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PMC:1420314 / 4587-5504 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3162 0-4 NCBITaxon:10088 denotes Mice
T3163 43-49 PR:000003710 denotes Adam11
T3164 50-54 SO:0000704 denotes gene
T3165 225-242 SO:0000319 denotes termination codon
T3166 261-265 SO:0000147 denotes exon
T3167 275-286 SO:0001062 denotes pro-protein
T3168 287-293 SO:0000417 denotes domain
T3169 326-332 PR:000003710 denotes ADAM11
T3170 381-387 SO:0001023 denotes allele
T3171 397-408 SO:0001062 denotes pro-protein
T3172 409-416 SO:0000417 denotes domains
T3173 474-479 PR:000003137 denotes furin
T3174 579-585 PR:000003710 denotes ADAM11
T3175 641-647 PR:000003710 denotes ADAM11
T3176 734-742 GO:0042571 denotes antibody
T3177 763-769 PR:000003710 denotes ADAM11
T3178 902-908 PR:000003710 denotes ADAM11

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3181 0-4 NCBITaxon:10088 denotes Mice
T3182 25-33 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3183 43-49 PR_EXT:000003710 denotes Adam11
T3184 50-54 SO_EXT:0000704 denotes gene
T3185 84-97 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3186 225-242 SO_EXT:0000319 denotes termination codon
T3187 261-265 SO_EXT:0000147 denotes exon
T3188 275-286 SO_EXT:0001062 denotes pro-protein
T3189 279-286 CHEBI_PR_EXT:protein denotes protein
T3190 287-293 SO_EXT:0000417 denotes domain
T3191 304-313 SO_EXT:sequence_truncation_process denotes truncated
T3192 326-332 PR_EXT:000003710 denotes ADAM11
T3193 333-340 CHEBI_PR_EXT:protein denotes protein
T3194 381-387 SO_EXT:0001023 denotes allele
T3195 397-408 SO_EXT:0001062 denotes pro-protein
T3196 401-408 CHEBI_PR_EXT:protein denotes protein
T3197 409-416 SO_EXT:0000417 denotes domains
T3198 462-470 CHEBI_PR_EXT:protein denotes proteins
T3199 474-479 PR_EXT:000003137 denotes furin
T3200 485-494 GO_EXT:0008233 denotes proteases
T3201 561-570 SO_EXT:sequence_truncation_process denotes truncated
T3202 579-585 PR_EXT:000003710 denotes ADAM11
T3203 586-593 CHEBI_PR_EXT:protein denotes protein
T3204 641-647 PR_EXT:000003710 denotes ADAM11
T3205 648-655 CHEBI_PR_EXT:protein denotes protein
T3206 670-677 SO_EXT:sequence_altered_entity denotes mutants
T3207 734-742 GO:0042571 denotes antibody
T3208 763-769 PR_EXT:000003710 denotes ADAM11
T3209 770-777 CHEBI_PR_EXT:protein denotes protein
T3210 839-846 SO_EXT:sequence_altered_entity denotes mutants
T3211 882-891 SO_EXT:wild_type_entity_or_quality denotes wild-type
T3212 902-908 PR_EXT:000003710 denotes ADAM11
T3213 909-916 CHEBI_PR_EXT:protein denotes protein

craft-sa-dev

Id Subject Object Predicate Lexical cue
T3287 347-349 VB denotes be
T3221 0-4 NNS denotes Mice
T3222 60-69 VBN denotes generated
T3223 5-13 VBG denotes carrying
T3224 14-15 DT denotes a
T3225 25-33 NN denotes mutation
T3226 16-24 VBN denotes targeted
T3227 34-36 IN denotes in
T3228 37-42 PRP$ denotes their
T3229 50-54 NN denotes gene
T3230 43-49 NN denotes Adam11
T3231 55-59 VBD denotes were
T3232 70-72 IN denotes by
T3233 73-83 JJ denotes homologous
T3234 84-97 NN denotes recombination
T3235 98-99 -LRB- denotes (
T3236 104-106 NN denotes 1A
T3237 99-103 NN denotes Fig.
T3238 106-107 -RRB- denotes )
T3239 107-108 . denotes .
T3240 108-185 sentence denotes Correct targeting events were confirmed by Southern blot analysis (Fig. 1B).
T3241 109-116 JJ denotes Correct
T3242 127-133 NNS denotes events
T3243 117-126 NN denotes targeting
T3244 139-148 VBN denotes confirmed
T3245 134-138 VBD denotes were
T3246 149-151 IN denotes by
T3247 152-160 NNP denotes Southern
T3248 161-165 NN denotes blot
T3249 166-174 NN denotes analysis
T3250 175-176 -LRB- denotes (
T3251 181-183 NN denotes 1B
T3252 176-180 NN denotes Fig.
