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PMC:1420314 / 2886-3799 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T2014 33-39 PR:000003710 denotes ADAM11
T2015 41-47 PR:000003718 denotes ADAM22
T2016 52-58 PR:000003719 denotes ADAM23
T2017 59-64 SO:0000704 denotes genes
T2018 86-96 GO:0010467 denotes expression
T2019 104-109 NCBITaxon:9606 denotes human
T2020 114-120 NCBITaxon:39107 denotes murine
T2021 121-136 UBERON:0001016 denotes nervous systems
T2022 313-327 GO:0016477 denotes cell migration
T2024 313-317,329-344 GO:0030154 denotes cell differentiation
T2025 361-369 GO:0045202 denotes synaptic
T2026 370-380 GO:0065007 denotes regulation
T2027 406-418 GO:0009986 denotes cell-surface
T2028 431-444 GO:0005622 denotes intracellular
T2029 431-455 GO:0035556 denotes intracellular signalling
T2030 445-465 CHEBI:62488 denotes signalling molecules
T2031 521-526 GO:0016265 denotes death
T2032 583-608 UBERON:0000010 denotes peripheral nervous system
T2033 612-618 PR:000003718 denotes Adam22
T2034 631-635 NCBITaxon:10088 denotes mice
T2035 686-692 PR:000003719 denotes Adam23
T2036 693-697 SO:0000704 denotes gene
T2037 705-710 NCBITaxon:10088 denotes mouse
T2038 732-737 GO:0016265 denotes death
T2039 846-851 UBERON:0000955 denotes brain
T2040 880-886 PR:000003718 denotes Adam22
T2041 896-902 PR:000003719 denotes Adam23
T2042 908-912 NCBITaxon:10088 denotes mice

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T2132 33-39 PR_EXT:000003710 denotes ADAM11
T2133 41-47 PR_EXT:000003718 denotes ADAM22
T2134 52-58 PR_EXT:000003719 denotes ADAM23
T2135 59-64 SO_EXT:0000704 denotes genes
T2136 86-96 GO:0010467 denotes expression
T2137 104-109 NCBITaxon:9606 denotes human
T2138 114-120 NCBITaxon:39107 denotes murine
T2139 121-136 UBERON:0001016 denotes nervous systems
T2140 165-174 GO_MOP_EXT:catalysis denotes catalytic
T2141 175-180 SO_EXT:sequence_or_structure_motif denotes motif
T2142 198-215 GO_EXT:0008237 denotes metalloproteinase
T2143 255-264 GO_EXT:0008233 denotes proteases
T2144 313-317 CL_GO_EXT:cell denotes cell
T2145 313-327 GO:0016477 denotes cell migration
T2147 313-317,329-344 GO:0030154 denotes cell differentiation
T2148 361-369 GO:0045202 denotes synaptic
T2149 370-380 GO:0065007 denotes regulation
T2150 384-391 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2151 395-404 GO_PR_EXT:integrin denotes integrins
T2152 406-410 CL_GO_EXT:cell denotes cell
T2153 406-418 GO:0009986 denotes cell-surface
T2154 419-427 CHEBI_PR_EXT:protein denotes proteins
T2155 431-444 GO:0005622 denotes intracellular
T2156 431-455 GO:0035556 denotes intracellular signalling
T2157 436-444 CL_GO_EXT:cell denotes cellular
T2158 445-465 CHEBI_EXT:62488 denotes signalling molecules
T2159 521-526 GO:0016265 denotes death
T2160 564-575 GO_EXT:myelin_assembly_or_myelination denotes myelination
T2161 583-608 UBERON:0000010 denotes peripheral nervous system
T2162 612-618 PR_EXT:000003718 denotes Adam22
T2163 619-623 SO_EXT:sequence_nullness denotes null
T2164 624-630 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2165 631-635 NCBITaxon:10088 denotes mice
T2166 686-692 PR_EXT:000003719 denotes Adam23
T2167 693-697 SO_EXT:0000704 denotes gene
T2168 705-710 NCBITaxon:10088 denotes mouse
T2169 732-737 GO:0016265 denotes death
