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PMC:1435744 / 31437-39740 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T20363 55-59 SO_EXT:0000704 denotes gene
T20364 61-65 PR_EXT:000014441 denotes mr-s
T20365 90-99 GO:0010467 denotes expressed
T20366 103-110 UBERON:0000966 denotes retinal
T20367 103-125 CL:0010009 denotes retinal photoreceptors
T20368 134-146 UBERON:0001905 denotes pineal gland
T20369 160-164 PR_EXT:000014441 denotes mr-s
T20370 165-175 GO:0010467 denotes expression
T20371 194-200 UBERON:0000966 denotes retina
T20372 220-230 GO:0010467 denotes expression
T20373 277-280 PR_EXT:000005904 denotes Crx
T20374 282-291 PR_EXT:000001245 denotes rhodopsin
T20375 302-315 CL:0000210 denotes photoreceptor
T20376 316-321 SO_EXT:0000704 denotes genes
T20377 351-372 UBERON:0001790 denotes outer plexiform layer
T20378 403-418 UBERON:0001781 denotes layer of retina
T20379 446-449 UBERON:0001789 denotes ONL
T20380 454-457 UBERON:0001791 denotes INL
T20381 477-491 CL:0000210 denotes photoreceptors
T20382 518-533 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T20383 547-560 GO:0001750 denotes outer segment
T20384 593-597 PR_EXT:000014441 denotes mr-s
T20385 607-615 CHEBI:36357 denotes molecule
T20386 628-657 GO:0042461 denotes development of photoreceptors
T20387 643-657 CL:0000210 denotes photoreceptors
T20388 687-691 PR_EXT:000012086 denotes Otx2
T20389 696-699 PR_EXT:000005904 denotes Crx
T20390 724-737 CL:0000210 denotes photoreceptor
T20391 724-749 GO:0042461 denotes photoreceptor development
T20392 759-763 PR_EXT:000012086 denotes Otx2
T20393 773-782 GO:0065007 denotes regulates
T20394 783-786 PR_EXT:000005904 denotes Crx
T20395 787-800 GO_EXT:transcription denotes transcription
T20396 816-829 GO:0097617 denotes hybridization
T20397 834-836 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T20398 873-877 PR_EXT:000014441 denotes mr-s
T20399 892-895 PR_EXT:000005904 denotes Crx
T20400 899-905 UBERON:0000966 denotes retina
T20401 910-922 UBERON:0001905 denotes pineal gland
T20402 941-951 GO_EXT:0045289 denotes luciferase
T20403 976-980 PR_EXT:000012086 denotes Otx2
T20404 985-988 PR_EXT:000005904 denotes Crx
T20405 1002-1012 GO_EXT:positive_regulation denotes upregulate
T20406 1017-1030 GO_EXT:transcription denotes transcription
T20407 1034-1038 PR_EXT:000014441 denotes mr-s
T20408 1042-1051 NCBITaxon:40674 denotes mammalian
T20409 1052-1057 CL_GO_EXT:cell denotes cells
T20410 1062-1069 UBERON:0000966 denotes retinal
T20411 1062-1089 CL:0010009 denotes retinal photoreceptor cells
T20412 1084-1089 CL_GO_EXT:cell denotes cells
T20413 1095-1099 PR_EXT:000012086 denotes Otx2
T20414 1100-1111 SO_EXT:0000673 denotes transcripts
T20415 1127-1136 GO:0010467 denotes expressed
T20416 1157-1160 PR_EXT:000005904 denotes Crx
T20417 1161-1172 SO_EXT:0000673 denotes transcripts
T20418 1251-1255 PR_EXT:000014441 denotes mr-s
T20419 1256-1269 GO_EXT:transcription denotes transcription
T20420 1282-1291 GO:0065007 denotes regulated
T20421 1295-1298 PR_EXT:000005904 denotes Crx
T20422 1322-1325 PR_EXT:000011432 denotes Nrl
T20423 1329-1342 CL:0000210 denotes photoreceptor
T20424 1352-1365 GO_EXT:transcription denotes transcription
T20425 1352-1372 GO_EXT:transcription_factor denotes transcription factor
T20426 1388-1397 GO:0010467 denotes expressed
T20427 1401-1415 CL:0000210 denotes photoreceptors
T20428 1427-1432 GO:0007567 denotes natal
T20429 1459-1472 GO_EXT:transcription denotes transcription
T20430 1476-1480 PR_EXT:000014441 denotes mr-s
T20431 1543-1546 PR_EXT:000011432 denotes Nrl
T20432 1550-1555 NCBITaxon:10088 denotes mouse
T20433 1594-1604 GO:0010467 denotes expression
T20434 1617-1626 SO_EXT:wild_type_entity_or_quality denotes wild-type
T20435 1631-1634 PR_EXT:000011432 denotes Nrl
T20436 1638-1645 UBERON:0000966 denotes retinas
T20437 1688-1692 PR_EXT:000014441 denotes mr-s
T20438 1732-1741 GO:0010467 denotes expressed
T20439 1742-1747 SO_EXT:0000704 denotes genes
T20440 1755-1758 PR_EXT:000011432 denotes Nrl
T20441 1762-1768 UBERON:0000966 denotes retina
T20442 1810-1816 SO_EXT:0000417 denotes domain
T20443 1822-1829 CHEBI_PR_EXT:protein denotes protein
T20444 1830-1837 CHEBI_PR_EXT:protein denotes protein
T20445 1850-1856 SO_EXT:0000417 denotes module
T20446 1866-1872 SO_EXT:0000417 denotes domain
T20447 1880-1884 PR_EXT:000014441 denotes mr-s
T20448 1885-1892 CHEBI_PR_EXT:protein denotes protein
T20449 1930-1933 PR_EXT:000007229 denotes TEL
T20450 1945-1952 SO_EXT:0000417 denotes domains
T20451 1964-1971 SO_EXT:0001114 denotes helical
T20452 1986-1995 CHEBI:33839 denotes polymeric
T20453 2050-2059 GO:0000785 denotes chromatin
T20454 2091-2102 CHEBI_EXT:biochemical denotes biochemical
T20455 2115-2119 PR_EXT:000014441 denotes mr-s
T20456 2134-2139 NCBITaxon_EXT:yeast denotes yeast
T20457 2179-2183 PR_EXT:000014441 denotes mr-s
T20458 2237-2243 SO_EXT:sequence_cloned_entity denotes clones
T20459 2277-2281 SO_EXT:cDNA denotes cDNA
T20460 2311-2317 SO_EXT:0000417 denotes domain
T20461 2321-2325 PR_EXT:000014441 denotes mr-s
T20462 2355-2359 PR_EXT:000014441 denotes mr-s
T20463 2392-2398 SO_EXT:0000417 denotes domain
T20464 2445-2453 GO_EXT:biological_direction_or_guidance denotes directed
T20465 2454-2461 SO_EXT:sequence_altered_entity denotes mutants
T20466 2473-2479 SO_EXT:0000417 denotes domain
T20467 2483-2487 PR_EXT:000014441 denotes mr-s
T20468 2511-2515 PR_EXT:000014441 denotes mr-s
T20469 2516-2523 CHEBI_PR_EXT:protein denotes protein
T20470 2559-2565 SO_EXT:0000417 denotes domain
T20471 2569-2578 NCBITaxon:40674 denotes mammalian
T20472 2579-2584 CL_GO_EXT:cell denotes cells
T20473 2640-2646 SO_EXT:0000417 denotes domain
T20474 2650-2654 PR_EXT:000014441 denotes mr-s
T20475 2663-2672 CHEBI:33839 denotes polymeric
T20476 2738-2744 SO_EXT:0000417 denotes domain
T20477 2748-2752 PR_EXT:000014441 denotes mr-s
T20478 2767-2773 SO_EXT:0000417 denotes domain
T20479 2785-2794 CHEBI:36357 denotes molecules
T20480 2809-2813 PR_EXT:000014441 denotes mr-s
T20481 2836-2843 CHEBI:33839 denotes polymer
T20482 2856-2860 SO_EXT:0000704 denotes gene
T20483 2856-2870 GO:0016458 denotes gene silencing
T20484 2895-2904 GO:0032991 denotes complexes
T20485 2915-2924 GO:0000785 denotes chromatin
T20486 2946-2949 PR_EXT:000007229 denotes TEL
T20487 3027-3037 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T20488 3038-3048 SO_EXT:engineered_biological_sequence denotes constructs
T20489 3063-3069 SO_EXT:0000417 denotes domain
T20490 3149-3156 CHEBI:33839 denotes polymer
T20491 3217-3224 CHEBI_PR_EXT:protein denotes protein
T20492 3225-3232 CHEBI_PR_EXT:protein denotes protein
T20493 3248-3252 PR_EXT:000014441 denotes mr-s
T20494 3279-3289 GO:0010467 denotes expression
T20495 3330-3334 PR_EXT:000014441 denotes mr-s
T20496 3343-3350 CHEBI:33839 denotes polymer
T20497 3408-3411 PR_EXT:000007229 denotes TEL
T20498 3423-3431 SO_EXT:biological_sequence denotes sequence
T20499 3441-3444 CHEBI_SO_EXT:DNA denotes DNA
T20500 3445-3452 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T20501 3453-3459 SO_EXT:0000417 denotes domain
T20502 3476-3482 SO_EXT:0000417 denotes domain
T20503 3488-3493 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T20504 3524-3530 SO_EXT:0000417 denotes domain
T20505 3537-3540 PR_EXT:000007229 denotes TEL
T20506 3567-3574 CHEBI:33839 denotes polymer
T20507 3598-3613 GO:0051259 denotes oligomerization
T20508 3625-3631 SO_EXT:0000417 denotes domain
T20509 3648-3651 PR_EXT:000007229 denotes TEL
T20510 3684-3692 SO_EXT:biological_sequence denotes sequence
T20511 3702-3705 CHEBI_SO_EXT:DNA denotes DNA
T20512 3706-3713 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T20513 3714-3719 SO_EXT:sequence_or_structure_motif denotes motif
T20514 3749-3756 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T20515 3785-3792 CHEBI_PR_EXT:protein denotes protein
T20516 3793-3800 CHEBI_PR_EXT:protein denotes protein
T20517 3825-3833 SO_EXT:biological_sequence denotes sequence
T20518 3843-3858 GO_EXT:transcription denotes transcriptional
T20519 3888-3892 SO_EXT:0000704 denotes gene
T20520 3893-3901 SO_EXT:sequence_coding_function denotes encoding
T20521 3902-3917 GO_EXT:transcription denotes transcriptional
T20522 3937-3946 PR_EXT:P05084 denotes Hunchback
T20523 3962-3972 GO_EXT:biological_recruitment denotes recruiting
T20524 3977-3983 SO_EXT:0000417 denotes domain
T20525 3999-4007 CHEBI_PR_EXT:protein denotes proteins
T20526 4049-4063 MOP:0000629 denotes polymerization
T20527 4076-4080 PR_EXT:000014441 denotes mr-s
T20528 4106-4109 CHEBI_SO_EXT:DNA denotes DNA
T20529 4110-4117 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T20530 4118-4124 SO_EXT:sequence_or_structure_motif denotes motifs
T20531 4153-4161 SO_EXT:biological_sequence denotes sequence
T20532 4171-4184 GO_EXT:transcription denotes transcription
T20533 4171-4194 GO_EXT:transcription_factor denotes transcription factor(s)
T20534 4216-4220 PR_EXT:000014441 denotes mr-s
T20535 4251-4264 GO_EXT:transcription denotes transcription
T20536 4251-4272 GO_EXT:transcription_factor denotes transcription factors
T20537 4288-4293 NCBITaxon_EXT:yeast denotes yeast
T20538 4347-4351 PR_EXT:000014441 denotes mr-s
T20539 4352-4357 SO_EXT:sequence_fusion_process denotes fused
T20540 4365-4369 PR_EXT:P04386 denotes GAL4
T20541 4370-4373 CHEBI_SO_EXT:DNA denotes DNA
T20542 4374-4381 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T20543 4382-4388 SO_EXT:0000417 denotes domain
T20544 4394-4397 PR_EXT:000014441 denotes mrs
T20545 4414-4429 GO_EXT:transcription denotes transcriptional
T20546 4472-4476 PR_EXT:000014441 denotes mr-s
T20547 4503-4512 GO:0032991 denotes complexes
T20548 4534-4540 SO_EXT:0000417 denotes domain
T20549 4552-4560 CHEBI_PR_EXT:protein denotes proteins
T20550 4620-4624 PR_EXT:000014441 denotes mr-s
T20551 4641-4647 SO_EXT:0000417 denotes domain
T20552 4673-4688 GO_EXT:transcription denotes transcriptional
T20553 4710-4724 MOP:0000629 denotes Polymerization
T20554 4736-4742 SO_EXT:0000417 denotes domain
T20555 4827-4830 PR_EXT:000007229 denotes TEL
T20556 4859-4864 NCBITaxon:9606 denotes human
T20557 4865-4871 GO_EXT:fatality_or_lethality denotes lethal
T20558 4865-4896 PR_EXT:000009640 denotes lethal(3) malignant brain tumor
T20559 4885-4890 UBERON:0000955 denotes brain
T20560 4900-4907 PR_EXT:000009640 denotes L(3)MBT
T20561 4909-4916 CHEBI_PR_EXT:protein denotes protein
T20562 4944-4950 SO_EXT:0000417 denotes domain
T20563 4958-4968 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminus
T20564 4988-5003 GO_EXT:transcription denotes transcriptional
T20565 5044-5045 NCBITaxon:9606 denotes H
T20566 5046-5053 PR_EXT:000009640 denotes L(3)MBT
T20567 5094-5101 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T20568 5118-5124 SO_EXT:0000417 denotes domain
T20569 5148-5163 GO_EXT:transcription denotes transcriptional
T20570 5188-5192 PR_EXT:000014441 denotes mr-s
T20571 5193-5200 CHEBI_PR_EXT:protein denotes protein
T20572 5217-5227 GO_EXT:0045289 denotes luciferase
T20573 5245-5253 GO_EXT:biological_direction_or_guidance denotes directed
T20574 5254-5261 SO_EXT:sequence_altered_entity denotes mutants
T20575 5324-5331 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T20576 5386-5401 GO_EXT:transcription denotes transcriptional
T20577 5425-5429 PR_EXT:000014441 denotes mr-s
T20578 5535-5541 SO_EXT:0000417 denotes domain
T20579 5591-5598 SO_EXT:0000155 denotes plasmid
T20580 5642-5653 CHEBI_SO_EXT:amino_acid denotes amino acids
T20581 5729-5733 PR_EXT:000014441 denotes mr-s
T20582 5735-5760 SO_EXT:biological_conservation_process_or_quality denotes Evolutionary conservation
T20583 5768-5778 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T20584 5782-5784 CHEBI_SO_EXT:amino_acid denotes aa
T20585 5795-5799 PR_EXT:000014441 denotes mr-s
T20586 5805-5814 NCBITaxon:7955 denotes zebrafish
T20587 5823-5828 NCBITaxon:9606 denotes human
T20588 5902-5909 CHEBI_PR_EXT:protein denotes protein
T20589 5910-5923 GO:0031519 denotes PcG complexes
T20590 5925-5929 GO:0035102 denotes PRC1
T20591 5934-5938 GO:0035098 denotes PRC2
T20592 5962-5966 GO:0035098 denotes PRC2
T20593 6000-6009 GO:0016458 denotes silencing
T20594 6023-6030 PR_EXT:000043452 denotes histone
T20595 6023-6030 CHEBI:15358 denotes histone
T20596 6023-6043 GO_EXT:0004407 denotes histone deacetylases
T20597 6045-6050 GO_EXT:0004407 denotes HDACs
T20598 6056-6063 PR_EXT:000043452 denotes histone
T20599 6056-6063 CHEBI:15358 denotes histone
T20600 6056-6082 GO_EXT:0042054 denotes histone methyltransferases
T20601 6094-6103 GO_MOP_EXT:methylation denotes methylate
T20602 6104-6111 CHEBI:15358 denotes histone
T20603 6104-6114 PR_EXT:000027594 denotes histone H3
T20604 6115-6121 CHEBI_SO_EXT:lysine denotes lysine
T20605 6132-6137 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marks
T20606 6141-6149 GO:0016458 denotes silenced
T20607 6141-6159 GO:0035328 denotes silenced chromatin
T20608 6161-6165 GO:0035102 denotes PRC1
T20609 6196-6203 CHEBI:15358 denotes histone
T20610 6196-6206 PR_EXT:000027594 denotes histone H3
T20611 6207-6213 CHEBI_SO_EXT:lysine denotes lysine
T20612 6217-6221 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes mark
T20613 6229-6233 GO:0035098 denotes PRC2
T20614 6266-6270 SO_EXT:0000704 denotes gene
T20615 6291-6295 GO:0035102 denotes PRC1
T20616 6303-6312 GO:0000785 denotes chromatin
T20617 6303-6323 GO:0006338 denotes chromatin remodeling
T20618 6355-6370 GO:0016514 denotes SWI-SNF complex
T20619 6422-6426 GO:0035098 denotes PRC2
T20620 6444-6448 GO_EXT:0004407 denotes HDAC
T20621 6496-6500 GO:0035102 denotes PRC1
T20622 6515-6519 GO_EXT:0004407 denotes HDAC
T20623 6537-6547 GO_EXT:0045289 denotes luciferase
T20624 6571-6586 GO_EXT:transcription denotes transcriptional
T20625 6605-6608 PR_EXT:000014441 denotes mrs
T20626 6671-6685 CHEBI:46024 denotes trichostatin A
T20627 6696-6710 CHEBI_GO_EXT:histone_deacetylase_inhibitor denotes HDAC inhibitor
T20628 6789-6793 PR_EXT:000014441 denotes mr-s
T20629 6801-6805 GO_EXT:0004407 denotes HDAC
T20630 6846-6858 GO:0035102 denotes PRC1 complex
T20631 6886-6897 CHEBI_EXT:biochemical denotes biochemical
T20632 6931-6935 PR_EXT:000014441 denotes mr-s
T20633 6936-6943 CHEBI_PR_EXT:protein denotes protein
T20634 6959-6974 GO_EXT:transcription denotes transcriptional
T20635 6998-7012 GO_EXT:negative_regulation denotes down-regulates
T20636 7038-7048 GO:0010467 denotes expression
T20637 7063-7068 SO_EXT:0000704 denotes genes
T20638 7076-7083 UBERON:0000966 denotes retinal
T20639 7076-7097 CL:0010009 denotes retinal photoreceptor
T20640 7084-7109 GO:0042461 denotes photoreceptor development
T20641 7166-7170 PR_EXT:000014441 denotes mr-s
T20642 7192-7202 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T20643 7211-7222 CHEBI_SO_EXT:amino_acid denotes amino acids
T20644 7267-7271 PR_EXT:000014441 denotes mr-s
T20645 7302-7315 GO:0097617 denotes hybridization
T20646 7340-7344 PR_EXT:000014441 denotes mr-s
T20647 7345-7355 GO:0010467 denotes expression
T20648 7375-7382 UBERON:0000966 denotes retinal
T20649 7375-7397 CL:0010009 denotes retinal photoreceptors
T20650 7415-7430 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T20651 7463-7468 SO_EXT:0000704 denotes genes
T20652 7472-7476 PR_EXT:000014441 denotes mr-s
T20653 7490-7503 CL:0000210 denotes photoreceptor
T20654 7504-7509 SO_EXT:0000704 denotes genes
T20655 7525-7529 PR_EXT:000014441 denotes mr-s
T20656 7547-7557 GO:0010467 denotes expression
T20657 7565-7578 CL:0000210 denotes photoreceptor
T20658 7579-7584 SO_EXT:0000704 denotes genes
T20659 7588-7591 _FRAGMENT denotes rod
T20660 7601-7615 CL:0000604 denotes photoreceptors
T20661 7596-7615 CL:0000573 denotes cone photoreceptors
T20662 7655-7659 PR_EXT:000014441 denotes mr-s
T20663 7675-7679 CL_GO_EXT:cell denotes cell
T20664 7675-7701 _FRAGMENT denotes cell fate determination of
T20665 7706-7720 GO:0043703 denotes photoreceptors
T20666 7728-7747 GO:0042671 denotes cone photoreceptors
T20667 7702-7720 CL:0000604 denotes rod photoreceptors
T20668 7728-7747 CL:0000573 denotes cone photoreceptors
T20669 7755-7774 CL:0000573 denotes cone photoreceptors
T20670 7795-7810 UBERON:0019248 denotes early embryonic
T20671 7801-7817 UBERON_EXT:embryonic_stage_or_stage_part denotes embryonic stages
T20672 7821-7826 NCBITaxon:10088 denotes mouse
T20673 7827-7840 GO:0060041 denotes retinogenesis
T20674 7842-7860 CL:0000604 denotes rod photoreceptors
T20675 7887-7901 _FRAGMENT denotes late embryonic
T20676 7922-7928 UBERON:0007220 denotes period
T20679 7961-7965 PR_EXT:000014441 denotes mr-s
T20680 7983-7987 PR_EXT:000014441 denotes mr-s
T20681 7991-8000 GO:0010467 denotes expressed
T20682 8004-8022 CL:0000604 denotes rod photoreceptors
T20683 8034-8053 CL:0000573 denotes cone photoreceptors
T20684 8065-8070 PR_EXT:000011403 denotes Nr2e3
T20677 7916-7921 GO:0007567 denotes natal
T20678 7939-7949 GO:0010467 denotes expression
T20685 8092-8107 GO_EXT:transcription denotes transcriptional
T20686 8136-8149 GO_EXT:negative_regulation denotes down-regulate
T20687 8150-8168 CL:0000573 denotes cone photoreceptor
T20688 8178-8183 SO_EXT:0000704 denotes genes
T20689 8200-8210 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T20690 8223-8227 PR_EXT:000014441 denotes mr-s
T20691 8241-8245 NCBITaxon:10088 denotes mice
T20692 8275-8279 PR_EXT:000014441 denotes mr-s
R4871 T20660 T20659 _lexicallyChainedTo photoreceptors,rod
R4872 T20665 T20664 _lexicallyChainedTo photoreceptors,cell fate determination of
R4873 T20666 T20664 _lexicallyChainedTo cone photoreceptors,cell fate determination of
R4874 T20676 T20675 _lexicallyChainedTo period,late embryonic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T20136 55-59 SO:0000704 denotes gene
T20137 61-65 PR:000014441 denotes mr-s
T20138 90-99 GO:0010467 denotes expressed
T20139 103-110 UBERON:0000966 denotes retinal
T20140 103-125 CL:0010009 denotes retinal photoreceptors
T20141 134-146 UBERON:0001905 denotes pineal gland
T20142 160-164 PR:000014441 denotes mr-s
T20143 165-175 GO:0010467 denotes expression
T20144 194-200 UBERON:0000966 denotes retina
T20145 220-230 GO:0010467 denotes expression
T20146 277-280 PR:000005904 denotes Crx
T20147 282-291 PR:000001245 denotes rhodopsin
T20148 302-315 CL:0000210 denotes photoreceptor
T20149 316-321 SO:0000704 denotes genes
T20150 351-372 UBERON:0001790 denotes outer plexiform layer
T20151 403-418 UBERON:0001781 denotes layer of retina
T20152 446-449 UBERON:0001789 denotes ONL
T20153 454-457 UBERON:0001791 denotes INL
T20154 477-491 CL:0000210 denotes photoreceptors
T20155 547-560 GO:0001750 denotes outer segment
T20156 593-597 PR:000014441 denotes mr-s
T20157 607-615 CHEBI:36357 denotes molecule
T20158 628-657 GO:0042461 denotes development of photoreceptors
T20159 643-657 CL:0000210 denotes photoreceptors
T20160 687-691 PR:000012086 denotes Otx2
T20161 696-699 PR:000005904 denotes Crx
T20162 724-737 CL:0000210 denotes photoreceptor
