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PMC:1435744 / 4253-5179 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3453 21-24 PR_EXT:000005904 denotes Crx
T3454 25-36 SO_EXT:0000673 denotes transcripts
T3455 49-58 GO:0010467 denotes expressed
T3456 73-87 CL:0000210 denotes photoreceptors
T3457 91-100 UBERON:0000922 denotes embryonic
T3458 125-130 NCBITaxon:10088 denotes mouse
T3459 144-156 GO_EXT:positive_regulation denotes upregulation
T3460 160-163 PR_EXT:000005904 denotes Crx
T3461 164-177 GO_EXT:transcription denotes transcription
T3462 201-216 GO_RO_EXT:developmental_differentiation_process denotes differentiating
T3463 217-231 CL:0000210 denotes photoreceptors
T3464 239-244 GO:0007567 denotes natal
T3465 257-276 CL:0000210 denotes Photoreceptor cells
T3466 271-276 CL_GO_EXT:cell denotes cells
T3467 284-287 PR_EXT:000005904 denotes Crx
T3468 302-306 NCBITaxon:10088 denotes mice
T3469 344-357 CL:0000210 denotes photoreceptor
T3470 358-367 CHEBI:36357 denotes molecules
T3471 378-384 GO:0007601 denotes visual
T3472 385-393 CHEBI_EXT:26130 denotes pigments
T3473 414-427 CL:0000210 denotes photoreceptor
T3474 414-442 GO:0001750 denotes photoreceptor outer segments
T3475 449-457 GO:0045202 denotes synaptic
T3476 458-466 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminus
T3477 488-497 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3478 501-506 NCBITaxon:9606 denotes human
T3479 507-510 PR_EXT:000005904 denotes CRX
T3480 571-584 CL:0000210 denotes photoreceptor
T3481 595-604 GO:0030849 denotes autosomal
T3482 614-618 CL:0000573 denotes cone
T3483 619-622 CL:0000604 denotes rod
T3484 636-645 GO:0030849 denotes autosomal
T3485 736-740 PR_EXT:000012086 denotes Otx2
T3486 745-748 PR_EXT:000005904 denotes Crx
T3487 749-756 GO:0065007 denotes control
T3488 765-778 CL:0000210 denotes photoreceptor
T3489 765-790 GO:0042461 denotes photoreceptor development
T3490 804-817 GO_EXT:transcription denotes transcription
T3491 804-825 GO_EXT:transcription_factor denotes transcription factors
T3492 827-831 PR_EXT:000016321 denotes TRβ2
T3493 833-836 PR_EXT:000011432 denotes Nrl
T3494 842-847 PR_EXT:000011403 denotes Nr2e3
T3495 848-856 GO:0065007 denotes regulate
T3496 878-896 CL:0000210 denotes photoreceptor cell
T3497 892-896 CL_GO_EXT:cell denotes cell
T3498 916-923 SO_EXT:0000417 denotes domains

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3264 21-24 PR:000005904 denotes Crx
T3265 25-36 SO:0000673 denotes transcripts
T3266 49-58 GO:0010467 denotes expressed
T3267 73-87 CL:0000210 denotes photoreceptors
T3268 91-100 UBERON:0000922 denotes embryonic
T3269 125-130 NCBITaxon:10088 denotes mouse
T3270 160-163 PR:000005904 denotes Crx
T3271 217-231 CL:0000210 denotes photoreceptors
T3272 239-244 GO:0007567 denotes natal
T3273 257-276 CL:0000210 denotes Photoreceptor cells
T3274 284-287 PR:000005904 denotes Crx
T3275 302-306 NCBITaxon:10088 denotes mice
T3276 344-357 CL:0000210 denotes photoreceptor
T3277 358-367 CHEBI:36357 denotes molecules
T3278 378-384 GO:0007601 denotes visual
T3279 385-393 CHEBI:26130 denotes pigments
T3280 414-427 CL:0000210 denotes photoreceptor
T3281 414-442 GO:0001750 denotes photoreceptor outer segments
T3282 449-457 GO:0045202 denotes synaptic
T3283 501-506 NCBITaxon:9606 denotes human
T3284 507-510 PR:000005904 denotes CRX
T3285 571-584 CL:0000210 denotes photoreceptor
T3286 595-604 GO:0030849 denotes autosomal
T3287 614-618 CL:0000573 denotes cone
T3288 619-622 CL:0000604 denotes rod
T3289 636-645 GO:0030849 denotes autosomal
T3290 736-740 PR:000012086 denotes Otx2
T3291 745-748 PR:000005904 denotes Crx
T3292 749-756 GO:0065007 denotes control
T3293 765-778 CL:0000210 denotes photoreceptor
T3294 765-790 GO:0042461 denotes photoreceptor development
T3295 827-831 PR:000016321 denotes TRβ2
T3296 833-836 PR:000011432 denotes Nrl
T3297 842-847 PR:000011403 denotes Nr2e3
T3298 848-856 GO:0065007 denotes regulate
T3299 878-896 CL:0000210 denotes photoreceptor cell
T3300 916-923 SO:0000417 denotes domains

craft-sa-dev

Id Subject Object Predicate Lexical cue
T3960 4-12 NNS denotes pathways
T3961 13-14 -LRB- denotes [
T3962 16-18 CD denotes 10
T3963 14-15 CD denotes 8
T3964 15-16 , denotes ,
T3965 18-19 -RRB- denotes ]
T3966 19-20 . denotes .
