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PMC:1435744 / 23272-24258 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12428 27-31 PR_EXT:000014441 denotes mr-s
T12429 32-39 CHEBI_PR_EXT:protein denotes protein
T12430 79-85 SO_EXT:0000417 denotes domain
T12431 96-104 GO_EXT:biological_direction_or_guidance denotes directed
T12432 105-114 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12433 141-147 SO_EXT:0000417 denotes domain
T12434 151-155 PR_EXT:000014441 denotes mr-s
T12435 181-190 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12436 191-196 SO_EXT:sequence_alteration_process denotes alter
T12437 197-205 CHEBI_EXT:residue denotes residues
T12438 215-224 SO_EXT:biological_conservation_process_or_quality denotes conserved
T12439 236-242 SO_EXT:0000417 denotes domain
T12440 290-299 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12441 341-348 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T12442 375-381 SO_EXT:0000417 denotes domain
T12443 393-400 CHEBI_PR_EXT:protein denotes protein
T12444 402-420 PR_EXT:Q9VHA0 denotes Sex comb on midleg
T12445 422-425 PR_EXT:Q9VHA0 denotes Scm
T12446 487-495 GO_EXT:biological_direction_or_guidance denotes directed
T12447 496-505 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12448 531-540 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12449 558-565 CHEBI_PR_EXT:protein denotes protein
T12450 577-583 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes tagged
T12451 596-600 PR_EXT:000014441 denotes mr-s
T12452 655-662 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T12453 713-720 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T12454 773-776 PR_EXT:000014441 denotes mrs
T12455 817-822 NCBITaxon_EXT:yeast denotes yeast
T12456 834-838 PR_EXT:P04386 denotes GAL4
T12457 864-868 PR_EXT:000014441 denotes mr-s
T12458 869-876 CHEBI_PR_EXT:protein denotes protein
T12459 918-924 SO_EXT:0000417 denotes domain
T12460 948-958 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminus
T12461 979-985 SO_EXT:0000417 denotes domain

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12275 834-838 PR:P04386 denotes GAL4
T12276 864-868 PR:000014441 denotes mr-s
T12277 918-924 SO:0000417 denotes domain
T12278 979-985 SO:0000417 denotes domain
T12265 27-31 PR:000014441 denotes mr-s
T12266 79-85 SO:0000417 denotes domain
T12267 141-147 SO:0000417 denotes domain
T12268 151-155 PR:000014441 denotes mr-s
T12269 236-242 SO:0000417 denotes domain
T12270 375-381 SO:0000417 denotes domain
T12271 402-420 PR:Q9VHA0 denotes Sex comb on midleg
T12272 422-425 PR:Q9VHA0 denotes Scm
T12273 596-600 PR:000014441 denotes mr-s
T12274 773-776 PR:000014441 denotes mrs

craft-sa-dev

Id Subject Object Predicate Lexical cue
T13284 172-173 -RRB- denotes )
T13285 173-174 . denotes .
T13286 174-432 sentence denotes These mutations alter residues that are conserved in the SAM domain of ph and previous report indicates that these mutations of ph-SAM cause significant reduction in binding activity to the other SAM domain-containing protein, Sex comb on midleg (Scm) (41).
T13287 175-180 DT denotes These
T13288 181-190 NNS denotes mutations
T13289 191-196 VBP denotes alter
T13290 197-205 NNS denotes residues
T13291 206-210 WDT denotes that
T13292 215-224 VBN denotes conserved
T13293 211-214 VBP denotes are
T13294 225-227 IN denotes in
T13295 228-231 DT denotes the
T13296 236-242 NN denotes domain
T13297 232-235 NN denotes SAM
T13298 243-245 IN denotes of
T13299 246-248 NN denotes ph
T13300 249-252 CC denotes and
T13301 253-261 JJ denotes previous
T13302 262-268 NN denotes report
T13303 269-278 VBZ denotes indicates
T13304 279-283 IN denotes that
T13305 310-315 VBP denotes cause
T13306 284-289 DT denotes these
T13307 290-299 NNS denotes mutations
T13308 300-302 IN denotes of
T13309 303-305 NN denotes ph
T13310 306-309 NN denotes SAM
T13311 305-306 HYPH denotes -
T13312 316-327 JJ denotes significant
T13313 328-337 NN denotes reduction
T13314 338-340 IN denotes in
T13315 341-348 NN denotes binding
T13316 349-357 NN denotes activity
T13317 358-360 IN denotes to
T13318 361-364 DT denotes the
T13319 393-400 NN denotes protein
T13320 365-370 JJ denotes other
T13321 371-374 NN denotes SAM
T13322 375-381 NN denotes domain
T13323 382-392 VBG denotes containing
T13324 381-382 HYPH denotes -
T13325 400-402 , denotes ,
T13326 402-405 NN denotes Sex
T13327 406-410 NN denotes comb
T13328 411-413 IN denotes on
T13329 414-420 NN denotes midleg
T13330 421-422 -LRB- denotes (
T13331 422-425 NN denotes Scm
T13332 425-426 -RRB- denotes )
T13333 427-428 -LRB- denotes (
T13334 428-430 CD denotes 41
T13335 430-431 -RRB- denotes )
T13336 431-432 . denotes .
