T2730 punct ", ",suggested
R1496 T2732 T2733 mark although,recovered
R1497 T2733 T2730 advcl recovered,suggested
R1498 T2734 T2735 amod Atrxnull,cells
R1499 T2735 T2733 nsubj cells,recovered
R1500 T2736 T2735 compound ES,cells
R1501 T2737 T2733 aux could,recovered
R1502 T2738 T2733 aux be,recovered
R1503 T2739 T2733 cc and,recovered
R1504 T2740 T2733 conj maintained,recovered
R1505 T2741 T2740 prep in,maintained
R1506 T2742 T2741 pobj culture,in
R1507 T2743 T2733 prep by,recovered
R1508 T2744 T2745 det a,approach
R1509 T2745 T2743 pobj approach,by
R1510 T2746 T2747 amod conditional,targeting
R1511 T2747 T2745 compound targeting,approach
R1512 T2748 T2730 punct ", ",suggested
R1513 T2749 T2750 det these,experiments
R1514 T2750 T2730 nsubj experiments,suggested
R1515 T2751 T2750 compound cocultivation,experiments
R1516 T2752 T2753 mark that,impact
R1517 T2753 T2730 ccomp impact,suggested
R1518 T2754 T2755 det the,absence
R1519 T2755 T2753 nsubj absence,impact
R1520 T2756 T2755 prep of,absence
R1521 T2757 T2756 pobj Atrx,of
R1522 T2758 T2753 aux does,impact
R1523 T2759 T2753 advmod negatively,impact
R1524 T2760 T2753 prep upon,impact
R1525 T2761 T2762 amod normal,growth
R1526 T2762 T2760 pobj growth,upon
R1527 T2763 T2764 compound ES,cell
R1528 T2764 T2762 compound cell,growth
R1529 T2765 T2730 punct .,suggested
R1530 T2767 T2768 aux To,investigate
R1531 T2768 T2769 advcl investigate,analysed
R1532 T2770 T2771 det a,defect
R1533 T2771 T2768 dobj defect,investigate
R1534 T2772 T2771 amod possible,defect
R1535 T2773 T2774 compound cell,cycle
R1536 T2774 T2771 compound cycle,defect
R1537 T2775 T2774 punct -,cycle
R1538 T2776 T2771 prep in,defect
R1539 T2777 T2778 det the,absence
R1540 T2778 T2776 pobj absence,in
R1541 T2779 T2778 prep of,absence
R1542 T2780 T2779 pobj Atrx,of
R1543 T2781 T2769 punct ", ",analysed
R1544 T2782 T2769 nsubj we,analysed
R1545 T2783 T2784 det the,distribution
R1546 T2784 T2769 dobj distribution,analysed
R1547 T2785 T2786 compound cell,cycle
R1548 T2786 T2784 compound cycle,distribution
R1549 T2787 T2784 prep of,distribution
R1550 T2788 T2789 npadvmod bromodeoxyuridine,pulsed
R1551 T2789 T2794 amod pulsed,cells
R1552 T2790 T2788 punct (,bromodeoxyuridine
R1553 T2791 T2788 appos BrdU,bromodeoxyuridine
R1554 T2792 T2789 punct ),pulsed
R1555 T2793 T2789 punct -,pulsed
R1556 T2794 T2787 pobj cells,of
R1557 T2795 T2794 compound ES,cells
R1558 T2796 T2769 prep by,analysed
R1559 T2797 T2798 compound flow,cytometry
R1560 T2798 T2796 pobj cytometry,by
R1561 T2799 T2800 punct (,S1A
R1562 T2800 T2769 parataxis S1A,analysed
R1563 T2801 T2800 compound Figure,S1A
R1564 T2802 T2800 punct ),S1A
R1565 T2803 T2769 punct .,analysed
R1566 T2805 T2806 advmod Surprisingly,exhibited
R1567 T2807 T2806 punct ", ",exhibited
R1568 T2808 T2809 det both,clones
R1569 T2809 T2806 nsubj clones,exhibited
R1570 T2810 T2811 amod Atrxnull,cell
R1571 T2811 T2809 compound cell,clones
R1572 T2812 T2811 compound ES,cell
R1573 T2813 T2814 det a,profile
R1574 T2814 T2806 dobj profile,exhibited
R1575 T2815 T2816 compound cell,cycle
R1576 T2816 T2814 compound cycle,profile
R1577 T2817 T2818 dep that,was
R1578 T2818 T2814 relcl was,profile
R1579 T2819 T2818 acomp indistinguishable,was
R1580 T2820 T2819 prep from,indistinguishable
R1581 T2821 T2822 compound ES,cells
R1582 T2822 T2820 pobj cells,from
R1583 T2823 T2822 acl bearing,cells
R1584 T2824 T2825 det a,allele
R1585 T2825 T2823 dobj allele,bearing
R1586 T2826 T2825 amod functional,allele
R1587 T2827 T2825 compound Atrx,allele
R1588 T2828 T2825 punct (,allele
R1589 T2829 T2825 appos Atrx WT,allele
R1590 T2830 T2829 cc or,Atrx WT
R1591 T2831 T2829 conj Atrx flox,Atrx WT
R1592 T2832 T2806 punct ),exhibited
R1593 T2833 T2806 punct .,exhibited
R1594 T2835 T2836 nsubj We,quantitated
R1595 T2837 T2836 advmod also,quantitated
R1596 T2838 T2836 advmod specifically,quantitated
R1597 T2839 T2840 det the,index
R1598 T2840 T2836 dobj index,quantitated
R1599 T2841 T2840 amod mitotic,index
R1600 T2842 T2840 prep within,index
R1601 T2843 T2844 det each,population
R1602 T2844 T2842 pobj population,within
R1603 T2845 T2836 prep by,quantitated
R1604 T2846 T2847 compound flow,cytometry
R1605 T2847 T2845 pobj cytometry,by
R1606 T2848 T2836 prep after,quantitated
R1607 T2849 T2848 pcomp staining,after
R1608 T2850 T2851 compound ES,cells
R1609 T2851 T2849 dobj cells,staining
R1610 T2852 T2849 prep for,staining
R1611 T2853 T2854 amod phosphorylated,H3
R1612 T2854 T2852 pobj H3,for
R1613 T2855 T2856 punct (,Ser10
R1614 T2856 T2853 parataxis Ser10,phosphorylated
R1615 T2857 T2856 punct ),Ser10
R1616 T2858 T2854 compound histone,H3
R1617 T2859 T2854 punct ", ",H3
R1618 T2860 T2861 det a,marker
R1619 T2861 T2854 appos marker,H3
