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PMC:1420314 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T469 20-28 GO:0007612 denotes learning
T470 55-61 PR:000003710 denotes ADAM11
T471 72-76 NCBITaxon:10088 denotes mice
T472 98-104 PR:000003710 denotes ADAM11
T473 129-133 SO:0000704 denotes gene
T474 155-164 GO:0010467 denotes expressed
T475 172-186 UBERON:0001016 denotes nervous system
T476 220-228 CHEBI:36357 denotes molecule
T477 298-304 GO:0031012 denotes matrix
T478 363-369 PR:000003710 denotes ADAM11
T479 384-390 PR:000003710 denotes ADAM11
T480 401-405 NCBITaxon:10088 denotes mice
T481 418-422 SO:0000704 denotes gene
T482 443-449 PR:000003710 denotes ADAM11
T483 460-464 NCBITaxon:10088 denotes mice
T484 569-574 UBERON:0000955 denotes brain
T485 578-589 UBERON:0002240 denotes spinal cord
T486 599-605 PR:000003710 denotes ADAM11
T487 616-625 GO:0010467 denotes expressed
T488 649-659 UBERON:0002037 denotes cerebellum
T489 678-684 PR:000003710 denotes ADAM11
T490 692-696 NCBITaxon:10088 denotes mice
T491 701-709 GO:0007612 denotes learning
T492 716-722 GO:0007601 denotes visual
T493 734-739 CHEBI:15377 denotes water
T494 838-844 GO:0007601 denotes visual
T495 845-850 CHEBI:15377 denotes water
T496 896-901 CHEBI:15377 denotes water
T497 952-958 PR:000003710 denotes ADAM11
T498 969-973 NCBITaxon:10088 denotes mice
T499 1013-1019 PR:000003710 denotes ADAM11
T500 1045-1059 GO:0016477 denotes cell migration
T501 1045-1049 _FRAGMENT denotes cell
T502 1064-1079 GO:0030154 denotes differentiation
T503 1112-1120 GO:0007612 denotes learning
T504 1151-1157 PR:000003710 denotes ADAM11
T505 1231-1239 CHEBI:36357 denotes molecule
T506 1247-1254 GO:0045202 denotes synapse
T507 1284-1292 GO:0045202 denotes synaptic
T508 1293-1303 GO:0065007 denotes regulation
T1984 1410-1418 GO:0016020 denotes membrane
T1985 1434-1440 SO:0000417 denotes domain
T1986 1486-1492 SO:0000417 denotes domain
T1987 1516-1522 SO:0000417 denotes domain
T1988 1692-1701 CHEBI:36357 denotes molecules
T1989 1716-1720 SO:0000704 denotes gene
T1990 1743-1747 NCBITaxon:10088 denotes mice
T1991 1811-1817 PR:000001278 denotes ADAM10
T1992 1819-1825 PR:000001279 denotes ADAM17
T1993 1830-1836 PR:000003714 denotes ADAM19
T1994 1970-1975 PR:000001280 denotes ADAM8
T1995 1977-1982 PR:000003725 denotes ADAM9
T1996 1984-1990 PR:000003711 denotes ADAM12
T1997 1995-2001 PR:000003712 denotes ADAM15
T1998 2024-2037 GO:0009790 denotes embryogenesis
T1999 2188-2197 CHEBI:36357 denotes molecules
T2000 2361-2375 GO:0016477 denotes cell migration
T2001 2379-2385 UBERON:0000479 denotes tissue
T2002 2386-2399 CL:0000010 denotes culture cells
T2003 2407-2417 GO:0065007 denotes controlled
T2004 2445-2455 NCBITaxon:6239 denotes C. elegans
T2005 2457-2463 PR:000003714 denotes unc-71
T2006 2464-2468 SO:0000704 denotes gene
T2007 2538-2552 GO:0016477 denotes cell migration
T2008 2610-2619 NCBITaxon:40674 denotes mammalian
T2009 2670-2677 SO:0000704 denotes Genetic
T2010 2698-2702 NCBITaxon:10088 denotes mice
T2011 2724-2729 PR:000003715 denotes Adam2
T2012 2787-2798 CL:0000019 denotes spermatozoa
T2013 2804-2807 CL:0000025 denotes egg
T2014 2919-2925 PR:000003710 denotes ADAM11
T2015 2927-2933 PR:000003718 denotes ADAM22
T2016 2938-2944 PR:000003719 denotes ADAM23
T2017 2945-2950 SO:0000704 denotes genes
T2018 2972-2982 GO:0010467 denotes expression
T2019 2990-2995 NCBITaxon:9606 denotes human
T2020 3000-3006 NCBITaxon:39107 denotes murine
T2021 3007-3022 UBERON:0001016 denotes nervous systems
T2022 3199-3213 GO:0016477 denotes cell migration
T2023 3199-3203 _FRAGMENT denotes cell
T2024 3215-3230 GO:0030154 denotes differentiation
T2025 3247-3255 GO:0045202 denotes synaptic
T2026 3256-3266 GO:0065007 denotes regulation
T2027 3292-3304 GO:0009986 denotes cell-surface
T2028 3317-3330 GO:0005622 denotes intracellular
T2029 3317-3341 GO:0035556 denotes intracellular signalling
T2030 3331-3351 CHEBI:62488 denotes signalling molecules
T2031 3407-3412 GO:0016265 denotes death
T2032 3469-3494 UBERON:0000010 denotes peripheral nervous system
T2033 3498-3504 PR:000003718 denotes Adam22
T2034 3517-3521 NCBITaxon:10088 denotes mice
T2035 3572-3578 PR:000003719 denotes Adam23
T2036 3579-3583 SO:0000704 denotes gene
T2037 3591-3596 NCBITaxon:10088 denotes mouse
T2038 3618-3623 GO:0016265 denotes death
T2039 3732-3737 UBERON:0000955 denotes brain
T2040 3766-3772 PR:000003718 denotes Adam22
T2041 3782-3788 PR:000003719 denotes Adam23
T2042 3794-3798 NCBITaxon:10088 denotes mice
T2043 3800-3806 PR:000003710 denotes ADAM11
T2044 3822-3829 SO:0000854 denotes paralog
T2045 3833-3839 PR:000003718 denotes ADAM22
T2046 3844-3850 PR:000003719 denotes ADAM23
T2047 3860-3869 SO:0000855 denotes orthologs
T2048 3889-3900 NCBITaxon:7742 denotes vertebrates
T2049 3958-3965 NCBITaxon:8353 denotes Xenopus
T2050 3966-3972 PR:000003710 denotes ADAM11
T2051 3973-3981 SO:0000855 denotes ortholog
T2052 3999-4009 GO:0010467 denotes expression
T2053 4078-4092 GO:0016477 denotes cell migration
T2054 4168-4181 GO:0097617 denotes hybridisation
T2055 4199-4205 NCBITaxon:39107 denotes murine
T2056 4206-4212 PR:000003710 denotes Adam11
T2057 4213-4217 SO:0000704 denotes gene
T2058 4221-4230 GO:0010467 denotes expressed
T2059 4258-4263 UBERON:0007023 denotes adult
T2060 4264-4278 UBERON:0001016 denotes nervous system
T2061 4330-4336 PR:000003710 denotes ADAM11
T2062 4395-4409 UBERON:0001016 denotes nervous system
T2063 4417-4423 PR:000003718 denotes ADAM22
T2064 4428-4434 PR:000003719 denotes ADAM23
T2065 4480-4486 PR:000003710 denotes ADAM11
T2066 4514-4520 PR:000003710 denotes Adam11
T2067 4521-4525 SO:0000704 denotes gene
T2068 4535-4539 NCBITaxon:10088 denotes mice
T3160 4565-4571 PR:000003710 denotes ADAM11
T3161 4582-4586 NCBITaxon:10088 denotes mice
T3162 4587-4591 NCBITaxon:10088 denotes Mice
T3163 4630-4636 PR:000003710 denotes Adam11
T3164 4637-4641 SO:0000704 denotes gene
T3165 4812-4829 SO:0000319 denotes termination codon
T3166 4848-4852 SO:0000147 denotes exon
T3167 4862-4873 SO:0001062 denotes pro-protein
T3168 4874-4880 SO:0000417 denotes domain
T3169 4913-4919 PR:000003710 denotes ADAM11
T3170 4968-4974 SO:0001023 denotes allele
