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PMC:1420314 / 4551-5504 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3160 14-20 PR:000003710 denotes ADAM11
T3161 31-35 NCBITaxon:10088 denotes mice
T3162 36-40 NCBITaxon:10088 denotes Mice
T3163 79-85 PR:000003710 denotes Adam11
T3164 86-90 SO:0000704 denotes gene
T3165 261-278 SO:0000319 denotes termination codon
T3166 297-301 SO:0000147 denotes exon
T3167 311-322 SO:0001062 denotes pro-protein
T3168 323-329 SO:0000417 denotes domain
T3169 362-368 PR:000003710 denotes ADAM11
T3170 417-423 SO:0001023 denotes allele
T3171 433-444 SO:0001062 denotes pro-protein
T3172 445-452 SO:0000417 denotes domains
T3173 510-515 PR:000003137 denotes furin
T3174 615-621 PR:000003710 denotes ADAM11
T3175 677-683 PR:000003710 denotes ADAM11
T3176 770-778 GO:0042571 denotes antibody
T3177 799-805 PR:000003710 denotes ADAM11
T3178 938-944 PR:000003710 denotes ADAM11

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3179 14-20 PR_EXT:000003710 denotes ADAM11
T3180 31-35 NCBITaxon:10088 denotes mice
T3181 36-40 NCBITaxon:10088 denotes Mice
T3182 61-69 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3183 79-85 PR_EXT:000003710 denotes Adam11
T3184 86-90 SO_EXT:0000704 denotes gene
T3185 120-133 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3186 261-278 SO_EXT:0000319 denotes termination codon
T3187 297-301 SO_EXT:0000147 denotes exon
T3188 311-322 SO_EXT:0001062 denotes pro-protein
T3189 315-322 CHEBI_PR_EXT:protein denotes protein
T3190 323-329 SO_EXT:0000417 denotes domain
T3191 340-349 SO_EXT:sequence_truncation_process denotes truncated
T3192 362-368 PR_EXT:000003710 denotes ADAM11
T3193 369-376 CHEBI_PR_EXT:protein denotes protein
T3194 417-423 SO_EXT:0001023 denotes allele
T3195 433-444 SO_EXT:0001062 denotes pro-protein
T3196 437-444 CHEBI_PR_EXT:protein denotes protein
T3197 445-452 SO_EXT:0000417 denotes domains
T3198 498-506 CHEBI_PR_EXT:protein denotes proteins
T3199 510-515 PR_EXT:000003137 denotes furin
T3200 521-530 GO_EXT:0008233 denotes proteases
T3201 597-606 SO_EXT:sequence_truncation_process denotes truncated
T3202 615-621 PR_EXT:000003710 denotes ADAM11
T3203 622-629 CHEBI_PR_EXT:protein denotes protein
T3204 677-683 PR_EXT:000003710 denotes ADAM11
T3205 684-691 CHEBI_PR_EXT:protein denotes protein
T3206 706-713 SO_EXT:sequence_altered_entity denotes mutants
T3207 770-778 GO:0042571 denotes antibody
T3208 799-805 PR_EXT:000003710 denotes ADAM11
T3209 806-813 CHEBI_PR_EXT:protein denotes protein
T3210 875-882 SO_EXT:sequence_altered_entity denotes mutants
T3211 918-927 SO_EXT:wild_type_entity_or_quality denotes wild-type
T3212 938-944 PR_EXT:000003710 denotes ADAM11
T3213 945-952 CHEBI_PR_EXT:protein denotes protein

craft-sa-dev

Id Subject Object Predicate Lexical cue
T3287 383-385 VB denotes be
T3214 0-10 NN denotes Generation
T3215 11-13 IN denotes of
T3216 14-20 NN denotes ADAM11
T3217 21-30 JJ denotes deficient
T3218 20-21 HYPH denotes -
T3219 31-35 NNS denotes mice
T3220 35-144 sentence denotes Mice carrying a targeted mutation in their Adam11 gene were generated by homologous recombination (Fig. 1A).
