Id |
Subject |
Object |
Predicate |
Lexical cue |
T27909 |
0-10 |
NN |
denotes |
Luciferase |
T27910 |
11-16 |
NN |
denotes |
assay |
T27911 |
16-241 |
sentence |
denotes |
For transcriptional analysis of the 1.2-kb promoter region of mr-s, we constructed a reporter plasmid (pro1.2k) by subcloning a 1.2-kb upstream genomic fragment of mr-s gene into a pGL3 luciferase reporter plasmid (Promega). |
T27912 |
17-20 |
IN |
denotes |
For |
T27913 |
88-99 |
VBD |
denotes |
constructed |
T27914 |
21-36 |
JJ |
denotes |
transcriptional |
T27915 |
37-45 |
NN |
denotes |
analysis |
T27916 |
46-48 |
IN |
denotes |
of |
T27917 |
49-52 |
DT |
denotes |
the |
T27918 |
69-75 |
NN |
denotes |
region |
T27919 |
53-56 |
CD |
denotes |
1.2 |
T27920 |
57-59 |
NN |
denotes |
kb |
T27921 |
56-57 |
HYPH |
denotes |
- |
T27922 |
60-68 |
NN |
denotes |
promoter |
T27923 |
76-78 |
IN |
denotes |
of |
T27924 |
79-81 |
NN |
denotes |
mr |
T27925 |
82-83 |
NN |
denotes |
s |
T27926 |
81-82 |
HYPH |
denotes |
- |
T27927 |
83-85 |
, |
denotes |
, |
T27928 |
85-87 |
PRP |
denotes |
we |
T27929 |
100-101 |
DT |
denotes |
a |
T27930 |
111-118 |
NN |
denotes |
plasmid |
T27931 |
102-110 |
NN |
denotes |
reporter |
T27932 |
119-120 |
-LRB- |
denotes |
( |
T27933 |
120-127 |
NN |
denotes |
pro1.2k |
T27934 |
127-128 |
-RRB- |
denotes |
) |
T27935 |
129-131 |
IN |
denotes |
by |
T27936 |
132-142 |
VBG |
denotes |
subcloning |
T27937 |
143-144 |
DT |
denotes |
a |
T27938 |
169-177 |
NN |
denotes |
fragment |
T27939 |
145-148 |
CD |
denotes |
1.2 |
T27940 |
149-151 |
NN |
denotes |
kb |
T27941 |
148-149 |
HYPH |
denotes |
- |
T27942 |
152-160 |
JJ |
denotes |
upstream |
T27943 |
161-168 |
JJ |
denotes |
genomic |
T27944 |
178-180 |
IN |
denotes |
of |
T27945 |
181-183 |
NN |
denotes |
mr |
T27946 |
184-185 |
NN |
denotes |
s |
T27947 |
183-184 |
HYPH |
denotes |
- |
T27948 |
186-190 |
NN |
denotes |
gene |
T27949 |
191-195 |
IN |
denotes |
into |
T27950 |
196-197 |
DT |
denotes |
a |
T27951 |
223-230 |
NN |
denotes |
plasmid |
T27952 |
198-202 |
NN |
denotes |
pGL3 |
T27953 |
214-222 |
NN |
denotes |
reporter |
T27954 |
203-213 |
NN |
denotes |
luciferase |
T27955 |
231-232 |
-LRB- |
denotes |
( |
T27956 |
232-239 |
NNP |
denotes |
Promega |
T27957 |
239-240 |
-RRB- |
denotes |
) |
T27958 |
240-241 |
. |
denotes |
. |
T27959 |
241-403 |
sentence |
denotes |
The expression vectors were constructed by subcloning full-length Crx, Otx2, Nrl genes into a pMIK expression vector (a gift from Dr. K. Maruyama), respectively. |
T27960 |
242-245 |
DT |
denotes |
The |
T27961 |
257-264 |
NNS |
denotes |
vectors |
T27962 |
246-256 |
NN |
denotes |
expression |
T27963 |
270-281 |
VBN |
denotes |
constructed |
T27964 |
265-269 |
VBD |
denotes |
were |
T27965 |
282-284 |
IN |
denotes |
by |
T27966 |
285-295 |
VBG |
denotes |
subcloning |
T27967 |
296-300 |
JJ |
denotes |
full |
T27968 |
301-307 |
NN |
denotes |
length |
T27969 |
300-301 |
HYPH |
denotes |
- |
T27970 |
323-328 |
NNS |
denotes |
genes |
T27971 |
308-311 |
NN |
denotes |
Crx |
T27972 |
319-322 |
NN |
denotes |
Nrl |
T27973 |
311-313 |
, |
denotes |
, |
T27974 |
313-317 |
NN |
denotes |
Otx2 |
T27975 |
317-319 |
, |
denotes |
, |
T27976 |
329-333 |
IN |
denotes |
into |
T27977 |
334-335 |
DT |
denotes |
a |
T27978 |
352-358 |
NN |
denotes |
vector |
T27979 |
336-340 |
NN |
denotes |
pMIK |
T27980 |
341-351 |
NN |
denotes |
expression |
T27981 |
359-360 |
-LRB- |
denotes |
( |
T27982 |
362-366 |
NN |
denotes |
gift |
T27983 |
360-361 |
DT |
denotes |
a |
T27984 |
367-371 |
IN |
denotes |
from |
T27985 |