T13337 432-629 sentence denotes Based on this result, we introduced two types of site-directed mutations, which correspond to the mutations introduced in ph protein, into Flag-tagged full-length mr-s (Flag-W404A and Flag-G453A).
T13338 433-438 VBN denotes Based
T13339 458-468 VBD denotes introduced
T13340 439-441 IN denotes on
T13341 442-446 DT denotes this
T13342 447-453 NN denotes result
T13343 453-455 , denotes ,
T13344 455-457 PRP denotes we
T13345 469-472 CD denotes two
T13346 473-478 NNS denotes types
T13347 479-481 IN denotes of
T13348 482-486 NN denotes site
T13349 487-495 VBN denotes directed
T13350 486-487 HYPH denotes -
T13351 496-505 NNS denotes mutations
T13352 505-507 , denotes ,
T13353 507-512 WDT denotes which
T13354 513-523 VBP denotes correspond
T13355 524-526 IN denotes to
T13356 527-530 DT denotes the
T13357 531-540 NNS denotes mutations
T13358 541-551 VBN denotes introduced
T13359 552-554 IN denotes in
T13360 555-557 NN denotes ph
T13361 558-565 NN denotes protein
T13362 565-567 , denotes ,
T13363 567-571 IN denotes into
T13364 572-576 NN denotes Flag
T13365 577-583 VBN denotes tagged
T13366 576-577 HYPH denotes -
T13367 599-600 NN denotes s
T13368 584-588 JJ denotes full
T13369 589-595 NN denotes length
T13370 588-589 HYPH denotes -
T13371 596-598 NN denotes mr
T13372 598-599 HYPH denotes -
T13373 601-602 -LRB- denotes (
T13374 602-606 NN denotes Flag
T13375 607-612 NN denotes W404A
T13376 606-607 HYPH denotes -
T13377 613-616 CC denotes and
T13378 617-621 NN denotes Flag
T13379 622-627 NN denotes G453A
T13380 621-622 HYPH denotes -
T13381 627-628 -RRB- denotes )
T13382 628-629 . denotes .
T13383 629-787 sentence denotes We found that Flag-W404A binding activity was significantly reduced and Flag-G453A binding activity was also slightly reduced compared to Flag-mrs (Fig. 5C).
T13384 630-632 PRP denotes We
T13385 633-638 VBD denotes found
T13386 639-643 IN denotes that
T13387 690-697 VBN denotes reduced
T13388 644-648 NN denotes Flag
T13389 649-654 NN denotes W404A
T13390 648-649 HYPH denotes -
T13391 655-662 NN denotes binding
T13392 663-671 NN denotes activity
T13393 672-675 VBD denotes was
T13394 676-689 RB denotes significantly
T13395 698-701 CC denotes and
T13396 702-706 NN denotes Flag
T13397 707-712 NN denotes G453A
T13398 706-707 HYPH denotes -
T13399 713-720 NN denotes binding
T13400 721-729 NN denotes activity
T13401 748-755 VBN denotes reduced
T13402 730-733 VBD denotes was
T13403 734-738 RB denotes also
T13404 739-747 RB denotes slightly
T13405 756-764 VBN denotes compared
T13406 765-767 IN denotes to
T13407 768-772 NN denotes Flag
T13408 773-776 NN denotes mrs
T13409 772-773 HYPH denotes -
T13410 777-778 -LRB- denotes (
T13411 783-785 NN denotes 5C
T13412 778-782 NN denotes Fig.
T13413 785-786 -RRB- denotes )
T13414 786-787 . denotes .
T13415 787-986 sentence denotes These results, together with yeast two-hybrid GAL4 assay, indicate that the mr-s protein self-associates strongly through its SAM domain and weakly through the N-terminus portion lacking SAM domain.
