Id |
Subject |
Object |
Predicate |
Lexical cue |
T20693 |
11-13 |
IN |
denotes |
In |
T20694 |
36-46 |
VBD |
denotes |
identified |
T20695 |
14-17 |
DT |
denotes |
the |
T20696 |
26-31 |
NN |
denotes |
study |
T20697 |
18-25 |
JJ |
denotes |
present |
T20698 |
31-33 |
, |
denotes |
, |
T20699 |
33-35 |
PRP |
denotes |
we |
T20700 |
47-48 |
DT |
denotes |
a |
T20701 |
55-59 |
NN |
denotes |
gene |
T20702 |
49-54 |
JJ |
denotes |
novel |
T20703 |
59-61 |
, |
denotes |
, |
T20704 |
61-63 |
NN |
denotes |
mr |
T20705 |
64-65 |
NN |
denotes |
s |
T20706 |
63-64 |
HYPH |
denotes |
- |
T20707 |
65-67 |
, |
denotes |
, |
T20708 |
67-72 |
WDT |
denotes |
which |
T20709 |
90-99 |
VBN |
denotes |
expressed |
T20710 |
73-75 |
VBZ |
denotes |
is |
T20711 |
76-89 |
RB |
denotes |
predominantly |
T20712 |
100-102 |
IN |
denotes |
in |
T20713 |
103-110 |
JJ |
denotes |
retinal |
T20714 |
111-125 |
NNS |
denotes |
photoreceptors |
T20715 |
126-129 |
CC |
denotes |
and |
T20716 |
130-133 |
DT |
denotes |
the |
T20717 |
141-146 |
NN |
denotes |
gland |
T20718 |
134-140 |
JJ |
denotes |
pineal |
T20719 |
146-147 |
. |
denotes |
. |
T20720 |
147-214 |
sentence |
denotes |
The peak of mr-s expression in the developing retina is around P6. |
T20721 |
148-151 |
DT |
denotes |
The |
T20722 |
152-156 |
NN |
denotes |
peak |
T20723 |
201-203 |
VBZ |
denotes |
is |
T20724 |
157-159 |
IN |
denotes |
of |
T20725 |
160-162 |
NN |
denotes |
mr |
T20726 |
163-164 |
NN |
denotes |
s |
T20727 |
162-163 |
HYPH |
denotes |
- |
T20728 |
165-175 |
NN |
denotes |
expression |
T20729 |
176-178 |
IN |
denotes |
in |
T20730 |
179-182 |
DT |
denotes |
the |
T20731 |
194-200 |
NN |
denotes |
retina |
T20732 |
183-193 |
VBG |
denotes |
developing |
T20733 |
204-210 |
IN |
denotes |
around |
T20734 |
211-213 |
NN |
denotes |
P6 |
T20735 |
213-214 |
. |
denotes |
. |
T20736 |
214-335 |
sentence |
denotes |
This expression pattern correlates with the rapid increase of Crx, rhodopsin and other photoreceptor genes around P6-P8. |
T20737 |
215-219 |
DT |
denotes |
This |
T20738 |
231-238 |
NN |
denotes |
pattern |
T20739 |
220-230 |
NN |
denotes |
expression |
T20740 |
239-249 |
VBZ |
denotes |
correlates |
T20741 |
250-254 |
IN |
denotes |
with |
T20742 |
255-258 |
DT |
denotes |
the |
T20743 |
265-273 |
NN |
denotes |
increase |
T20744 |
259-264 |
JJ |
denotes |
rapid |
T20745 |
274-276 |
IN |
denotes |
of |
T20746 |
277-280 |
NN |
denotes |
Crx |
T20747 |
280-282 |
, |
denotes |
, |
T20748 |
282-291 |
NN |
denotes |
rhodopsin |
T20749 |
292-295 |
CC |
denotes |
and |
T20750 |
296-301 |
JJ |
denotes |
other |
T20751 |
316-321 |
NNS |
denotes |
genes |
T20752 |
302-315 |
NN |
denotes |
photoreceptor |
T20753 |
322-328 |
IN |
denotes |
around |
T20754 |
329-331 |
NN |
denotes |
P6 |
T20755 |
331-332 |
SYM |
denotes |
- |
T20756 |
332-334 |
NN |
denotes |
P8 |
T20757 |
334-335 |
. |
denotes |
. |
T20758 |
335-458 |
sentence |
denotes |
Around P6, the outer plexiform layer becomes visible and the outer layer of retina separates into two layers, ONL and INL. |
T20759 |
336-342 |
IN |
denotes |
Around |
T20760 |
373-380 |
VBZ |
denotes |
becomes |
T20761 |
343-345 |
NN |
denotes |
P6 |
T20762 |
345-347 |
, |
denotes |
, |
T20763 |
347-350 |
DT |
denotes |
the |
T20764 |
367-372 |
NN |
denotes |
layer |
T20765 |
351-356 |
JJ |
denotes |
outer |
T20766 |
357-366 |
NN |
denotes |
plexiform |
T20767 |
381-388 |
JJ |
denotes |
visible |
T20768 |
389-392 |
CC |
denotes |
and |
T20769 |
393-396 |
DT |
denotes |
the |
T20770 |
403-408 |
NN |
denotes |
layer |
T20771 |
397-402 |
JJ |
denotes |
outer |
T20772 |
419-428 |
VBZ |
denotes |
separates |
T20773 |
409-411 |
IN |
denotes |
of |
T20774 |
412-418 |
NN |
denotes |
retina |
T20775 |
429-433 |
IN |
denotes |
into |
T20776 |
434-437 |
CD |
denotes |
two |
T20777 |
438-444 |
NNS |
denotes |
layers |
T20778 |
444-446 |
, |
denotes |
, |
T20779 |
446-449 |
NN |
denotes |
ONL |
T20780 |
450-453 |
CC |
denotes |
and |
T20781 |
454-457 |
NN |
denotes |
INL |
T20782 |
457-458 |
. |
denotes |
. |
T20783 |
458-561 |
sentence |
denotes |
At the same time, photoreceptors begin to undergo terminal differentiation, forming the outer segment. |
T20784 |
459-461 |
IN |
denotes |
At |
T20785 |
492-497 |
VBP |
denotes |
begin |
T20786 |
462-465 |
DT |
denotes |
the |
T20787 |
471-475 |
NN |
denotes |
time |
T20788 |
466-470 |
JJ |
denotes |
same |
T20789 |
475-477 |
, |
denotes |
, |
T20790 |
477-491 |
NNS |
denotes |
photoreceptors |
T20791 |
498-500 |
TO |
denotes |
to |
T20792 |
501-508 |
VB |
denotes |
undergo |
T20793 |
509-517 |
JJ |
denotes |
terminal |
T20794 |
518-533 |
NN |
denotes |
differentiation |
T20795 |
533-535 |
, |
denotes |
, |
T20796 |
535-542 |
VBG |
denotes |
forming |
T20797 |
543-546 |
DT |
denotes |
the |
T20798 |
553-560 |
NN |
denotes |
segment |
T20799 |
547-552 |
JJ |
denotes |
outer |
T20800 |
560-561 |
. |
denotes |
. |
T20801 |
561-658 |
sentence |
denotes |
We therefore hypothesized that mr-s is a key molecule in the late development of photoreceptors. |
T20802 |
562-564 |
PRP |
denotes |
We |
T20803 |
575-587 |
VBD |
denotes |
hypothesized |
T20804 |
565-574 |
RB |
denotes |
therefore |
T20805 |
588-592 |
IN |
denotes |
that |
T20806 |
598-600 |
VBZ |
denotes |
is |
T20807 |
593-595 |
NN |
denotes |
mr |
T20808 |
596-597 |
NN |
denotes |
s |
T20809 |
595-596 |
HYPH |
denotes |
- |
T20810 |
601-602 |
DT |
denotes |
a |
T20811 |
607-615 |
NN |
denotes |
molecule |
T20812 |
603-606 |
JJ |
denotes |
key |
T20813 |
616-618 |
IN |
denotes |
in |
T20814 |
619-622 |
DT |
denotes |
the |
T20815 |
628-639 |
NN |
denotes |
development |
T20816 |
623-627 |
JJ |
denotes |
late |
T20817 |
640-642 |
IN |
denotes |
of |
T20818 |
643-657 |
NNS |
denotes |
photoreceptors |
T20819 |
657-658 |
. |
denotes |
. |
T20820 |
658-807 |
sentence |
denotes |
We previously reported that Otx2 and Crx have a critical role in photoreceptor development and that Otx2 directly regulates Crx transcription [3,9]. |
T20821 |
659-661 |
PRP |
denotes |
We |
T20822 |
673-681 |
VBD |
denotes |
reported |
T20823 |
662-672 |
RB |
denotes |
previously |
T20824 |
682-686 |
IN |
denotes |
that |
T20825 |
700-704 |
VBP |
denotes |
have |
T20826 |
687-691 |
NN |
denotes |
Otx2 |
T20827 |
692-695 |
CC |
denotes |
and |
T20828 |
696-699 |
NN |
denotes |
Crx |
T20829 |
705-706 |
DT |
denotes |
a |
T20830 |
716-720 |
NN |
denotes |
role |
T20831 |
707-715 |
JJ |
denotes |
critical |
T20832 |
721-723 |
IN |
denotes |
in |
T20833 |
724-737 |
NN |
denotes |
photoreceptor |
T20834 |
738-749 |
NN |
denotes |
development |
T20835 |
750-753 |
CC |
denotes |
and |
T20836 |
754-758 |
IN |
denotes |
that |
T20837 |
773-782 |
VBZ |
denotes |
regulates |
T20838 |
759-763 |
NN |
denotes |
Otx2 |
T20839 |
764-772 |
RB |
denotes |
directly |
T20840 |
783-786 |
NN |
denotes |
Crx |
T20841 |
787-800 |
NN |
denotes |
transcription |
T20842 |
801-802 |
-LRB- |
denotes |
[ |
T20843 |
804-805 |
CD |
denotes |
9 |
T20844 |
802-803 |
CD |
denotes |
3 |
T20845 |
803-804 |
, |
denotes |
, |
T20846 |
805-806 |
-RRB- |
denotes |
] |
T20847 |
806-807 |
. |
denotes |
. |
T20848 |
807-923 |
sentence |
denotes |
In situ hybridization and RT-PCR showed significant reduction of mr-s signal in the Crx KO retina and pineal gland. |
T20849 |
808-810 |
FW |
denotes |
In |
T20850 |
811-815 |
FW |
denotes |
situ |
T20851 |
816-829 |
NN |
denotes |
hybridization |
T20852 |
841-847 |
VBD |
denotes |
showed |
T20853 |
830-833 |
CC |
denotes |
and |
T20854 |
834-836 |
NN |
denotes |
RT |
T20855 |
837-840 |
NN |
denotes |
PCR |
T20856 |
836-837 |
HYPH |
denotes |
- |
T20857 |
848-859 |
JJ |
denotes |
significant |
T20858 |
860-869 |
NN |
denotes |
reduction |
T20859 |
870-872 |
IN |
denotes |
of |
T20860 |
873-875 |
NN |
denotes |
mr |
T20861 |
876-877 |
NN |
denotes |
s |
T20862 |
875-876 |
HYPH |
denotes |
- |
T20863 |
878-884 |
NN |
denotes |
signal |
T20864 |
885-887 |
IN |
denotes |
in |
T20865 |
888-891 |
DT |
denotes |
the |
T20866 |
896-898 |
NN |
denotes |
KO |
T20867 |
892-895 |
NN |
denotes |
Crx |
T20868 |
899-905 |
NN |
denotes |
retina |
T20869 |
906-909 |
CC |
denotes |
and |
T20870 |
910-916 |
JJ |
denotes |
pineal |
T20871 |
917-922 |
NN |
denotes |
gland |
T20872 |
922-923 |
. |
denotes |
. |
T20873 |
923-1058 |
sentence |
denotes |
Furthermore, the luciferase assay demonstrated that Otx2 and Crx may directly upregulate the transcription of mr-s in mammalian cells. |
T20874 |
924-935 |
RB |
denotes |
Furthermore |
T20875 |
958-970 |
VBD |
denotes |
demonstrated |
T20876 |
935-937 |
, |
denotes |
, |
T20877 |
937-940 |
DT |
denotes |
the |
T20878 |
952-957 |
NN |
denotes |
assay |
T20879 |
941-951 |
NN |
denotes |
luciferase |
T20880 |
971-975 |
IN |
denotes |
that |
T20881 |
1002-1012 |
VB |
denotes |
upregulate |
T20882 |
976-980 |
NN |
denotes |
Otx2 |
T20883 |
981-984 |
CC |
denotes |
and |
T20884 |
985-988 |
NN |
denotes |
Crx |
T20885 |
989-992 |
MD |
denotes |
may |
T20886 |
993-1001 |
RB |
denotes |
directly |
T20887 |
1013-1016 |
DT |
denotes |
the |
T20888 |
1017-1030 |
NN |
denotes |
transcription |
T20889 |
1031-1033 |
IN |
denotes |
of |
T20890 |
1034-1036 |
NN |
denotes |
mr |
T20891 |
1037-1038 |
NN |
denotes |
s |
T20892 |
1036-1037 |
HYPH |
denotes |
- |
T20893 |
1039-1041 |
IN |
denotes |
in |
T20894 |
1042-1051 |
JJ |
denotes |
mammalian |
T20895 |
1052-1057 |
NNS |
denotes |
cells |
T20896 |
1057-1058 |
. |
denotes |
. |
T20897 |
1058-1205 |
sentence |
denotes |
In retinal photoreceptor cells, the Otx2 transcripts are not highly expressed at P6-P9, while the Crx transcripts are strongly detected around P6. |
T20898 |
1059-1061 |
IN |
denotes |
In |
T20899 |
1112-1115 |
VBP |
denotes |
are |
T20900 |
1062-1069 |
JJ |
denotes |
retinal |
T20901 |
1084-1089 |
NNS |
denotes |
cells |
T20902 |
1070-1083 |
NN |
denotes |
photoreceptor |
T20903 |
1089-1091 |
, |
denotes |
, |
T20904 |
1091-1094 |
DT |
denotes |
the |
T20905 |
1100-1111 |
NNS |
denotes |
transcripts |
T20906 |
1095-1099 |
NN |
denotes |
Otx2 |
T20907 |
1116-1119 |
RB |
denotes |
not |
T20908 |
1120-1126 |
RB |
denotes |
highly |
T20909 |
1127-1136 |
JJ |
denotes |
expressed |
T20910 |
1137-1139 |
IN |
denotes |
at |
T20911 |
1140-1142 |
NN |
denotes |
P6 |
T20912 |
1142-1143 |
SYM |
denotes |
- |
T20913 |
1143-1145 |
NN |
denotes |
P9 |
T20914 |
1145-1147 |
, |
denotes |
, |
T20915 |
1147-1152 |
IN |
denotes |
while |
T20916 |
1186-1194 |
VBN |
denotes |
detected |
T20917 |
1153-1156 |
DT |
denotes |
the |
T20918 |
1161-1172 |
NNS |
denotes |
transcripts |
T20919 |
1157-1160 |
NN |
denotes |
Crx |
T20920 |
1173-1176 |
VBP |
denotes |
are |
T20921 |
1177-1185 |
RB |
denotes |
strongly |
T20922 |
1195-1201 |
IN |
denotes |
around |
T20923 |
1202-1204 |
NN |
denotes |
P6 |
T20924 |
1204-1205 |
. |
denotes |
. |
T20925 |
1205-1299 |
sentence |
denotes |
Therefore, our results strongly suggest that mr-s transcription is directly regulated by Crx. |
T20926 |
1206-1215 |
RB |
denotes |
Therefore |
T20927 |
1238-1245 |
VBP |
denotes |
suggest |
T20928 |
1215-1217 |
, |
denotes |
, |
T20929 |
1217-1220 |
PRP$ |
denotes |
our |
T20930 |
1221-1228 |
NNS |
denotes |
results |
T20931 |
1229-1237 |
RB |
denotes |
strongly |
T20932 |
1246-1250 |
IN |
denotes |
that |
T20933 |
1282-1291 |
VBN |
denotes |
regulated |
T20934 |
1251-1253 |
NN |
denotes |
mr |
T20935 |
1254-1255 |
NN |
denotes |
s |
T20936 |
1253-1254 |
HYPH |
denotes |
- |
T20937 |
1256-1269 |
NN |
denotes |
transcription |
T20938 |
1270-1272 |
VBZ |
denotes |
is |
T20939 |
1273-1281 |
RB |
denotes |
directly |
T20940 |
1292-1294 |
IN |
denotes |
by |
T20941 |
1295-1298 |
NN |
denotes |
Crx |
T20942 |
1298-1299 |
. |
denotes |
. |
T20943 |
1299-1481 |
sentence |
denotes |
In the present study, Nrl, a photoreceptor-specific transcription factor that is highly expressed in photoreceptors at the postnatal stage, did not affect the transcription of mr-s. |
T20944 |
1300-1302 |
IN |
denotes |
In |
T20945 |
1448-1454 |
VB |
denotes |
affect |
T20946 |
1303-1306 |
DT |
denotes |
the |
T20947 |
1315-1320 |
NN |
denotes |
study |
T20948 |
1307-1314 |
JJ |
denotes |
present |
T20949 |
1320-1322 |
, |
denotes |
, |
T20950 |
1322-1325 |
NN |
denotes |
Nrl |
T20951 |
1325-1327 |
, |
denotes |
, |
T20952 |
1327-1328 |
DT |
denotes |
a |
T20953 |
1366-1372 |
NN |
denotes |
factor |
T20954 |
1329-1342 |
NN |
denotes |
photoreceptor |
T20955 |
1343-1351 |
JJ |
denotes |
specific |
T20956 |
1342-1343 |
HYPH |
denotes |
- |
T20957 |
1352-1365 |
NN |
denotes |
transcription |
T20958 |
1373-1377 |
WDT |
denotes |
that |
T20959 |
1388-1397 |
VBN |
denotes |
expressed |
T20960 |
1378-1380 |
VBZ |
denotes |
is |
T20961 |
1381-1387 |
RB |
denotes |
highly |
T20962 |
1398-1400 |
IN |
denotes |
in |
T20963 |
1401-1415 |
NNS |
denotes |
photoreceptors |
T20964 |
1416-1418 |
IN |
denotes |
at |
T20965 |
1419-1422 |
DT |
denotes |
the |
T20966 |
1433-1438 |
NN |
denotes |
stage |
T20967 |
1423-1432 |
JJ |
denotes |
postnatal |
T20968 |
1438-1440 |
, |
denotes |
, |
T20969 |
1440-1443 |
VBD |
denotes |
did |
T20970 |
1444-1447 |
RB |
denotes |
not |
T20971 |
1455-1458 |
DT |
denotes |
the |
T20972 |
1459-1472 |
NN |
denotes |
transcription |
T20973 |
1473-1475 |
IN |
denotes |
of |
T20974 |
1476-1478 |
NN |
denotes |
mr |
T20975 |
1479-1480 |
NN |
denotes |
s |
T20976 |
1478-1479 |
HYPH |
denotes |
- |
T20977 |
1480-1481 |
. |
denotes |
. |
T20978 |
1481-1589 |
sentence |
denotes |
This finding is actually consistent with the analysis of the Nrl KO mouse which was recently reported [40]. |
T20979 |
1482-1486 |
DT |
denotes |
This |
T20980 |
1487-1494 |
NN |
denotes |
finding |
T20981 |
1495-1497 |
VBZ |
denotes |
is |
T20982 |
1498-1506 |
RB |
denotes |
actually |
T20983 |
1507-1517 |
JJ |
denotes |
consistent |
T20984 |
1518-1522 |
IN |
denotes |
with |
T20985 |
1523-1526 |
DT |
denotes |
the |
T20986 |
1527-1535 |
NN |
denotes |
analysis |
T20987 |
1536-1538 |
IN |
denotes |
of |
T20988 |
1539-1542 |
DT |
denotes |
the |
T20989 |
1550-1555 |
NN |
denotes |
mouse |
T20990 |
1543-1546 |
NN |
denotes |
Nrl |
T20991 |
1547-1549 |
NN |
denotes |
KO |
T20992 |
1556-1561 |
WDT |
denotes |
which |
T20993 |
1575-1583 |
VBN |
denotes |
reported |
T20994 |
1562-1565 |
VBD |
denotes |
was |
T20995 |
1566-1574 |
RB |
denotes |
recently |
T20996 |
1584-1585 |
-LRB- |
denotes |
[ |
T20997 |
1585-1587 |
CD |
denotes |
40 |
T20998 |
1587-1588 |
-RRB- |
denotes |
] |
T20999 |
1588-1589 |
. |
denotes |
. |
T21000 |
1589-1769 |
sentence |
denotes |
The expression profiles of wild-type and Nrl KO retinas at P2, P10 and 2 months were analyzed and mr-s was not included in 161 differentially expressed genes in the Nrl KO retina. |
T21001 |
1590-1593 |
DT |
denotes |
The |
T21002 |
1605-1613 |
NNS |
denotes |
profiles |
T21003 |
1594-1604 |
NN |
denotes |
expression |
T21004 |
1675-1683 |
VBN |
denotes |
analyzed |
T21005 |
1614-1616 |
IN |
denotes |
of |
T21006 |
1617-1621 |
JJ |
denotes |
wild |
T21007 |
1622-1626 |
NN |
denotes |
type |
T21008 |
1621-1622 |
HYPH |
denotes |
- |
T21009 |
1638-1645 |
NNS |
denotes |
retinas |
T21010 |
1627-1630 |
CC |
denotes |
and |
T21011 |
1631-1634 |
NN |
denotes |
Nrl |
T21012 |
1635-1637 |
NN |
denotes |
KO |
T21013 |
1646-1648 |
IN |
denotes |
at |
T21014 |
1649-1651 |
NN |
denotes |
P2 |
T21015 |
1651-1653 |
, |
denotes |
, |
T21016 |
1653-1656 |
NN |
denotes |
P10 |
T21017 |
1657-1660 |
CC |
denotes |
and |
T21018 |
1661-1662 |
CD |
denotes |
2 |
T21019 |
1663-1669 |
NNS |
denotes |
months |
T21020 |
1670-1674 |
VBD |
denotes |
were |
T21021 |
1684-1687 |
CC |
denotes |
and |
T21022 |
1688-1690 |
NN |
denotes |
mr |
T21023 |
1691-1692 |
NN |
denotes |
s |
T21024 |
1690-1691 |
HYPH |
denotes |
- |
T21025 |
1701-1709 |
VBN |
denotes |
included |
T21026 |
1693-1696 |
VBD |
denotes |
was |
T21027 |
1697-1700 |
RB |
denotes |
not |
T21028 |
1710-1712 |
IN |
denotes |
in |
T21029 |
1713-1716 |
CD |
denotes |
161 |
T21030 |
1742-1747 |
NNS |
denotes |
genes |
T21031 |
1717-1731 |
RB |
denotes |
differentially |
T21032 |
1732-1741 |
VBN |
denotes |
expressed |
T21033 |
1748-1750 |
IN |
denotes |
in |
T21034 |
1751-1754 |
DT |
denotes |
the |
T21035 |
1762-1768 |
NN |
denotes |
retina |
T21036 |
1755-1758 |
NN |
denotes |
Nrl |
T21037 |
1759-1761 |
NN |
denotes |
KO |
T21038 |
1768-1769 |
. |
denotes |
. |
T21039 |
1769-1857 |
sentence |
denotes |
Previous reports suggested that the SAM domain is a protein-protein interaction module. |
T21040 |
1770-1778 |
JJ |
denotes |
Previous |
T21041 |
1779-1786 |
NNS |
denotes |
reports |
T21042 |
1787-1796 |
VBD |
denotes |
suggested |
T21043 |
1797-1801 |
IN |
denotes |
that |
T21044 |
1817-1819 |
VBZ |
denotes |
is |
T21045 |
1802-1805 |
DT |
denotes |
the |
T21046 |
1810-1816 |
NN |
denotes |
domain |
T21047 |
1806-1809 |
NN |
denotes |
SAM |
T21048 |
1820-1821 |
DT |
denotes |
a |
T21049 |
1850-1856 |
NN |
denotes |
module |
T21050 |
1822-1829 |
NN |
denotes |
protein |
T21051 |
1830-1837 |
NN |
denotes |
protein |
T21052 |
1829-1830 |
HYPH |
denotes |
- |
T21053 |
1838-1849 |
NN |
denotes |
interaction |
T21054 |
1856-1857 |
. |
denotes |
. |
T21055 |
1857-2070 |
sentence |
denotes |
The SAM domain of the mr-s protein is closely related to that of ph and TEL, whose SAM domains can form a helical, head-to-tail polymeric structure and mediate the formation of a higher order chromatin structure. |
T21056 |
1858-1861 |
DT |
denotes |
The |
T21057 |
1866-1872 |
NN |
denotes |
domain |
T21058 |
1862-1865 |
NN |
denotes |
SAM |
T21059 |
1904-1911 |
VBN |
denotes |
related |
T21060 |
1873-1875 |
IN |
denotes |
of |
T21061 |
1876-1879 |
DT |
denotes |
the |
T21062 |
1885-1892 |
NN |
denotes |
protein |
T21063 |
1880-1882 |
NN |
denotes |
mr |
T21064 |
1883-1884 |
NN |
denotes |
s |
T21065 |
1882-1883 |
HYPH |
denotes |
- |
T21066 |
1893-1895 |
VBZ |
denotes |
is |
T21067 |
1896-1903 |
RB |
denotes |
closely |
T21068 |
1912-1914 |
IN |
denotes |
to |
T21069 |
1915-1919 |
DT |
denotes |
that |
T21070 |
1920-1922 |
IN |
denotes |
of |
T21071 |
1923-1925 |
NN |
denotes |
ph |
T21072 |
1926-1929 |
CC |
denotes |
and |
T21073 |
1930-1933 |
NN |
denotes |
TEL |
T21074 |
1933-1935 |
, |
denotes |
, |
T21075 |
1935-1940 |
WP$ |
denotes |
whose |
T21076 |
1945-1952 |
NNS |
denotes |
domains |
T21077 |
1941-1944 |
NN |
denotes |
SAM |
T21078 |
1957-1961 |
VB |
denotes |
form |
T21079 |
1953-1956 |
MD |
denotes |
can |
T21080 |
1962-1963 |
DT |
denotes |
a |
T21081 |
1996-2005 |
NN |
denotes |
structure |
T21082 |
1964-1971 |
JJ |
denotes |
helical |
T21083 |
1971-1973 |
, |
denotes |
, |
T21084 |
1973-1977 |
NN |
denotes |
head |
T21085 |
1977-1978 |
HYPH |
denotes |
- |
T21086 |
1978-1980 |
IN |
denotes |
to |
T21087 |
1980-1981 |
HYPH |
denotes |
- |
T21088 |
1981-1985 |
NN |
denotes |
tail |
T21089 |
1986-1995 |
JJ |
denotes |
polymeric |
T21090 |
2006-2009 |
CC |
denotes |
and |
T21091 |
2010-2017 |
VB |
denotes |
mediate |
T21092 |
2018-2021 |
DT |
denotes |
the |
T21093 |
2022-2031 |
NN |
denotes |
formation |
T21094 |
2032-2034 |
IN |
denotes |
of |
T21095 |
2035-2036 |
DT |
denotes |
a |
T21096 |
2060-2069 |
NN |
denotes |
structure |
T21097 |
2037-2043 |
JJR |
denotes |
higher |
T21098 |
2044-2049 |
NN |
denotes |
order |
T21099 |
2050-2059 |
NN |
denotes |
chromatin |
T21100 |
2069-2070 |
. |
denotes |
. |
T21101 |