372-375 |
NNP |
denotes |
Dr. |
T27986 |
379-387 |
NNP |
denotes |
Maruyama |
T27987 |
376-378 |
NNP |
denotes |
K. |
T27988 |
387-388 |
-RRB- |
denotes |
) |
T27989 |
388-390 |
, |
denotes |
, |
T27990 |
390-402 |
RB |
denotes |
respectively |
T27991 |
402-403 |
. |
denotes |
. |
T27992 |
403-520 |
sentence |
denotes |
For the "mut1259" vector, the Crx binding site at the -1259 bp position was mutated by replacing GGATTA with AGATCT. |
T27993 |
404-407 |
IN |
denotes |
For |
T27994 |
480-487 |
VBN |
denotes |
mutated |
T27995 |
408-411 |
DT |
denotes |
the |
T27996 |
422-428 |
NN |
denotes |
vector |
T27997 |
412-413 |
`` |
denotes |
" |
T27998 |
413-420 |
NN |
denotes |
mut1259 |
T27999 |
420-421 |
'' |
denotes |
" |
T28000 |
428-430 |
, |
denotes |
, |
T28001 |
430-433 |
DT |
denotes |
the |
T28002 |
446-450 |
NN |
denotes |
site |
T28003 |
434-437 |
NN |
denotes |
Crx |
T28004 |
438-445 |
NN |
denotes |
binding |
T28005 |
451-453 |
IN |
denotes |
at |
T28006 |
454-457 |
DT |
denotes |
the |
T28007 |
467-475 |
NN |
denotes |
position |
T28008 |
458-459 |
SYM |
denotes |
- |
T28009 |
459-463 |
CD |
denotes |
1259 |
T28010 |
464-466 |
NN |
denotes |
bp |
T28011 |
476-479 |
VBD |
denotes |
was |
T28012 |
488-490 |
IN |
denotes |
by |
T28013 |
491-500 |
VBG |
denotes |
replacing |
T28014 |
501-507 |
NN |
denotes |
GGATTA |
T28015 |
508-512 |
IN |
denotes |
with |
T28016 |
513-519 |
NN |
denotes |
AGATCT |
T28017 |
519-520 |
. |
denotes |
. |
T28018 |
520-635 |
sentence |
denotes |
For the "mut198" vector, the Crx binding site at the -198 bp position was mutated by replacing TAATCC with GAATTC. |
T28019 |
521-524 |
IN |
denotes |
For |
T28020 |
595-602 |
VBN |
denotes |
mutated |
T28021 |
525-528 |
DT |
denotes |
the |
T28022 |
538-544 |
NN |
denotes |
vector |
T28023 |
529-530 |
`` |
denotes |
" |
T28024 |
530-536 |
NN |
denotes |
mut198 |
T28025 |
536-537 |
'' |
denotes |
" |
T28026 |
544-546 |
, |
denotes |
, |
T28027 |
546-549 |
DT |
denotes |
the |
T28028 |
562-566 |
NN |
denotes |
site |
T28029 |
550-553 |
NN |
denotes |
Crx |
T28030 |
554-561 |
NN |
denotes |
binding |
T28031 |
567-569 |
IN |
denotes |
at |
T28032 |
570-573 |
DT |
denotes |
the |
T28033 |
582-590 |
NN |
denotes |
position |
T28034 |
574-575 |
SYM |
denotes |
- |
T28035 |
575-578 |
CD |
denotes |
198 |
T28036 |
579-581 |
NN |
denotes |
bp |
T28037 |
591-594 |
VBD |
denotes |
was |
T28038 |
603-605 |
IN |
denotes |
by |
T28039 |
606-615 |
VBG |
denotes |
replacing |
T28040 |
616-622 |
NN |
denotes |
TAATCC |
T28041 |
623-627 |
IN |
denotes |
with |
T28042 |
628-634 |
NN |
denotes |
GAATTC |
T28043 |
634-635 |
. |
denotes |
. |
T28044 |
635-748 |
sentence |
denotes |
For the "mut72" vector, the Crx binding site at the -72 bp position was mutated by replacing GGATTA with GAATTC. |
T28045 |
636-639 |
IN |
denotes |
For |
T28046 |
708-715 |
VBN |
denotes |
mutated |
T28047 |
640-643 |
DT |
denotes |
the |
T28048 |
652-658 |
NN |
denotes |
vector |
T28049 |
644-645 |
`` |
denotes |
" |
T28050 |
645-650 |
NN |
denotes |
mut72 |
T28051 |
650-651 |
'' |
denotes |
" |
T28052 |
658-660 |
, |
denotes |
, |
T28053 |
660-663 |
DT |
denotes |
the |
T28054 |
676-680 |
NN |
denotes |
site |
T28055 |
664-667 |
NN |
denotes |
Crx |
T28056 |
668-675 |
NN |
denotes |
binding |
T28057 |
681-683 |
IN |
denotes |
at |
T28058 |
684-687 |
DT |
denotes |
the |
T28059 |
695-703 |
NN |
denotes |
position |
T28060 |
688-689 |
SYM |
denotes |
- |
T28061 |
689-691 |
CD |
denotes |
72 |
T28062 |
692-694 |
NN |
denotes |
bp |
T28063 |
704-707 |
VBD |
denotes |
was |
T28064 |