T3171 4984-4995 SO:0001062 denotes pro-protein
T3172 4996-5003 SO:0000417 denotes domains
T3173 5061-5066 PR:000003137 denotes furin
T3174 5166-5172 PR:000003710 denotes ADAM11
T3175 5228-5234 PR:000003710 denotes ADAM11
T3176 5321-5329 GO:0042571 denotes antibody
T3177 5350-5356 PR:000003710 denotes ADAM11
T3178 5489-5495 PR:000003710 denotes ADAM11
T3891 5506-5512 PR:000003710 denotes ADAM11
T3892 5523-5527 NCBITaxon:10088 denotes mice
T3893 5557-5563 GO:0007618 denotes Mating
T3894 5567-5571 NCBITaxon:10088 denotes mice
T3895 5593-5599 PR:000003710 denotes ADAM11
T3896 5786-5792 PR:000003710 denotes ADAM11
T3897 5808-5812 NCBITaxon:10088 denotes mice
T3898 5906-5916 UBERON:0001062 denotes anatomical
T3899 5950-5956 PR:000003710 denotes ADAM11
T3900 5967-5971 NCBITaxon:10088 denotes mice
T3901 6025-6031 PR:000003710 denotes Adam11
T3902 6032-6036 SO:0000704 denotes gene
T3903 6116-6120 NCBITaxon:10088 denotes mice
T3904 6163-6167 NCBITaxon:10088 denotes mice
T3905 6256-6265 GO:0040011 denotes locomotor
T3906 6344-6354 UBERON:0001062 denotes anatomical
T3907 6395-6406 UBERON:0002240 denotes spinal cord
T3908 6408-6413 UBERON:0000948 denotes heart
T3909 6415-6419 UBERON:0002048 denotes lung
T3910 6421-6426 UBERON:0002107 denotes liver
T3911 6428-6434 UBERON:0002113 denotes kidney
T3912 6436-6442 UBERON:0002106 denotes spleen
T3913 6444-6450 UBERON:0000473 denotes testis
T3914 6454-6459 UBERON:0000992 denotes ovary
T3915 6482-6487 UBERON:0000955 denotes brain
T3916 6497-6501 NCBITaxon:10088 denotes mice
T3917 6543-6553 UBERON:0002037 denotes cerebellum
T3918 6626-6630 NCBITaxon:10088 denotes mice
T3919 6652-6658 PR:000003710 denotes Adam11
T3920 6676-6685 GO:0010467 denotes expressed
T3921 6709-6719 UBERON:0002037 denotes cerebellum
T3922 6748-6758 UBERON:0002037 denotes cerebellum
T5113 6800-6808 GO:0007612 denotes learning
T5114 6812-6818 PR:000003710 denotes ADAM11
T5115 6829-6833 NCBITaxon:10088 denotes mice
T5116 6860-6866 PR:000003710 denotes ADAM11
T5117 6911-6919 GO:0007612 denotes learning
T5118 6931-6937 PR:000003710 denotes ADAM11
T5119 6948-6952 NCBITaxon:10088 denotes mice
T5120 6970-6975 CHEBI:15377 denotes Water
T5121 6999-7003 NCBITaxon:10088 denotes mice
T5122 7053-7057 NCBITaxon:10088 denotes mice
T5123 7111-7116 CHEBI:15377 denotes water
T5124 7118-7124 PR:000003710 denotes Adam11
T5125 7131-7135 NCBITaxon:10088 denotes mice
T5126 7234-7238 NCBITaxon:10088 denotes mice
T5127 7301-7305 NCBITaxon:10088 denotes mice
T5128 7402-7406 NCBITaxon:10088 denotes mice
T5129 7420-7425 GO:0007612 denotes learn
T5130 7526-7530 NCBITaxon:10088 denotes mice
T5131 7591-7595 NCBITaxon:10088 denotes mice
T5132 7742-7746 NCBITaxon:10088 denotes mice
T5133 7763-7767 GO:0036268 denotes swim
T5134 7876-7880 NCBITaxon:10088 denotes mice
T5135 7892-7898 PR:000003710 denotes Adam11
T5136 7905-7909 NCBITaxon:10088 denotes mice
T5137 8031-8035 NCBITaxon:10088 denotes mice
T5138 8080-8088 GO:0007612 denotes learning
T5139 8109-8113 NCBITaxon:10088 denotes mice
T5140 8119-8127 GO:0036268 denotes swimming
T5141 8163-8167 NCBITaxon:10088 denotes mice
T5142 8273-8277 NCBITaxon:10088 denotes mice
T5143 8478-8482 NCBITaxon:10088 denotes mice
T5144 8483-8488 GO:0007612 denotes learn
T5145 8548-8552 NCBITaxon:10088 denotes mice
T5146 8594-8598 NCBITaxon:10088 denotes mice
T5147 8671-8676 CHEBI:15377 denotes water
T6552 8707-8713 PR:000003710 denotes ADAM11
T6553 8724-8728 NCBITaxon:10088 denotes mice
T6554 8755-8761 PR:000003710 denotes ADAM11
T6555 8769-8779 UBERON:0002037 denotes cerebellum
T6556 8815-8821 PR:000003710 denotes ADAM11
T6557 8832-8836 NCBITaxon:10088 denotes mice
T6558 8933-8937 NCBITaxon:10088 denotes mice
T6559 9000-9004 NCBITaxon:10088 denotes mice
T6560 9115-9119 NCBITaxon:10088 denotes mice
T6561 9257-9261 NCBITaxon:10088 denotes mice
T6562 9409-9413 NCBITaxon:10088 denotes mice
T6563 9456-9460 NCBITaxon:10088 denotes mice
T6564 9681-9685 NCBITaxon:10088 denotes mice
T6565 9894-9898 NCBITaxon:10088 denotes mice
T6566 9962-9966 NCBITaxon:10088 denotes mice
T6567 10013-10017 NCBITaxon:10088 denotes mice
T6568 10064-10068 NCBITaxon:10088 denotes mice
T9570 10307-10313 PR:000003710 denotes ADAM11
T9571 10328-10332 NCBITaxon:10088 denotes mice
T9572 10349-10355 PR:000003710 denotes Adam11
T9573 10356-10360 SO:0000704 denotes gene
T9574 10392-10398 PR:000003710 denotes Adam11
T9575 10399-10403 SO:0000704 denotes gene
T9576 10407-10416 GO:0010467 denotes expressed
T9577 10424-10429 UBERON:0000955 denotes brain
T9578 10431-10436 UBERON:0000948 denotes heart
T9579 10438-10443 UBERON:0002107 denotes liver
T9580 10448-10454 UBERON:0000473 denotes testis
T9581 10517-10523 PR:000003710 denotes ADAM11
T9582 10534-10538 NCBITaxon:10088 denotes mice
T9583 10644-10649 UBERON:0000955 denotes brain
T9584 10651-10656 UBERON:0000948 denotes heart
T9585 10658-10663 UBERON:0002107 denotes liver
T9586 10668-10674 UBERON:0000473 denotes testis
T9587 10680-10690 GO:0010467 denotes expression
T9588 10707-10713 PR:000003710 denotes Adam11
T9589 10714-10718 SO:0000704 denotes gene
T9590 10726-10731 UBERON:0000955 denotes brain
T9591 10764-10777 GO:0097617 denotes hybridisation
T9592 10810-10820 GO:0010467 denotes expression
T9593 10824-10830 PR:000003710 denotes ADAM11
T9594 10859-10869 UBERON:0002037 denotes cerebellum
T9595 10926-10936 UBERON:0002037 denotes cerebellum
T9596 10991-10997 PR:000003710 denotes ADAM11
T9597 11005-11019 UBERON:0001016 denotes nervous system
T9598 11133-11138 CHEBI:15377 denotes water
T9599 11223-11231 GO:0007612 denotes learning
T9600 11280-11286 PR:000003710 denotes ADAM11
T9601 11297-11301 NCBITaxon:10088 denotes mice
T9602 11356-11360 NCBITaxon:10088 denotes mice
T9603 11370-11378 GO:0007612 denotes learning
T9604 11524-11528 NCBITaxon:10088 denotes mice
T9605 11644-11650 PR:000003710 denotes ADAM11
T9606 11661-11665 NCBITaxon:10088 denotes mice
T9607 11800-11806 GO:0007601 denotes visual
T9608 11821-11826 NCBITaxon:10088 denotes mouse
T9609 11839-11845 PR:000003710 denotes ADAM11
T9610 11856-11860 NCBITaxon:10088 denotes mice
T9611 11903-11909 PR:000003710 denotes ADAM11
T9612 11920-11924 NCBITaxon:10088 denotes mice
T9613 11942-11950 GO:0007612 denotes learning