T2170 846-851 UBERON:0000955 denotes brain
T2171 880-886 PR_EXT:000003718 denotes Adam22
T2172 887-891 SO_EXT:sequence_nullness denotes null
T2173 896-902 PR_EXT:000003719 denotes Adam23
T2174 903-907 SO_EXT:sequence_nullness denotes null
T2175 908-912 NCBITaxon:10088 denotes mice

craft-sa-dev

Id Subject Object Predicate Lexical cue
T2515 0-2 PRP denotes We
T2516 8-16 VBN denotes reported
T2517 3-7 VBP denotes have
T2518 17-20 DT denotes the
T2519 21-29 NNS denotes findings
T2520 30-32 IN denotes of
T2521 33-39 NN denotes ADAM11
T2522 59-64 NNS denotes genes
T2523 39-41 , denotes ,
T2524 41-47 NN denotes ADAM22
T2525 48-51 CC denotes and
T2526 52-58 NN denotes ADAM23
T2527 65-68 CC denotes and
T2528 69-74 PRP$ denotes their
T2529 86-96 NN denotes expression
T2530 75-85 VBN denotes restricted
T2531 97-99 IN denotes in
T2532 100-103 DT denotes the
T2533 129-136 NNS denotes systems
T2534 104-109 JJ denotes human
T2535 110-113 CC denotes and
T2536 114-120 JJ denotes murine
T2537 121-128 JJ denotes nervous
T2538 137-138 -LRB- denotes [
T2539 141-143 CD denotes 19
T2540 138-140 CD denotes 18
T2541 140-141 , denotes ,
T2542 143-144 -RRB- denotes ]
T2543 144-145 . denotes .
T2544 145-265 sentence denotes These ADAMs lack a catalytic motif critical for the metalloproteinase activity, suggesting that they are not proteases.
T2545 146-151 DT denotes These
T2546 152-157 NNS denotes ADAMs
T2547 158-162 VBP denotes lack
T2548 163-164 DT denotes a
T2549 175-180 NN denotes motif
T2550 165-174 JJ denotes catalytic
T2551 181-189 JJ denotes critical
T2552 190-193 IN denotes for
T2553 194-197 DT denotes the
T2554 216-224 NN denotes activity
T2555 198-215 NN denotes metalloproteinase
T2556 224-226 , denotes ,
T2557 226-236 VBG denotes suggesting
T2558 237-241 IN denotes that
T2559 247-250 VBP denotes are
T2560 242-246 PRP denotes they
T2561 251-254 RB denotes not
T2562 255-264 NNS denotes proteases
T2563 264-265 . denotes .
T2564 265-474 sentence denotes We assume that these ADAMs might contribute to cell migration, differentiation and survival or synaptic regulation by binding to integrins, cell-surface proteins or intracellular signalling molecules [20,21].
T2565 266-268 PRP denotes We
T2566 269-275 VBP denotes assume
T2567 276-280 IN denotes that
T2568 299-309 VB denotes contribute
T2569 281-286 DT denotes these
T2570 287-292 NNS denotes ADAMs
T2571 293-298 MD denotes might
T2572 310-312 IN denotes to
T2573 313-317 NN denotes cell
T2574 318-327 NN denotes migration
T2575 327-329 , denotes ,
T2576 329-344 NN denotes differentiation
T2577 345-348 CC denotes and
T2578 349-357 NN denotes survival
T2579 358-360 CC denotes or
T2580 361-369 JJ denotes synaptic
T2581 370-380 NN denotes regulation
T2582 381-383 IN denotes by
T2583 384-391 VBG denotes binding
T2584 392-394 IN denotes to
T2585 395-404 NNS denotes integrins
T2586 404-406 , denotes ,
T2587 406-410 NN denotes cell
T2588 411-418 NN denotes surface
T2589 410-411 HYPH denotes -
T2590 419-427 NN denotes proteins
T2591 428-430 CC denotes or
T2592 431-444 JJ denotes intracellular
T2593 456-465 NNS denotes molecules
T2594 445-455 NN denotes signalling
T2595 466-467 -LRB- denotes [
T2596 470-472 CD denotes 21
T2597 467-469 CD denotes 20
T2598 469-470 , denotes ,
T2599 472-473 -RRB- denotes ]
T2600 473-474 . denotes .