716-718 |
IN |
denotes |
by |
T28065 |
719-728 |
VBG |
denotes |
replacing |
T28066 |
729-735 |
NN |
denotes |
GGATTA |
T28067 |
736-740 |
IN |
denotes |
with |
T28068 |
741-747 |
NN |
denotes |
GAATTC |
T28069 |
747-748 |
. |
denotes |
. |
T28070 |
748-819 |
sentence |
denotes |
For the "mut all" vector, all of three Crx binding sites were mutated. |
T28071 |
749-752 |
IN |
denotes |
For |
T28072 |
811-818 |
VBN |
denotes |
mutated |
T28073 |
753-756 |
DT |
denotes |
the |
T28074 |
767-773 |
NN |
denotes |
vector |
T28075 |
757-758 |
`` |
denotes |
" |
T28076 |
758-761 |
NN |
denotes |
mut |
T28077 |
762-765 |
NN |
denotes |
all |
T28078 |
765-766 |
'' |
denotes |
" |
T28079 |
773-775 |
, |
denotes |
, |
T28080 |
775-778 |
DT |
denotes |
all |
T28081 |
779-781 |
IN |
denotes |
of |
T28082 |
782-787 |
CD |
denotes |
three |
T28083 |
800-805 |
NNS |
denotes |
sites |
T28084 |
788-791 |
NN |
denotes |
Crx |
T28085 |
792-799 |
NN |
denotes |
binding |
T28086 |
806-810 |
VBD |
denotes |
were |
T28087 |
818-819 |
. |
denotes |
. |
T28088 |
819-1085 |
sentence |
denotes |
5xGAL4-pGL3 Control reporter plasmid, which contains five copies of the GAL4 DNA recognition sequence positioned immediately upstream of SV40 minimal promoter, was kindly gifted from Dr. T. Noguchi and used for analysis of the transcriptional activity of mr-s [50]. |
T28089 |
820-826 |
NN |
denotes |
5xGAL4 |
T28090 |
827-831 |
NN |
denotes |
pGL3 |
T28091 |
826-827 |
HYPH |
denotes |
- |
T28092 |
849-856 |
NN |
denotes |
plasmid |
T28093 |
832-839 |
NN |
denotes |
Control |
T28094 |
840-848 |
NN |
denotes |
reporter |
T28095 |
991-997 |
VBN |
denotes |
gifted |
T28096 |
856-858 |
, |
denotes |
, |
T28097 |
858-863 |
WDT |
denotes |
which |
T28098 |
864-872 |
VBZ |
denotes |
contains |
T28099 |
873-877 |
CD |
denotes |
five |
T28100 |
878-884 |
NNS |
denotes |
copies |
T28101 |
885-887 |
IN |
denotes |
of |
T28102 |
888-891 |
DT |
denotes |
the |
T28103 |
913-921 |
NN |
denotes |
sequence |
T28104 |
892-896 |
NN |
denotes |
GAL4 |
T28105 |
897-900 |
NN |
denotes |
DNA |
T28106 |
901-912 |
NN |
denotes |
recognition |
T28107 |
922-932 |
VBN |
denotes |
positioned |
T28108 |
933-944 |
RB |
denotes |
immediately |
T28109 |
945-953 |
IN |
denotes |
upstream |
T28110 |
954-956 |
IN |
denotes |
of |
T28111 |
957-961 |
NN |
denotes |
SV40 |
T28112 |
970-978 |
NN |
denotes |
promoter |
T28113 |
962-969 |
JJ |
denotes |
minimal |
T28114 |
978-980 |
, |
denotes |
, |
T28115 |
980-983 |
VBD |
denotes |
was |
T28116 |
984-990 |
RB |
denotes |
kindly |
T28117 |
998-1002 |
IN |
denotes |
from |
T28118 |
1003-1006 |
NNP |
denotes |
Dr. |
T28119 |
1010-1017 |
NNP |
denotes |
Noguchi |
T28120 |
1007-1009 |
NNP |
denotes |
T. |
T28121 |
1018-1021 |
CC |
denotes |
and |
T28122 |
1022-1026 |
VBN |
denotes |
used |
T28123 |
1027-1030 |
IN |
denotes |
for |
T28124 |
1031-1039 |
NN |
denotes |
analysis |
T28125 |
1040-1042 |
IN |
denotes |
of |
T28126 |
1043-1046 |
DT |
denotes |
the |
T28127 |
1063-1071 |
NN |
denotes |
activity |
T28128 |
1047-1062 |
JJ |
denotes |
transcriptional |
T28129 |
1072-1074 |
IN |
denotes |
of |
T28130 |
1075-1077 |
NN |
denotes |
mr |
T28131 |
1078-1079 |
NN |
denotes |
s |
T28132 |
1077-1078 |
HYPH |
denotes |
- |
T28133 |
1080-1081 |
-LRB- |
denotes |
[ |
T28134 |
1081-1083 |
CD |
denotes |
50 |
T28135 |
1083-1084 |
-RRB- |
denotes |
] |
T28136 |
1084-1085 |
. |
denotes |
. |
T28137 |
1085-1221 |
sentence |
denotes |
To generate effector plasmids, various deletion fragments were produced by PCR reaction and subcloned into pGBKT7 vector, respectively. |