2070-2196 |
sentence |
denotes |
To characterize the biochemical function of mr-s, we performed yeast two-hybrid screening using full-length mr-s as the bait. |
T21102 |
2071-2073 |
TO |
denotes |
To |
T21103 |
2074-2086 |
VB |
denotes |
characterize |
T21104 |
2124-2133 |
VBD |
denotes |
performed |
T21105 |
2087-2090 |
DT |
denotes |
the |
T21106 |
2103-2111 |
NN |
denotes |
function |
T21107 |
2091-2102 |
JJ |
denotes |
biochemical |
T21108 |
2112-2114 |
IN |
denotes |
of |
T21109 |
2115-2117 |
NN |
denotes |
mr |
T21110 |
2118-2119 |
NN |
denotes |
s |
T21111 |
2117-2118 |
HYPH |
denotes |
- |
T21112 |
2119-2121 |
, |
denotes |
, |
T21113 |
2121-2123 |
PRP |
denotes |
we |
T21114 |
2134-2139 |
NN |
denotes |
yeast |
T21115 |
2151-2160 |
NN |
denotes |
screening |
T21116 |
2140-2143 |
CD |
denotes |
two |
T21117 |
2144-2150 |
NN |
denotes |
hybrid |
T21118 |
2143-2144 |
HYPH |
denotes |
- |
T21119 |
2161-2166 |
VBG |
denotes |
using |
T21120 |
2167-2171 |
JJ |
denotes |
full |
T21121 |
2172-2178 |
NN |
denotes |
length |
T21122 |
2171-2172 |
HYPH |
denotes |
- |
T21123 |
2182-2183 |
NN |
denotes |
s |
T21124 |
2179-2181 |
NN |
denotes |
mr |
T21125 |
2181-2182 |
HYPH |
denotes |
- |
T21126 |
2184-2186 |
IN |
denotes |
as |
T21127 |
2187-2190 |
DT |
denotes |
the |
T21128 |
2191-2195 |
NN |
denotes |
bait |
T21129 |
2195-2196 |
. |
denotes |
. |
T21130 |
2196-2326 |
sentence |
denotes |
As a result, the most frequent positive clones (5/28) in the screening were the cDNA fragments containing the SAM domain of mr-s. |
T21131 |
2197-2199 |
IN |
denotes |
As |
T21132 |
2268-2272 |
VBD |
denotes |
were |
T21133 |
2200-2201 |
DT |
denotes |
a |
T21134 |
2202-2208 |
NN |
denotes |
result |
T21135 |
2208-2210 |
, |
denotes |
, |
T21136 |
2210-2213 |
DT |
denotes |
the |
T21137 |
2237-2243 |
NNS |
denotes |
clones |
T21138 |
2214-2218 |
RBS |
denotes |
most |
T21139 |
2219-2227 |
JJ |
denotes |
frequent |
T21140 |
2228-2236 |
JJ |
denotes |
positive |
T21141 |
2244-2245 |
-LRB- |
denotes |
( |
T21142 |
2245-2246 |
CD |
denotes |
5 |
T21143 |
2246-2247 |
SYM |
denotes |
/ |
T21144 |
2247-2249 |
CD |
denotes |
28 |
T21145 |
2249-2250 |
-RRB- |
denotes |
) |
T21146 |
2251-2253 |
IN |
denotes |
in |
T21147 |
2254-2257 |
DT |
denotes |
the |
T21148 |
2258-2267 |
NN |
denotes |
screening |
T21149 |
2273-2276 |
DT |
denotes |
the |
T21150 |
2282-2291 |
NNS |
denotes |
fragments |
T21151 |
2277-2281 |
NN |
denotes |
cDNA |
T21152 |
2292-2302 |
VBG |
denotes |
containing |
T21153 |
2303-2306 |
DT |
denotes |
the |
T21154 |
2311-2317 |
NN |
denotes |
domain |
T21155 |
2307-2310 |
NN |
denotes |
SAM |
T21156 |
2318-2320 |
IN |
denotes |
of |
T21157 |
2321-2323 |
NN |
denotes |
mr |
T21158 |
2324-2325 |
NN |
denotes |
s |
T21159 |
2323-2324 |
HYPH |
denotes |
- |
T21160 |
2325-2326 |
. |
denotes |
. |
T21161 |
2326-2399 |
sentence |
denotes |
This strongly suggests that mr-s self-associates through its SAM domain. |
T21162 |
2327-2331 |
DT |
denotes |
This |
T21163 |
2341-2349 |
VBZ |
denotes |
suggests |
T21164 |
2332-2340 |
RB |
denotes |
strongly |
T21165 |
2350-2354 |
IN |
denotes |
that |
T21166 |
2365-2375 |
VBZ |
denotes |
associates |
T21167 |
2355-2357 |
NN |
denotes |
mr |
T21168 |
2358-2359 |
NN |
denotes |
s |
T21169 |
2357-2358 |
HYPH |
denotes |
- |
T21170 |
2360-2364 |
NN |
denotes |
self |
T21171 |
2364-2365 |
HYPH |
denotes |
- |
T21172 |
2376-2383 |
IN |
denotes |
through |
T21173 |
2384-2387 |
PRP$ |
denotes |
its |
T21174 |
2392-2398 |
NN |
denotes |
domain |
T21175 |
2388-2391 |
NN |
denotes |
SAM |
T21176 |
2398-2399 |
. |
denotes |
. |
T21177 |
2399-2585 |
sentence |
denotes |
An immunoprecipitation assay, using two site-directed mutants of the SAM domain of mr-s, demonstrated that the mr-s protein can self-associate through its SAM domain in mammalian cells. |
T21178 |
2400-2402 |
DT |
denotes |
An |
T21179 |
2423-2428 |
NN |
denotes |
assay |
T21180 |
2403-2422 |
NN |
denotes |
immunoprecipitation |
T21181 |
2489-2501 |
VBD |
denotes |
demonstrated |
T21182 |
2428-2430 |
, |
denotes |
, |
T21183 |
2430-2435 |
VBG |
denotes |
using |
T21184 |
2436-2439 |
CD |
denotes |
two |
T21185 |
2454-2461 |
NNS |
denotes |
mutants |
T21186 |
2440-2444 |
NN |
denotes |
site |
T21187 |
2445-2453 |
VBN |
denotes |
directed |
T21188 |
2444-2445 |
HYPH |
denotes |
- |
T21189 |
2462-2464 |
IN |
denotes |
of |
T21190 |
2465-2468 |
DT |
denotes |
the |
T21191 |
2473-2479 |
NN |
denotes |
domain |
T21192 |
2469-2472 |
NN |
denotes |
SAM |
T21193 |
2480-2482 |
IN |
denotes |
of |
T21194 |
2483-2485 |
NN |
denotes |
mr |
T21195 |
2486-2487 |
NN |
denotes |
s |
T21196 |
2485-2486 |
HYPH |
denotes |
- |
T21197 |
2487-2489 |
, |
denotes |
, |
T21198 |
2502-2506 |
IN |
denotes |
that |
T21199 |
2533-2542 |
VB |
denotes |
associate |
T21200 |
2507-2510 |
DT |
denotes |
the |
T21201 |
2516-2523 |
NN |
denotes |
protein |
T21202 |
2511-2513 |
NN |
denotes |
mr |
T21203 |
2514-2515 |
NN |
denotes |
s |
T21204 |
2513-2514 |
HYPH |
denotes |
- |
T21205 |
2524-2527 |
MD |
denotes |
can |
T21206 |
2528-2532 |
NN |
denotes |
self |
T21207 |
2532-2533 |
HYPH |
denotes |
- |
T21208 |
2543-2550 |
IN |
denotes |
through |
T21209 |
2551-2554 |
PRP$ |
denotes |
its |
T21210 |
2559-2565 |
NN |
denotes |
domain |
T21211 |
2555-2558 |
NN |
denotes |
SAM |
T21212 |
2566-2568 |
IN |
denotes |
in |
T21213 |
2569-2578 |
JJ |
denotes |
mammalian |
T21214 |
2579-2584 |
NNS |
denotes |
cells |
T21215 |
2584-2585 |
. |
denotes |
. |
T21216 |
2585-2950 |
sentence |
denotes |
While we did not address the question whether the SAM domain of mr-s forms a polymeric structure in the present study, the phylogenetic analysis of SAM domain of mr-s and other SAM domain-containing molecules suggests that mr-s can form head-to-tail polymer and mediate gene silencing by spreading repressive complexes along the chromatin similar to ph and/or TEL. |
T21217 |
2586-2591 |
IN |
denotes |
While |
T21218 |
2603-2610 |
VB |
denotes |
address |
T21219 |
2592-2594 |
PRP |
denotes |
we |
T21220 |
2595-2598 |
VBD |
denotes |
did |
T21221 |
2599-2602 |
RB |
denotes |
not |
T21222 |
2795-2803 |
VBZ |
denotes |
suggests |
T21223 |
2611-2614 |
DT |
denotes |
the |
T21224 |
2615-2623 |
NN |
denotes |
question |
T21225 |
2624-2631 |
IN |
denotes |
whether |
T21226 |
2655-2660 |
VBZ |
denotes |
forms |
T21227 |
2632-2635 |
DT |
denotes |
the |
T21228 |
2640-2646 |
NN |
denotes |
domain |
T21229 |
2636-2639 |
NN |
denotes |
SAM |
T21230 |
2647-2649 |
IN |
denotes |
of |
T21231 |
2650-2652 |
NN |
denotes |
mr |
T21232 |
2653-2654 |
NN |
denotes |
s |
T21233 |
2652-2653 |
HYPH |
denotes |
- |
T21234 |
2661-2662 |
DT |
denotes |
a |
T21235 |
2673-2682 |
NN |
denotes |
structure |
T21236 |
2663-2672 |
JJ |
denotes |
polymeric |
T21237 |
2683-2685 |
IN |
denotes |
in |
T21238 |
2686-2689 |
DT |
denotes |
the |
T21239 |
2698-2703 |
NN |
denotes |
study |
T21240 |
2690-2697 |
JJ |
denotes |
present |
T21241 |
2703-2705 |
, |
denotes |
, |
T21242 |
2705-2708 |
DT |
denotes |
the |
T21243 |
2722-2730 |
NN |
denotes |
analysis |
T21244 |
2709-2721 |
JJ |
denotes |
phylogenetic |
T21245 |
2731-2733 |
IN |
denotes |
of |
T21246 |
2734-2737 |
NN |
denotes |
SAM |
T21247 |
2738-2744 |
NN |
denotes |
domain |
T21248 |
2745-2747 |
IN |
denotes |
of |
T21249 |
2748-2750 |
NN |
denotes |
mr |
T21250 |
2751-2752 |
NN |
denotes |
s |
T21251 |
2750-2751 |
HYPH |
denotes |
- |
T21252 |
2753-2756 |
CC |
denotes |
and |
T21253 |
2757-2762 |
JJ |
denotes |
other |
T21254 |
2785-2794 |
NNS |
denotes |
molecules |
T21255 |
2763-2766 |
NN |
denotes |
SAM |
T21256 |
2767-2773 |
NN |
denotes |
domain |
T21257 |
2774-2784 |
VBG |
denotes |
containing |
T21258 |
2773-2774 |
HYPH |
denotes |
- |
T21259 |
2804-2808 |
IN |
denotes |
that |
T21260 |
2818-2822 |
VB |
denotes |
form |
T21261 |
2809-2811 |
NN |
denotes |
mr |
T21262 |
2812-2813 |
NN |
denotes |
s |
T21263 |
2811-2812 |
HYPH |
denotes |
- |
T21264 |
2814-2817 |
MD |
denotes |
can |
T21265 |
2823-2827 |
NN |
denotes |
head |
T21266 |
2836-2843 |
NN |
denotes |
polymer |
T21267 |
2827-2828 |
HYPH |
denotes |
- |
T21268 |
2828-2830 |
IN |
denotes |
to |
T21269 |
2830-2831 |
HYPH |
denotes |
- |
T21270 |
2831-2835 |
NN |
denotes |
tail |
T21271 |
2844-2847 |
CC |
denotes |
and |
T21272 |
2848-2855 |
VBP |
denotes |
mediate |
T21273 |
2856-2860 |
NN |
denotes |
gene |
T21274 |
2861-2870 |
NN |
denotes |
silencing |
T21275 |
2871-2873 |
IN |
denotes |
by |
T21276 |
2874-2883 |
VBG |
denotes |
spreading |
T21277 |
2884-2894 |
JJ |
denotes |
repressive |
T21278 |
2895-2904 |
NNS |
denotes |
complexes |
T21279 |
2905-2910 |
IN |
denotes |
along |
T21280 |
2911-2914 |
DT |
denotes |
the |
T21281 |
2915-2924 |
NN |
denotes |
chromatin |
T21282 |
2925-2932 |
JJ |
denotes |
similar |
T21283 |
2933-2935 |
IN |
denotes |
to |
T21284 |
2936-2938 |
NN |
denotes |
ph |
T21285 |
2939-2942 |
CC |
denotes |
and |
T21286 |
2942-2943 |
HYPH |
denotes |
/ |
T21287 |
2943-2945 |
CC |
denotes |
or |
T21288 |
2946-2949 |
NN |
denotes |
TEL |
T21289 |
2949-2950 |
. |
denotes |
. |
T21290 |
2950-3163 |
sentence |
denotes |
Although our results in the immunoprecipitation assay demonstrated that the N-terminal constructs lacking a SAM domain still interact with each other, these results do not fit into the head-to-tail polymer model. |
T21291 |
2951-2959 |
IN |
denotes |
Although |
T21292 |
3005-3017 |
VBD |
denotes |
demonstrated |
T21293 |
2960-2963 |
PRP$ |
denotes |
our |
T21294 |
2964-2971 |
NNS |
denotes |
results |
T21295 |
2972-2974 |
IN |
denotes |
in |
T21296 |
2975-2978 |
DT |
denotes |
the |
T21297 |
2999-3004 |
NN |
denotes |
assay |
T21298 |
2979-2998 |
NN |
denotes |
immunoprecipitation |
T21299 |
3123-3126 |
VB |
denotes |
fit |
T21300 |
3018-3022 |
IN |
denotes |
that |
T21301 |
3076-3084 |
VBP |
denotes |
interact |
T21302 |
3023-3026 |
DT |
denotes |
the |
T21303 |
3038-3048 |
NNS |
denotes |
constructs |
T21304 |
3027-3028 |
NN |
denotes |
N |
T21305 |
3029-3037 |
JJ |
denotes |
terminal |
T21306 |
3028-3029 |
HYPH |
denotes |
- |
T21307 |
3049-3056 |
VBG |
denotes |
lacking |
T21308 |
3057-3058 |
DT |
denotes |
a |
T21309 |
3063-3069 |
NN |
denotes |
domain |
T21310 |
3059-3062 |
NN |
denotes |
SAM |
T21311 |
3070-3075 |
RB |
denotes |
still |
T21312 |
3085-3089 |
IN |
denotes |
with |
T21313 |
3090-3094 |
DT |
denotes |
each |
T21314 |
3095-3100 |
JJ |
denotes |
other |
T21315 |
3100-3102 |
, |
denotes |
, |
T21316 |
3102-3107 |
DT |
denotes |
these |
T21317 |
3108-3115 |
NNS |
denotes |
results |
T21318 |
3116-3118 |
VBP |
denotes |
do |
T21319 |
3119-3122 |
RB |
denotes |
not |
T21320 |
3127-3131 |
IN |
denotes |
into |
T21321 |
3132-3135 |
DT |
denotes |
the |
T21322 |
3157-3162 |
NN |
denotes |
model |
T21323 |
3136-3140 |
NN |
denotes |
head |
T21324 |
3140-3141 |
HYPH |
denotes |
- |
T21325 |
3141-3143 |
IN |
denotes |
to |
T21326 |
3143-3144 |
HYPH |
denotes |
- |
T21327 |
3144-3148 |
NN |
denotes |
tail |
T21328 |
3149-3156 |
NN |
denotes |
polymer |
T21329 |
3162-3163 |
. |
denotes |
. |
T21330 |
3163-3301 |
sentence |
denotes |
We cannot exclude the possibility that the resulting protein-protein interaction of mr-s is an artifact of the overexpression conditions. |
T21331 |
3164-3166 |
PRP |
denotes |
We |
T21332 |
3174-3181 |
VB |
denotes |
exclude |
T21333 |
3167-3170 |
MD |
denotes |
can |
T21334 |
3170-3173 |
RB |
denotes |
not |
T21335 |
3182-3185 |
DT |
denotes |
the |
T21336 |
3186-3197 |
NN |
denotes |
possibility |
T21337 |
3198-3202 |
IN |
denotes |
that |
T21338 |
3253-3255 |
VBZ |
denotes |
is |
T21339 |
3203-3206 |
DT |
denotes |
the |
T21340 |
3233-3244 |
NN |
denotes |
interaction |
T21341 |
3207-3216 |
VBG |
denotes |
resulting |
T21342 |
3217-3224 |
NN |
denotes |
protein |
T21343 |
3225-3232 |
NN |
denotes |
protein |
T21344 |
3224-3225 |
HYPH |
denotes |
- |
T21345 |
3245-3247 |
IN |
denotes |
of |
T21346 |
3248-3250 |
NN |
denotes |
mr |
T21347 |
3251-3252 |
NN |
denotes |
s |
T21348 |
3250-3251 |
HYPH |
denotes |
- |
T21349 |
3256-3258 |
DT |
denotes |
an |
T21350 |
3259-3267 |
NN |
denotes |
artifact |
T21351 |
3268-3270 |
IN |
denotes |
of |
T21352 |
3271-3274 |
DT |
denotes |
the |
T21353 |
3290-3300 |
NNS |
denotes |
conditions |
T21354 |
3275-3289 |
NN |
denotes |
overexpression |
T21355 |
3300-3301 |
. |
denotes |
. |
T21356 |
3301-3374 |
sentence |
denotes |
The issue of whether or not mr-s forms a polymer awaits future analysis. |
T21357 |
3302-3305 |
DT |
denotes |
The |
T21358 |
3306-3311 |
NN |
denotes |
issue |
T21359 |
3351-3357 |
VBZ |
denotes |
awaits |
T21360 |
3312-3314 |
IN |
denotes |
of |
T21361 |
3315-3322 |
IN |
denotes |
whether |
T21362 |
3335-3340 |
VBZ |
denotes |
forms |
T21363 |
3323-3325 |
CC |
denotes |
or |
T21364 |
3326-3329 |
RB |
denotes |
not |
T21365 |
3330-3332 |
NN |
denotes |
mr |
T21366 |
3333-3334 |
NN |
denotes |
s |
T21367 |
3332-3333 |
HYPH |
denotes |
- |
T21368 |
3341-3342 |
DT |
denotes |
a |
T21369 |
3343-3350 |
NN |
denotes |
polymer |
T21370 |
3358-3364 |
JJ |
denotes |
future |
T21371 |
3365-3373 |
NN |
denotes |
analysis |
T21372 |
3373-3374 |
. |
denotes |
. |
T21373 |
3374-3536 |
sentence |
denotes |
A previous report indicated that TEL contains a sequence-specific DNA binding domain, namely the ETS domain, and binds to specific sites via its ETS domain [41]. |
T21374 |
3375-3376 |
DT |
denotes |
A |
T21375 |
3386-3392 |
NN |
denotes |
report |
T21376 |
3377-3385 |
JJ |
denotes |
previous |
T21377 |
3393-3402 |
VBD |
denotes |
indicated |
T21378 |
3403-3407 |
IN |
denotes |
that |
T21379 |
3412-3420 |
VBZ |
denotes |
contains |
T21380 |
3408-3411 |
NN |
denotes |
TEL |
T21381 |
3421-3422 |
DT |
denotes |
a |
T21382 |
3453-3459 |
NN |
denotes |
domain |
T21383 |
3423-3431 |
NN |
denotes |
sequence |
T21384 |
3432-3440 |
JJ |
denotes |
specific |
T21385 |
3431-3432 |
HYPH |
denotes |
- |
T21386 |
3441-3444 |
NN |
denotes |
DNA |
T21387 |
3445-3452 |
VBG |
denotes |
binding |
T21388 |
3459-3461 |
, |
denotes |
, |
T21389 |
3476-3482 |
NN |
denotes |
domain |
T21390 |
3461-3467 |
RB |
denotes |
namely |
T21391 |
3468-3471 |
DT |
denotes |
the |
T21392 |
3472-3475 |
NN |
denotes |
ETS |
T21393 |
3482-3484 |
, |
denotes |
, |
T21394 |
3484-3487 |
CC |
denotes |
and |
T21395 |
3488-3493 |
VBZ |
denotes |
binds |
T21396 |
3494-3496 |
IN |
denotes |
to |
T21397 |
3497-3505 |
JJ |
denotes |
specific |
T21398 |
3506-3511 |
NNS |
denotes |
sites |
T21399 |
3512-3515 |
IN |
denotes |
via |
T21400 |
3516-3519 |
PRP$ |
denotes |
its |
T21401 |
3524-3530 |
NN |
denotes |
domain |
T21402 |
3520-3523 |
NN |
denotes |
ETS |
T21403 |
3531-3532 |
-LRB- |
denotes |
[ |
T21404 |
3532-3534 |
CD |
denotes |
41 |
T21405 |
3534-3535 |
-RRB- |
denotes |
] |
T21406 |
3535-3536 |
. |
denotes |
. |
T21407 |
3536-3632 |
sentence |
denotes |
TEL could serve to nucleate a polymer, which would spread by oligomerization of the SAM domain. |
T21408 |
3537-3540 |
NN |
denotes |
TEL |
T21409 |
3547-3552 |
VB |
denotes |
serve |
T21410 |
3541-3546 |
MD |
denotes |
could |
T21411 |
3553-3555 |
TO |
denotes |
to |
T21412 |
3556-3564 |
VB |
denotes |
nucleate |
T21413 |
3565-3566 |
DT |
denotes |
a |
T21414 |
3567-3574 |
NN |
denotes |
polymer |
T21415 |
3574-3576 |
, |
denotes |
, |
T21416 |
3576-3581 |
WDT |
denotes |
which |
T21417 |
3588-3594 |
VB |
denotes |
spread |
T21418 |
3582-3587 |
MD |
denotes |
would |
T21419 |
3595-3597 |
IN |
denotes |
by |
T21420 |
3598-3613 |
NN |
denotes |
oligomerization |
T21421 |
3614-3616 |
IN |
denotes |
of |
T21422 |
3617-3620 |
DT |
denotes |
the |
T21423 |
3625-3631 |
NN |
denotes |
domain |
T21424 |
3621-3624 |
NN |
denotes |
SAM |
T21425 |
3631-3632 |
. |
denotes |
. |
T21426 |
3632-3725 |
sentence |
denotes |
In contrast to TEL, ph does not contain an obvious sequence-specific DNA binding motif (16). |
T21427 |
3633-3635 |
IN |
denotes |
In |
T21428 |
3665-3672 |
VB |
denotes |
contain |
T21429 |
3636-3644 |
NN |
denotes |
contrast |
T21430 |
3645-3647 |
IN |
denotes |
to |
T21431 |
3648-3651 |
NN |
denotes |
TEL |
T21432 |
3651-3653 |
, |
denotes |
, |
T21433 |
3653-3655 |
NN |
denotes |
ph |
T21434 |
3656-3660 |
VBZ |
denotes |
does |
T21435 |
3661-3664 |
RB |
denotes |
not |
T21436 |
3673-3675 |
DT |
denotes |
an |
T21437 |
3714-3719 |
NN |
denotes |
motif |
T21438 |
3676-3683 |
JJ |
denotes |
obvious |
T21439 |
3684-3692 |
NN |
denotes |
sequence |
T21440 |
3693-3701 |
JJ |
denotes |
specific |
T21441 |
3692-3693 |
HYPH |
denotes |
- |
T21442 |
3702-3705 |
NN |
denotes |
DNA |
T21443 |
3706-3713 |
VBG |
denotes |
binding |
T21444 |
3720-3721 |
-LRB- |
denotes |
( |
T21445 |
3721-3723 |
CD |
denotes |
16 |
T21446 |
3723-3724 |
-RRB- |
denotes |
) |
T21447 |
3724-3725 |
. |
denotes |
. |
T21448 |
3725-3870 |
sentence |
denotes |
Therefore, its initial binding to the template may require protein-protein interactions with other sequence-specific transcriptional repressors. |
T21449 |
3726-3735 |
RB |
denotes |
Therefore |
T21450 |
3777-3784 |
VB |
denotes |
require |
T21451 |
3735-3737 |
, |
denotes |
, |
T21452 |
3737-3740 |
PRP$ |
denotes |
its |
T21453 |
3749-3756 |
NN |
denotes |
binding |
T21454 |
3741-3748 |
JJ |
denotes |
initial |
T21455 |
3757-3759 |
IN |
denotes |
to |
T21456 |
3760-3763 |
DT |
denotes |
the |
T21457 |
3764-3772 |
NN |
denotes |
template |
T21458 |
3773-3776 |
MD |
denotes |
may |
T21459 |
3785-3792 |
NN |
denotes |
protein |
T21460 |
3793-3800 |
NN |
denotes |
protein |
T21461 |
3792-3793 |
HYPH |
denotes |
- |
T21462 |
3801-3813 |
NNS |
denotes |
interactions |
T21463 |
3814-3818 |
IN |
denotes |
with |
T21464 |
3819-3824 |
JJ |
denotes |
other |
T21465 |
3859-3869 |
NNS |
denotes |
repressors |
T21466 |
3825-3833 |
NN |
denotes |
sequence |
T21467 |
3834-3842 |
JJ |
denotes |
specific |
T21468 |
3833-3834 |
HYPH |
denotes |
- |
T21469 |
3843-3858 |
JJ |
denotes |
transcriptional |
T21470 |
3869-3870 |
. |
denotes |
. |
T21471 |
3870-4069 |
sentence |
denotes |
The segmentation gene-encoding transcriptional repressors such as Hunchback have a role in recruiting SAM domain-containing PcG proteins, which can spread along the template via polymerization [42]. |
T21472 |
3871-3874 |
DT |
denotes |
The |
T21473 |
3918-3928 |
NNS |
denotes |
repressors |
T21474 |
3875-3887 |
NN |
denotes |
segmentation |
T21475 |
3888-3892 |
NN |
denotes |
gene |
T21476 |
3893-3901 |
VBG |
denotes |
encoding |
T21477 |
3892-3893 |
HYPH |
denotes |
- |
T21478 |
3902-3917 |
JJ |
denotes |
transcriptional |
T21479 |
3947-3951 |
VBP |
denotes |
have |
T21480 |
3929-3933 |
JJ |
denotes |
such |
T21481 |
3934-3936 |
IN |
denotes |
as |
T21482 |
3937-3946 |
NN |
denotes |
Hunchback |
T21483 |
3952-3953 |
DT |
denotes |
a |
T21484 |
3954-3958 |
NN |
denotes |
role |
T21485 |
3959-3961 |
IN |
denotes |
in |
T21486 |
3962-3972 |
VBG |
denotes |
recruiting |
T21487 |
3973-3976 |
NN |
denotes |
SAM |
T21488 |
3999-4007 |
NN |
denotes |
proteins |
T21489 |
3977-3983 |
NN |
denotes |
domain |
T21490 |
3984-3994 |
VBG |
denotes |
containing |
T21491 |
3983-3984 |
HYPH |
denotes |
- |
T21492 |
3995-3998 |
NN |
denotes |
PcG |
T21493 |
4007-4009 |
, |
denotes |
, |
T21494 |
4009-4014 |
WDT |
denotes |
which |
T21495 |
4019-4025 |
VB |
denotes |
spread |
T21496 |
4015-4018 |
MD |
denotes |
can |
T21497 |
4026-4031 |
IN |
denotes |
along |
T21498 |
4032-4035 |
DT |
denotes |
the |
T21499 |