T9614 11967-11977 UBERON:0002037 denotes cerebellum
T9615 12021-12034 UBERON:0003945 denotes somatic motor
T9616 12045-12055 GO:0065007 denotes regulation
T9617 12164-12174 UBERON:0002037 denotes cerebellum
T9618 12238-12242 NCBITaxon:10088 denotes mice
T9619 12280-12290 UBERON:0002037 denotes cerebellum
T9620 12319-12324 SO:0000704 denotes genes
T9621 12341-12351 UBERON:0002037 denotes cerebellum
T9622 12471-12477 PR:000003710 denotes ADAM11
T9623 12488-12492 NCBITaxon:10088 denotes mice
T9624 12537-12541 NCBITaxon:10088 denotes mice
T9625 12565-12571 PR:000003710 denotes ADAM11
T9626 12582-12586 NCBITaxon:10088 denotes mice
T9627 12633-12637 NCBITaxon:10088 denotes mice
T9628 12687-12693 PR:000003710 denotes ADAM11
T9629 12704-12708 NCBITaxon:10088 denotes mice
T9630 12773-12779 GO:0007601 denotes visual
T9631 12804-12809 CHEBI:15377 denotes water
T9632 12839-12847 GO:0036268 denotes swimming
T9633 12851-12857 PR:000003710 denotes ADAM11
T9634 12868-12872 NCBITaxon:10088 denotes mice
T9635 12977-12985 GO:0036268 denotes swimming
T9636 13048-13058 UBERON:0002037 denotes cerebellum
T9637 13111-13119 GO:0007612 denotes learning
T9638 13156-13170 GO:0061743 denotes motor learning
T9639 13200-13213 _FRAGMENT denotes synaptotagmin
T9640 13220-13222 PR:000015906 denotes IV
T9641 13215-13218 _FRAGMENT denotes Syt
T9642 13233-13237 NCBITaxon:10088 denotes mice
T9643 13290-13294 NCBITaxon:10088 denotes mice
T9644 13366-13370 NCBITaxon:10088 denotes mice
T9645 13498-13504 PR:000015906 denotes Syt IV
T9646 13553-13567 GO:0061743 denotes motor learning
T9647 13614-13620 PR:000003710 denotes ADAM11
T9648 13631-13635 NCBITaxon:10088 denotes mice
T9649 13681-13695 GO:0061743 denotes motor learning
T9650 13761-13775 GO:0061743 denotes motor learning
T9651 13779-13785 PR:000003710 denotes ADAM11
T9652 13796-13800 NCBITaxon:10088 denotes mice
T9653 13894-13899 GO:0007612 denotes learn
T9654 13922-13936 GO:0061743 denotes motor learning
T9655 13948-13954 PR:000003710 denotes ADAM11
T9656 13965-13969 NCBITaxon:10088 denotes mice
T9657 14007-14017 UBERON:0002037 denotes cerebellar
T9658 14028-14036 GO:0007612 denotes learning
T9659 14054-14063 _FRAGMENT denotes classical
T9660 14071-14083 GO:0008306 denotes conditioning
T9661 14064-14070 UBERON:0001711 denotes eyelid
T9662 14163-14169 PR:000003710 denotes ADAM11
T9663 14180-14184 NCBITaxon:10088 denotes mice
T9664 14237-14243 PR:000003710 denotes ADAM11
T9665 14254-14258 NCBITaxon:10088 denotes mice
T9666 14458-14469 UBERON:0002616 denotes brain sites
T9667 14498-14508 UBERON:0002037 denotes cerebellum
T9668 14562-14570 GO:0007612 denotes learning
T9669 14611-14617 PR:000003710 denotes ADAM11
T9670 14628-14632 NCBITaxon:10088 denotes mice
T9671 14642-14655 GO:0097617 denotes hybridisation
T9672 14678-14684 PR:000003710 denotes Adam11
T9673 14685-14689 SO:0000704 denotes gene
T9674 14685-14700 GO:0010467 denotes gene expression
T9675 14708-14717 UBERON:0002929 denotes pyramidal
T9676 14708-14723 CL:0000598 denotes pyramidal cells
T9677 14727-14730 _FRAGMENT denotes CA1
T9678 14735-14741 UBERON:0003881 denotes fields
T9679 14731-14741 UBERON:0003883 denotes CA3 fields
T9680 14746-14759 CL:0000120 denotes granule cells
T9681 14767-14780 UBERON:0001885 denotes dentate gyrus
T9682 14807-14821 CL:0000120 denotes granular cells
T9683 14829-14839 UBERON:0002037 denotes cerebellum
T9684 14936-14944 GO:0007612 denotes learning
T9685 15046-15056 UBERON:0002037 denotes cerebellum
T9686 15078-15084 PR:000003710 denotes ADAM11
T9687 15095-15099 NCBITaxon:10088 denotes mice
T9688 15188-15194 PR:000003710 denotes ADAM11
T9689 15211-15217 CL:0000540 denotes neuron
T9690 15218-15224 CL:0000540 denotes neuron
T9691 15228-15234 CL:0000540 denotes neuron
T9692 15235-15245 CL:0000125 denotes glial cell
T9693 15354-15363 CHEBI:36357 denotes molecules
T9694 15373-15402 PR:000001023 denotes neural cell adhesion molecule
T9695 15394-15402 CHEBI:36357 denotes molecule
T9696 15404-15408 PR:000001023 denotes NCAM
T9697 15463-15477 UBERON:0001016 denotes nervous system
T9698 15463-15489 GO:0007399 denotes nervous system development
T9699 15541-15549 GO:0045202 denotes synaptic
T9700 15568-15573 UBERON:0007023 denotes adult
T9701 15574-15588 UBERON:0001016 denotes nervous system
T9702 15606-15612 CL:0000540 denotes neuron
T9703 15741-15763 GO:0060291 denotes long-term potentiation
T9704 15765-15768 GO:0060291 denotes LTP
T9705 15805-15813 GO:0045202 denotes synaptic
T9706 15842-15850 GO:0007612 denotes learning
T9707 15855-15861 GO:0007613 denotes memory
T9708 15899-15903 NCBITaxon:10088 denotes mice
T9709 15935-15939 _FRAGMENT denotes NR2A
T9710 15949-15957 PR:000008246 denotes subunits
T9711 15944-15957 PR:000008248 denotes NR2C subunits
T9712 16043-16055 GO:0098794 denotes postsynaptic
T9713 16076-16086 UBERON:0002037 denotes cerebellar
T9714 16076-16100 CL:0001031 denotes cerebellar granule cells
T9715 16167-16175 GO:0045202 denotes synaptic
T9716 16167-16188 GO:0007268 denotes synaptic transmission
T9717 16227-16237 UBERON:0002037 denotes cerebellum
T9718 16241-16247 PR:000003710 denotes ADAM11
T9719 16258-16262 NCBITaxon:10088 denotes mice
T9720 16315-16321 PR:000003710 denotes ADAM11
T9721 16378-16386 GO:0045202 denotes synaptic
T9722 16424-16432 GO:0045202 denotes synaptic
T9723 16433-16443 GO:0065007 denotes regulation
T9724 16445-16451 PR:000003710 denotes ADAM11
T9725 16462-16466 NCBITaxon:10088 denotes mice
T9726 16563-16571 GO:0007612 denotes learning
T9727 16614-16618 NCBITaxon:10088 denotes mice
T9728 16631-16637 PR:000003718 denotes Adam22
T9729 16638-16642 SO:0000704 denotes gene
T9730 16705-16722 UBERON:0001021 denotes peripheral nerves
T9731 16728-16732 GO:0016265 denotes died
T9732 16754-16758 NCBITaxon:10088 denotes Mice
T9733 16771-16777 PR:000003719 denotes Adam23
T9734 16778-16782 SO:0000704 denotes gene
T9735 16819-16823 GO:0016265 denotes died
T9736 16873-16879 PR:000003710 denotes ADAM11
T9737 16881-16887 PR:000003718 denotes ADAM22
T9738 16892-16898 PR:000003719 denotes ADAM23
T9739 16940-16954 UBERON:0001016 denotes nervous system
T9740 16958-16964 SO:0001026 denotes genome
T9741 16990-16999 SO:0000855 denotes orthologs