T28138 |
1086-1088 |
TO |
denotes |
To |
T28139 |
1089-1097 |
VB |
denotes |
generate |
T28140 |
1149-1157 |
VBN |
denotes |
produced |
T28141 |
1098-1106 |
NN |
denotes |
effector |
T28142 |
1107-1115 |
NNS |
denotes |
plasmids |
T28143 |
1115-1117 |
, |
denotes |
, |
T28144 |
1117-1124 |
JJ |
denotes |
various |
T28145 |
1134-1143 |
NNS |
denotes |
fragments |
T28146 |
1125-1133 |
NN |
denotes |
deletion |
T28147 |
1144-1148 |
VBD |
denotes |
were |
T28148 |
1158-1160 |
IN |
denotes |
by |
T28149 |
1161-1164 |
NN |
denotes |
PCR |
T28150 |
1165-1173 |
NN |
denotes |
reaction |
T28151 |
1174-1177 |
CC |
denotes |
and |
T28152 |
1178-1187 |
VBN |
denotes |
subcloned |
T28153 |
1188-1192 |
IN |
denotes |
into |
T28154 |
1193-1199 |
NN |
denotes |
pGBKT7 |
T28155 |
1200-1206 |
NN |
denotes |
vector |
T28156 |
1206-1208 |
, |
denotes |
, |
T28157 |
1208-1220 |
RB |
denotes |
respectively |
T28158 |
1220-1221 |
. |
denotes |
. |
T28159 |
1221-1335 |
sentence |
denotes |
These fragments were digested with the sequence, which encodes GAL4 DNA binding domain, and inserted into pcDNA3. |
T28160 |
1222-1227 |
DT |
denotes |
These |
T28161 |
1228-1237 |
NNS |
denotes |
fragments |
T28162 |
1243-1251 |
VBN |
denotes |
digested |
T28163 |
1238-1242 |
VBD |
denotes |
were |
T28164 |
1252-1256 |
IN |
denotes |
with |
T28165 |
1257-1260 |
DT |
denotes |
the |
T28166 |
1261-1269 |
NN |
denotes |
sequence |
T28167 |
1269-1271 |
, |
denotes |
, |
T28168 |
1271-1276 |
WDT |
denotes |
which |
T28169 |
1277-1284 |
VBZ |
denotes |
encodes |
T28170 |
1285-1289 |
NN |
denotes |
GAL4 |
T28171 |
1302-1308 |
NN |
denotes |
domain |
T28172 |
1290-1293 |
NN |
denotes |
DNA |
T28173 |
1294-1301 |
NN |
denotes |
binding |
T28174 |
1308-1310 |
, |
denotes |
, |
T28175 |
1310-1313 |
CC |
denotes |
and |
T28176 |
1314-1322 |
VBN |
denotes |
inserted |
T28177 |
1323-1327 |
IN |
denotes |
into |
T28178 |
1328-1334 |
NN |
denotes |
pcDNA3 |
T28179 |
1334-1335 |
. |
denotes |
. |
T28180 |
1335-1488 |
sentence |
denotes |
We transfected 0.1 μg of reporter plasmid DNA and 2 μg of the expression vector DNA per 6 cm dish into HEK293T cells using Fugene6 transfection reagent. |
T28181 |
1336-1338 |
PRP |
denotes |
We |
T28182 |
1339-1350 |
VBD |
denotes |
transfected |
T28183 |
1351-1354 |
CD |
denotes |
0.1 |
T28184 |
1355-1357 |
NN |
denotes |
μg |
T28185 |
1358-1360 |
IN |
denotes |
of |
T28186 |
1361-1369 |
NN |
denotes |
reporter |
T28187 |
1378-1381 |
NN |
denotes |
DNA |
T28188 |
1370-1377 |
NN |
denotes |
plasmid |
T28189 |
1382-1385 |
CC |
denotes |
and |
T28190 |
1386-1387 |
CD |
denotes |
2 |
T28191 |
1388-1390 |
NN |
denotes |
μg |
T28192 |
1391-1393 |
IN |
denotes |
of |
T28193 |
1394-1397 |
DT |
denotes |
the |
T28194 |
1416-1419 |
NN |
denotes |
DNA |
T28195 |
1398-1408 |
NN |
denotes |
expression |
T28196 |
1409-1415 |
NN |
denotes |
vector |
T28197 |
1420-1423 |
IN |
denotes |
per |
T28198 |
1424-1425 |
CD |
denotes |
6 |
T28199 |
1426-1428 |
NN |
denotes |
cm |
T28200 |
1429-1433 |
NN |
denotes |
dish |
T28201 |
1434-1438 |
IN |
denotes |
into |
T28202 |
1439-1446 |
NN |
denotes |
HEK293T |
T28203 |
1447-1452 |
NNS |
denotes |
cells |
T28204 |
1453-1458 |
VBG |
denotes |
using |
T28205 |
1459-1466 |
NN |
denotes |
Fugene6 |
T28206 |
1480-1487 |
NN |
denotes |
reagent |
T28207 |
1467-1479 |
NN |
denotes |
transfection |
T28208 |
1487-1488 |
. |
denotes |
. |
T28209 |
1488-1546 |
sentence |
denotes |
We analyzed luciferase activity 48 hr after transfection. |
T28210 |
1489-1491 |
PRP |
denotes |
We |
T28211 |
1492-1500 |
VBD |