T13416 788-793 DT denotes These
T13417 794-801 NNS denotes results
T13418 846-854 VBP denotes indicate
T13419 801-803 , denotes ,
T13420 803-811 RB denotes together
T13421 812-816 IN denotes with
T13422 817-822 NN denotes yeast
T13423 839-844 NN denotes assay
T13424 823-826 CD denotes two
T13425 827-833 NN denotes hybrid
T13426 826-827 HYPH denotes -
T13427 834-838 NN denotes GAL4
T13428 844-846 , denotes ,
T13429 855-859 IN denotes that
T13430 882-892 VBZ denotes associates
T13431 860-863 DT denotes the
T13432 869-876 NN denotes protein
T13433 864-866 NN denotes mr
T13434 867-868 NN denotes s
T13435 866-867 HYPH denotes -
T13436 877-881 NN denotes self
T13437 881-882 HYPH denotes -
T13438 893-901 RB denotes strongly
T13439 902-909 IN denotes through
T13440 910-913 PRP$ denotes its
T13441 918-924 NN denotes domain
T13442 914-917 NN denotes SAM
T13443 925-928 CC denotes and
T13444 929-935 RB denotes weakly
T13445 936-943 IN denotes through
T13446 944-947 DT denotes the
T13447 959-966 NN denotes portion
T13448 948-949 NN denotes N
T13449 950-958 NN denotes terminus
T13450 949-950 HYPH denotes -
T13451 967-974 VBG denotes lacking
T13452 975-978 NN denotes SAM
T13453 979-985 NN denotes domain
T13454 985-986 . denotes .
T13281 157-161 NN denotes Fig.
T13282 162-164 NN denotes 1B
T13283 164-166 , denotes ,
T13247 0-2 TO denotes To
T13248 3-14 VB denotes investigate
T13249 120-129 VBN denotes generated
T13250 15-22 IN denotes whether
T13251 45-55 VBZ denotes associates
T13252 23-26 DT denotes the
T13253 32-39 NN denotes protein
T13254 27-29 NN denotes mr
T13255 30-31 NN denotes s
T13256 29-30 HYPH denotes -
T13257 40-44 NN denotes self
T13258 44-45 HYPH denotes -
T13259 56-62 RB denotes mainly
T13260 63-70 IN denotes through
T13261 71-74 DT denotes the
T13262 79-85 NN denotes domain
T13263 75-78 NN denotes SAM
T13264 85-87 , denotes ,
T13265 87-90 CD denotes two
T13266 105-114 NNS denotes mutations
T13267 91-95 NN denotes site
T13268 96-104 VBN denotes directed
T13269 95-96 HYPH denotes -
T13270 115-119 VBD denotes were
T13271 130-132 IN denotes in
T13272 133-136 DT denotes the
T13273 141-147 NN denotes domain
T13274 137-140 NN denotes SAM
T13275 148-150 IN denotes of
T13276 151-153 NN denotes mr
T13277 154-155 NN denotes s
T13278 153-154 HYPH denotes -
T13279 156-157 -LRB- denotes (
T13280 166-172 NNS denotes arrows
R3591 T13277 T13275 pobj s,of
R3593 T13278 T13277 punct -,s
R3594 T13279 T13280 punct (,arrows
R3595 T13280 T13249 parataxis arrows,generated
R3596 T13281 T13282 compound Fig.,1B
R3597 T13282 T13280 dep 1B,arrows
R3599 T13283 T13280 punct ", ",arrows
R3602 T13284 T13280 punct ),arrows
R3604 T13285 T13249 punct .,generated
R3606 T13287 T13288 det These,mutations
R3607 T13288 T13289 nsubj mutations,alter
R3609 T13290 T13289 dobj residues,alter
R3610 T13291 T13292 dep that,conserved
R3612 T13292 T13290 relcl conserved,residues
R3613 T13293 T13292 auxpass are,conserved
R3614 T13294 T13292 prep in,conserved
R3616 T13295 T13296 det the,domain
R3617 T13296 T13294 pobj domain,in
R3618 T13297 T13296 compound SAM,domain
R3620 T13298 T13296 prep of,domain
R3621 T13299 T13298 pobj ph,of
R3622 T13300 T13289 cc and,alter
R3624 T13301 T13302 amod previous,report
R3625 T13302 T13303 nsubj report,indicates
R3626 T13303 T13289 conj indicates,alter
R3627 T13304 T13305 mark that,cause