T9742 17003-17009 PR:000003710 denotes ADAM11
T9743 17011-17017 PR:000003718 denotes ADAM22
T9744 17022-17028 PR:000003719 denotes ADAM23
T9745 17029-17034 SO:0000704 denotes genes
T9746 17047-17058 NCBITaxon:7742 denotes vertebrates
T9747 17067-17074 NCBITaxon:40674 denotes mammals
T9748 17086-17096 NCBITaxon:8292 denotes amphibians
T9749 17262-17276 UBERON:0001016 denotes nervous system
T9750 17287-17296 NCBITaxon:1 denotes organisms
T11469 17310-17316 PR:000003710 denotes ADAM11
T11470 17327-17331 NCBITaxon:10088 denotes mice
T11471 17523-17533 UBERON:0001062 denotes anatomical
T11472 17595-17603 GO:0007612 denotes learning
T11473 17608-17618 UBERON:0002037 denotes cerebellum
T11474 17651-17657 PR:000003710 denotes ADAM11
T11475 17668-17672 NCBITaxon:10088 denotes mice
T11476 17705-17710 CHEBI:15377 denotes water
T11477 17744-17755 SO:0000704 denotes genetically
T11478 17765-17770 NCBITaxon:10088 denotes mouse
T11479 17893-17907 UBERON:0001016 denotes nervous system
T11814 17938-17944 PR:000003710 denotes Adam11
T11815 17945-17949 SO:0000704 denotes gene
T11816 17950-17966 SO:0001644 denotes targeting vector
T11817 17979-17984 PR:P23940 denotes BamHI
T11818 18007-18012 SO:0000147 denotes exons
T11819 18027-18033 PR:000003710 denotes Adam11
T11820 18034-18038 SO:0000704 denotes gene
T11821 18066-18073 SO:0001026 denotes genomic
T11822 18125-18128 CHEBI:60004 denotes mix
T11823 18197-18202 NCBITaxon:10088 denotes mouse
T11824 18203-18209 PR:000003710 denotes Adam11
T11825 18210-18214 SO:0000704 denotes gene
T11826 18237-18245 SO:0005853 denotes cassette
T11827 18251-18256 SO:0000147 denotes exons
T11828 18270-18276 PR:000003710 denotes Adam11
T11829 18277-18281 SO:0000704 denotes gene
T11830 18336-18343 SO:0001026 denotes genomic
T11831 18409-18417 SO:0005853 denotes cassette
T11832 18441-18449 SO:0005853 denotes cassette
T12257 18529-18535 PR:000003710 denotes Adam11
T12258 18546-18550 NCBITaxon:10088 denotes mice
T12259 18566-18582 SO:0001644 denotes targeting vector
T12260 18611-18620 UBERON:0000922 denotes embryonic
T12261 18611-18625 _FRAGMENT denotes embryonic stem
T12262 18631-18636 CL:0002322 denotes cells
T12263 18627-18629 _FRAGMENT denotes ES
T12264 18708-18715 SO:0000112 denotes primers
T12265 18774-18782 SO:0005853 denotes cassette
T12266 18839-18855 SO:0001644 denotes targeting vector
T12267 19008-19010 CL:0002322 denotes ES
T12268 19037-19047 GO:0009566 denotes fertilised
T12269 19052-19057 NCBITaxon:10088 denotes mouse
T12270 19058-19062 CL:0000025 denotes eggs
T12271 19070-19086 UBERON:0007236 denotes eight-cell stage
T12272 19121-19126 GO:0007618 denotes mated
T12273 19238-19242 NCBITaxon:10088 denotes mice
T12274 19287-19291 NCBITaxon:10088 denotes mice
T12564 19317-19322 NCBITaxon:10088 denotes Mouse
T12565 19323-19330 SO:0001026 denotes genomic
T12566 19390-19395 UBERON:0002107 denotes liver
T12567 19414-19419 PR:P23940 denotes BamHI
T12568 19429-19436 SO:0001026 denotes genomic
T12569 19462-19465 CHEBI:37972 denotes 32P
T12570 19507-19512 PR:P23940 denotes BamHI
T12571 19521-19528 SO:0001026 denotes genomic
T12572 19549-19555 SO:0000188 denotes intron
T12963 19597-19603 PR:000003710 denotes ADAM11
T12964 19625-19629 NCBITaxon:10088 denotes mice
T12965 19687-19697 UBERON:0002037 denotes cerebellum
T12966 19732-19737 NCBITaxon:10088 denotes mouse
T12967 19774-19784 GO:0019835 denotes cell lysis
T12968 19799-19803 CHEBI:9754 denotes Tris
T12969 19804-19807 CHEBI:17883 denotes HCl
T12970 19824-19828 CHEBI:26710 denotes NaCl
T12971 19833-19838 CHEBI:63016 denotes NP-40
T12972 19859-19867 CHEBI:60004 denotes cocktail
T12973 20120-20123 CHEBI:8984 denotes SDS
T12974 20151-20155 CHEBI:53250 denotes PVDF
T12975 20210-20218 GO:0042571 denotes antibody
T12976 20231-20237 PR:000003710 denotes ADAM11
T12977 20281-20291 GO:0042571 denotes antibodies
T12978 20313-20324 NCBITaxon:3704 denotes horseradish
T12979 20352-20360 GO:0042571 denotes antibody
T13395 20468-20474 NCBITaxon:33208 denotes animal
T13396 20527-20533 NCBITaxon:33208 denotes animal
T13397 20576-20582 NCBITaxon:33208 denotes Animal
T13398 20645-20651 NCBITaxon:33208 denotes Animal
T13399 20686-20692 NCBITaxon:33208 denotes Animal
T13400 20764-20770 PR:000003710 denotes ADAM11
T13401 20786-20790 NCBITaxon:10088 denotes mice
T13402 21016-21021 NCBITaxon:10088 denotes mouse
T13649 21061-21070 GO:0040011 denotes Locomotor
T13650 21131-21135 NCBITaxon:10088 denotes mice
T14330 21305-21310 CHEBI:15377 denotes Water
T14331 21329-21337 GO:0007612 denotes learning
T14332 21383-21388 CHEBI:15377 denotes water
T14333 21416-21420 NCBITaxon:10088 denotes mice
T14334 21683-21688 CHEBI:15377 denotes water
T14335 21763-21768 NCBITaxon:10088 denotes mouse
T14336 21784-21788 GO:0036268 denotes swim
T14337 22032-22038 NCBITaxon:33208 denotes animal
T14338 22244-22249 NCBITaxon:10088 denotes mouse
T14339 22364-22369 NCBITaxon:10088 denotes mouse
T14340 22436-22440 GO:0036268 denotes swim
T14341 22453-22457 GO:0036268 denotes Swim
T14342 22659-22664 NCBITaxon:10088 denotes mouse
T14343 22714-22719 NCBITaxon:10088 denotes mouse
T14344 22735-22739 GO:0036268 denotes swim
T14345 22904-22910 NCBITaxon:33208 denotes animal
T14919 23205-23209 NCBITaxon:10088 denotes mice
T14920 23473-23479 NCBITaxon:33208 denotes animal
T15156 23544-23549 NCBITaxon:10088 denotes mouse
T15157 23629-23634 NCBITaxon:10088 denotes mouse
T15158 23738-23742 UBERON:0002415 denotes tail
T15478 23817-23822 NCBITaxon:10088 denotes mouse
T15479 24323-24327 UBERON:0002415 denotes tail
T15700 24450-24455 NCBITaxon:10088 denotes mouse
T15701 24464-24468 NCBITaxon:10088 denotes mice
T15946 24940-24945 CHEBI:15377 denotes water
T16189 25156-25163 UBERON:0000479 denotes tissues
T16190 25178-25183 UBERON:0000955 denotes brain
T16191 25185-25196 UBERON:0002240 denotes spinal cord
T16192 25198-25203 UBERON:0000948 denotes heart
T16193 25205-25209 UBERON:0002048 denotes lung
T16194 25211-25216 UBERON:0002107 denotes liver
T16195 25218-25224 UBERON:0002113 denotes kidney
T16196 25226-25232 UBERON:0002106 denotes spleen
T16197 25237-25243 UBERON:0000473 denotes testis
T16198 25249-25253 NCBITaxon:10088 denotes mice
T16199 25330-25338 CHEBI:16842 denotes formalin