denotes |
analyzed |
T28212 |
1501-1511 |
NN |
denotes |
luciferase |
T28213 |
1512-1520 |
NN |
denotes |
activity |
T28214 |
1521-1523 |
CD |
denotes |
48 |
T28215 |
1524-1526 |
NN |
denotes |
hr |
T28216 |
1527-1532 |
IN |
denotes |
after |
T28217 |
1533-1545 |
NN |
denotes |
transfection |
T28218 |
1545-1546 |
. |
denotes |
. |
R7870 |
T27909 |
T27910 |
compound |
Luciferase,assay |
R7871 |
T27912 |
T27913 |
prep |
For,constructed |
R7872 |
T27914 |
T27915 |
amod |
transcriptional,analysis |
R7873 |
T27915 |
T27912 |
pobj |
analysis,For |
R7874 |
T27916 |
T27915 |
prep |
of,analysis |
R7875 |
T27917 |
T27918 |
det |
the,region |
R7876 |
T27918 |
T27916 |
pobj |
region,of |
R7877 |
T27919 |
T27920 |
nummod |
1.2,kb |
R7878 |
T27920 |
T27918 |
compound |
kb,region |
R7879 |
T27921 |
T27920 |
punct |
-,kb |
R7880 |
T27922 |
T27918 |
compound |
promoter,region |
R7881 |
T27923 |
T27918 |
prep |
of,region |
R7882 |
T27924 |
T27925 |
compound |
mr,s |
R7883 |
T27925 |
T27923 |
pobj |
s,of |
R7884 |
T27926 |
T27925 |
punct |
-,s |
R7885 |
T27927 |
T27913 |
punct |
", ",constructed |
R7886 |
T27928 |
T27913 |
nsubj |
we,constructed |
R7887 |
T27929 |
T27930 |
det |
a,plasmid |
R7888 |
T27930 |
T27913 |
dobj |
plasmid,constructed |
R7889 |
T27931 |
T27930 |
compound |
reporter,plasmid |
R7890 |
T27932 |
T27933 |
punct |
(,pro1.2k |
R7891 |
T27933 |
T27930 |
parataxis |
pro1.2k,plasmid |
R7892 |
T27934 |
T27933 |
punct |
),pro1.2k |
R7893 |
T27935 |
T27913 |
prep |
by,constructed |
R7894 |
T27936 |
T27935 |
pcomp |
subcloning,by |
R7895 |
T27937 |
T27938 |
det |
a,fragment |
R7896 |
T27938 |
T27936 |
dobj |
fragment,subcloning |
R7897 |
T27939 |
T27940 |
nummod |
1.2,kb |
R7898 |
T27940 |
T27938 |
nmod |
kb,fragment |
R7899 |
T27941 |
T27940 |
punct |
-,kb |
R7900 |
T27942 |
T27938 |
amod |
upstream,fragment |
R7901 |
T27943 |
T27938 |
amod |
genomic,fragment |
R7902 |
T27944 |
T27938 |
prep |
of,fragment |
R7903 |
T27945 |
T27946 |
compound |
mr,s |
R7904 |
T27946 |
T27948 |
compound |
s,gene |
R7905 |
T27947 |
T27946 |
punct |
-,s |
R7906 |
T27948 |
T27944 |
pobj |
gene,of |
R7907 |
T27949 |
T27936 |
prep |
into,subcloning |
R7908 |
T27950 |
T27951 |
det |
a,plasmid |
R7909 |
T27951 |
T27949 |
pobj |
plasmid,into |
R7910 |
T27952 |
T27953 |
compound |
pGL3,reporter |
R7911 |
T27953 |
T27951 |
compound |
reporter,plasmid |
R7912 |
T27954 |
T27953 |
compound |
luciferase,reporter |
R7913 |
T27955 |
T27956 |
punct |
(,Promega |
R7914 |
T27956 |
T27951 |
parataxis |
Promega,plasmid |
R7915 |
T27957 |
T27956 |
punct |
),Promega |
R7916 |
T27958 |
T27913 |
punct |
.,constructed |
R7917 |
T27960 |
T27961 |
det |
The,vectors |
R7918 |
T27961 |
T27963 |
nsubjpass |
vectors,constructed |
R7919 |
T27962 |
T27961 |
compound |
expression,vectors |
R7920 |
T27964 |
T27963 |
auxpass |
were,constructed |
R7921 |
T27965 |
T27963 |
prep |
by,constructed |
R7922 |
T27966 |
T27965 |
pcomp |
subcloning,by |
R7923 |
T27967 |
T27968 |
amod |
full,length |
R7924 |
T27968 |
T27970 |
nmod |
length,genes |
R7925 |
T27969 |
T27968 |
punct |
-,length |
R7926 |
T27970 |
T27966 |
dobj |
genes,subcloning |
R7927 |
T27971 |
T27972 |
nmod |
Crx,Nrl |
R7928 |
T27972 |
T27970 |
compound |
Nrl,genes |
R7929 |
T27973 |
T27972 |
punct |
", ",Nrl |
R7930 |
T27974 |
T27972 |
nmod |
Otx2,Nrl |
R7931 |
T27975 |
T27972 |
punct |
", ",Nrl |
R7932 |
T27976 |
T27966 |
prep |
into,subcloning |
R7933 |
T27977 |
T27978 |
det |
a,vector |
R7934 |
T27978 |
T27976 |
pobj |
vector,into |
R7935 |
T27979 |
T27978 |
compound |
pMIK,vector |
R7936 |
T27980 |
T27978 |
compound |