T2601 474-641 sentence denotes We have reported severe ataxia, seizures, and death before weaning, accompanied with hypomyelination of the peripheral nervous system in Adam22-null mutant mice [22].
T2602 475-477 PRP denotes We
T2603 483-491 VBN denotes reported
T2604 478-482 VBP denotes have
T2605 492-498 JJ denotes severe
T2606 499-505 NN denotes ataxia
T2607 505-507 , denotes ,
T2608 507-515 NNS denotes seizures
T2609 515-517 , denotes ,
T2610 517-520 CC denotes and
T2611 521-526 NN denotes death
T2612 527-533 IN denotes before
T2613 534-541 NN denotes weaning
T2614 541-543 , denotes ,
T2615 543-554 VBN denotes accompanied
T2616 555-559 IN denotes with
T2617 560-575 NN denotes hypomyelination
T2618 576-578 IN denotes of
T2619 579-582 DT denotes the
T2620 602-608 NN denotes system
T2621 583-593 JJ denotes peripheral
T2622 594-601 JJ denotes nervous
T2623 609-611 IN denotes in
T2624 612-618 NN denotes Adam22
T2625 619-623 JJ denotes null
T2626 618-619 HYPH denotes -
T2627 631-635 NNS denotes mice
T2628 624-630 NN denotes mutant
T2629 636-637 -LRB- denotes [
T2630 637-639 CD denotes 22
T2631 639-640 -RRB- denotes ]
T2632 640-641 . denotes .
T2633 641-777 sentence denotes It has been reported that the disruption of Adam23 gene in the mouse results in premature death associated with ataxia and tremor [23].
T2634 642-644 PRP denotes It
T2635 654-662 VBN denotes reported
T2636 645-648 VBZ denotes has
T2637 649-653 VBN denotes been
T2638 663-667 IN denotes that
T2639 711-718 VBZ denotes results
T2640 668-671 DT denotes the
T2641 672-682 NN denotes disruption
T2642 683-685 IN denotes of
T2643 686-692 NN denotes Adam23
T2644 693-697 NN denotes gene
T2645 698-700 IN denotes in
T2646 701-704 DT denotes the
T2647 705-710 NN denotes mouse
T2648 719-721 IN denotes in
T2649 722-731 JJ denotes premature
T2650 732-737 NN denotes death
T2651 738-748 VBN denotes associated
T2652 749-753 IN denotes with
T2653 754-760 NN denotes ataxia
T2654 761-764 CC denotes and
T2655 765-771 NN denotes tremor
T2656 772-773 -LRB- denotes [
T2657 773-775 CD denotes 23
T2658 775-776 -RRB- denotes ]
T2659 776-777 . denotes .
T2660 777-913 sentence denotes Is spite of such extreme phenotypes, no histological defects in the brain has been observed in either Adam22-null nor Adam23-null mice.
T2661 778-780 IN denotes Is
T2662 861-869 VBN denotes observed
T2663 781-786 NN denotes spite
T2664 787-789 IN denotes of
T2665 790-794 JJ denotes such
T2666 803-813 NNS denotes phenotypes
T2667 795-802 JJ denotes extreme
T2668 813-815 , denotes ,
T2669 815-817 DT denotes no
T2670 831-838 NNS denotes defects
T2671 818-830 JJ denotes histological
T2672 839-841 IN denotes in
T2673 842-845 DT denotes the
T2674 846-851 NN denotes brain
T2675 852-855 VBZ denotes has
T2676 856-860 VBN denotes been
T2677 870-872 IN denotes in
T2678 873-879 CC denotes either
T2679 908-912 NNS denotes mice
T2680 880-886 NN denotes Adam22
T2681 887-891 JJ denotes null
T2682 886-887 HYPH denotes -
T2683 892-895 CC denotes nor
T2684 896-902 NN denotes Adam23
T2685 903-907 JJ denotes null
T2686 902-903 HYPH denotes -
T2687 912-913 . denotes .