T3253 183-184 -RRB- denotes )
T3254 184-185 . denotes .
T3255 185-388 sentence denotes As a result of this procedure, since a termination codon was introduced in exon 5 in the pro-protein domain, only the truncated form of the ADAM11 protein would be synthesised from this targeted allele.
T3256 186-188 IN denotes As
T3257 350-361 VBN denotes synthesised
T3258 189-190 DT denotes a
T3259 191-197 NN denotes result
T3260 198-200 IN denotes of
T3261 201-205 DT denotes this
T3262 206-215 NN denotes procedure
T3263 215-217 , denotes ,
T3264 217-222 IN denotes since
T3265 247-257 VBN denotes introduced
T3266 223-224 DT denotes a
T3267 237-242 NN denotes codon
T3268 225-236 NN denotes termination
T3269 243-246 VBD denotes was
T3270 258-260 IN denotes in
T3271 261-265 NN denotes exon
T3272 266-267 CD denotes 5
T3273 268-270 IN denotes in
T3274 271-274 DT denotes the
T3275 287-293 NN denotes domain
T3276 275-286 JJ denotes pro-protein
T3277 293-295 , denotes ,
T3278 295-299 RB denotes only
T3279 314-318 NN denotes form
T3280 300-303 DT denotes the
T3281 304-313 VBN denotes truncated
T3282 319-321 IN denotes of
T3283 322-325 DT denotes the
T3284 333-340 NN denotes protein
T3285 326-332 NN denotes ADAM11
T3286 341-346 MD denotes would
T3288 362-366 IN denotes from
T3289 367-371 DT denotes this
T3290 381-387 NN denotes allele
T3291 372-380 VBN denotes targeted
T3292 387-388 . denotes .
T3293 388-622 sentence denotes Because pro-protein domains are always removed in mature functional ADAM-proteins by furin-like proteases and are thus thought to be non-functional, we concluded that this truncated form of ADAM11 protein would have no function [26].
T3294 389-396 IN denotes Because
T3295 428-435 VBN denotes removed
T3296 397-408 JJ denotes pro-protein
T3297 409-416 NNS denotes domains
T3298 417-420 VBP denotes are
T3299 421-427 RB denotes always
T3300 541-550 VBD denotes concluded
T3301 436-438 IN denotes in
T3302 439-445 JJ denotes mature
T3303 462-470 NN denotes proteins
T3304 446-456 JJ denotes functional
T3305 457-461 NN denotes ADAM
T3306 461-462 HYPH denotes -
T3307 471-473 IN denotes by
T3308 474-479 NN denotes furin
T3309 480-484 JJ denotes like
T3310 479-480 HYPH denotes -
T3311 485-494 NNS denotes proteases
T3312 495-498 CC denotes and
T3313 499-502 VBP denotes are
T3314 508-515 VBN denotes thought
T3315 503-507 RB denotes thus
T3316 516-518 TO denotes to
T3317 519-521 VB denotes be
T3318 522-536 JJ denotes non-functional
T3319 536-538 , denotes ,
T3320 538-540 PRP denotes we
T3321 551-555 IN denotes that
T3322 600-604 VB denotes have
T3323 556-560 DT denotes this
T3324 571-575 NN denotes form
T3325 561-570 VBN denotes truncated
T3326 576-578 IN denotes of
T3327 579-585 NN denotes ADAM11
T3328 586-593 NN denotes protein
T3329 594-599 MD denotes would
T3330 605-607 DT denotes no
T3331 608-616 NN denotes function
T3332 617-618 -LRB- denotes [
T3333 618-620 CD denotes 26
T3334 620-621 -RRB- denotes ]
T3335 621-622 . denotes .
T3336 622-788 sentence denotes Absence of mature ADAM11 protein in homozygous mutants was confirmed by Western blot analysis using a specific antibody that recognises the ADAM11 protein (Fig. 1C).
T3337 623-630 NN denotes Absence
T3338 682-691 VBN denotes confirmed
T3339 631-633 IN denotes of
T3340 634-640 JJ denotes mature
T3341 648-655 NN denotes protein
T3342 641-647 NN denotes ADAM11
T3343 656-658 IN denotes in
T3344 659-669 JJ denotes homozygous
T3345 670-677 NNS denotes mutants
T3346 678-681 VBD denotes was
T3347 692-694 IN denotes by
T3348 695-702 NNP denotes Western
T3349 703-707 NN denotes blot
T3350 708-716 NN denotes analysis
T3351 717-722 VBG denotes using
T3352 723-724 DT denotes a
T3353 734-742 NN denotes antibody
T3354 725-733 JJ denotes specific
T3355 743-747 WDT denotes that
T3356 748-758 VBZ denotes recognises
T3357 759-762 DT denotes the
T3358 770-777 NN denotes protein
T3359 763-769 NN denotes ADAM11
T3360 778-779 -LRB- denotes (
T3361 784-786 NN denotes 1C
T3362 779-783 NN denotes Fig.