T20163 724-749 GO:0042461 denotes photoreceptor development
T20164 759-763 PR:000012086 denotes Otx2
T20165 773-782 GO:0065007 denotes regulates
T20166 783-786 PR:000005904 denotes Crx
T20167 816-829 GO:0097617 denotes hybridization
T20168 873-877 PR:000014441 denotes mr-s
T20169 892-895 PR:000005904 denotes Crx
T20170 899-905 UBERON:0000966 denotes retina
T20171 910-922 UBERON:0001905 denotes pineal gland
T20172 976-980 PR:000012086 denotes Otx2
T20173 985-988 PR:000005904 denotes Crx
T20174 1034-1038 PR:000014441 denotes mr-s
T20175 1042-1051 NCBITaxon:40674 denotes mammalian
T20176 1062-1069 UBERON:0000966 denotes retinal
T20177 1062-1089 CL:0010009 denotes retinal photoreceptor cells
T20178 1095-1099 PR:000012086 denotes Otx2
T20179 1100-1111 SO:0000673 denotes transcripts
T20180 1127-1136 GO:0010467 denotes expressed
T20181 1157-1160 PR:000005904 denotes Crx
T20182 1161-1172 SO:0000673 denotes transcripts
T20183 1251-1255 PR:000014441 denotes mr-s
T20184 1282-1291 GO:0065007 denotes regulated
T20185 1295-1298 PR:000005904 denotes Crx
T20186 1322-1325 PR:000011432 denotes Nrl
T20187 1329-1342 CL:0000210 denotes photoreceptor
T20188 1388-1397 GO:0010467 denotes expressed
T20189 1401-1415 CL:0000210 denotes photoreceptors
T20190 1427-1432 GO:0007567 denotes natal
T20191 1476-1480 PR:000014441 denotes mr-s
T20192 1543-1546 PR:000011432 denotes Nrl
T20193 1550-1555 NCBITaxon:10088 denotes mouse
T20194 1594-1604 GO:0010467 denotes expression
T20195 1631-1634 PR:000011432 denotes Nrl
T20196 1638-1645 UBERON:0000966 denotes retinas
T20197 1688-1692 PR:000014441 denotes mr-s
T20198 1732-1741 GO:0010467 denotes expressed
T20199 1742-1747 SO:0000704 denotes genes
T20200 1755-1758 PR:000011432 denotes Nrl
T20201 1762-1768 UBERON:0000966 denotes retina
T20202 1810-1816 SO:0000417 denotes domain
T20203 1850-1856 SO:0000417 denotes module
T20204 1866-1872 SO:0000417 denotes domain
T20205 1880-1884 PR:000014441 denotes mr-s
T20206 1930-1933 PR:000007229 denotes TEL
T20207 1945-1952 SO:0000417 denotes domains
T20208 1964-1971 SO:0001114 denotes helical
T20209 1986-1995 CHEBI:33839 denotes polymeric
T20210 2050-2059 GO:0000785 denotes chromatin
T20211 2115-2119 PR:000014441 denotes mr-s
T20212 2179-2183 PR:000014441 denotes mr-s
T20213 2311-2317 SO:0000417 denotes domain
T20214 2321-2325 PR:000014441 denotes mr-s
T20215 2355-2359 PR:000014441 denotes mr-s
T20216 2392-2398 SO:0000417 denotes domain
T20217 2473-2479 SO:0000417 denotes domain
T20218 2483-2487 PR:000014441 denotes mr-s
T20219 2511-2515 PR:000014441 denotes mr-s
T20220 2559-2565 SO:0000417 denotes domain
T20221 2569-2578 NCBITaxon:40674 denotes mammalian
T20222 2640-2646 SO:0000417 denotes domain
T20223 2650-2654 PR:000014441 denotes mr-s
T20224 2663-2672 CHEBI:33839 denotes polymeric
T20225 2738-2744 SO:0000417 denotes domain
T20226 2748-2752 PR:000014441 denotes mr-s
T20227 2767-2773 SO:0000417 denotes domain
T20228 2785-2794 CHEBI:36357 denotes molecules
T20229 2809-2813 PR:000014441 denotes mr-s
T20230 2836-2843 CHEBI:33839 denotes polymer
T20231 2856-2860 SO:0000704 denotes gene
T20232 2856-2870 GO:0016458 denotes gene silencing
T20233 2895-2904 GO:0032991 denotes complexes
T20234 2915-2924 GO:0000785 denotes chromatin
T20235 2946-2949 PR:000007229 denotes TEL
T20236 3063-3069 SO:0000417 denotes domain
T20237 3149-3156 CHEBI:33839 denotes polymer
T20238 3248-3252 PR:000014441 denotes mr-s
T20239 3279-3289 GO:0010467 denotes expression
T20240 3330-3334 PR:000014441 denotes mr-s
T20241 3343-3350 CHEBI:33839 denotes polymer
T20242 3408-3411 PR:000007229 denotes TEL
T20243 3453-3459 SO:0000417 denotes domain
T20244 3476-3482 SO:0000417 denotes domain
T20245 3524-3530 SO:0000417 denotes domain
T20246 3537-3540 PR:000007229 denotes TEL
T20247 3567-3574 CHEBI:33839 denotes polymer
T20248 3598-3613 GO:0051259 denotes oligomerization
T20249 3625-3631 SO:0000417 denotes domain
T20250 3648-3651 PR:000007229 denotes TEL
T20251 3888-3892 SO:0000704 denotes gene
T20252 3937-3946 PR:P05084 denotes Hunchback
T20253 3977-3983 SO:0000417 denotes domain
T20254 4049-4063 MOP:0000629 denotes polymerization
T20255 4076-4080 PR:000014441 denotes mr-s
T20256 4216-4220 PR:000014441 denotes mr-s
T20257 4347-4351 PR:000014441 denotes mr-s
T20258 4365-4369 PR:P04386 denotes GAL4
T20259 4382-4388 SO:0000417 denotes domain
T20260 4394-4397 PR:000014441 denotes mrs
T20261 4472-4476 PR:000014441 denotes mr-s
T20262 4503-4512 GO:0032991 denotes complexes
T20263 4534-4540 SO:0000417 denotes domain
T20264 4620-4624 PR:000014441 denotes mr-s
T20265 4641-4647 SO:0000417 denotes domain
T20266 4710-4724 MOP:0000629 denotes Polymerization
T20267 4736-4742 SO:0000417 denotes domain
T20268 4827-4830 PR:000007229 denotes TEL
T20269 4859-4864 NCBITaxon:9606 denotes human
T20270 4865-4896 PR:000009640 denotes lethal(3) malignant brain tumor
T20271 4885-4890 UBERON:0000955 denotes brain
T20272 4900-4907 PR:000009640 denotes L(3)MBT
T20273 4944-4950 SO:0000417 denotes domain
T20274 5044-5045 NCBITaxon:9606 denotes H
T20275 5046-5053 PR:000009640 denotes L(3)MBT
T20276 5118-5124 SO:0000417 denotes domain
T20277 5188-5192 PR:000014441 denotes mr-s
T20278 5425-5429 PR:000014441 denotes mr-s
T20279 5535-5541 SO:0000417 denotes domain
T20280 5591-5598 SO:0000155 denotes plasmid
T20281 5729-5733 PR:000014441 denotes mr-s
T20282 5795-5799 PR:000014441 denotes mr-s
T20283 5805-5814 NCBITaxon:7955 denotes zebrafish
T20284 5823-5828 NCBITaxon:9606 denotes human
T20285 5910-5923 GO:0031519 denotes PcG complexes
T20286 5925-5929 GO:0035102 denotes PRC1
T20287 5934-5938 GO:0035098 denotes PRC2
T20288 5962-5966 GO:0035098 denotes PRC2
T20289 6000-6009 GO:0016458 denotes silencing
T20290 6023-6030 PR:000043452 denotes histone
T20291 6023-6030 CHEBI:15358 denotes histone
T20292 6056-6063 PR:000043452 denotes histone
T20293 6056-6063 CHEBI:15358 denotes histone
T20294 6104-6111 CHEBI:15358 denotes histone
T20295 6104-6114 PR:000027594 denotes histone H3
T20296 6141-6149 GO:0016458 denotes silenced
T20297 6141-6159 GO:0035328 denotes silenced chromatin
T20298 6161-6165 GO:0035102 denotes PRC1
T20299 6196-6203 CHEBI:15358 denotes histone
T20300 6196-6206 PR:000027594 denotes histone H3
T20301 6229-6233 GO:0035098 denotes PRC2
T20302 6266-6270 SO:0000704 denotes gene
T20303 6291-6295 GO:0035102 denotes PRC1
T20304 6303-6312 GO:0000785 denotes chromatin
T20305 6303-6323 GO:0006338 denotes chromatin remodeling
T20306 6355-6370 GO:0016514 denotes SWI-SNF complex
T20307 6422-6426 GO:0035098 denotes PRC2
T20308 6496-6500 GO:0035102 denotes PRC1
T20309 6605-6608 PR:000014441 denotes mrs
T20310 6671-6685 CHEBI:46024 denotes trichostatin A
T20311 6789-6793 PR:000014441 denotes mr-s
T20312 6846-6858 GO:0035102 denotes PRC1 complex
T20313 6931-6935 PR:000014441 denotes mr-s
T20314 7038-7048 GO:0010467 denotes expression
T20315 7063-7068 SO:0000704 denotes genes
T20316 7076-7083 UBERON:0000966 denotes retinal
T20317 7076-7097 CL:0010009 denotes retinal photoreceptor
T20318 7084-7109 GO:0042461 denotes photoreceptor development
T20319 7166-7170 PR:000014441 denotes mr-s
T20320 7267-7271 PR:000014441 denotes mr-s
T20321 7302-7315 GO:0097617 denotes hybridization
T20322 7340-7344 PR:000014441 denotes mr-s
T20323 7345-7355 GO:0010467 denotes expression
T20324 7375-7382 UBERON:0000966 denotes retinal
T20325 7375-7397 CL:0010009 denotes retinal photoreceptors
T20326 7463-7468 SO:0000704 denotes genes
T20327 7472-7476 PR:000014441 denotes mr-s
T20328 7490-7503 CL:0000210 denotes photoreceptor
T20329 7504-7509 SO:0000704 denotes genes
T20330 7525-7529 PR:000014441 denotes mr-s
T20331 7547-7557 GO:0010467 denotes expression
T20332 7565-7578 CL:0000210 denotes photoreceptor
T20333 7579-7584 SO:0000704 denotes genes
T20334 7588-7591 _FRAGMENT denotes rod
T20335 7601-7615 CL:0000604 denotes photoreceptors
T20336 7596-7615 CL:0000573 denotes cone photoreceptors
T20337 7655-7659 PR:000014441 denotes mr-s
T20338 7675-7701 _FRAGMENT denotes cell fate determination of
T20339 7706-7720 GO:0043703 denotes photoreceptors
T20340 7728-7747 GO:0042671 denotes cone photoreceptors
T20341 7702-7720 CL:0000604 denotes rod photoreceptors
T20342 7728-7747 CL:0000573 denotes cone photoreceptors
T20343 7755-7774 CL:0000573 denotes cone photoreceptors
T20344 7795-7810 UBERON:0019248 denotes early embryonic
T20345 7821-7826 NCBITaxon:10088 denotes mouse
T20346 7827-7840 GO:0060041 denotes retinogenesis
T20347 7842-7860 CL:0000604 denotes rod photoreceptors
T20348 7887-7901 _FRAGMENT denotes late embryonic
T20349 7922-7928 UBERON:0007220 denotes period
T20350 7916-7921 GO:0007567 denotes natal
T20351 7939-7949 GO:0010467 denotes expression
T20352 7961-7965 PR:000014441 denotes mr-s
T20353 7983-7987 PR:000014441 denotes mr-s
T20354 7991-8000 GO:0010467 denotes expressed
T20355 8004-8022 CL:0000604 denotes rod photoreceptors
T20356 8034-8053 CL:0000573 denotes cone photoreceptors
T20357 8065-8070 PR:000011403 denotes Nr2e3
T20358 8150-8168 CL:0000573 denotes cone photoreceptor
T20359 8178-8183 SO:0000704 denotes genes
T20360 8223-8227 PR:000014441 denotes mr-s
T20361 8241-8245 NCBITaxon:10088 denotes mice
T20362 8275-8279 PR:000014441 denotes mr-s
R4870 T20349 T20348 _lexicallyChainedTo period,late embryonic
R4867 T20335 T20334 _lexicallyChainedTo photoreceptors,rod
R4868 T20339 T20338 _lexicallyChainedTo photoreceptors,cell fate determination of
R4869 T20340 T20338 _lexicallyChainedTo cone photoreceptors,cell fate determination of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T20693 11-13 IN denotes In
T20694 36-46 VBD denotes identified
T20695 14-17 DT denotes the
T20696 26-31 NN denotes study
T20697 18-25 JJ denotes present
T20698 31-33 , denotes ,
T20699 33-35 PRP denotes we
T20700 47-48 DT denotes a
T20701 55-59 NN denotes gene
T20702 49-54 JJ denotes novel
T20703 59-61 , denotes ,
T20704 61-63 NN denotes mr
T20705 64-65 NN denotes s
T20706 63-64 HYPH denotes -
T20707 65-67 , denotes ,
T20708 67-72 WDT denotes which
T20709 90-99 VBN denotes expressed
T20710 73-75 VBZ denotes is
T20711 76-89 RB denotes predominantly
T20712 100-102 IN denotes in
T20713 103-110 JJ denotes retinal
T20714 111-125 NNS denotes photoreceptors
T20715 126-129 CC denotes and
T20716 130-133 DT denotes the
T20717 141-146 NN denotes gland
T20718 134-140 JJ denotes pineal
T20719 146-147 . denotes .
T20720 147-214 sentence denotes The peak of mr-s expression in the developing retina is around P6.
T20721 148-151 DT denotes The
T20722 152-156 NN denotes peak
T20723 201-203 VBZ denotes is
T20724 157-159 IN denotes of
T20725 160-162 NN denotes mr
T20726 163-164 NN denotes s
T20727 162-163 HYPH denotes -
T20728 165-175 NN denotes expression
T20729 176-178 IN denotes in
T20730 179-182 DT denotes the
T20731 194-200 NN denotes retina
T20732 183-193 VBG denotes developing
T20733 204-210 IN denotes around
T20734 211-213 NN denotes P6
T20735 213-214 . denotes .
T20736 214-335 sentence denotes This expression pattern correlates with the rapid increase of Crx, rhodopsin and other photoreceptor genes around P6-P8.
T20737 215-219 DT denotes This
T20738 231-238 NN denotes pattern
T20739 220-230 NN denotes expression
T20740 239-249 VBZ denotes correlates
T20741 250-254 IN denotes with
T20742 255-258 DT denotes the
T20743 265-273 NN denotes increase
T20744 259-264 JJ denotes rapid
T20745 274-276 IN denotes of
T20746 277-280 NN denotes Crx
T20747 280-282 , denotes ,
T20748 282-291 NN denotes rhodopsin
T20749 292-295 CC denotes and
T20750 296-301 JJ denotes other
T20751 316-321 NNS denotes genes
T20752 302-315 NN denotes photoreceptor
T20753 322-328 IN denotes around
T20754 329-331 NN denotes P6
T20755 331-332 SYM denotes -
T20756 332-334 NN denotes P8
T20757 334-335 . denotes .
T20758 335-458 sentence denotes Around P6, the outer plexiform layer becomes visible and the outer layer of retina separates into two layers, ONL and INL.
T20759 336-342 IN denotes Around
T20760 373-380 VBZ denotes becomes
T20761 343-345 NN denotes P6
T20762 345-347 , denotes ,
T20763 347-350 DT denotes the
T20764 367-372 NN denotes layer
T20765 351-356 JJ denotes outer
T20766 357-366 NN denotes plexiform
T20767 381-388 JJ denotes visible
T20768 389-392 CC denotes and
T20769 393-396 DT denotes the
T20770 403-408 NN denotes layer
T20771 397-402 JJ denotes outer
T20772 419-428 VBZ denotes separates
T20773 409-411 IN denotes of
T20774 412-418 NN denotes retina
T20775 429-433 IN denotes into
T20776 434-437 CD denotes two
T20777 438-444 NNS denotes layers
T20778 444-446 , denotes ,
T20779 446-449 NN denotes ONL
T20780 450-453 CC denotes and
T20781 454-457 NN denotes INL
T20782 457-458 . denotes .
T20783 458-561 sentence denotes At the same time, photoreceptors begin to undergo terminal differentiation, forming the outer segment.
T20784 459-461 IN denotes At
T20785 492-497 VBP denotes begin
T20786 462-465 DT denotes the
T20787 471-475 NN denotes time
T20788 466-470 JJ denotes same
T20789 475-477 , denotes ,
T20790 477-491 NNS denotes photoreceptors
T20791 498-500 TO denotes to
T20792 501-508 VB denotes undergo
T20793 509-517 JJ denotes terminal
T20794 518-533 NN denotes differentiation
T20795 533-535 , denotes ,
T20796 535-542 VBG denotes forming
T20797 543-546 DT denotes the
T20798 553-560 NN denotes segment
T20799 547-552 JJ denotes outer
T20800 560-561 . denotes .
T20801 561-658 sentence denotes We therefore hypothesized that mr-s is a key molecule in the late development of photoreceptors.
T20802 562-564 PRP denotes We
T20803 575-587 VBD denotes hypothesized
T20804 565-574 RB denotes therefore
T20805 588-592 IN denotes that
T20806 598-600 VBZ denotes is
T20807 593-595 NN denotes mr
T20808 596-597 NN denotes s
T20809 595-596 HYPH denotes -
T20810 601-602 DT denotes a
T20811 607-615 NN denotes molecule
T20812 603-606 JJ denotes key
T20813 616-618 IN denotes in
T20814 619-622 DT denotes the
T20815 628-639 NN denotes development
T20816 623-627 JJ denotes late
T20817 640-642 IN denotes of
T20818 643-657 NNS denotes photoreceptors
T20819 657-658 . denotes .
T20820 658-807 sentence denotes We previously reported that Otx2 and Crx have a critical role in photoreceptor development and that Otx2 directly regulates Crx transcription [3,9].
T20821 659-661 PRP denotes We
T20822 673-681 VBD denotes reported
T20823 662-672 RB denotes previously
T20824 682-686 IN denotes that
T20825 700-704 VBP denotes have
T20826 687-691 NN denotes Otx2
T20827 692-695 CC denotes and
T20828 696-699 NN denotes Crx
T20829 705-706 DT denotes a
T20830 716-720 NN denotes role
T20831 707-715 JJ denotes critical
T20832 721-723 IN denotes in
T20833 724-737 NN denotes photoreceptor
T20834 738-749 NN denotes development
T20835 750-753 CC denotes and
T20836 754-758 IN denotes that
T20837 773-782 VBZ denotes regulates
T20838 759-763 NN denotes Otx2
T20839 764-772 RB denotes directly
T20840 783-786 NN denotes Crx
T20841 787-800 NN denotes transcription
T20842 801-802 -LRB- denotes [
T20843 804-805 CD denotes 9
T20844 802-803 CD denotes 3
T20845 803-804 , denotes ,
T20846 805-806 -RRB- denotes ]
T20847 806-807 . denotes .
T20848 807-923 sentence denotes In situ hybridization and RT-PCR showed significant reduction of mr-s signal in the Crx KO retina and pineal gland.
T20849 808-810 FW denotes In
T20850 811-815 FW denotes situ
T20851 816-829 NN denotes hybridization
T20852 841-847 VBD denotes showed
T20853 830-833 CC denotes and
T20854 834-836 NN denotes RT
T20855 837-840 NN denotes PCR
T20856 836-837 HYPH denotes -
T20857 848-859 JJ denotes significant
T20858 860-869 NN denotes reduction
T20859 870-872 IN denotes of
T20860 873-875 NN denotes mr
T20861 876-877 NN denotes s
T20862 875-876 HYPH denotes -
T20863 878-884 NN denotes signal
T20864 885-887 IN denotes in
T20865 888-891 DT denotes the
T20866 896-898 NN denotes KO
T20867 892-895 NN denotes Crx
T20868 899-905 NN denotes retina
T20869 906-909 CC denotes and
T20870 910-916 JJ denotes pineal
T20871 917-922 NN denotes gland
T20872 922-923 . denotes .
T20873 923-1058 sentence denotes Furthermore, the luciferase assay demonstrated that Otx2 and Crx may directly upregulate the transcription of mr-s in mammalian cells.
T20874 924-935 RB denotes Furthermore
T20875 958-970 VBD denotes demonstrated
T20876 935-937 , denotes ,
T20877 937-940 DT denotes the
T20878 952-957 NN denotes assay
T20879 941-951 NN denotes luciferase
T20880 971-975 IN denotes that
T20881 1002-1012 VB denotes upregulate
T20882 976-980 NN denotes Otx2
T20883 981-984 CC denotes and
T20884 985-988 NN denotes Crx
T20885 989-992 MD denotes may
T20886 993-1001 RB denotes directly
T20887 1013-1016 DT denotes the
T20888 1017-1030 NN denotes transcription
T20889 1031-1033 IN denotes of
T20890 1034-1036 NN denotes mr
T20891 1037-1038 NN denotes s
T20892 1036-1037 HYPH denotes -
T20893 1039-1041 IN denotes in
T20894 1042-1051 JJ denotes mammalian
T20895 1052-1057 NNS denotes cells
T20896 1057-1058 . denotes .
T20897 1058-1205 sentence denotes In retinal photoreceptor cells, the Otx2 transcripts are not highly expressed at P6-P9, while the Crx transcripts are strongly detected around P6.
T20898 1059-1061 IN denotes In
T20899 1112-1115 VBP denotes are
T20900 1062-1069 JJ denotes retinal
T20901 1084-1089 NNS denotes cells
T20902 1070-1083 NN denotes photoreceptor
T20903 1089-1091 , denotes ,
T20904 1091-1094 DT denotes the
T20905 1100-1111 NNS denotes transcripts
T20906 1095-1099 NN denotes Otx2
T20907 1116-1119 RB denotes not
T20908 1120-1126 RB denotes highly
T20909 1127-1136 JJ denotes expressed
T20910 1137-1139 IN denotes at
T20911 1140-1142 NN denotes P6
T20912 1142-1143 SYM denotes -
T20913 1143-1145 NN denotes P9
T20914 1145-1147 , denotes ,
T20915 1147-1152 IN denotes while
T20916 1186-1194 VBN denotes detected
T20917 1153-1156 DT denotes the
T20918 1161-1172 NNS denotes transcripts
T20919 1157-1160 NN denotes Crx
T20920 1173-1176 VBP denotes are
T20921 1177-1185 RB denotes strongly
T20922 1195-1201 IN denotes around
T20923 1202-1204 NN denotes P6
T20924 1204-1205 . denotes .
T20925 1205-1299 sentence denotes Therefore, our results strongly suggest that mr-s transcription is directly regulated by Crx.
T20926 1206-1215 RB denotes Therefore
T20927 1238-1245 VBP denotes suggest
T20928 1215-1217 , denotes ,
T20929 1217-1220 PRP$ denotes our
T20930 1221-1228 NNS denotes results
T20931 1229-1237 RB denotes strongly
T20932 1246-1250 IN denotes that
T20933 1282-1291 VBN denotes regulated
T20934 1251-1253 NN denotes mr
T20935 1254-1255 NN denotes s
T20936 1253-1254 HYPH denotes -
T20937 1256-1269 NN denotes transcription
T20938 1270-1272 VBZ denotes is
T20939 1273-1281 RB denotes directly
T20940 1292-1294 IN denotes by
T20941 1295-1298 NN denotes Crx
T20942 1298-1299 . denotes .
T20943 1299-1481 sentence denotes In the present study, Nrl, a photoreceptor-specific transcription factor that is highly expressed in photoreceptors at the postnatal stage, did not affect the transcription of mr-s.