expression,vector |
R7937 |
T27981 |
T27982 |
punct |
(,gift |
R7938 |
T27982 |
T27978 |
parataxis |
gift,vector |
R7939 |
T27983 |
T27982 |
det |
a,gift |
R7940 |
T27984 |
T27982 |
prep |
from,gift |
R7941 |
T27985 |
T27986 |
compound |
Dr.,Maruyama |
R7942 |
T27986 |
T27984 |
pobj |
Maruyama,from |
R7943 |
T27987 |
T27986 |
compound |
K.,Maruyama |
R7944 |
T27988 |
T27982 |
punct |
),gift |
R7945 |
T27989 |
T27966 |
punct |
", ",subcloning |
R7946 |
T27990 |
T27966 |
advmod |
respectively,subcloning |
R7947 |
T27991 |
T27963 |
punct |
.,constructed |
R7948 |
T27993 |
T27994 |
prep |
For,mutated |
R7949 |
T27995 |
T27996 |
det |
the,vector |
R7950 |
T27996 |
T27993 |
pobj |
vector,For |
R7951 |
T27997 |
T27996 |
punct |
"""",vector |
R7952 |
T27998 |
T27996 |
nmod |
mut1259,vector |
R7953 |
T27999 |
T27996 |
punct |
"""",vector |
R7954 |
T28000 |
T27994 |
punct |
", ",mutated |
R7955 |
T28001 |
T28002 |
det |
the,site |
R7956 |
T28002 |
T27994 |
nsubjpass |
site,mutated |
R7957 |
T28003 |
T28004 |
compound |
Crx,binding |
R7958 |
T28004 |
T28002 |
compound |
binding,site |
R7959 |
T28005 |
T28002 |
prep |
at,site |
R7960 |
T28006 |
T28007 |
det |
the,position |
R7961 |
T28007 |
T28005 |
pobj |
position,at |
R7962 |
T28008 |
T28009 |
punct |
-,1259 |
R7963 |
T28009 |
T28010 |
nummod |
1259,bp |
R7964 |
T28010 |
T28007 |
compound |
bp,position |
R7965 |
T28011 |
T27994 |
auxpass |
was,mutated |
R7966 |
T28012 |
T27994 |
prep |
by,mutated |
R7967 |
T28013 |
T28012 |
pcomp |
replacing,by |
R7968 |
T28014 |
T28013 |
dobj |
GGATTA,replacing |
R7969 |
T28015 |
T28013 |
prep |
with,replacing |
R7970 |
T28016 |
T28015 |
pobj |
AGATCT,with |
R7971 |
T28017 |
T27994 |
punct |
.,mutated |
R7972 |
T28019 |
T28020 |
prep |
For,mutated |
R7973 |
T28021 |
T28022 |
det |
the,vector |
R7974 |
T28022 |
T28019 |
pobj |
vector,For |
R7975 |
T28023 |
T28022 |
punct |
"""",vector |
R7976 |
T28024 |
T28022 |
nmod |
mut198,vector |
R7977 |
T28025 |
T28022 |
punct |
"""",vector |
R7978 |
T28026 |
T28020 |
punct |
", ",mutated |
R7979 |
T28027 |
T28028 |
det |
the,site |
R7980 |
T28028 |
T28020 |
nsubjpass |
site,mutated |
R7981 |
T28029 |
T28030 |
compound |
Crx,binding |
R7982 |
T28030 |
T28028 |
compound |
binding,site |
R7983 |
T28031 |
T28028 |
prep |
at,site |
R7984 |
T28032 |
T28033 |
det |
the,position |
R7985 |
T28033 |
T28031 |
pobj |
position,at |
R7986 |
T28034 |
T28035 |
punct |
-,198 |
R7987 |
T28035 |
T28036 |
nummod |
198,bp |
R7988 |
T28036 |
T28033 |
compound |
bp,position |
R7989 |
T28037 |
T28020 |
auxpass |
was,mutated |
R7990 |
T28038 |
T28020 |
prep |
by,mutated |
R7991 |
T28039 |
T28038 |
pcomp |
replacing,by |
R7992 |
T28040 |
T28039 |
dobj |
TAATCC,replacing |
R7993 |
T28041 |
T28039 |
prep |
with,replacing |
R7994 |
T28042 |
T28041 |
pobj |
GAATTC,with |
R7995 |
T28043 |
T28020 |
punct |
.,mutated |
R7996 |
T28045 |
T28046 |
prep |
For,mutated |
R7997 |
T28047 |
T28048 |
det |
the,vector |
R7998 |
T28048 |
T28045 |
pobj |
vector,For |
R7999 |
T28049 |
T28048 |
punct |
"""",vector |
R8000 |
T28050 |
T28048 |
nmod |
mut72,vector |
R8001 |
T28051 |
T28048 |
punct |
"""",vector |
R8002 |
T28052 |
T28046 |
punct |
", ",mutated |
R8003 |
T28053 |
T28054 |
det |
the,site |
R8004 |
T28054 |
T28046 |
nsubjpass |
site,mutated |
R8005 |
T28055 |
T28056 |
compound |
Crx,binding |
R8006 |
T28056 |
T28054 |
compound |
binding,site |
R8007 |
T28057 |
T28054 |
prep |
at,site |
R8008 |
T28058 |
T28059 |
det |
the,position |
R8009 |
T28059 |
T28057 |
pobj |
position,at |
R8010 |
T28060 |
T28061 |
punct |
-,72 |
R8011 |
T28061 |