T3221 36-40 NNS denotes Mice
T3222 96-105 VBN denotes generated
T3223 41-49 VBG denotes carrying
T3224 50-51 DT denotes a
T3225 61-69 NN denotes mutation
T3226 52-60 VBN denotes targeted
T3227 70-72 IN denotes in
T3228 73-78 PRP$ denotes their
T3229 86-90 NN denotes gene
T3230 79-85 NN denotes Adam11
T3231 91-95 VBD denotes were
T3232 106-108 IN denotes by
T3233 109-119 JJ denotes homologous
T3234 120-133 NN denotes recombination
T3235 134-135 -LRB- denotes (
T3236 140-142 NN denotes 1A
T3237 135-139 NN denotes Fig.
T3238 142-143 -RRB- denotes )
T3239 143-144 . denotes .
T3240 144-221 sentence denotes Correct targeting events were confirmed by Southern blot analysis (Fig. 1B).
T3241 145-152 JJ denotes Correct
T3242 163-169 NNS denotes events
T3243 153-162 NN denotes targeting
T3244 175-184 VBN denotes confirmed
T3245 170-174 VBD denotes were
T3246 185-187 IN denotes by
T3247 188-196 NNP denotes Southern
T3248 197-201 NN denotes blot
T3249 202-210 NN denotes analysis
T3250 211-212 -LRB- denotes (
T3251 217-219 NN denotes 1B
T3252 212-216 NN denotes Fig.
T3253 219-220 -RRB- denotes )
T3254 220-221 . denotes .
T3255 221-424 sentence denotes As a result of this procedure, since a termination codon was introduced in exon 5 in the pro-protein domain, only the truncated form of the ADAM11 protein would be synthesised from this targeted allele.
T3256 222-224 IN denotes As
T3257 386-397 VBN denotes synthesised
T3258 225-226 DT denotes a
T3259 227-233 NN denotes result
T3260 234-236 IN denotes of
T3261 237-241 DT denotes this
T3262 242-251 NN denotes procedure
T3263 251-253 , denotes ,
T3264 253-258 IN denotes since
T3265 283-293 VBN denotes introduced
T3266 259-260 DT denotes a
T3267 273-278 NN denotes codon
T3268 261-272 NN denotes termination
T3269 279-282 VBD denotes was
T3270 294-296 IN denotes in
T3271 297-301 NN denotes exon
T3272 302-303 CD denotes 5
T3273 304-306 IN denotes in
T3274 307-310 DT denotes the
T3275 323-329 NN denotes domain
T3276 311-322 JJ denotes pro-protein
T3277 329-331 , denotes ,
T3278 331-335 RB denotes only
T3279 350-354 NN denotes form
T3280 336-339 DT denotes the
T3281 340-349 VBN denotes truncated
T3282 355-357 IN denotes of
T3283 358-361 DT denotes the
T3284 369-376 NN denotes protein
T3285 362-368 NN denotes ADAM11
T3286 377-382 MD denotes would
T3288 398-402 IN denotes from
T3289 403-407 DT denotes this
T3290 417-423 NN denotes allele
T3291 408-416 VBN denotes targeted
T3292 423-424 . denotes .
T3293 424-658 sentence denotes Because pro-protein domains are always removed in mature functional ADAM-proteins by furin-like proteases and are thus thought to be non-functional, we concluded that this truncated form of ADAM11 protein would have no function [26].