4036-4044 |
NN |
denotes |
template |
T21500 |
4045-4048 |
IN |
denotes |
via |
T21501 |
4049-4063 |
NN |
denotes |
polymerization |
T21502 |
4064-4065 |
-LRB- |
denotes |
[ |
T21503 |
4065-4067 |
CD |
denotes |
42 |
T21504 |
4067-4068 |
-RRB- |
denotes |
] |
T21505 |
4068-4069 |
. |
denotes |
. |
T21506 |
4069-4221 |
sentence |
denotes |
Since mr-s does not contain obvious DNA binding motifs, we suppose that there is a sequence-specific transcription factor(s) which interacts with mr-s. |
T21507 |
4070-4075 |
IN |
denotes |
Since |
T21508 |
4090-4097 |
VB |
denotes |
contain |
T21509 |
4076-4078 |
NN |
denotes |
mr |
T21510 |
4079-4080 |
NN |
denotes |
s |
T21511 |
4078-4079 |
HYPH |
denotes |
- |
T21512 |
4081-4085 |
VBZ |
denotes |
does |
T21513 |
4086-4089 |
RB |
denotes |
not |
T21514 |
4129-4136 |
VBP |
denotes |
suppose |
T21515 |
4098-4105 |
JJ |
denotes |
obvious |
T21516 |
4118-4124 |
NNS |
denotes |
motifs |
T21517 |
4106-4109 |
NN |
denotes |
DNA |
T21518 |
4110-4117 |
VBG |
denotes |
binding |
T21519 |
4124-4126 |
, |
denotes |
, |
T21520 |
4126-4128 |
PRP |
denotes |
we |
T21521 |
4137-4141 |
IN |
denotes |
that |
T21522 |
4148-4150 |
VBZ |
denotes |
is |
T21523 |
4142-4147 |
EX |
denotes |
there |
T21524 |
4151-4152 |
DT |
denotes |
a |
T21525 |
4185-4191 |
NN |
denotes |
factor |
T21526 |
4153-4161 |
NN |
denotes |
sequence |
T21527 |
4162-4170 |
JJ |
denotes |
specific |
T21528 |
4161-4162 |
HYPH |
denotes |
- |
T21529 |
4171-4184 |
NN |
denotes |
transcription |
T21530 |
4191-4192 |
-LRB- |
denotes |
( |
T21531 |
4192-4193 |
AFX |
denotes |
s |
T21532 |
4193-4194 |
-RRB- |
denotes |
) |
T21533 |
4195-4200 |
WDT |
denotes |
which |
T21534 |
4201-4210 |
VBZ |
denotes |
interacts |
T21535 |
4211-4215 |
IN |
denotes |
with |
T21536 |
4216-4218 |
NN |
denotes |
mr |
T21537 |
4219-4220 |
NN |
denotes |
s |
T21538 |
4218-4219 |
HYPH |
denotes |
- |
T21539 |
4220-4221 |
. |
denotes |
. |
T21540 |
4221-4315 |
sentence |
denotes |
However, we did not find any transcription factors in the present yeast two-hybrid screening. |
T21541 |
4222-4229 |
RB |
denotes |
However |
T21542 |
4242-4246 |
VB |
denotes |
find |
T21543 |
4229-4231 |
, |
denotes |
, |
T21544 |
4231-4233 |
PRP |
denotes |
we |
T21545 |
4234-4237 |
VBD |
denotes |
did |
T21546 |
4238-4241 |
RB |
denotes |
not |
T21547 |
4247-4250 |
DT |
denotes |
any |
T21548 |
4265-4272 |
NNS |
denotes |
factors |
T21549 |
4251-4264 |
NN |
denotes |
transcription |
T21550 |
4273-4275 |
IN |
denotes |
in |
T21551 |
4276-4279 |
DT |
denotes |
the |
T21552 |
4305-4314 |
NN |
denotes |
screening |
T21553 |
4280-4287 |
JJ |
denotes |
present |
T21554 |
4288-4293 |
NN |
denotes |
yeast |
T21555 |
4294-4297 |
CD |
denotes |
two |
T21556 |
4298-4304 |
NN |
denotes |
hybrid |
T21557 |
4297-4298 |
HYPH |
denotes |
- |
T21558 |
4314-4315 |
. |
denotes |
. |
T21559 |
4315-4440 |
sentence |
denotes |
We also found that full-length mr-s fused to the GAL4 DNA binding domain (DBD-mrs) functions as a transcriptional repressor. |
T21560 |
4316-4318 |
PRP |
denotes |
We |
T21561 |
4324-4329 |
VBD |
denotes |
found |
T21562 |
4319-4323 |
RB |
denotes |
also |
T21563 |
4330-4334 |
IN |
denotes |
that |
T21564 |
4399-4408 |
VBZ |
denotes |
functions |
T21565 |
4335-4339 |
JJ |
denotes |
full |
T21566 |
4340-4346 |
NN |
denotes |
length |
T21567 |
4339-4340 |
HYPH |
denotes |
- |
T21568 |
4350-4351 |
NN |
denotes |
s |
T21569 |
4347-4349 |
NN |
denotes |
mr |
T21570 |
4349-4350 |
HYPH |
denotes |
- |
T21571 |
4352-4357 |
VBN |
denotes |
fused |
T21572 |
4358-4360 |
IN |
denotes |
to |
T21573 |
4361-4364 |
DT |
denotes |
the |
T21574 |
4382-4388 |
NN |
denotes |
domain |
T21575 |
4365-4369 |
NN |
denotes |
GAL4 |
T21576 |
4370-4373 |
NN |
denotes |
DNA |
T21577 |
4374-4381 |
VBG |
denotes |
binding |
T21578 |
4389-4390 |
-LRB- |
denotes |
( |
T21579 |
4394-4397 |
NN |
denotes |
mrs |
T21580 |
4390-4393 |
NN |
denotes |
DBD |
T21581 |
4393-4394 |
HYPH |
denotes |
- |
T21582 |
4397-4398 |
-RRB- |
denotes |
) |
T21583 |
4409-4411 |
IN |
denotes |
as |
T21584 |
4412-4413 |
DT |
denotes |
a |
T21585 |
4430-4439 |
NN |
denotes |
repressor |
T21586 |
4414-4429 |
JJ |
denotes |
transcriptional |
T21587 |
4439-4440 |
. |
denotes |
. |
T21588 |
4440-4561 |
sentence |
denotes |
This may support the idea that mr-s is involved in repressive complexes similar to other SAM domain-containing proteins. |
T21589 |
4441-4445 |
DT |
denotes |
This |
T21590 |
4450-4457 |
VB |
denotes |
support |
T21591 |
4446-4449 |
MD |
denotes |
may |
T21592 |
4458-4461 |
DT |
denotes |
the |
T21593 |
4462-4466 |
NN |
denotes |
idea |
T21594 |
4467-4471 |
IN |
denotes |
that |
T21595 |
4480-4488 |
VBN |
denotes |
involved |
T21596 |
4472-4474 |
NN |
denotes |
mr |
T21597 |
4475-4476 |
NN |
denotes |
s |
T21598 |
4474-4475 |
HYPH |
denotes |
- |
T21599 |
4477-4479 |
VBZ |
denotes |
is |
T21600 |
4489-4491 |
IN |
denotes |
in |
T21601 |
4492-4502 |
JJ |
denotes |
repressive |
T21602 |
4503-4512 |
NNS |
denotes |
complexes |
T21603 |
4513-4520 |
JJ |
denotes |
similar |
T21604 |
4521-4523 |
IN |
denotes |
to |
T21605 |
4524-4529 |
JJ |
denotes |
other |
T21606 |
4552-4560 |
NN |
denotes |
proteins |
T21607 |
4530-4533 |
NN |
denotes |
SAM |
T21608 |
4534-4540 |
NN |
denotes |
domain |
T21609 |
4541-4551 |
VBG |
denotes |
containing |
T21610 |
4540-4541 |
HYPH |
denotes |
- |
T21611 |
4560-4561 |
. |
denotes |
. |
T21612 |
4561-4709 |
sentence |
denotes |
Our results, however, showed that the self-association of mr-s through its SAM domain is not essential for the transcriptional repressive activity. |
T21613 |
4562-4565 |
PRP$ |
denotes |
Our |
T21614 |
4566-4573 |
NNS |
denotes |
results |
T21615 |
4584-4590 |
VBD |
denotes |
showed |
T21616 |
4573-4575 |
, |
denotes |
, |
T21617 |
4575-4582 |
RB |
denotes |
however |
T21618 |
4582-4584 |
, |
denotes |
, |
T21619 |
4591-4595 |
IN |
denotes |
that |
T21620 |
4648-4650 |
VBZ |
denotes |
is |
T21621 |
4596-4599 |
DT |
denotes |
the |
T21622 |
4605-4616 |
NN |
denotes |
association |
T21623 |
4600-4604 |
NN |
denotes |
self |
T21624 |
4604-4605 |
HYPH |
denotes |
- |
T21625 |
4617-4619 |
IN |
denotes |
of |
T21626 |
4620-4622 |
NN |
denotes |
mr |
T21627 |
4623-4624 |
NN |
denotes |
s |
T21628 |
4622-4623 |
HYPH |
denotes |
- |
T21629 |
4625-4632 |
IN |
denotes |
through |
T21630 |
4633-4636 |
PRP$ |
denotes |
its |
T21631 |
4641-4647 |
NN |
denotes |
domain |
T21632 |
4637-4640 |
NN |
denotes |
SAM |
T21633 |
4651-4654 |
RB |
denotes |
not |
T21634 |
4655-4664 |
JJ |
denotes |
essential |
T21635 |
4665-4668 |
IN |
denotes |
for |
T21636 |
4669-4672 |
DT |
denotes |
the |
T21637 |
4700-4708 |
NN |
denotes |
activity |
T21638 |
4673-4688 |
JJ |
denotes |
transcriptional |
T21639 |
4689-4699 |
JJ |
denotes |
repressive |
T21640 |
4708-4709 |
. |
denotes |
. |
T21641 |
4709-4839 |
sentence |
denotes |
Polymerization of the SAM domain has been previously reported to be essential for the repressive functions of ph and TEL [43,44]. |
T21642 |
4710-4724 |
NN |
denotes |
Polymerization |
T21643 |
4763-4771 |
VBN |
denotes |
reported |
T21644 |
4725-4727 |
IN |
denotes |
of |
T21645 |
4728-4731 |
DT |
denotes |
the |
T21646 |
4736-4742 |
NN |
denotes |
domain |
T21647 |
4732-4735 |
NN |
denotes |
SAM |
T21648 |
4743-4746 |
VBZ |
denotes |
has |
T21649 |
4747-4751 |
VBN |
denotes |
been |
T21650 |
4752-4762 |
RB |
denotes |
previously |
T21651 |
4772-4774 |
TO |
denotes |
to |
T21652 |
4775-4777 |
VB |
denotes |
be |
T21653 |
4778-4787 |
JJ |
denotes |
essential |
T21654 |
4788-4791 |
IN |
denotes |
for |
T21655 |
4792-4795 |
DT |
denotes |
the |
T21656 |
4807-4816 |
NNS |
denotes |
functions |
T21657 |
4796-4806 |
JJ |
denotes |
repressive |
T21658 |
4817-4819 |
IN |
denotes |
of |
T21659 |
4820-4822 |
NN |
denotes |
ph |
T21660 |
4823-4826 |
CC |
denotes |
and |
T21661 |
4827-4830 |
NN |
denotes |
TEL |
T21662 |
4831-4832 |
-LRB- |
denotes |
[ |
T21663 |
4835-4837 |
CD |
denotes |
44 |
T21664 |
4832-4834 |
CD |
denotes |
43 |
T21665 |
4834-4835 |
, |
denotes |
, |
T21666 |
4837-4838 |
-RRB- |
denotes |
] |
T21667 |
4838-4839 |
. |
denotes |
. |
T21668 |
4839-5130 |
sentence |
denotes |
On the other hand, human lethal(3) malignant brain tumor (H-L(3)MBT) protein, which also contains a SAM domain at the C-terminus, was reported as a transcriptional repressor and the repressor activity of H-L(3)MBT required mainly the presence of the MBT repeats but not the SAM domain [45]. |
T21669 |
4840-4842 |
IN |
denotes |
On |
T21670 |
4974-4982 |
VBN |
denotes |
reported |
T21671 |
4843-4846 |
DT |
denotes |
the |
T21672 |
4853-4857 |
NN |
denotes |
hand |
T21673 |
4847-4852 |
JJ |
denotes |
other |
T21674 |
4857-4859 |
, |
denotes |
, |
T21675 |
4859-4864 |
JJ |
denotes |
human |
T21676 |
4909-4916 |
NN |
denotes |
protein |
T21677 |
4865-4871 |
JJ |
denotes |
lethal |
T21678 |
4871-4872 |
-LRB- |
denotes |
( |
T21679 |
4872-4873 |
CD |
denotes |
3 |
T21680 |
4873-4874 |
-RRB- |
denotes |
) |
T21681 |
4875-4884 |
JJ |
denotes |
malignant |
T21682 |
4891-4896 |
NN |
denotes |
tumor |
T21683 |
4885-4890 |
NN |
denotes |
brain |
T21684 |
4897-4898 |
-LRB- |
denotes |
( |
T21685 |
4902-4903 |
CD |
denotes |
3 |
T21686 |
4898-4899 |
NN |
denotes |
H |
T21687 |
4899-4900 |
SYM |
denotes |
- |
T21688 |
4900-4901 |
NN |
denotes |
L |
T21689 |
4901-4902 |
-LRB- |
denotes |
( |
T21690 |
4903-4904 |
-RRB- |
denotes |
) |
T21691 |
4904-4907 |
NN |
denotes |
MBT |
T21692 |
4907-4908 |
-RRB- |
denotes |
) |
T21693 |
4916-4918 |
, |
denotes |
, |
T21694 |
4918-4923 |
WDT |
denotes |
which |
T21695 |
4929-4937 |
VBZ |
denotes |
contains |
T21696 |
4924-4928 |
RB |
denotes |
also |
T21697 |
4938-4939 |
DT |
denotes |
a |
T21698 |
4944-4950 |
NN |
denotes |
domain |
T21699 |
4940-4943 |
NN |
denotes |
SAM |
T21700 |
4951-4953 |
IN |
denotes |
at |
T21701 |
4954-4957 |
DT |
denotes |
the |
T21702 |
4960-4968 |
NN |
denotes |
terminus |
T21703 |
4958-4959 |
NN |
denotes |
C |
T21704 |
4959-4960 |
HYPH |
denotes |
- |
T21705 |
4968-4970 |
, |
denotes |
, |
T21706 |
4970-4973 |
VBD |
denotes |
was |
T21707 |
4983-4985 |
IN |
denotes |
as |
T21708 |
4986-4987 |
DT |
denotes |
a |
T21709 |
5004-5013 |
NN |
denotes |
repressor |
T21710 |
4988-5003 |
JJ |
denotes |
transcriptional |
T21711 |
5014-5017 |
CC |
denotes |
and |
T21712 |
5018-5021 |
DT |
denotes |
the |
T21713 |
5032-5040 |
NN |
denotes |
activity |
T21714 |
5022-5031 |
NN |
denotes |
repressor |
T21715 |
5054-5062 |
VBD |
denotes |
required |
T21716 |
5041-5043 |
IN |
denotes |
of |
T21717 |
5044-5045 |
NN |
denotes |
H |
T21718 |
5050-5053 |
NN |
denotes |
MBT |
T21719 |
5045-5046 |
SYM |
denotes |
- |
T21720 |
5046-5047 |
NN |
denotes |
L |
T21721 |
5047-5048 |
-LRB- |
denotes |
( |
T21722 |
5048-5049 |
CD |
denotes |
3 |
T21723 |
5049-5050 |
-RRB- |
denotes |
) |
T21724 |
5063-5069 |
RB |
denotes |
mainly |
T21725 |
5070-5073 |
DT |
denotes |
the |
T21726 |
5074-5082 |
NN |
denotes |
presence |
T21727 |
5083-5085 |
IN |
denotes |
of |
T21728 |
5086-5089 |
DT |
denotes |
the |
T21729 |
5094-5101 |
NNS |
denotes |
repeats |
T21730 |
5090-5093 |
NN |
denotes |
MBT |
T21731 |
5102-5105 |
CC |
denotes |
but |
T21732 |
5106-5109 |
RB |
denotes |
not |
T21733 |
5110-5113 |
DT |
denotes |
the |
T21734 |
5118-5124 |
NN |
denotes |
domain |
T21735 |
5114-5117 |
NN |
denotes |
SAM |
T21736 |
5125-5126 |
-LRB- |
denotes |
[ |
T21737 |
5126-5128 |
CD |
denotes |
45 |
T21738 |
5128-5129 |
-RRB- |
denotes |
] |
T21739 |
5129-5130 |
. |
denotes |
. |
T21740 |
5130-5288 |
sentence |
denotes |
To determine the transcriptional repressor region of the mr-s protein, we performed a luciferase assay using site-directed mutants (DBD-W404A and DBD-G453A). |
T21741 |
5131-5133 |
TO |
denotes |
To |
T21742 |
5134-5143 |
VB |
denotes |
determine |
T21743 |
5205-5214 |
VBD |
denotes |
performed |
T21744 |
5144-5147 |
DT |
denotes |
the |
T21745 |
5174-5180 |
NN |
denotes |
region |
T21746 |
5148-5163 |
JJ |
denotes |
transcriptional |
T21747 |
5164-5173 |
NN |
denotes |
repressor |
T21748 |
5181-5183 |
IN |
denotes |
of |
T21749 |
5184-5187 |
DT |
denotes |
the |
T21750 |
5193-5200 |
NN |
denotes |
protein |
T21751 |
5188-5190 |
NN |
denotes |
mr |
T21752 |
5191-5192 |
NN |
denotes |
s |
T21753 |
5190-5191 |
HYPH |
denotes |
- |
T21754 |
5200-5202 |
, |
denotes |
, |
T21755 |
5202-5204 |
PRP |
denotes |
we |
T21756 |
5215-5216 |
DT |
denotes |
a |
T21757 |
5228-5233 |
NN |
denotes |
assay |
T21758 |
5217-5227 |
NN |
denotes |
luciferase |
T21759 |
5234-5239 |
VBG |
denotes |
using |
T21760 |
5240-5244 |
NN |
denotes |
site |
T21761 |
5245-5253 |
VBN |
denotes |
directed |
T21762 |
5244-5245 |
HYPH |
denotes |
- |
T21763 |
5254-5261 |
NNS |
denotes |
mutants |
T21764 |
5262-5263 |
-LRB- |
denotes |
( |
T21765 |
5267-5272 |
NN |
denotes |
W404A |
T21766 |
5263-5266 |
NN |
denotes |
DBD |
T21767 |
5266-5267 |
HYPH |
denotes |
- |
T21768 |
5273-5276 |
CC |
denotes |
and |
T21769 |
5277-5280 |
NN |
denotes |
DBD |
T21770 |
5281-5286 |
NN |
denotes |
G453A |
T21771 |
5280-5281 |
HYPH |
denotes |
- |
T21772 |
5286-5287 |
-RRB- |
denotes |
) |
T21773 |
5287-5288 |
. |
denotes |
. |
T21774 |
5288-5440 |
sentence |
denotes |
The result showed that the reduced binding ability of self-association partially compromises the transcriptional repressive activity of mr-s (Fig. 7D). |
T21775 |
5289-5292 |
DT |
denotes |
The |
T21776 |
5293-5299 |
NN |
denotes |
result |
T21777 |
5300-5306 |
VBD |
denotes |
showed |
T21778 |
5307-5311 |
IN |
denotes |
that |
T21779 |
5370-5381 |
VBZ |
denotes |
compromises |
T21780 |
5312-5315 |
DT |
denotes |
the |
T21781 |
5332-5339 |
NN |
denotes |
ability |
T21782 |
5316-5323 |
VBN |
denotes |
reduced |
T21783 |
5324-5331 |
NN |
denotes |
binding |
T21784 |
5340-5342 |
IN |
denotes |
of |
T21785 |
5343-5347 |
NN |
denotes |
self |
T21786 |
5348-5359 |
NN |
denotes |
association |
T21787 |
5347-5348 |
HYPH |
denotes |
- |
T21788 |
5360-5369 |
RB |
denotes |
partially |
T21789 |
5382-5385 |
DT |
denotes |
the |
T21790 |
5413-5421 |
NN |
denotes |
activity |
T21791 |
5386-5401 |
JJ |
denotes |
transcriptional |
T21792 |
5402-5412 |
JJ |
denotes |
repressive |
T21793 |
5422-5424 |
IN |
denotes |
of |
T21794 |
5425-5427 |
NN |
denotes |
mr |
T21795 |
5428-5429 |
NN |
denotes |
s |
T21796 |
5427-5428 |
HYPH |
denotes |
- |
T21797 |
5430-5431 |
-LRB- |
denotes |
( |
T21798 |
5436-5438 |
NN |
denotes |
7D |
T21799 |
5431-5435 |
NN |
denotes |
Fig. |
T21800 |
5438-5439 |
-RRB- |
denotes |
) |
T21801 |
5439-5440 |
. |
denotes |
. |
T21802 |
5440-5599 |
sentence |
denotes |
However, the repressive effect was more significant when DBD-tail, which does not contain SAM domain, was co-introduced with the 5xGAL4-pGL3 reporter plasmid. |
T21803 |
5441-5448 |
RB |
denotes |
However |
T21804 |
5472-5475 |
VBD |
denotes |
was |
T21805 |
5448-5450 |
, |
denotes |
, |
T21806 |
5450-5453 |
DT |
denotes |
the |
T21807 |
5465-5471 |
NN |
denotes |
effect |
T21808 |
5454-5464 |
JJ |
denotes |
repressive |
T21809 |
5476-5480 |
RBR |
denotes |
more |
T21810 |
5481-5492 |
JJ |
denotes |
significant |
T21811 |
5493-5497 |
WRB |
denotes |
when |
T21812 |
5547-5560 |
VBN |
denotes |
co-introduced |
T21813 |
5498-5501 |
NN |
denotes |
DBD |
T21814 |
5502-5506 |
NN |
denotes |
tail |
T21815 |
5501-5502 |
HYPH |
denotes |
- |
T21816 |
5506-5508 |
, |
denotes |
, |
T21817 |
5508-5513 |
WDT |
denotes |
which |
T21818 |
5523-5530 |
VB |
denotes |
contain |
T21819 |
5514-5518 |
VBZ |
denotes |
does |
T21820 |
5519-5522 |
RB |
denotes |
not |
T21821 |
5531-5534 |
NN |
denotes |
SAM |
T21822 |
5535-5541 |
NN |
denotes |
domain |
T21823 |
5541-5543 |
, |
denotes |
, |
T21824 |
5543-5546 |
VBD |
denotes |
was |
T21825 |
5561-5565 |
IN |
denotes |
with |
T21826 |
5566-5569 |
DT |
denotes |
the |
T21827 |
5591-5598 |
NN |
denotes |
plasmid |
T21828 |
5570-5576 |
NN |
denotes |
5xGAL4 |
T21829 |
5577-5581 |
NN |
denotes |
pGL3 |
T21830 |
5576-5577 |
HYPH |
denotes |
- |
T21831 |
5582-5590 |
NN |
denotes |
reporter |
T21832 |
5598-5599 |
. |
denotes |
. |
T21833 |
5599-5734 |
sentence |
denotes |
Therefore, we conclude that a region from amino acids 463 to 542 is mainly responsible for the repressor activity in the case of mr-s. |
T21834 |
5600-5609 |
RB |
denotes |
Therefore |
T21835 |
5614-5622 |
VBP |
denotes |
conclude |
T21836 |
5609-5611 |
, |
denotes |
, |
T21837 |
5611-5613 |
PRP |
denotes |
we |
T21838 |
5623-5627 |
IN |
denotes |
that |
T21839 |
5665-5667 |
VBZ |
denotes |
is |
T21840 |
5628-5629 |
DT |
denotes |
a |
T21841 |
5630-5636 |
NN |
denotes |
region |
T21842 |
5637-5641 |
IN |
denotes |
from |
T21843 |
5642-5647 |
NN |
denotes |
amino |
T21844 |
5654-5657 |
CD |
denotes |
463 |
T21845 |
5648-5653 |
NNS |
denotes |
acids |
T21846 |
5658-5660 |
IN |
denotes |
to |
T21847 |
5661-5664 |
CD |
denotes |
542 |
T21848 |
5668-5674 |
RB |
denotes |
mainly |
T21849 |
5675-5686 |
JJ |
denotes |
responsible |
T21850 |
5687-5690 |
IN |
denotes |
for |
T21851 |
5691-5694 |
DT |
denotes |
the |
T21852 |
5705-5713 |
NN |
denotes |
activity |
T21853 |
5695-5704 |
NN |
denotes |
repressor |
T21854 |
5714-5716 |
IN |
denotes |
in |
T21855 |
5717-5720 |
DT |
denotes |
the |
T21856 |
5721-5725 |
NN |
denotes |
case |
T21857 |
5726-5728 |
IN |
denotes |
of |
T21858 |
5729-5731 |
NN |
denotes |
mr |
T21859 |
5732-5733 |
NN |
denotes |
s |
T21860 |
5731-5732 |
HYPH |
denotes |
- |
T21861 |
5733-5734 |
. |
denotes |
. |
T21862 |
5734-5883 |
sentence |
denotes |
Evolutionary conservation of the C-terminal 80 aa region of mr-s from zebrafish through human may underlie the functional importance of this region. |
T21863 |
5735-5747 |
JJ |
denotes |
Evolutionary |
T21864 |
5748-5760 |
NN |
denotes |
conservation |
T21865 |
5833-5841 |
VB |
denotes |
underlie |
T21866 |
5761-5763 |
IN |
denotes |
of |
T21867 |
5764-5767 |
DT |
denotes |
the |
T21868 |
5785-5791 |
NN |
denotes |
region |
T21869 |
5768-5769 |
NN |
denotes |
C |
T21870 |
5770-5778 |
JJ |
denotes |
terminal |
T21871 |
5769-5770 |
HYPH |
denotes |
- |
T21872 |
5779-5781 |
CD |
denotes |
80 |
T21873 |
5782-5784 |
NN |
denotes |
aa |
T21874 |
5792-5794 |
IN |
denotes |
of |
T21875 |
5795-5797 |
NN |
denotes |
mr |
T21876 |
5798-5799 |
NN |
denotes |
s |
T21877 |
5797-5798 |
HYPH |
denotes |
- |
T21878 |
5800-5804 |
IN |
denotes |
from |
T21879 |
5805-5814 |
NN |
denotes |
zebrafish |
T21880 |
5815-5822 |
IN |
denotes |
through |
T21881 |
5823-5828 |
JJ |
denotes |
human |
T21882 |
5829-5832 |
MD |
denotes |
may |
T21883 |
5842-5845 |
DT |
denotes |
the |
T21884 |
5857-5867 |
NN |
denotes |
importance |
T21885 |
5846-5856 |
JJ |
denotes |
functional |
T21886 |
5868-5870 |
IN |
denotes |
of |
T21887 |
5871-5875 |
DT |
denotes |
this |
T21888 |
5876-5882 |
NN |
denotes |
region |
T21889 |
5882-5883 |
. |
denotes |
. |
T21890 |
5883-5961 |
sentence |
denotes |
Two distinct multiprotein PcG complexes, PRC1 and PRC2, have been identified. |
T21891 |
5884-5887 |
CD |
denotes |
Two |
T21892 |
5914-5923 |
NNS |
denotes |
complexes |
T21893 |
5888-5896 |
JJ |
denotes |
distinct |
T21894 |
5897-5909 |
NN |
denotes |
multiprotein |
T21895 |
5910-5913 |
NN |
denotes |
PcG |
T21896 |
5950-5960 |
VBN |
denotes |
identified |
T21897 |
5923-5925 |
, |
denotes |
, |
T21898 |
5925-5929 |
NN |
denotes |
PRC1 |
T21899 |
5930-5933 |
CC |
denotes |
and |