T28062 |
nummod |
72,bp |
R8012 |
T28062 |
T28059 |
compound |
bp,position |
R8013 |
T28063 |
T28046 |
auxpass |
was,mutated |
R8014 |
T28064 |
T28046 |
prep |
by,mutated |
R8015 |
T28065 |
T28064 |
pcomp |
replacing,by |
R8016 |
T28066 |
T28065 |
dobj |
GGATTA,replacing |
R8017 |
T28067 |
T28065 |
prep |
with,replacing |
R8018 |
T28068 |
T28067 |
pobj |
GAATTC,with |
R8019 |
T28069 |
T28046 |
punct |
.,mutated |
R8020 |
T28071 |
T28072 |
prep |
For,mutated |
R8021 |
T28073 |
T28074 |
det |
the,vector |
R8022 |
T28074 |
T28071 |
pobj |
vector,For |
R8023 |
T28075 |
T28074 |
punct |
"""",vector |
R8024 |
T28076 |
T28077 |
nmod |
mut,all |
R8025 |
T28077 |
T28074 |
nmod |
all,vector |
R8026 |
T28078 |
T28074 |
punct |
"""",vector |
R8027 |
T28079 |
T28072 |
punct |
", ",mutated |
R8028 |
T28080 |
T28072 |
nsubjpass |
all,mutated |
R8029 |
T28081 |
T28080 |
prep |
of,all |
R8030 |
T28082 |
T28083 |
nummod |
three,sites |
R8031 |
T28083 |
T28081 |
pobj |
sites,of |
R8032 |
T28084 |
T28085 |
compound |
Crx,binding |
R8033 |
T28085 |
T28083 |
compound |
binding,sites |
R8034 |
T28086 |
T28072 |
auxpass |
were,mutated |
R8035 |
T28087 |
T28072 |
punct |
.,mutated |
R8036 |
T28089 |
T28090 |
compound |
5xGAL4,pGL3 |
R8037 |
T28090 |
T28092 |
compound |
pGL3,plasmid |
R8038 |
T28091 |
T28090 |
punct |
-,pGL3 |
R8039 |
T28092 |
T28095 |
nsubjpass |
plasmid,gifted |
R8040 |
T28093 |
T28092 |
compound |
Control,plasmid |
R8041 |
T28094 |
T28092 |
compound |
reporter,plasmid |
R8042 |
T28096 |
T28092 |
punct |
", ",plasmid |
R8043 |
T28097 |
T28098 |
dep |
which,contains |
R8044 |
T28098 |
T28092 |
relcl |
contains,plasmid |
R8045 |
T28099 |
T28100 |
nummod |
five,copies |
R8046 |
T28100 |
T28098 |
dobj |
copies,contains |
R8047 |
T28101 |
T28100 |
prep |
of,copies |
R8048 |
T28102 |
T28103 |
det |
the,sequence |
R8049 |
T28103 |
T28101 |
pobj |
sequence,of |
R8050 |
T28104 |
T28103 |
compound |
GAL4,sequence |
R8051 |
T28105 |
T28106 |
compound |
DNA,recognition |
R8052 |
T28106 |
T28103 |
compound |
recognition,sequence |
R8053 |
T28107 |
T28100 |
acl |
positioned,copies |
R8054 |
T28108 |
T28107 |
advmod |
immediately,positioned |
R8055 |
T28109 |
T28108 |
advmod |
upstream,immediately |
R8056 |
T28110 |
T28108 |
prep |
of,immediately |
R8057 |
T28111 |
T28112 |
nmod |
SV40,promoter |
R8058 |
T28112 |
T28110 |
pobj |
promoter,of |
R8059 |
T28113 |
T28112 |
amod |
minimal,promoter |
R8060 |
T28114 |
T28095 |
punct |
", ",gifted |
R8061 |
T28115 |
T28095 |
auxpass |
was,gifted |
R8062 |
T28116 |
T28095 |
advmod |
kindly,gifted |
R8063 |
T28117 |
T28095 |
agent |
from,gifted |
R8064 |
T28118 |
T28119 |
compound |
Dr.,Noguchi |
R8065 |
T28119 |
T28117 |
pobj |
Noguchi,from |
R8066 |
T28120 |
T28119 |
compound |
T.,Noguchi |
R8067 |
T28121 |
T28095 |
cc |
and,gifted |
R8068 |
T28122 |
T28095 |
conj |
used,gifted |
R8069 |
T28123 |
T28122 |
prep |
for,used |
R8070 |
T28124 |
T28123 |
pobj |
analysis,for |
R8071 |
T28125 |
T28124 |
prep |
of,analysis |
R8072 |
T28126 |
T28127 |
det |
the,activity |
R8073 |
T28127 |
T28125 |
pobj |
activity,of |
R8074 |
T28128 |
T28127 |
amod |
transcriptional,activity |
R8075 |
T28129 |
T28127 |
prep |
of,activity |
R8076 |
T28130 |
T28131 |
compound |
mr,s |
R8077 |
T28131 |
T28129 |
pobj |
s,of |
R8078 |
T28132 |
T28131 |
punct |
-,s |
R8079 |
T28133 |
T28134 |
punct |
[,50 |
R8080 |
T28134 |
T28122 |
parataxis |
50,used |
R8081 |
T28135 |
T28134 |
punct |
],50 |
R8082 |
T28136 |
T28095 |
punct |
.,gifted |
R8083 |
T28138 |
T28139 |
aux |
To,generate |
R8084 |
T28139 |
T28140 |
advcl |