R1620 T2862 T2861 amod specific,marker
R1621 T2863 T2861 prep of,marker
R1622 T2864 T2863 pobj mitosis,of
R1623 T2865 T2866 punct (,S1B
R1624 T2866 T2836 parataxis S1B,quantitated
R1625 T2867 T2866 compound Figure,S1B
R1626 T2868 T2866 punct ),S1B
R1627 T2869 T2870 punct [,13
R1628 T2870 T2836 parataxis 13,quantitated
R1629 T2871 T2870 punct ],13
R1630 T2872 T2836 punct .,quantitated
R1631 T2874 T2875 advcl Consistent,was
R1632 T2876 T2874 prep with,Consistent
R1633 T2877 T2878 det the,profile
R1634 T2878 T2876 pobj profile,with
R1635 T2879 T2878 amod normal,profile
R1636 T2880 T2881 compound cell,cycle
R1637 T2881 T2878 compound cycle,profile
R1638 T2882 T2881 punct -,cycle
R1639 T2883 T2878 acl observed,profile
R1640 T2884 T2883 advmod above,observed
R1641 T2885 T2875 punct ", ",was
R1642 T2886 T2875 expl there,was
R1643 T2887 T2888 det no,depletion
R1644 T2888 T2875 attr depletion,was
R1645 T2889 T2888 prep in,depletion
R1646 T2890 T2891 det the,size
R1647 T2891 T2889 pobj size,in
R1648 T2892 T2891 prep of,size
R1649 T2893 T2894 det the,population
R1650 T2894 T2892 pobj population,of
R1651 T2895 T2894 amod mitotic,population
R1652 T2896 T2875 prep in,was
R1653 T2897 T2898 det the,clones
R1654 T2898 T2896 pobj clones,in
R1655 T2899 T2898 amod Atrxnull,clones
R1656 T2900 T2898 compound ES,clones
R1657 T2901 T2875 punct ", ",was
R1658 T2902 T2875 prep despite,was
R1659 T2903 T2904 poss their,growth
R1660 T2904 T2902 pobj growth,despite
R1661 T2905 T2904 amod slow,growth
R1662 T2906 T2875 punct .,was
R1663 T2908 T2909 advmod Finally,investigated
R1664 T2910 T2909 punct ", ",investigated
R1665 T2911 T2909 nsubj we,investigated
R1666 T2912 T2913 mark whether,was
R1667 T2913 T2909 ccomp was,investigated
R1668 T2914 T2915 det the,defect
R1669 T2915 T2913 nsubj defect,was
R1670 T2916 T2915 compound growth,defect
R1671 T2917 T2915 prep in,defect
R1672 T2918 T2919 det the,cells
R1673 T2919 T2917 pobj cells,in
R1674 T2920 T2921 amod Atrxnull,ES
R1675 T2921 T2919 compound ES,cells
R1676 T2922 T2913 prep due,was
R1677 T2923 T2922 pcomp to,due
R1678 T2924 T2925 det an,regulation
R1679 T2925 T2922 pobj regulation,due
R1680 T2926 T2925 amod up,regulation
R1681 T2927 T2925 punct -,regulation
R1682 T2928 T2925 prep of,regulation
R1683 T2929 T2928 pobj apoptosis,of
R1684 T2930 T2909 prep by,investigated
R1685 T2931 T2930 pcomp staining,by
R1686 T2932 T2931 dobj cells,staining
R1687 T2933 T2931 prep with,staining
R1688 T2934 T2933 pobj Annexin,with
R1689 T2935 T2934 nummod V,Annexin
R1690 T2936 T2937 punct (,S2
R1691 T2937 T2909 parataxis S2,investigated
R1692 T2938 T2937 compound Figure,S2
R1693 T2939 T2937 punct ),S2
R1694 T2940 T2909 cc and,investigated
R1695 T2941 T2909 conj found,investigated
R1696 T2942 T2943 mark that,affected
R1697 T2943 T2941 ccomp affected,found
R1698 T2944 T2945 det the,proportion
R1699 T2945 T2943 nsubjpass proportion,affected
R1700 T2946 T2945 prep of,proportion
R1701 T2947 T2948 amod apoptotic,cells
R1702 T2948 T2946 pobj cells,of
R1703 T2949 T2943 auxpass was,affected
R1704 T2950 T2943 neg not,affected
R1705 T2951 T2943 advmod significantly,affected
R1706 T2952 T2943 agent by,affected
R1707 T2953 T2954 det the,absence
R1708 T2954 T2952 pobj absence,by
R1709 T2955 T2954 prep of,absence
R1710 T2956 T2957 amod full,length
R1711 T2957 T2959 compound length,Atrx
R1712 T2958 T2957 punct -,length
R1713 T2959 T2955 pobj Atrx,of
R1714 T2960 T2909 punct .,investigated
R1715 T2962 T2963 advmod Thus,is
R1716 T2964 T2963 punct ", ",is
R1717 T2965 T2966 det the,defect
R1718 T2966 T2963 nsubj defect,is
R1719 T2967 T2966 compound growth,defect
R1720 T2968 T2966 acl observed,defect
R1721 T2969 T2968 prep in,observed
R1722 T2970 T2971 compound ES,cells
R1723 T2971 T2969 pobj cells,in
R1724 T2972 T2971 acl lacking,cells
R1725 T2973 T2972 dobj Atrx,lacking
R1726 T2974 T2963 neg not,is
R1727 T2975 T2963 prep due,is
R1728 T2976 T2975 pcomp to,due
R1729 T2977 T2978 det a,block
R1730 T2978 T2975 pobj block,due
R1731 T2979 T2978 amod specific,block
R1732 T2980 T2981 compound cell,cycle
R1733 T2981 T2978 compound cycle,block
R1734 T2982 T2978 cc or,block
R1735 T2983 T2984 amod significant,induction
R1736 T2984 T2978 conj induction,block
R1737 T2985 T2984 prep of,induction
R1738 T2986 T2987 compound cell,death
R1739 T2987 T2985 pobj death,of
R1740 T2988 T2963 punct .,is
R1741 T2990 T2991 mark While,is
R1742 T2991 T2998 advcl is,seems
R1743 T2992 T2993 det the,cause
R1744 T2993 T2991 nsubj cause,is
R1745 T2994 T2993 prep of,cause
R1746 T2995 T2996 det the,delay
R1747 T2996 T2994 pobj delay,of
R1748 T2997 T2996 amod proliferative,delay
R1749 T2999 T2991 neg not,is
R1750 T3000 T2991 advmod yet,is
R1751 T3001 T2991 acomp clear,is
R1752 T3002 T2991 punct ", ",is