T21900 |
5934-5938 |
NN |
denotes |
PRC2 |
T21901 |
5938-5940 |
, |
denotes |
, |
T21902 |
5940-5944 |
VBP |
denotes |
have |
T21903 |
5945-5949 |
VBN |
denotes |
been |
T21904 |
5960-5961 |
. |
denotes |
. |
T21905 |
5961-6160 |
sentence |
denotes |
PRC2 is involved in the initiation of silencing and contains histone deacetylases (HDACs) and histone methyltransferases, which can methylate histone H3 lysine 9 and 27, marks of silenced chromatin. |
T21906 |
5962-5966 |
NN |
denotes |
PRC2 |
T21907 |
5970-5978 |
VBN |
denotes |
involved |
T21908 |
5967-5969 |
VBZ |
denotes |
is |
T21909 |
5979-5981 |
IN |
denotes |
in |
T21910 |
5982-5985 |
DT |
denotes |
the |
T21911 |
5986-5996 |
NN |
denotes |
initiation |
T21912 |
5997-5999 |
IN |
denotes |
of |
T21913 |
6000-6009 |
NN |
denotes |
silencing |
T21914 |
6010-6013 |
CC |
denotes |
and |
T21915 |
6014-6022 |
VBZ |
denotes |
contains |
T21916 |
6023-6030 |
NN |
denotes |
histone |
T21917 |
6031-6043 |
NNS |
denotes |
deacetylases |
T21918 |
6044-6045 |
-LRB- |
denotes |
( |
T21919 |
6045-6050 |
NNS |
denotes |
HDACs |
T21920 |
6050-6051 |
-RRB- |
denotes |
) |
T21921 |
6052-6055 |
CC |
denotes |
and |
T21922 |
6056-6063 |
NN |
denotes |
histone |
T21923 |
6064-6082 |
NNS |
denotes |
methyltransferases |
T21924 |
6082-6084 |
, |
denotes |
, |
T21925 |
6084-6089 |
WDT |
denotes |
which |
T21926 |
6094-6103 |
VB |
denotes |
methylate |
T21927 |
6090-6093 |
MD |
denotes |
can |
T21928 |
6104-6111 |
NN |
denotes |
histone |
T21929 |
6122-6123 |
CD |
denotes |
9 |
T21930 |
6112-6114 |
NN |
denotes |
H3 |
T21931 |
6115-6121 |
NN |
denotes |
lysine |
T21932 |
6124-6127 |
CC |
denotes |
and |
T21933 |
6128-6130 |
CD |
denotes |
27 |
T21934 |
6130-6132 |
, |
denotes |
, |
T21935 |
6132-6137 |
NNS |
denotes |
marks |
T21936 |
6138-6140 |
IN |
denotes |
of |
T21937 |
6141-6149 |
VBN |
denotes |
silenced |
T21938 |
6150-6159 |
NN |
denotes |
chromatin |
T21939 |
6159-6160 |
. |
denotes |
. |
T21940 |
6160-6379 |
sentence |
denotes |
PRC1, including ph, recognizes the histone H3 lysine 27 mark set by PRC2 and maintains a stable state of gene repression in which PRC1 blocks chromatin remodeling by the trithorax group-related SWI-SNF complex [46,47]. |
T21941 |
6161-6165 |
NN |
denotes |
PRC1 |
T21942 |
6181-6191 |
VBZ |
denotes |
recognizes |
T21943 |
6165-6167 |
, |
denotes |
, |
T21944 |
6167-6176 |
VBG |
denotes |
including |
T21945 |
6177-6179 |
NN |
denotes |
ph |
T21946 |
6179-6181 |
, |
denotes |
, |
T21947 |
6192-6195 |
DT |
denotes |
the |
T21948 |
6217-6221 |
NN |
denotes |
mark |
T21949 |
6196-6203 |
NN |
denotes |
histone |
T21950 |
6204-6206 |
NN |
denotes |
H3 |
T21951 |
6207-6213 |
NN |
denotes |
lysine |
T21952 |
6214-6216 |
CD |
denotes |
27 |
T21953 |
6222-6225 |
VBN |
denotes |
set |
T21954 |
6226-6228 |
IN |
denotes |
by |
T21955 |
6229-6233 |
NN |
denotes |
PRC2 |
T21956 |
6234-6237 |
CC |
denotes |
and |
T21957 |
6238-6247 |
VBZ |
denotes |
maintains |
T21958 |
6248-6249 |
DT |
denotes |
a |
T21959 |
6257-6262 |
NN |
denotes |
state |
T21960 |
6250-6256 |
JJ |
denotes |
stable |
T21961 |
6263-6265 |
IN |
denotes |
of |
T21962 |
6266-6270 |
NN |
denotes |
gene |
T21963 |
6271-6281 |
NN |
denotes |
repression |
T21964 |
6282-6284 |
IN |
denotes |
in |
T21965 |
6296-6302 |
VBZ |
denotes |
blocks |
T21966 |
6285-6290 |
WDT |
denotes |
which |
T21967 |
6291-6295 |
NN |
denotes |
PRC1 |
T21968 |
6303-6312 |
NN |
denotes |
chromatin |
T21969 |
6313-6323 |
NN |
denotes |
remodeling |
T21970 |
6324-6326 |
IN |
denotes |
by |
T21971 |
6327-6330 |
DT |
denotes |
the |
T21972 |
6363-6370 |
NN |
denotes |
complex |
T21973 |
6331-6340 |
NN |
denotes |
trithorax |
T21974 |
6341-6346 |
NN |
denotes |
group |
T21975 |
6347-6354 |
VBN |
denotes |
related |
T21976 |
6346-6347 |
HYPH |
denotes |
- |
T21977 |
6355-6358 |
NN |
denotes |
SWI |
T21978 |
6359-6362 |
NN |
denotes |
SNF |
T21979 |
6358-6359 |
HYPH |
denotes |
- |
T21980 |
6371-6372 |
-LRB- |
denotes |
[ |
T21981 |
6375-6377 |
CD |
denotes |
47 |
T21982 |
6372-6374 |
CD |
denotes |
46 |
T21983 |
6374-6375 |
, |
denotes |
, |
T21984 |
6377-6378 |
-RRB- |
denotes |
] |
T21985 |
6378-6379 |
. |
denotes |
. |
T21986 |
6379-6532 |
sentence |
denotes |
Therefore, the mechanism of repression by PRC2 is thought to be HDAC-dependent while the mechanism of repression by PRC1 appears to be HDAC-independent. |
T21987 |
6380-6389 |
RB |
denotes |
Therefore |
T21988 |
6430-6437 |
VBN |
denotes |
thought |
T21989 |
6389-6391 |
, |
denotes |
, |
T21990 |
6391-6394 |
DT |
denotes |
the |
T21991 |
6395-6404 |
NN |
denotes |
mechanism |
T21992 |
6405-6407 |
IN |
denotes |
of |
T21993 |
6408-6418 |
NN |
denotes |
repression |
T21994 |
6419-6421 |
IN |
denotes |
by |
T21995 |
6422-6426 |
NN |
denotes |
PRC2 |
T21996 |
6427-6429 |
VBZ |
denotes |
is |
T21997 |
6438-6440 |
TO |
denotes |
to |
T21998 |
6441-6443 |
VB |
denotes |
be |
T21999 |
6444-6448 |
NN |
denotes |
HDAC |
T22000 |
6449-6458 |
JJ |
denotes |
dependent |
T22001 |
6448-6449 |
HYPH |
denotes |
- |
T22002 |
6459-6464 |
IN |
denotes |
while |
T22003 |
6501-6508 |
VBZ |
denotes |
appears |
T22004 |
6465-6468 |
DT |
denotes |
the |
T22005 |
6469-6478 |
NN |
denotes |
mechanism |
T22006 |
6479-6481 |
IN |
denotes |
of |
T22007 |
6482-6492 |
NN |
denotes |
repression |
T22008 |
6493-6495 |
IN |
denotes |
by |
T22009 |
6496-6500 |
NN |
denotes |
PRC1 |
T22010 |
6509-6511 |
TO |
denotes |
to |
T22011 |
6512-6514 |
VB |
denotes |
be |
T22012 |
6515-6519 |
NN |
denotes |
HDAC |
T22013 |
6520-6531 |
JJ |
denotes |
independent |
T22014 |
6519-6520 |
HYPH |
denotes |
- |
T22015 |
6531-6532 |
. |
denotes |
. |
T22016 |
6532-6728 |
sentence |
denotes |
Our luciferase assay also showed that transcriptional repression of DBD-mrs was not affected by the addition of various concentrations of trichostatin A, a potent HDAC inhibitor (data not shown). |
T22017 |
6533-6536 |
PRP$ |
denotes |
Our |
T22018 |
6548-6553 |
NN |
denotes |
assay |
T22019 |
6537-6547 |
NN |
denotes |
luciferase |
T22020 |
6559-6565 |
VBD |
denotes |
showed |
T22021 |
6554-6558 |
RB |
denotes |
also |
T22022 |
6566-6570 |
IN |
denotes |
that |
T22023 |
6617-6625 |
VBN |
denotes |
affected |
T22024 |
6571-6586 |
JJ |
denotes |
transcriptional |
T22025 |
6587-6597 |
NN |
denotes |
repression |
T22026 |
6598-6600 |
IN |
denotes |
of |
T22027 |
6601-6604 |
NN |
denotes |
DBD |
T22028 |
6605-6608 |
NN |
denotes |
mrs |
T22029 |
6604-6605 |
HYPH |
denotes |
- |
T22030 |
6609-6612 |
VBD |
denotes |
was |
T22031 |
6613-6616 |
RB |
denotes |
not |
T22032 |
6626-6628 |
IN |
denotes |
by |
T22033 |
6629-6632 |
DT |
denotes |
the |
T22034 |
6633-6641 |
NN |
denotes |
addition |
T22035 |
6642-6644 |
IN |
denotes |
of |
T22036 |
6645-6652 |
JJ |
denotes |
various |
T22037 |
6653-6667 |
NNS |
denotes |
concentrations |
T22038 |
6668-6670 |
IN |
denotes |
of |
T22039 |
6671-6683 |
NN |
denotes |
trichostatin |
T22040 |
6684-6685 |
NN |
denotes |
A |
T22041 |
6685-6687 |
, |
denotes |
, |
T22042 |
6687-6688 |
DT |
denotes |
a |
T22043 |
6701-6710 |
NN |
denotes |
inhibitor |
T22044 |
6689-6695 |
JJ |
denotes |
potent |
T22045 |
6696-6700 |
NN |
denotes |
HDAC |
T22046 |
6711-6712 |
-LRB- |
denotes |
( |
T22047 |
6721-6726 |
VBN |
denotes |
shown |
T22048 |
6712-6716 |
NNS |
denotes |
data |
T22049 |
6717-6720 |
RB |
denotes |
not |
T22050 |
6726-6727 |
-RRB- |
denotes |
) |
T22051 |
6727-6728 |
. |
denotes |
. |
T22052 |
6728-6859 |
sentence |
denotes |
Therefore, we speculate that the mechanism of repression of mr-s may be HDAC-independent and more similar to that of PRC1 complex. |
T22053 |
6729-6738 |
RB |
denotes |
Therefore |
T22054 |
6743-6752 |
VBP |
denotes |
speculate |
T22055 |
6738-6740 |
, |
denotes |
, |
T22056 |
6740-6742 |
PRP |
denotes |
we |
T22057 |
6753-6757 |
IN |
denotes |
that |
T22058 |
6798-6800 |
VB |
denotes |
be |
T22059 |
6758-6761 |
DT |
denotes |
the |
T22060 |
6762-6771 |
NN |
denotes |
mechanism |
T22061 |
6772-6774 |
IN |
denotes |
of |
T22062 |
6775-6785 |
NN |
denotes |
repression |
T22063 |
6786-6788 |
IN |
denotes |
of |
T22064 |
6789-6791 |
NN |
denotes |
mr |
T22065 |
6792-6793 |
NN |
denotes |
s |
T22066 |
6791-6792 |
HYPH |
denotes |
- |
T22067 |
6794-6797 |
MD |
denotes |
may |
T22068 |
6801-6805 |
NN |
denotes |
HDAC |
T22069 |
6806-6817 |
JJ |
denotes |
independent |
T22070 |
6805-6806 |
HYPH |
denotes |
- |
T22071 |
6818-6821 |
CC |
denotes |
and |
T22072 |
6822-6826 |
RBR |
denotes |
more |
T22073 |
6827-6834 |
JJ |
denotes |
similar |
T22074 |
6835-6837 |
IN |
denotes |
to |
T22075 |
6838-6842 |
DT |
denotes |
that |
T22076 |
6843-6845 |
IN |
denotes |
of |
T22077 |
6846-6850 |
NN |
denotes |
PRC1 |
T22078 |
6851-6858 |
NN |
denotes |
complex |
T22079 |
6858-6859 |
. |
denotes |
. |
T22080 |
6859-7110 |
sentence |
denotes |
In the present study, the biochemical experiments demonstrate that the mr-s protein functions as a transcriptional repressor and possibly down-regulates the spatial and temporal expression of the target genes during retinal photoreceptor development. |
T22081 |
6860-6862 |
IN |
denotes |
In |
T22082 |
6910-6921 |
VBP |
denotes |
demonstrate |
T22083 |
6863-6866 |
DT |
denotes |
the |
T22084 |
6875-6880 |
NN |
denotes |
study |
T22085 |
6867-6874 |
JJ |
denotes |
present |
T22086 |
6880-6882 |
, |
denotes |
, |
T22087 |
6882-6885 |
DT |
denotes |
the |
T22088 |
6898-6909 |
NNS |
denotes |
experiments |
T22089 |
6886-6897 |
JJ |
denotes |
biochemical |
T22090 |
6922-6926 |
IN |
denotes |
that |
T22091 |
6944-6953 |
VBZ |
denotes |
functions |
T22092 |
6927-6930 |
DT |
denotes |
the |
T22093 |
6936-6943 |
NN |
denotes |
protein |
T22094 |
6931-6933 |
NN |
denotes |
mr |
T22095 |
6934-6935 |
NN |
denotes |
s |
T22096 |
6933-6934 |
HYPH |
denotes |
- |
T22097 |
6954-6956 |
IN |
denotes |
as |
T22098 |
6957-6958 |
DT |
denotes |
a |
T22099 |
6975-6984 |
NN |
denotes |
repressor |
T22100 |
6959-6974 |
JJ |
denotes |
transcriptional |
T22101 |
6985-6988 |
CC |
denotes |
and |
T22102 |
6989-6997 |
RB |
denotes |
possibly |
T22103 |
7003-7012 |
VBZ |
denotes |
regulates |
T22104 |
6998-7002 |
RB |
denotes |
down |
T22105 |
7002-7003 |
HYPH |
denotes |
- |
T22106 |
7013-7016 |
DT |
denotes |
the |
T22107 |
7038-7048 |
NN |
denotes |
expression |
T22108 |
7017-7024 |
JJ |
denotes |
spatial |
T22109 |
7025-7028 |
CC |
denotes |
and |
T22110 |
7029-7037 |
JJ |
denotes |
temporal |
T22111 |
7049-7051 |
IN |
denotes |
of |
T22112 |
7052-7055 |
DT |
denotes |
the |
T22113 |
7063-7068 |
NNS |
denotes |
genes |
T22114 |
7056-7062 |
NN |
denotes |
target |
T22115 |
7069-7075 |
IN |
denotes |
during |
T22116 |
7076-7083 |
JJ |
denotes |
retinal |
T22117 |
7098-7109 |
NN |
denotes |
development |
T22118 |
7084-7097 |
NN |
denotes |
photoreceptor |
T22119 |
7109-7110 |
. |
denotes |
. |
T22120 |
7110-7235 |
sentence |
denotes |
Our data also revealed that the repressive activity of mr-s is mainly due to the C-terminal region (amino acids 463 to 542). |
T22121 |
7111-7114 |
PRP$ |
denotes |
Our |
T22122 |
7115-7119 |
NNS |
denotes |
data |
T22123 |
7125-7133 |
VBD |
denotes |
revealed |
T22124 |
7120-7124 |
RB |
denotes |
also |
T22125 |
7134-7138 |
IN |
denotes |
that |
T22126 |
7171-7173 |
VBZ |
denotes |
is |
T22127 |
7139-7142 |
DT |
denotes |
the |
T22128 |
7154-7162 |
NN |
denotes |
activity |
T22129 |
7143-7153 |
JJ |
denotes |
repressive |
T22130 |
7163-7165 |
IN |
denotes |
of |
T22131 |
7166-7168 |
NN |
denotes |
mr |
T22132 |
7169-7170 |
NN |
denotes |
s |
T22133 |
7168-7169 |
HYPH |
denotes |
- |
T22134 |
7174-7180 |
RB |
denotes |
mainly |
T22135 |
7181-7184 |
IN |
denotes |
due |
T22136 |
7185-7187 |
IN |
denotes |
to |
T22137 |
7188-7191 |
DT |
denotes |
the |
T22138 |
7203-7209 |
NN |
denotes |
region |
T22139 |
7192-7193 |
NN |
denotes |
C |
T22140 |
7194-7202 |
JJ |
denotes |
terminal |
T22141 |
7193-7194 |
HYPH |
denotes |
- |
T22142 |
7210-7211 |
-LRB- |
denotes |
( |
T22143 |
7223-7226 |
CD |
denotes |
463 |
T22144 |
7211-7216 |
NN |
denotes |
amino |
T22145 |
7217-7222 |
NNS |
denotes |
acids |
T22146 |
7227-7229 |
IN |
denotes |
to |
T22147 |
7230-7233 |
CD |
denotes |
542 |
T22148 |
7233-7234 |
-RRB- |
denotes |
) |
T22149 |
7234-7235 |
. |
denotes |
. |
T22150 |
7235-7293 |
sentence |
denotes |
However, downstream targets of mr-s still remain unclear. |
T22151 |
7236-7243 |
RB |
denotes |
However |
T22152 |
7278-7284 |
VBP |
denotes |
remain |
T22153 |
7243-7245 |
, |
denotes |
, |
T22154 |
7245-7255 |
JJ |
denotes |
downstream |
T22155 |
7256-7263 |
NNS |
denotes |
targets |
T22156 |
7264-7266 |
IN |
denotes |
of |
T22157 |
7267-7269 |
NN |
denotes |
mr |
T22158 |
7270-7271 |
NN |
denotes |
s |
T22159 |
7269-7270 |
HYPH |
denotes |
- |
T22160 |
7272-7277 |
RB |
denotes |
still |
T22161 |
7285-7292 |
JJ |
denotes |
unclear |
T22162 |
7292-7293 |
. |
denotes |
. |
T22163 |
7293-7431 |
sentence |
denotes |
In situ hybridization showed that the peak of mr-s expression is around P6, when retinal photoreceptors undergo terminal differentiation. |
T22164 |
7294-7296 |
FW |
denotes |
In |
T22165 |
7297-7301 |
FW |
denotes |
situ |
T22166 |
7302-7315 |
NN |
denotes |
hybridization |
T22167 |
7316-7322 |
VBD |
denotes |
showed |
T22168 |
7323-7327 |
IN |
denotes |
that |
T22169 |
7356-7358 |
VBZ |
denotes |
is |
T22170 |
7328-7331 |
DT |
denotes |
the |
T22171 |
7332-7336 |
NN |
denotes |
peak |
T22172 |
7337-7339 |
IN |
denotes |
of |
T22173 |
7340-7342 |
NN |
denotes |
mr |
T22174 |
7343-7344 |
NN |
denotes |
s |
T22175 |
7342-7343 |
HYPH |
denotes |
- |
T22176 |
7345-7355 |
NN |
denotes |
expression |
T22177 |
7359-7365 |
RB |
denotes |
around |
T22178 |
7366-7368 |
NN |
denotes |
P6 |
T22179 |
7368-7370 |
, |
denotes |
, |
T22180 |
7370-7374 |
WRB |
denotes |
when |
T22181 |
7398-7405 |
VBP |
denotes |
undergo |
T22182 |
7375-7382 |
JJ |
denotes |
retinal |
T22183 |
7383-7397 |
NNS |
denotes |
photoreceptors |
T22184 |
7406-7414 |
JJ |
denotes |
terminal |
T22185 |
7415-7430 |
NN |
denotes |
differentiation |
T22186 |
7430-7431 |
. |
denotes |
. |
T22187 |
7431-7510 |
sentence |
denotes |
We hypothesize that the target genes of mr-s might be non-photoreceptor genes. |
T22188 |
7432-7434 |
PRP |
denotes |
We |
T22189 |
7435-7446 |
VBP |
denotes |
hypothesize |
T22190 |
7447-7451 |
IN |
denotes |
that |
T22191 |
7483-7485 |
VB |
denotes |
be |
T22192 |
7452-7455 |
DT |
denotes |
the |
T22193 |
7463-7468 |
NNS |
denotes |
genes |
T22194 |
7456-7462 |
NN |
denotes |
target |
T22195 |
7469-7471 |
IN |
denotes |
of |
T22196 |
7472-7474 |
NN |
denotes |
mr |
T22197 |
7475-7476 |
NN |
denotes |
s |
T22198 |
7474-7475 |
HYPH |
denotes |
- |
T22199 |
7477-7482 |
MD |
denotes |
might |
T22200 |
7486-7503 |
JJ |
denotes |
non-photoreceptor |
T22201 |
7504-7509 |
NNS |
denotes |
genes |
T22202 |
7509-7510 |
. |
denotes |
. |
T22203 |
7510-7616 |
sentence |
denotes |
In this case, mr-s may suppress the expression of non-photoreceptor genes in rod and cone photoreceptors. |
T22204 |
7511-7513 |
IN |
denotes |
In |
T22205 |
7534-7542 |
VB |
denotes |
suppress |
T22206 |
7514-7518 |
DT |
denotes |
this |
T22207 |
7519-7523 |
NN |
denotes |
case |
T22208 |
7523-7525 |
, |
denotes |
, |
T22209 |
7525-7527 |
NN |
denotes |
mr |
T22210 |
7528-7529 |
NN |
denotes |
s |
T22211 |
7527-7528 |
HYPH |
denotes |
- |
T22212 |
7530-7533 |
MD |
denotes |
may |
T22213 |
7543-7546 |
DT |
denotes |
the |
T22214 |
7547-7557 |
NN |
denotes |
expression |
T22215 |
7558-7560 |
IN |
denotes |
of |
T22216 |
7561-7578 |
JJ |
denotes |
non-photoreceptor |
T22217 |
7579-7584 |
NNS |
denotes |
genes |
T22218 |
7585-7587 |
IN |
denotes |
in |
T22219 |
7588-7591 |
NN |
denotes |
rod |
T22220 |
7601-7615 |
NNS |
denotes |
photoreceptors |
T22221 |
7592-7595 |
CC |
denotes |
and |
T22222 |
7596-7600 |
NN |
denotes |
cone |
T22223 |
7615-7616 |
. |
denotes |
. |
T22224 |
7616-7748 |
sentence |
denotes |
There may be another possibility that mr-s is involved in cell fate determination of rod photoreceptors versus cone photoreceptors. |
T22225 |
7617-7622 |
EX |
denotes |
There |
T22226 |
7627-7629 |
VB |
denotes |
be |
T22227 |
7623-7626 |
MD |
denotes |
may |
T22228 |
7630-7637 |
DT |
denotes |
another |
T22229 |
7638-7649 |
NN |
denotes |
possibility |
T22230 |
7650-7654 |
IN |
denotes |
that |
T22231 |
7663-7671 |
VBN |
denotes |
involved |
T22232 |
7655-7657 |
NN |
denotes |
mr |
T22233 |
7658-7659 |
NN |
denotes |
s |
T22234 |
7657-7658 |
HYPH |
denotes |
- |
T22235 |
7660-7662 |
VBZ |
denotes |
is |
T22236 |
7672-7674 |
IN |
denotes |
in |
T22237 |
7675-7679 |
NN |
denotes |
cell |
T22238 |
7680-7684 |
NN |
denotes |
fate |
T22239 |
7685-7698 |
NN |
denotes |
determination |
T22240 |
7699-7701 |
IN |
denotes |
of |
T22241 |
7702-7705 |
NN |
denotes |
rod |
T22242 |
7706-7720 |
NNS |
denotes |
photoreceptors |
T22243 |
7721-7727 |
CC |
denotes |
versus |
T22244 |
7728-7732 |
NN |
denotes |
cone |
T22245 |
7733-7747 |
NNS |
denotes |
photoreceptors |
T22246 |
7747-7748 |
. |
denotes |
. |
T22247 |
7748-7934 |
sentence |
denotes |
While cone photoreceptors are born during the early embryonic stages of mouse retinogenesis, rod photoreceptors are born primarily in the late embryonic and early postnatal period [48]. |
T22248 |
7749-7754 |
IN |
denotes |
While |
T22249 |
7779-7783 |
VBN |
denotes |
born |
T22250 |
7755-7759 |
NN |
denotes |
cone |
T22251 |
7760-7774 |
NNS |
denotes |
photoreceptors |
T22252 |
7775-7778 |
VBP |
denotes |
are |
T22253 |
7865-7869 |
VBN |
denotes |
born |
T22254 |
7784-7790 |
IN |
denotes |
during |
T22255 |
7791-7794 |
DT |
denotes |
the |
T22256 |
7811-7817 |
NNS |
denotes |
stages |
T22257 |
7795-7800 |
JJ |
denotes |
early |
T22258 |
7801-7810 |
JJ |
denotes |
embryonic |
T22259 |
7818-7820 |
IN |
denotes |
of |
T22260 |
7821-7826 |
NN |
denotes |
mouse |
T22261 |
7827-7840 |
NN |
denotes |
retinogenesis |
T22262 |
7840-7842 |
, |
denotes |
, |
T22263 |
7842-7845 |
NN |
denotes |
rod |
T22264 |
7846-7860 |
NNS |
denotes |
photoreceptors |
T22265 |
7861-7864 |
VBP |
denotes |
are |
T22266 |
7870-7879 |
RB |
denotes |
primarily |
T22267 |
7880-7882 |
IN |
denotes |
in |
T22268 |
7883-7886 |
DT |
denotes |
the |
T22269 |
7922-7928 |
NN |
denotes |
period |
T22270 |
7887-7891 |
JJ |
denotes |
late |
T22271 |
7892-7901 |
JJ |
denotes |
embryonic |
T22272 |
7902-7905 |
CC |
denotes |
and |
T22273 |
7906-7911 |
JJ |
denotes |
early |
T22274 |
7912-7921 |
JJ |
denotes |
postnatal |
T22275 |
7929-7930 |
-LRB- |
denotes |
[ |
T22276 |
7930-7932 |
CD |
denotes |
48 |
T22277 |
7932-7933 |
-RRB- |
denotes |
] |
T22278 |
7933-7934 |
. |
denotes |
. |
T22279 |
7934-8184 |
sentence |
denotes |
The expression pattern of mr-s may suggest that mr-s is expressed in rod photoreceptors but not in cone photoreceptors as well as Nr2e3, which is known as a transcriptional repressor and is thought to down-regulate cone photoreceptor-specific genes. |
T22280 |
7935-7938 |
DT |
denotes |
The |
T22281 |
7950-7957 |
NN |
denotes |
pattern |
T22282 |
7939-7949 |
NN |
denotes |
expression |
T22283 |
7970-7977 |
VB |
denotes |
suggest |
T22284 |
7958-7960 |
IN |
denotes |
of |
T22285 |
7961-7963 |
NN |
denotes |
mr |
T22286 |
7964-7965 |
NN |
denotes |
s |
T22287 |
7963-7964 |
HYPH |
denotes |
- |
T22288 |
7966-7969 |
MD |
denotes |
may |
T22289 |
7978-7982 |
IN |
denotes |
that |
T22290 |
7991-8000 |
VBN |