T16200 25418-25429 CHEBI:51686 denotes hematoxylin
R2189 T9640 T9639 _lexicallyChainedTo IV,synaptotagmin
R2190 T9640 T9641 _lexicallyChainedTo IV,Syt
R2191 T9660 T9659 _lexicallyChainedTo conditioning,classical
R2192 T9678 T9677 _lexicallyChainedTo fields,CA1
R2193 T9710 T9709 _lexicallyChainedTo subunits,NR2A
R3636 T12262 T12261 _lexicallyChainedTo cells,embryonic stem
R3637 T12262 T12263 _lexicallyChainedTo cells,ES
R220 T2024 T2023 _lexicallyChainedTo differentiation,cell
R1 T502 T501 _lexicallyChainedTo differentiation,cell

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T509 20-28 GO:0007612 denotes learning
T510 33-38 GO_EXT:biological_movement_or_translocation_process denotes motor
T511 55-61 PR_EXT:000003710 denotes ADAM11
T512 72-76 NCBITaxon:10088 denotes mice
T513 98-104 PR_EXT:000003710 denotes ADAM11
T514 129-133 SO_EXT:0000704 denotes gene
T515 155-164 GO:0010467 denotes expressed
T516 172-186 UBERON:0001016 denotes nervous system
T517 211-219 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T518 220-228 CHEBI:36357 denotes molecule
T519 280-284 CL_GO_EXT:cell denotes cell
T520 285-289 CL_GO_EXT:cell denotes cell
T521 293-297 CL_GO_EXT:cell denotes cell
T522 298-304 GO:0031012 denotes matrix
T523 336-349 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T524 363-369 PR_EXT:000003710 denotes ADAM11
T525 384-390 PR_EXT:000003710 denotes ADAM11
T526 401-405 NCBITaxon:10088 denotes mice
T527 418-422 SO_EXT:0000704 denotes gene
T528 443-449 PR_EXT:000003710 denotes ADAM11
T529 460-464 NCBITaxon:10088 denotes mice
T530 569-574 UBERON:0000955 denotes brain
T531 578-589 UBERON:0002240 denotes spinal cord
T532 599-605 PR_EXT:000003710 denotes ADAM11
T533 616-625 GO:0010467 denotes expressed
T534 633-644 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T535 649-659 UBERON:0002037 denotes cerebellum
T536 678-684 PR_EXT:000003710 denotes ADAM11
T537 685-691 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T538 692-696 NCBITaxon:10088 denotes mice
T539 701-709 GO:0007612 denotes learning
T540 716-722 GO:0007601 denotes visual
T541 734-739 CHEBI:15377 denotes water
T542 762-767 GO_EXT:biological_movement_or_translocation_process denotes motor
T543 838-844 GO:0007601 denotes visual
T544 845-850 CHEBI:15377 denotes water
T545 896-901 CHEBI:15377 denotes water
T546 952-958 PR_EXT:000003710 denotes ADAM11
T547 969-973 NCBITaxon:10088 denotes mice
T548 1013-1019 PR_EXT:000003710 denotes ADAM11
T549 1020-1028 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T550 1045-1049 CL_GO_EXT:cell denotes cell
T551 1045-1059 GO:0016477 denotes cell migration
T552 1045-1049 _FRAGMENT denotes cell
T553 1064-1079 GO:0030154 denotes differentiation
T554 1112-1120 GO:0007612 denotes learning
T555 1125-1130 GO_EXT:biological_movement_or_translocation_process denotes motor
T556 1151-1157 PR_EXT:000003710 denotes ADAM11
T557 1182-1192 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signalling
T558 1217-1221 CL_GO_EXT:cell denotes cell
T559 1222-1230 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T560 1231-1239 CHEBI:36357 denotes molecule
T561 1247-1254 GO:0045202 denotes synapse
T562 1284-1292 GO:0045202 denotes synaptic
T563 1293-1303 GO:0065007 denotes regulation
T564 1315-1326 GO_PATO_EXT:biological_behavior denotes behavioural
T2069 1376-1391 GO_EXT:0008237 denotes Metalloprotease
T2070 1410-1418 GO:0016020 denotes membrane
T2071 1434-1440 SO_EXT:0000417 denotes domain
T2072 1441-1449 CHEBI_PR_EXT:protein denotes proteins
T2073 1463-1480 GO_EXT:0008237 denotes metalloproteinase
T2074 1486-1492 SO_EXT:0000417 denotes domain
T2075 1516-1522 SO_EXT:0000417 denotes domain
T2076 1560-1573 GO_MOP_EXT:catalysis denotes catalytically
T2077 1581-1597 GO_EXT:0008237 denotes metalloproteases
T2078 1645-1654 GO_EXT:0005125 denotes cytokines
T2079 1656-1662 GO_EXT:biological_growth_entity_or_process denotes growth
T2080 1656-1670 GO_EXT:0008083 denotes growth factors
T2081 1672-1681 GO_EXT:0004872 denotes receptors
T2082 1683-1691 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T2083 1692-1701 CHEBI:36357 denotes molecules
T2084 1716-1720 SO_EXT:0000704 denotes gene
T2085 1743-1747 NCBITaxon:10088 denotes mice
T2086 1765-1778 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T2087 1811-1817 PR_EXT:000001278 denotes ADAM10
T2088 1819-1825 PR_EXT:000001279 denotes ADAM17
T2089 1830-1836 PR_EXT:000003714 denotes ADAM19
T2090 1886-1892 GO_EXT:biological_growth_entity_or_process denotes growth
T2091 1970-1975 PR_EXT:000001280 denotes ADAM8
T2092 1977-1982 PR_EXT:000003725 denotes ADAM9
T2093 1984-1990 PR_EXT:000003711 denotes ADAM12
T2094 1995-2001 PR_EXT:000003712 denotes ADAM15
T2095 2024-2037 GO:0009790 denotes embryogenesis
T2096 2094-2102 GO_EXT:0008233 denotes protease
T2097 2145-2153 GO_EXT:0008233 denotes protease
T2098 2179-2187 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T2099 2188-2197 CHEBI:36357 denotes molecules
T2100 2246-2254 GO_PR_EXT:integrin denotes integrin
T2101 2264-2268 CL_GO_EXT:cell denotes cell
T2102 2269-2277 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T2103 2343-2351 GO_PR_EXT:integrin denotes integrin
T2104 2361-2365 CL_GO_EXT:cell denotes cell
T2105 2361-2375 GO:0016477 denotes cell migration
T2106 2379-2385 UBERON:0000479 denotes tissue
T2107 2386-2399 CL:0000010 denotes culture cells
T2108 2394-2399 CL_GO_EXT:cell denotes cells
T2109 2407-2417 GO:0065007 denotes controlled
T2110 2445-2455 NCBITaxon:6239 denotes C. elegans
T2111 2457-2463 PR_EXT:000003714 denotes unc-71
T2112 2464-2468 SO_EXT:0000704 denotes gene
T2113 2469-2475 SO_EXT:sequence_coding_function denotes coding
T2114 2482-2490 GO_EXT:0008233 denotes protease
T2115 2496-2503 CHEBI_PR_EXT:protein denotes protein
T2116 2538-2542 CL_GO_EXT:cell denotes cell
T2117 2538-2552 GO:0016477 denotes cell migration
T2118 2587-2600 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T2119 2610-2619 NCBITaxon:40674 denotes mammalian
T2120 2624-2632 GO_EXT:0008233 denotes protease
T2121 2670-2677 SO_EXT:0000704 denotes Genetic
T2122 2678-2686 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2123 2698-2702 NCBITaxon:10088 denotes mice
T2124 2724-2729 PR_EXT:000003715 denotes Adam2