R3629 T13305 T13303 ccomp cause,indicates
R3630 T13306 T13307 det these,mutations
R3632 T13307 T13305 nsubj mutations,cause
R3633 T13308 T13307 prep of,mutations
R3635 T13309 T13310 compound ph,SAM
R3636 T13310 T13308 pobj SAM,of
R3637 T13311 T13310 punct -,SAM
R3639 T13312 T13313 amod significant,reduction
R3640 T13313 T13305 dobj reduction,cause
R3641 T13314 T13313 prep in,reduction
R3643 T13315 T13316 compound binding,activity
R3644 T13316 T13314 pobj activity,in
R3645 T13317 T13316 prep to,activity
R3647 T13318 T13319 det the,protein
R3648 T13319 T13317 pobj protein,to
R3649 T13320 T13319 amod other,protein
R3650 T13321 T13322 compound SAM,domain
R3651 T13322 T13323 npadvmod domain,containing
R3653 T13323 T13319 amod containing,protein
R3654 T13324 T13323 punct -,containing
R3655 T13325 T13319 punct ", ",protein
R3656 T13326 T13327 compound Sex,comb
R3658 T13327 T13319 appos comb,protein
R3659 T13328 T13327 prep on,comb
R3660 T13329 T13328 pobj midleg,on
R3662 T13330 T13327 punct (,comb
R3663 T13331 T13327 appos Scm,comb
R3665 T13332 T13305 punct ),cause
R3666 T13333 T13334 punct (,41
R3667 T13334 T13305 parataxis 41,cause
R3669 T13335 T13334 punct ),41
R3670 T13336 T13303 punct .,indicates
R3672 T13338 T13339 prep Based,introduced
R3674 T13340 T13338 prep on,Based
R3675 T13341 T13342 det this,result
R3676 T13342 T13340 pobj result,on
R3678 T13343 T13339 punct ", ",introduced
R3679 T13344 T13339 nsubj we,introduced
R3680 T13345 T13346 nummod two,types
R3682 T13346 T13339 dobj types,introduced
R3683 T13347 T13346 prep of,types
R3684 T13348 T13349 npadvmod site,directed
R3686 T13349 T13351 amod directed,mutations
R3687 T13350 T13349 punct -,directed
R3689 T13351 T13347 pobj mutations,of
R3690 T13352 T13346 punct ", ",types
R3692 T13353 T13354 dep which,correspond
R3693 T13354 T13346 relcl correspond,types
R3694 T13355 T13354 prep to,correspond
R3696 T13356 T13357 det the,mutations
R3697 T13357 T13355 pobj mutations,to
R3698 T13358 T13357 acl introduced,mutations
R3700 T13359 T13358 prep in,introduced
R3701 T13360 T13361 compound ph,protein
R3702 T13361 T13359 pobj protein,in
R3704 T13362 T13358 punct ", ",introduced
R3706 T13363 T13358 prep into,introduced
R3707 T13364 T13365 npadvmod Flag,tagged
R3708 T13365 T13367 amod tagged,s
R3710 T13366 T13365 punct -,tagged
R3711 T13367 T13363 pobj s,into
R3713 T13368 T13369 amod full,length
R3714 T13369 T13367 compound length,s
R3715 T13370 T13369 punct -,length
R3717 T13371 T13367 compound mr,s
R3718 T13372 T13367 punct -,s
R3719 T13373 T13346 punct (,types
R3721 T13374 T13375 compound Flag,W404A
R3722 T13375 T13346 appos W404A,types
R3723 T13376 T13375 punct -,W404A
R3725 T13377 T13375 cc and,W404A
R3726 T13378 T13379 compound Flag,G453A
R3727 T13379 T13375 conj G453A,W404A
R3729 T13380 T13379 punct -,G453A
R3730 T13381 T13339 punct ),introduced
R3731 T13382 T13339 punct .,introduced
R3733 T13384 T13385 nsubj We,found
R3736 T13386 T13387 mark that,reduced
R3737 T13387 T13385 ccomp reduced,found
R3738 T13388 T13389 compound Flag,W404A
R3740 T13389 T13391 compound W404A,binding
R3741 T13390 T13389 punct -,W404A
R3742 T13391 T13392 compound binding,activity
R3743 T13392 T13387 nsubjpass activity,reduced
R3744 T13393 T13387 auxpass was,reduced
R3745 T13394 T13387 advmod significantly,reduced
R3746 T13395 T13385 cc and,found
R3747 T13396 T13397 compound Flag,G453A