T3967 20-256 sentence denotes Crx transcripts begin to be expressed in developing photoreceptors at embryonic day 12.5 (E12.5) in the mouse and a strong upregulation of Crx transcription is apparent across the differentiating photoreceptors at postnatal day 6 (P6).
T3968 21-24 NN denotes Crx
T3969 25-36 NNS denotes transcripts
T3970 37-42 VBP denotes begin
T3971 43-45 TO denotes to
T3972 49-58 VBN denotes expressed
T3973 46-48 VB denotes be
T3974 59-61 IN denotes in
T3975 62-72 VBG denotes developing
T3976 73-87 NNS denotes photoreceptors
T3977 88-90 IN denotes at
T3978 91-100 JJ denotes embryonic
T3979 101-104 NN denotes day
T3980 105-109 CD denotes 12.5
T3981 110-111 -LRB- denotes (
T3982 111-116 NN denotes E12.5
T3983 116-117 -RRB- denotes )
T3984 118-120 IN denotes in
T3985 121-124 DT denotes the
T3986 125-130 NN denotes mouse
T3987 131-134 CC denotes and
T3988 135-136 DT denotes a
T3989 144-156 NN denotes upregulation
T3990 137-143 JJ denotes strong
T3991 178-180 VBZ denotes is
T3992 157-159 IN denotes of
T3993 160-163 NN denotes Crx
T3994 164-177 NN denotes transcription
T3995 181-189 JJ denotes apparent
T3996 190-196 IN denotes across
T3997 197-200 DT denotes the
T3998 217-231 NNS denotes photoreceptors
T3999 201-216 VBG denotes differentiating
T4000 232-234 IN denotes at
T4001 235-244 JJ denotes postnatal
T4002 245-248 NN denotes day
T4003 249-250 CD denotes 6
T4004 251-252 -LRB- denotes (
T4005 252-254 NN denotes P6
T4006 254-255 -RRB- denotes )
T4007 255-256 . denotes .
T4008 256-474 sentence denotes Photoreceptor cells in the Crx knockout (KO) mice exhibit a dramatic reduction of many photoreceptor molecules including visual pigments and develop neither photoreceptor outer segments nor a synaptic terminus [8,10].
T4009 257-270 NN denotes Photoreceptor
T4010 271-276 NNS denotes cells
T4011 307-314 VBP denotes exhibit
T4012 277-279 IN denotes in
T4013 280-283 DT denotes the
T4014 302-306 NNS denotes mice
T4015 284-287 NN denotes Crx
T4016 288-296 NN denotes knockout
T4017 297-298 -LRB- denotes (
T4018 298-300 NN denotes KO
T4019 300-301 -RRB- denotes )
T4020 315-316 DT denotes a
T4021 326-335 NN denotes reduction
T4022 317-325 JJ denotes dramatic
T4023 336-338 IN denotes of
T4024 339-343 JJ denotes many
T4025 358-367 NNS denotes molecules
T4026 344-357 NN denotes photoreceptor
T4027 368-377 VBG denotes including
T4028 378-384 JJ denotes visual
T4029 385-393 NNS denotes pigments
T4030 394-397 CC denotes and
T4031 398-405 VBP denotes develop
T4032 406-413 CC denotes neither
T4033 434-442 NNS denotes segments
T4034 414-427 NN denotes photoreceptor
T4035 428-433 JJ denotes outer
T4036 443-446 CC denotes nor
T4037 447-448 DT denotes a
T4038 458-466 NN denotes terminus
T4039 449-457 JJ denotes synaptic
T4040 467-468 -LRB- denotes [
T4041 470-472 CD denotes 10
T4042 468-469 CD denotes 8
T4043 469-470 , denotes ,
T4044 472-473 -RRB- denotes ]
T4045 473-474 . denotes .