T20944 1300-1302 IN denotes In
T20945 1448-1454 VB denotes affect
T20946 1303-1306 DT denotes the
T20947 1315-1320 NN denotes study
T20948 1307-1314 JJ denotes present
T20949 1320-1322 , denotes ,
T20950 1322-1325 NN denotes Nrl
T20951 1325-1327 , denotes ,
T20952 1327-1328 DT denotes a
T20953 1366-1372 NN denotes factor
T20954 1329-1342 NN denotes photoreceptor
T20955 1343-1351 JJ denotes specific
T20956 1342-1343 HYPH denotes -
T20957 1352-1365 NN denotes transcription
T20958 1373-1377 WDT denotes that
T20959 1388-1397 VBN denotes expressed
T20960 1378-1380 VBZ denotes is
T20961 1381-1387 RB denotes highly
T20962 1398-1400 IN denotes in
T20963 1401-1415 NNS denotes photoreceptors
T20964 1416-1418 IN denotes at
T20965 1419-1422 DT denotes the
T20966 1433-1438 NN denotes stage
T20967 1423-1432 JJ denotes postnatal
T20968 1438-1440 , denotes ,
T20969 1440-1443 VBD denotes did
T20970 1444-1447 RB denotes not
T20971 1455-1458 DT denotes the
T20972 1459-1472 NN denotes transcription
T20973 1473-1475 IN denotes of
T20974 1476-1478 NN denotes mr
T20975 1479-1480 NN denotes s
T20976 1478-1479 HYPH denotes -
T20977 1480-1481 . denotes .
T20978 1481-1589 sentence denotes This finding is actually consistent with the analysis of the Nrl KO mouse which was recently reported [40].
T20979 1482-1486 DT denotes This
T20980 1487-1494 NN denotes finding
T20981 1495-1497 VBZ denotes is
T20982 1498-1506 RB denotes actually
T20983 1507-1517 JJ denotes consistent
T20984 1518-1522 IN denotes with
T20985 1523-1526 DT denotes the
T20986 1527-1535 NN denotes analysis
T20987 1536-1538 IN denotes of
T20988 1539-1542 DT denotes the
T20989 1550-1555 NN denotes mouse
T20990 1543-1546 NN denotes Nrl
T20991 1547-1549 NN denotes KO
T20992 1556-1561 WDT denotes which
T20993 1575-1583 VBN denotes reported
T20994 1562-1565 VBD denotes was
T20995 1566-1574 RB denotes recently
T20996 1584-1585 -LRB- denotes [
T20997 1585-1587 CD denotes 40
T20998 1587-1588 -RRB- denotes ]
T20999 1588-1589 . denotes .
T21000 1589-1769 sentence denotes The expression profiles of wild-type and Nrl KO retinas at P2, P10 and 2 months were analyzed and mr-s was not included in 161 differentially expressed genes in the Nrl KO retina.
T21001 1590-1593 DT denotes The
T21002 1605-1613 NNS denotes profiles
T21003 1594-1604 NN denotes expression
T21004 1675-1683 VBN denotes analyzed
T21005 1614-1616 IN denotes of
T21006 1617-1621 JJ denotes wild
T21007 1622-1626 NN denotes type
T21008 1621-1622 HYPH denotes -
T21009 1638-1645 NNS denotes retinas
T21010 1627-1630 CC denotes and
T21011 1631-1634 NN denotes Nrl
T21012 1635-1637 NN denotes KO
T21013 1646-1648 IN denotes at
T21014 1649-1651 NN denotes P2
T21015 1651-1653 , denotes ,
T21016 1653-1656 NN denotes P10
T21017 1657-1660 CC denotes and
T21018 1661-1662 CD denotes 2
T21019 1663-1669 NNS denotes months
T21020 1670-1674 VBD denotes were
T21021 1684-1687 CC denotes and
T21022 1688-1690 NN denotes mr
T21023 1691-1692 NN denotes s
T21024 1690-1691 HYPH denotes -
T21025 1701-1709 VBN denotes included
T21026 1693-1696 VBD denotes was
T21027 1697-1700 RB denotes not
T21028 1710-1712 IN denotes in
T21029 1713-1716 CD denotes 161
T21030 1742-1747 NNS denotes genes
T21031 1717-1731 RB denotes differentially
T21032 1732-1741 VBN denotes expressed
T21033 1748-1750 IN denotes in
T21034 1751-1754 DT denotes the
T21035 1762-1768 NN denotes retina
T21036 1755-1758 NN denotes Nrl
T21037 1759-1761 NN denotes KO
T21038 1768-1769 . denotes .
T21039 1769-1857 sentence denotes Previous reports suggested that the SAM domain is a protein-protein interaction module.
T21040 1770-1778 JJ denotes Previous
T21041 1779-1786 NNS denotes reports
T21042 1787-1796 VBD denotes suggested
T21043 1797-1801 IN denotes that
T21044 1817-1819 VBZ denotes is
T21045 1802-1805 DT denotes the
T21046 1810-1816 NN denotes domain
T21047 1806-1809 NN denotes SAM
T21048 1820-1821 DT denotes a
T21049 1850-1856 NN denotes module
T21050 1822-1829 NN denotes protein
T21051 1830-1837 NN denotes protein
T21052 1829-1830 HYPH denotes -
T21053 1838-1849 NN denotes interaction
T21054 1856-1857 . denotes .
T21055 1857-2070 sentence denotes The SAM domain of the mr-s protein is closely related to that of ph and TEL, whose SAM domains can form a helical, head-to-tail polymeric structure and mediate the formation of a higher order chromatin structure.
T21056 1858-1861 DT denotes The
T21057 1866-1872 NN denotes domain
T21058 1862-1865 NN denotes SAM
T21059 1904-1911 VBN denotes related
T21060 1873-1875 IN denotes of
T21061 1876-1879 DT denotes the
T21062 1885-1892 NN denotes protein
T21063 1880-1882 NN denotes mr
T21064 1883-1884 NN denotes s
T21065 1882-1883 HYPH denotes -
T21066 1893-1895 VBZ denotes is
T21067 1896-1903 RB denotes closely
T21068 1912-1914 IN denotes to
T21069 1915-1919 DT denotes that
T21070 1920-1922 IN denotes of
T21071 1923-1925 NN denotes ph
T21072 1926-1929 CC denotes and
T21073 1930-1933 NN denotes TEL
T21074 1933-1935 , denotes ,
T21075 1935-1940 WP$ denotes whose
T21076 1945-1952 NNS denotes domains
T21077 1941-1944 NN denotes SAM
T21078 1957-1961 VB denotes form
T21079 1953-1956 MD denotes can
T21080 1962-1963 DT denotes a
T21081 1996-2005 NN denotes structure
T21082 1964-1971 JJ denotes helical
T21083 1971-1973 , denotes ,
T21084 1973-1977 NN denotes head
T21085 1977-1978 HYPH denotes -
T21086 1978-1980 IN denotes to
T21087 1980-1981 HYPH denotes -
T21088 1981-1985 NN denotes tail
T21089 1986-1995 JJ denotes polymeric
T21090 2006-2009 CC denotes and
T21091 2010-2017 VB denotes mediate
T21092 2018-2021 DT denotes the
T21093 2022-2031 NN denotes formation
T21094 2032-2034 IN denotes of
T21095 2035-2036 DT denotes a
T21096 2060-2069 NN denotes structure
T21097 2037-2043 JJR denotes higher
T21098 2044-2049 NN denotes order
T21099 2050-2059 NN denotes chromatin
T21100 2069-2070 . denotes .
T21101 2070-2196 sentence denotes To characterize the biochemical function of mr-s, we performed yeast two-hybrid screening using full-length mr-s as the bait.
T21102 2071-2073 TO denotes To
T21103 2074-2086 VB denotes characterize
T21104 2124-2133 VBD denotes performed
T21105 2087-2090 DT denotes the
T21106 2103-2111 NN denotes function
T21107 2091-2102 JJ denotes biochemical
T21108 2112-2114 IN denotes of
T21109 2115-2117 NN denotes mr
T21110 2118-2119 NN denotes s
T21111 2117-2118 HYPH denotes -
T21112 2119-2121 , denotes ,
T21113 2121-2123 PRP denotes we
T21114 2134-2139 NN denotes yeast
T21115 2151-2160 NN denotes screening
T21116 2140-2143 CD denotes two
T21117 2144-2150 NN denotes hybrid
T21118 2143-2144 HYPH denotes -
T21119 2161-2166 VBG denotes using
T21120 2167-2171 JJ denotes full
T21121 2172-2178 NN denotes length
T21122 2171-2172 HYPH denotes -
T21123 2182-2183 NN denotes s
T21124 2179-2181 NN denotes mr
T21125 2181-2182 HYPH denotes -
T21126 2184-2186 IN denotes as
T21127 2187-2190 DT denotes the
T21128 2191-2195 NN denotes bait
T21129 2195-2196 . denotes .
T21130 2196-2326 sentence denotes As a result, the most frequent positive clones (5/28) in the screening were the cDNA fragments containing the SAM domain of mr-s.
T21131 2197-2199 IN denotes As
T21132 2268-2272 VBD denotes were
T21133 2200-2201 DT denotes a
T21134 2202-2208 NN denotes result
T21135 2208-2210 , denotes ,
T21136 2210-2213 DT denotes the
T21137 2237-2243 NNS denotes clones
T21138 2214-2218 RBS denotes most
T21139 2219-2227 JJ denotes frequent
T21140 2228-2236 JJ denotes positive
T21141 2244-2245 -LRB- denotes (
T21142 2245-2246 CD denotes 5
T21143 2246-2247 SYM denotes /
T21144 2247-2249 CD denotes 28
T21145 2249-2250 -RRB- denotes )
T21146 2251-2253 IN denotes in
T21147 2254-2257 DT denotes the
T21148 2258-2267 NN denotes screening
T21149 2273-2276 DT denotes the
T21150 2282-2291 NNS denotes fragments
T21151 2277-2281 NN denotes cDNA
T21152 2292-2302 VBG denotes containing
T21153 2303-2306 DT denotes the
T21154 2311-2317 NN denotes domain
T21155 2307-2310 NN denotes SAM
T21156 2318-2320 IN denotes of
T21157 2321-2323 NN denotes mr
T21158 2324-2325 NN denotes s
T21159 2323-2324 HYPH denotes -
T21160 2325-2326 . denotes .
T21161 2326-2399 sentence denotes This strongly suggests that mr-s self-associates through its SAM domain.
T21162 2327-2331 DT denotes This
T21163 2341-2349 VBZ denotes suggests
T21164 2332-2340 RB denotes strongly
T21165 2350-2354 IN denotes that
T21166 2365-2375 VBZ denotes associates
T21167 2355-2357 NN denotes mr
T21168 2358-2359 NN denotes s
T21169 2357-2358 HYPH denotes -
T21170 2360-2364 NN denotes self
T21171 2364-2365 HYPH denotes -
T21172 2376-2383 IN denotes through
T21173 2384-2387 PRP$ denotes its
T21174 2392-2398 NN denotes domain
T21175 2388-2391 NN denotes SAM
T21176 2398-2399 . denotes .
T21177 2399-2585 sentence denotes An immunoprecipitation assay, using two site-directed mutants of the SAM domain of mr-s, demonstrated that the mr-s protein can self-associate through its SAM domain in mammalian cells.
T21178 2400-2402 DT denotes An
T21179 2423-2428 NN denotes assay
T21180 2403-2422 NN denotes immunoprecipitation
T21181 2489-2501 VBD denotes demonstrated
T21182 2428-2430 , denotes ,
T21183 2430-2435 VBG denotes using
T21184 2436-2439 CD denotes two
T21185 2454-2461 NNS denotes mutants
T21186 2440-2444 NN denotes site
T21187 2445-2453 VBN denotes directed
T21188 2444-2445 HYPH denotes -
T21189 2462-2464 IN denotes of
T21190 2465-2468 DT denotes the
T21191 2473-2479 NN denotes domain
T21192 2469-2472 NN denotes SAM
T21193 2480-2482 IN denotes of
T21194 2483-2485 NN denotes mr
T21195 2486-2487 NN denotes s
T21196 2485-2486 HYPH denotes -
T21197 2487-2489 , denotes ,
T21198 2502-2506 IN denotes that
T21199 2533-2542 VB denotes associate
T21200 2507-2510 DT denotes the
T21201 2516-2523 NN denotes protein
T21202 2511-2513 NN denotes mr
T21203 2514-2515 NN denotes s
T21204 2513-2514 HYPH denotes -
T21205 2524-2527 MD denotes can
T21206 2528-2532 NN denotes self
T21207 2532-2533 HYPH denotes -
T21208 2543-2550 IN denotes through
T21209 2551-2554 PRP$ denotes its
T21210 2559-2565 NN denotes domain
T21211 2555-2558 NN denotes SAM
T21212 2566-2568 IN denotes in
T21213 2569-2578 JJ denotes mammalian
T21214 2579-2584 NNS denotes cells
T21215 2584-2585 . denotes .
T21216 2585-2950 sentence denotes While we did not address the question whether the SAM domain of mr-s forms a polymeric structure in the present study, the phylogenetic analysis of SAM domain of mr-s and other SAM domain-containing molecules suggests that mr-s can form head-to-tail polymer and mediate gene silencing by spreading repressive complexes along the chromatin similar to ph and/or TEL.
T21217 2586-2591 IN denotes While
T21218 2603-2610 VB denotes address
T21219 2592-2594 PRP denotes we
T21220 2595-2598 VBD denotes did
T21221 2599-2602 RB denotes not
T21222 2795-2803 VBZ denotes suggests
T21223 2611-2614 DT denotes the
T21224 2615-2623 NN denotes question
T21225 2624-2631 IN denotes whether
T21226 2655-2660 VBZ denotes forms
T21227 2632-2635 DT denotes the
T21228 2640-2646 NN denotes domain
T21229 2636-2639 NN denotes SAM
T21230 2647-2649 IN denotes of
T21231 2650-2652 NN denotes mr
T21232 2653-2654 NN denotes s
T21233 2652-2653 HYPH denotes -
T21234 2661-2662 DT denotes a
T21235 2673-2682 NN denotes structure
T21236 2663-2672 JJ denotes polymeric
T21237 2683-2685 IN denotes in
T21238 2686-2689 DT denotes the
T21239 2698-2703 NN denotes study
T21240 2690-2697 JJ denotes present
T21241 2703-2705 , denotes ,
T21242 2705-2708 DT denotes the
T21243 2722-2730 NN denotes analysis
T21244 2709-2721 JJ denotes phylogenetic
T21245 2731-2733 IN denotes of
T21246 2734-2737 NN denotes SAM
T21247 2738-2744 NN denotes domain
T21248 2745-2747 IN denotes of
T21249 2748-2750 NN denotes mr
T21250 2751-2752 NN denotes s
T21251 2750-2751 HYPH denotes -
T21252 2753-2756 CC denotes and
T21253 2757-2762 JJ denotes other
T21254 2785-2794 NNS denotes molecules
T21255 2763-2766 NN denotes SAM
T21256 2767-2773 NN denotes domain
T21257 2774-2784 VBG denotes containing
T21258 2773-2774 HYPH denotes -
T21259 2804-2808 IN denotes that
T21260 2818-2822 VB denotes form
T21261 2809-2811 NN denotes mr
T21262 2812-2813 NN denotes s
T21263 2811-2812 HYPH denotes -
T21264 2814-2817 MD denotes can
T21265 2823-2827 NN denotes head
T21266 2836-2843 NN denotes polymer
T21267 2827-2828 HYPH denotes -
T21268 2828-2830 IN denotes to
T21269 2830-2831 HYPH denotes -
T21270 2831-2835 NN denotes tail
T21271 2844-2847 CC denotes and
T21272 2848-2855 VBP denotes mediate
T21273 2856-2860 NN denotes gene
T21274 2861-2870 NN denotes silencing
T21275 2871-2873 IN denotes by
T21276 2874-2883 VBG denotes spreading
T21277 2884-2894 JJ denotes repressive
T21278 2895-2904 NNS denotes complexes
T21279 2905-2910 IN denotes along
T21280 2911-2914 DT denotes the
T21281 2915-2924 NN denotes chromatin
T21282 2925-2932 JJ denotes similar
T21283 2933-2935 IN denotes to
T21284 2936-2938 NN denotes ph
T21285 2939-2942 CC denotes and
T21286 2942-2943 HYPH denotes /
T21287 2943-2945 CC denotes or
T21288 2946-2949 NN denotes TEL
T21289 2949-2950 . denotes .
T21290 2950-3163 sentence denotes Although our results in the immunoprecipitation assay demonstrated that the N-terminal constructs lacking a SAM domain still interact with each other, these results do not fit into the head-to-tail polymer model.
T21291 2951-2959 IN denotes Although
T21292 3005-3017 VBD denotes demonstrated
T21293 2960-2963 PRP$ denotes our
T21294 2964-2971 NNS denotes results
T21295 2972-2974 IN denotes in
T21296 2975-2978 DT denotes the
T21297 2999-3004 NN denotes assay
T21298 2979-2998 NN denotes immunoprecipitation
T21299 3123-3126 VB denotes fit
T21300 3018-3022 IN denotes that
T21301 3076-3084 VBP denotes interact
T21302 3023-3026 DT denotes the
T21303 3038-3048 NNS denotes constructs
T21304 3027-3028 NN denotes N
T21305 3029-3037 JJ denotes terminal
T21306 3028-3029 HYPH denotes -
T21307 3049-3056 VBG denotes lacking
T21308 3057-3058 DT denotes a
T21309 3063-3069 NN denotes domain
T21310 3059-3062 NN denotes SAM
T21311 3070-3075 RB denotes still
T21312 3085-3089 IN denotes with
T21313 3090-3094 DT denotes each
T21314 3095-3100 JJ denotes other
T21315 3100-3102 , denotes ,
T21316 3102-3107 DT denotes these
T21317 3108-3115 NNS denotes results
T21318 3116-3118 VBP denotes do
T21319 3119-3122 RB denotes not
T21320 3127-3131 IN denotes into
T21321 3132-3135 DT denotes the
T21322 3157-3162 NN denotes model
T21323 3136-3140 NN denotes head
T21324 3140-3141 HYPH denotes -
T21325 3141-3143 IN denotes to
T21326 3143-3144 HYPH denotes -
T21327 3144-3148 NN denotes tail
T21328 3149-3156 NN denotes polymer
T21329 3162-3163 . denotes .
T21330 3163-3301 sentence denotes We cannot exclude the possibility that the resulting protein-protein interaction of mr-s is an artifact of the overexpression conditions.
T21331 3164-3166 PRP denotes We
T21332 3174-3181 VB denotes exclude
T21333 3167-3170 MD denotes can
T21334 3170-3173 RB denotes not
T21335 3182-3185 DT denotes the
T21336 3186-3197 NN denotes possibility
T21337 3198-3202 IN denotes that
T21338 3253-3255 VBZ denotes is
T21339 3203-3206 DT denotes the
T21340 3233-3244 NN denotes interaction
T21341 3207-3216 VBG denotes resulting
T21342 3217-3224 NN denotes protein
T21343 3225-3232 NN denotes protein
T21344 3224-3225 HYPH denotes -
T21345 3245-3247 IN denotes of
T21346 3248-3250 NN denotes mr
T21347 3251-3252 NN denotes s
T21348 3250-3251 HYPH denotes -
T21349 3256-3258 DT denotes an
T21350 3259-3267 NN denotes artifact
T21351 3268-3270 IN denotes of
T21352 3271-3274 DT denotes the
T21353 3290-3300 NNS denotes conditions
T21354 3275-3289 NN denotes overexpression
T21355 3300-3301 . denotes .
T21356 3301-3374 sentence denotes The issue of whether or not mr-s forms a polymer awaits future analysis.
T21357 3302-3305 DT denotes The
T21358 3306-3311 NN denotes issue
T21359 3351-3357 VBZ denotes awaits
T21360 3312-3314 IN denotes of
T21361 3315-3322 IN denotes whether
T21362 3335-3340 VBZ denotes forms
T21363 3323-3325 CC denotes or
T21364 3326-3329 RB denotes not
T21365 3330-3332 NN denotes mr
T21366 3333-3334 NN denotes s
T21367 3332-3333 HYPH denotes -
T21368 3341-3342 DT denotes a
T21369 3343-3350 NN denotes polymer
T21370 3358-3364 JJ denotes future
T21371 3365-3373 NN denotes analysis
T21372 3373-3374 . denotes .
T21373 3374-3536 sentence denotes A previous report indicated that TEL contains a sequence-specific DNA binding domain, namely the ETS domain, and binds to specific sites via its ETS domain [41].
T21374 3375-3376 DT denotes A
T21375 3386-3392 NN denotes report
T21376 3377-3385 JJ denotes previous
T21377 3393-3402 VBD denotes indicated
T21378 3403-3407 IN denotes that
T21379 3412-3420 VBZ denotes contains
T21380 3408-3411 NN denotes TEL
T21381 3421-3422 DT denotes a
T21382 3453-3459 NN denotes domain
T21383 3423-3431 NN denotes sequence
T21384 3432-3440 JJ denotes specific
T21385 3431-3432 HYPH denotes -
T21386 3441-3444 NN denotes DNA
T21387 3445-3452 VBG denotes binding
T21388 3459-3461 , denotes ,
T21389 3476-3482 NN denotes domain
T21390 3461-3467 RB denotes namely
T21391 3468-3471 DT denotes the
T21392 3472-3475 NN denotes ETS
T21393 3482-3484 , denotes ,
T21394 3484-3487 CC denotes and
T21395 3488-3493 VBZ denotes binds
T21396 3494-3496 IN denotes to
T21397 3497-3505 JJ denotes specific
T21398 3506-3511 NNS denotes sites
T21399 3512-3515 IN denotes via
T21400 3516-3519 PRP$ denotes its
T21401 3524-3530 NN denotes domain
T21402 3520-3523 NN denotes ETS
T21403 3531-3532 -LRB- denotes [
T21404 3532-3534 CD denotes 41
T21405 3534-3535 -RRB- denotes ]
T21406 3535-3536 . denotes .
T21407 3536-3632 sentence denotes TEL could serve to nucleate a polymer, which would spread by oligomerization of the SAM domain.
T21408 3537-3540 NN denotes TEL
T21409 3547-3552 VB denotes serve
T21410 3541-3546 MD denotes could
T21411 3553-3555 TO denotes to
T21412 3556-3564 VB denotes nucleate
T21413 3565-3566 DT denotes a
T21414 3567-3574 NN denotes polymer
T21415 3574-3576 , denotes ,
T21416 3576-3581 WDT denotes which
T21417 3588-3594 VB denotes spread
T21418 3582-3587 MD denotes would
T21419 3595-3597 IN denotes by
T21420 3598-3613 NN denotes oligomerization
T21421 3614-3616 IN denotes of
T21422 3617-3620 DT denotes the
T21423 3625-3631 NN denotes domain
T21424 3621-3624 NN denotes SAM
T21425 3631-3632 . denotes .
T21426 3632-3725 sentence denotes In contrast to TEL, ph does not contain an obvious sequence-specific DNA binding motif (16).
T21427 3633-3635 IN denotes In
T21428 3665-3672 VB denotes contain
T21429 3636-3644 NN denotes contrast
T21430 3645-3647 IN denotes to
T21431 3648-3651 NN denotes TEL
T21432 3651-3653 , denotes ,
T21433 3653-3655 NN denotes ph
T21434 3656-3660 VBZ denotes does
T21435 3661-3664 RB denotes not
T21436 3673-3675 DT denotes an
T21437 3714-3719 NN denotes motif
T21438 3676-3683 JJ denotes obvious
T21439 3684-3692 NN denotes sequence
T21440 3693-3701 JJ denotes specific
T21441 3692-3693 HYPH denotes -
T21442 3702-3705 NN denotes DNA
T21443 3706-3713 VBG denotes binding
T21444 3720-3721 -LRB- denotes (
T21445 3721-3723 CD denotes 16
T21446 3723-3724 -RRB- denotes )
T21447 3724-3725 . denotes .
T21448 3725-3870 sentence denotes Therefore, its initial binding to the template may require protein-protein interactions with other sequence-specific transcriptional repressors.