R1753 T3003 T3004 mark since,appear
R1754 T3004 T2991 advcl appear,is
R1755 T3005 T3006 amod Atrxnull,cells
R1756 T3006 T3004 nsubj cells,appear
R1757 T3007 T3006 compound ES,cells
R1758 T3008 T3009 aux to,undergo
R1759 T3009 T3004 xcomp undergo,appear
R1760 T3010 T3011 amod higher,rates
R1761 T3011 T3009 dobj rates,undergo
R1762 T3012 T3011 prep of,rates
R1763 T3013 T3014 amod spontaneous,differentiation
R1764 T3014 T3012 pobj differentiation,of
R1765 T3015 T3016 punct (,data
R1766 T3016 T2991 meta data,is
R1767 T3017 T3016 amod unpublished,data
R1768 T3018 T3016 punct ),data
R1769 T3019 T2998 punct ", ",seems
R1770 T3020 T2998 nsubj it,seems
R1771 T3021 T2998 oprd likely,seems
R1772 T3022 T3023 mark that,reflects
R1773 T3023 T2998 ccomp reflects,seems
R1774 T3024 T3025 det the,defect
R1775 T3025 T3023 nsubj defect,reflects
R1776 T3026 T3025 amod observed,defect
R1777 T3027 T3025 compound growth,defect
R1778 T3028 T3029 det the,transition
R1779 T3029 T3023 dobj transition,reflects
R1780 T3030 T3029 amod spontaneous,transition
R1781 T3031 T3029 prep from,transition
R1782 T3032 T3033 advmod fast,cycling
R1783 T3033 T3035 amod cycling,cells
R1784 T3034 T3033 punct -,cycling
R1785 T3035 T3031 pobj cells,from
R1786 T3036 T3035 punct ", ",cells
R1787 T3037 T3035 amod undifferentiated,cells
R1788 T3038 T3035 compound ES,cells
R1789 T3039 T3029 prep into,transition
R1790 T3040 T3041 advmod more,slowly
R1791 T3041 T3042 advmod slowly,cycling
R1792 T3042 T3043 amod cycling,types
R1793 T3043 T3039 pobj types,into
R1794 T3044 T3043 punct ", ",types
R1795 T3045 T3043 amod differentiated,types
R1796 T3046 T3043 compound cell,types
R1797 T3047 T3023 prep in,reflects
R1798 T3048 T3049 det these,cultures
R1799 T3049 T3047 pobj cultures,in
R1800 T3050 T2998 punct .,seems
R1801 T3052 T3053 nsubjpass It,shown
R1802 T3054 T3053 aux has,shown
R1803 T3055 T3053 auxpass been,shown
R1804 T3056 T3057 mark that,give
R1805 T3057 T3053 ccomp give,shown
R1806 T3058 T3059 npadvmod disease,causing
R1807 T3059 T3061 amod causing,mutations
R1808 T3060 T3059 punct -,causing
R1809 T3061 T3057 nsubj mutations,give
R1810 T3062 T3061 prep in,mutations
R1811 T3063 T3064 det the,gene
R1812 T3064 T3062 pobj gene,in
R1813 T3065 T3064 amod human,gene
R1814 T3066 T3064 compound ATRX,gene
R1815 T3067 T3057 dobj rise,give
R1816 T3068 T3057 prep to,give
R1817 T3069 T3068 pobj changes,to
R1818 T3070 T3069 prep in,changes
R1819 T3071 T3072 det the,pattern
R1820 T3072 T3070 pobj pattern,in
R1821 T3073 T3072 amod normal,pattern
R1822 T3074 T3072 prep of,pattern
R1823 T3075 T3076 compound DNA,methylation
R1824 T3076 T3074 pobj methylation,of
R1825 T3077 T3069 prep at,changes
R1826 T3078 T3079 amod several,sequences
R1827 T3079 T3077 pobj sequences,at
R1828 T3080 T3079 amod repetitive,sequences
R1829 T3081 T3079 prep within,sequences
R1830 T3082 T3083 det the,genome
R1831 T3083 T3081 pobj genome,within
R1832 T3084 T3083 amod human,genome
R1833 T3085 T3086 punct [,11
R1834 T3086 T3057 parataxis 11,give
R1835 T3087 T3086 punct ],11
R1836 T3088 T3053 punct .,shown
R1837 T3090 T3091 advmod Notably,found
R1838 T3092 T3091 punct ", ",found
R1839 T3093 T3094 det the,region
R1840 T3094 T3091 nsubjpass region,found
R1841 T3095 T3094 amod transcribed,region
R1842 T3096 T3094 prep of,region
R1843 T3097 T3098 det the,repeat
R1844 T3098 T3096 pobj repeat,of
R1845 T3099 T3100 amod ribosomal,DNA
R1846 T3100 T3098 nmod DNA,repeat
R1847 T3101 T3100 punct (,DNA
R1848 T3102 T3100 appos rDNA,DNA
R1849 T3103 T3098 punct ),repeat
R1850 T3104 T3091 auxpass was,found
R1851 T3105 T3106 aux to,hypomethylated
R1852 T3106 T3091 xcomp hypomethylated,found
R1853 T3107 T3106 auxpass be,hypomethylated
R1854 T3108 T3106 advmod significantly,hypomethylated
R1855 T3109 T3106 prep in,hypomethylated
R1856 T3110 T3111 compound ATR,X
R1857 T3111 T3113 compound X,patients
R1858 T3112 T3111 punct -,X
R1859 T3113 T3109 pobj patients,in
R1860 T3114 T3106 advcl relative,hypomethylated
R1861 T3115 T3114 prep to,relative
R1862 T3116 T3117 amod normal,individuals
R1863 T3117 T3115 pobj individuals,to
R1864 T3118 T3091 punct .,found
R1865 T3120 T3121 advcl Using,observed
R1866 T3122 T3123 npadvmod methylation,sensitive
R1867 T3123 T3125 amod sensitive,enzymes
R1868 T3124 T3123 punct -,sensitive
R1869 T3125 T3120 dobj enzymes,Using
R1870 T3126 T3125 compound restriction,enzymes
R1871 T3127 T3121 punct ", ",observed
R1872 T3128 T3121 nsubj we,observed
R1873 T3129 T3121 advmod also,observed
R1874 T3130 T3131 amod significant,hypomethylation
R1875 T3131 T3121 dobj hypomethylation,observed
R1876 T3132 T3121 prep at,observed
R1877 T3133 T3134 amod several,sites
R1878 T3134 T3132 pobj sites,at
R1879 T3135 T3134 acl tested,sites