T2125 2730-2734 SO_EXT:sequence_nullness denotes null
T2126 2745-2749 SO_EXT:sequence_nullness denotes null
T2127 2750-2754 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T2128 2755-2762 SO_EXT:sequence_altered_entity denotes mutants
T2129 2787-2798 CL:0000019 denotes spermatozoa
T2130 2804-2807 CL:0000025 denotes egg
T2131 2808-2815 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2132 2919-2925 PR_EXT:000003710 denotes ADAM11
T2133 2927-2933 PR_EXT:000003718 denotes ADAM22
T2134 2938-2944 PR_EXT:000003719 denotes ADAM23
T2135 2945-2950 SO_EXT:0000704 denotes genes
T2136 2972-2982 GO:0010467 denotes expression
T2137 2990-2995 NCBITaxon:9606 denotes human
T2138 3000-3006 NCBITaxon:39107 denotes murine
T2139 3007-3022 UBERON:0001016 denotes nervous systems
T2140 3051-3060 GO_MOP_EXT:catalysis denotes catalytic
T2141 3061-3066 SO_EXT:sequence_or_structure_motif denotes motif
T2142 3084-3101 GO_EXT:0008237 denotes metalloproteinase
T2143 3141-3150 GO_EXT:0008233 denotes proteases
T2144 3199-3203 CL_GO_EXT:cell denotes cell
T2145 3199-3213 GO:0016477 denotes cell migration
T2146 3199-3203 _FRAGMENT denotes cell
T2147 3215-3230 GO:0030154 denotes differentiation
T2148 3247-3255 GO:0045202 denotes synaptic
T2149 3256-3266 GO:0065007 denotes regulation
T2150 3270-3277 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2151 3281-3290 GO_PR_EXT:integrin denotes integrins
T2152 3292-3296 CL_GO_EXT:cell denotes cell
T2153 3292-3304 GO:0009986 denotes cell-surface
T2154 3305-3313 CHEBI_PR_EXT:protein denotes proteins
T2155 3317-3330 GO:0005622 denotes intracellular
T2156 3317-3341 GO:0035556 denotes intracellular signalling
T2157 3322-3330 CL_GO_EXT:cell denotes cellular
T2158 3331-3351 CHEBI_EXT:62488 denotes signalling molecules
T2159 3407-3412 GO:0016265 denotes death
T2160 3450-3461 GO_EXT:myelin_assembly_or_myelination denotes myelination
T2161 3469-3494 UBERON:0000010 denotes peripheral nervous system
T2162 3498-3504 PR_EXT:000003718 denotes Adam22
T2163 3505-3509 SO_EXT:sequence_nullness denotes null
T2164 3510-3516 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2165 3517-3521 NCBITaxon:10088 denotes mice
T2166 3572-3578 PR_EXT:000003719 denotes Adam23
T2167 3579-3583 SO_EXT:0000704 denotes gene
T2168 3591-3596 NCBITaxon:10088 denotes mouse
T2169 3618-3623 GO:0016265 denotes death
T2170 3732-3737 UBERON:0000955 denotes brain
T2171 3766-3772 PR_EXT:000003718 denotes Adam22
T2172 3773-3777 SO_EXT:sequence_nullness denotes null
T2173 3782-3788 PR_EXT:000003719 denotes Adam23
T2174 3789-3793 SO_EXT:sequence_nullness denotes null
T2175 3794-3798 NCBITaxon:10088 denotes mice
T2176 3800-3806 PR_EXT:000003710 denotes ADAM11
T2177 3822-3829 SO_EXT:0000854 denotes paralog
T2178 3833-3839 PR_EXT:000003718 denotes ADAM22
T2179 3844-3850 PR_EXT:000003719 denotes ADAM23
T2180 3860-3869 SO_EXT:0000855 denotes orthologs
T2181 3889-3900 NCBITaxon:7742 denotes vertebrates
T2182 3913-3926 NCBITaxon_EXT:invertebrate denotes invertebrates
T2183 3958-3965 NCBITaxon:8353 denotes Xenopus
T2184 3966-3972 PR_EXT:000003710 denotes ADAM11
T2185 3973-3981 SO_EXT:0000855 denotes ortholog
T2186 3999-4009 GO:0010467 denotes expression
T2187 4034-4040 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T2188 4078-4082 CL_GO_EXT:cell denotes cell
T2189 4078-4092 GO:0016477 denotes cell migration
T2190 4168-4181 GO:0097617 denotes hybridisation
T2191 4199-4205 NCBITaxon:39107 denotes murine
T2192 4206-4212 PR_EXT:000003710 denotes Adam11
T2193 4213-4217 SO_EXT:0000704 denotes gene
T2194 4221-4230 GO:0010467 denotes expressed
T2195 4258-4263 UBERON:0007023 denotes adult
T2196 4264-4278 UBERON:0001016 denotes nervous system
T2197 4330-4336 PR_EXT:000003710 denotes ADAM11
T2198 4343-4351 GO_PR_EXT:integrin denotes integrin
T2199 4352-4358 CHEMINF_GO_EXT:bearer_of_chemical_binding_or_bond_formation denotes binder
T2200 4395-4409 UBERON:0001016 denotes nervous system
T2201 4417-4423 PR_EXT:000003718 denotes ADAM22
T2202 4428-4434 PR_EXT:000003719 denotes ADAM23
T2203 4453-4466 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T2204 4480-4486 PR_EXT:000003710 denotes ADAM11
T2205 4514-4520 PR_EXT:000003710 denotes Adam11
T2206 4521-4525 SO_EXT:0000704 denotes gene
T2207 4535-4539 NCBITaxon:10088 denotes mice
T3179 4565-4571 PR_EXT:000003710 denotes ADAM11
T3180 4582-4586 NCBITaxon:10088 denotes mice
T3181 4587-4591 NCBITaxon:10088 denotes Mice
T3182 4612-4620 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3183 4630-4636 PR_EXT:000003710 denotes Adam11
T3184 4637-4641 SO_EXT:0000704 denotes gene
T3185 4671-4684 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3186 4812-4829 SO_EXT:0000319 denotes termination codon
T3187 4848-4852 SO_EXT:0000147 denotes exon
T3188 4862-4873 SO_EXT:0001062 denotes pro-protein
T3189 4866-4873 CHEBI_PR_EXT:protein denotes protein
T3190 4874-4880 SO_EXT:0000417 denotes domain
T3191 4891-4900 SO_EXT:sequence_truncation_process denotes truncated
T3192 4913-4919 PR_EXT:000003710 denotes ADAM11
T3193 4920-4927 CHEBI_PR_EXT:protein denotes protein
T3194 4968-4974 SO_EXT:0001023 denotes allele
T3195 4984-4995 SO_EXT:0001062 denotes pro-protein
T3196 4988-4995 CHEBI_PR_EXT:protein denotes protein
T3197 4996-5003 SO_EXT:0000417 denotes domains
T3198 5049-5057 CHEBI_PR_EXT:protein denotes proteins
T3199 5061-5066 PR_EXT:000003137 denotes furin
T3200 5072-5081 GO_EXT:0008233 denotes proteases
T3201 5148-5157 SO_EXT:sequence_truncation_process denotes truncated
T3202 5166-5172 PR_EXT:000003710 denotes ADAM11
T3203 5173-5180 CHEBI_PR_EXT:protein denotes protein
T3204 5228-5234 PR_EXT:000003710 denotes ADAM11
T3205 5235-5242 CHEBI_PR_EXT:protein denotes protein
T3206 5257-5264 SO_EXT:sequence_altered_entity denotes mutants
T3207 5321-5329 GO:0042571 denotes antibody
T3208 5350-5356 PR_EXT:000003710 denotes ADAM11
T3209 5357-5364 CHEBI_PR_EXT:protein denotes protein
T3210 5426-5433 SO_EXT:sequence_altered_entity denotes mutants
T3211 5469-5478 SO_EXT:wild_type_entity_or_quality denotes wild-type
T3212 5489-5495 PR_EXT:000003710 denotes ADAM11
T3213 5496-5503 CHEBI_PR_EXT:protein denotes protein
T3923 5506-5512 PR_EXT:000003710 denotes ADAM11