T21449 3726-3735 RB denotes Therefore
T21450 3777-3784 VB denotes require
T21451 3735-3737 , denotes ,
T21452 3737-3740 PRP$ denotes its
T21453 3749-3756 NN denotes binding
T21454 3741-3748 JJ denotes initial
T21455 3757-3759 IN denotes to
T21456 3760-3763 DT denotes the
T21457 3764-3772 NN denotes template
T21458 3773-3776 MD denotes may
T21459 3785-3792 NN denotes protein
T21460 3793-3800 NN denotes protein
T21461 3792-3793 HYPH denotes -
T21462 3801-3813 NNS denotes interactions
T21463 3814-3818 IN denotes with
T21464 3819-3824 JJ denotes other
T21465 3859-3869 NNS denotes repressors
T21466 3825-3833 NN denotes sequence
T21467 3834-3842 JJ denotes specific
T21468 3833-3834 HYPH denotes -
T21469 3843-3858 JJ denotes transcriptional
T21470 3869-3870 . denotes .
T21471 3870-4069 sentence denotes The segmentation gene-encoding transcriptional repressors such as Hunchback have a role in recruiting SAM domain-containing PcG proteins, which can spread along the template via polymerization [42].
T21472 3871-3874 DT denotes The
T21473 3918-3928 NNS denotes repressors
T21474 3875-3887 NN denotes segmentation
T21475 3888-3892 NN denotes gene
T21476 3893-3901 VBG denotes encoding
T21477 3892-3893 HYPH denotes -
T21478 3902-3917 JJ denotes transcriptional
T21479 3947-3951 VBP denotes have
T21480 3929-3933 JJ denotes such
T21481 3934-3936 IN denotes as
T21482 3937-3946 NN denotes Hunchback
T21483 3952-3953 DT denotes a
T21484 3954-3958 NN denotes role
T21485 3959-3961 IN denotes in
T21486 3962-3972 VBG denotes recruiting
T21487 3973-3976 NN denotes SAM
T21488 3999-4007 NN denotes proteins
T21489 3977-3983 NN denotes domain
T21490 3984-3994 VBG denotes containing
T21491 3983-3984 HYPH denotes -
T21492 3995-3998 NN denotes PcG
T21493 4007-4009 , denotes ,
T21494 4009-4014 WDT denotes which
T21495 4019-4025 VB denotes spread
T21496 4015-4018 MD denotes can
T21497 4026-4031 IN denotes along
T21498 4032-4035 DT denotes the
T21499 4036-4044 NN denotes template
T21500 4045-4048 IN denotes via
T21501 4049-4063 NN denotes polymerization
T21502 4064-4065 -LRB- denotes [
T21503 4065-4067 CD denotes 42
T21504 4067-4068 -RRB- denotes ]
T21505 4068-4069 . denotes .
T21506 4069-4221 sentence denotes Since mr-s does not contain obvious DNA binding motifs, we suppose that there is a sequence-specific transcription factor(s) which interacts with mr-s.
T21507 4070-4075 IN denotes Since
T21508 4090-4097 VB denotes contain
T21509 4076-4078 NN denotes mr
T21510 4079-4080 NN denotes s
T21511 4078-4079 HYPH denotes -
T21512 4081-4085 VBZ denotes does
T21513 4086-4089 RB denotes not
T21514 4129-4136 VBP denotes suppose
T21515 4098-4105 JJ denotes obvious
T21516 4118-4124 NNS denotes motifs
T21517 4106-4109 NN denotes DNA
T21518 4110-4117 VBG denotes binding
T21519 4124-4126 , denotes ,
T21520 4126-4128 PRP denotes we
T21521 4137-4141 IN denotes that
T21522 4148-4150 VBZ denotes is
T21523 4142-4147 EX denotes there
T21524 4151-4152 DT denotes a
T21525 4185-4191 NN denotes factor
T21526 4153-4161 NN denotes sequence
T21527 4162-4170 JJ denotes specific
T21528 4161-4162 HYPH denotes -
T21529 4171-4184 NN denotes transcription
T21530 4191-4192 -LRB- denotes (
T21531 4192-4193 AFX denotes s
T21532 4193-4194 -RRB- denotes )
T21533 4195-4200 WDT denotes which
T21534 4201-4210 VBZ denotes interacts
T21535 4211-4215 IN denotes with
T21536 4216-4218 NN denotes mr
T21537 4219-4220 NN denotes s
T21538 4218-4219 HYPH denotes -
T21539 4220-4221 . denotes .
T21540 4221-4315 sentence denotes However, we did not find any transcription factors in the present yeast two-hybrid screening.
T21541 4222-4229 RB denotes However
T21542 4242-4246 VB denotes find
T21543 4229-4231 , denotes ,
T21544 4231-4233 PRP denotes we
T21545 4234-4237 VBD denotes did
T21546 4238-4241 RB denotes not
T21547 4247-4250 DT denotes any
T21548 4265-4272 NNS denotes factors
T21549 4251-4264 NN denotes transcription
T21550 4273-4275 IN denotes in
T21551 4276-4279 DT denotes the
T21552 4305-4314 NN denotes screening
T21553 4280-4287 JJ denotes present
T21554 4288-4293 NN denotes yeast
T21555 4294-4297 CD denotes two
T21556 4298-4304 NN denotes hybrid
T21557 4297-4298 HYPH denotes -
T21558 4314-4315 . denotes .
T21559 4315-4440 sentence denotes We also found that full-length mr-s fused to the GAL4 DNA binding domain (DBD-mrs) functions as a transcriptional repressor.
T21560 4316-4318 PRP denotes We
T21561 4324-4329 VBD denotes found
T21562 4319-4323 RB denotes also
T21563 4330-4334 IN denotes that
T21564 4399-4408 VBZ denotes functions
T21565 4335-4339 JJ denotes full
T21566 4340-4346 NN denotes length
T21567 4339-4340 HYPH denotes -
T21568 4350-4351 NN denotes s
T21569 4347-4349 NN denotes mr
T21570 4349-4350 HYPH denotes -
T21571 4352-4357 VBN denotes fused
T21572 4358-4360 IN denotes to
T21573 4361-4364 DT denotes the
T21574 4382-4388 NN denotes domain
T21575 4365-4369 NN denotes GAL4
T21576 4370-4373 NN denotes DNA
T21577 4374-4381 VBG denotes binding
T21578 4389-4390 -LRB- denotes (
T21579 4394-4397 NN denotes mrs
T21580 4390-4393 NN denotes DBD
T21581 4393-4394 HYPH denotes -
T21582 4397-4398 -RRB- denotes )
T21583 4409-4411 IN denotes as
T21584 4412-4413 DT denotes a
T21585 4430-4439 NN denotes repressor
T21586 4414-4429 JJ denotes transcriptional
T21587 4439-4440 . denotes .
T21588 4440-4561 sentence denotes This may support the idea that mr-s is involved in repressive complexes similar to other SAM domain-containing proteins.
T21589 4441-4445 DT denotes This
T21590 4450-4457 VB denotes support
T21591 4446-4449 MD denotes may
T21592 4458-4461 DT denotes the
T21593 4462-4466 NN denotes idea
T21594 4467-4471 IN denotes that
T21595 4480-4488 VBN denotes involved
T21596 4472-4474 NN denotes mr
T21597 4475-4476 NN denotes s
T21598 4474-4475 HYPH denotes -
T21599 4477-4479 VBZ denotes is
T21600 4489-4491 IN denotes in
T21601 4492-4502 JJ denotes repressive
T21602 4503-4512 NNS denotes complexes
T21603 4513-4520 JJ denotes similar
T21604 4521-4523 IN denotes to
T21605 4524-4529 JJ denotes other
T21606 4552-4560 NN denotes proteins
T21607 4530-4533 NN denotes SAM
T21608 4534-4540 NN denotes domain
T21609 4541-4551 VBG denotes containing
T21610 4540-4541 HYPH denotes -
T21611 4560-4561 . denotes .
T21612 4561-4709 sentence denotes Our results, however, showed that the self-association of mr-s through its SAM domain is not essential for the transcriptional repressive activity.
T21613 4562-4565 PRP$ denotes Our
T21614 4566-4573 NNS denotes results
T21615 4584-4590 VBD denotes showed
T21616 4573-4575 , denotes ,
T21617 4575-4582 RB denotes however
T21618 4582-4584 , denotes ,
T21619 4591-4595 IN denotes that
T21620 4648-4650 VBZ denotes is
T21621 4596-4599 DT denotes the
T21622 4605-4616 NN denotes association
T21623 4600-4604 NN denotes self
T21624 4604-4605 HYPH denotes -
T21625 4617-4619 IN denotes of
T21626 4620-4622 NN denotes mr
T21627 4623-4624 NN denotes s
T21628 4622-4623 HYPH denotes -
T21629 4625-4632 IN denotes through
T21630 4633-4636 PRP$ denotes its
T21631 4641-4647 NN denotes domain
T21632 4637-4640 NN denotes SAM
T21633 4651-4654 RB denotes not
T21634 4655-4664 JJ denotes essential
T21635 4665-4668 IN denotes for
T21636 4669-4672 DT denotes the
T21637 4700-4708 NN denotes activity
T21638 4673-4688 JJ denotes transcriptional
T21639 4689-4699 JJ denotes repressive
T21640 4708-4709 . denotes .
T21641 4709-4839 sentence denotes Polymerization of the SAM domain has been previously reported to be essential for the repressive functions of ph and TEL [43,44].
T21642 4710-4724 NN denotes Polymerization
T21643 4763-4771 VBN denotes reported
T21644 4725-4727 IN denotes of
T21645 4728-4731 DT denotes the
T21646 4736-4742 NN denotes domain
T21647 4732-4735 NN denotes SAM
T21648 4743-4746 VBZ denotes has
T21649 4747-4751 VBN denotes been
T21650 4752-4762 RB denotes previously
T21651 4772-4774 TO denotes to
T21652 4775-4777 VB denotes be
T21653 4778-4787 JJ denotes essential
T21654 4788-4791 IN denotes for
T21655 4792-4795 DT denotes the
T21656 4807-4816 NNS denotes functions
T21657 4796-4806 JJ denotes repressive
T21658 4817-4819 IN denotes of
T21659 4820-4822 NN denotes ph
T21660 4823-4826 CC denotes and
T21661 4827-4830 NN denotes TEL
T21662 4831-4832 -LRB- denotes [
T21663 4835-4837 CD denotes 44
T21664 4832-4834 CD denotes 43
T21665 4834-4835 , denotes ,
T21666 4837-4838 -RRB- denotes ]
T21667 4838-4839 . denotes .
T21668 4839-5130 sentence denotes On the other hand, human lethal(3) malignant brain tumor (H-L(3)MBT) protein, which also contains a SAM domain at the C-terminus, was reported as a transcriptional repressor and the repressor activity of H-L(3)MBT required mainly the presence of the MBT repeats but not the SAM domain [45].
T21669 4840-4842 IN denotes On
T21670 4974-4982 VBN denotes reported
T21671 4843-4846 DT denotes the
T21672 4853-4857 NN denotes hand
T21673 4847-4852 JJ denotes other
T21674 4857-4859 , denotes ,
T21675 4859-4864 JJ denotes human
T21676 4909-4916 NN denotes protein
T21677 4865-4871 JJ denotes lethal
T21678 4871-4872 -LRB- denotes (
T21679 4872-4873 CD denotes 3
T21680 4873-4874 -RRB- denotes )
T21681 4875-4884 JJ denotes malignant
T21682 4891-4896 NN denotes tumor
T21683 4885-4890 NN denotes brain
T21684 4897-4898 -LRB- denotes (
T21685 4902-4903 CD denotes 3
T21686 4898-4899 NN denotes H
T21687 4899-4900 SYM denotes -
T21688 4900-4901 NN denotes L
T21689 4901-4902 -LRB- denotes (
T21690 4903-4904 -RRB- denotes )
T21691 4904-4907 NN denotes MBT
T21692 4907-4908 -RRB- denotes )
T21693 4916-4918 , denotes ,
T21694 4918-4923 WDT denotes which
T21695 4929-4937 VBZ denotes contains
T21696 4924-4928 RB denotes also
T21697 4938-4939 DT denotes a
T21698 4944-4950 NN denotes domain
T21699 4940-4943 NN denotes SAM
T21700 4951-4953 IN denotes at
T21701 4954-4957 DT denotes the
T21702 4960-4968 NN denotes terminus
T21703 4958-4959 NN denotes C
T21704 4959-4960 HYPH denotes -
T21705 4968-4970 , denotes ,
T21706 4970-4973 VBD denotes was
T21707 4983-4985 IN denotes as
T21708 4986-4987 DT denotes a
T21709 5004-5013 NN denotes repressor
T21710 4988-5003 JJ denotes transcriptional
T21711 5014-5017 CC denotes and
T21712 5018-5021 DT denotes the
T21713 5032-5040 NN denotes activity
T21714 5022-5031 NN denotes repressor
T21715 5054-5062 VBD denotes required
T21716 5041-5043 IN denotes of
T21717 5044-5045 NN denotes H
T21718 5050-5053 NN denotes MBT
T21719 5045-5046 SYM denotes -
T21720 5046-5047 NN denotes L
T21721 5047-5048 -LRB- denotes (
T21722 5048-5049 CD denotes 3
T21723 5049-5050 -RRB- denotes )
T21724 5063-5069 RB denotes mainly
T21725 5070-5073 DT denotes the
T21726 5074-5082 NN denotes presence
T21727 5083-5085 IN denotes of
T21728 5086-5089 DT denotes the
T21729 5094-5101 NNS denotes repeats
T21730 5090-5093 NN denotes MBT
T21731 5102-5105 CC denotes but
T21732 5106-5109 RB denotes not
T21733 5110-5113 DT denotes the
T21734 5118-5124 NN denotes domain
T21735 5114-5117 NN denotes SAM
T21736 5125-5126 -LRB- denotes [
T21737 5126-5128 CD denotes 45
T21738 5128-5129 -RRB- denotes ]
T21739 5129-5130 . denotes .
T21740 5130-5288 sentence denotes To determine the transcriptional repressor region of the mr-s protein, we performed a luciferase assay using site-directed mutants (DBD-W404A and DBD-G453A).
T21741 5131-5133 TO denotes To
T21742 5134-5143 VB denotes determine
T21743 5205-5214 VBD denotes performed
T21744 5144-5147 DT denotes the
T21745 5174-5180 NN denotes region
T21746 5148-5163 JJ denotes transcriptional
T21747 5164-5173 NN denotes repressor
T21748 5181-5183 IN denotes of
T21749 5184-5187 DT denotes the
T21750 5193-5200 NN denotes protein
T21751 5188-5190 NN denotes mr
T21752 5191-5192 NN denotes s
T21753 5190-5191 HYPH denotes -
T21754 5200-5202 , denotes ,
T21755 5202-5204 PRP denotes we
T21756 5215-5216 DT denotes a
T21757 5228-5233 NN denotes assay
T21758 5217-5227 NN denotes luciferase
T21759 5234-5239 VBG denotes using
T21760 5240-5244 NN denotes site
T21761 5245-5253 VBN denotes directed
T21762 5244-5245 HYPH denotes -
T21763 5254-5261 NNS denotes mutants
T21764 5262-5263 -LRB- denotes (
T21765 5267-5272 NN denotes W404A
T21766 5263-5266 NN denotes DBD
T21767 5266-5267 HYPH denotes -
T21768 5273-5276 CC denotes and
T21769 5277-5280 NN denotes DBD
T21770 5281-5286 NN denotes G453A
T21771 5280-5281 HYPH denotes -
T21772 5286-5287 -RRB- denotes )
T21773 5287-5288 . denotes .
T21774 5288-5440 sentence denotes The result showed that the reduced binding ability of self-association partially compromises the transcriptional repressive activity of mr-s (Fig. 7D).
T21775 5289-5292 DT denotes The
T21776 5293-5299 NN denotes result
T21777 5300-5306 VBD denotes showed
T21778 5307-5311 IN denotes that
T21779 5370-5381 VBZ denotes compromises
T21780 5312-5315 DT denotes the
T21781 5332-5339 NN denotes ability
T21782 5316-5323 VBN denotes reduced
T21783 5324-5331 NN denotes binding
T21784 5340-5342 IN denotes of
T21785 5343-5347 NN denotes self
T21786 5348-5359 NN denotes association
T21787 5347-5348 HYPH denotes -
T21788 5360-5369 RB denotes partially
T21789 5382-5385 DT denotes the
T21790 5413-5421 NN denotes activity
T21791 5386-5401 JJ denotes transcriptional
T21792 5402-5412 JJ denotes repressive
T21793 5422-5424 IN denotes of
T21794 5425-5427 NN denotes mr
T21795 5428-5429 NN denotes s
T21796 5427-5428 HYPH denotes -
T21797 5430-5431 -LRB- denotes (
T21798 5436-5438 NN denotes 7D
T21799 5431-5435 NN denotes Fig.
T21800 5438-5439 -RRB- denotes )
T21801 5439-5440 . denotes .
T21802 5440-5599 sentence denotes However, the repressive effect was more significant when DBD-tail, which does not contain SAM domain, was co-introduced with the 5xGAL4-pGL3 reporter plasmid.
T21803 5441-5448 RB denotes However
T21804 5472-5475 VBD denotes was
T21805 5448-5450 , denotes ,
T21806 5450-5453 DT denotes the
T21807 5465-5471 NN denotes effect
T21808 5454-5464 JJ denotes repressive
T21809 5476-5480 RBR denotes more
T21810 5481-5492 JJ denotes significant
T21811 5493-5497 WRB denotes when
T21812 5547-5560 VBN denotes co-introduced
T21813 5498-5501 NN denotes DBD
T21814 5502-5506 NN denotes tail
T21815 5501-5502 HYPH denotes -
T21816 5506-5508 , denotes ,
T21817 5508-5513 WDT denotes which
T21818 5523-5530 VB denotes contain
T21819 5514-5518 VBZ denotes does
T21820 5519-5522 RB denotes not
T21821 5531-5534 NN denotes SAM
T21822 5535-5541 NN denotes domain
T21823 5541-5543 , denotes ,
T21824 5543-5546 VBD denotes was
T21825 5561-5565 IN denotes with
T21826 5566-5569 DT denotes the
T21827 5591-5598 NN denotes plasmid
T21828 5570-5576 NN denotes 5xGAL4
T21829 5577-5581 NN denotes pGL3
T21830 5576-5577 HYPH denotes -
T21831 5582-5590 NN denotes reporter
T21832 5598-5599 . denotes .
T21833 5599-5734 sentence denotes Therefore, we conclude that a region from amino acids 463 to 542 is mainly responsible for the repressor activity in the case of mr-s.
T21834 5600-5609 RB denotes Therefore
T21835 5614-5622 VBP denotes conclude
T21836 5609-5611 , denotes ,
T21837 5611-5613 PRP denotes we
T21838 5623-5627 IN denotes that
T21839 5665-5667 VBZ denotes is
T21840 5628-5629 DT denotes a
T21841 5630-5636 NN denotes region
T21842 5637-5641 IN denotes from
T21843 5642-5647 NN denotes amino
T21844 5654-5657 CD denotes 463
T21845 5648-5653 NNS denotes acids
T21846 5658-5660 IN denotes to
T21847 5661-5664 CD denotes 542
T21848 5668-5674 RB denotes mainly
T21849 5675-5686 JJ denotes responsible
T21850 5687-5690 IN denotes for
T21851 5691-5694 DT denotes the
T21852 5705-5713 NN denotes activity
T21853 5695-5704 NN denotes repressor
T21854 5714-5716 IN denotes in
T21855 5717-5720 DT denotes the
T21856 5721-5725 NN denotes case
T21857 5726-5728 IN denotes of
T21858 5729-5731 NN denotes mr
T21859 5732-5733 NN denotes s
T21860 5731-5732 HYPH denotes -
T21861 5733-5734 . denotes .
T21862 5734-5883 sentence denotes Evolutionary conservation of the C-terminal 80 aa region of mr-s from zebrafish through human may underlie the functional importance of this region.
T21863 5735-5747 JJ denotes Evolutionary
T21864 5748-5760 NN denotes conservation
T21865 5833-5841 VB denotes underlie
T21866 5761-5763 IN denotes of
T21867 5764-5767 DT denotes the
T21868 5785-5791 NN denotes region
T21869 5768-5769 NN denotes C
T21870 5770-5778 JJ denotes terminal
T21871 5769-5770 HYPH denotes -
T21872 5779-5781 CD denotes 80
T21873 5782-5784 NN denotes aa
T21874 5792-5794 IN denotes of
T21875 5795-5797 NN denotes mr
T21876 5798-5799 NN denotes s
T21877 5797-5798 HYPH denotes -
T21878 5800-5804 IN denotes from
T21879 5805-5814 NN denotes zebrafish
T21880 5815-5822 IN denotes through
T21881 5823-5828 JJ denotes human
T21882 5829-5832 MD denotes may
T21883 5842-5845 DT denotes the
T21884 5857-5867 NN denotes importance
T21885 5846-5856 JJ denotes functional
T21886 5868-5870 IN denotes of
T21887 5871-5875 DT denotes this
T21888 5876-5882 NN denotes region
T21889 5882-5883 . denotes .
T21890 5883-5961 sentence denotes Two distinct multiprotein PcG complexes, PRC1 and PRC2, have been identified.
T21891 5884-5887 CD denotes Two
T21892 5914-5923 NNS denotes complexes
T21893 5888-5896 JJ denotes distinct
T21894 5897-5909 NN denotes multiprotein
T21895 5910-5913 NN denotes PcG
T21896 5950-5960 VBN denotes identified
T21897 5923-5925 , denotes ,
T21898 5925-5929 NN denotes PRC1
T21899 5930-5933 CC denotes and
T21900 5934-5938 NN denotes PRC2
T21901 5938-5940 , denotes ,
T21902 5940-5944 VBP denotes have
T21903 5945-5949 VBN denotes been
T21904 5960-5961 . denotes .
T21905 5961-6160 sentence denotes PRC2 is involved in the initiation of silencing and contains histone deacetylases (HDACs) and histone methyltransferases, which can methylate histone H3 lysine 9 and 27, marks of silenced chromatin.
T21906 5962-5966 NN denotes PRC2
T21907 5970-5978 VBN denotes involved
T21908 5967-5969 VBZ denotes is
T21909 5979-5981 IN denotes in
T21910 5982-5985 DT denotes the
T21911 5986-5996 NN denotes initiation
T21912 5997-5999 IN denotes of
T21913 6000-6009 NN denotes silencing
T21914 6010-6013 CC denotes and
T21915 6014-6022 VBZ denotes contains
T21916 6023-6030 NN denotes histone
T21917 6031-6043 NNS denotes deacetylases
T21918 6044-6045 -LRB- denotes (
T21919 6045-6050 NNS denotes HDACs
T21920 6050-6051 -RRB- denotes )
T21921 6052-6055 CC denotes and
T21922 6056-6063 NN denotes histone
T21923 6064-6082 NNS denotes methyltransferases
T21924 6082-6084 , denotes ,
T21925 6084-6089 WDT denotes which
T21926 6094-6103 VB denotes methylate
T21927 6090-6093 MD denotes can
T21928 6104-6111 NN denotes histone
T21929 6122-6123 CD denotes 9
T21930 6112-6114 NN denotes H3
T21931 6115-6121 NN denotes lysine
T21932 6124-6127 CC denotes and
T21933 6128-6130 CD denotes 27
T21934 6130-6132 , denotes ,
T21935 6132-6137 NNS denotes marks
T21936 6138-6140 IN denotes of
T21937 6141-6149 VBN denotes silenced
T21938 6150-6159 NN denotes chromatin
T21939 6159-6160 . denotes .
T21940 6160-6379 sentence denotes PRC1, including ph, recognizes the histone H3 lysine 27 mark set by PRC2 and maintains a stable state of gene repression in which PRC1 blocks chromatin remodeling by the trithorax group-related SWI-SNF complex [46,47].