R1880 T3136 T3135 prep within,tested
R1881 T3137 T3138 det the,repeats
R1882 T3138 T3136 pobj repeats,within
R1883 T3139 T3140 compound mouse,rDNA
R1884 T3140 T3138 compound rDNA,repeats
R1885 T3141 T3138 prep in,repeats
R1886 T3142 T3143 amod Atrxnull,cells
R1887 T3143 T3141 pobj cells,in
R1888 T3144 T3143 compound ES,cells
R1889 T3145 T3143 cc and,cells
R1890 T3146 T3147 nummod 12,d
R1891 T3147 T3149 nmod d,bodies
R1892 T3148 T3147 punct -,d
R1893 T3149 T3143 conj bodies,cells
R1894 T3150 T3149 amod embryoid,bodies
R1895 T3151 T3121 advcl relative,observed
R1896 T3152 T3151 prep to,relative
R1897 T3153 T3154 compound ES,cells
R1898 T3154 T3152 pobj cells,to
R1899 T3155 T3154 cc and,cells
R1900 T3156 T3157 amod embryoid,bodies
R1901 T3157 T3154 conj bodies,cells
R1902 T3158 T3154 acl bearing,cells
R1903 T3159 T3160 det a,allele
R1904 T3160 T3158 dobj allele,bearing
R1905 T3161 T3160 amod functional,allele
R1906 T3162 T3160 compound Atrx,allele
R1907 T3163 T3160 punct (,allele
R1908 T3164 T3160 appos Atrx WT,allele
R1909 T3165 T3164 cc or,Atrx WT
R1910 T3166 T3164 conj Atrx flox,Atrx WT
R1911 T3167 T3121 punct ),observed
R1912 T3168 T3169 punct (,3B
R1913 T3169 T3121 parataxis 3B,observed
R1914 T3170 T3169 compound Figure,3B
R1915 T3171 T3169 cc and,3B
R1916 T3172 T3169 conj 3C,3B
R1917 T3173 T3169 punct ),3B
R1918 T3174 T3121 punct .,observed
R1919 T3176 T3177 det The,observation
R1920 T3177 T3178 nsubj observation,is
R1921 T3179 T3180 mark that,hypomethylated
R1922 T3180 T3177 acl hypomethylated,observation
R1923 T3181 T3180 nsubjpass rDNA,hypomethylated
R1924 T3182 T3180 auxpass is,hypomethylated
R1925 T3183 T3180 prep in,hypomethylated
R1926 T3184 T3185 det the,absence
R1927 T3185 T3183 pobj absence,in
R1928 T3186 T3185 prep of,absence
R1929 T3187 T3186 pobj Atrx,of
R1930 T3188 T3180 punct ", ",hypomethylated
R1931 T3189 T3190 advmod even,in
R1932 T3190 T3180 prep in,hypomethylated
R1933 T3191 T3192 compound ES,cells
R1934 T3192 T3190 pobj cells,in
R1935 T3193 T3178 punct ", ",is
R1936 T3194 T3178 acomp consistent,is
R1937 T3195 T3194 prep with,consistent
R1938 T3196 T3197 det the,finding
R1939 T3197 T3195 pobj finding,with
R1940 T3198 T3199 mark that,is
R1941 T3199 T3197 acl is,finding
R1942 T3200 T3199 nsubj hypomethylation,is
R1943 T3201 T3200 prep of,hypomethylation
R1944 T3202 T3203 det the,repeats
R1945 T3203 T3201 pobj repeats,of
R1946 T3204 T3205 amod human,rDNA
R1947 T3205 T3203 compound rDNA,repeats
R1948 T3206 T3199 acomp detectable,is
R1949 T3207 T3199 prep from,is
R1950 T3208 T3209 det an,stage
R1951 T3209 T3207 pobj stage,from
R1952 T3210 T3209 amod early,stage
R1953 T3211 T3209 amod developmental,stage
R1954 T3212 T3199 prep in,is
R1955 T3213 T3214 compound ATR,X
R1956 T3214 T3216 compound X,patients
R1957 T3215 T3214 punct -,X
R1958 T3216 T3212 pobj patients,in
R1959 T3217 T3178 punct .,is
R1960 T3219 T3220 amod Other,elements
R1961 T3220 T3224 nsubj elements,include
R1962 T3221 T3220 nmod mouse,elements
R1963 T3222 T3223 amod repetitive,sequence
R1964 T3223 T3220 compound sequence,elements
R1965 T3225 T3220 acl surveyed,elements
R1966 T3226 T3225 prep in,surveyed
R1967 T3227 T3228 compound ES,DNA
R1968 T3228 T3226 pobj DNA,in
R1969 T3229 T3228 compound cell,DNA
R1970 T3230 T3231 det the,repeats
R1971 T3231 T3224 dobj repeats,include
R1972 T3232 T3233 amod heterochromatic,satellite
R1973 T3233 T3231 nmod satellite,repeats
R1974 T3234 T3233 amod major,satellite
R1975 T3235 T3236 punct (,assayed
R1976 T3236 T3233 parataxis assayed,satellite
R1977 T3237 T3236 prep with,assayed
R1978 T3238 T3237 pobj MaeII,with
R1979 T3239 T3236 punct ),assayed
R1980 T3240 T3233 cc and,satellite
R1981 T3241 T3242 amod minor,satellite
R1982 T3242 T3233 conj satellite,satellite
R1983 T3243 T3244 punct (,assayed
R1984 T3244 T3242 parataxis assayed,satellite
R1985 T3245 T3244 prep with,assayed
R1986 T3246 T3245 pobj HpaII,with
R1987 T3247 T3244 punct ),assayed
R1988 T3248 T3231 punct ", ",repeats
R1989 T3249 T3250 advmod as,as
R1990 T3250 T3231 cc as,repeats
R1991 T3251 T3250 advmod well,as
R1992 T3252 T3253 amod interspersed,repeats
R1993 T3253 T3231 conj repeats,repeats
R1994 T3254 T3253 amod retroviral,repeats
R1995 T3255 T3253 prep of,repeats
R1996 T3256 T3257 det the,type
R1997 T3257 T3255 pobj type,of
R1998 T3258 T3259 amod intracisternal,particle
R1999 T3259 T3257 nmod particle,type
R2000 T3260 T3259 nmod A,particle
R2001 T3261 T3259 punct (,particle
R2002 T3262 T3259 appos IAP,particle
R2003 T3263 T3257 punct ),type
R2004 T3264 T3257 cc and,type
R2005 T3265 T3266 det the,families
R2006 T3266 T3257 conj families,type
R2007 T3267 T3266 nmod Line,families
R2008 T3268 T3267 nummod 1,Line
R2009 T3269 T3267 cc and,Line
R2010 T3270 T3271 compound Sine,B1