denotes |
expressed |
T22291 |
7983-7985 |
NN |
denotes |
mr |
T22292 |
7986-7987 |
NN |
denotes |
s |
T22293 |
7985-7986 |
HYPH |
denotes |
- |
T22294 |
7988-7990 |
VBZ |
denotes |
is |
T22295 |
8001-8003 |
IN |
denotes |
in |
T22296 |
8004-8007 |
NN |
denotes |
rod |
T22297 |
8008-8022 |
NNS |
denotes |
photoreceptors |
T22298 |
8023-8026 |
CC |
denotes |
but |
T22299 |
8027-8030 |
RB |
denotes |
not |
T22300 |
8031-8033 |
IN |
denotes |
in |
T22301 |
8034-8038 |
NN |
denotes |
cone |
T22302 |
8039-8053 |
NNS |
denotes |
photoreceptors |
T22303 |
8054-8056 |
RB |
denotes |
as |
T22304 |
8062-8064 |
IN |
denotes |
as |
T22305 |
8057-8061 |
RB |
denotes |
well |
T22306 |
8065-8070 |
NN |
denotes |
Nr2e3 |
T22307 |
8070-8072 |
, |
denotes |
, |
T22308 |
8072-8077 |
WDT |
denotes |
which |
T22309 |
8081-8086 |
VBN |
denotes |
known |
T22310 |
8078-8080 |
VBZ |
denotes |
is |
T22311 |
8087-8089 |
IN |
denotes |
as |
T22312 |
8090-8091 |
DT |
denotes |
a |
T22313 |
8108-8117 |
NN |
denotes |
repressor |
T22314 |
8092-8107 |
JJ |
denotes |
transcriptional |
T22315 |
8118-8121 |
CC |
denotes |
and |
T22316 |
8122-8124 |
VBZ |
denotes |
is |
T22317 |
8125-8132 |
VBN |
denotes |
thought |
T22318 |
8133-8135 |
TO |
denotes |
to |
T22319 |
8141-8149 |
VB |
denotes |
regulate |
T22320 |
8136-8140 |
RB |
denotes |
down |
T22321 |
8140-8141 |
HYPH |
denotes |
- |
T22322 |
8150-8154 |
NN |
denotes |
cone |
T22323 |
8178-8183 |
NNS |
denotes |
genes |
T22324 |
8155-8168 |
NN |
denotes |
photoreceptor |
T22325 |
8169-8177 |
JJ |
denotes |
specific |
T22326 |
8168-8169 |
HYPH |
denotes |
- |
T22327 |
8183-8184 |
. |
denotes |
. |
T22328 |
8184-8303 |
sentence |
denotes |
To clarify the biological function of mr-s, analysis of mice with targeted disruptions of mr-s will be very important. |
T22329 |
8185-8187 |
TO |
denotes |
To |
T22330 |
8188-8195 |
VB |
denotes |
clarify |
T22331 |
8285-8287 |
VB |
denotes |
be |
T22332 |
8196-8199 |
DT |
denotes |
the |
T22333 |
8211-8219 |
NN |
denotes |
function |
T22334 |
8200-8210 |
JJ |
denotes |
biological |
T22335 |
8220-8222 |
IN |
denotes |
of |
T22336 |
8223-8225 |
NN |
denotes |
mr |
T22337 |
8226-8227 |
NN |
denotes |
s |
T22338 |
8225-8226 |
HYPH |
denotes |
- |
T22339 |
8227-8229 |
, |
denotes |
, |
T22340 |
8229-8237 |
NN |
denotes |
analysis |
T22341 |
8238-8240 |
IN |
denotes |
of |
T22342 |
8241-8245 |
NNS |
denotes |
mice |
T22343 |
8246-8250 |
IN |
denotes |
with |
T22344 |
8251-8259 |
VBN |
denotes |
targeted |
T22345 |
8260-8271 |
NNS |
denotes |
disruptions |
T22346 |
8272-8274 |
IN |
denotes |
of |
T22347 |
8275-8277 |
NN |
denotes |
mr |
T22348 |
8278-8279 |
NN |
denotes |
s |
T22349 |
8277-8278 |
HYPH |
denotes |
- |
T22350 |
8280-8284 |
MD |
denotes |
will |
T22351 |
8288-8292 |
RB |
denotes |
very |
T22352 |
8293-8302 |
JJ |
denotes |
important |
T22353 |
8302-8303 |
. |
denotes |
. |
R4875 |
T20693 |
T20694 |
prep |
In,identified |
R4876 |
T20695 |
T20696 |
det |
the,study |
R4877 |
T20696 |
T20693 |
pobj |
study,In |
R4878 |
T20697 |
T20696 |
amod |
present,study |
R4879 |
T20698 |
T20694 |
punct |
", ",identified |
R4880 |
T20699 |
T20694 |
nsubj |
we,identified |
R4881 |
T20700 |
T20701 |
det |
a,gene |
R4882 |
T20701 |
T20694 |
dobj |
gene,identified |
R4883 |
T20702 |
T20701 |
amod |
novel,gene |
R4884 |
T20703 |
T20701 |
punct |
", ",gene |
R4885 |
T20704 |
T20705 |
compound |
mr,s |
R4886 |
T20705 |
T20701 |
appos |
s,gene |
R4887 |
T20706 |
T20705 |
punct |
-,s |
R4888 |
T20707 |
T20701 |
punct |
", ",gene |
R4889 |
T20708 |
T20709 |
dep |
which,expressed |
R4890 |
T20709 |
T20701 |
relcl |
expressed,gene |
R4891 |
T20710 |
T20709 |
auxpass |
is,expressed |
R4892 |
T20711 |
T20709 |
advmod |
predominantly,expressed |
R4893 |
T20712 |
T20709 |
prep |
in,expressed |
R4894 |
T20713 |
T20714 |
amod |
retinal,photoreceptors |
R4895 |
T20714 |
T20712 |
pobj |
photoreceptors,in |
R4896 |
T20715 |
T20714 |
cc |
and,photoreceptors |
R4897 |
T20716 |
T20717 |
det |
the,gland |
R4898 |
T20717 |
T20714 |
conj |
gland,photoreceptors |
R4899 |
T20718 |
T20717 |
amod |
pineal,gland |
R4900 |
T20719 |
T20694 |
punct |
.,identified |
R4901 |
T20721 |
T20722 |
det |
The,peak |
R4902 |
T20722 |
T20723 |
nsubj |
peak,is |
R4903 |
T20724 |
T20722 |
prep |
of,peak |
R4904 |
T20725 |
T20726 |
compound |
mr,s |
R4905 |
T20726 |
T20728 |
compound |
s,expression |
R4906 |
T20727 |
T20726 |
punct |
-,s |
R4907 |
T20728 |
T20724 |
pobj |
expression,of |
R4908 |
T20729 |
T20728 |
prep |
in,expression |
R4909 |
T20730 |
T20731 |
det |
the,retina |
R4910 |
T20731 |
T20729 |
pobj |
retina,in |
R4911 |
T20732 |
T20731 |
amod |
developing,retina |
R4912 |
T20733 |
T20723 |
prep |
around,is |
R4913 |
T20734 |
T20733 |
pobj |
P6,around |
R4914 |
T20735 |
T20723 |
punct |
.,is |
R4915 |
T20737 |
T20738 |
det |
This,pattern |
R4916 |
T20738 |
T20740 |
nsubj |
pattern,correlates |
R4917 |
T20739 |
T20738 |
compound |
expression,pattern |
R4918 |
T20741 |
T20740 |
prep |
with,correlates |
R4919 |
T20742 |
T20743 |
det |
the,increase |
R4920 |
T20743 |
T20741 |
pobj |
increase,with |
R4921 |
T20744 |
T20743 |
amod |
rapid,increase |
R4922 |
T20745 |
T20743 |
prep |
of,increase |
R4923 |
T20746 |
T20745 |
pobj |
Crx,of |
R4924 |
T20747 |
T20746 |
punct |
", ",Crx |
R4925 |
T20748 |
T20746 |
conj |
rhodopsin,Crx |
R4926 |
T20749 |
T20748 |
cc |
and,rhodopsin |
R4927 |
T20750 |
T20751 |
amod |
other,genes |
R4928 |
T20751 |
T20748 |
conj |
genes,rhodopsin |
R4929 |
T20752 |
T20751 |
compound |
photoreceptor,genes |
R4930 |
T20753 |
T20743 |
prep |
around,increase |
R4931 |
T20754 |
T20753 |
pobj |
P6,around |
R4932 |
T20755 |
T20756 |
punct |
-,P8 |
R4933 |
T20756 |
T20754 |
prep |
P8,P6 |
R4934 |
T20757 |
T20740 |
punct |
.,correlates |
R4935 |
T20759 |
T20760 |
prep |
Around,becomes |
R4936 |
T20761 |
T20759 |
pobj |
P6,Around |
R4937 |
T20762 |
T20760 |
punct |
", ",becomes |
R4938 |
T20763 |
T20764 |
det |
the,layer |
R4939 |
T20764 |
T20760 |
nsubj |
layer,becomes |
R4940 |
T20765 |
T20764 |
amod |
outer,layer |
R4941 |
T20766 |
T20764 |
compound |
plexiform,layer |
R4942 |
T20767 |
T20760 |
acomp |
visible,becomes |
R4943 |
T20768 |
T20760 |
cc |
and,becomes |
R4944 |
T20769 |
T20770 |
det |
the,layer |
R4945 |
T20770 |
T20772 |
nsubj |
layer,separates |
R4946 |
T20771 |
T20770 |
amod |
outer,layer |
R4947 |
T20772 |
T20760 |
conj |
separates,becomes |
R4948 |
T20773 |
T20770 |
prep |
of,layer |
R4949 |
T20774 |
T20773 |
pobj |
retina,of |
R4950 |
T20775 |
T20772 |
prep |
into,separates |
R4951 |
T20776 |
T20777 |
nummod |
two,layers |
R4952 |
T20777 |
T20775 |
pobj |
layers,into |
R4953 |
T20778 |
T20777 |
punct |
", ",layers |
R4954 |
T20779 |
T20777 |
appos |
ONL,layers |
R4955 |
T20780 |
T20779 |
cc |
and,ONL |
R4956 |
T20781 |
T20779 |
conj |
INL,ONL |
R4957 |
T20782 |
T20760 |
punct |
.,becomes |
R4958 |
T20784 |
T20785 |
prep |
At,begin |
R4959 |
T20786 |
T20787 |
det |
the,time |
R4960 |
T20787 |
T20784 |
pobj |
time,At |
R4961 |
T20788 |
T20787 |
amod |
same,time |
R4962 |
T20789 |
T20785 |
punct |
", ",begin |
R4963 |
T20790 |
T20785 |
nsubj |
photoreceptors,begin |
R4964 |
T20791 |
T20792 |
aux |
to,undergo |
R4965 |
T20792 |
T20785 |
xcomp |
undergo,begin |
R4966 |
T20793 |
T20794 |
amod |
terminal,differentiation |
R4967 |
T20794 |
T20792 |
dobj |
differentiation,undergo |
R4968 |
T20795 |
T20792 |
punct |
", ",undergo |
R4969 |
T20796 |
T20792 |
advcl |
forming,undergo |
R4970 |
T20797 |
T20798 |
det |
the,segment |
R4971 |
T20798 |
T20796 |
dobj |
segment,forming |
R4972 |
T20799 |
T20798 |
amod |
outer,segment |
R4973 |
T20800 |
T20785 |
punct |
.,begin |
R4974 |
T20802 |
T20803 |
nsubj |
We,hypothesized |
R4975 |
T20804 |
T20803 |
advmod |
therefore,hypothesized |
R4976 |
T20805 |
T20806 |
mark |
that,is |
R4977 |
T20806 |
T20803 |
ccomp |
is,hypothesized |
R4978 |
T20807 |
T20808 |
compound |
mr,s |
R4979 |
T20808 |
T20806 |
nsubj |
s,is |
R4980 |
T20809 |
T20808 |
punct |
-,s |
R4981 |
T20810 |
T20811 |
det |
a,molecule |
R4982 |
T20811 |
T20806 |
attr |
molecule,is |
R4983 |
T20812 |
T20811 |
amod |
key,molecule |
R4984 |
T20813 |
T20811 |
prep |
in,molecule |
R4985 |
T20814 |
T20815 |
det |
the,development |
R4986 |
T20815 |
T20813 |
pobj |
development,in |
R4987 |
T20816 |
T20815 |
amod |
late,development |
R4988 |
T20817 |
T20815 |
prep |
of,development |
R4989 |
T20818 |
T20817 |
pobj |
photoreceptors,of |
R4990 |
T20819 |
T20803 |
punct |
.,hypothesized |
R4991 |
T20821 |
T20822 |
nsubj |
We,reported |
R4992 |
T20823 |
T20822 |
advmod |
previously,reported |
R4993 |
T20824 |
T20825 |
mark |
that,have |
R4994 |
T20825 |
T20822 |
advcl |
have,reported |
R4995 |
T20826 |
T20825 |
nsubj |
Otx2,have |
R4996 |
T20827 |
T20826 |
cc |
and,Otx2 |
R4997 |
T20828 |
T20826 |
conj |
Crx,Otx2 |
R4998 |
T20829 |
T20830 |
det |
a,role |
R4999 |
T20830 |
T20825 |
dobj |
role,have |
R5000 |
T20831 |
T20830 |
amod |
critical,role |
R5001 |
T20832 |
T20830 |
prep |
in,role |
R5002 |
T20833 |
T20834 |
compound |
photoreceptor,development |
R5003 |
T20834 |
T20832 |
pobj |
development,in |
R5004 |
T20835 |
T20825 |
cc |
and,have |
R5005 |
T20836 |
T20837 |
mark |
that,regulates |
R5006 |
T20837 |
T20825 |
conj |
regulates,have |
R5007 |
T20838 |
T20837 |
nsubj |
Otx2,regulates |
R5008 |
T20839 |
T20837 |
advmod |
directly,regulates |
R5009 |
T20840 |
T20841 |
compound |
Crx,transcription |
R5010 |
T20841 |
T20837 |
dobj |
transcription,regulates |
R5011 |
T20842 |
T20843 |
punct |
[,9 |
R5012 |
T20843 |
T20822 |
parataxis |
9,reported |
R5013 |
T20844 |
T20843 |
nummod |
3,9 |
R5014 |
T20845 |
T20843 |
punct |
",",9 |
R5015 |
T20846 |
T20843 |
punct |
],9 |
R5016 |
T20847 |
T20822 |
punct |
.,reported |
R5017 |
T20849 |
T20850 |
advmod |
In,situ |
R5018 |
T20850 |
T20851 |
amod |
situ,hybridization |
R5019 |
T20851 |
T20852 |
nsubj |
hybridization,showed |
R5020 |
T20853 |
T20851 |
cc |
and,hybridization |
R5021 |
T20854 |
T20855 |
compound |
RT,PCR |
R5022 |
T20855 |
T20851 |
conj |
PCR,hybridization |
R5023 |
T20856 |
T20855 |
punct |
-,PCR |
R5024 |
T20857 |
T20858 |
amod |
significant,reduction |
R5025 |
T20858 |
T20852 |
dobj |
reduction,showed |
R5026 |
T20859 |
T20858 |
prep |
of,reduction |
R5027 |
T20860 |
T20861 |
compound |
mr,s |
R5028 |
T20861 |
T20863 |
compound |
s,signal |
R5029 |
T20862 |
T20861 |
punct |
-,s |
R5030 |
T20863 |
T20859 |
pobj |
signal,of |
R5031 |
T20864 |
T20852 |
prep |
in,showed |
R5032 |
T20865 |
T20866 |
det |
the,KO |
R5033 |
T20866 |
T20864 |
pobj |
KO,in |
R5034 |
T20867 |
T20866 |
compound |
Crx,KO |
R5035 |
T20868 |
T20866 |
appos |
retina,KO |
R5036 |
T20869 |
T20868 |
cc |
and,retina |
R5037 |
T20870 |
T20871 |
amod |
pineal,gland |
R5038 |
T20871 |
T20868 |
conj |
gland,retina |
R5039 |
T20872 |
T20852 |
punct |
.,showed |
R5040 |
T20874 |
T20875 |
advmod |
Furthermore,demonstrated |
R5041 |
T20876 |
T20875 |
punct |
", ",demonstrated |
R5042 |
T20877 |
T20878 |
det |
the,assay |
R5043 |
T20878 |
T20875 |
nsubj |
assay,demonstrated |
R5044 |
T20879 |
T20878 |
compound |
luciferase,assay |
R5045 |
T20880 |
T20881 |
mark |
that,upregulate |
R5046 |
T20881 |
T20875 |
ccomp |
upregulate,demonstrated |
R5047 |
T20882 |
T20881 |
nsubj |
Otx2,upregulate |
R5048 |
T20883 |
T20882 |
cc |
and,Otx2 |
R5049 |
T20884 |
T20882 |
conj |
Crx,Otx2 |
R5050 |
T20885 |
T20881 |
aux |
may,upregulate |
R5051 |
T20886 |
T20881 |
advmod |
directly,upregulate |
R5052 |
T20887 |
T20888 |
det |
the,transcription |
R5053 |
T20888 |
T20881 |
dobj |
transcription,upregulate |
R5054 |
T20889 |
T20888 |
prep |
of,transcription |
R5055 |
T20890 |
T20891 |
compound |
mr,s |
R5056 |
T20891 |
T20889 |
pobj |
s,of |
R5057 |
T20892 |
T20891 |
punct |
-,s |
R5058 |
T20893 |
T20881 |
prep |
in,upregulate |
R5059 |
T20894 |
T20895 |
amod |
mammalian,cells |
R5060 |
T20895 |
T20893 |
pobj |
cells,in |
R5061 |
T20896 |
T20875 |
punct |
.,demonstrated |
R5062 |
T20898 |
T20899 |
prep |
In,are |
R5063 |
T20900 |
T20901 |
amod |
retinal,cells |
R5064 |
T20901 |
T20898 |
pobj |
cells,In |
R5065 |
T20902 |
T20901 |
compound |
photoreceptor,cells |
R5066 |
T20903 |
T20899 |
punct |
", ",are |
R5067 |
T20904 |
T20905 |
det |
the,transcripts |
R5068 |
T20905 |
T20899 |
nsubj |
transcripts,are |
R5069 |
T20906 |
T20905 |
compound |
Otx2,transcripts |
R5070 |
T20907 |
T20899 |
neg |
not,are |
R5071 |
T20908 |
T20909 |
advmod |
highly,expressed |
R5072 |
T20909 |
T20899 |
acomp |
expressed,are |
R5073 |
T20910 |
T20899 |
prep |
at,are |
R5074 |
T20911 |
T20910 |
pobj |
P6,at |
R5075 |
T20912 |
T20913 |
punct |
-,P9 |
R5076 |
T20913 |
T20911 |
prep |
P9,P6 |
R5077 |
T20914 |
T20899 |
punct |
", ",are |
R5078 |
T20915 |
T20916 |
mark |
while,detected |
R5079 |
T20916 |
T20899 |
advcl |
detected,are |
R5080 |
T20917 |
T20918 |
det |
the,transcripts |
R5081 |
T20918 |
T20916 |
nsubjpass |
transcripts,detected |
R5082 |
T20919 |
T20918 |
compound |
Crx,transcripts |
R5083 |
T20920 |
T20916 |
auxpass |
are,detected |
R5084 |
T20921 |
T20916 |
advmod |
strongly,detected |
R5085 |
T20922 |
T20916 |
prep |
around,detected |
R5086 |
T20923 |
T20922 |
pobj |
P6,around |
R5087 |
T20924 |
T20899 |
punct |
.,are |
R5088 |
T20926 |
T20927 |
advmod |
Therefore,suggest |
R5089 |
T20928 |
T20927 |
punct |
", ",suggest |
R5090 |
T20929 |
T20930 |
poss |
our,results |
R5091 |
T20930 |
T20927 |
nsubj |
results,suggest |
R5092 |
T20931 |
T20927 |
advmod |
strongly,suggest |
R5093 |
T20932 |
T20933 |
mark |
that,regulated |
R5094 |
T20933 |
T20927 |
ccomp |
regulated,suggest |
R5095 |
T20934 |
T20935 |
compound |
mr,s |
R5096 |
T20935 |
T20937 |
compound |
s,transcription |
R5097 |
T20936 |
T20935 |
punct |
-,s |
R5098 |
T20937 |
T20933 |
nsubjpass |
transcription,regulated |
R5099 |
T20938 |
T20933 |
auxpass |
is,regulated |
R5100 |
T20939 |
T20933 |
advmod |
directly,regulated |
R5101 |
T20940 |
T20933 |
agent |
by,regulated |
R5102 |
T20941 |
T20940 |
pobj |
Crx,by |
R5103 |
T20942 |
T20927 |
punct |
.,suggest |
R5104 |
T20944 |
T20945 |
prep |
In,affect |
R5105 |
T20946 |
T20947 |
det |
the,study |
R5106 |
T20947 |
T20944 |
pobj |
study,In |
R5107 |
T20948 |
T20947 |
amod |
present,study |
R5108 |
T20949 |
T20945 |
punct |
", ",affect |
R5109 |
T20950 |
T20945 |
nsubj |
Nrl,affect |
R5110 |
T20951 |
T20950 |
punct |
", ",Nrl |
R5111 |
T20952 |
T20953 |
det |
a,factor |
R5112 |
T20953 |
T20950 |
appos |
factor,Nrl |
R5113 |
T20954 |
T20955 |
npadvmod |
photoreceptor,specific |
R5114 |
T20955 |
T20953 |
amod |
specific,factor |
R5115 |
T20956 |
T20955 |
punct |
-,specific |
R5116 |
T20957 |
T20953 |
compound |
transcription,factor |
R5117 |
T20958 |
T20959 |
dep |
that,expressed |
R5118 |
T20959 |
T20953 |
relcl |
expressed,factor |
R5119 |
T20960 |
T20959 |
auxpass |
is,expressed |
R5120 |
T20961 |
T20959 |
advmod |
highly,expressed |
R5121 |
T20962 |
T20959 |
prep |
in,expressed |
R5122 |
T20963 |
T20962 |
pobj |
photoreceptors,in |
R5123 |
T20964 |
T20959 |
prep |
at,expressed |
R5124 |
T20965 |
T20966 |
det |
the,stage |
R5125 |
T20966 |
T20964 |
pobj |
stage,at |
R5126 |
T20967 |
T20966 |
amod |
postnatal,stage |
R5127 |
T20968 |
T20945 |
punct |
", ",affect |
R5128 |
T20969 |
T20945 |
aux |
did,affect |
R5129 |
T20970 |
T20945 |
neg |
not,affect |
R5130 |
T20971 |
T20972 |
det |
the,transcription |
R5131 |
T20972 |
T20945 |
dobj |
transcription,affect |
R5132 |
T20973 |
T20972 |
prep |
of,transcription |
R5133 |
T20974 |
T20975 |
compound |
mr,s |
R5134 |
T20975 |
T20973 |
pobj |
s,of |
R5135 |
T20976 |
T20975 |
punct |
-,s |
R5136 |
T20977 |
T20945 |
punct |
.,affect |
R5137 |
T20979 |
T20980 |
det |
This,finding |
R5138 |
T20980 |
T20981 |
nsubj |
finding,is |
R5139 |
T20982 |
T20981 |
advmod |
actually,is |
R5140 |
T20983 |
T20981 |
acomp |
consistent,is |
R5141 |
T20984 |
T20983 |
prep |
with,consistent |
R5142 |
T20985 |
T20986 |
det |
the,analysis |
R5143 |
T20986 |
T20984 |
pobj |
analysis,with |
R5144 |
T20987 |
T20986 |
prep |
of,analysis |
R5145 |
T20988 |
T20989 |
det |
the,mouse |
R5146 |
T20989 |
T20987 |
pobj |
mouse,of |
R5147 |
T20990 |
T20991 |
compound |
Nrl,KO |
R5148 |
T20991 |
T20989 |
compound |
KO,mouse |
R5149 |
T20992 |
T20993 |
dep |
which,reported |
R5150 |
T20993 |
T20989 |
relcl |
reported,mouse |
R5151 |
T20994 |
T20993 |
auxpass |
was,reported |
R5152 |
T20995 |
T20993 |
advmod |
recently,reported |
R5153 |
T20996 |
T20997 |
punct |
[,40 |
R5154 |
T20997 |
T20981 |
parataxis |
40,is |
R5155 |
T20998 |
T20997 |
punct |
],40 |
R5156 |
T20999 |
T20981 |
punct |
.,is |
R5157 |
T21001 |
T21002 |
det |
The,profiles |
R5158 |
T21002 |
T21004 |
nsubjpass |
profiles,analyzed |
R5159 |
T21003 |
T21002 |
compound |
expression,profiles |
R5160 |
T21005 |
T21002 |
prep |
of,profiles |
R5161 |
T21006 |
T21007 |
amod |
wild,type |
R5162 |
T21007 |
T21009 |
nmod |
type,retinas |
R5163 |
T21008 |
T21007 |
punct |
-,type |
R5164 |
T21009 |
T21005 |
pobj |
retinas,of |
R5165 |
T21010 |
T21007 |
cc |
and,type |
R5166 |
T21011 |
T21012 |
compound |
Nrl,KO |
R5167 |
T21012 |
T21007 |
conj |
KO,type |
R5168 |
T21013 |
T21002 |
prep |
at,profiles |
R5169 |
T21014 |
T21013 |
pobj |
P2,at |
R5170 |
T21015 |
T21014 |
punct |
", ",P2 |
R5171 |
T21016 |
T21014 |
conj |
P10,P2 |
R5172 |
T21017 |
T21016 |
cc |
and,P10 |
R5173 |
T21018 |
T21019 |
nummod |
2,months |
R5174 |
T21019 |
T21016 |
conj |
months,P10 |
R5175 |
T21020 |
T21004 |
auxpass |
were,analyzed |
R5176 |
T21021 |
T21004 |
cc |
and,analyzed |
R5177 |
T21022 |
T21023 |
compound |
mr,s |
R5178 |
T21023 |
T21025 |
nsubjpass |
s,included |
R5179 |
T21024 |
T21023 |
punct |
-,s |
R5180 |
T21025 |
T21004 |
conj |
included,analyzed |
R5181 |
T21026 |
T21025 |
auxpass |
was,included |
R5182 |
T21027 |
T21025 |
neg |
not,included |
R5183 |
T21028 |
T21025 |
prep |
in,included |
R5184 |
T21029 |
T21030 |
nummod |
161,genes |
R5185 |
T21030 |
T21028 |
pobj |
genes,in |
R5186 |
T21031 |
T21032 |
advmod |
differentially,expressed |
R5187 |
T21032 |
T21030 |
amod |
expressed,genes |
R5188 |
T21033 |
T21025 |
prep |
in,included |
R5189 |
T21034 |
T21035 |
det |
the,retina |
R5190 |
T21035 |
T21033 |
pobj |
retina,in |
R5191 |
T21036 |
T21037 |
compound |
Nrl,KO |
R5192 |
T21037 |
T21035 |
compound |
KO,retina |
R5193 |
T21038 |
T21025 |
punct |
.,included |
R5194 |
T21040 |
T21041 |
amod |
Previous,reports |
R5195 |
T21041 |
T21042 |
nsubj |
reports,suggested |
R5196 |
T21043 |
T21044 |
mark |
that,is |
R5197 |
T21044 |
T21042 |
ccomp |
is,suggested |
R5198 |
T21045 |
T21046 |
det |
the,domain |
R5199 |
T21046 |
T21044 |
nsubj |
domain,is |
R5200 |
T21047 |
T21046 |
compound |
SAM,domain |
R5201 |
T21048 |
T21049 |
det |
a,module |
R5202 |
T21049 |
T21044 |
attr |
module,is |
R5203 |
T21050 |
T21051 |
compound |
protein,protein |
R5204 |
T21051 |
T21049 |
compound |
protein,module |
R5205 |
T21052 |
T21051 |
punct |
-,protein |
R5206 |
T21053 |
T21049 |
compound |
interaction,module |
R5207 |
T21054 |
T21042 |
punct |
.,suggested |
R5208 |
T21056 |
T21057 |
det |
The,domain |
R5209 |
T21057 |
T21059 |
nsubjpass |
domain,related |
R5210 |
T21058 |
T21057 |
compound |
SAM,domain |
R5211 |
T21060 |
T21057 |
prep |
of,domain |
R5212 |
T21061 |
T21062 |
det |
the,protein |
R5213 |
T21062 |
T21060 |
pobj |
protein,of |
R5214 |
T21063 |
T21064 |
compound |
mr,s |
R5215 |
T21064 |
T21062 |
compound |
s,protein |
R5216 |
T21065 |
T21064 |
punct |
-,s |