T21941 6161-6165 NN denotes PRC1
T21942 6181-6191 VBZ denotes recognizes
T21943 6165-6167 , denotes ,
T21944 6167-6176 VBG denotes including
T21945 6177-6179 NN denotes ph
T21946 6179-6181 , denotes ,
T21947 6192-6195 DT denotes the
T21948 6217-6221 NN denotes mark
T21949 6196-6203 NN denotes histone
T21950 6204-6206 NN denotes H3
T21951 6207-6213 NN denotes lysine
T21952 6214-6216 CD denotes 27
T21953 6222-6225 VBN denotes set
T21954 6226-6228 IN denotes by
T21955 6229-6233 NN denotes PRC2
T21956 6234-6237 CC denotes and
T21957 6238-6247 VBZ denotes maintains
T21958 6248-6249 DT denotes a
T21959 6257-6262 NN denotes state
T21960 6250-6256 JJ denotes stable
T21961 6263-6265 IN denotes of
T21962 6266-6270 NN denotes gene
T21963 6271-6281 NN denotes repression
T21964 6282-6284 IN denotes in
T21965 6296-6302 VBZ denotes blocks
T21966 6285-6290 WDT denotes which
T21967 6291-6295 NN denotes PRC1
T21968 6303-6312 NN denotes chromatin
T21969 6313-6323 NN denotes remodeling
T21970 6324-6326 IN denotes by
T21971 6327-6330 DT denotes the
T21972 6363-6370 NN denotes complex
T21973 6331-6340 NN denotes trithorax
T21974 6341-6346 NN denotes group
T21975 6347-6354 VBN denotes related
T21976 6346-6347 HYPH denotes -
T21977 6355-6358 NN denotes SWI
T21978 6359-6362 NN denotes SNF
T21979 6358-6359 HYPH denotes -
T21980 6371-6372 -LRB- denotes [
T21981 6375-6377 CD denotes 47
T21982 6372-6374 CD denotes 46
T21983 6374-6375 , denotes ,
T21984 6377-6378 -RRB- denotes ]
T21985 6378-6379 . denotes .
T21986 6379-6532 sentence denotes Therefore, the mechanism of repression by PRC2 is thought to be HDAC-dependent while the mechanism of repression by PRC1 appears to be HDAC-independent.
T21987 6380-6389 RB denotes Therefore
T21988 6430-6437 VBN denotes thought
T21989 6389-6391 , denotes ,
T21990 6391-6394 DT denotes the
T21991 6395-6404 NN denotes mechanism
T21992 6405-6407 IN denotes of
T21993 6408-6418 NN denotes repression
T21994 6419-6421 IN denotes by
T21995 6422-6426 NN denotes PRC2
T21996 6427-6429 VBZ denotes is
T21997 6438-6440 TO denotes to
T21998 6441-6443 VB denotes be
T21999 6444-6448 NN denotes HDAC
T22000 6449-6458 JJ denotes dependent
T22001 6448-6449 HYPH denotes -
T22002 6459-6464 IN denotes while
T22003 6501-6508 VBZ denotes appears
T22004 6465-6468 DT denotes the
T22005 6469-6478 NN denotes mechanism
T22006 6479-6481 IN denotes of
T22007 6482-6492 NN denotes repression
T22008 6493-6495 IN denotes by
T22009 6496-6500 NN denotes PRC1
T22010 6509-6511 TO denotes to
T22011 6512-6514 VB denotes be
T22012 6515-6519 NN denotes HDAC
T22013 6520-6531 JJ denotes independent
T22014 6519-6520 HYPH denotes -
T22015 6531-6532 . denotes .
T22016 6532-6728 sentence denotes Our luciferase assay also showed that transcriptional repression of DBD-mrs was not affected by the addition of various concentrations of trichostatin A, a potent HDAC inhibitor (data not shown).
T22017 6533-6536 PRP$ denotes Our
T22018 6548-6553 NN denotes assay
T22019 6537-6547 NN denotes luciferase
T22020 6559-6565 VBD denotes showed
T22021 6554-6558 RB denotes also
T22022 6566-6570 IN denotes that
T22023 6617-6625 VBN denotes affected
T22024 6571-6586 JJ denotes transcriptional
T22025 6587-6597 NN denotes repression
T22026 6598-6600 IN denotes of
T22027 6601-6604 NN denotes DBD
T22028 6605-6608 NN denotes mrs
T22029 6604-6605 HYPH denotes -
T22030 6609-6612 VBD denotes was
T22031 6613-6616 RB denotes not
T22032 6626-6628 IN denotes by
T22033 6629-6632 DT denotes the
T22034 6633-6641 NN denotes addition
T22035 6642-6644 IN denotes of
T22036 6645-6652 JJ denotes various
T22037 6653-6667 NNS denotes concentrations
T22038 6668-6670 IN denotes of
T22039 6671-6683 NN denotes trichostatin
T22040 6684-6685 NN denotes A
T22041 6685-6687 , denotes ,
T22042 6687-6688 DT denotes a
T22043 6701-6710 NN denotes inhibitor
T22044 6689-6695 JJ denotes potent
T22045 6696-6700 NN denotes HDAC
T22046 6711-6712 -LRB- denotes (
T22047 6721-6726 VBN denotes shown
T22048 6712-6716 NNS denotes data
T22049 6717-6720 RB denotes not
T22050 6726-6727 -RRB- denotes )
T22051 6727-6728 . denotes .
T22052 6728-6859 sentence denotes Therefore, we speculate that the mechanism of repression of mr-s may be HDAC-independent and more similar to that of PRC1 complex.
T22053 6729-6738 RB denotes Therefore
T22054 6743-6752 VBP denotes speculate
T22055 6738-6740 , denotes ,
T22056 6740-6742 PRP denotes we
T22057 6753-6757 IN denotes that
T22058 6798-6800 VB denotes be
T22059 6758-6761 DT denotes the
T22060 6762-6771 NN denotes mechanism
T22061 6772-6774 IN denotes of
T22062 6775-6785 NN denotes repression
T22063 6786-6788 IN denotes of
T22064 6789-6791 NN denotes mr
T22065 6792-6793 NN denotes s
T22066 6791-6792 HYPH denotes -
T22067 6794-6797 MD denotes may
T22068 6801-6805 NN denotes HDAC
T22069 6806-6817 JJ denotes independent
T22070 6805-6806 HYPH denotes -
T22071 6818-6821 CC denotes and
T22072 6822-6826 RBR denotes more
T22073 6827-6834 JJ denotes similar
T22074 6835-6837 IN denotes to
T22075 6838-6842 DT denotes that
T22076 6843-6845 IN denotes of
T22077 6846-6850 NN denotes PRC1
T22078 6851-6858 NN denotes complex
T22079 6858-6859 . denotes .
T22080 6859-7110 sentence denotes In the present study, the biochemical experiments demonstrate that the mr-s protein functions as a transcriptional repressor and possibly down-regulates the spatial and temporal expression of the target genes during retinal photoreceptor development.
T22081 6860-6862 IN denotes In
T22082 6910-6921 VBP denotes demonstrate
T22083 6863-6866 DT denotes the
T22084 6875-6880 NN denotes study
T22085 6867-6874 JJ denotes present
T22086 6880-6882 , denotes ,
T22087 6882-6885 DT denotes the
T22088 6898-6909 NNS denotes experiments
T22089 6886-6897 JJ denotes biochemical
T22090 6922-6926 IN denotes that
T22091 6944-6953 VBZ denotes functions
T22092 6927-6930 DT denotes the
T22093 6936-6943 NN denotes protein
T22094 6931-6933 NN denotes mr
T22095 6934-6935 NN denotes s
T22096 6933-6934 HYPH denotes -
T22097 6954-6956 IN denotes as
T22098 6957-6958 DT denotes a
T22099 6975-6984 NN denotes repressor
T22100 6959-6974 JJ denotes transcriptional
T22101 6985-6988 CC denotes and
T22102 6989-6997 RB denotes possibly
T22103 7003-7012 VBZ denotes regulates
T22104 6998-7002 RB denotes down
T22105 7002-7003 HYPH denotes -
T22106 7013-7016 DT denotes the
T22107 7038-7048 NN denotes expression
T22108 7017-7024 JJ denotes spatial
T22109 7025-7028 CC denotes and
T22110 7029-7037 JJ denotes temporal
T22111 7049-7051 IN denotes of
T22112 7052-7055 DT denotes the
T22113 7063-7068 NNS denotes genes
T22114 7056-7062 NN denotes target
T22115 7069-7075 IN denotes during
T22116 7076-7083 JJ denotes retinal
T22117 7098-7109 NN denotes development
T22118 7084-7097 NN denotes photoreceptor
T22119 7109-7110 . denotes .
T22120 7110-7235 sentence denotes Our data also revealed that the repressive activity of mr-s is mainly due to the C-terminal region (amino acids 463 to 542).
T22121 7111-7114 PRP$ denotes Our
T22122 7115-7119 NNS denotes data
T22123 7125-7133 VBD denotes revealed
T22124 7120-7124 RB denotes also
T22125 7134-7138 IN denotes that
T22126 7171-7173 VBZ denotes is
T22127 7139-7142 DT denotes the
T22128 7154-7162 NN denotes activity
T22129 7143-7153 JJ denotes repressive
T22130 7163-7165 IN denotes of
T22131 7166-7168 NN denotes mr
T22132 7169-7170 NN denotes s
T22133 7168-7169 HYPH denotes -
T22134 7174-7180 RB denotes mainly
T22135 7181-7184 IN denotes due
T22136 7185-7187 IN denotes to
T22137 7188-7191 DT denotes the
T22138 7203-7209 NN denotes region
T22139 7192-7193 NN denotes C
T22140 7194-7202 JJ denotes terminal
T22141 7193-7194 HYPH denotes -
T22142 7210-7211 -LRB- denotes (
T22143 7223-7226 CD denotes 463
T22144 7211-7216 NN denotes amino
T22145 7217-7222 NNS denotes acids
T22146 7227-7229 IN denotes to
T22147 7230-7233 CD denotes 542
T22148 7233-7234 -RRB- denotes )
T22149 7234-7235 . denotes .
T22150 7235-7293 sentence denotes However, downstream targets of mr-s still remain unclear.
T22151 7236-7243 RB denotes However
T22152 7278-7284 VBP denotes remain
T22153 7243-7245 , denotes ,
T22154 7245-7255 JJ denotes downstream
T22155 7256-7263 NNS denotes targets
T22156 7264-7266 IN denotes of
T22157 7267-7269 NN denotes mr
T22158 7270-7271 NN denotes s
T22159 7269-7270 HYPH denotes -
T22160 7272-7277 RB denotes still
T22161 7285-7292 JJ denotes unclear
T22162 7292-7293 . denotes .
T22163 7293-7431 sentence denotes In situ hybridization showed that the peak of mr-s expression is around P6, when retinal photoreceptors undergo terminal differentiation.
T22164 7294-7296 FW denotes In
T22165 7297-7301 FW denotes situ
T22166 7302-7315 NN denotes hybridization
T22167 7316-7322 VBD denotes showed
T22168 7323-7327 IN denotes that
T22169 7356-7358 VBZ denotes is
T22170 7328-7331 DT denotes the
T22171 7332-7336 NN denotes peak
T22172 7337-7339 IN denotes of
T22173 7340-7342 NN denotes mr
T22174 7343-7344 NN denotes s
T22175 7342-7343 HYPH denotes -
T22176 7345-7355 NN denotes expression
T22177 7359-7365 RB denotes around
T22178 7366-7368 NN denotes P6
T22179 7368-7370 , denotes ,
T22180 7370-7374 WRB denotes when
T22181 7398-7405 VBP denotes undergo
T22182 7375-7382 JJ denotes retinal
T22183 7383-7397 NNS denotes photoreceptors
T22184 7406-7414 JJ denotes terminal
T22185 7415-7430 NN denotes differentiation
T22186 7430-7431 . denotes .
T22187 7431-7510 sentence denotes We hypothesize that the target genes of mr-s might be non-photoreceptor genes.
T22188 7432-7434 PRP denotes We
T22189 7435-7446 VBP denotes hypothesize
T22190 7447-7451 IN denotes that
T22191 7483-7485 VB denotes be
T22192 7452-7455 DT denotes the
T22193 7463-7468 NNS denotes genes
T22194 7456-7462 NN denotes target
T22195 7469-7471 IN denotes of
T22196 7472-7474 NN denotes mr
T22197 7475-7476 NN denotes s
T22198 7474-7475 HYPH denotes -
T22199 7477-7482 MD denotes might
T22200 7486-7503 JJ denotes non-photoreceptor
T22201 7504-7509 NNS denotes genes
T22202 7509-7510 . denotes .
T22203 7510-7616 sentence denotes In this case, mr-s may suppress the expression of non-photoreceptor genes in rod and cone photoreceptors.
T22204 7511-7513 IN denotes In
T22205 7534-7542 VB denotes suppress
T22206 7514-7518 DT denotes this
T22207 7519-7523 NN denotes case
T22208 7523-7525 , denotes ,
T22209 7525-7527 NN denotes mr
T22210 7528-7529 NN denotes s
T22211 7527-7528 HYPH denotes -
T22212 7530-7533 MD denotes may
T22213 7543-7546 DT denotes the
T22214 7547-7557 NN denotes expression
T22215 7558-7560 IN denotes of
T22216 7561-7578 JJ denotes non-photoreceptor
T22217 7579-7584 NNS denotes genes
T22218 7585-7587 IN denotes in
T22219 7588-7591 NN denotes rod
T22220 7601-7615 NNS denotes photoreceptors
T22221 7592-7595 CC denotes and
T22222 7596-7600 NN denotes cone
T22223 7615-7616 . denotes .
T22224 7616-7748 sentence denotes There may be another possibility that mr-s is involved in cell fate determination of rod photoreceptors versus cone photoreceptors.
T22225 7617-7622 EX denotes There
T22226 7627-7629 VB denotes be
T22227 7623-7626 MD denotes may
T22228 7630-7637 DT denotes another
T22229 7638-7649 NN denotes possibility
T22230 7650-7654 IN denotes that
T22231 7663-7671 VBN denotes involved
T22232 7655-7657 NN denotes mr
T22233 7658-7659 NN denotes s
T22234 7657-7658 HYPH denotes -
T22235 7660-7662 VBZ denotes is
T22236 7672-7674 IN denotes in
T22237 7675-7679 NN denotes cell
T22238 7680-7684 NN denotes fate
T22239 7685-7698 NN denotes determination
T22240 7699-7701 IN denotes of
T22241 7702-7705 NN denotes rod
T22242 7706-7720 NNS denotes photoreceptors
T22243 7721-7727 CC denotes versus
T22244 7728-7732 NN denotes cone
T22245 7733-7747 NNS denotes photoreceptors
T22246 7747-7748 . denotes .
T22247 7748-7934 sentence denotes While cone photoreceptors are born during the early embryonic stages of mouse retinogenesis, rod photoreceptors are born primarily in the late embryonic and early postnatal period [48].
T22248 7749-7754 IN denotes While
T22249 7779-7783 VBN denotes born
T22250 7755-7759 NN denotes cone
T22251 7760-7774 NNS denotes photoreceptors
T22252 7775-7778 VBP denotes are
T22253 7865-7869 VBN denotes born
T22254 7784-7790 IN denotes during
T22255 7791-7794 DT denotes the
T22256 7811-7817 NNS denotes stages
T22257 7795-7800 JJ denotes early
T22258 7801-7810 JJ denotes embryonic
T22259 7818-7820 IN denotes of
T22260 7821-7826 NN denotes mouse
T22261 7827-7840 NN denotes retinogenesis
T22262 7840-7842 , denotes ,
T22263 7842-7845 NN denotes rod
T22264 7846-7860 NNS denotes photoreceptors
T22265 7861-7864 VBP denotes are
T22266 7870-7879 RB denotes primarily
T22267 7880-7882 IN denotes in
T22268 7883-7886 DT denotes the
T22269 7922-7928 NN denotes period
T22270 7887-7891 JJ denotes late
T22271 7892-7901 JJ denotes embryonic
T22272 7902-7905 CC denotes and
T22273 7906-7911 JJ denotes early
T22274 7912-7921 JJ denotes postnatal
T22275 7929-7930 -LRB- denotes [
T22276 7930-7932 CD denotes 48
T22277 7932-7933 -RRB- denotes ]
T22278 7933-7934 . denotes .
T22279 7934-8184 sentence denotes The expression pattern of mr-s may suggest that mr-s is expressed in rod photoreceptors but not in cone photoreceptors as well as Nr2e3, which is known as a transcriptional repressor and is thought to down-regulate cone photoreceptor-specific genes.
T22280 7935-7938 DT denotes The
T22281 7950-7957 NN denotes pattern
T22282 7939-7949 NN denotes expression
T22283 7970-7977 VB denotes suggest
T22284 7958-7960 IN denotes of
T22285 7961-7963 NN denotes mr
T22286 7964-7965 NN denotes s
T22287 7963-7964 HYPH denotes -
T22288 7966-7969 MD denotes may
T22289 7978-7982 IN denotes that
T22290 7991-8000 VBN denotes expressed
T22291 7983-7985 NN denotes mr
T22292 7986-7987 NN denotes s
T22293 7985-7986 HYPH denotes -
T22294 7988-7990 VBZ denotes is
T22295 8001-8003 IN denotes in
T22296 8004-8007 NN denotes rod
T22297 8008-8022 NNS denotes photoreceptors
T22298 8023-8026 CC denotes but
T22299 8027-8030 RB denotes not
T22300 8031-8033 IN denotes in
T22301 8034-8038 NN denotes cone
T22302 8039-8053 NNS denotes photoreceptors
T22303 8054-8056 RB denotes as
T22304 8062-8064 IN denotes as
T22305 8057-8061 RB denotes well
T22306 8065-8070 NN denotes Nr2e3
T22307 8070-8072 , denotes ,
T22308 8072-8077 WDT denotes which
T22309 8081-8086 VBN denotes known
T22310 8078-8080 VBZ denotes is
T22311 8087-8089 IN denotes as
T22312 8090-8091 DT denotes a
T22313 8108-8117 NN denotes repressor
T22314 8092-8107 JJ denotes transcriptional
T22315 8118-8121 CC denotes and
T22316 8122-8124 VBZ denotes is
T22317 8125-8132 VBN denotes thought
T22318 8133-8135 TO denotes to
T22319 8141-8149 VB denotes regulate
T22320 8136-8140 RB denotes down
T22321 8140-8141 HYPH denotes -
T22322 8150-8154 NN denotes cone
T22323 8178-8183 NNS denotes genes
T22324 8155-8168 NN denotes photoreceptor
T22325 8169-8177 JJ denotes specific
T22326 8168-8169 HYPH denotes -
T22327 8183-8184 . denotes .
T22328 8184-8303 sentence denotes To clarify the biological function of mr-s, analysis of mice with targeted disruptions of mr-s will be very important.
T22329 8185-8187 TO denotes To
T22330 8188-8195 VB denotes clarify
T22331 8285-8287 VB denotes be
T22332 8196-8199 DT denotes the
T22333 8211-8219 NN denotes function
T22334 8200-8210 JJ denotes biological
T22335 8220-8222 IN denotes of
T22336 8223-8225 NN denotes mr
T22337 8226-8227 NN denotes s
T22338 8225-8226 HYPH denotes -
T22339 8227-8229 , denotes ,
T22340 8229-8237 NN denotes analysis
T22341 8238-8240 IN denotes of
T22342 8241-8245 NNS denotes mice
T22343 8246-8250 IN denotes with
T22344 8251-8259 VBN denotes targeted
T22345 8260-8271 NNS denotes disruptions
T22346 8272-8274 IN denotes of
T22347 8275-8277 NN denotes mr
T22348 8278-8279 NN denotes s
T22349 8277-8278 HYPH denotes -
T22350 8280-8284 MD denotes will
T22351 8288-8292 RB denotes very
T22352 8293-8302 JJ denotes important
T22353 8302-8303 . denotes .