R2011 T3271 T3267 conj B1,Line
R2012 T3272 T3273 punct (,all
R2013 T3273 T3266 parataxis all,families
R2014 T3274 T3273 acl assayed,all
R2015 T3275 T3274 prep with,assayed
R2016 T3276 T3275 pobj HpaII,with
R2017 T3277 T3273 punct ),all
R2018 T3278 T3224 punct .,include
R2019 T3280 T3281 det These,repeats
R2020 T3281 T3282 nsubjpass repeats,found
R2021 T3283 T3282 auxpass were,found
R2022 T3284 T3285 aux to,be
R2023 T3285 T3282 xcomp be,found
R2024 T3286 T3287 advmod moderately,methylated
R2025 T3287 T3285 acomp methylated,be
R2026 T3288 T3289 punct (,Line
R2027 T3289 T3286 parataxis Line,moderately
R2028 T3290 T3289 nummod 1,Line
R2029 T3291 T3289 cc and,Line
R2030 T3292 T3293 compound Sine,B1
R2031 T3293 T3289 conj B1,Line
R2032 T3294 T3289 punct ),Line
R2033 T3295 T3286 cc or,moderately
R2034 T3296 T3286 conj highly,moderately
R2035 T3297 T3298 punct (,IAP
R2036 T3298 T3296 parataxis IAP,highly
R2037 T3299 T3298 punct ", ",IAP
R2038 T3300 T3301 amod major,satellite
R2039 T3301 T3298 appos satellite,IAP
R2040 T3302 T3298 punct ", ",IAP
R2041 T3303 T3304 amod minor,satellite
R2042 T3304 T3298 appos satellite,IAP
R2043 T3305 T3298 punct ),IAP
R2044 T3306 T3285 prep in,be
R2045 T3307 T3308 amod wild,type
R2046 T3308 T3310 compound type,cells
R2047 T3309 T3308 punct -,type
R2048 T3310 T3306 pobj cells,in
R2049 T3311 T3310 compound ES,cells
R2050 T3312 T3282 punct ", ",found
R2051 T3313 T3282 cc and,found
R2052 T3314 T3315 det this,methylation
R2053 T3315 T3316 nsubjpass methylation,perturbed
R2054 T3316 T3282 conj perturbed,found
R2055 T3317 T3316 auxpass was,perturbed
R2056 T3318 T3316 neg not,perturbed
R2057 T3319 T3316 advmod detectably,perturbed
R2058 T3320 T3316 agent by,perturbed
R2059 T3321 T3322 det the,absence
R2060 T3322 T3320 pobj absence,by
R2061 T3323 T3322 prep of,absence
R2062 T3324 T3323 pobj Atrx,of
R2063 T3325 T3326 punct (,S3
R2064 T3326 T3316 parataxis S3,perturbed
R2065 T3327 T3326 compound Figure,S3
R2066 T3328 T3326 cc and,S3
R2067 T3329 T3330 amod unpublished,data
R2068 T3330 T3326 conj data,S3
R2069 T3331 T3326 punct ),S3
R2070 T3332 T3316 punct .,perturbed
R2071 T3334 T3335 advcl Taken,indicate
R2072 T3336 T3334 advmod together,Taken
R2073 T3337 T3335 punct ", ",indicate
R2074 T3338 T3339 det these,data
R2075 T3339 T3335 nsubj data,indicate
R2076 T3340 T3341 mark that,is
R2077 T3341 T3335 ccomp is,indicate
R2078 T3342 T3343 det the,interplay
R2079 T3343 T3341 nsubj interplay,is
R2080 T3344 T3343 amod subtle,interplay
R2081 T3345 T3343 prep between,interplay
R2082 T3346 T3347 det the,protein
R2083 T3347 T3345 pobj protein,between
R2084 T3348 T3347 compound ATRX,protein
R2085 T3349 T3347 cc and,protein
R2086 T3350 T3351 compound DNA,methylation
R2087 T3351 T3347 conj methylation,protein
R2088 T3352 T3343 acl observed,interplay
R2089 T3353 T3352 prep in,observed
R2090 T3354 T3355 amod human,patients
R2091 T3355 T3353 pobj patients,in
R2092 T3356 T3341 advmod also,is
R2093 T3357 T3341 acomp present,is
R2094 T3358 T3341 prep in,is
R2095 T3359 T3360 compound mouse,cells
R2096 T3360 T3358 pobj cells,in
R2097 T3361 T3335 punct .,indicate

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2322 10-16 GO_EXT:biological_growth_entity_or_process denotes Growth
T2323 21-32 GO_MOP_EXT:methylation denotes Methylation
T2324 44-48 PR_EXT:000004503 denotes Atrx
T2325 48-52 SO_EXT:sequence_nullness denotes null
T2326 53-61 CL:0002322 denotes ES Cells
T2327 56-61 CL_GO_EXT:cell denotes Cells
T2328 62-66 PR_EXT:000004503 denotes Atrx
T2329 66-70 SO_EXT:sequence_nullness denotes null
T2330 71-79 CL:0002322 denotes ES cells
T2331 74-79 CL_GO_EXT:cell denotes cells
T2332 137-144 GO:0040007 denotes growing
T2333 150-154 PR_EXT:000004503 denotes Atrx
T2334 156-158 CL:0002322 denotes ES
T2335 159-165 SO_EXT:sequence_cloned_entity denotes clones
T2336 219-234 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T2337 275-279 PR_EXT:000004503 denotes Atrx
T2338 283-290 CL:0002322 denotes ES cell
T2339 286-290 CL_GO_EXT:cell denotes cell
T2340 291-297 GO_EXT:biological_growth_entity_or_process denotes growth
T2341 311-315 PR_EXT:000004503 denotes Atrx
T2342 321-325 PR_EXT:000004503 denotes Atrx
T2343 325-329 SO_EXT:sequence_nullness denotes null
T2344 330-337 CL:0002322 denotes ES cell
T2345 333-337 CL_GO_EXT:cell denotes cell
T2346 338-344 SO_EXT:sequence_cloned_entity denotes clones
T2347 387-391 PR_EXT:000004503 denotes Atrx
T2348 412-416 PR_EXT:000004503 denotes Atrx
T2349 417-419 SO_EXT:wild_type_entity_or_quality denotes WT
T2350 426-430 PR_EXT:000004503 denotes Atrx
T2351 431-435 SO:0000359 denotes flox
T2352 436-442 SO_EXT:0001023 denotes allele
T2353 448-452 PR_EXT:000004503 denotes Atrx
T2354 452-456 SO_EXT:sequence_nullness denotes null