T4046 474-729 sentence denotes In addition, mutations of human CRX have been demonstrated to be associated with three types of photoreceptor diseases: autosomal dominant cone-rod dystrophy 2, autosomal dominant-type retinitis pigmentosa, and Leber's congenital amaurosis (LCA) [11-14].
T4047 475-477 IN denotes In
T4048 521-533 VBN denotes demonstrated
T4049 478-486 NN denotes addition
T4050 486-488 , denotes ,
T4051 488-497 NNS denotes mutations
T4052 498-500 IN denotes of
T4053 501-506 JJ denotes human
T4054 507-510 NN denotes CRX
T4055 511-515 VBP denotes have
T4056 516-520 VBN denotes been
T4057 534-536 TO denotes to
T4058 540-550 VBN denotes associated
T4059 537-539 VB denotes be
T4060 551-555 IN denotes with
T4061 556-561 CD denotes three
T4062 562-567 NNS denotes types
T4063 568-570 IN denotes of
T4064 571-584 NN denotes photoreceptor
T4065 585-593 NNS denotes diseases
T4066 593-595 : denotes :
T4067 595-604 JJ denotes autosomal
T4068 605-613 JJ denotes dominant
T4069 623-632 NN denotes dystrophy
T4070 614-618 NN denotes cone
T4071 619-622 NN denotes rod
T4072 618-619 HYPH denotes -
T4073 633-634 CD denotes 2
T4074 634-636 , denotes ,
T4075 636-645 JJ denotes autosomal
T4076 646-654 JJ denotes dominant
T4077 655-659 NN denotes type
T4078 654-655 HYPH denotes -
T4079 670-680 NN denotes pigmentosa
T4080 660-669 NN denotes retinitis
T4081 680-682 , denotes ,
T4082 682-685 CC denotes and
T4083 686-691 NNP denotes Leber
T4084 705-714 NN denotes amaurosis
T4085 691-693 POS denotes 's
T4086 694-704 JJ denotes congenital
T4087 715-716 -LRB- denotes (
T4088 716-719 NN denotes LCA
T4089 719-720 -RRB- denotes )
T4090 721-722 -LRB- denotes [
T4091 722-724 CD denotes 11
T4092 724-725 SYM denotes -
T4093 725-727 CD denotes 14
T4094 727-728 -RRB- denotes ]
T4095 728-729 . denotes .
T4096 729-911 sentence denotes While Otx2 and Crx control general photoreceptor development, three other transcription factors, TRβ2, Nrl, and Nr2e3 regulate the specification of photoreceptor cell types [4,5,7].
T4097 730-735 IN denotes While
T4098 749-756 VBP denotes control
T4099 736-740 NN denotes Otx2
T4100 741-744 CC denotes and
T4101 745-748 NN denotes Crx
T4102 848-856 VBP denotes regulate
T4103 757-764 JJ denotes general
T4104 779-790 NN denotes development
T4105 765-778 NN denotes photoreceptor
T4106 790-792 , denotes ,
T4107 792-797 CD denotes three
T4108 818-825 NNS denotes factors
T4109 798-803 JJ denotes other
T4110 804-817 NN denotes transcription
T4111 825-827 , denotes ,
T4112 827-831 NN denotes TRβ2
T4113 831-833 , denotes ,
T4114 833-836 NN denotes Nrl
T4115 836-838 , denotes ,
T4116 838-841 CC denotes and
T4117 842-847 NN denotes Nr2e3
T4118 857-860 DT denotes the
T4119 861-874 NN denotes specification
T4120 875-877 IN denotes of
T4121 878-891 NN denotes photoreceptor
T4122 897-902 NNS denotes types
T4123 892-896 NN denotes cell
T4124 903-904 -LRB- denotes [
T4125 908-909 CD denotes 7
T4126 904-905 CD denotes 4
T4127 905-906 , denotes ,
T4128 906-907 CD denotes 5
T4129 907-908 , denotes ,
T4130 909-910 -RRB- denotes ]
T4131 910-911 . denotes .