R4875 T20693 T20694 prep In,identified
R4876 T20695 T20696 det the,study
R4877 T20696 T20693 pobj study,In
R4878 T20697 T20696 amod present,study
R4879 T20698 T20694 punct ", ",identified
R4880 T20699 T20694 nsubj we,identified
R4881 T20700 T20701 det a,gene
R4882 T20701 T20694 dobj gene,identified
R4883 T20702 T20701 amod novel,gene
R4884 T20703 T20701 punct ", ",gene
R4885 T20704 T20705 compound mr,s
R4886 T20705 T20701 appos s,gene
R4887 T20706 T20705 punct -,s
R4888 T20707 T20701 punct ", ",gene
R4889 T20708 T20709 dep which,expressed
R4890 T20709 T20701 relcl expressed,gene
R4891 T20710 T20709 auxpass is,expressed
R4892 T20711 T20709 advmod predominantly,expressed
R4893 T20712 T20709 prep in,expressed
R4894 T20713 T20714 amod retinal,photoreceptors
R4895 T20714 T20712 pobj photoreceptors,in
R4896 T20715 T20714 cc and,photoreceptors
R4897 T20716 T20717 det the,gland
R4898 T20717 T20714 conj gland,photoreceptors
R4899 T20718 T20717 amod pineal,gland
R4900 T20719 T20694 punct .,identified
R4901 T20721 T20722 det The,peak
R4902 T20722 T20723 nsubj peak,is
R4903 T20724 T20722 prep of,peak
R4904 T20725 T20726 compound mr,s
R4905 T20726 T20728 compound s,expression
R4906 T20727 T20726 punct -,s
R4907 T20728 T20724 pobj expression,of
R4908 T20729 T20728 prep in,expression
R4909 T20730 T20731 det the,retina
R4910 T20731 T20729 pobj retina,in
R4911 T20732 T20731 amod developing,retina
R4912 T20733 T20723 prep around,is
R4913 T20734 T20733 pobj P6,around
R4914 T20735 T20723 punct .,is
R4915 T20737 T20738 det This,pattern
R4916 T20738 T20740 nsubj pattern,correlates
R4917 T20739 T20738 compound expression,pattern
R4918 T20741 T20740 prep with,correlates
R4919 T20742 T20743 det the,increase
R4920 T20743 T20741 pobj increase,with
R4921 T20744 T20743 amod rapid,increase
R4922 T20745 T20743 prep of,increase
R4923 T20746 T20745 pobj Crx,of
R4924 T20747 T20746 punct ", ",Crx
R4925 T20748 T20746 conj rhodopsin,Crx
R4926 T20749 T20748 cc and,rhodopsin
R4927 T20750 T20751 amod other,genes
R4928 T20751 T20748 conj genes,rhodopsin
R4929 T20752 T20751 compound photoreceptor,genes
R4930 T20753 T20743 prep around,increase
R4931 T20754 T20753 pobj P6,around
R4932 T20755 T20756 punct -,P8
R4933 T20756 T20754 prep P8,P6
R4934 T20757 T20740 punct .,correlates
R4935 T20759 T20760 prep Around,becomes
R4936 T20761 T20759 pobj P6,Around
R4937 T20762 T20760 punct ", ",becomes
R4938 T20763 T20764 det the,layer
R4939 T20764 T20760 nsubj layer,becomes
R4940 T20765 T20764 amod outer,layer
R4941 T20766 T20764 compound plexiform,layer
R4942 T20767 T20760 acomp visible,becomes
R4943 T20768 T20760 cc and,becomes
R4944 T20769 T20770 det the,layer
R4945 T20770 T20772 nsubj layer,separates
R4946 T20771 T20770 amod outer,layer
R4947 T20772 T20760 conj separates,becomes
R4948 T20773 T20770 prep of,layer
R4949 T20774 T20773 pobj retina,of
R4950 T20775 T20772 prep into,separates
R4951 T20776 T20777 nummod two,layers
R4952 T20777 T20775 pobj layers,into
R4953 T20778 T20777 punct ", ",layers
R4954 T20779 T20777 appos ONL,layers
R4955 T20780 T20779 cc and,ONL
R4956 T20781 T20779 conj INL,ONL
R4957 T20782 T20760 punct .,becomes
R4958 T20784 T20785 prep At,begin
R4959 T20786 T20787 det the,time
R4960 T20787 T20784 pobj time,At
R4961 T20788 T20787 amod same,time
R4962 T20789 T20785 punct ", ",begin
R4963 T20790 T20785 nsubj photoreceptors,begin
R4964 T20791 T20792 aux to,undergo
R4965 T20792 T20785 xcomp undergo,begin
R4966 T20793 T20794 amod terminal,differentiation
R4967 T20794 T20792 dobj differentiation,undergo
R4968 T20795 T20792 punct ", ",undergo
R4969 T20796 T20792 advcl forming,undergo
R4970 T20797 T20798 det the,segment
R4971 T20798 T20796 dobj segment,forming
R4972 T20799 T20798 amod outer,segment
R4973 T20800 T20785 punct .,begin
R4974 T20802 T20803 nsubj We,hypothesized
R4975 T20804 T20803 advmod therefore,hypothesized
R4976 T20805 T20806 mark that,is
R4977 T20806 T20803 ccomp is,hypothesized
R4978 T20807 T20808 compound mr,s
R4979 T20808 T20806 nsubj s,is
R4980 T20809 T20808 punct -,s
R4981 T20810 T20811 det a,molecule
R4982 T20811 T20806 attr molecule,is
R4983 T20812 T20811 amod key,molecule
R4984 T20813 T20811 prep in,molecule
R4985 T20814 T20815 det the,development
R4986 T20815 T20813 pobj development,in
R4987 T20816 T20815 amod late,development
R4988 T20817 T20815 prep of,development
R4989 T20818 T20817 pobj photoreceptors,of
R4990 T20819 T20803 punct .,hypothesized
R4991 T20821 T20822 nsubj We,reported
R4992 T20823 T20822 advmod previously,reported
R4993 T20824 T20825 mark that,have
R4994 T20825 T20822 advcl have,reported
R4995 T20826 T20825 nsubj Otx2,have
R4996 T20827 T20826 cc and,Otx2
R4997 T20828 T20826 conj Crx,Otx2
R4998 T20829 T20830 det a,role
R4999 T20830 T20825 dobj role,have
R5000 T20831 T20830 amod critical,role
R5001 T20832 T20830 prep in,role
R5002 T20833 T20834 compound photoreceptor,development
R5003 T20834 T20832 pobj development,in
R5004 T20835 T20825 cc and,have
R5005 T20836 T20837 mark that,regulates
R5006 T20837 T20825 conj regulates,have
R5007 T20838 T20837 nsubj Otx2,regulates
R5008 T20839 T20837 advmod directly,regulates
R5009 T20840 T20841 compound Crx,transcription
R5010 T20841 T20837 dobj transcription,regulates
R5011 T20842 T20843 punct [,9
R5012 T20843 T20822 parataxis 9,reported
R5013 T20844 T20843 nummod 3,9
R5014 T20845 T20843 punct ",",9
R5015 T20846 T20843 punct ],9
R5016 T20847 T20822 punct .,reported
R5017 T20849 T20850 advmod In,situ
R5018 T20850 T20851 amod situ,hybridization
R5019 T20851 T20852 nsubj hybridization,showed
R5020 T20853 T20851 cc and,hybridization
R5021 T20854 T20855 compound RT,PCR
R5022 T20855 T20851 conj PCR,hybridization
R5023 T20856 T20855 punct -,PCR
R5024 T20857 T20858 amod significant,reduction
R5025 T20858 T20852 dobj reduction,showed
R5026 T20859 T20858 prep of,reduction
R5027 T20860 T20861 compound mr,s
R5028 T20861 T20863 compound s,signal
R5029 T20862 T20861 punct -,s
R5030 T20863 T20859 pobj signal,of
R5031 T20864 T20852 prep in,showed
R5032 T20865 T20866 det the,KO
R5033 T20866 T20864 pobj KO,in
R5034 T20867 T20866 compound Crx,KO
R5035 T20868 T20866 appos retina,KO
R5036 T20869 T20868 cc and,retina
R5037 T20870 T20871 amod pineal,gland
R5038 T20871 T20868 conj gland,retina
R5039 T20872 T20852 punct .,showed
R5040 T20874 T20875 advmod Furthermore,demonstrated
R5041 T20876 T20875 punct ", ",demonstrated
R5042 T20877 T20878 det the,assay
R5043 T20878 T20875 nsubj assay,demonstrated
R5044 T20879 T20878 compound luciferase,assay
R5045 T20880 T20881 mark that,upregulate
R5046 T20881 T20875 ccomp upregulate,demonstrated
R5047 T20882 T20881 nsubj Otx2,upregulate
R5048 T20883 T20882 cc and,Otx2
R5049 T20884 T20882 conj Crx,Otx2
R5050 T20885 T20881 aux may,upregulate
R5051 T20886 T20881 advmod directly,upregulate
R5052 T20887 T20888 det the,transcription
R5053 T20888 T20881 dobj transcription,upregulate
R5054 T20889 T20888 prep of,transcription
R5055 T20890 T20891 compound mr,s
R5056 T20891 T20889 pobj s,of
R5057 T20892 T20891 punct -,s
R5058 T20893 T20881 prep in,upregulate
R5059 T20894 T20895 amod mammalian,cells
R5060 T20895 T20893 pobj cells,in
R5061 T20896 T20875 punct .,demonstrated
R5062 T20898 T20899 prep In,are
R5063 T20900 T20901 amod retinal,cells
R5064 T20901 T20898 pobj cells,In
R5065 T20902 T20901 compound photoreceptor,cells
R5066 T20903 T20899 punct ", ",are
R5067 T20904 T20905 det the,transcripts
R5068 T20905 T20899 nsubj transcripts,are
R5069 T20906 T20905 compound Otx2,transcripts
R5070 T20907 T20899 neg not,are
R5071 T20908 T20909 advmod highly,expressed
R5072 T20909 T20899 acomp expressed,are
R5073 T20910 T20899 prep at,are
R5074 T20911 T20910 pobj P6,at
R5075 T20912 T20913 punct -,P9
R5076 T20913 T20911 prep P9,P6
R5077 T20914 T20899 punct ", ",are
R5078 T20915 T20916 mark while,detected
R5079 T20916 T20899 advcl detected,are
R5080 T20917 T20918 det the,transcripts
R5081 T20918 T20916 nsubjpass transcripts,detected
R5082 T20919 T20918 compound Crx,transcripts
R5083 T20920 T20916 auxpass are,detected
R5084 T20921 T20916 advmod strongly,detected
R5085 T20922 T20916 prep around,detected
R5086 T20923 T20922 pobj P6,around
R5087 T20924 T20899 punct .,are
R5088 T20926 T20927 advmod Therefore,suggest
R5089 T20928 T20927 punct ", ",suggest
R5090 T20929 T20930 poss our,results
R5091 T20930 T20927 nsubj results,suggest
R5092 T20931 T20927 advmod strongly,suggest
R5093 T20932 T20933 mark that,regulated
R5094 T20933 T20927 ccomp regulated,suggest
R5095 T20934 T20935 compound mr,s
R5096 T20935 T20937 compound s,transcription
R5097 T20936 T20935 punct -,s
R5098 T20937 T20933 nsubjpass transcription,regulated
R5099 T20938 T20933 auxpass is,regulated
R5100 T20939 T20933 advmod directly,regulated
R5101 T20940 T20933 agent by,regulated
R5102 T20941 T20940 pobj Crx,by
R5103 T20942 T20927 punct .,suggest
R5104 T20944 T20945 prep In,affect
R5105 T20946 T20947 det the,study
R5106 T20947 T20944 pobj study,In
R5107 T20948 T20947 amod present,study
R5108 T20949 T20945 punct ", ",affect
R5109 T20950 T20945 nsubj Nrl,affect
R5110 T20951 T20950 punct ", ",Nrl
R5111 T20952 T20953 det a,factor
R5112 T20953 T20950 appos factor,Nrl
R5113 T20954 T20955 npadvmod photoreceptor,specific
R5114 T20955 T20953 amod specific,factor
R5115 T20956 T20955 punct -,specific
R5116 T20957 T20953 compound transcription,factor
R5117 T20958 T20959 dep that,expressed
R5118 T20959 T20953 relcl expressed,factor
R5119 T20960 T20959 auxpass is,expressed
R5120 T20961 T20959 advmod highly,expressed
R5121 T20962 T20959 prep in,expressed
R5122 T20963 T20962 pobj photoreceptors,in
R5123 T20964 T20959 prep at,expressed
R5124 T20965 T20966 det the,stage
R5125 T20966 T20964 pobj stage,at
R5126 T20967 T20966 amod postnatal,stage
R5127 T20968 T20945 punct ", ",affect
R5128 T20969 T20945 aux did,affect
R5129 T20970 T20945 neg not,affect
R5130 T20971 T20972 det the,transcription
R5131 T20972 T20945 dobj transcription,affect
R5132 T20973 T20972 prep of,transcription
R5133 T20974 T20975 compound mr,s
R5134 T20975 T20973 pobj s,of
R5135 T20976 T20975 punct -,s
R5136 T20977 T20945 punct .,affect
R5137 T20979 T20980 det This,finding
R5138 T20980 T20981 nsubj finding,is
R5139 T20982 T20981 advmod actually,is
R5140 T20983 T20981 acomp consistent,is
R5141 T20984 T20983 prep with,consistent
R5142 T20985 T20986 det the,analysis
R5143 T20986 T20984 pobj analysis,with
R5144 T20987 T20986 prep of,analysis
R5145 T20988 T20989 det the,mouse
R5146 T20989 T20987 pobj mouse,of
R5147 T20990 T20991 compound Nrl,KO
R5148 T20991 T20989 compound KO,mouse
R5149 T20992 T20993 dep which,reported
R5150 T20993 T20989 relcl reported,mouse
R5151 T20994 T20993 auxpass was,reported
R5152 T20995 T20993 advmod recently,reported
R5153 T20996 T20997 punct [,40
R5154 T20997 T20981 parataxis 40,is
R5155 T20998 T20997 punct ],40
R5156 T20999 T20981 punct .,is
R5157 T21001 T21002 det The,profiles
R5158 T21002 T21004 nsubjpass profiles,analyzed
R5159 T21003 T21002 compound expression,profiles
R5160 T21005 T21002 prep of,profiles
R5161 T21006 T21007 amod wild,type
R5162 T21007 T21009 nmod type,retinas
R5163 T21008 T21007 punct -,type
R5164 T21009 T21005 pobj retinas,of
R5165 T21010 T21007 cc and,type
R5166 T21011 T21012 compound Nrl,KO
R5167 T21012 T21007 conj KO,type
R5168 T21013 T21002 prep at,profiles
R5169 T21014 T21013 pobj P2,at
R5170 T21015 T21014 punct ", ",P2
R5171 T21016 T21014 conj P10,P2
R5172 T21017 T21016 cc and,P10
R5173 T21018 T21019 nummod 2,months
R5174 T21019 T21016 conj months,P10
R5175 T21020 T21004 auxpass were,analyzed
R5176 T21021 T21004 cc and,analyzed
R5177 T21022 T21023 compound mr,s
R5178 T21023 T21025 nsubjpass s,included
R5179 T21024 T21023 punct -,s
R5180 T21025 T21004 conj included,analyzed
R5181 T21026 T21025 auxpass was,included
R5182 T21027 T21025 neg not,included
R5183 T21028 T21025 prep in,included
R5184 T21029 T21030 nummod 161,genes
R5185 T21030 T21028 pobj genes,in
R5186 T21031 T21032 advmod differentially,expressed
R5187 T21032 T21030 amod expressed,genes
R5188 T21033 T21025 prep in,included
R5189 T21034 T21035 det the,retina
R5190 T21035 T21033 pobj retina,in
R5191 T21036 T21037 compound Nrl,KO
R5192 T21037 T21035 compound KO,retina
R5193 T21038 T21025 punct .,included
R5194 T21040 T21041 amod Previous,reports
R5195 T21041 T21042 nsubj reports,suggested
R5196 T21043 T21044 mark that,is
R5197 T21044 T21042 ccomp is,suggested
R5198 T21045 T21046 det the,domain
R5199 T21046 T21044 nsubj domain,is
R5200 T21047 T21046 compound SAM,domain
R5201 T21048 T21049 det a,module
R5202 T21049 T21044 attr module,is
R5203 T21050 T21051 compound protein,protein
R5204 T21051 T21049 compound protein,module
R5205 T21052 T21051 punct -,protein
R5206 T21053 T21049 compound interaction,module
R5207 T21054 T21042 punct .,suggested
R5208 T21056 T21057 det The,domain
R5209 T21057 T21059 nsubjpass domain,related
R5210 T21058 T21057 compound SAM,domain
R5211 T21060 T21057 prep of,domain
R5212 T21061 T21062 det the,protein
R5213 T21062 T21060 pobj protein,of
R5214 T21063 T21064 compound mr,s
R5215 T21064 T21062 compound s,protein
R5216 T21065 T21064 punct -,s
R5217 T21066 T21059 auxpass is,related
R5218 T21067 T21059 advmod closely,related
R5219 T21068 T21059 prep to,related
R5220 T21069 T21068 pobj that,to
R5221 T21070 T21069 prep of,that
R5222 T21071 T21070 pobj ph,of
R5223 T21072 T21071 cc and,ph
R5224 T21073 T21071 conj TEL,ph
R5225 T21074 T21071 punct ", ",ph
R5226 T21075 T21076 poss whose,domains
R5227 T21076 T21078 dep domains,form
R5228 T21077 T21076 compound SAM,domains
R5229 T21078 T21071 relcl form,ph
R5230 T21079 T21078 aux can,form
R5231 T21080 T21081 det a,structure
R5232 T21081 T21078 dobj structure,form
R5233 T21082 T21081 amod helical,structure
R5234 T21083 T21081 punct ", ",structure
R5235 T21084 T21081 nmod head,structure
R5236 T21085 T21084 punct -,head
R5237 T21086 T21084 prep to,head
R5238 T21087 T21086 punct -,to
R5239 T21088 T21086 pobj tail,to
R5240 T21089 T21081 amod polymeric,structure
R5241 T21090 T21078 cc and,form
R5242 T21091 T21078 conj mediate,form
R5243 T21092 T21093 det the,formation
R5244 T21093 T21091 dobj formation,mediate
R5245 T21094 T21093 prep of,formation
R5246 T21095 T21096 det a,structure
R5247 T21096 T21094 pobj structure,of
R5248 T21097 T21098 amod higher,order
R5249 T21098 T21096 compound order,structure
R5250 T21099 T21096 compound chromatin,structure
R5251 T21100 T21059 punct .,related
R5252 T21102 T21103 aux To,characterize
R5253 T21103 T21104 advcl characterize,performed
R5254 T21105 T21106 det the,function
R5255 T21106 T21103 dobj function,characterize
R5256 T21107 T21106 amod biochemical,function
R5257 T21108 T21106 prep of,function
R5258 T21109 T21110 compound mr,s
R5259 T21110 T21108 pobj s,of
R5260 T21111 T21110 punct -,s
R5261 T21112 T21104 punct ", ",performed
R5262 T21113 T21104 nsubj we,performed
R5263 T21114 T21115 nmod yeast,screening
R5264 T21115 T21104 dobj screening,performed
R5265 T21116 T21117 nummod two,hybrid
R5266 T21117 T21115 compound hybrid,screening
R5267 T21118 T21117 punct -,hybrid
R5268 T21119 T21104 advcl using,performed
R5269 T21120 T21121 amod full,length
R5270 T21121 T21123 compound length,s
R5271 T21122 T21121 punct -,length
R5272 T21123 T21119 dobj s,using
R5273 T21124 T21123 compound mr,s
R5274 T21125 T21123 punct -,s
R5275 T21126 T21119 prep as,using
R5276 T21127 T21128 det the,bait
R5277 T21128 T21126 pobj bait,as
R5278 T21129 T21104 punct .,performed
R5279 T21131 T21132 prep As,were
R5280 T21133 T21134 det a,result
R5281 T21134 T21131 pobj result,As
R5282 T21135 T21132 punct ", ",were
R5283 T21136 T21137 det the,clones
R5284 T21137 T21132 nsubj clones,were
R5285 T21138 T21139 advmod most,frequent
R5286 T21139 T21137 amod frequent,clones
R5287 T21140 T21137 amod positive,clones
R5288 T21141 T21142 punct (,5
R5289 T21142 T21137 parataxis 5,clones
R5290 T21143 T21144 punct /,28
R5291 T21144 T21142 prep 28,5
R5292 T21145 T21142 punct ),5
R5293 T21146 T21137 prep in,clones
R5294 T21147 T21148 det the,screening
R5295 T21148 T21146 pobj screening,in
R5296 T21173 T21174 poss its,domain
R5297 T21149 T21150 det the,fragments
R5298 T21174 T21172 pobj domain,through
R5299 T21150 T21132 attr fragments,were
R5300 T21175 T21174 compound SAM,domain
R5301 T21176 T21163 punct .,suggests
R5302 T21151 T21150 compound cDNA,fragments
R5303 T21178 T21179 det An,assay
R5304 T21152 T21150 acl containing,fragments
R5305 T21179 T21181 nsubj assay,demonstrated
R5306 T21180 T21179 compound immunoprecipitation,assay
R5307 T21153 T21154 det the,domain
R5308 T21182 T21179 punct ", ",assay
R5309 T21154 T21152 dobj domain,containing
R5310 T21183 T21179 acl using,assay
R5311 T21184 T21185 nummod two,mutants
R5312 T21185 T21183 dobj mutants,using
R5313 T21155 T21154 compound SAM,domain
R5314 T21186 T21187 npadvmod site,directed
R5315 T21187 T21185 amod directed,mutants
R5316 T21188 T21187 punct -,directed
R5317 T21156 T21154 prep of,domain
R5318 T21189 T21185 prep of,mutants
R5319 T21190 T21191 det the,domain
R5320 T21157 T21158 compound mr,s
R5321 T21191 T21189 pobj domain,of
R5322 T21192 T21191 compound SAM,domain
R5323 T21193 T21191 prep of,domain
R5324 T21158 T21156 pobj s,of
R5325 T21194 T21195 compound mr,s
R5326 T21195 T21193 pobj s,of
R5327 T21159 T21158 punct -,s
R5328 T21196 T21195 punct -,s
R5329 T21160 T21132 punct .,were
R5330 T21162 T21163 nsubj This,suggests
R5331 T21197 T21181 punct ", ",demonstrated
R5332 T21198 T21199 mark that,associate
R5333 T21164 T21163 advmod strongly,suggests
R5334 T21199 T21181 ccomp associate,demonstrated
R5335 T21200 T21201 det the,protein
R5336 T21201 T21199 nsubj protein,associate
R5337 T21202 T21203 compound mr,s
R5338 T21203 T21201 compound s,protein
R5339 T21165 T21166 mark that,associates
R5340 T21204 T21203 punct -,s
R5341 T21166 T21163 ccomp associates,suggests
R5342 T21205 T21199 aux can,associate
R5343 T21206 T21199 dep self,associate
R5344 T21207 T21199 punct -,associate
R5345 T21208 T21199 prep through,associate
R5346 T21209 T21210 poss its,domain
R5347 T21167 T21168 compound mr,s
R5348 T21210 T21208 pobj domain,through
R5349 T21211 T21210 compound SAM,domain
R5350 T21168 T21166 nsubj s,associates
R5351 T21212 T21199 prep in,associate
R5352 T21213 T21214 amod mammalian,cells
R5353 T21214 T21212 pobj cells,in
R5354 T21169 T21168 punct -,s
R5355 T21215 T21181 punct .,demonstrated
R5356 T21170 T21166 dep self,associates
R5357 T21217 T21218 mark While,address
R5358 T21218 T21222 advcl address,suggests
R5359 T21171 T21166 punct -,associates
R5360 T21219 T21218 nsubj we,address
R5361 T21220 T21218 aux did,address
R5362 T21221 T21218 neg not,address
R5363 T21172 T21166 prep through,associates
R5364 T21223 T21224 det the,question
R5365 T21224 T21218 dobj question,address
R5366 T21279 T21276 prep along,spreading
R5367 T21225 T21226 mark whether,forms
R5368 T21226 T21224 acl forms,question
R5369 T21227 T21228 det the,domain
R5370 T21228 T21226 nsubj domain,forms
R5371 T21280 T21281 det the,chromatin
R5372 T21229 T21228 compound SAM,domain
R5373 T21230 T21228 prep of,domain
R5374 T21281 T21279 pobj chromatin,along
R5375 T21231 T21232 compound mr,s
R5376 T21232 T21230 pobj s,of
R5377 T21233 T21232 punct -,s
R5378 T21282 T21272 advcl similar,mediate
R5379 T21234 T21235 det a,structure
R5380 T21235 T21226 dobj structure,forms
R5381 T21283 T21282 prep to,similar
R5382 T21236 T21235 amod polymeric,structure
R5383 T21237 T21218 prep in,address
R5384 T21238 T21239 det the,study
R5385 T21284 T21283 pobj ph,to
R5386 T21239 T21237 pobj study,in
R5387 T21240 T21239 amod present,study
R5388 T21241 T21222 punct ", ",suggests
R5389 T21242 T21243 det the,analysis
R5390 T21243 T21222 nsubj analysis,suggests
R5391 T21244 T21243 amod phylogenetic,analysis
R5392 T21285 T21284 cc and,ph