T2355 469-473 PR_EXT:000004503 denotes Atrx
T2356 482-488 SO_EXT:0001023 denotes allele
T2357 490-498 CL:0002322 denotes ES cells
T2358 493-498 CL_GO_EXT:cell denotes cells
T2359 640-647 SO_EXT:0001023 denotes alleles
T2360 733-738 SO_EXT:sequence_cloned_entity denotes clone
T2361 754-758 PR_EXT:000004503 denotes Atrx
T2362 767-773 SO_EXT:0001023 denotes allele
T2363 803-807 PR_EXT:000004503 denotes Atrx
T2364 808-810 SO_EXT:wild_type_entity_or_quality denotes WT
T2365 811-819 CL:0002322 denotes ES cells
T2366 814-819 CL_GO_EXT:cell denotes cells
T2367 824-829 CL_GO_EXT:cell denotes cells
T2368 842-846 PR_EXT:000004503 denotes Atrx
T2369 847-851 SO:0000359 denotes flox
T2370 852-858 SO_EXT:0001023 denotes allele
T2371 914-920 SO_EXT:sequence_cloned_entity denotes clones
T2372 940-944 PR_EXT:000004503 denotes Atrx
T2373 945-952 SO_EXT:0001023 denotes alleles
T2374 954-958 PR_EXT:000004503 denotes Atrx
T2375 959-961 SO_EXT:wild_type_entity_or_quality denotes WT
T2376 966-970 PR_EXT:000004503 denotes Atrx
T2377 971-975 SO:0000359 denotes flox
T2378 983-989 SO_EXT:sequence_cloned_entity denotes clones
T2379 1069-1073 PR_EXT:000004503 denotes Atrx
T2380 1073-1077 SO_EXT:sequence_nullness denotes null
T2381 1078-1086 CL:0002322 denotes ES cells
T2382 1081-1086 CL_GO_EXT:cell denotes cells
T2383 1231-1235 PR_EXT:000004503 denotes Atrx
T2384 1271-1278 CL:0002322 denotes ES cell
T2385 1274-1278 CL_GO_EXT:cell denotes cell
T2386 1279-1285 GO_EXT:biological_growth_entity_or_process denotes growth
T2387 2995-2999 CL_GO_EXT:cell denotes cell
T2388 2995-3005 GO:0007049 denotes cell-cycle
T2389 3031-3035 PR_EXT:000004503 denotes Atrx
T2390 3053-3057 CL_GO_EXT:cell denotes cell
T2391 3053-3063 GO:0007049 denotes cell cycle
T2392 3080-3097 CHEBI:472552 denotes bromodeoxyuridine
T2393 3099-3103 CHEBI:472552 denotes BrdU
T2394 3112-3120 CL:0002322 denotes ES cells
T2395 3115-3120 CL_GO_EXT:cell denotes cells
T2396 3172-3176 PR_EXT:000004503 denotes Atrx
T2397 3176-3180 SO_EXT:sequence_nullness denotes null
T2398 3181-3188 CL:0002322 denotes ES cell
T2399 3184-3188 CL_GO_EXT:cell denotes cell
T2400 3189-3195 SO_EXT:sequence_cloned_entity denotes clones
T2401 3208-3212 CL_GO_EXT:cell denotes cell
T2402 3208-3218 GO:0007049 denotes cell cycle
T2403 3259-3267 CL:0002322 denotes ES cells
T2404 3262-3267 CL_GO_EXT:cell denotes cells
T2405 3289-3293 PR_EXT:000004503 denotes Atrx
T2406 3294-3300 SO_EXT:0001023 denotes allele
T2407 3302-3306 PR_EXT:000004503 denotes Atrx
T2408 3307-3309 SO_EXT:wild_type_entity_or_quality denotes WT
T2409 3313-3317 PR_EXT:000004503 denotes Atrx
T2410 3318-3322 SO:0000359 denotes flox
T2411 3362-3369 GO:0007067 denotes mitotic
T2412 3432-3440 CL:0002322 denotes ES cells
T2413 3435-3440 CL_GO_EXT:cell denotes cells
T2414 3445-3459 GO_PATO_EXT:phosphorylation_process_or_quality denotes phosphorylated
T2415 3468-3475 CHEBI:15358 denotes histone
T2416 3468-3478 PR_EXT:000027594 denotes histone H3
T2417 3491-3497 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T2418 3501-3508 GO:0007067 denotes mitosis
T2419 3555-3559 CL_GO_EXT:cell denotes cell
T2420 3555-3565 GO:0007049 denotes cell-cycle
T2421 3632-3639 GO:0007067 denotes mitotic
T2422 3658-3662 PR_EXT:000004503 denotes Atrx
T2423 3662-3666 SO_EXT:sequence_nullness denotes null
T2424 3667-3669 CL:0002322 denotes ES
T2425 3670-3676 SO_EXT:sequence_cloned_entity denotes clones
T2426 3697-3703 GO_EXT:biological_growth_entity_or_process denotes growth
T2427 3742-3748 GO_EXT:biological_growth_entity_or_process denotes growth
T2428 3763-3767 PR_EXT:000004503 denotes Atrx
T2429 3767-3771 SO_EXT:sequence_nullness denotes null
T2430 3772-3780 CL:0002322 denotes ES cells
T2431 3775-3780 CL_GO_EXT:cell denotes cells
T2432 3795-3821 GO:0043065 denotes up-regulation of apoptosis
T2433 3834-3839 CL_GO_EXT:cell denotes cells
T2434 3845-3854 PR_EXT:000004078 denotes Annexin V
T2435 3900-3909 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T2436 3900-3915 CL:0000445 denotes apoptotic cells
T2437 3910-3915 CL_GO_EXT:cell denotes cells
T2438 3977-3981 PR_EXT:000004503 denotes Atrx
T2439 3993-3999 GO_EXT:biological_growth_entity_or_process denotes growth
T2440 4019-4027 CL:0002322 denotes ES cells
T2441 4022-4027 CL_GO_EXT:cell denotes cells
T2442 4036-4040 PR_EXT:000004503 denotes Atrx
T2443 4066-4070 CL_GO_EXT:cell denotes cell
T2444 4066-4076 GO:0007049 denotes cell cycle
T2445 4111-4115 CL_GO_EXT:cell denotes cell
T2446 4111-4121 GO:0008219 denotes cell death
T2447 4146-4159 GO_PATO_EXT:cell_proliferation_or_proliferativity denotes proliferative
T2448 4190-4194 PR_EXT:000004503 denotes Atrx
T2449 4194-4198 SO_EXT:sequence_nullness denotes null
T2450 4199-4207 CL:0002322 denotes ES cells