T3294 425-432 IN denotes Because
T3295 464-471 VBN denotes removed
T3296 433-444 JJ denotes pro-protein
T3297 445-452 NNS denotes domains
T3298 453-456 VBP denotes are
T3299 457-463 RB denotes always
T3300 577-586 VBD denotes concluded
T3301 472-474 IN denotes in
T3302 475-481 JJ denotes mature
T3303 498-506 NN denotes proteins
T3304 482-492 JJ denotes functional
T3305 493-497 NN denotes ADAM
T3306 497-498 HYPH denotes -
T3307 507-509 IN denotes by
T3308 510-515 NN denotes furin
T3309 516-520 JJ denotes like
T3310 515-516 HYPH denotes -
T3311 521-530 NNS denotes proteases
T3312 531-534 CC denotes and
T3313 535-538 VBP denotes are
T3314 544-551 VBN denotes thought
T3315 539-543 RB denotes thus
T3316 552-554 TO denotes to
T3317 555-557 VB denotes be
T3318 558-572 JJ denotes non-functional
T3319 572-574 , denotes ,
T3320 574-576 PRP denotes we
T3321 587-591 IN denotes that
T3322 636-640 VB denotes have
T3323 592-596 DT denotes this
T3324 607-611 NN denotes form
T3325 597-606 VBN denotes truncated
T3326 612-614 IN denotes of
T3327 615-621 NN denotes ADAM11
T3328 622-629 NN denotes protein
T3329 630-635 MD denotes would
T3330 641-643 DT denotes no
T3331 644-652 NN denotes function
T3332 653-654 -LRB- denotes [
T3333 654-656 CD denotes 26
T3334 656-657 -RRB- denotes ]
T3335 657-658 . denotes .
T3336 658-824 sentence denotes Absence of mature ADAM11 protein in homozygous mutants was confirmed by Western blot analysis using a specific antibody that recognises the ADAM11 protein (Fig. 1C).
T3337 659-666 NN denotes Absence
T3338 718-727 VBN denotes confirmed
T3339 667-669 IN denotes of
T3340 670-676 JJ denotes mature
T3341 684-691 NN denotes protein
T3342 677-683 NN denotes ADAM11
T3343 692-694 IN denotes in
T3344 695-705 JJ denotes homozygous
T3345 706-713 NNS denotes mutants
T3346 714-717 VBD denotes was
T3347 728-730 IN denotes by
T3348 731-738 NNP denotes Western
T3349 739-743 NN denotes blot
T3350 744-752 NN denotes analysis
T3351 753-758 VBG denotes using
T3352 759-760 DT denotes a
T3353 770-778 NN denotes antibody
T3354 761-769 JJ denotes specific
T3355 779-783 WDT denotes that
T3356 784-794 VBZ denotes recognises
T3357 795-798 DT denotes the
T3358 806-813 NN denotes protein
T3359 799-805 NN denotes ADAM11
T3360 814-815 -LRB- denotes (
T3361 820-822 NN denotes 1C
T3362 815-819 NN denotes Fig.
T3363 822-823 -RRB- denotes )
T3364 823-824 . denotes .
T3365 824-953 sentence denotes Analysis by Western blot showed that heterozygous mutants produced approximately half of the wild-type levels of ADAM11 protein.
T3366 825-833 NN denotes Analysis
T3367 850-856 VBD denotes showed
T3368 834-836 IN denotes by
T3369 837-844 NNP denotes Western
T3370 845-849 NN denotes blot
T3371 857-861 IN denotes that
T3372 883-891 VBD denotes produced
T3373 862-874 JJ denotes heterozygous
T3374 875-882 NNS denotes mutants
T3375 892-905 RB denotes approximately
T3376 906-910 NN denotes half
T3377 911-913 IN denotes of
T3378 914-917 DT denotes the
T3379 928-934 NNS denotes levels
T3380 918-922 JJ denotes wild
T3381 923-927 NN denotes type
T3382 922-923 HYPH denotes -
T3383 935-937 IN denotes of
T3384 938-944 NN denotes ADAM11
T3385 945-952 NN denotes protein
T3386 952-953 . denotes .