R5393 T21245 T21243 prep of,analysis
R5394 T21286 T21285 punct /,and
R5395 T21246 T21247 compound SAM,domain
R5396 T21247 T21245 pobj domain,of
R5397 T21248 T21247 prep of,domain
R5398 T21249 T21250 compound mr,s
R5399 T21287 T21285 cc or,and
R5400 T21250 T21248 pobj s,of
R5401 T21251 T21250 punct -,s
R5402 T21252 T21250 cc and,s
R5403 T21288 T21284 conj TEL,ph
R5404 T21253 T21254 amod other,molecules
R5405 T21254 T21250 conj molecules,s
R5406 T21289 T21222 punct .,suggests
R5407 T21255 T21256 compound SAM,domain
R5408 T21256 T21257 npadvmod domain,containing
R5409 T21257 T21254 amod containing,molecules
R5410 T21291 T21292 mark Although,demonstrated
R5411 T21258 T21257 punct -,containing
R5412 T21259 T21260 mark that,form
R5413 T21260 T21222 ccomp form,suggests
R5414 T21261 T21262 compound mr,s
R5415 T21292 T21299 advcl demonstrated,fit
R5416 T21262 T21260 nsubj s,form
R5417 T21263 T21262 punct -,s
R5418 T21293 T21294 poss our,results
R5419 T21264 T21260 aux can,form
R5420 T21265 T21266 nmod head,polymer
R5421 T21266 T21260 dobj polymer,form
R5422 T21294 T21292 nsubj results,demonstrated
R5423 T21267 T21265 punct -,head
R5424 T21268 T21265 prep to,head
R5425 T21295 T21294 prep in,results
R5426 T21269 T21268 punct -,to
R5427 T21270 T21268 pobj tail,to
R5428 T21271 T21260 cc and,form
R5429 T21296 T21297 det the,assay
R5430 T21272 T21260 conj mediate,form
R5431 T21273 T21274 compound gene,silencing
R5432 T21274 T21272 dobj silencing,mediate
R5433 T21297 T21295 pobj assay,in
R5434 T21275 T21272 prep by,mediate
R5435 T21276 T21275 pcomp spreading,by
R5436 T21298 T21297 compound immunoprecipitation,assay
R5437 T21277 T21278 amod repressive,complexes
R5438 T21278 T21276 dobj complexes,spreading
R5439 T21300 T21301 mark that,interact
R5440 T21301 T21292 ccomp interact,demonstrated
R5441 T21385 T21384 punct -,specific
R5442 T21302 T21303 det the,constructs
R5443 T21386 T21387 npadvmod DNA,binding
R5444 T21387 T21382 amod binding,domain
R5445 T21303 T21301 nsubj constructs,interact
R5446 T21388 T21389 punct ", ",domain
R5447 T21389 T21382 appos domain,domain
R5448 T21304 T21305 npadvmod N,terminal
R5449 T21390 T21389 advmod namely,domain
R5450 T21391 T21389 det the,domain
R5451 T21305 T21303 amod terminal,constructs
R5452 T21392 T21389 compound ETS,domain
R5453 T21393 T21379 punct ", ",contains
R5454 T21394 T21379 cc and,contains
R5455 T21306 T21305 punct -,terminal
R5456 T21395 T21379 conj binds,contains
R5457 T21396 T21395 prep to,binds
R5458 T21307 T21303 acl lacking,constructs
R5459 T21397 T21398 amod specific,sites
R5460 T21398 T21396 pobj sites,to
R5461 T21399 T21395 prep via,binds
R5462 T21308 T21309 det a,domain
R5463 T21400 T21401 poss its,domain
R5464 T21401 T21399 pobj domain,via
R5465 T21402 T21401 compound ETS,domain
R5466 T21309 T21307 dobj domain,lacking
R5467 T21403 T21404 punct [,41
R5468 T21404 T21377 parataxis 41,indicated
R5469 T21310 T21309 compound SAM,domain
R5470 T21405 T21404 punct ],41
R5471 T21406 T21377 punct .,indicated
R5472 T21311 T21301 advmod still,interact
R5473 T21408 T21409 nsubj TEL,serve
R5474 T21312 T21301 prep with,interact
R5475 T21410 T21409 aux could,serve
R5476 T21411 T21412 aux to,nucleate
R5477 T21412 T21409 xcomp nucleate,serve
R5478 T21313 T21314 det each,other
R5479 T21413 T21414 det a,polymer
R5480 T21414 T21412 dobj polymer,nucleate
R5481 T21314 T21312 pobj other,with
R5482 T21415 T21414 punct ", ",polymer
R5483 T21416 T21417 dep which,spread
R5484 T21417 T21414 relcl spread,polymer
R5485 T21315 T21299 punct ", ",fit
R5486 T21418 T21417 aux would,spread
R5487 T21419 T21417 prep by,spread
R5488 T21420 T21419 pobj oligomerization,by
R5489 T21316 T21317 det these,results
R5490 T21421 T21420 prep of,oligomerization
R5491 T21317 T21299 nsubj results,fit
R5492 T21422 T21423 det the,domain
R5493 T21318 T21299 aux do,fit
R5494 T21423 T21421 pobj domain,of
R5495 T21424 T21423 compound SAM,domain
R5496 T21319 T21299 neg not,fit
R5497 T21425 T21409 punct .,serve
R5498 T21320 T21299 prep into,fit
R5499 T21427 T21428 prep In,contain
R5500 T21429 T21427 pobj contrast,In
R5501 T21321 T21322 det the,model
R5502 T21430 T21429 prep to,contrast
R5503 T21431 T21430 pobj TEL,to
R5504 T21432 T21428 punct ", ",contain
R5505 T21322 T21320 pobj model,into
R5506 T21433 T21428 nsubj ph,contain
R5507 T21434 T21428 aux does,contain
R5508 T21323 T21322 nmod head,model
R5509 T21435 T21428 neg not,contain
R5510 T21436 T21437 det an,motif
R5511 T21437 T21428 dobj motif,contain
R5512 T21324 T21323 punct -,head
R5513 T21438 T21437 amod obvious,motif
R5514 T21439 T21440 npadvmod sequence,specific
R5515 T21440 T21437 amod specific,motif
R5516 T21325 T21323 prep to,head
R5517 T21441 T21440 punct -,specific
R5518 T21442 T21443 npadvmod DNA,binding
R5519 T21443 T21437 amod binding,motif
R5520 T21326 T21325 punct -,to
R5521 T21444 T21445 punct (,16
R5522 T21445 T21428 parataxis 16,contain
R5523 T21446 T21445 punct ),16
R5524 T21327 T21325 pobj tail,to
R5525 T21447 T21428 punct .,contain
R5526 T21449 T21450 advmod Therefore,require
R5527 T21328 T21322 compound polymer,model
R5528 T21451 T21450 punct ", ",require
R5529 T21452 T21453 poss its,binding
R5530 T21329 T21299 punct .,fit
R5531 T21453 T21450 nsubj binding,require
R5532 T21454 T21453 amod initial,binding
R5533 T21331 T21332 nsubj We,exclude
R5534 T21333 T21332 aux can,exclude
R5535 T21455 T21453 prep to,binding
R5536 T21334 T21332 neg not,exclude
R5537 T21456 T21457 det the,template
R5538 T21457 T21455 pobj template,to
R5539 T21458 T21450 aux may,require
R5540 T21335 T21336 det the,possibility
R5541 T21459 T21460 compound protein,protein
R5542 T21460 T21462 compound protein,interactions
R5543 T21461 T21460 punct -,protein
R5544 T21336 T21332 dobj possibility,exclude
R5545 T21462 T21450 dobj interactions,require
R5546 T21463 T21462 prep with,interactions
R5547 T21464 T21465 amod other,repressors
R5548 T21465 T21463 pobj repressors,with
R5549 T21337 T21338 mark that,is
R5550 T21466 T21467 npadvmod sequence,specific
R5551 T21467 T21465 amod specific,repressors
R5552 T21468 T21467 punct -,specific
R5553 T21338 T21336 acl is,possibility
R5554 T21469 T21465 amod transcriptional,repressors
R5555 T21470 T21450 punct .,require
R5556 T21339 T21340 det the,interaction
R5557 T21472 T21473 det The,repressors
R5558 T21473 T21479 nsubj repressors,have
R5559 T21340 T21338 nsubj interaction,is
R5560 T21474 T21473 nmod segmentation,repressors
R5561 T21475 T21476 npadvmod gene,encoding
R5562 T21476 T21473 amod encoding,repressors
R5563 T21341 T21340 amod resulting,interaction
R5564 T21477 T21476 punct -,encoding
R5565 T21478 T21473 amod transcriptional,repressors
R5566 T21342 T21343 compound protein,protein
R5567 T21480 T21481 amod such,as
R5568 T21481 T21473 prep as,repressors
R5569 T21482 T21481 pobj Hunchback,as
R5570 T21343 T21340 compound protein,interaction
R5571 T21483 T21484 det a,role
R5572 T21484 T21479 dobj role,have
R5573 T21344 T21343 punct -,protein
R5574 T21485 T21484 prep in,role
R5575 T21486 T21485 pcomp recruiting,in
R5576 T21487 T21488 nmod SAM,proteins
R5577 T21345 T21340 prep of,interaction
R5578 T21488 T21486 dobj proteins,recruiting
R5579 T21489 T21490 npadvmod domain,containing
R5580 T21346 T21347 compound mr,s
R5581 T21347 T21345 pobj s,of
R5582 T21348 T21347 punct -,s
R5583 T21349 T21350 det an,artifact
R5584 T21350 T21338 attr artifact,is
R5585 T21490 T21488 amod containing,proteins
R5586 T21491 T21490 punct -,containing
R5587 T21492 T21488 compound PcG,proteins
R5588 T21351 T21350 prep of,artifact
R5589 T21493 T21488 punct ", ",proteins
R5590 T21494 T21495 dep which,spread
R5591 T21495 T21488 relcl spread,proteins
R5592 T21352 T21353 det the,conditions
R5593 T21496 T21495 aux can,spread
R5594 T21497 T21495 prep along,spread
R5595 T21498 T21499 det the,template
R5596 T21353 T21351 pobj conditions,of
R5597 T21499 T21497 pobj template,along
R5598 T21500 T21495 prep via,spread
R5599 T21501 T21500 pobj polymerization,via
R5600 T21502 T21503 punct [,42
R5601 T21503 T21479 parataxis 42,have
R5602 T21504 T21503 punct ],42
R5603 T21354 T21353 compound overexpression,conditions
R5604 T21505 T21479 punct .,have
R5605 T21507 T21508 mark Since,contain
R5606 T21355 T21332 punct .,exclude
R5607 T21508 T21514 advcl contain,suppose
R5608 T21509 T21510 compound mr,s
R5609 T21357 T21358 det The,issue
R5610 T21510 T21508 nsubj s,contain
R5611 T21511 T21510 punct -,s
R5612 T21512 T21508 aux does,contain
R5613 T21513 T21508 neg not,contain
R5614 T21358 T21359 nsubj issue,awaits
R5615 T21515 T21516 amod obvious,motifs
R5616 T21516 T21508 dobj motifs,contain
R5617 T21360 T21358 prep of,issue
R5618 T21517 T21518 npadvmod DNA,binding
R5619 T21518 T21516 amod binding,motifs
R5620 T21519 T21514 punct ", ",suppose
R5621 T21361 T21362 mark whether,forms
R5622 T21520 T21514 nsubj we,suppose
R5623 T21521 T21522 mark that,is
R5624 T21522 T21514 ccomp is,suppose
R5625 T21362 T21360 pcomp forms,of
R5626 T21523 T21522 expl there,is
R5627 T21524 T21525 det a,factor
R5628 T21525 T21522 attr factor,is
R5629 T21363 T21362 cc or,forms
R5630 T21526 T21527 npadvmod sequence,specific
R5631 T21527 T21525 amod specific,factor
R5632 T21528 T21527 punct -,specific
R5633 T21364 T21362 neg not,forms
R5634 T21529 T21525 compound transcription,factor
R5635 T21530 T21525 punct (,factor
R5636 T21531 T21525 nmod s,factor
R5637 T21365 T21366 compound mr,s
R5638 T21532 T21525 punct ),factor
R5639 T21533 T21534 dep which,interacts
R5640 T21534 T21525 relcl interacts,factor
R5641 T21366 T21362 nsubj s,forms
R5642 T21535 T21534 prep with,interacts
R5643 T21536 T21537 compound mr,s
R5644 T21537 T21535 pobj s,with
R5645 T21367 T21366 punct -,s
R5646 T21538 T21537 punct -,s
R5647 T21539 T21514 punct .,suppose
R5648 T21368 T21369 det a,polymer
R5649 T21541 T21542 advmod However,find
R5650 T21369 T21362 dobj polymer,forms
R5651 T21543 T21542 punct ", ",find
R5652 T21544 T21542 nsubj we,find
R5653 T21545 T21542 aux did,find
R5654 T21370 T21371 amod future,analysis
R5655 T21546 T21542 neg not,find
R5656 T21547 T21548 det any,factors
R5657 T21548 T21542 dobj factors,find
R5658 T21371 T21359 dobj analysis,awaits
R5659 T21549 T21548 compound transcription,factors
R5660 T21550 T21542 prep in,find
R5661 T21372 T21359 punct .,awaits
R5662 T21551 T21552 det the,screening
R5663 T21552 T21550 pobj screening,in
R5664 T21374 T21375 det A,report
R5665 T21553 T21552 amod present,screening
R5666 T21554 T21552 nmod yeast,screening
R5667 T21555 T21556 nummod two,hybrid
R5668 T21556 T21552 compound hybrid,screening
R5669 T21375 T21377 nsubj report,indicated
R5670 T21557 T21556 punct -,hybrid
R5671 T21558 T21542 punct .,find
R5672 T21376 T21375 amod previous,report
R5673 T21560 T21561 nsubj We,found
R5674 T21562 T21561 advmod also,found
R5675 T21378 T21379 mark that,contains
R5676 T21563 T21564 mark that,functions
R5677 T21564 T21561 ccomp functions,found
R5678 T21565 T21566 amod full,length
R5679 T21566 T21568 compound length,s
R5680 T21379 T21377 ccomp contains,indicated
R5681 T21567 T21566 punct -,length
R5682 T21568 T21564 nsubj s,functions
R5683 T21569 T21568 compound mr,s
R5684 T21380 T21379 nsubj TEL,contains
R5685 T21570 T21568 punct -,s
R5686 T21571 T21568 acl fused,s
R5687 T21572 T21571 prep to,fused
R5688 T21381 T21382 det a,domain
R5689 T21573 T21574 det the,domain
R5690 T21574 T21572 pobj domain,to
R5691 T21575 T21574 nmod GAL4,domain
R5692 T21382 T21379 dobj domain,contains
R5693 T21576 T21577 npadvmod DNA,binding
R5694 T21577 T21574 amod binding,domain
R5695 T21578 T21579 punct (,mrs
R5696 T21383 T21384 npadvmod sequence,specific
R5697 T21579 T21568 parataxis mrs,s
R5698 T21580 T21579 compound DBD,mrs
R5699 T21581 T21579 punct -,mrs
R5700 T21384 T21382 amod specific,domain
R5701 T21582 T21579 punct ),mrs
R5702 T21583 T21564 prep as,functions
R5703 T21584 T21585 det a,repressor
R5704 T21585 T21583 pobj repressor,as
R5705 T21586 T21585 amod transcriptional,repressor
R5706 T21587 T21561 punct .,found
R5707 T21595 T21593 acl involved,idea
R5708 T21589 T21590 nsubj This,support
R5709 T21591 T21590 aux may,support
R5710 T21592 T21593 det the,idea
R5711 T21596 T21597 compound mr,s
R5712 T21593 T21590 dobj idea,support
R5713 T21594 T21595 mark that,involved
R5714 T21597 T21595 nsubjpass s,involved
R5715 T21598 T21597 punct -,s
R5716 T21599 T21595 auxpass is,involved
R5717 T21600 T21595 prep in,involved
R5718 T21700 T21695 prep at,contains
R5719 T21701 T21702 det the,terminus
R5720 T21601 T21602 amod repressive,complexes
R5721 T21702 T21700 pobj terminus,at
R5722 T21703 T21702 compound C,terminus
R5723 T21602 T21600 pobj complexes,in
R5724 T21704 T21702 punct -,terminus
R5725 T21705 T21670 punct ", ",reported
R5726 T21706 T21670 auxpass was,reported
R5727 T21603 T21602 amod similar,complexes
R5728 T21707 T21670 prep as,reported
R5729 T21708 T21709 det a,repressor
R5730 T21604 T21603 prep to,similar
R5731 T21709 T21707 pobj repressor,as
R5732 T21710 T21709 amod transcriptional,repressor
R5733 T21711 T21670 cc and,reported
R5734 T21605 T21606 amod other,proteins
R5735 T21712 T21713 det the,activity
R5736 T21606 T21604 pobj proteins,to
R5737 T21713 T21715 nsubj activity,required
R5738 T21607 T21608 compound SAM,domain
R5739 T21714 T21713 compound repressor,activity
R5740 T21715 T21670 conj required,reported
R5741 T21608 T21609 npadvmod domain,containing
R5742 T21716 T21713 prep of,activity
R5743 T21717 T21718 nmod H,MBT
R5744 T21609 T21606 amod containing,proteins
R5745 T21718 T21716 pobj MBT,of
R5746 T21719 T21720 punct -,L
R5747 T21720 T21717 prep L,H
R5748 T21610 T21609 punct -,containing
R5749 T21721 T21722 punct (,3
R5750 T21722 T21717 parataxis 3,H
R5751 T21723 T21722 punct ),3
R5752 T21611 T21590 punct .,support
R5753 T21724 T21715 advmod mainly,required
R5754 T21725 T21726 det the,presence
R5755 T21726 T21715 dobj presence,required
R5756 T21727 T21726 prep of,presence
R5757 T21728 T21729 det the,repeats
R5758 T21613 T21614 poss Our,results
R5759 T21729 T21727 pobj repeats,of
R5760 T21730 T21729 compound MBT,repeats
R5761 T21731 T21729 cc but,repeats
R5762 T21732 T21731 neg not,but
R5763 T21733 T21734 det the,domain
R5764 T21614 T21615 nsubj results,showed
R5765 T21734 T21729 conj domain,repeats
R5766 T21735 T21734 compound SAM,domain
R5767 T21616 T21615 punct ", ",showed
R5768 T21736 T21737 punct [,45
R5769 T21737 T21715 parataxis 45,required
R5770 T21738 T21737 punct ],45
R5771 T21739 T21670 punct .,reported
R5772 T21617 T21615 advmod however,showed
R5773 T21741 T21742 aux To,determine
R5774 T21618 T21615 punct ", ",showed
R5775 T21742 T21743 advcl determine,performed
R5776 T21744 T21745 det the,region
R5777 T21619 T21620 mark that,is
R5778 T21745 T21742 dobj region,determine
R5779 T21746 T21745 amod transcriptional,region
R5780 T21747 T21745 compound repressor,region
R5781 T21620 T21615 ccomp is,showed
R5782 T21748 T21745 prep of,region
R5783 T21749 T21750 det the,protein
R5784 T21750 T21748 pobj protein,of
R5785 T21621 T21622 det the,association
R5786 T21751 T21752 compound mr,s
R5787 T21752 T21750 compound s,protein
R5788 T21753 T21752 punct -,s
R5789 T21622 T21620 nsubj association,is
R5790 T21754 T21743 punct ", ",performed
R5791 T21755 T21743 nsubj we,performed
R5792 T21756 T21757 det a,assay
R5793 T21623 T21622 compound self,association
R5794 T21757 T21743 dobj assay,performed
R5795 T21758 T21757 compound luciferase,assay
R5796 T21759 T21743 advcl using,performed
R5797 T21624 T21622 punct -,association
R5798 T21760 T21761 npadvmod site,directed
R5799 T21761 T21763 amod directed,mutants
R5800 T21762 T21761 punct -,directed
R5801 T21625 T21622 prep of,association
R5802 T21763 T21759 dobj mutants,using
R5803 T21764 T21765 punct (,W404A
R5804 T21765 T21743 parataxis W404A,performed
R5805 T21626 T21627 compound mr,s
R5806 T21766 T21765 compound DBD,W404A
R5807 T21767 T21765 punct -,W404A
R5808 T21768 T21765 cc and,W404A
R5809 T21769 T21770 compound DBD,G453A
R5810 T21770 T21765 conj G453A,W404A
R5811 T21771 T21770 punct -,G453A
R5812 T21772 T21765 punct ),W404A
R5813 T21627 T21625 pobj s,of
R5814 T21773 T21743 punct .,performed
R5815 T21775 T21776 det The,result
R5816 T21628 T21627 punct -,s
R5817 T21776 T21777 nsubj result,showed
R5818 T21778 T21779 mark that,compromises
R5819 T21629 T21622 prep through,association
R5820 T21779 T21777 ccomp compromises,showed
R5821 T21780 T21781 det the,ability
R5822 T21781 T21779 nsubj ability,compromises
R5823 T21630 T21631 poss its,domain
R5824 T21782 T21781 amod reduced,ability
R5825 T21783 T21781 compound binding,ability
R5826 T21631 T21629 pobj domain,through
R5827 T21784 T21781 prep of,ability
R5828 T21785 T21786 compound self,association
R5829 T21786 T21784 pobj association,of
R5830 T21632 T21631 compound SAM,domain
R5831 T21787 T21786 punct -,association
R5832 T21788 T21779 advmod partially,compromises
R5833 T21789 T21790 det the,activity
R5834 T21633 T21620 neg not,is
R5835 T21790 T21779 dobj activity,compromises
R5836 T21791 T21790 amod transcriptional,activity
R5837 T21634 T21620 acomp essential,is
R5838 T21792 T21790 amod repressive,activity
R5839 T21793 T21790 prep of,activity
R5840 T21794 T21795 compound mr,s
R5841 T21635 T21634 prep for,essential
R5842 T21795 T21793 pobj s,of
R5843 T21796 T21795 punct -,s
R5844 T21797 T21798 punct (,7D
R5845 T21636 T21637 det the,activity
R5846 T21637 T21635 pobj activity,for
R5847 T21798 T21779 parataxis 7D,compromises
R5848 T21638 T21637 amod transcriptional,activity
R5849 T21799 T21798 compound Fig.,7D
R5850 T21800 T21798 punct ),7D
R5851 T21801 T21777 punct .,showed
R5852 T21639 T21637 amod repressive,activity
R5853 T21640 T21615 punct .,showed
R5854 T21803 T21804 advmod However,was
R5855 T21642 T21643 nsubjpass Polymerization,reported
R5856 T21644 T21642 prep of,Polymerization
R5857 T21805 T21804 punct ", ",was
R5858 T21806 T21807 det the,effect
R5859 T21807 T21804 nsubj effect,was
R5860 T21808 T21807 amod repressive,effect
R5861 T21809 T21810 advmod more,significant
R5862 T21810 T21804 acomp significant,was
R5863 T21645 T21646 det the,domain
R5864 T21811 T21812 advmod when,co-introduced
R5865 T21812 T21804 advcl co-introduced,was
R5866 T21813 T21814 compound DBD,tail
R5867 T21646 T21644 pobj domain,of
R5868 T21647 T21646 compound SAM,domain
R5869 T21648 T21643 aux has,reported
R5870 T21814 T21812 nsubjpass tail,co-introduced
R5871 T21649 T21643 auxpass been,reported
R5872 T21815 T21814 punct -,tail
R5873 T21816 T21814 punct ", ",tail
R5874 T21817 T21818 dep which,contain
R5875 T21650 T21643 advmod previously,reported
R5876 T21818 T21814 relcl contain,tail
R5877 T21819 T21818 aux does,contain
R5878 T21651 T21652 aux to,be
R5879 T21820 T21818 neg not,contain
R5880 T21821 T21822 compound SAM,domain
R5881 T21822 T21818 dobj domain,contain
R5882 T21652 T21643 xcomp be,reported
R5883 T21823 T21812 punct ", ",co-introduced
R5884 T21824 T21812 auxpass was,co-introduced
R5885 T21825 T21812 prep with,co-introduced
R5886 T21653 T21652 acomp essential,be
R5887 T21826 T21827 det the,plasmid
R5888 T21827 T21825 pobj plasmid,with
R5889 T21654 T21653 prep for,essential
R5890 T21828 T21829 compound 5xGAL4,pGL3
R5891 T21829 T21827 compound pGL3,plasmid
R5892 T21830 T21829 punct -,pGL3
R5893 T21655 T21656 det the,functions
R5894 T21831 T21827 compound reporter,plasmid
R5895 T21832 T21804 punct .,was
R5896 T21656 T21654 pobj functions,for
R5897 T21834 T21835 advmod Therefore,conclude
R5898 T21657 T21656 amod repressive,functions
R5899 T21836 T21835 punct ", ",conclude
R5900 T21837 T21835 nsubj we,conclude
R5901 T21838 T21839 mark that,is
R5902 T21658 T21656 prep of,functions
R5903 T21839 T21835 ccomp is,conclude
R5904 T21840 T21841 det a,region
R5905 T21659 T21658 pobj ph,of
R5906 T21841 T21839 nsubj region,is
R5907 T21842 T21841 prep from,region