R5217 |
T21066 |
T21059 |
auxpass |
is,related |
R5218 |
T21067 |
T21059 |
advmod |
closely,related |
R5219 |
T21068 |
T21059 |
prep |
to,related |
R5220 |
T21069 |
T21068 |
pobj |
that,to |
R5221 |
T21070 |
T21069 |
prep |
of,that |
R5222 |
T21071 |
T21070 |
pobj |
ph,of |
R5223 |
T21072 |
T21071 |
cc |
and,ph |
R5224 |
T21073 |
T21071 |
conj |
TEL,ph |
R5225 |
T21074 |
T21071 |
punct |
", ",ph |
R5226 |
T21075 |
T21076 |
poss |
whose,domains |
R5227 |
T21076 |
T21078 |
dep |
domains,form |
R5228 |
T21077 |
T21076 |
compound |
SAM,domains |
R5229 |
T21078 |
T21071 |
relcl |
form,ph |
R5230 |
T21079 |
T21078 |
aux |
can,form |
R5231 |
T21080 |
T21081 |
det |
a,structure |
R5232 |
T21081 |
T21078 |
dobj |
structure,form |
R5233 |
T21082 |
T21081 |
amod |
helical,structure |
R5234 |
T21083 |
T21081 |
punct |
", ",structure |
R5235 |
T21084 |
T21081 |
nmod |
head,structure |
R5236 |
T21085 |
T21084 |
punct |
-,head |
R5237 |
T21086 |
T21084 |
prep |
to,head |
R5238 |
T21087 |
T21086 |
punct |
-,to |
R5239 |
T21088 |
T21086 |
pobj |
tail,to |
R5240 |
T21089 |
T21081 |
amod |
polymeric,structure |
R5241 |
T21090 |
T21078 |
cc |
and,form |
R5242 |
T21091 |
T21078 |
conj |
mediate,form |
R5243 |
T21092 |
T21093 |
det |
the,formation |
R5244 |
T21093 |
T21091 |
dobj |
formation,mediate |
R5245 |
T21094 |
T21093 |
prep |
of,formation |
R5246 |
T21095 |
T21096 |
det |
a,structure |
R5247 |
T21096 |
T21094 |
pobj |
structure,of |
R5248 |
T21097 |
T21098 |
amod |
higher,order |
R5249 |
T21098 |
T21096 |
compound |
order,structure |
R5250 |
T21099 |
T21096 |
compound |
chromatin,structure |
R5251 |
T21100 |
T21059 |
punct |
.,related |
R5252 |
T21102 |
T21103 |
aux |
To,characterize |
R5253 |
T21103 |
T21104 |
advcl |
characterize,performed |
R5254 |
T21105 |
T21106 |
det |
the,function |
R5255 |
T21106 |
T21103 |
dobj |
function,characterize |
R5256 |
T21107 |
T21106 |
amod |
biochemical,function |
R5257 |
T21108 |
T21106 |
prep |
of,function |
R5258 |
T21109 |
T21110 |
compound |
mr,s |
R5259 |
T21110 |
T21108 |
pobj |
s,of |
R5260 |
T21111 |
T21110 |
punct |
-,s |
R5261 |
T21112 |
T21104 |
punct |
", ",performed |
R5262 |
T21113 |
T21104 |
nsubj |
we,performed |
R5263 |
T21114 |
T21115 |
nmod |
yeast,screening |
R5264 |
T21115 |
T21104 |
dobj |
screening,performed |
R5265 |
T21116 |
T21117 |
nummod |
two,hybrid |
R5266 |
T21117 |
T21115 |
compound |
hybrid,screening |
R5267 |
T21118 |
T21117 |
punct |
-,hybrid |
R5268 |
T21119 |
T21104 |
advcl |
using,performed |
R5269 |
T21120 |
T21121 |
amod |
full,length |
R5270 |
T21121 |
T21123 |
compound |
length,s |
R5271 |
T21122 |
T21121 |
punct |
-,length |
R5272 |
T21123 |
T21119 |
dobj |
s,using |
R5273 |
T21124 |
T21123 |
compound |
mr,s |
R5274 |
T21125 |
T21123 |
punct |
-,s |
R5275 |
T21126 |
T21119 |
prep |
as,using |
R5276 |
T21127 |
T21128 |
det |
the,bait |
R5277 |
T21128 |
T21126 |
pobj |
bait,as |
R5278 |
T21129 |
T21104 |
punct |
.,performed |
R5279 |
T21131 |
T21132 |
prep |
As,were |
R5280 |
T21133 |
T21134 |
det |
a,result |
R5281 |
T21134 |
T21131 |
pobj |
result,As |
R5282 |
T21135 |
T21132 |
punct |
", ",were |
R5283 |
T21136 |
T21137 |
det |
the,clones |
R5284 |
T21137 |
T21132 |
nsubj |
clones,were |
R5285 |
T21138 |
T21139 |
advmod |
most,frequent |
R5286 |
T21139 |
T21137 |
amod |
frequent,clones |
R5287 |
T21140 |
T21137 |
amod |
positive,clones |
R5288 |
T21141 |
T21142 |
punct |
(,5 |
R5289 |
T21142 |
T21137 |
parataxis |
5,clones |
R5290 |
T21143 |
T21144 |
punct |
/,28 |
R5291 |
T21144 |
T21142 |
prep |
28,5 |
R5292 |
T21145 |
T21142 |
punct |
),5 |
R5293 |
T21146 |
T21137 |
prep |
in,clones |
R5294 |
T21147 |
T21148 |
det |
the,screening |
R5295 |
T21148 |
T21146 |
pobj |
screening,in |
R5296 |
T21173 |
T21174 |
poss |
its,domain |
R5297 |
T21149 |
T21150 |
det |
the,fragments |
R5298 |
T21174 |
T21172 |
pobj |
domain,through |
R5299 |
T21150 |
T21132 |
attr |
fragments,were |
R5300 |
T21175 |
T21174 |
compound |
SAM,domain |
R5301 |
T21176 |
T21163 |
punct |
.,suggests |
R5302 |
T21151 |
T21150 |
compound |
cDNA,fragments |
R5303 |
T21178 |
T21179 |
det |
An,assay |
R5304 |
T21152 |
T21150 |
acl |
containing,fragments |
R5305 |
T21179 |
T21181 |
nsubj |
assay,demonstrated |
R5306 |
T21180 |
T21179 |
compound |
immunoprecipitation,assay |
R5307 |
T21153 |
T21154 |
det |
the,domain |
R5308 |
T21182 |
T21179 |
punct |
", ",assay |
R5309 |
T21154 |
T21152 |
dobj |
domain,containing |
R5310 |
T21183 |
T21179 |
acl |
using,assay |
R5311 |
T21184 |
T21185 |
nummod |
two,mutants |
R5312 |
T21185 |
T21183 |
dobj |
mutants,using |
R5313 |
T21155 |
T21154 |
compound |
SAM,domain |
R5314 |
T21186 |
T21187 |
npadvmod |
site,directed |
R5315 |
T21187 |
T21185 |
amod |
directed,mutants |
R5316 |
T21188 |
T21187 |
punct |
-,directed |
R5317 |
T21156 |
T21154 |
prep |
of,domain |
R5318 |
T21189 |
T21185 |
prep |
of,mutants |
R5319 |
T21190 |
T21191 |
det |
the,domain |
R5320 |
T21157 |
T21158 |
compound |
mr,s |
R5321 |
T21191 |
T21189 |
pobj |
domain,of |
R5322 |
T21192 |
T21191 |
compound |
SAM,domain |
R5323 |
T21193 |
T21191 |
prep |
of,domain |
R5324 |
T21158 |
T21156 |
pobj |
s,of |
R5325 |
T21194 |
T21195 |
compound |
mr,s |
R5326 |
T21195 |
T21193 |
pobj |
s,of |
R5327 |
T21159 |
T21158 |
punct |
-,s |
R5328 |
T21196 |
T21195 |
punct |
-,s |
R5329 |
T21160 |
T21132 |
punct |
.,were |
R5330 |
T21162 |
T21163 |
nsubj |
This,suggests |
R5331 |
T21197 |
T21181 |
punct |
", ",demonstrated |
R5332 |
T21198 |
T21199 |
mark |
that,associate |
R5333 |
T21164 |
T21163 |
advmod |
strongly,suggests |
R5334 |
T21199 |
T21181 |
ccomp |
associate,demonstrated |
R5335 |
T21200 |
T21201 |
det |
the,protein |
R5336 |
T21201 |
T21199 |
nsubj |
protein,associate |
R5337 |
T21202 |
T21203 |
compound |
mr,s |
R5338 |
T21203 |
T21201 |
compound |
s,protein |
R5339 |
T21165 |
T21166 |
mark |
that,associates |
R5340 |
T21204 |
T21203 |
punct |
-,s |
R5341 |
T21166 |
T21163 |
ccomp |
associates,suggests |
R5342 |
T21205 |
T21199 |
aux |
can,associate |
R5343 |
T21206 |
T21199 |
dep |
self,associate |
R5344 |
T21207 |
T21199 |
punct |
-,associate |
R5345 |
T21208 |
T21199 |
prep |
through,associate |
R5346 |
T21209 |
T21210 |
poss |
its,domain |
R5347 |
T21167 |
T21168 |
compound |
mr,s |
R5348 |
T21210 |
T21208 |
pobj |
domain,through |
R5349 |
T21211 |
T21210 |
compound |
SAM,domain |
R5350 |
T21168 |
T21166 |
nsubj |
s,associates |
R5351 |
T21212 |
T21199 |
prep |
in,associate |
R5352 |
T21213 |
T21214 |
amod |
mammalian,cells |
R5353 |
T21214 |
T21212 |
pobj |
cells,in |
R5354 |
T21169 |
T21168 |
punct |
-,s |
R5355 |
T21215 |
T21181 |
punct |
.,demonstrated |
R5356 |
T21170 |
T21166 |
dep |
self,associates |
R5357 |
T21217 |
T21218 |
mark |
While,address |
R5358 |
T21218 |
T21222 |
advcl |
address,suggests |
R5359 |
T21171 |
T21166 |
punct |
-,associates |
R5360 |
T21219 |
T21218 |
nsubj |
we,address |
R5361 |
T21220 |
T21218 |
aux |
did,address |
R5362 |
T21221 |
T21218 |
neg |
not,address |
R5363 |
T21172 |
T21166 |
prep |
through,associates |
R5364 |
T21223 |
T21224 |
det |
the,question |
R5365 |
T21224 |
T21218 |
dobj |
question,address |
R5366 |
T21279 |
T21276 |
prep |
along,spreading |
R5367 |
T21225 |
T21226 |
mark |
whether,forms |
R5368 |
T21226 |
T21224 |
acl |
forms,question |
R5369 |
T21227 |
T21228 |
det |
the,domain |
R5370 |
T21228 |
T21226 |
nsubj |
domain,forms |
R5371 |
T21280 |
T21281 |
det |
the,chromatin |
R5372 |
T21229 |
T21228 |
compound |
SAM,domain |
R5373 |
T21230 |
T21228 |
prep |
of,domain |
R5374 |
T21281 |
T21279 |
pobj |
chromatin,along |
R5375 |
T21231 |
T21232 |
compound |
mr,s |
R5376 |
T21232 |
T21230 |
pobj |
s,of |
R5377 |
T21233 |
T21232 |
punct |
-,s |
R5378 |
T21282 |
T21272 |
advcl |
similar,mediate |
R5379 |
T21234 |
T21235 |
det |
a,structure |
R5380 |
T21235 |
T21226 |
dobj |
structure,forms |
R5381 |
T21283 |
T21282 |
prep |
to,similar |
R5382 |
T21236 |
T21235 |
amod |
polymeric,structure |
R5383 |
T21237 |
T21218 |
prep |
in,address |
R5384 |
T21238 |
T21239 |
det |
the,study |
R5385 |
T21284 |
T21283 |
pobj |
ph,to |
R5386 |
T21239 |
T21237 |
pobj |
study,in |
R5387 |
T21240 |
T21239 |
amod |
present,study |
R5388 |
T21241 |
T21222 |
punct |
", ",suggests |
R5389 |
T21242 |
T21243 |
det |
the,analysis |
R5390 |
T21243 |
T21222 |
nsubj |
analysis,suggests |
R5391 |
T21244 |
T21243 |
amod |
phylogenetic,analysis |
R5392 |
T21285 |
T21284 |
cc |
and,ph |
R5393 |
T21245 |
T21243 |
prep |
of,analysis |
R5394 |
T21286 |
T21285 |
punct |
/,and |
R5395 |
T21246 |
T21247 |
compound |
SAM,domain |
R5396 |
T21247 |
T21245 |
pobj |
domain,of |
R5397 |
T21248 |
T21247 |
prep |
of,domain |
R5398 |
T21249 |
T21250 |
compound |
mr,s |
R5399 |
T21287 |
T21285 |
cc |
or,and |
R5400 |
T21250 |
T21248 |
pobj |
s,of |
R5401 |
T21251 |
T21250 |
punct |
-,s |
R5402 |
T21252 |
T21250 |
cc |
and,s |
R5403 |
T21288 |
T21284 |
conj |
TEL,ph |
R5404 |
T21253 |
T21254 |
amod |
other,molecules |
R5405 |
T21254 |
T21250 |
conj |
molecules,s |
R5406 |
T21289 |
T21222 |
punct |
.,suggests |
R5407 |
T21255 |
T21256 |
compound |
SAM,domain |
R5408 |
T21256 |
T21257 |
npadvmod |
domain,containing |
R5409 |
T21257 |
T21254 |
amod |
containing,molecules |
R5410 |
T21291 |
T21292 |
mark |
Although,demonstrated |
R5411 |
T21258 |
T21257 |
punct |
-,containing |
R5412 |
T21259 |
T21260 |
mark |
that,form |
R5413 |
T21260 |
T21222 |
ccomp |
form,suggests |
R5414 |
T21261 |
T21262 |
compound |
mr,s |
R5415 |
T21292 |
T21299 |
advcl |
demonstrated,fit |
R5416 |
T21262 |
T21260 |
nsubj |
s,form |
R5417 |
T21263 |
T21262 |
punct |
-,s |
R5418 |
T21293 |
T21294 |
poss |
our,results |
R5419 |
T21264 |
T21260 |
aux |
can,form |
R5420 |
T21265 |
T21266 |
nmod |
head,polymer |
R5421 |
T21266 |
T21260 |
dobj |
polymer,form |
R5422 |
T21294 |
T21292 |
nsubj |
results,demonstrated |
R5423 |
T21267 |
T21265 |
punct |
-,head |
R5424 |
T21268 |
T21265 |
prep |
to,head |
R5425 |
T21295 |
T21294 |
prep |
in,results |
R5426 |
T21269 |
T21268 |
punct |
-,to |
R5427 |
T21270 |
T21268 |
pobj |
tail,to |
R5428 |
T21271 |
T21260 |
cc |
and,form |
R5429 |
T21296 |
T21297 |
det |
the,assay |
R5430 |
T21272 |
T21260 |
conj |
mediate,form |
R5431 |
T21273 |
T21274 |
compound |
gene,silencing |
R5432 |
T21274 |
T21272 |
dobj |
silencing,mediate |
R5433 |
T21297 |
T21295 |
pobj |
assay,in |
R5434 |
T21275 |
T21272 |
prep |
by,mediate |
R5435 |
T21276 |
T21275 |
pcomp |
spreading,by |
R5436 |
T21298 |
T21297 |
compound |
immunoprecipitation,assay |
R5437 |
T21277 |
T21278 |
amod |
repressive,complexes |
R5438 |
T21278 |
T21276 |
dobj |
complexes,spreading |
R5439 |
T21300 |
T21301 |
mark |
that,interact |
R5440 |
T21301 |
T21292 |
ccomp |
interact,demonstrated |
R5441 |
T21385 |
T21384 |
punct |
-,specific |
R5442 |
T21302 |
T21303 |
det |
the,constructs |
R5443 |
T21386 |
T21387 |
npadvmod |
DNA,binding |
R5444 |
T21387 |
T21382 |
amod |
binding,domain |
R5445 |
T21303 |
T21301 |
nsubj |
constructs,interact |
R5446 |
T21388 |
T21389 |
punct |
", ",domain |
R5447 |
T21389 |
T21382 |
appos |
domain,domain |
R5448 |
T21304 |
T21305 |
npadvmod |
N,terminal |
R5449 |
T21390 |
T21389 |
advmod |
namely,domain |
R5450 |
T21391 |
T21389 |
det |
the,domain |
R5451 |
T21305 |
T21303 |
amod |
terminal,constructs |
R5452 |
T21392 |
T21389 |
compound |
ETS,domain |
R5453 |
T21393 |
T21379 |
punct |
", ",contains |
R5454 |
T21394 |
T21379 |
cc |
and,contains |
R5455 |
T21306 |
T21305 |
punct |
-,terminal |
R5456 |
T21395 |
T21379 |
conj |
binds,contains |
R5457 |
T21396 |
T21395 |
prep |
to,binds |
R5458 |
T21307 |
T21303 |
acl |
lacking,constructs |
R5459 |
T21397 |
T21398 |
amod |
specific,sites |
R5460 |
T21398 |
T21396 |
pobj |
sites,to |
R5461 |
T21399 |
T21395 |
prep |
via,binds |
R5462 |
T21308 |
T21309 |
det |
a,domain |
R5463 |
T21400 |
T21401 |
poss |
its,domain |
R5464 |
T21401 |
T21399 |
pobj |
domain,via |
R5465 |
T21402 |
T21401 |
compound |
ETS,domain |
R5466 |
T21309 |
T21307 |
dobj |
domain,lacking |
R5467 |
T21403 |
T21404 |
punct |
[,41 |
R5468 |
T21404 |
T21377 |
parataxis |
41,indicated |
R5469 |
T21310 |
T21309 |
compound |
SAM,domain |
R5470 |
T21405 |
T21404 |
punct |
],41 |
R5471 |
T21406 |
T21377 |
punct |
.,indicated |
R5472 |
T21311 |
T21301 |
advmod |
still,interact |
R5473 |
T21408 |
T21409 |
nsubj |
TEL,serve |
R5474 |
T21312 |
T21301 |
prep |
with,interact |
R5475 |
T21410 |
T21409 |
aux |
could,serve |
R5476 |
T21411 |
T21412 |
aux |
to,nucleate |
R5477 |
T21412 |
T21409 |
xcomp |
nucleate,serve |
R5478 |
T21313 |
T21314 |
det |
each,other |
R5479 |
T21413 |
T21414 |
det |
a,polymer |
R5480 |
T21414 |
T21412 |
dobj |
polymer,nucleate |
R5481 |
T21314 |
T21312 |
pobj |
other,with |
R5482 |
T21415 |
T21414 |
punct |
", ",polymer |
R5483 |
T21416 |
T21417 |
dep |
which,spread |
R5484 |
T21417 |
T21414 |
relcl |
spread,polymer |
R5485 |
T21315 |
T21299 |
punct |
", ",fit |
R5486 |
T21418 |
T21417 |
aux |
would,spread |
R5487 |
T21419 |
T21417 |
prep |
by,spread |
R5488 |
T21420 |
T21419 |
pobj |
oligomerization,by |
R5489 |
T21316 |
T21317 |
det |
these,results |
R5490 |
T21421 |
T21420 |
prep |
of,oligomerization |
R5491 |
T21317 |
T21299 |
nsubj |
results,fit |
R5492 |
T21422 |
T21423 |
det |
the,domain |
R5493 |
T21318 |
T21299 |
aux |
do,fit |
R5494 |
T21423 |
T21421 |
pobj |
domain,of |
R5495 |
T21424 |
T21423 |
compound |
SAM,domain |
R5496 |
T21319 |
T21299 |
neg |
not,fit |
R5497 |
T21425 |
T21409 |
punct |
.,serve |
R5498 |
T21320 |
T21299 |
prep |
into,fit |
R5499 |
T21427 |
T21428 |
prep |
In,contain |
R5500 |
T21429 |
T21427 |
pobj |
contrast,In |
R5501 |
T21321 |
T21322 |
det |
the,model |
R5502 |
T21430 |
T21429 |
prep |
to,contrast |
R5503 |
T21431 |
T21430 |
pobj |
TEL,to |
R5504 |
T21432 |
T21428 |
punct |
", ",contain |
R5505 |
T21322 |
T21320 |
pobj |
model,into |
R5506 |
T21433 |
T21428 |
nsubj |
ph,contain |
R5507 |
T21434 |
T21428 |
aux |
does,contain |
R5508 |
T21323 |
T21322 |
nmod |
head,model |
R5509 |
T21435 |
T21428 |
neg |
not,contain |
R5510 |
T21436 |
T21437 |
det |
an,motif |
R5511 |
T21437 |
T21428 |
dobj |
motif,contain |
R5512 |
T21324 |
T21323 |
punct |
-,head |
R5513 |
T21438 |
T21437 |
amod |
obvious,motif |
R5514 |
T21439 |
T21440 |
npadvmod |
sequence,specific |
R5515 |
T21440 |
T21437 |
amod |
specific,motif |
R5516 |
T21325 |
T21323 |
prep |
to,head |
R5517 |
T21441 |
T21440 |
punct |
-,specific |
R5518 |
T21442 |
T21443 |
npadvmod |
DNA,binding |
R5519 |
T21443 |
T21437 |
amod |
binding,motif |
R5520 |
T21326 |
T21325 |
punct |
-,to |
R5521 |
T21444 |
T21445 |
punct |
(,16 |
R5522 |
T21445 |
T21428 |
parataxis |
16,contain |
R5523 |
T21446 |
T21445 |
punct |
),16 |
R5524 |
T21327 |
T21325 |
pobj |
tail,to |
R5525 |
T21447 |
T21428 |
punct |
.,contain |
R5526 |
T21449 |
T21450 |
advmod |
Therefore,require |
R5527 |
T21328 |
T21322 |
compound |
polymer,model |
R5528 |
T21451 |
T21450 |
punct |
", ",require |
R5529 |
T21452 |
T21453 |
poss |
its,binding |
R5530 |
T21329 |
T21299 |
punct |
.,fit |
R5531 |
T21453 |
T21450 |
nsubj |
binding,require |
R5532 |
T21454 |
T21453 |
amod |
initial,binding |
R5533 |
T21331 |
T21332 |
nsubj |
We,exclude |
R5534 |
T21333 |
T21332 |
aux |
can,exclude |
R5535 |
T21455 |
T21453 |
prep |
to,binding |
R5536 |
T21334 |
T21332 |
neg |
not,exclude |
R5537 |
T21456 |
T21457 |
det |
the,template |
R5538 |
T21457 |
T21455 |
pobj |
template,to |
R5539 |
T21458 |
T21450 |
aux |
may,require |
R5540 |
T21335 |
T21336 |
det |
the,possibility |
R5541 |
T21459 |
T21460 |
compound |
protein,protein |
R5542 |
T21460 |
T21462 |
compound |
protein,interactions |
R5543 |
T21461 |
T21460 |
punct |
-,protein |
R5544 |
T21336 |
T21332 |
dobj |
possibility,exclude |
R5545 |
T21462 |
T21450 |
dobj |
interactions,require |
R5546 |
T21463 |
T21462 |
prep |
with,interactions |
R5547 |
T21464 |
T21465 |
amod |
other,repressors |
R5548 |
T21465 |
T21463 |
pobj |
repressors,with |
R5549 |
T21337 |
T21338 |
mark |
that,is |
R5550 |
T21466 |
T21467 |
npadvmod |
sequence,specific |
R5551 |
T21467 |
T21465 |
amod |
specific,repressors |
R5552 |
T21468 |
T21467 |
punct |
-,specific |
R5553 |
T21338 |
T21336 |
acl |
is,possibility |
R5554 |
T21469 |
T21465 |
amod |
transcriptional,repressors |
R5555 |
T21470 |
T21450 |
punct |
.,require |
R5556 |
T21339 |
T21340 |
det |
the,interaction |
R5557 |
T21472 |
T21473 |
det |
The,repressors |
R5558 |
T21473 |
T21479 |
nsubj |
repressors,have |
R5559 |
T21340 |
T21338 |
nsubj |
interaction,is |
R5560 |
T21474 |
T21473 |
nmod |
segmentation,repressors |
R5561 |
T21475 |
T21476 |
npadvmod |
gene,encoding |
R5562 |
T21476 |
T21473 |
amod |
encoding,repressors |
R5563 |
T21341 |
T21340 |
amod |
resulting,interaction |
R5564 |
T21477 |
T21476 |
punct |
-,encoding |
R5565 |
T21478 |
T21473 |
amod |
transcriptional,repressors |
R5566 |
T21342 |
T21343 |
compound |
protein,protein |
R5567 |
T21480 |
T21481 |
amod |
such,as |
R5568 |
T21481 |
T21473 |
prep |
as,repressors |
R5569 |
T21482 |
T21481 |
pobj |
Hunchback,as |
R5570 |
T21343 |
T21340 |
compound |
protein,interaction |
R5571 |
T21483 |
T21484 |
det |
a,role |
R5572 |
T21484 |
T21479 |
dobj |
role,have |
R5573 |
T21344 |
T21343 |
punct |
-,protein |
R5574 |
T21485 |
T21484 |
prep |
in,role |
R5575 |
T21486 |
T21485 |
pcomp |
recruiting,in |
R5576 |
T21487 |
T21488 |
nmod |
SAM,proteins |
R5577 |
T21345 |
T21340 |
prep |
of,interaction |
R5578 |
T21488 |
T21486 |
dobj |
proteins,recruiting |
R5579 |
T21489 |
T21490 |
npadvmod |
domain,containing |
R5580 |
T21346 |
T21347 |
compound |
mr,s |
R5581 |
T21347 |
T21345 |
pobj |
s,of |
R5582 |
T21348 |
T21347 |
punct |
-,s |
R5583 |
T21349 |
T21350 |
det |
an,artifact |
R5584 |
T21350 |
T21338 |
attr |
artifact,is |
R5585 |
T21490 |
T21488 |
amod |
containing,proteins |
R5586 |
T21491 |
T21490 |
punct |
-,containing |
R5587 |
T21492 |
T21488 |
compound |
PcG,proteins |
R5588 |
T21351 |
T21350 |
prep |
of,artifact |
R5589 |
T21493 |
T21488 |
punct |
", ",proteins |
R5590 |
T21494 |
T21495 |
dep |
which,spread |
R5591 |
T21495 |
T21488 |
relcl |
spread,proteins |
R5592 |
T21352 |
T21353 |
det |
the,conditions |
R5593 |
T21496 |
T21495 |
aux |
can,spread |
R5594 |
T21497 |
T21495 |
prep |
along,spread |
R5595 |
T21498 |
T21499 |
det |
the,template |
R5596 |
T21353 |
T21351 |
pobj |
conditions,of |
R5597 |
T21499 |
T21497 |
pobj |
template,along |
R5598 |
T21500 |
T21495 |
prep |
via,spread |
R5599 |
T21501 |
T21500 |
pobj |
polymerization,via |
R5600 |
T21502 |
T21503 |
punct |
[,42 |
R5601 |
T21503 |
T21479 |
parataxis |
42,have |
R5602 |
T21504 |
T21503 |
punct |
],42 |
R5603 |
T21354 |
T21353 |
compound |
overexpression,conditions |
R5604 |
T21505 |
T21479 |
punct |
.,have |
R5605 |
T21507 |
T21508 |
mark |
Since,contain |
R5606 |
T21355 |
T21332 |
punct |
.,exclude |
R5607 |
T21508 |
T21514 |
advcl |
contain,suppose |
R5608 |
T21509 |
T21510 |
compound |
mr,s |
R5609 |
T21357 |
T21358 |
det |
The,issue |
R5610 |
T21510 |
T21508 |
nsubj |
s,contain |
R5611 |
T21511 |
T21510 |
punct |
-,s |
R5612 |
T21512 |
T21508 |
aux |
does,contain |
R5613 |
T21513 |
T21508 |
neg |
not,contain |
R5614 |
T21358 |
T21359 |
nsubj |
issue,awaits |
R5615 |
T21515 |
T21516 |
amod |
obvious,motifs |
R5616 |
T21516 |
T21508 |
dobj |
motifs,contain |
R5617 |
T21360 |
T21358 |
prep |
of,issue |
R5618 |
T21517 |
T21518 |
npadvmod |
DNA,binding |
R5619 |
T21518 |
T21516 |
amod |
binding,motifs |
R5620 |
T21519 |
T21514 |