T4133 912-915 NN denotes SAM
T4134 916-923 NNS denotes domains
T4136 924-925 -LRB- denotes (
R722 T3961 T3962 punct [,10
R724 T3963 T3962 nummod 8,10
R726 T3964 T3962 punct ",",10
R727 T3965 T3962 punct ],10
R730 T3968 T3969 compound Crx,transcripts
R731 T3969 T3970 nsubj transcripts,begin
R733 T3971 T3972 aux to,expressed
R735 T3972 T3970 xcomp expressed,begin
R736 T3973 T3972 auxpass be,expressed
R737 T3974 T3972 prep in,expressed
R738 T3975 T3976 amod developing,photoreceptors
R739 T3976 T3974 pobj photoreceptors,in
R741 T3977 T3972 prep at,expressed
R742 T3978 T3979 amod embryonic,day
R744 T3979 T3977 pobj day,at
R745 T3980 T3979 nummod 12.5,day
R746 T3981 T3979 punct (,day
R748 T3982 T3979 appos E12.5,day
R749 T3983 T3977 punct ),at
R750 T3984 T3972 prep in,expressed
R751 T3985 T3986 det the,mouse
R757 T3988 T3989 det a,upregulation
R759 T3990 T3989 amod strong,upregulation
R760 T3991 T3970 conj is,begin
R761 T3992 T3989 prep of,upregulation
R762 T3993 T3994 compound Crx,transcription
R763 T3994 T3992 pobj transcription,of
R765 T3995 T3991 acomp apparent,is
R766 T3996 T3991 prep across,is
R768 T3997 T3998 det the,photoreceptors
R769 T3998 T3996 pobj photoreceptors,across
R770 T3999 T3998 amod differentiating,photoreceptors
R772 T4000 T3991 prep at,is
R773 T4001 T4002 amod postnatal,day
R774 T4002 T4000 pobj day,at
R776 T4003 T4002 nummod 6,day
R777 T4004 T4002 punct (,day
R778 T4005 T4002 appos P6,day
R780 T4006 T3991 punct ),is
R781 T4007 T3991 punct .,is
R783 T4009 T4010 compound Photoreceptor,cells
R784 T4010 T4011 nsubj cells,exhibit
R786 T4012 T4010 prep in,cells
R787 T4013 T4014 det the,mice
R788 T4053 T4054 amod human,CRX
R789 T4014 T4012 pobj mice,in
R790 T4015 T4016 nmod Crx,knockout
R791 T4016 T4014 nmod knockout,mice
R792 T4017 T4016 punct (,knockout
R793 T4018 T4016 appos KO,knockout
R794 T4054 T4052 pobj CRX,of
R795 T4019 T4014 punct ),mice
R796 T4020 T4021 det a,reduction
R797 T4055 T4048 aux have,demonstrated
R798 T4021 T4011 dobj reduction,exhibit
R799 T4022 T4021 amod dramatic,reduction
R800 T4056 T4048 auxpass been,demonstrated
R801 T4023 T4021 prep of,reduction
R802 T4024 T4025 amod many,molecules
R803 T4025 T4023 pobj molecules,of
R804 T4026 T4025 compound photoreceptor,molecules
R805 T4057 T4058 aux to,associated
R806 T4027 T4025 prep including,molecules
R807 T4028 T4029 amod visual,pigments
R808 T4058 T4048 xcomp associated,demonstrated
R809 T4029 T4027 pobj pigments,including
R810 T4030 T4011 cc and,exhibit
R811 T4031 T4011 conj develop,exhibit
R812 T4032 T4033 preconj neither,segments
R813 T4033 T4031 dobj segments,develop
R814 T4034 T4033 nmod photoreceptor,segments
R815 T4035 T4033 amod outer,segments
R816 T4059 T4058 auxpass be,associated
R817 T4036 T4033 cc nor,segments
R818 T4037 T4038 det a,terminus
R819 T4038 T4033 conj terminus,segments
R820 T4060 T4058 prep with,associated
R821 T4039 T4038 amod synaptic,terminus
R822 T4040 T4041 punct [,10
R823 T4041 T4031 parataxis 10,develop