R3748 T13397 T13399 compound G453A,binding
R3749 T13398 T13397 punct -,G453A
R3750 T13399 T13400 compound binding,activity
R3751 T13400 T13401 nsubjpass activity,reduced
R3752 T13401 T13385 conj reduced,found
R3753 T13402 T13401 auxpass was,reduced
R3754 T13403 T13401 advmod also,reduced
R3755 T13404 T13401 advmod slightly,reduced
R3756 T13405 T13401 prep compared,reduced
R3757 T13406 T13405 prep to,compared
R3758 T13407 T13408 compound Flag,mrs
R3759 T13408 T13406 pobj mrs,to
R3760 T13409 T13408 punct -,mrs
R3761 T13410 T13411 punct (,5C
R3762 T13411 T13401 parataxis 5C,reduced
R3763 T13412 T13411 compound Fig.,5C
R3764 T13413 T13411 punct ),5C
R3765 T13414 T13401 punct .,reduced
R3766 T13416 T13417 det These,results
R3767 T13417 T13418 nsubj results,indicate
R3768 T13419 T13418 punct ", ",indicate
R3769 T13420 T13418 advmod together,indicate
R3770 T13421 T13420 prep with,together
R3771 T13422 T13423 nmod yeast,assay
R3772 T13423 T13421 pobj assay,with
R3773 T13424 T13425 nummod two,hybrid
R3774 T13425 T13423 compound hybrid,assay
R3775 T13426 T13425 punct -,hybrid
R3776 T13427 T13423 compound GAL4,assay
R3777 T13428 T13418 punct ", ",indicate
R3778 T13429 T13430 mark that,associates
R3779 T13430 T13418 ccomp associates,indicate
R3780 T13431 T13432 det the,protein
R3781 T13432 T13430 nsubj protein,associates
R3782 T13433 T13434 compound mr,s
R3783 T13434 T13432 compound s,protein
R3784 T13435 T13434 punct -,s
R3785 T13436 T13430 dep self,associates
R3786 T13437 T13430 punct -,associates
R3787 T13438 T13430 advmod strongly,associates
R3788 T13439 T13430 prep through,associates
R3789 T13440 T13441 poss its,domain
R3790 T13441 T13439 pobj domain,through
R3791 T13442 T13441 compound SAM,domain
R3792 T13443 T13430 cc and,associates
R3793 T13444 T13430 conj weakly,associates
R3794 T13445 T13444 prep through,weakly
R3795 T13446 T13447 det the,portion
R3796 T13447 T13445 pobj portion,through
R3797 T13448 T13449 compound N,terminus
R3798 T13449 T13447 compound terminus,portion
R3799 T13450 T13449 punct -,terminus
R3800 T13451 T13447 acl lacking,portion
R3801 T13452 T13453 compound SAM,domain
R3802 T13453 T13451 dobj domain,lacking
R3803 T13454 T13418 punct .,indicate
R3549 T13247 T13248 aux To,investigate
R3551 T13248 T13249 advcl investigate,generated
R3553 T13250 T13251 mark whether,associates
R3554 T13251 T13248 ccomp associates,investigate
R3556 T13252 T13253 det the,protein
R3557 T13253 T13251 nsubj protein,associates
R3558 T13254 T13255 compound mr,s
R3560 T13255 T13253 compound s,protein
R3561 T13256 T13255 punct -,s
R3563 T13257 T13251 dep self,associates
R3564 T13258 T13251 punct -,associates
R3565 T13259 T13251 advmod mainly,associates
R3567 T13260 T13251 prep through,associates
R3568 T13261 T13262 det the,domain
R3569 T13262 T13260 pobj domain,through
R3571 T13263 T13262 compound SAM,domain
R3572 T13264 T13249 punct ", ",generated
R3574 T13265 T13266 nummod two,mutations
R3575 T13266 T13249 nsubjpass mutations,generated
R3576 T13267 T13268 npadvmod site,directed
R3578 T13268 T13266 amod directed,mutations
R3579 T13269 T13268 punct -,directed
R3580 T13270 T13249 auxpass were,generated
R3582 T13271 T13249 prep in,generated
R3583 T13272 T13273 det the,domain
R3584 T13273 T13271 pobj domain,in
R3586 T13274 T13273 compound SAM,domain
R3587 T13275 T13273 prep of,domain
R3588 T13276 T13277 compound mr,s