T3363 786-787 -RRB- denotes )
T3364 787-788 . denotes .
T3365 788-917 sentence denotes Analysis by Western blot showed that heterozygous mutants produced approximately half of the wild-type levels of ADAM11 protein.
T3366 789-797 NN denotes Analysis
T3367 814-820 VBD denotes showed
T3368 798-800 IN denotes by
T3369 801-808 NNP denotes Western
T3370 809-813 NN denotes blot
T3371 821-825 IN denotes that
T3372 847-855 VBD denotes produced
T3373 826-838 JJ denotes heterozygous
T3374 839-846 NNS denotes mutants
T3375 856-869 RB denotes approximately
T3376 870-874 NN denotes half
T3377 875-877 IN denotes of
T3378 878-881 DT denotes the
T3379 892-898 NNS denotes levels
T3380 882-886 JJ denotes wild
T3381 887-891 NN denotes type
T3382 886-887 HYPH denotes -
T3383 899-901 IN denotes of
T3384 902-908 NN denotes ADAM11
T3385 909-916 NN denotes protein
T3386 916-917 . denotes .
R806 T3221 T3222 nsubjpass Mice,generated
R807 T3223 T3221 acl carrying,Mice
R808 T3224 T3225 det a,mutation
R809 T3225 T3223 dobj mutation,carrying
R810 T3226 T3225 amod targeted,mutation
R811 T3227 T3223 prep in,carrying
R812 T3228 T3229 poss their,gene
R813 T3229 T3227 pobj gene,in
R814 T3230 T3229 compound Adam11,gene
R815 T3231 T3222 auxpass were,generated
R816 T3232 T3222 prep by,generated
R817 T3233 T3234 amod homologous,recombination
R818 T3234 T3232 pobj recombination,by
R819 T3235 T3236 punct (,1A
R820 T3236 T3222 parataxis 1A,generated
R821 T3237 T3236 compound Fig.,1A
R822 T3238 T3236 punct ),1A
R823 T3239 T3222 punct .,generated
R824 T3241 T3242 amod Correct,events
R825 T3242 T3244 nsubjpass events,confirmed
R826 T3243 T3242 compound targeting,events
R827 T3245 T3244 auxpass were,confirmed
R828 T3246 T3244 agent by,confirmed
R829 T3247 T3248 compound Southern,blot
R830 T3248 T3249 compound blot,analysis
R831 T3249 T3246 pobj analysis,by
R832 T3250 T3251 punct (,1B
R833 T3251 T3244 parataxis 1B,confirmed
R834 T3252 T3251 compound Fig.,1B
R835 T3253 T3251 punct ),1B
R836 T3254 T3244 punct .,confirmed
R837 T3256 T3257 prep As,synthesised
R838 T3258 T3259 det a,result
R839 T3259 T3256 pobj result,As
R840 T3260 T3259 prep of,result
R841 T3261 T3262 det this,procedure
R842 T3262 T3260 pobj procedure,of
R843 T3263 T3257 punct ", ",synthesised
R844 T3264 T3265 mark since,introduced
R846 T3266 T3267 det a,codon
R847 T3267 T3265 nsubjpass codon,introduced
R848 T3268 T3267 compound termination,codon
R849 T3269 T3265 auxpass was,introduced
R850 T3270 T3265 prep in,introduced
R851 T3271 T3270 pobj exon,in
R852 T3272 T3271 nummod 5,exon
R853 T3273 T3265 prep in,introduced
R854 T3274 T3275 det the,domain
R855 T3275 T3273 pobj domain,in
R856 T3276 T3275 amod pro-protein,domain
R857 T3277 T3257 punct ", ",synthesised
R858 T3278 T3279 advmod only,form
R859 T3279 T3257 nsubjpass form,synthesised
R860 T3280 T3279 det the,form
R861 T3281 T3279 amod truncated,form
R862 T3282 T3279 prep of,form
R863 T3283 T3284 det the,protein
R864 T3284 T3282 pobj protein,of
R865 T3285 T3284 compound ADAM11,protein
R866 T3286 T3257 aux would,synthesised
R867 T3287 T3257 auxpass be,synthesised
R868 T3288 T3257 prep from,synthesised
R869 T3289 T3290 det this,allele
R870 T3290 T3288 pobj allele,from
R871 T3291 T3290 amod targeted,allele