R801 T3215 T3214 prep of,Generation
R802 T3216 T3217 npadvmod ADAM11,deficient
R803 T3217 T3219 amod deficient,mice
R804 T3218 T3217 punct -,deficient
R805 T3219 T3215 pobj mice,of
R806 T3221 T3222 nsubjpass Mice,generated
R807 T3223 T3221 acl carrying,Mice
R808 T3224 T3225 det a,mutation
R809 T3225 T3223 dobj mutation,carrying
R810 T3226 T3225 amod targeted,mutation
R811 T3227 T3223 prep in,carrying
R812 T3228 T3229 poss their,gene
R813 T3229 T3227 pobj gene,in
R814 T3230 T3229 compound Adam11,gene
R815 T3231 T3222 auxpass were,generated
R816 T3232 T3222 prep by,generated
R817 T3233 T3234 amod homologous,recombination
R818 T3234 T3232 pobj recombination,by
R819 T3235 T3236 punct (,1A
R820 T3236 T3222 parataxis 1A,generated
R821 T3237 T3236 compound Fig.,1A
R822 T3238 T3236 punct ),1A
R823 T3239 T3222 punct .,generated
R824 T3241 T3242 amod Correct,events
R825 T3242 T3244 nsubjpass events,confirmed
R826 T3243 T3242 compound targeting,events
R827 T3245 T3244 auxpass were,confirmed
R828 T3246 T3244 agent by,confirmed
R829 T3247 T3248 compound Southern,blot
R830 T3248 T3249 compound blot,analysis
R831 T3249 T3246 pobj analysis,by
R832 T3250 T3251 punct (,1B
R833 T3251 T3244 parataxis 1B,confirmed
R834 T3252 T3251 compound Fig.,1B
R835 T3253 T3251 punct ),1B
R836 T3254 T3244 punct .,confirmed
R837 T3256 T3257 prep As,synthesised
R838 T3258 T3259 det a,result
R839 T3259 T3256 pobj result,As
R840 T3260 T3259 prep of,result
R841 T3261 T3262 det this,procedure
R842 T3262 T3260 pobj procedure,of
R843 T3263 T3257 punct ", ",synthesised
R844 T3264 T3265 mark since,introduced
R846 T3266 T3267 det a,codon
R847 T3267 T3265 nsubjpass codon,introduced
R848 T3268 T3267 compound termination,codon
R849 T3269 T3265 auxpass was,introduced
R850 T3270 T3265 prep in,introduced
R851 T3271 T3270 pobj exon,in
R852 T3272 T3271 nummod 5,exon
R853 T3273 T3265 prep in,introduced
R854 T3274 T3275 det the,domain
R855 T3275 T3273 pobj domain,in
R856 T3276 T3275 amod pro-protein,domain
R857 T3277 T3257 punct ", ",synthesised
R858 T3278 T3279 advmod only,form
R859 T3279 T3257 nsubjpass form,synthesised
R860 T3280 T3279 det the,form
R861 T3281 T3279 amod truncated,form
R862 T3282 T3279 prep of,form
R863 T3283 T3284 det the,protein
R864 T3284 T3282 pobj protein,of
R865 T3285 T3284 compound ADAM11,protein
R866 T3286 T3257 aux would,synthesised
R867 T3287 T3257 auxpass be,synthesised
R868 T3288 T3257 prep from,synthesised
R869 T3289 T3290 det this,allele
R870 T3290 T3288 pobj allele,from
R871 T3291 T3290 amod targeted,allele
R872 T3292 T3257 punct .,synthesised
R873 T3294 T3295 mark Because,removed
R875 T3296 T3297 amod pro-protein,domains
R876 T3297 T3295 nsubjpass domains,removed
R877 T3298 T3295 auxpass are,removed
R878 T3299 T3295 advmod always,removed
R879 T3301 T3295 prep in,removed
R880 T3302 T3303 amod mature,proteins
R881 T3303 T3301 pobj proteins,in