T2451 4202-4207 CL_GO_EXT:cell denotes cells
T2452 4254-4269 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T2453 4324-4330 GO_EXT:biological_growth_entity_or_process denotes growth
T2454 4395-4409 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T2455 4410-4418 CL:0002322 denotes ES cells
T2456 4413-4418 CL_GO_EXT:cell denotes cells
T2457 4445-4459 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T2458 4460-4464 CL_GO_EXT:cell denotes cell
T2459 4529-4538 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2460 4546-4551 NCBITaxon:9606 denotes human
T2461 4552-4556 PR_EXT:000004503 denotes ATRX
T2462 4557-4561 SO_EXT:0000704 denotes gene
T2463 4608-4611 CHEBI_SO_EXT:DNA denotes DNA
T2464 4608-4623 GO:0006306 denotes DNA methylation
T2465 4612-4623 GO_MOP_EXT:methylation denotes methylation
T2466 4635-4645 SO_EXT:sequence_repeat_unit_or_region denotes repetitive
T2467 4646-4655 SO_EXT:biological_sequence denotes sequences
T2468 4667-4672 NCBITaxon:9606 denotes human
T2469 4673-4679 SO_EXT:0001026 denotes genome
T2470 4699-4710 GO_EXT:transcription denotes transcribed
T2471 4725-4734 GO:0005840 denotes ribosomal
T2472 4735-4738 CHEBI_SO_EXT:DNA denotes DNA
T2473 4746-4752 SO_EXT:sequence_repeat_unit_or_region denotes repeat
T2474 4787-4797 GO_MOP_EXT:methylation denotes methylated
T2475 4805-4806 GO:0000805 denotes X
T2476 4835-4846 NCBITaxon:1 denotes individuals
T2477 4854-4865 GO_MOP_EXT:methylation denotes methylation
T2478 4876-4895 GO_EXT:0015666 denotes restriction enzymes
T2479 4888-4895 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T2480 4930-4941 GO_MOP_EXT:methylation denotes methylation
T2481 4977-4982 NCBITaxon:10088 denotes mouse
T2482 4988-4995 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T2483 4999-5003 PR_EXT:000004503 denotes Atrx
T2484 5003-5007 SO_EXT:sequence_nullness denotes null
T2485 5008-5016 CL:0002322 denotes ES cells
T2486 5011-5016 CL_GO_EXT:cell denotes cells
T2487 5026-5041 UBERON:0014374 denotes embryoid bodies
T2488 5054-5062 CL:0002322 denotes ES cells
T2489 5057-5062 CL_GO_EXT:cell denotes cells
T2490 5067-5082 UBERON:0014374 denotes embryoid bodies
T2491 5104-5108 PR_EXT:000004503 denotes Atrx
T2492 5109-5115 SO_EXT:0001023 denotes allele
T2493 5117-5121 PR_EXT:000004503 denotes Atrx
T2494 5122-5124 SO_EXT:wild_type_entity_or_quality denotes WT
T2495 5128-5132 PR_EXT:000004503 denotes Atrx
T2496 5133-5137 SO:0000359 denotes flox
T2497 5192-5202 GO_MOP_EXT:methylation denotes methylated
T2498 5221-5225 PR_EXT:000004503 denotes Atrx
T2499 5235-5243 CL:0002322 denotes ES cells
T2500 5238-5243 CL_GO_EXT:cell denotes cells
T2501 5285-5296 GO_MOP_EXT:methylation denotes methylation
T2502 5304-5309 NCBITaxon:9606 denotes human
T2503 5315-5322 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T2504 5378-5379 GO:0000805 denotes X
T2505 5396-5401 NCBITaxon:10088 denotes mouse
T2506 5402-5412 SO_EXT:sequence_repeat_unit_or_region denotes repetitive
T2507 5413-5421 SO_EXT:biological_sequence denotes sequence
T2508 5443-5450 CL:0002322 denotes ES cell
T2509 5446-5450 CL_GO_EXT:cell denotes cell
T2510 5451-5454 CHEBI_SO_EXT:DNA denotes DNA
T2511 5467-5482 GO:0000792 denotes heterochromatic
T2512 5489-5498 SO_EXT:satellite_unit_or_region denotes satellite
T2513 5530-5539 _FRAGMENT denotes satellite
T2514 5561-5568 SO_EXT:satellite_unit_or_region denotes repeats
T2515 5594-5604 NCBITaxon:11632 denotes retroviral
T2516 5605-5612 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T2517 5725-5732 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T2518 5804-5813 SO_EXT:satellite_unit_or_region denotes satellite
T2519 5821-5830 SO_EXT:satellite_unit_or_region denotes satellite
T2520 5832-5842 GO_MOP_EXT:methylation denotes methylated
T2521 5846-5855 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2522 5856-5864 CL:0002322 denotes ES cells
T2523 5859-5864 CL_GO_EXT:cell denotes cells
T2524 5875-5886 GO_MOP_EXT:methylation denotes methylation
T2525 5934-5938 PR_EXT:000004503 denotes Atrx
T2526 6047-6051 PR_EXT:000004503 denotes ATRX
T2527 6052-6059 CHEBI_PR_EXT:protein denotes protein
T2528 6064-6067 CHEBI_SO_EXT:DNA denotes DNA
T2529 6064-6079 GO:0006306 denotes DNA methylation
T2530 6068-6079 GO_MOP_EXT:methylation denotes methylation
T2531 6092-6097 NCBITaxon:9606 denotes human
T2532 6126-6131 NCBITaxon:10088 denotes mouse
T2533 6132-6137 CL_GO_EXT:cell denotes cells
R1312 T2514 T2513 _lexicallyChainedTo repeats,satellite

2_test

Id Subject Object Predicate Lexical cue
16628246-206429-85799748 3523-3525 206429 denotes 13
16628246-10742099-85799749 4681-4683 10742099 denotes 11
T34229 3523-3525 206429 denotes 13
T31994 4681-4683 10742099 denotes 11