R872 T3292 T3257 punct .,synthesised
R873 T3294 T3295 mark Because,removed
R875 T3296 T3297 amod pro-protein,domains
R876 T3297 T3295 nsubjpass domains,removed
R877 T3298 T3295 auxpass are,removed
R878 T3299 T3295 advmod always,removed
R879 T3301 T3295 prep in,removed
R880 T3302 T3303 amod mature,proteins
R881 T3303 T3301 pobj proteins,in
R882 T3304 T3303 amod functional,proteins
R883 T3305 T3303 compound ADAM,proteins
R884 T3306 T3303 punct -,proteins
R885 T3307 T3295 agent by,removed
R886 T3308 T3309 npadvmod furin,like
R887 T3309 T3311 amod like,proteases
R888 T3310 T3309 punct -,like
R889 T3311 T3307 pobj proteases,by
R890 T3312 T3295 cc and,removed
R891 T3313 T3314 auxpass are,thought
R892 T3314 T3295 conj thought,removed
R893 T3315 T3314 advmod thus,thought
R894 T3316 T3317 aux to,be
R895 T3317 T3314 xcomp be,thought
R896 T3318 T3317 acomp non-functional,be
R897 T3319 T3300 punct ", ",concluded
R898 T3320 T3300 nsubj we,concluded
R899 T3321 T3322 mark that,have
R900 T3322 T3300 ccomp have,concluded
R901 T3323 T3324 det this,form
R902 T3324 T3322 nsubj form,have
R903 T3325 T3324 amod truncated,form
R904 T3326 T3324 prep of,form
R905 T3327 T3328 compound ADAM11,protein
R906 T3328 T3326 pobj protein,of
R907 T3329 T3322 aux would,have
R908 T3330 T3331 det no,function
R909 T3331 T3322 dobj function,have
R910 T3332 T3333 punct [,26
R911 T3333 T3322 parataxis 26,have
R912 T3334 T3333 punct ],26
R913 T3335 T3300 punct .,concluded
R914 T3337 T3338 nsubjpass Absence,confirmed
R915 T3339 T3337 prep of,Absence
R916 T3340 T3341 amod mature,protein
R917 T3341 T3339 pobj protein,of
R918 T3342 T3341 compound ADAM11,protein
R919 T3343 T3337 prep in,Absence
R920 T3344 T3345 amod homozygous,mutants
R921 T3345 T3343 pobj mutants,in
R922 T3346 T3338 auxpass was,confirmed
R923 T3347 T3338 prep by,confirmed
R924 T3348 T3349 compound Western,blot
R925 T3349 T3350 compound blot,analysis
R926 T3350 T3347 pobj analysis,by
R927 T3351 T3350 acl using,analysis
R928 T3352 T3353 det a,antibody
R929 T3353 T3351 dobj antibody,using
R930 T3354 T3353 amod specific,antibody
R931 T3355 T3356 dep that,recognises
R932 T3356 T3353 relcl recognises,antibody
R933 T3357 T3358 det the,protein
R934 T3358 T3356 dobj protein,recognises
R935 T3359 T3358 compound ADAM11,protein
R936 T3360 T3361 punct (,1C
R937 T3361 T3338 parataxis 1C,confirmed
R938 T3362 T3361 compound Fig.,1C
R939 T3363 T3361 punct ),1C
R940 T3364 T3338 punct .,confirmed
R941 T3366 T3367 nsubj Analysis,showed
R942 T3368 T3366 prep by,Analysis
R943 T3369 T3370 compound Western,blot
R944 T3370 T3368 pobj blot,by
R945 T3371 T3372 mark that,produced
R946 T3372 T3367 ccomp produced,showed
R947 T3373 T3374 amod heterozygous,mutants
R948 T3374 T3372 nsubj mutants,produced
R949 T3375 T3376 advmod approximately,half
R950 T3376 T3372 dobj half,produced
R951 T3377 T3376 prep of,half
R952 T3378 T3379 det the,levels
R953 T3379 T3377 pobj levels,of
R954 T3380 T3381 amod wild,type
R955 T3381 T3379 compound type,levels
R956 T3382 T3381 punct -,type
R957 T3383 T3379 prep of,levels
R958 T3384 T3385 compound ADAM11,protein
R959 T3385 T3383 pobj protein,of
R960 T3386 T3367 punct .,showed
R845 T3265 T3257 advcl introduced,synthesised
R874 T3295 T3300 advcl removed,concluded