T3924 5523-5527 NCBITaxon:10088 denotes mice
T3925 5557-5563 GO:0007618 denotes Mating
T3926 5567-5571 NCBITaxon:10088 denotes mice
T3927 5593-5599 PR_EXT:000003710 denotes ADAM11
T3928 5600-5608 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3929 5650-5659 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T3930 5694-5701 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T3931 5706-5711 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T3932 5786-5792 PR_EXT:000003710 denotes ADAM11
T3933 5803-5807 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T3934 5808-5812 NCBITaxon:10088 denotes mice
T3935 5881-5892 GO_PATO_EXT:biological_behavior denotes behavioural
T3936 5906-5916 UBERON:0001062 denotes anatomical
T3937 5950-5956 PR_EXT:000003710 denotes ADAM11
T3938 5967-5971 NCBITaxon:10088 denotes mice
T3939 6025-6031 PR_EXT:000003710 denotes Adam11
T3940 6032-6036 SO_EXT:0000704 denotes gene
T3941 6095-6099 UBERON_EXT:body denotes body
T3942 6111-6112 SO_EXT:sequence_nullness_or_absence denotes -
T3943 6113-6114 SO_EXT:sequence_nullness_or_absence denotes -
T3944 6116-6120 NCBITaxon:10088 denotes mice
T3945 6148-6149 SO_EXT:normal_or_wild_type_or_present denotes +
T3946 6150-6151 SO_EXT:normal_or_wild_type_or_present denotes +
T3947 6158-6159 SO_EXT:normal_or_wild_type_or_present denotes +
T3948 6160-6161 SO_EXT:sequence_nullness_or_absence denotes -
T3949 6163-6167 NCBITaxon:10088 denotes mice
T3950 6256-6265 GO:0040011 denotes locomotor
T3951 6282-6283 SO_EXT:normal_or_wild_type_or_present denotes +
T3952 6284-6285 SO_EXT:normal_or_wild_type_or_present denotes +
T3953 6289-6290 SO_EXT:normal_or_wild_type_or_present denotes +
T3954 6291-6292 SO_EXT:sequence_nullness_or_absence denotes -
T3955 6299-6300 SO_EXT:sequence_nullness_or_absence denotes -
T3956 6301-6302 SO_EXT:sequence_nullness_or_absence denotes -
T3957 6304-6313 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T3958 6344-6354 UBERON:0001062 denotes anatomical
T3959 6395-6406 UBERON:0002240 denotes spinal cord
T3960 6408-6413 UBERON:0000948 denotes heart
T3961 6415-6419 UBERON:0002048 denotes lung
T3962 6421-6426 UBERON:0002107 denotes liver
T3963 6428-6434 UBERON:0002113 denotes kidney
T3964 6436-6442 UBERON:0002106 denotes spleen
T3965 6444-6450 UBERON:0000473 denotes testis
T3966 6454-6459 UBERON:0000992 denotes ovary
T3967 6482-6487 UBERON:0000955 denotes brain
T3968 6492-6493 SO_EXT:sequence_nullness_or_absence denotes -
T3969 6494-6495 SO_EXT:sequence_nullness_or_absence denotes -
T3970 6497-6501 NCBITaxon:10088 denotes mice
T3971 6517-6528 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T3972 6543-6553 UBERON:0002037 denotes cerebellum
T3973 6604-6605 SO_EXT:normal_or_wild_type_or_present denotes +
T3974 6606-6607 SO_EXT:normal_or_wild_type_or_present denotes +
T3975 6611-6612 SO_EXT:normal_or_wild_type_or_present denotes +
T3976 6613-6614 SO_EXT:sequence_nullness_or_absence denotes -
T3977 6621-6622 SO_EXT:sequence_nullness_or_absence denotes -
T3978 6623-6624 SO_EXT:sequence_nullness_or_absence denotes -
T3979 6626-6630 NCBITaxon:10088 denotes mice
T3980 6652-6658 PR_EXT:000003710 denotes Adam11
T3981 6676-6685 GO:0010467 denotes expressed
T3982 6693-6704 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T3983 6709-6719 UBERON:0002037 denotes cerebellum
T3984 6732-6743 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T3985 6748-6758 UBERON:0002037 denotes cerebellum
T3986 6769-6780 GO_PATO_EXT:biological_behavior denotes behavioural
T5148 7892-7898 PR_EXT:000003710 denotes Adam11
T5149 6800-6808 GO:0007612 denotes learning
T5150 6812-6818 PR_EXT:000003710 denotes ADAM11
T5151 6829-6833 NCBITaxon:10088 denotes mice
T5152 6860-6866 PR_EXT:000003710 denotes ADAM11
T5153 6874-6885 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T5154 6911-6919 GO:0007612 denotes learning
T5155 6931-6937 PR_EXT:000003710 denotes ADAM11
T5156 6948-6952 NCBITaxon:10088 denotes mice
T5157 6970-6975 CHEBI:15377 denotes Water
T5158 6999-7003 NCBITaxon:10088 denotes mice
T5159 7053-7057 NCBITaxon:10088 denotes mice
T5160 7111-7116 CHEBI:15377 denotes water
T5161 7118-7124 PR_EXT:000003710 denotes Adam11
T5162 7126-7127 SO_EXT:sequence_nullness_or_absence denotes -
T5163 7128-7129 SO_EXT:sequence_nullness_or_absence denotes -
T5164 7131-7135 NCBITaxon:10088 denotes mice
T5165 7219-7220 SO_EXT:normal_or_wild_type_or_present denotes +
T5166 7221-7222 SO_EXT:normal_or_wild_type_or_present denotes +
T5167 7229-7230 SO_EXT:normal_or_wild_type_or_present denotes +
T5168 7231-7232 SO_EXT:sequence_nullness_or_absence denotes -
T5169 7234-7238 NCBITaxon:10088 denotes mice
T5170 7279-7280 SO_EXT:normal_or_wild_type_or_present denotes +
T5171 7281-7282 SO_EXT:normal_or_wild_type_or_present denotes +
T5172 7286-7287 SO_EXT:normal_or_wild_type_or_present denotes +
T5173 7288-7289 SO_EXT:sequence_nullness_or_absence denotes -
T5174 7296-7297 SO_EXT:sequence_nullness_or_absence denotes -
T5175 7298-7299 SO_EXT:sequence_nullness_or_absence denotes -
T5176 7301-7305 NCBITaxon:10088 denotes mice
T5177 7380-7381 SO_EXT:normal_or_wild_type_or_present denotes +
T5178 7382-7383 SO_EXT:normal_or_wild_type_or_present denotes +
T5179 7387-7388 SO_EXT:normal_or_wild_type_or_present denotes +
T5180 7389-7390 SO_EXT:sequence_nullness_or_absence denotes -
T5181 7397-7398 SO_EXT:sequence_nullness_or_absence denotes -
T5182 7399-7400 SO_EXT:sequence_nullness_or_absence denotes -
T5183 7402-7406 NCBITaxon:10088 denotes mice
T5184 7420-7425 GO:0007612 denotes learn
T5185 7521-7522 SO_EXT:sequence_nullness_or_absence denotes -
T5186 7523-7524 SO_EXT:sequence_nullness_or_absence denotes -
T5187 7526-7530 NCBITaxon:10088 denotes mice
T5188 7576-7577 SO_EXT:normal_or_wild_type_or_present denotes +
T5189 7578-7579 SO_EXT:normal_or_wild_type_or_present denotes +
T5190 7586-7587 SO_EXT:normal_or_wild_type_or_present denotes +
T5191 7588-7589 SO_EXT:sequence_nullness_or_absence denotes -
T5192 7591-7595 NCBITaxon:10088 denotes mice
T5193 7742-7746 NCBITaxon:10088 denotes mice
T5194 7763-7767 GO:0036268 denotes swim
T5195 7829-7830 SO_EXT:sequence_nullness_or_absence denotes -
T5196 7831-7832 SO_EXT:sequence_nullness_or_absence denotes -