punct |
", ",suppose |
R5621 |
T21361 |
T21362 |
mark |
whether,forms |
R5622 |
T21520 |
T21514 |
nsubj |
we,suppose |
R5623 |
T21521 |
T21522 |
mark |
that,is |
R5624 |
T21522 |
T21514 |
ccomp |
is,suppose |
R5625 |
T21362 |
T21360 |
pcomp |
forms,of |
R5626 |
T21523 |
T21522 |
expl |
there,is |
R5627 |
T21524 |
T21525 |
det |
a,factor |
R5628 |
T21525 |
T21522 |
attr |
factor,is |
R5629 |
T21363 |
T21362 |
cc |
or,forms |
R5630 |
T21526 |
T21527 |
npadvmod |
sequence,specific |
R5631 |
T21527 |
T21525 |
amod |
specific,factor |
R5632 |
T21528 |
T21527 |
punct |
-,specific |
R5633 |
T21364 |
T21362 |
neg |
not,forms |
R5634 |
T21529 |
T21525 |
compound |
transcription,factor |
R5635 |
T21530 |
T21525 |
punct |
(,factor |
R5636 |
T21531 |
T21525 |
nmod |
s,factor |
R5637 |
T21365 |
T21366 |
compound |
mr,s |
R5638 |
T21532 |
T21525 |
punct |
),factor |
R5639 |
T21533 |
T21534 |
dep |
which,interacts |
R5640 |
T21534 |
T21525 |
relcl |
interacts,factor |
R5641 |
T21366 |
T21362 |
nsubj |
s,forms |
R5642 |
T21535 |
T21534 |
prep |
with,interacts |
R5643 |
T21536 |
T21537 |
compound |
mr,s |
R5644 |
T21537 |
T21535 |
pobj |
s,with |
R5645 |
T21367 |
T21366 |
punct |
-,s |
R5646 |
T21538 |
T21537 |
punct |
-,s |
R5647 |
T21539 |
T21514 |
punct |
.,suppose |
R5648 |
T21368 |
T21369 |
det |
a,polymer |
R5649 |
T21541 |
T21542 |
advmod |
However,find |
R5650 |
T21369 |
T21362 |
dobj |
polymer,forms |
R5651 |
T21543 |
T21542 |
punct |
", ",find |
R5652 |
T21544 |
T21542 |
nsubj |
we,find |
R5653 |
T21545 |
T21542 |
aux |
did,find |
R5654 |
T21370 |
T21371 |
amod |
future,analysis |
R5655 |
T21546 |
T21542 |
neg |
not,find |
R5656 |
T21547 |
T21548 |
det |
any,factors |
R5657 |
T21548 |
T21542 |
dobj |
factors,find |
R5658 |
T21371 |
T21359 |
dobj |
analysis,awaits |
R5659 |
T21549 |
T21548 |
compound |
transcription,factors |
R5660 |
T21550 |
T21542 |
prep |
in,find |
R5661 |
T21372 |
T21359 |
punct |
.,awaits |
R5662 |
T21551 |
T21552 |
det |
the,screening |
R5663 |
T21552 |
T21550 |
pobj |
screening,in |
R5664 |
T21374 |
T21375 |
det |
A,report |
R5665 |
T21553 |
T21552 |
amod |
present,screening |
R5666 |
T21554 |
T21552 |
nmod |
yeast,screening |
R5667 |
T21555 |
T21556 |
nummod |
two,hybrid |
R5668 |
T21556 |
T21552 |
compound |
hybrid,screening |
R5669 |
T21375 |
T21377 |
nsubj |
report,indicated |
R5670 |
T21557 |
T21556 |
punct |
-,hybrid |
R5671 |
T21558 |
T21542 |
punct |
.,find |
R5672 |
T21376 |
T21375 |
amod |
previous,report |
R5673 |
T21560 |
T21561 |
nsubj |
We,found |
R5674 |
T21562 |
T21561 |
advmod |
also,found |
R5675 |
T21378 |
T21379 |
mark |
that,contains |
R5676 |
T21563 |
T21564 |
mark |
that,functions |
R5677 |
T21564 |
T21561 |
ccomp |
functions,found |
R5678 |
T21565 |
T21566 |
amod |
full,length |
R5679 |
T21566 |
T21568 |
compound |
length,s |
R5680 |
T21379 |
T21377 |
ccomp |
contains,indicated |
R5681 |
T21567 |
T21566 |
punct |
-,length |
R5682 |
T21568 |
T21564 |
nsubj |
s,functions |
R5683 |
T21569 |
T21568 |
compound |
mr,s |
R5684 |
T21380 |
T21379 |
nsubj |
TEL,contains |
R5685 |
T21570 |
T21568 |
punct |
-,s |
R5686 |
T21571 |
T21568 |
acl |
fused,s |
R5687 |
T21572 |
T21571 |
prep |
to,fused |
R5688 |
T21381 |
T21382 |
det |
a,domain |
R5689 |
T21573 |
T21574 |
det |
the,domain |
R5690 |
T21574 |
T21572 |
pobj |
domain,to |
R5691 |
T21575 |
T21574 |
nmod |
GAL4,domain |
R5692 |
T21382 |
T21379 |
dobj |
domain,contains |
R5693 |
T21576 |
T21577 |
npadvmod |
DNA,binding |
R5694 |
T21577 |
T21574 |
amod |
binding,domain |
R5695 |
T21578 |
T21579 |
punct |
(,mrs |
R5696 |
T21383 |
T21384 |
npadvmod |
sequence,specific |
R5697 |
T21579 |
T21568 |
parataxis |
mrs,s |
R5698 |
T21580 |
T21579 |
compound |
DBD,mrs |
R5699 |
T21581 |
T21579 |
punct |
-,mrs |
R5700 |
T21384 |
T21382 |
amod |
specific,domain |
R5701 |
T21582 |
T21579 |
punct |
),mrs |
R5702 |
T21583 |
T21564 |
prep |
as,functions |
R5703 |
T21584 |
T21585 |
det |
a,repressor |
R5704 |
T21585 |
T21583 |
pobj |
repressor,as |
R5705 |
T21586 |
T21585 |
amod |
transcriptional,repressor |
R5706 |
T21587 |
T21561 |
punct |
.,found |
R5707 |
T21595 |
T21593 |
acl |
involved,idea |
R5708 |
T21589 |
T21590 |
nsubj |
This,support |
R5709 |
T21591 |
T21590 |
aux |
may,support |
R5710 |
T21592 |
T21593 |
det |
the,idea |
R5711 |
T21596 |
T21597 |
compound |
mr,s |
R5712 |
T21593 |
T21590 |
dobj |
idea,support |
R5713 |
T21594 |
T21595 |
mark |
that,involved |
R5714 |
T21597 |
T21595 |
nsubjpass |
s,involved |
R5715 |
T21598 |
T21597 |
punct |
-,s |
R5716 |
T21599 |
T21595 |
auxpass |
is,involved |
R5717 |
T21600 |
T21595 |
prep |
in,involved |
R5718 |
T21700 |
T21695 |
prep |
at,contains |
R5719 |
T21701 |
T21702 |
det |
the,terminus |
R5720 |
T21601 |
T21602 |
amod |
repressive,complexes |
R5721 |
T21702 |
T21700 |
pobj |
terminus,at |
R5722 |
T21703 |
T21702 |
compound |
C,terminus |
R5723 |
T21602 |
T21600 |
pobj |
complexes,in |
R5724 |
T21704 |
T21702 |
punct |
-,terminus |
R5725 |
T21705 |
T21670 |
punct |
", ",reported |
R5726 |
T21706 |
T21670 |
auxpass |
was,reported |
R5727 |
T21603 |
T21602 |
amod |
similar,complexes |
R5728 |
T21707 |
T21670 |
prep |
as,reported |
R5729 |
T21708 |
T21709 |
det |
a,repressor |
R5730 |
T21604 |
T21603 |
prep |
to,similar |
R5731 |
T21709 |
T21707 |
pobj |
repressor,as |
R5732 |
T21710 |
T21709 |
amod |
transcriptional,repressor |
R5733 |
T21711 |
T21670 |
cc |
and,reported |
R5734 |
T21605 |
T21606 |
amod |
other,proteins |
R5735 |
T21712 |
T21713 |
det |
the,activity |
R5736 |
T21606 |
T21604 |
pobj |
proteins,to |
R5737 |
T21713 |
T21715 |
nsubj |
activity,required |
R5738 |
T21607 |
T21608 |
compound |
SAM,domain |
R5739 |
T21714 |
T21713 |
compound |
repressor,activity |
R5740 |
T21715 |
T21670 |
conj |
required,reported |
R5741 |
T21608 |
T21609 |
npadvmod |
domain,containing |
R5742 |
T21716 |
T21713 |
prep |
of,activity |
R5743 |
T21717 |
T21718 |
nmod |
H,MBT |
R5744 |
T21609 |
T21606 |
amod |
containing,proteins |
R5745 |
T21718 |
T21716 |
pobj |
MBT,of |
R5746 |
T21719 |
T21720 |
punct |
-,L |
R5747 |
T21720 |
T21717 |
prep |
L,H |
R5748 |
T21610 |
T21609 |
punct |
-,containing |
R5749 |
T21721 |
T21722 |
punct |
(,3 |
R5750 |
T21722 |
T21717 |
parataxis |
3,H |
R5751 |
T21723 |
T21722 |
punct |
),3 |
R5752 |
T21611 |
T21590 |
punct |
.,support |
R5753 |
T21724 |
T21715 |
advmod |
mainly,required |
R5754 |
T21725 |
T21726 |
det |
the,presence |
R5755 |
T21726 |
T21715 |
dobj |
presence,required |
R5756 |
T21727 |
T21726 |
prep |
of,presence |
R5757 |
T21728 |
T21729 |
det |
the,repeats |
R5758 |
T21613 |
T21614 |
poss |
Our,results |
R5759 |
T21729 |
T21727 |
pobj |
repeats,of |
R5760 |
T21730 |
T21729 |
compound |
MBT,repeats |
R5761 |
T21731 |
T21729 |
cc |
but,repeats |
R5762 |
T21732 |
T21731 |
neg |
not,but |
R5763 |
T21733 |
T21734 |
det |
the,domain |
R5764 |
T21614 |
T21615 |
nsubj |
results,showed |
R5765 |
T21734 |
T21729 |
conj |
domain,repeats |
R5766 |
T21735 |
T21734 |
compound |
SAM,domain |
R5767 |
T21616 |
T21615 |
punct |
", ",showed |
R5768 |
T21736 |
T21737 |
punct |
[,45 |
R5769 |
T21737 |
T21715 |
parataxis |
45,required |
R5770 |
T21738 |
T21737 |
punct |
],45 |
R5771 |
T21739 |
T21670 |
punct |
.,reported |
R5772 |
T21617 |
T21615 |
advmod |
however,showed |
R5773 |
T21741 |
T21742 |
aux |
To,determine |
R5774 |
T21618 |
T21615 |
punct |
", ",showed |
R5775 |
T21742 |
T21743 |
advcl |
determine,performed |
R5776 |
T21744 |
T21745 |
det |
the,region |
R5777 |
T21619 |
T21620 |
mark |
that,is |
R5778 |
T21745 |
T21742 |
dobj |
region,determine |
R5779 |
T21746 |
T21745 |
amod |
transcriptional,region |
R5780 |
T21747 |
T21745 |
compound |
repressor,region |
R5781 |
T21620 |
T21615 |
ccomp |
is,showed |
R5782 |
T21748 |
T21745 |
prep |
of,region |
R5783 |
T21749 |
T21750 |
det |
the,protein |
R5784 |
T21750 |
T21748 |
pobj |
protein,of |
R5785 |
T21621 |
T21622 |
det |
the,association |
R5786 |
T21751 |
T21752 |
compound |
mr,s |
R5787 |
T21752 |
T21750 |
compound |
s,protein |
R5788 |
T21753 |
T21752 |
punct |
-,s |
R5789 |
T21622 |
T21620 |
nsubj |
association,is |
R5790 |
T21754 |
T21743 |
punct |
", ",performed |
R5791 |
T21755 |
T21743 |
nsubj |
we,performed |
R5792 |
T21756 |
T21757 |
det |
a,assay |
R5793 |
T21623 |
T21622 |
compound |
self,association |
R5794 |
T21757 |
T21743 |
dobj |
assay,performed |
R5795 |
T21758 |
T21757 |
compound |
luciferase,assay |
R5796 |
T21759 |
T21743 |
advcl |
using,performed |
R5797 |
T21624 |
T21622 |
punct |
-,association |
R5798 |
T21760 |
T21761 |
npadvmod |
site,directed |
R5799 |
T21761 |
T21763 |
amod |
directed,mutants |
R5800 |
T21762 |
T21761 |
punct |
-,directed |
R5801 |
T21625 |
T21622 |
prep |
of,association |
R5802 |
T21763 |
T21759 |
dobj |
mutants,using |
R5803 |
T21764 |
T21765 |
punct |
(,W404A |
R5804 |
T21765 |
T21743 |
parataxis |
W404A,performed |
R5805 |
T21626 |
T21627 |
compound |
mr,s |
R5806 |
T21766 |
T21765 |
compound |
DBD,W404A |
R5807 |
T21767 |
T21765 |
punct |
-,W404A |
R5808 |
T21768 |
T21765 |
cc |
and,W404A |
R5809 |
T21769 |
T21770 |
compound |
DBD,G453A |
R5810 |
T21770 |
T21765 |
conj |
G453A,W404A |
R5811 |
T21771 |
T21770 |
punct |
-,G453A |
R5812 |
T21772 |
T21765 |
punct |
),W404A |
R5813 |
T21627 |
T21625 |
pobj |
s,of |
R5814 |
T21773 |
T21743 |
punct |
.,performed |
R5815 |
T21775 |
T21776 |
det |
The,result |
R5816 |
T21628 |
T21627 |
punct |
-,s |
R5817 |
T21776 |
T21777 |
nsubj |
result,showed |
R5818 |
T21778 |
T21779 |
mark |
that,compromises |
R5819 |
T21629 |
T21622 |
prep |
through,association |
R5820 |
T21779 |
T21777 |
ccomp |
compromises,showed |
R5821 |
T21780 |
T21781 |
det |
the,ability |
R5822 |
T21781 |
T21779 |
nsubj |
ability,compromises |
R5823 |
T21630 |
T21631 |
poss |
its,domain |
R5824 |
T21782 |
T21781 |
amod |
reduced,ability |
R5825 |
T21783 |
T21781 |
compound |
binding,ability |
R5826 |
T21631 |
T21629 |
pobj |
domain,through |
R5827 |
T21784 |
T21781 |
prep |
of,ability |
R5828 |
T21785 |
T21786 |
compound |
self,association |
R5829 |
T21786 |
T21784 |
pobj |
association,of |
R5830 |
T21632 |
T21631 |
compound |
SAM,domain |
R5831 |
T21787 |
T21786 |
punct |
-,association |
R5832 |
T21788 |
T21779 |
advmod |
partially,compromises |
R5833 |
T21789 |
T21790 |
det |
the,activity |
R5834 |
T21633 |
T21620 |
neg |
not,is |
R5835 |
T21790 |
T21779 |
dobj |
activity,compromises |
R5836 |
T21791 |
T21790 |
amod |
transcriptional,activity |
R5837 |
T21634 |
T21620 |
acomp |
essential,is |
R5838 |
T21792 |
T21790 |
amod |
repressive,activity |
R5839 |
T21793 |
T21790 |
prep |
of,activity |
R5840 |
T21794 |
T21795 |
compound |
mr,s |
R5841 |
T21635 |
T21634 |
prep |
for,essential |
R5842 |
T21795 |
T21793 |
pobj |
s,of |
R5843 |
T21796 |
T21795 |
punct |
-,s |
R5844 |
T21797 |
T21798 |
punct |
(,7D |
R5845 |
T21636 |
T21637 |
det |
the,activity |
R5846 |
T21637 |
T21635 |
pobj |
activity,for |
R5847 |
T21798 |
T21779 |
parataxis |
7D,compromises |
R5848 |
T21638 |
T21637 |
amod |
transcriptional,activity |
R5849 |
T21799 |
T21798 |
compound |
Fig.,7D |
R5850 |
T21800 |
T21798 |
punct |
),7D |
R5851 |
T21801 |
T21777 |
punct |
.,showed |
R5852 |
T21639 |
T21637 |
amod |
repressive,activity |
R5853 |
T21640 |
T21615 |
punct |
.,showed |
R5854 |
T21803 |
T21804 |
advmod |
However,was |
R5855 |
T21642 |
T21643 |
nsubjpass |
Polymerization,reported |
R5856 |
T21644 |
T21642 |
prep |
of,Polymerization |
R5857 |
T21805 |
T21804 |
punct |
", ",was |
R5858 |
T21806 |
T21807 |
det |
the,effect |
R5859 |
T21807 |
T21804 |
nsubj |
effect,was |
R5860 |
T21808 |
T21807 |
amod |
repressive,effect |
R5861 |
T21809 |
T21810 |
advmod |
more,significant |
R5862 |
T21810 |
T21804 |
acomp |
significant,was |
R5863 |
T21645 |
T21646 |
det |
the,domain |
R5864 |
T21811 |
T21812 |
advmod |
when,co-introduced |
R5865 |
T21812 |
T21804 |
advcl |
co-introduced,was |
R5866 |
T21813 |
T21814 |
compound |
DBD,tail |
R5867 |
T21646 |
T21644 |
pobj |
domain,of |
R5868 |
T21647 |
T21646 |
compound |
SAM,domain |
R5869 |
T21648 |
T21643 |
aux |
has,reported |
R5870 |
T21814 |
T21812 |
nsubjpass |
tail,co-introduced |
R5871 |
T21649 |
T21643 |
auxpass |
been,reported |
R5872 |
T21815 |
T21814 |
punct |
-,tail |
R5873 |
T21816 |
T21814 |
punct |
", ",tail |
R5874 |
T21817 |
T21818 |
dep |
which,contain |
R5875 |
T21650 |
T21643 |
advmod |
previously,reported |
R5876 |
T21818 |
T21814 |
relcl |
contain,tail |
R5877 |
T21819 |
T21818 |
aux |
does,contain |
R5878 |
T21651 |
T21652 |
aux |
to,be |
R5879 |
T21820 |
T21818 |
neg |
not,contain |
R5880 |
T21821 |
T21822 |
compound |
SAM,domain |
R5881 |
T21822 |
T21818 |
dobj |
domain,contain |
R5882 |
T21652 |
T21643 |
xcomp |
be,reported |
R5883 |
T21823 |
T21812 |
punct |
", ",co-introduced |
R5884 |
T21824 |
T21812 |
auxpass |
was,co-introduced |
R5885 |
T21825 |
T21812 |
prep |
with,co-introduced |
R5886 |
T21653 |
T21652 |
acomp |
essential,be |
R5887 |
T21826 |
T21827 |
det |
the,plasmid |
R5888 |
T21827 |
T21825 |
pobj |
plasmid,with |
R5889 |
T21654 |
T21653 |
prep |
for,essential |
R5890 |
T21828 |
T21829 |
compound |
5xGAL4,pGL3 |
R5891 |
T21829 |
T21827 |
compound |
pGL3,plasmid |
R5892 |
T21830 |
T21829 |
punct |
-,pGL3 |
R5893 |
T21655 |
T21656 |
det |
the,functions |
R5894 |
T21831 |
T21827 |
compound |
reporter,plasmid |
R5895 |
T21832 |
T21804 |
punct |
.,was |
R5896 |
T21656 |
T21654 |
pobj |
functions,for |
R5897 |
T21834 |
T21835 |
advmod |
Therefore,conclude |
R5898 |
T21657 |
T21656 |
amod |
repressive,functions |
R5899 |
T21836 |
T21835 |
punct |
", ",conclude |
R5900 |
T21837 |
T21835 |
nsubj |
we,conclude |
R5901 |
T21838 |
T21839 |
mark |
that,is |
R5902 |
T21658 |
T21656 |
prep |
of,functions |
R5903 |
T21839 |
T21835 |
ccomp |
is,conclude |
R5904 |
T21840 |
T21841 |
det |
a,region |
R5905 |
T21659 |
T21658 |
pobj |
ph,of |
R5906 |
T21841 |
T21839 |
nsubj |
region,is |
R5907 |
T21842 |
T21841 |
prep |
from,region |
R5908 |
T21843 |
T21844 |
nmod |
amino,463 |
R5909 |
T21660 |
T21659 |
cc |
and,ph |
R5910 |
T21844 |
T21842 |
pobj |
463,from |
R5911 |
T21845 |
T21844 |
nmod |
acids,463 |
R5912 |
T21846 |
T21844 |
prep |
to,463 |
R5913 |
T21847 |
T21846 |
pobj |
542,to |
R5914 |
T21848 |
T21849 |
advmod |
mainly,responsible |
R5915 |
T21849 |
T21839 |
acomp |
responsible,is |
R5916 |
T21661 |
T21659 |
conj |
TEL,ph |
R5917 |
T21850 |
T21849 |
prep |
for,responsible |
R5918 |
T21851 |
T21852 |
det |
the,activity |
R5919 |
T21852 |
T21850 |
pobj |
activity,for |
R5920 |
T21662 |
T21663 |
punct |
[,44 |
R5921 |
T21853 |
T21852 |
compound |
repressor,activity |
R5922 |
T21854 |
T21839 |
prep |
in,is |
R5923 |
T21855 |
T21856 |
det |
the,case |
R5924 |
T21663 |
T21643 |
parataxis |
44,reported |
R5925 |
T21856 |
T21854 |
pobj |
case,in |
R5926 |
T21857 |
T21856 |
prep |
of,case |
R5927 |
T21664 |
T21663 |
nummod |
43,44 |
R5928 |
T21858 |
T21859 |
compound |
mr,s |
R5929 |
T21859 |
T21857 |
pobj |
s,of |
R5930 |
T21860 |
T21859 |
punct |
-,s |
R5931 |
T21665 |
T21663 |
punct |
",",44 |
R5932 |
T21861 |
T21835 |
punct |
.,conclude |
R5933 |
T21666 |
T21663 |
punct |
],44 |
R5934 |
T21863 |
T21864 |
amod |
Evolutionary,conservation |
R5935 |
T21864 |
T21865 |
nsubj |
conservation,underlie |
R5936 |
T21667 |
T21643 |
punct |
.,reported |
R5937 |
T21866 |
T21864 |
prep |
of,conservation |
R5938 |
T21867 |
T21868 |
det |
the,region |
R5939 |
T21868 |
T21866 |
pobj |
region,of |
R5940 |
T21669 |
T21670 |
prep |
On,reported |
R5941 |
T21869 |
T21870 |
npadvmod |
C,terminal |
R5942 |
T21870 |
T21868 |
amod |
terminal,region |
R5943 |
T21871 |
T21870 |
punct |
-,terminal |
R5944 |
T21671 |
T21672 |
det |
the,hand |
R5945 |
T21872 |
T21873 |
nummod |
80,aa |
R5946 |
T21873 |
T21868 |
compound |
aa,region |
R5947 |
T21874 |
T21868 |
prep |
of,region |
R5948 |
T21875 |
T21876 |
compound |
mr,s |
R5949 |
T21672 |
T21669 |
pobj |
hand,On |
R5950 |
T21876 |
T21874 |
pobj |
s,of |
R5951 |
T21877 |
T21876 |
punct |
-,s |
R5952 |
T21673 |
T21672 |
amod |
other,hand |
R5953 |
T21878 |
T21864 |
prep |
from,conservation |
R5954 |
T21879 |
T21878 |
pobj |
zebrafish,from |
R5955 |
T21880 |
T21878 |
prep |
through,from |
R5956 |
T21674 |
T21670 |
punct |
", ",reported |
R5957 |
T21881 |
T21880 |
pobj |
human,through |
R5958 |
T21882 |
T21865 |
aux |
may,underlie |
R5959 |
T21883 |
T21884 |
det |
the,importance |
R5960 |
T21675 |
T21676 |
amod |
human,protein |
R5961 |
T21884 |
T21865 |
dobj |
importance,underlie |
R5962 |
T21885 |
T21884 |
amod |
functional,importance |
R5963 |
T21676 |
T21670 |
nsubjpass |
protein,reported |
R5964 |
T21886 |
T21884 |
prep |
of,importance |
R5965 |
T21887 |
T21888 |
det |
this,region |
R5966 |
T21888 |
T21886 |
pobj |
region,of |
R5967 |
T21677 |
T21676 |
amod |
lethal,protein |
R5968 |
T21889 |
T21865 |
punct |
.,underlie |
R5969 |
T21891 |
T21892 |
nummod |
Two,complexes |
R5970 |
T21678 |
T21679 |
punct |
(,3 |
R5971 |
T21892 |
T21896 |
nsubjpass |
complexes,identified |
R5972 |
T21893 |
T21892 |
amod |
distinct,complexes |
R5973 |
T21679 |
T21677 |
parataxis |
3,lethal |
R5974 |
T21894 |
T21892 |
compound |
multiprotein,complexes |
R5975 |
T21895 |
T21892 |
compound |
PcG,complexes |
R5976 |
T21680 |
T21679 |
punct |
),3 |
R5977 |
T21897 |
T21892 |
punct |
", ",complexes |
R5978 |
T21898 |
T21892 |
appos |
PRC1,complexes |
R5979 |
T21681 |
T21682 |
amod |
malignant,tumor |
R5980 |
T21899 |
T21898 |
cc |
and,PRC1 |
R5981 |
T21900 |
T21898 |
conj |
PRC2,PRC1 |
R5982 |
T21901 |
T21896 |
punct |
", ",identified |
R5983 |
T21682 |
T21676 |
nmod |
tumor,protein |
R5984 |
T21902 |
T21896 |
aux |
have,identified |
R5985 |
T21903 |
T21896 |
auxpass |
been,identified |
R5986 |
T21683 |
T21682 |
nmod |
brain,tumor |
R5987 |
T21904 |
T21896 |
punct |
.,identified |
R5988 |
T21906 |
T21907 |
nsubjpass |
PRC2,involved |
R5989 |
T21684 |
T21685 |
punct |
(,3 |
R5990 |
T21908 |
T21907 |
auxpass |
is,involved |
R5991 |
T21909 |
T21907 |
prep |
in,involved |
R5992 |
T21685 |
T21682 |
parataxis |
3,tumor |
R5993 |
T21910 |
T21911 |
det |
the,initiation |
R5994 |
T21686 |
T21685 |
dep |
H,3 |
R5995 |
T21687 |
T21688 |
punct |
-,L |
R5996 |
T21688 |
T21686 |
prep |
L,H |
R5997 |
T21911 |
T21909 |
pobj |
initiation,in |
R5998 |
T21912 |
T21911 |
prep |
of,initiation |
R5999 |
T21913 |
T21912 |
pobj |
silencing,of |
R6000 |
T21689 |
T21685 |
punct |
(,3 |
R6001 |
T21914 |
T21907 |
cc |
and,involved |
R6002 |
T21915 |
T21907 |
conj |
contains,involved |
R6003 |
T21690 |
T21685 |
punct |
),3 |
R6004 |
T21916 |
T21917 |
compound |
histone,deacetylases |
R6005 |
T21917 |
T21915 |
dobj |
deacetylases,contains |
R6006 |
T21918 |
T21917 |
punct |
(,deacetylases |
R6007 |
T21691 |
T21682 |
appos |
MBT,tumor |
R6008 |
T21919 |
T21917 |
appos |
HDACs,deacetylases |
R6009 |
T21692 |
T21676 |
punct |
),protein |
R6010 |
T21920 |
T21917 |
punct |
),deacetylases |
R6011 |
T21921 |
T21917 |
cc |
and,deacetylases |
R6012 |
T21922 |
T21923 |
compound |
histone,methyltransferases |
R6013 |
T21923 |
T21917 |
conj |
methyltransferases,deacetylases |
R6014 |
T21693 |
T21676 |
punct |
", ",protein |
R6015 |
T21924 |
T21917 |
punct |
", ",deacetylases |
R6016 |
T21925 |
T21926 |
dep |
which,methylate |
R6017 |
T21926 |
T21917 |
relcl |
methylate,deacetylases |
R6018 |
T21927 |
T21926 |
aux |
can,methylate |
R6019 |
T21928 |
T21929 |
nmod |
histone,9 |
R6020 |
T21929 |
T21926 |
dobj |
9,methylate |
R6021 |
T21694 |
T21695 |
dep |
which,contains |