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2213 44-48 PR:000004503 denotes Atrx
T2214 53-61 CL:0002322 denotes ES Cells
T2215 62-66 PR:000004503 denotes Atrx
T2216 71-79 CL:0002322 denotes ES cells
T2217 137-144 GO:0040007 denotes growing
T2218 150-154 PR:000004503 denotes Atrx
T2219 156-158 CL:0002322 denotes ES
T2220 275-279 PR:000004503 denotes Atrx
T2221 283-290 CL:0002322 denotes ES cell
T2222 311-315 PR:000004503 denotes Atrx
T2223 321-325 PR:000004503 denotes Atrx
T2224 330-337 CL:0002322 denotes ES cell
T2225 387-391 PR:000004503 denotes Atrx
T2226 412-416 PR:000004503 denotes Atrx
T2227 426-430 PR:000004503 denotes Atrx
T2228 431-435 SO:0000359 denotes flox
T2229 436-442 SO:0001023 denotes allele
T2230 448-452 PR:000004503 denotes Atrx
T2231 469-473 PR:000004503 denotes Atrx
T2232 482-488 SO:0001023 denotes allele
T2233 490-498 CL:0002322 denotes ES cells
T2234 640-647 SO:0001023 denotes alleles
T2235 754-758 PR:000004503 denotes Atrx
T2236 767-773 SO:0001023 denotes allele
T2237 803-807 PR:000004503 denotes Atrx
T2238 811-819 CL:0002322 denotes ES cells
T2239 842-846 PR:000004503 denotes Atrx
T2240 847-851 SO:0000359 denotes flox
T2241 852-858 SO:0001023 denotes allele
T2242 940-944 PR:000004503 denotes Atrx
T2243 945-952 SO:0001023 denotes alleles
T2244 954-958 PR:000004503 denotes Atrx
T2245 966-970 PR:000004503 denotes Atrx
T2246 971-975 SO:0000359 denotes flox
T2247 1069-1073 PR:000004503 denotes Atrx
T2248 1078-1086 CL:0002322 denotes ES cells
T2249 1231-1235 PR:000004503 denotes Atrx
T2250 1271-1278 CL:0002322 denotes ES cell
T2251 2995-3005 GO:0007049 denotes cell-cycle
T2252 3031-3035 PR:000004503 denotes Atrx
T2253 3053-3063 GO:0007049 denotes cell cycle
T2254 3080-3097 CHEBI:472552 denotes bromodeoxyuridine
T2255 3099-3103 CHEBI:472552 denotes BrdU
T2256 3112-3120 CL:0002322 denotes ES cells
T2257 3172-3176 PR:000004503 denotes Atrx
T2258 3181-3188 CL:0002322 denotes ES cell
T2259 3208-3218 GO:0007049 denotes cell cycle
T2260 3259-3267 CL:0002322 denotes ES cells
T2261 3289-3293 PR:000004503 denotes Atrx
T2262 3294-3300 SO:0001023 denotes allele
T2263 3302-3306 PR:000004503 denotes Atrx
T2264 3313-3317 PR:000004503 denotes Atrx
T2265 3318-3322 SO:0000359 denotes flox
T2266 3362-3369 GO:0007067 denotes mitotic
T2267 3432-3440 CL:0002322 denotes ES cells
T2268 3468-3475 CHEBI:15358 denotes histone
T2269 3468-3478 PR:000027594 denotes histone H3
T2270 3501-3508 GO:0007067 denotes mitosis
T2271 3555-3565 GO:0007049 denotes cell-cycle
T2272 3632-3639 GO:0007067 denotes mitotic
T2273 3658-3662 PR:000004503 denotes Atrx
T2274 3667-3669 CL:0002322 denotes ES
T2275 3763-3767 PR:000004503 denotes Atrx
T2276 3772-3780 CL:0002322 denotes ES cells
T2277 3795-3821 GO:0043065 denotes up-regulation of apoptosis
T2278 3845-3854 PR:000004078 denotes Annexin V
T2279 3900-3915 CL:0000445 denotes apoptotic cells
T2280 3977-3981 PR:000004503 denotes Atrx
T2281 4019-4027 CL:0002322 denotes ES cells
T2282 4036-4040 PR:000004503 denotes Atrx
T2283 4066-4076 GO:0007049 denotes cell cycle
T2284 4111-4121 GO:0008219 denotes cell death
T2285 4190-4194 PR:000004503 denotes Atrx
T2286 4199-4207 CL:0002322 denotes ES cells
T2287 4410-4418 CL:0002322 denotes ES cells
T2288 4546-4551 NCBITaxon:9606 denotes human
T2289 4552-4556 PR:000004503 denotes ATRX
T2290 4557-4561 SO:0000704 denotes gene
T2291 4608-4623 GO:0006306 denotes DNA methylation
T2292 4667-4672 NCBITaxon:9606 denotes human
T2293 4673-4679 SO:0001026 denotes genome
T2294 4725-4734 GO:0005840 denotes ribosomal
T2295 4805-4806 GO:0000805 denotes X
T2296 4835-4846 NCBITaxon:1 denotes individuals
T2297 4977-4982 NCBITaxon:10088 denotes mouse
T2298 4999-5003 PR:000004503 denotes Atrx
T2299 5008-5016 CL:0002322 denotes ES cells
T2300 5026-5041 UBERON:0014374 denotes embryoid bodies
T2301 5054-5062 CL:0002322 denotes ES cells
T2302 5067-5082 UBERON:0014374 denotes embryoid bodies
T2303 5104-5108 PR:000004503 denotes Atrx
T2304 5109-5115 SO:0001023 denotes allele
T2305 5117-5121 PR:000004503 denotes Atrx
T2306 5128-5132 PR:000004503 denotes Atrx
T2307 5133-5137 SO:0000359 denotes flox
T2308 5221-5225 PR:000004503 denotes Atrx
T2309 5235-5243 CL:0002322 denotes ES cells
T2310 5304-5309 NCBITaxon:9606 denotes human
T2311 5378-5379 GO:0000805 denotes X
T2312 5396-5401 NCBITaxon:10088 denotes mouse
T2313 5443-5450 CL:0002322 denotes ES cell
T2314 5467-5482 GO:0000792 denotes heterochromatic
T2315 5594-5604 NCBITaxon:11632 denotes retroviral
T2316 5856-5864 CL:0002322 denotes ES cells
T2317 5934-5938 PR:000004503 denotes Atrx
T2318 6047-6051 PR:000004503 denotes ATRX
T2319 6064-6079 GO:0006306 denotes DNA methylation
T2320 6092-6097 NCBITaxon:9606 denotes human
T2321 6126-6131 NCBITaxon:10088 denotes mouse