R882 T3304 T3303 amod functional,proteins
R883 T3305 T3303 compound ADAM,proteins
R884 T3306 T3303 punct -,proteins
R885 T3307 T3295 agent by,removed
R886 T3308 T3309 npadvmod furin,like
R887 T3309 T3311 amod like,proteases
R888 T3310 T3309 punct -,like
R889 T3311 T3307 pobj proteases,by
R890 T3312 T3295 cc and,removed
R891 T3313 T3314 auxpass are,thought
R892 T3314 T3295 conj thought,removed
R893 T3315 T3314 advmod thus,thought
R894 T3316 T3317 aux to,be
R895 T3317 T3314 xcomp be,thought
R896 T3318 T3317 acomp non-functional,be
R897 T3319 T3300 punct ", ",concluded
R898 T3320 T3300 nsubj we,concluded
R899 T3321 T3322 mark that,have
R900 T3322 T3300 ccomp have,concluded
R901 T3323 T3324 det this,form
R902 T3324 T3322 nsubj form,have
R903 T3325 T3324 amod truncated,form
R904 T3326 T3324 prep of,form
R905 T3327 T3328 compound ADAM11,protein
R906 T3328 T3326 pobj protein,of
R907 T3329 T3322 aux would,have
R908 T3330 T3331 det no,function
R909 T3331 T3322 dobj function,have
R910 T3332 T3333 punct [,26
R911 T3333 T3322 parataxis 26,have
R912 T3334 T3333 punct ],26
R913 T3335 T3300 punct .,concluded
R914 T3337 T3338 nsubjpass Absence,confirmed
R915 T3339 T3337 prep of,Absence
R916 T3340 T3341 amod mature,protein
R917 T3341 T3339 pobj protein,of
R918 T3342 T3341 compound ADAM11,protein
R919 T3343 T3337 prep in,Absence
R920 T3344 T3345 amod homozygous,mutants
R921 T3345 T3343 pobj mutants,in
R922 T3346 T3338 auxpass was,confirmed
R923 T3347 T3338 prep by,confirmed
R924 T3348 T3349 compound Western,blot
R925 T3349 T3350 compound blot,analysis
R926 T3350 T3347 pobj analysis,by
R927 T3351 T3350 acl using,analysis
R928 T3352 T3353 det a,antibody
R929 T3353 T3351 dobj antibody,using
R930 T3354 T3353 amod specific,antibody
R931 T3355 T3356 dep that,recognises
R932 T3356 T3353 relcl recognises,antibody
R933 T3357 T3358 det the,protein
R934 T3358 T3356 dobj protein,recognises
R935 T3359 T3358 compound ADAM11,protein
R936 T3360 T3361 punct (,1C
R937 T3361 T3338 parataxis 1C,confirmed
R938 T3362 T3361 compound Fig.,1C
R939 T3363 T3361 punct ),1C
R940 T3364 T3338 punct .,confirmed
R941 T3366 T3367 nsubj Analysis,showed
R942 T3368 T3366 prep by,Analysis
R943 T3369 T3370 compound Western,blot
R944 T3370 T3368 pobj blot,by
R945 T3371 T3372 mark that,produced
R946 T3372 T3367 ccomp produced,showed
R947 T3373 T3374 amod heterozygous,mutants
R948 T3374 T3372 nsubj mutants,produced
R949 T3375 T3376 advmod approximately,half
R950 T3376 T3372 dobj half,produced
R951 T3377 T3376 prep of,half
R952 T3378 T3379 det the,levels
R953 T3379 T3377 pobj levels,of
R954 T3380 T3381 amod wild,type
R955 T3381 T3379 compound type,levels
R956 T3382 T3381 punct -,type
R957 T3383 T3379 prep of,levels
R958 T3384 T3385 compound ADAM11,protein
R959 T3385 T3383 pobj protein,of
R960 T3386 T3367 punct .,showed
R845 T3265 T3257 advcl introduced,synthesised
R874 T3295 T3300 advcl removed,concluded