R505 T2515 T2516 nsubj We,reported
R506 T2517 T2516 aux have,reported
R507 T2518 T2519 det the,findings
R508 T2519 T2516 dobj findings,reported
R509 T2520 T2519 prep of,findings
R510 T2521 T2522 nmod ADAM11,genes
R512 T2523 T2521 punct ", ",ADAM11
R513 T2524 T2521 conj ADAM22,ADAM11
R514 T2525 T2524 cc and,ADAM22
R515 T2526 T2524 conj ADAM23,ADAM22
R516 T2527 T2522 cc and,genes
R517 T2528 T2529 poss their,expression
R518 T2529 T2522 conj expression,genes
R519 T2636 T2635 aux has,reported
R520 T2530 T2529 amod restricted,expression
R521 T2637 T2635 auxpass been,reported
R522 T2531 T2529 prep in,expression
R523 T2638 T2639 mark that,results
R524 T2532 T2533 det the,systems
R525 T2639 T2635 ccomp results,reported
R526 T2533 T2531 pobj systems,in
R527 T2640 T2641 det the,disruption
R528 T2534 T2533 amod human,systems
R529 T2535 T2534 cc and,human
R530 T2641 T2639 nsubj disruption,results
R531 T2536 T2534 conj murine,human
R532 T2537 T2533 amod nervous,systems
R533 T2538 T2539 punct [,19
R534 T2539 T2516 parataxis 19,reported
R535 T2540 T2539 nummod 18,19
R536 T2541 T2539 punct ",",19
R537 T2642 T2641 prep of,disruption
R538 T2542 T2539 punct ],19
R539 T2543 T2516 punct .,reported
R540 T2643 T2644 compound Adam23,gene
R541 T2545 T2546 det These,ADAMs
R542 T2644 T2642 pobj gene,of
R543 T2645 T2641 prep in,disruption
R544 T2546 T2547 nsubj ADAMs,lack
R545 T2646 T2647 det the,mouse
R546 T2548 T2549 det a,motif
R547 T2549 T2547 dobj motif,lack
R548 T2647 T2645 pobj mouse,in
R549 T2550 T2549 amod catalytic,motif
R550 T2551 T2549 amod critical,motif
R551 T2648 T2639 prep in,results
R552 T2552 T2551 prep for,critical
R553 T2553 T2554 det the,activity
R554 T2554 T2552 pobj activity,for
R555 T2649 T2650 amod premature,death
R556 T2555 T2554 compound metalloproteinase,activity
R557 T2556 T2547 punct ", ",lack
R558 T2557 T2547 advcl suggesting,lack
R559 T2650 T2648 pobj death,in
R560 T2558 T2559 mark that,are
R561 T2559 T2557 ccomp are,suggesting
R562 T2560 T2559 nsubj they,are
R563 T2651 T2650 acl associated,death
R564 T2561 T2559 neg not,are
R565 T2652 T2651 prep with,associated
R566 T2562 T2559 attr proteases,are
R567 T2563 T2547 punct .,lack
R568 T2565 T2566 nsubj We,assume
R569 T2653 T2652 pobj ataxia,with
R570 T2567 T2568 mark that,contribute
R571 T2654 T2653 cc and,ataxia
R572 T2568 T2566 ccomp contribute,assume
R573 T2569 T2570 det these,ADAMs
R574 T2570 T2568 nsubj ADAMs,contribute
R575 T2655 T2653 conj tremor,ataxia
R576 T2571 T2568 aux might,contribute
R577 T2572 T2568 prep to,contribute
R578 T2573 T2574 compound cell,migration
R579 T2574 T2572 pobj migration,to
R580 T2656 T2657 punct [,23
R581 T2575 T2574 punct ", ",migration
R582 T2576 T2574 conj differentiation,migration
R583 T2657 T2635 parataxis 23,reported
R584 T2577 T2576 cc and,differentiation
R585 T2578 T2576 conj survival,differentiation
R586 T2579 T2574 cc or,migration