R824 T4061 T4062 nummod three,types
R825 T4042 T4041 nummod 8,10
R826 T4043 T4041 punct ",",10
R827 T4044 T4041 punct ],10
R828 T4062 T4060 pobj types,with
R829 T4045 T4011 punct .,exhibit
R830 T4063 T4062 prep of,types
R831 T4047 T4048 prep In,demonstrated
R832 T4049 T4047 pobj addition,In
R833 T4050 T4048 punct ", ",demonstrated
R834 T4064 T4065 compound photoreceptor,diseases
R835 T4051 T4048 nsubjpass mutations,demonstrated
R836 T4052 T4051 prep of,mutations
R837 T4065 T4063 pobj diseases,of
R838 T4066 T4062 punct : ,types
R839 T4067 T4068 amod autosomal,dominant
R840 T4068 T4069 amod dominant,dystrophy
R841 T4069 T4062 appos dystrophy,types
R844 T4070 T4071 compound cone,rod
R847 T4071 T4069 compound rod,dystrophy
R850 T4072 T4071 punct -,rod
R854 T4073 T4069 nummod 2,dystrophy
R856 T4074 T4069 punct ", ",dystrophy
R859 T4075 T4076 amod autosomal,dominant
R866 T4076 T4077 amod dominant,type
R871 T4077 T4079 compound type,pigmentosa
R875 T4078 T4077 punct -,type
R878 T4079 T4069 conj pigmentosa,dystrophy
R883 T4080 T4079 compound retinitis,pigmentosa
R886 T4081 T4079 punct ", ",pigmentosa
R890 T4082 T4079 cc and,pigmentosa
R894 T4083 T4084 poss Leber,amaurosis
R898 T4084 T4079 conj amaurosis,pigmentosa
R901 T4085 T4083 case 's,Leber
R905 T4086 T4084 amod congenital,amaurosis
R907 T4087 T4084 punct (,amaurosis
R912 T4088 T4084 appos LCA,amaurosis
R919 T4089 T4048 punct ),demonstrated
R923 T4090 T4091 punct [,11
R927 T4091 T4048 parataxis 11,demonstrated
R931 T4092 T4093 punct -,14
R935 T4093 T4091 prep 14,11
R938 T4094 T4091 punct ],11
R943 T4095 T4048 punct .,demonstrated
R946 T4097 T4098 mark While,control
R949 T4098 T4102 advcl control,regulate
R953 T4099 T4098 nsubj Otx2,control
R957 T4100 T4099 cc and,Otx2
R959 T4101 T4099 conj Crx,Otx2
R964 T4103 T4104 amod general,development
R970 T4104 T4098 dobj development,control
R974 T4105 T4104 compound photoreceptor,development
R976 T4106 T4102 punct ", ",regulate
R977 T4107 T4108 nummod three,factors
R978 T4108 T4102 nsubj factors,regulate
R979 T4109 T4108 amod other,factors
R982 T4110 T4108 compound transcription,factors
R985 T4111 T4108 punct ", ",factors
R988 T4112 T4108 appos TRβ2,factors
R992 T4113 T4112 punct ", ",TRβ2
R995 T4114 T4112 conj Nrl,TRβ2
R998 T4115 T4114 punct ", ",Nrl
R1001 T4116 T4114 cc and,Nrl
R1005 T4117 T4114 conj Nr2e3,Nrl
R1008 T4118 T4119 det the,specification
R1012 T4119 T4102 dobj specification,regulate
R1015 T4120 T4119 prep of,specification
R1017 T4121 T4122 compound photoreceptor,types
R1024 T4122 T4120 pobj types,of
R1028 T4123 T4122 compound cell,types
R1032 T4124 T4125 punct [,7
R1034 T4125 T4102 parataxis 7,regulate
R1037 T4126 T4125 nummod 4,7
R1041 T4127 T4125 punct ",",7
R1044 T4128 T4125 nummod 5,7
R1048 T4129 T4125 punct ",",7
R1052 T4130 T4125 punct ],7
R1055 T4131 T4102 punct .,regulate
R1059 T4133 T4134 compound SAM,domains
R1064 T4136 T4134 punct (,domains
R754 T3986 T3984 pobj mouse,in
R755 T3987 T3970 cc and,begin
R758 T3989 T3991 nsubj upregulation,is