generate,produced |
R8085 |
T28141 |
T28142 |
compound |
effector,plasmids |
R8086 |
T28142 |
T28139 |
dobj |
plasmids,generate |
R8087 |
T28143 |
T28140 |
punct |
", ",produced |
R8088 |
T28144 |
T28145 |
amod |
various,fragments |
R8089 |
T28145 |
T28140 |
nsubj |
fragments,produced |
R8090 |
T28146 |
T28145 |
compound |
deletion,fragments |
R8091 |
T28147 |
T28140 |
aux |
were,produced |
R8092 |
T28148 |
T28140 |
prep |
by,produced |
R8093 |
T28149 |
T28150 |
compound |
PCR,reaction |
R8094 |
T28150 |
T28148 |
pobj |
reaction,by |
R8095 |
T28151 |
T28140 |
cc |
and,produced |
R8096 |
T28152 |
T28140 |
conj |
subcloned,produced |
R8097 |
T28153 |
T28152 |
prep |
into,subcloned |
R8098 |
T28154 |
T28155 |
compound |
pGBKT7,vector |
R8099 |
T28155 |
T28153 |
pobj |
vector,into |
R8100 |
T28156 |
T28140 |
punct |
", ",produced |
R8101 |
T28157 |
T28140 |
advmod |
respectively,produced |
R8102 |
T28158 |
T28140 |
punct |
.,produced |
R8103 |
T28160 |
T28161 |
det |
These,fragments |
R8104 |
T28161 |
T28162 |
nsubjpass |
fragments,digested |
R8105 |
T28163 |
T28162 |
auxpass |
were,digested |
R8106 |
T28164 |
T28162 |
prep |
with,digested |
R8107 |
T28165 |
T28166 |
det |
the,sequence |
R8108 |
T28166 |
T28164 |
pobj |
sequence,with |
R8109 |
T28167 |
T28166 |
punct |
", ",sequence |
R8110 |
T28168 |
T28169 |
dep |
which,encodes |
R8111 |
T28169 |
T28166 |
relcl |
encodes,sequence |
R8112 |
T28170 |
T28171 |
compound |
GAL4,domain |
R8113 |
T28171 |
T28169 |
dobj |
domain,encodes |
R8114 |
T28172 |
T28173 |
compound |
DNA,binding |
R8115 |
T28173 |
T28171 |
compound |
binding,domain |
R8116 |
T28174 |
T28162 |
punct |
", ",digested |
R8117 |
T28175 |
T28162 |
cc |
and,digested |
R8118 |
T28176 |
T28162 |
conj |
inserted,digested |
R8119 |
T28177 |
T28176 |
prep |
into,inserted |
R8120 |
T28178 |
T28177 |
pobj |
pcDNA3,into |
R8121 |
T28179 |
T28162 |
punct |
.,digested |
R8122 |
T28181 |
T28182 |
nsubj |
We,transfected |
R8123 |
T28183 |
T28184 |
nummod |
0.1,μg |
R8124 |
T28184 |
T28182 |
dobj |
μg,transfected |
R8125 |
T28185 |
T28184 |
prep |
of,μg |
R8126 |
T28186 |
T28187 |
compound |
reporter,DNA |
R8127 |
T28187 |
T28185 |
pobj |
DNA,of |
R8128 |
T28188 |
T28187 |
compound |
plasmid,DNA |
R8129 |
T28189 |
T28184 |
cc |
and,μg |
R8130 |
T28190 |
T28191 |
nummod |
2,μg |
R8131 |
T28191 |
T28184 |
conj |
μg,μg |
R8132 |
T28192 |
T28191 |
prep |
of,μg |
R8133 |
T28193 |
T28194 |
det |
the,DNA |
R8134 |
T28194 |
T28192 |
pobj |
DNA,of |
R8135 |
T28195 |
T28196 |
compound |
expression,vector |
R8136 |
T28196 |
T28194 |
compound |
vector,DNA |
R8137 |
T28197 |
T28184 |
prep |
per,μg |
R8138 |
T28198 |
T28199 |
nummod |
6,cm |
R8139 |
T28199 |
T28200 |
compound |
cm,dish |
R8140 |
T28200 |
T28197 |
pobj |
dish,per |
R8141 |
T28201 |
T28182 |
prep |
into,transfected |
R8142 |
T28202 |
T28203 |
compound |
HEK293T,cells |
R8143 |
T28203 |
T28201 |
pobj |
cells,into |
R8144 |
T28204 |
T28182 |
advcl |
using,transfected |
R8145 |
T28205 |
T28206 |
compound |
Fugene6,reagent |
R8146 |
T28206 |
T28204 |
dobj |
reagent,using |
R8147 |
T28207 |
T28206 |
compound |
transfection,reagent |
R8148 |
T28208 |
T28182 |
punct |
.,transfected |
R8149 |
T28210 |
T28211 |
nsubj |
We,analyzed |
R8150 |
T28212 |
T28213 |
compound |
luciferase,activity |
R8151 |
T28213 |
T28211 |
dobj |
activity,analyzed |
R8152 |
T28214 |
T28215 |
nummod |
48,hr |
R8153 |
T28215 |
T28216 |
npadvmod |
hr,after |
R8154 |
T28216 |
T28211 |
prep |
after,analyzed |
R8155 |
T28217 |
T28216 |
pobj |
transfection,after |
R8156 |
T28218 |
T28211 |
punct |
.,analyzed |