R5908 T21843 T21844 nmod amino,463
R5909 T21660 T21659 cc and,ph
R5910 T21844 T21842 pobj 463,from
R5911 T21845 T21844 nmod acids,463
R5912 T21846 T21844 prep to,463
R5913 T21847 T21846 pobj 542,to
R5914 T21848 T21849 advmod mainly,responsible
R5915 T21849 T21839 acomp responsible,is
R5916 T21661 T21659 conj TEL,ph
R5917 T21850 T21849 prep for,responsible
R5918 T21851 T21852 det the,activity
R5919 T21852 T21850 pobj activity,for
R5920 T21662 T21663 punct [,44
R5921 T21853 T21852 compound repressor,activity
R5922 T21854 T21839 prep in,is
R5923 T21855 T21856 det the,case
R5924 T21663 T21643 parataxis 44,reported
R5925 T21856 T21854 pobj case,in
R5926 T21857 T21856 prep of,case
R5927 T21664 T21663 nummod 43,44
R5928 T21858 T21859 compound mr,s
R5929 T21859 T21857 pobj s,of
R5930 T21860 T21859 punct -,s
R5931 T21665 T21663 punct ",",44
R5932 T21861 T21835 punct .,conclude
R5933 T21666 T21663 punct ],44
R5934 T21863 T21864 amod Evolutionary,conservation
R5935 T21864 T21865 nsubj conservation,underlie
R5936 T21667 T21643 punct .,reported
R5937 T21866 T21864 prep of,conservation
R5938 T21867 T21868 det the,region
R5939 T21868 T21866 pobj region,of
R5940 T21669 T21670 prep On,reported
R5941 T21869 T21870 npadvmod C,terminal
R5942 T21870 T21868 amod terminal,region
R5943 T21871 T21870 punct -,terminal
R5944 T21671 T21672 det the,hand
R5945 T21872 T21873 nummod 80,aa
R5946 T21873 T21868 compound aa,region
R5947 T21874 T21868 prep of,region
R5948 T21875 T21876 compound mr,s
R5949 T21672 T21669 pobj hand,On
R5950 T21876 T21874 pobj s,of
R5951 T21877 T21876 punct -,s
R5952 T21673 T21672 amod other,hand
R5953 T21878 T21864 prep from,conservation
R5954 T21879 T21878 pobj zebrafish,from
R5955 T21880 T21878 prep through,from
R5956 T21674 T21670 punct ", ",reported
R5957 T21881 T21880 pobj human,through
R5958 T21882 T21865 aux may,underlie
R5959 T21883 T21884 det the,importance
R5960 T21675 T21676 amod human,protein
R5961 T21884 T21865 dobj importance,underlie
R5962 T21885 T21884 amod functional,importance
R5963 T21676 T21670 nsubjpass protein,reported
R5964 T21886 T21884 prep of,importance
R5965 T21887 T21888 det this,region
R5966 T21888 T21886 pobj region,of
R5967 T21677 T21676 amod lethal,protein
R5968 T21889 T21865 punct .,underlie
R5969 T21891 T21892 nummod Two,complexes
R5970 T21678 T21679 punct (,3
R5971 T21892 T21896 nsubjpass complexes,identified
R5972 T21893 T21892 amod distinct,complexes
R5973 T21679 T21677 parataxis 3,lethal
R5974 T21894 T21892 compound multiprotein,complexes
R5975 T21895 T21892 compound PcG,complexes
R5976 T21680 T21679 punct ),3
R5977 T21897 T21892 punct ", ",complexes
R5978 T21898 T21892 appos PRC1,complexes
R5979 T21681 T21682 amod malignant,tumor
R5980 T21899 T21898 cc and,PRC1
R5981 T21900 T21898 conj PRC2,PRC1
R5982 T21901 T21896 punct ", ",identified
R5983 T21682 T21676 nmod tumor,protein
R5984 T21902 T21896 aux have,identified
R5985 T21903 T21896 auxpass been,identified
R5986 T21683 T21682 nmod brain,tumor
R5987 T21904 T21896 punct .,identified
R5988 T21906 T21907 nsubjpass PRC2,involved
R5989 T21684 T21685 punct (,3
R5990 T21908 T21907 auxpass is,involved
R5991 T21909 T21907 prep in,involved
R5992 T21685 T21682 parataxis 3,tumor
R5993 T21910 T21911 det the,initiation
R5994 T21686 T21685 dep H,3
R5995 T21687 T21688 punct -,L
R5996 T21688 T21686 prep L,H
R5997 T21911 T21909 pobj initiation,in
R5998 T21912 T21911 prep of,initiation
R5999 T21913 T21912 pobj silencing,of
R6000 T21689 T21685 punct (,3
R6001 T21914 T21907 cc and,involved
R6002 T21915 T21907 conj contains,involved
R6003 T21690 T21685 punct ),3
R6004 T21916 T21917 compound histone,deacetylases
R6005 T21917 T21915 dobj deacetylases,contains
R6006 T21918 T21917 punct (,deacetylases
R6007 T21691 T21682 appos MBT,tumor
R6008 T21919 T21917 appos HDACs,deacetylases
R6009 T21692 T21676 punct ),protein
R6010 T21920 T21917 punct ),deacetylases
R6011 T21921 T21917 cc and,deacetylases
R6012 T21922 T21923 compound histone,methyltransferases
R6013 T21923 T21917 conj methyltransferases,deacetylases
R6014 T21693 T21676 punct ", ",protein
R6015 T21924 T21917 punct ", ",deacetylases
R6016 T21925 T21926 dep which,methylate
R6017 T21926 T21917 relcl methylate,deacetylases
R6018 T21927 T21926 aux can,methylate
R6019 T21928 T21929 nmod histone,9
R6020 T21929 T21926 dobj 9,methylate
R6021 T21694 T21695 dep which,contains
R6022 T21930 T21929 nmod H3,9
R6023 T21931 T21929 nmod lysine,9
R6024 T21932 T21929 cc and,9
R6025 T21695 T21676 relcl contains,protein
R6026 T21933 T21929 conj 27,9
R6027 T21934 T21929 punct ", ",9
R6028 T21935 T21929 appos marks,9
R6029 T21696 T21695 advmod also,contains
R6030 T21936 T21935 prep of,marks
R6031 T21937 T21938 amod silenced,chromatin
R6032 T21938 T21936 pobj chromatin,of
R6033 T21697 T21698 det a,domain
R6034 T21939 T21907 punct .,involved
R6035 T21941 T21942 nsubj PRC1,recognizes
R6036 T21698 T21695 dobj domain,contains
R6037 T21943 T21941 punct ", ",PRC1
R6038 T21699 T21698 compound SAM,domain
R6039 T21944 T21941 prep including,PRC1
R6040 T21945 T21944 pobj ph,including
R6041 T21946 T21942 punct ", ",recognizes
R6042 T22017 T22018 poss Our,assay
R6043 T21947 T21948 det the,mark
R6044 T21948 T21942 dobj mark,recognizes
R6045 T21949 T21948 nmod histone,mark
R6046 T21950 T21948 nmod H3,mark
R6047 T22018 T22020 nsubj assay,showed
R6048 T21951 T21948 nmod lysine,mark
R6049 T21952 T21951 nummod 27,lysine
R6050 T21953 T21948 acl set,mark
R6051 T22019 T22018 compound luciferase,assay
R6052 T21954 T21953 agent by,set
R6053 T21955 T21954 pobj PRC2,by
R6054 T22021 T22020 advmod also,showed
R6055 T21956 T21942 cc and,recognizes
R6056 T21957 T21942 conj maintains,recognizes
R6057 T21958 T21959 det a,state
R6058 T21959 T21957 dobj state,maintains
R6059 T22022 T22023 mark that,affected
R6060 T21960 T21959 amod stable,state
R6061 T22023 T22020 ccomp affected,showed
R6062 T21961 T21959 prep of,state
R6063 T21962 T21963 compound gene,repression
R6064 T21963 T21961 pobj repression,of
R6065 T21964 T21965 prep in,blocks
R6066 T22024 T22025 amod transcriptional,repression
R6067 T21965 T21959 relcl blocks,state
R6068 T21966 T21964 pobj which,in
R6069 T21967 T21965 nsubj PRC1,blocks
R6070 T21968 T21969 compound chromatin,remodeling
R6071 T21969 T21965 dobj remodeling,blocks
R6072 T21970 T21969 prep by,remodeling
R6073 T22025 T22023 nsubjpass repression,affected
R6074 T21971 T21972 det the,complex
R6075 T22026 T22025 prep of,repression
R6076 T21972 T21970 pobj complex,by
R6077 T22027 T22028 compound DBD,mrs
R6078 T21973 T21972 nmod trithorax,complex
R6079 T21974 T21975 npadvmod group,related
R6080 T22028 T22026 pobj mrs,of
R6081 T21975 T21972 amod related,complex
R6082 T21976 T21975 punct -,related
R6083 T21977 T21978 compound SWI,SNF
R6084 T22029 T22028 punct -,mrs
R6085 T21978 T21972 compound SNF,complex
R6086 T21979 T21978 punct -,SNF
R6087 T22030 T22023 auxpass was,affected
R6088 T21980 T21981 punct [,47
R6089 T21981 T21965 parataxis 47,blocks
R6090 T22031 T22023 neg not,affected
R6091 T21982 T21981 nummod 46,47
R6092 T21983 T21981 punct ",",47
R6093 T21984 T21981 punct ],47
R6094 T22032 T22023 agent by,affected
R6095 T21985 T21942 punct .,recognizes
R6096 T22033 T22034 det the,addition
R6097 T21987 T21988 advmod Therefore,thought
R6098 T21989 T21988 punct ", ",thought
R6099 T22034 T22032 pobj addition,by
R6100 T21990 T21991 det the,mechanism
R6101 T21991 T21988 nsubjpass mechanism,thought
R6102 T21992 T21991 prep of,mechanism
R6103 T22035 T22034 prep of,addition
R6104 T21993 T21992 pobj repression,of
R6105 T21994 T21993 prep by,repression
R6106 T21995 T21994 pobj PRC2,by
R6107 T22036 T22037 amod various,concentrations
R6108 T21996 T21988 auxpass is,thought
R6109 T21997 T21998 aux to,be
R6110 T22037 T22035 pobj concentrations,of
R6111 T21998 T21988 xcomp be,thought
R6112 T21999 T22000 npadvmod HDAC,dependent
R6113 T22000 T21998 acomp dependent,be
R6114 T22038 T22037 prep of,concentrations
R6115 T22001 T22000 punct -,dependent
R6116 T22039 T22040 compound trichostatin,A
R6117 T22002 T22003 mark while,appears
R6118 T22003 T21988 advcl appears,thought
R6119 T22004 T22005 det the,mechanism
R6120 T22005 T22003 nsubj mechanism,appears
R6121 T22006 T22005 prep of,mechanism
R6122 T22007 T22006 pobj repression,of
R6123 T22008 T22007 prep by,repression
R6124 T22040 T22038 pobj A,of
R6125 T22009 T22008 pobj PRC1,by
R6126 T22010 T22011 aux to,be
R6127 T22011 T22003 xcomp be,appears
R6128 T22041 T22040 punct ", ",A
R6129 T22012 T22013 npadvmod HDAC,independent
R6130 T22013 T22011 acomp independent,be
R6131 T22014 T22013 punct -,independent
R6132 T22042 T22043 det a,inhibitor
R6133 T22015 T21988 punct .,thought
R6134 T22043 T22040 appos inhibitor,A
R6135 T22044 T22043 amod potent,inhibitor
R6136 T22045 T22043 compound HDAC,inhibitor
R6137 T22046 T22047 punct (,shown
R6138 T22124 T22123 advmod also,revealed
R6139 T22125 T22126 mark that,is
R6140 T22047 T22020 parataxis shown,showed
R6141 T22126 T22123 ccomp is,revealed
R6142 T22127 T22128 det the,activity
R6143 T22128 T22126 nsubj activity,is
R6144 T22048 T22047 nsubj data,shown
R6145 T22129 T22128 amod repressive,activity
R6146 T22130 T22128 prep of,activity
R6147 T22049 T22047 neg not,shown
R6148 T22131 T22132 compound mr,s
R6149 T22132 T22130 pobj s,of
R6150 T22133 T22132 punct -,s
R6151 T22050 T22047 punct ),shown
R6152 T22134 T22135 advmod mainly,due
R6153 T22135 T22126 prep due,is
R6154 T22136 T22135 pcomp to,due
R6155 T22051 T22020 punct .,showed
R6156 T22137 T22138 det the,region
R6157 T22138 T22135 pobj region,due
R6158 T22139 T22140 npadvmod C,terminal
R6159 T22053 T22054 advmod Therefore,speculate
R6160 T22140 T22138 amod terminal,region
R6161 T22141 T22140 punct -,terminal
R6162 T22142 T22143 punct (,463
R6163 T22055 T22054 punct ", ",speculate
R6164 T22143 T22138 parataxis 463,region
R6165 T22056 T22054 nsubj we,speculate
R6166 T22144 T22143 nmod amino,463
R6167 T22145 T22143 nmod acids,463
R6168 T22057 T22058 mark that,be
R6169 T22146 T22143 prep to,463
R6170 T22147 T22146 pobj 542,to
R6171 T22148 T22143 punct ),463
R6172 T22149 T22123 punct .,revealed
R6173 T22151 T22152 advmod However,remain
R6174 T22058 T22054 ccomp be,speculate
R6175 T22153 T22152 punct ", ",remain
R6176 T22154 T22155 amod downstream,targets
R6177 T22059 T22060 det the,mechanism
R6178 T22155 T22152 nsubj targets,remain
R6179 T22156 T22155 prep of,targets
R6180 T22060 T22058 nsubj mechanism,be
R6181 T22157 T22158 compound mr,s
R6182 T22158 T22156 pobj s,of
R6183 T22061 T22060 prep of,mechanism
R6184 T22159 T22158 punct -,s
R6185 T22160 T22152 advmod still,remain
R6186 T22161 T22152 acomp unclear,remain
R6187 T22062 T22061 pobj repression,of
R6188 T22162 T22152 punct .,remain
R6189 T22164 T22165 advmod In,situ
R6190 T22063 T22062 prep of,repression
R6191 T22165 T22166 amod situ,hybridization
R6192 T22166 T22167 nsubj hybridization,showed
R6193 T22064 T22065 compound mr,s
R6194 T22168 T22169 mark that,is
R6195 T22169 T22167 ccomp is,showed
R6196 T22065 T22063 pobj s,of
R6197 T22170 T22171 det the,peak
R6198 T22171 T22169 nsubj peak,is
R6199 T22172 T22171 prep of,peak
R6200 T22066 T22065 punct -,s
R6201 T22173 T22174 compound mr,s
R6202 T22174 T22176 compound s,expression
R6203 T22175 T22174 punct -,s
R6204 T22067 T22058 aux may,be
R6205 T22176 T22172 pobj expression,of
R6206 T22177 T22178 advmod around,P6
R6207 T22178 T22169 attr P6,is
R6208 T22068 T22069 npadvmod HDAC,independent
R6209 T22179 T22178 punct ", ",P6
R6210 T22180 T22181 advmod when,undergo
R6211 T22069 T22058 acomp independent,be
R6212 T22181 T22178 relcl undergo,P6
R6213 T22182 T22183 amod retinal,photoreceptors
R6214 T22183 T22181 nsubj photoreceptors,undergo
R6215 T22070 T22069 punct -,independent
R6216 T22184 T22185 amod terminal,differentiation
R6217 T22185 T22181 dobj differentiation,undergo
R6218 T22186 T22167 punct .,showed
R6219 T22071 T22069 cc and,independent
R6220 T22188 T22189 nsubj We,hypothesize
R6221 T22072 T22073 advmod more,similar
R6222 T22190 T22191 mark that,be
R6223 T22191 T22189 ccomp be,hypothesize
R6224 T22192 T22193 det the,genes
R6225 T22193 T22191 nsubj genes,be
R6226 T22194 T22193 compound target,genes
R6227 T22195 T22193 prep of,genes
R6228 T22073 T22069 conj similar,independent
R6229 T22196 T22197 compound mr,s
R6230 T22197 T22195 pobj s,of
R6231 T22198 T22197 punct -,s
R6232 T22074 T22073 prep to,similar
R6233 T22199 T22191 aux might,be
R6234 T22200 T22201 amod non-photoreceptor,genes
R6235 T22201 T22191 attr genes,be
R6236 T22075 T22074 pobj that,to
R6237 T22202 T22189 punct .,hypothesize
R6238 T22076 T22075 prep of,that
R6239 T22204 T22205 prep In,suppress
R6240 T22206 T22207 det this,case
R6241 T22077 T22078 compound PRC1,complex
R6242 T22207 T22204 pobj case,In
R6243 T22078 T22076 pobj complex,of
R6244 T22079 T22054 punct .,speculate
R6245 T22081 T22082 prep In,demonstrate
R6246 T22208 T22205 punct ", ",suppress
R6247 T22209 T22210 compound mr,s
R6248 T22083 T22084 det the,study
R6249 T22210 T22205 nsubj s,suppress
R6250 T22211 T22210 punct -,s
R6251 T22212 T22205 aux may,suppress
R6252 T22213 T22214 det the,expression
R6253 T22084 T22081 pobj study,In
R6254 T22214 T22205 dobj expression,suppress
R6255 T22215 T22214 prep of,expression
R6256 T22085 T22084 amod present,study
R6257 T22216 T22217 amod non-photoreceptor,genes
R6258 T22217 T22215 pobj genes,of
R6259 T22218 T22205 prep in,suppress
R6260 T22086 T22082 punct ", ",demonstrate
R6261 T22219 T22220 nmod rod,photoreceptors
R6262 T22220 T22218 pobj photoreceptors,in
R6263 T22221 T22219 cc and,rod
R6264 T22087 T22088 det the,experiments
R6265 T22222 T22219 conj cone,rod
R6266 T22223 T22205 punct .,suppress
R6267 T22088 T22082 nsubj experiments,demonstrate
R6268 T22225 T22226 expl There,be
R6269 T22227 T22226 aux may,be
R6270 T22089 T22088 amod biochemical,experiments
R6271 T22228 T22229 det another,possibility
R6272 T22090 T22091 mark that,functions
R6273 T22091 T22082 ccomp functions,demonstrate
R6274 T22092 T22093 det the,protein
R6275 T22229 T22226 attr possibility,be
R6276 T22230 T22231 mark that,involved
R6277 T22231 T22229 acl involved,possibility
R6278 T22232 T22233 compound mr,s
R6279 T22233 T22231 nsubjpass s,involved
R6280 T22093 T22091 nsubj protein,functions
R6281 T22234 T22233 punct -,s
R6282 T22235 T22231 auxpass is,involved
R6283 T22094 T22095 compound mr,s
R6284 T22095 T22093 compound s,protein
R6285 T22236 T22231 prep in,involved
R6286 T22237 T22238 compound cell,fate
R6287 T22238 T22239 compound fate,determination
R6288 T22096 T22095 punct -,s
R6289 T22239 T22236 pobj determination,in
R6290 T22240 T22239 prep of,determination
R6291 T22097 T22091 prep as,functions
R6292 T22241 T22242 compound rod,photoreceptors
R6293 T22242 T22240 pobj photoreceptors,of
R6294 T22243 T22242 cc versus,photoreceptors
R6295 T22098 T22099 det a,repressor
R6296 T22244 T22245 compound cone,photoreceptors
R6297 T22245 T22242 conj photoreceptors,photoreceptors
R6298 T22099 T22097 pobj repressor,as
R6299 T22246 T22226 punct .,be
R6300 T22248 T22249 mark While,born
R6301 T22100 T22099 amod transcriptional,repressor
R6302 T22249 T22253 advcl born,born
R6303 T22250 T22251 compound cone,photoreceptors
R6304 T22101 T22091 cc and,functions
R6305 T22251 T22249 nsubjpass photoreceptors,born
R6306 T22252 T22249 auxpass are,born
R6307 T22102 T22103 advmod possibly,regulates
R6308 T22254 T22249 prep during,born
R6309 T22255 T22256 det the,stages
R6310 T22256 T22254 pobj stages,during
R6311 T22103 T22091 conj regulates,functions
R6312 T22257 T22258 amod early,embryonic
R6313 T22258 T22256 amod embryonic,stages
R6314 T22104 T22103 advmod down,regulates
R6315 T22259 T22256 prep of,stages
R6316 T22260 T22261 compound mouse,retinogenesis
R6317 T22261 T22259 pobj retinogenesis,of
R6318 T22105 T22103 punct -,regulates
R6319 T22262 T22253 punct ", ",born
R6320 T22263 T22264 compound rod,photoreceptors
R6321 T22106 T22107 det the,expression
R6322 T22264 T22253 nsubjpass photoreceptors,born
R6323 T22265 T22253 auxpass are,born
R6324 T22266 T22253 advmod primarily,born
R6325 T22107 T22103 dobj expression,regulates
R6326 T22267 T22253 prep in,born
R6327 T22268 T22269 det the,period
R6328 T22269 T22267 pobj period,in
R6329 T22270 T22271 amod late,embryonic
R6330 T22271 T22269 amod embryonic,period
R6331 T22108 T22107 amod spatial,expression
R6332 T22272 T22271 cc and,embryonic
R6333 T22273 T22274 amod early,postnatal
R6334 T22274 T22271 conj postnatal,embryonic
R6335 T22275 T22276 punct [,48
R6336 T22109 T22108 cc and,spatial
R6337 T22276 T22253 parataxis 48,born
R6338 T22277 T22276 punct ],48
R6339 T22110 T22108 conj temporal,spatial
R6340 T22278 T22253 punct .,born
R6341 T22280 T22281 det The,pattern
R6342 T22111 T22107 prep of,expression
R6343 T22281 T22283 nsubj pattern,suggest
R6344 T22282 T22281 compound expression,pattern
R6345 T22112 T22113 det the,genes
R6346 T22284 T22281 prep of,pattern
R6347 T22285 T22286 compound mr,s
R6348 T22113 T22111 pobj genes,of
R6349 T22286 T22284 pobj s,of
R6350 T22287 T22286 punct -,s
R6351 T22288 T22283 aux may,suggest
R6352 T22114 T22113 compound target,genes
R6353 T22289 T22290 mark that,expressed
R6354 T22290 T22283 ccomp expressed,suggest
R6355 T22291 T22292 compound mr,s
R6356 T22115 T22103 prep during,regulates
R6357 T22292 T22290 nsubjpass s,expressed
R6358 T22293 T22292 punct -,s
R6359 T22116 T22117 amod retinal,development
R6360 T22294 T22290 auxpass is,expressed
R6361 T22295 T22290 prep in,expressed
R6362 T22296 T22297 compound rod,photoreceptors
R6363 T22117 T22115 pobj development,during
R6364 T22297 T22295 pobj photoreceptors,in
R6365 T22298 T22295 cc but,in
R6366 T22299 T22298 neg not,but
R6367 T22118 T22117 compound photoreceptor,development
R6368 T22300 T22295 conj in,in
R6369 T22301 T22302 compound cone,photoreceptors
R6370 T22302 T22300 pobj photoreceptors,in
R6371 T22303 T22304 advmod as,as
R6372 T22119 T22082 punct .,demonstrate
R6373 T22304 T22302 cc as,photoreceptors
R6374 T22305 T22304 advmod well,as
R6375 T22306 T22302 conj Nr2e3,photoreceptors
R6376 T22121 T22122 poss Our,data
R6377 T22307 T22306 punct ", ",Nr2e3
R6378 T22308 T22309 dep which,known
R6379 T22309 T22306 relcl known,Nr2e3
R6380 T22310 T22309 auxpass is,known
R6381 T22311 T22309 prep as,known
R6382 T22312 T22313 det a,repressor
R6383 T22313 T22311 pobj repressor,as
R6384 T22122 T22123 nsubj data,revealed
R6385 T22314 T22313 amod transcriptional,repressor
R6386 T22315 T22309 cc and,known
R6387 T22316 T22317 auxpass is,thought
R6389 T22317 T22309 conj thought,known
R6390 T22318 T22319 aux to,regulate
R6394 T22320 T22319 advmod down,regulate
R6396 T22321 T22319 punct -,regulate
R6388 T22335 T22333 prep of,function
R6391 T22336 T22337 compound mr,s
R6392 T22337 T22335 pobj s,of
R6393 T22319 T22317 xcomp regulate,thought
R6395 T22338 T22337 punct -,s
R6397 T22322 T22323 nmod cone,genes
R6398 T22323 T22319 dobj genes,regulate
R6399 T22339 T22331 punct ", ",be
R6400 T22324 T22325 npadvmod photoreceptor,specific
R6401 T22325 T22323 amod specific,genes
R6402 T22340 T22331 nsubj analysis,be
R6403 T22326 T22325 punct -,specific
R6404 T22327 T22283 punct .,suggest
R6405 T22341 T22340 prep of,analysis
R6406 T22329 T22330 aux To,clarify
R6407 T22330 T22331 advcl clarify,be
R6408 T22342 T22341 pobj mice,of
R6409 T22332 T22333 det the,function
R6410 T22343 T22342 prep with,mice
R6411 T22333 T22330 dobj function,clarify
R6412 T22334 T22333 amod biological,function
R6413 T22344 T22345 amod targeted,disruptions
R6414 T22345 T22343 pobj disruptions,with
R6415 T22346 T22345 prep of,disruptions
R6416 T22347 T22348 compound mr,s
R6417 T22348 T22346 pobj s,of
R6418 T22349 T22348 punct -,s
R6419 T22350 T22331 aux will,be
R6420 T22351 T22352 advmod very,important
R6421 T22352 T22331 acomp important,be
R6422 T22353 T22331 punct .,be