R587 T2580 T2581 amod synaptic,regulation
R588 T2581 T2574 conj regulation,migration
R589 T2582 T2568 prep by,contribute
R590 T2583 T2582 pcomp binding,by
R591 T2658 T2657 punct ],23
R592 T2584 T2583 prep to,binding
R593 T2585 T2584 pobj integrins,to
R594 T2586 T2585 punct ", ",integrins
R595 T2659 T2635 punct .,reported
R596 T2587 T2588 compound cell,surface
R597 T2588 T2590 compound surface,proteins
R598 T2589 T2588 punct -,surface
R599 T2661 T2662 prep Is,observed
R600 T2590 T2585 conj proteins,integrins
R601 T2591 T2590 cc or,proteins
R602 T2592 T2593 amod intracellular,molecules
R603 T2593 T2590 conj molecules,proteins
R604 T2663 T2661 pobj spite,Is
R605 T2594 T2593 compound signalling,molecules
R606 T2595 T2596 punct [,21
R607 T2596 T2568 parataxis 21,contribute
R608 T2597 T2596 nummod 20,21
R609 T2598 T2596 punct ",",21
R610 T2664 T2663 prep of,spite
R611 T2599 T2596 punct ],21
R612 T2600 T2566 punct .,assume
R613 T2665 T2666 amod such,phenotypes
R614 T2602 T2603 nsubj We,reported
R615 T2666 T2664 pobj phenotypes,of
R616 T2604 T2603 aux have,reported
R617 T2667 T2666 amod extreme,phenotypes
R618 T2605 T2606 amod severe,ataxia
R619 T2606 T2603 dobj ataxia,reported
R620 T2607 T2606 punct ", ",ataxia
R621 T2668 T2662 punct ", ",observed
R622 T2608 T2606 conj seizures,ataxia
R623 T2609 T2608 punct ", ",seizures
R624 T2610 T2608 cc and,seizures
R625 T2669 T2670 det no,defects
R626 T2611 T2608 conj death,seizures
R627 T2612 T2611 prep before,death
R628 T2613 T2612 pobj weaning,before
R629 T2670 T2662 nsubjpass defects,observed
R630 T2614 T2606 punct ", ",ataxia
R631 T2615 T2606 acl accompanied,ataxia
R632 T2671 T2670 amod histological,defects
R633 T2616 T2615 prep with,accompanied
R634 T2617 T2616 pobj hypomyelination,with
R635 T2618 T2617 prep of,hypomyelination
R636 T2672 T2670 prep in,defects
R637 T2619 T2620 det the,system
R638 T2673 T2674 det the,brain
R639 T2620 T2618 pobj system,of
R640 T2621 T2620 amod peripheral,system
R641 T2622 T2620 amod nervous,system
R642 T2623 T2603 prep in,reported
R643 T2624 T2625 npadvmod Adam22,null
R644 T2674 T2672 pobj brain,in
R645 T2625 T2627 amod null,mice
R646 T2626 T2625 punct -,null
R647 T2627 T2623 pobj mice,in
R648 T2675 T2662 aux has,observed
R649 T2628 T2627 compound mutant,mice
R650 T2629 T2630 punct [,22
R651 T2630 T2603 parataxis 22,reported
R652 T2676 T2662 auxpass been,observed
R653 T2631 T2630 punct ],22
R654 T2632 T2603 punct .,reported
R655 T2677 T2662 prep in,observed
R656 T2634 T2635 nsubjpass It,reported
R657 T2678 T2679 preconj either,mice
R658 T2679 T2677 pobj mice,in
R659 T2680 T2681 npadvmod Adam22,null
R660 T2681 T2679 amod null,mice
R661 T2682 T2681 punct -,null
R662 T2683 T2681 cc nor,null
R665 T2684 T2685 npadvmod Adam23,null
R668 T2685 T2681 conj null,null
R673 T2686 T2685 punct -,null
R676 T2687 T2662 punct .,observed
R511 T2522 T2520 pobj genes,of