R6022 |
T21930 |
T21929 |
nmod |
H3,9 |
R6023 |
T21931 |
T21929 |
nmod |
lysine,9 |
R6024 |
T21932 |
T21929 |
cc |
and,9 |
R6025 |
T21695 |
T21676 |
relcl |
contains,protein |
R6026 |
T21933 |
T21929 |
conj |
27,9 |
R6027 |
T21934 |
T21929 |
punct |
", ",9 |
R6028 |
T21935 |
T21929 |
appos |
marks,9 |
R6029 |
T21696 |
T21695 |
advmod |
also,contains |
R6030 |
T21936 |
T21935 |
prep |
of,marks |
R6031 |
T21937 |
T21938 |
amod |
silenced,chromatin |
R6032 |
T21938 |
T21936 |
pobj |
chromatin,of |
R6033 |
T21697 |
T21698 |
det |
a,domain |
R6034 |
T21939 |
T21907 |
punct |
.,involved |
R6035 |
T21941 |
T21942 |
nsubj |
PRC1,recognizes |
R6036 |
T21698 |
T21695 |
dobj |
domain,contains |
R6037 |
T21943 |
T21941 |
punct |
", ",PRC1 |
R6038 |
T21699 |
T21698 |
compound |
SAM,domain |
R6039 |
T21944 |
T21941 |
prep |
including,PRC1 |
R6040 |
T21945 |
T21944 |
pobj |
ph,including |
R6041 |
T21946 |
T21942 |
punct |
", ",recognizes |
R6042 |
T22017 |
T22018 |
poss |
Our,assay |
R6043 |
T21947 |
T21948 |
det |
the,mark |
R6044 |
T21948 |
T21942 |
dobj |
mark,recognizes |
R6045 |
T21949 |
T21948 |
nmod |
histone,mark |
R6046 |
T21950 |
T21948 |
nmod |
H3,mark |
R6047 |
T22018 |
T22020 |
nsubj |
assay,showed |
R6048 |
T21951 |
T21948 |
nmod |
lysine,mark |
R6049 |
T21952 |
T21951 |
nummod |
27,lysine |
R6050 |
T21953 |
T21948 |
acl |
set,mark |
R6051 |
T22019 |
T22018 |
compound |
luciferase,assay |
R6052 |
T21954 |
T21953 |
agent |
by,set |
R6053 |
T21955 |
T21954 |
pobj |
PRC2,by |
R6054 |
T22021 |
T22020 |
advmod |
also,showed |
R6055 |
T21956 |
T21942 |
cc |
and,recognizes |
R6056 |
T21957 |
T21942 |
conj |
maintains,recognizes |
R6057 |
T21958 |
T21959 |
det |
a,state |
R6058 |
T21959 |
T21957 |
dobj |
state,maintains |
R6059 |
T22022 |
T22023 |
mark |
that,affected |
R6060 |
T21960 |
T21959 |
amod |
stable,state |
R6061 |
T22023 |
T22020 |
ccomp |
affected,showed |
R6062 |
T21961 |
T21959 |
prep |
of,state |
R6063 |
T21962 |
T21963 |
compound |
gene,repression |
R6064 |
T21963 |
T21961 |
pobj |
repression,of |
R6065 |
T21964 |
T21965 |
prep |
in,blocks |
R6066 |
T22024 |
T22025 |
amod |
transcriptional,repression |
R6067 |
T21965 |
T21959 |
relcl |
blocks,state |
R6068 |
T21966 |
T21964 |
pobj |
which,in |
R6069 |
T21967 |
T21965 |
nsubj |
PRC1,blocks |
R6070 |
T21968 |
T21969 |
compound |
chromatin,remodeling |
R6071 |
T21969 |
T21965 |
dobj |
remodeling,blocks |
R6072 |
T21970 |
T21969 |
prep |
by,remodeling |
R6073 |
T22025 |
T22023 |
nsubjpass |
repression,affected |
R6074 |
T21971 |
T21972 |
det |
the,complex |
R6075 |
T22026 |
T22025 |
prep |
of,repression |
R6076 |
T21972 |
T21970 |
pobj |
complex,by |
R6077 |
T22027 |
T22028 |
compound |
DBD,mrs |
R6078 |
T21973 |
T21972 |
nmod |
trithorax,complex |
R6079 |
T21974 |
T21975 |
npadvmod |
group,related |
R6080 |
T22028 |
T22026 |
pobj |
mrs,of |
R6081 |
T21975 |
T21972 |
amod |
related,complex |
R6082 |
T21976 |
T21975 |
punct |
-,related |
R6083 |
T21977 |
T21978 |
compound |
SWI,SNF |
R6084 |
T22029 |
T22028 |
punct |
-,mrs |
R6085 |
T21978 |
T21972 |
compound |
SNF,complex |
R6086 |
T21979 |
T21978 |
punct |
-,SNF |
R6087 |
T22030 |
T22023 |
auxpass |
was,affected |
R6088 |
T21980 |
T21981 |
punct |
[,47 |
R6089 |
T21981 |
T21965 |
parataxis |
47,blocks |
R6090 |
T22031 |
T22023 |
neg |
not,affected |
R6091 |
T21982 |
T21981 |
nummod |
46,47 |
R6092 |
T21983 |
T21981 |
punct |
",",47 |
R6093 |
T21984 |
T21981 |
punct |
],47 |
R6094 |
T22032 |
T22023 |
agent |
by,affected |
R6095 |
T21985 |
T21942 |
punct |
.,recognizes |
R6096 |
T22033 |
T22034 |
det |
the,addition |
R6097 |
T21987 |
T21988 |
advmod |
Therefore,thought |
R6098 |
T21989 |
T21988 |
punct |
", ",thought |
R6099 |
T22034 |
T22032 |
pobj |
addition,by |
R6100 |
T21990 |
T21991 |
det |
the,mechanism |
R6101 |
T21991 |
T21988 |
nsubjpass |
mechanism,thought |
R6102 |
T21992 |
T21991 |
prep |
of,mechanism |
R6103 |
T22035 |
T22034 |
prep |
of,addition |
R6104 |
T21993 |
T21992 |
pobj |
repression,of |
R6105 |
T21994 |
T21993 |
prep |
by,repression |
R6106 |
T21995 |
T21994 |
pobj |
PRC2,by |
R6107 |
T22036 |
T22037 |
amod |
various,concentrations |
R6108 |
T21996 |
T21988 |
auxpass |
is,thought |
R6109 |
T21997 |
T21998 |
aux |
to,be |
R6110 |
T22037 |
T22035 |
pobj |
concentrations,of |
R6111 |
T21998 |
T21988 |
xcomp |
be,thought |
R6112 |
T21999 |
T22000 |
npadvmod |
HDAC,dependent |
R6113 |
T22000 |
T21998 |
acomp |
dependent,be |
R6114 |
T22038 |
T22037 |
prep |
of,concentrations |
R6115 |
T22001 |
T22000 |
punct |
-,dependent |
R6116 |
T22039 |
T22040 |
compound |
trichostatin,A |
R6117 |
T22002 |
T22003 |
mark |
while,appears |
R6118 |
T22003 |
T21988 |
advcl |
appears,thought |
R6119 |
T22004 |
T22005 |
det |
the,mechanism |
R6120 |
T22005 |
T22003 |
nsubj |
mechanism,appears |
R6121 |
T22006 |
T22005 |
prep |
of,mechanism |
R6122 |
T22007 |
T22006 |
pobj |
repression,of |
R6123 |
T22008 |
T22007 |
prep |
by,repression |
R6124 |
T22040 |
T22038 |
pobj |
A,of |
R6125 |
T22009 |
T22008 |
pobj |
PRC1,by |
R6126 |
T22010 |
T22011 |
aux |
to,be |
R6127 |
T22011 |
T22003 |
xcomp |
be,appears |
R6128 |
T22041 |
T22040 |
punct |
", ",A |
R6129 |
T22012 |
T22013 |
npadvmod |
HDAC,independent |
R6130 |
T22013 |
T22011 |
acomp |
independent,be |
R6131 |
T22014 |
T22013 |
punct |
-,independent |
R6132 |
T22042 |
T22043 |
det |
a,inhibitor |
R6133 |
T22015 |
T21988 |
punct |
.,thought |
R6134 |
T22043 |
T22040 |
appos |
inhibitor,A |
R6135 |
T22044 |
T22043 |
amod |
potent,inhibitor |
R6136 |
T22045 |
T22043 |
compound |
HDAC,inhibitor |
R6137 |
T22046 |
T22047 |
punct |
(,shown |
R6138 |
T22124 |
T22123 |
advmod |
also,revealed |
R6139 |
T22125 |
T22126 |
mark |
that,is |
R6140 |
T22047 |
T22020 |
parataxis |
shown,showed |
R6141 |
T22126 |
T22123 |
ccomp |
is,revealed |
R6142 |
T22127 |
T22128 |
det |
the,activity |
R6143 |
T22128 |
T22126 |
nsubj |
activity,is |
R6144 |
T22048 |
T22047 |
nsubj |
data,shown |
R6145 |
T22129 |
T22128 |
amod |
repressive,activity |
R6146 |
T22130 |
T22128 |
prep |
of,activity |
R6147 |
T22049 |
T22047 |
neg |
not,shown |
R6148 |
T22131 |
T22132 |
compound |
mr,s |
R6149 |
T22132 |
T22130 |
pobj |
s,of |
R6150 |
T22133 |
T22132 |
punct |
-,s |
R6151 |
T22050 |
T22047 |
punct |
),shown |
R6152 |
T22134 |
T22135 |
advmod |
mainly,due |
R6153 |
T22135 |
T22126 |
prep |
due,is |
R6154 |
T22136 |
T22135 |
pcomp |
to,due |
R6155 |
T22051 |
T22020 |
punct |
.,showed |
R6156 |
T22137 |
T22138 |
det |
the,region |
R6157 |
T22138 |
T22135 |
pobj |
region,due |
R6158 |
T22139 |
T22140 |
npadvmod |
C,terminal |
R6159 |
T22053 |
T22054 |
advmod |
Therefore,speculate |
R6160 |
T22140 |
T22138 |
amod |
terminal,region |
R6161 |
T22141 |
T22140 |
punct |
-,terminal |
R6162 |
T22142 |
T22143 |
punct |
(,463 |
R6163 |
T22055 |
T22054 |
punct |
", ",speculate |
R6164 |
T22143 |
T22138 |
parataxis |
463,region |
R6165 |
T22056 |
T22054 |
nsubj |
we,speculate |
R6166 |
T22144 |
T22143 |
nmod |
amino,463 |
R6167 |
T22145 |
T22143 |
nmod |
acids,463 |
R6168 |
T22057 |
T22058 |
mark |
that,be |
R6169 |
T22146 |
T22143 |
prep |
to,463 |
R6170 |
T22147 |
T22146 |
pobj |
542,to |
R6171 |
T22148 |
T22143 |
punct |
),463 |
R6172 |
T22149 |
T22123 |
punct |
.,revealed |
R6173 |
T22151 |
T22152 |
advmod |
However,remain |
R6174 |
T22058 |
T22054 |
ccomp |
be,speculate |
R6175 |
T22153 |
T22152 |
punct |
", ",remain |
R6176 |
T22154 |
T22155 |
amod |
downstream,targets |
R6177 |
T22059 |
T22060 |
det |
the,mechanism |
R6178 |
T22155 |
T22152 |
nsubj |
targets,remain |
R6179 |
T22156 |
T22155 |
prep |
of,targets |
R6180 |
T22060 |
T22058 |
nsubj |
mechanism,be |
R6181 |
T22157 |
T22158 |
compound |
mr,s |
R6182 |
T22158 |
T22156 |
pobj |
s,of |
R6183 |
T22061 |
T22060 |
prep |
of,mechanism |
R6184 |
T22159 |
T22158 |
punct |
-,s |
R6185 |
T22160 |
T22152 |
advmod |
still,remain |
R6186 |
T22161 |
T22152 |
acomp |
unclear,remain |
R6187 |
T22062 |
T22061 |
pobj |
repression,of |
R6188 |
T22162 |
T22152 |
punct |
.,remain |
R6189 |
T22164 |
T22165 |
advmod |
In,situ |
R6190 |
T22063 |
T22062 |
prep |
of,repression |
R6191 |
T22165 |
T22166 |
amod |
situ,hybridization |
R6192 |
T22166 |
T22167 |
nsubj |
hybridization,showed |
R6193 |
T22064 |
T22065 |
compound |
mr,s |
R6194 |
T22168 |
T22169 |
mark |
that,is |
R6195 |
T22169 |
T22167 |
ccomp |
is,showed |
R6196 |
T22065 |
T22063 |
pobj |
s,of |
R6197 |
T22170 |
T22171 |
det |
the,peak |
R6198 |
T22171 |
T22169 |
nsubj |
peak,is |
R6199 |
T22172 |
T22171 |
prep |
of,peak |
R6200 |
T22066 |
T22065 |
punct |
-,s |
R6201 |
T22173 |
T22174 |
compound |
mr,s |
R6202 |
T22174 |
T22176 |
compound |
s,expression |
R6203 |
T22175 |
T22174 |
punct |
-,s |
R6204 |
T22067 |
T22058 |
aux |
may,be |
R6205 |
T22176 |
T22172 |
pobj |
expression,of |
R6206 |
T22177 |
T22178 |
advmod |
around,P6 |
R6207 |
T22178 |
T22169 |
attr |
P6,is |
R6208 |
T22068 |
T22069 |
npadvmod |
HDAC,independent |
R6209 |
T22179 |
T22178 |
punct |
", ",P6 |
R6210 |
T22180 |
T22181 |
advmod |
when,undergo |
R6211 |
T22069 |
T22058 |
acomp |
independent,be |
R6212 |
T22181 |
T22178 |
relcl |
undergo,P6 |
R6213 |
T22182 |
T22183 |
amod |
retinal,photoreceptors |
R6214 |
T22183 |
T22181 |
nsubj |
photoreceptors,undergo |
R6215 |
T22070 |
T22069 |
punct |
-,independent |
R6216 |
T22184 |
T22185 |
amod |
terminal,differentiation |
R6217 |
T22185 |
T22181 |
dobj |
differentiation,undergo |
R6218 |
T22186 |
T22167 |
punct |
.,showed |
R6219 |
T22071 |
T22069 |
cc |
and,independent |
R6220 |
T22188 |
T22189 |
nsubj |
We,hypothesize |
R6221 |
T22072 |
T22073 |
advmod |
more,similar |
R6222 |
T22190 |
T22191 |
mark |
that,be |
R6223 |
T22191 |
T22189 |
ccomp |
be,hypothesize |
R6224 |
T22192 |
T22193 |
det |
the,genes |
R6225 |
T22193 |
T22191 |
nsubj |
genes,be |
R6226 |
T22194 |
T22193 |
compound |
target,genes |
R6227 |
T22195 |
T22193 |
prep |
of,genes |
R6228 |
T22073 |
T22069 |
conj |
similar,independent |
R6229 |
T22196 |
T22197 |
compound |
mr,s |
R6230 |
T22197 |
T22195 |
pobj |
s,of |
R6231 |
T22198 |
T22197 |
punct |
-,s |
R6232 |
T22074 |
T22073 |
prep |
to,similar |
R6233 |
T22199 |
T22191 |
aux |
might,be |
R6234 |
T22200 |
T22201 |
amod |
non-photoreceptor,genes |
R6235 |
T22201 |
T22191 |
attr |
genes,be |
R6236 |
T22075 |
T22074 |
pobj |
that,to |
R6237 |
T22202 |
T22189 |
punct |
.,hypothesize |
R6238 |
T22076 |
T22075 |
prep |
of,that |
R6239 |
T22204 |
T22205 |
prep |
In,suppress |
R6240 |
T22206 |
T22207 |
det |
this,case |
R6241 |
T22077 |
T22078 |
compound |
PRC1,complex |
R6242 |
T22207 |
T22204 |
pobj |
case,In |
R6243 |
T22078 |
T22076 |
pobj |
complex,of |
R6244 |
T22079 |
T22054 |
punct |
.,speculate |
R6245 |
T22081 |
T22082 |
prep |
In,demonstrate |
R6246 |
T22208 |
T22205 |
punct |
", ",suppress |
R6247 |
T22209 |
T22210 |
compound |
mr,s |
R6248 |
T22083 |
T22084 |
det |
the,study |
R6249 |
T22210 |
T22205 |
nsubj |
s,suppress |
R6250 |
T22211 |
T22210 |
punct |
-,s |
R6251 |
T22212 |
T22205 |
aux |
may,suppress |
R6252 |
T22213 |
T22214 |
det |
the,expression |
R6253 |
T22084 |
T22081 |
pobj |
study,In |
R6254 |
T22214 |
T22205 |
dobj |
expression,suppress |
R6255 |
T22215 |
T22214 |
prep |
of,expression |
R6256 |
T22085 |
T22084 |
amod |
present,study |
R6257 |
T22216 |
T22217 |
amod |
non-photoreceptor,genes |
R6258 |
T22217 |
T22215 |
pobj |
genes,of |
R6259 |
T22218 |
T22205 |
prep |
in,suppress |
R6260 |
T22086 |
T22082 |
punct |
", ",demonstrate |
R6261 |
T22219 |
T22220 |
nmod |
rod,photoreceptors |
R6262 |
T22220 |
T22218 |
pobj |
photoreceptors,in |
R6263 |
T22221 |
T22219 |
cc |
and,rod |
R6264 |
T22087 |
T22088 |
det |
the,experiments |
R6265 |
T22222 |
T22219 |
conj |
cone,rod |
R6266 |
T22223 |
T22205 |
punct |
.,suppress |
R6267 |
T22088 |
T22082 |
nsubj |
experiments,demonstrate |
R6268 |
T22225 |
T22226 |
expl |
There,be |
R6269 |
T22227 |
T22226 |
aux |
may,be |
R6270 |
T22089 |
T22088 |
amod |
biochemical,experiments |
R6271 |
T22228 |
T22229 |
det |
another,possibility |
R6272 |
T22090 |
T22091 |
mark |
that,functions |
R6273 |
T22091 |
T22082 |
ccomp |
functions,demonstrate |
R6274 |
T22092 |
T22093 |
det |
the,protein |
R6275 |
T22229 |
T22226 |
attr |
possibility,be |
R6276 |
T22230 |
T22231 |
mark |
that,involved |
R6277 |
T22231 |
T22229 |
acl |
involved,possibility |
R6278 |
T22232 |
T22233 |
compound |
mr,s |
R6279 |
T22233 |
T22231 |
nsubjpass |
s,involved |
R6280 |
T22093 |
T22091 |
nsubj |
protein,functions |
R6281 |
T22234 |
T22233 |
punct |
-,s |
R6282 |
T22235 |
T22231 |
auxpass |
is,involved |
R6283 |
T22094 |
T22095 |
compound |
mr,s |
R6284 |
T22095 |
T22093 |
compound |
s,protein |
R6285 |
T22236 |
T22231 |
prep |
in,involved |
R6286 |
T22237 |
T22238 |
compound |
cell,fate |
R6287 |
T22238 |
T22239 |
compound |
fate,determination |
R6288 |
T22096 |
T22095 |
punct |
-,s |
R6289 |
T22239 |
T22236 |
pobj |
determination,in |
R6290 |
T22240 |
T22239 |
prep |
of,determination |
R6291 |
T22097 |
T22091 |
prep |
as,functions |
R6292 |
T22241 |
T22242 |
compound |
rod,photoreceptors |
R6293 |
T22242 |
T22240 |
pobj |
photoreceptors,of |
R6294 |
T22243 |
T22242 |
cc |
versus,photoreceptors |
R6295 |
T22098 |
T22099 |
det |
a,repressor |
R6296 |
T22244 |
T22245 |
compound |
cone,photoreceptors |
R6297 |
T22245 |
T22242 |
conj |
photoreceptors,photoreceptors |
R6298 |
T22099 |
T22097 |
pobj |
repressor,as |
R6299 |
T22246 |
T22226 |
punct |
.,be |
R6300 |
T22248 |
T22249 |
mark |
While,born |
R6301 |
T22100 |
T22099 |
amod |
transcriptional,repressor |
R6302 |
T22249 |
T22253 |
advcl |
born,born |
R6303 |
T22250 |
T22251 |
compound |
cone,photoreceptors |
R6304 |
T22101 |
T22091 |
cc |
and,functions |
R6305 |
T22251 |
T22249 |
nsubjpass |
photoreceptors,born |
R6306 |
T22252 |
T22249 |
auxpass |
are,born |
R6307 |
T22102 |
T22103 |
advmod |
possibly,regulates |
R6308 |
T22254 |
T22249 |
prep |
during,born |
R6309 |
T22255 |
T22256 |
det |
the,stages |
R6310 |
T22256 |
T22254 |
pobj |
stages,during |
R6311 |
T22103 |
T22091 |
conj |
regulates,functions |
R6312 |
T22257 |
T22258 |
amod |
early,embryonic |
R6313 |
T22258 |
T22256 |
amod |
embryonic,stages |
R6314 |
T22104 |
T22103 |
advmod |
down,regulates |
R6315 |
T22259 |
T22256 |
prep |
of,stages |
R6316 |
T22260 |
T22261 |
compound |
mouse,retinogenesis |
R6317 |
T22261 |
T22259 |
pobj |
retinogenesis,of |
R6318 |
T22105 |
T22103 |
punct |
-,regulates |
R6319 |
T22262 |
T22253 |
punct |
", ",born |
R6320 |
T22263 |
T22264 |
compound |
rod,photoreceptors |
R6321 |
T22106 |
T22107 |
det |
the,expression |
R6322 |
T22264 |
T22253 |
nsubjpass |
photoreceptors,born |
R6323 |
T22265 |
T22253 |
auxpass |
are,born |
R6324 |
T22266 |
T22253 |
advmod |
primarily,born |
R6325 |
T22107 |
T22103 |
dobj |
expression,regulates |
R6326 |
T22267 |
T22253 |
prep |
in,born |
R6327 |
T22268 |
T22269 |
det |
the,period |
R6328 |
T22269 |
T22267 |
pobj |
period,in |
R6329 |
T22270 |
T22271 |
amod |
late,embryonic |
R6330 |
T22271 |
T22269 |
amod |
embryonic,period |
R6331 |
T22108 |
T22107 |
amod |
spatial,expression |
R6332 |
T22272 |
T22271 |
cc |
and,embryonic |
R6333 |
T22273 |
T22274 |
amod |
early,postnatal |
R6334 |
T22274 |
T22271 |
conj |
postnatal,embryonic |
R6335 |
T22275 |
T22276 |
punct |
[,48 |
R6336 |
T22109 |
T22108 |
cc |
and,spatial |
R6337 |
T22276 |
T22253 |
parataxis |
48,born |
R6338 |
T22277 |
T22276 |
punct |
],48 |
R6339 |
T22110 |
T22108 |
conj |
temporal,spatial |
R6340 |
T22278 |
T22253 |
punct |
.,born |
R6341 |
T22280 |
T22281 |
det |
The,pattern |
R6342 |
T22111 |
T22107 |
prep |
of,expression |
R6343 |
T22281 |
T22283 |
nsubj |
pattern,suggest |
R6344 |
T22282 |
T22281 |
compound |
expression,pattern |
R6345 |
T22112 |
T22113 |
det |
the,genes |
R6346 |
T22284 |
T22281 |
prep |
of,pattern |
R6347 |
T22285 |
T22286 |
compound |
mr,s |
R6348 |
T22113 |
T22111 |
pobj |
genes,of |
R6349 |
T22286 |
T22284 |
pobj |
s,of |
R6350 |
T22287 |
T22286 |
punct |
-,s |
R6351 |
T22288 |
T22283 |
aux |
may,suggest |
R6352 |
T22114 |
T22113 |
compound |
target,genes |
R6353 |
T22289 |
T22290 |
mark |
that,expressed |
R6354 |
T22290 |
T22283 |
ccomp |
expressed,suggest |
R6355 |
T22291 |
T22292 |
compound |
mr,s |
R6356 |
T22115 |
T22103 |
prep |
during,regulates |
R6357 |
T22292 |
T22290 |
nsubjpass |
s,expressed |
R6358 |
T22293 |
T22292 |
punct |
-,s |
R6359 |
T22116 |
T22117 |
amod |
retinal,development |
R6360 |
T22294 |
T22290 |
auxpass |
is,expressed |
R6361 |
T22295 |
T22290 |
prep |
in,expressed |
R6362 |
T22296 |
T22297 |
compound |
rod,photoreceptors |
R6363 |
T22117 |
T22115 |
pobj |
development,during |
R6364 |
T22297 |
T22295 |
pobj |
photoreceptors,in |
R6365 |
T22298 |
T22295 |
cc |
but,in |
R6366 |
T22299 |
T22298 |
neg |
not,but |
R6367 |
T22118 |
T22117 |
compound |
photoreceptor,development |
R6368 |
T22300 |
T22295 |
conj |
in,in |
R6369 |
T22301 |
T22302 |
compound |
cone,photoreceptors |
R6370 |
T22302 |
T22300 |
pobj |
photoreceptors,in |
R6371 |
T22303 |
T22304 |
advmod |
as,as |
R6372 |
T22119 |
T22082 |
punct |
.,demonstrate |
R6373 |
T22304 |
T22302 |
cc |
as,photoreceptors |
R6374 |
T22305 |
T22304 |
advmod |
well,as |
R6375 |
T22306 |
T22302 |
conj |
Nr2e3,photoreceptors |
R6376 |
T22121 |
T22122 |
poss |
Our,data |
R6377 |
T22307 |
T22306 |
punct |
", ",Nr2e3 |
R6378 |
T22308 |
T22309 |
dep |
which,known |
R6379 |
T22309 |
T22306 |
relcl |
known,Nr2e3 |
R6380 |
T22310 |
T22309 |
auxpass |
is,known |
R6381 |
T22311 |
T22309 |
prep |
as,known |
R6382 |
T22312 |
T22313 |
det |
a,repressor |
R6383 |
T22313 |
T22311 |
pobj |
repressor,as |
R6384 |
T22122 |
T22123 |
nsubj |
data,revealed |
R6385 |
T22314 |
T22313 |
amod |
transcriptional,repressor |
R6386 |
T22315 |
T22309 |
cc |
and,known |
R6387 |
T22316 |
T22317 |
auxpass |
is,thought |
R6389 |
T22317 |
T22309 |
conj |
thought,known |
R6390 |
T22318 |
T22319 |
aux |
to,regulate |
R6394 |
T22320 |
T22319 |
advmod |
down,regulate |
R6396 |
T22321 |
T22319 |
punct |
-,regulate |
R6388 |
T22335 |
T22333 |
prep |
of,function |
R6391 |
T22336 |
T22337 |
compound |
mr,s |
R6392 |
T22337 |
T22335 |
pobj |
s,of |
R6393 |
T22319 |
T22317 |
xcomp |
regulate,thought |
R6395 |
T22338 |
T22337 |
punct |
-,s |
R6397 |
T22322 |
T22323 |
nmod |
cone,genes |
R6398 |
T22323 |
T22319 |
dobj |
genes,regulate |
R6399 |
T22339 |
T22331 |
punct |
", ",be |
R6400 |
T22324 |
T22325 |
npadvmod |
photoreceptor,specific |
R6401 |
T22325 |
T22323 |
amod |
specific,genes |
R6402 |
T22340 |
T22331 |
nsubj |
analysis,be |
R6403 |
T22326 |
T22325 |
punct |
-,specific |
R6404 |
T22327 |
T22283 |
punct |
.,suggest |
R6405 |
T22341 |
T22340 |
prep |
of,analysis |
R6406 |
T22329 |
T22330 |
aux |
To,clarify |
R6407 |
T22330 |
T22331 |
advcl |
clarify,be |
R6408 |
T22342 |
T22341 |
pobj |
mice,of |
R6409 |
T22332 |
T22333 |
det |
the,function |
R6410 |
T22343 |
T22342 |
prep |
with,mice |
R6411 |
T22333 |
T22330 |
dobj |
function,clarify |
R6412 |
T22334 |
T22333 |
amod |
biological,function |
R6413 |
T22344 |
T22345 |
amod |
targeted,disruptions |
R6414 |
T22345 |
T22343 |
pobj |
disruptions,with |
R6415 |
T22346 |
T22345 |
prep |
of,disruptions |
R6416 |
T22347 |
T22348 |
compound |
mr,s |
R6417 |
T22348 |
T22346 |
pobj |
s,of |
R6418 |
T22349 |
T22348 |
punct |
-,s |
R6419 |
T22350 |
T22331 |
aux |
will,be |
R6420 |
T22351 |
T22352 |
advmod |
very,important |
R6421 |
T22352 |
T22331 |
acomp |
important,be |
R6422 |
T22353 |
T22331 |
punct |
.,be |