T5197 7871-7872 SO_EXT:normal_or_wild_type_or_present denotes +
T5198 7873-7874 SO_EXT:normal_or_wild_type_or_present denotes +
T5199 7876-7880 NCBITaxon:10088 denotes mice
T5200 7900-7901 SO_EXT:normal_or_wild_type_or_present denotes +
T5201 7902-7903 SO_EXT:sequence_nullness_or_absence denotes -
T5202 7905-7909 NCBITaxon:10088 denotes mice
T5203 8016-8017 SO_EXT:normal_or_wild_type_or_present denotes +
T5204 8018-8019 SO_EXT:normal_or_wild_type_or_present denotes +
T5205 8026-8027 SO_EXT:normal_or_wild_type_or_present denotes +
T5206 8028-8029 SO_EXT:sequence_nullness_or_absence denotes -
T5207 8031-8035 NCBITaxon:10088 denotes mice
T5208 8080-8088 GO:0007612 denotes learning
T5209 8104-8105 SO_EXT:sequence_nullness_or_absence denotes -
T5210 8106-8107 SO_EXT:sequence_nullness_or_absence denotes -
T5211 8109-8113 NCBITaxon:10088 denotes mice
T5212 8119-8127 GO:0036268 denotes swimming
T5213 8141-8142 SO_EXT:normal_or_wild_type_or_present denotes +
T5214 8143-8144 SO_EXT:normal_or_wild_type_or_present denotes +
T5215 8148-8149 SO_EXT:normal_or_wild_type_or_present denotes +
T5216 8150-8151 SO_EXT:sequence_nullness_or_absence denotes -
T5217 8158-8159 SO_EXT:sequence_nullness_or_absence denotes -
T5218 8160-8161 SO_EXT:sequence_nullness_or_absence denotes -
T5219 8163-8167 NCBITaxon:10088 denotes mice
T5220 8273-8277 NCBITaxon:10088 denotes mice
T5221 8284-8285 SO_EXT:normal_or_wild_type_or_present denotes +
T5222 8286-8287 SO_EXT:normal_or_wild_type_or_present denotes +
T5223 8291-8292 SO_EXT:normal_or_wild_type_or_present denotes +
T5224 8293-8294 SO_EXT:sequence_nullness_or_absence denotes -
T5225 8301-8302 SO_EXT:sequence_nullness_or_absence denotes -
T5226 8303-8304 SO_EXT:sequence_nullness_or_absence denotes -
T5227 8306-8315 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T5228 8473-8474 SO_EXT:sequence_nullness_or_absence denotes -
T5229 8475-8476 SO_EXT:sequence_nullness_or_absence denotes -
T5230 8478-8482 NCBITaxon:10088 denotes mice
T5231 8483-8488 GO:0007612 denotes learn
T5232 8533-8534 SO_EXT:normal_or_wild_type_or_present denotes +
T5233 8535-8536 SO_EXT:normal_or_wild_type_or_present denotes +
T5234 8543-8544 SO_EXT:normal_or_wild_type_or_present denotes +
T5235 8545-8546 SO_EXT:sequence_nullness_or_absence denotes -
T5236 8548-8552 NCBITaxon:10088 denotes mice
T5237 8589-8590 SO_EXT:sequence_nullness_or_absence denotes -
T5238 8591-8592 SO_EXT:sequence_nullness_or_absence denotes -
T5239 8594-8598 NCBITaxon:10088 denotes mice
T5240 8623-8628 GO_EXT:biological_movement_or_translocation_process denotes motor
T5241 8671-8676 CHEBI:15377 denotes water
T6569 8689-8694 GO_EXT:biological_movement_or_translocation_process denotes Motor
T6570 8707-8713 PR_EXT:000003710 denotes ADAM11
T6571 8724-8728 NCBITaxon:10088 denotes mice
T6572 8755-8761 PR_EXT:000003710 denotes ADAM11
T6573 8769-8779 UBERON:0002037 denotes cerebellum
T6574 8797-8802 GO_EXT:biological_movement_or_translocation_process denotes motor
T6575 8815-8821 PR_EXT:000003710 denotes ADAM11
T6576 8832-8836 NCBITaxon:10088 denotes mice
T6577 8918-8919 SO_EXT:normal_or_wild_type_or_present denotes +
T6578 8920-8921 SO_EXT:sequence_nullness_or_absence denotes -
T6579 8928-8929 SO_EXT:sequence_nullness_or_absence denotes -
T6580 8930-8931 SO_EXT:sequence_nullness_or_absence denotes -
T6581 8933-8937 NCBITaxon:10088 denotes mice
T6582 8995-8996 SO_EXT:normal_or_wild_type_or_present denotes +
T6583 8997-8998 SO_EXT:normal_or_wild_type_or_present denotes +
T6584 9000-9004 NCBITaxon:10088 denotes mice
T6585 9028-9029 SO_EXT:normal_or_wild_type_or_present denotes +
T6586 9030-9031 SO_EXT:sequence_nullness_or_absence denotes -
T6587 9061-9062 SO_EXT:sequence_nullness_or_absence denotes -
T6588 9063-9064 SO_EXT:sequence_nullness_or_absence denotes -
T6589 9110-9111 SO_EXT:normal_or_wild_type_or_present denotes +
T6590 9112-9113 SO_EXT:sequence_nullness_or_absence denotes -
T6591 9115-9119 NCBITaxon:10088 denotes mice
T6592 9242-9243 SO_EXT:normal_or_wild_type_or_present denotes +
T6593 9244-9245 SO_EXT:normal_or_wild_type_or_present denotes +
T6594 9252-9253 SO_EXT:normal_or_wild_type_or_present denotes +
T6595 9254-9255 SO_EXT:sequence_nullness_or_absence denotes -
T6596 9257-9261 NCBITaxon:10088 denotes mice
T6597 9404-9405 SO_EXT:sequence_nullness_or_absence denotes -
T6598 9406-9407 SO_EXT:sequence_nullness_or_absence denotes -
T6599 9409-9413 NCBITaxon:10088 denotes mice
T6600 9451-9452 SO_EXT:normal_or_wild_type_or_present denotes +
T6601 9453-9454 SO_EXT:normal_or_wild_type_or_present denotes +
T6602 9456-9460 NCBITaxon:10088 denotes mice
T6603 9676-9677 SO_EXT:sequence_nullness_or_absence denotes -
T6604 9678-9679 SO_EXT:sequence_nullness_or_absence denotes -
T6605 9681-9685 NCBITaxon:10088 denotes mice
T6606 9889-9890 SO_EXT:sequence_nullness_or_absence denotes -
T6607 9891-9892 SO_EXT:sequence_nullness_or_absence denotes -
T6608 9894-9898 NCBITaxon:10088 denotes mice
T6609 9947-9948 SO_EXT:normal_or_wild_type_or_present denotes +
T6610 9949-9950 SO_EXT:normal_or_wild_type_or_present denotes +
T6611 9957-9958 SO_EXT:normal_or_wild_type_or_present denotes +
T6612 9959-9960 SO_EXT:sequence_nullness_or_absence denotes -
T6613 9962-9966 NCBITaxon:10088 denotes mice
T6614 10008-10009 SO_EXT:sequence_nullness_or_absence denotes -
T6615 10010-10011 SO_EXT:sequence_nullness_or_absence denotes -
T6616 10013-10017 NCBITaxon:10088 denotes mice
T6617 10049-10050 SO_EXT:normal_or_wild_type_or_present denotes +
T6618 10051-10052 SO_EXT:normal_or_wild_type_or_present denotes +
T6619 10059-10060 SO_EXT:normal_or_wild_type_or_present denotes +
T6620 10061-10062 SO_EXT:sequence_nullness_or_absence denotes -
T6621 10064-10068 NCBITaxon:10088 denotes mice
T6622 10216-10225 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T9751 10307-10313 PR_EXT:000003710 denotes ADAM11
T9752 10328-10332 NCBITaxon:10088 denotes mice
T9753 10349-10355 PR_EXT:000003710 denotes Adam11
T9754 10356-10360 SO_EXT:0000704 denotes gene
T9755 10392-10398 PR_EXT:000003710 denotes Adam11
T9756 10399-10403 SO_EXT:0000704 denotes gene
T9757 10407-10416 GO:0010467 denotes expressed
T9758 10424-10429 UBERON:0000955 denotes brain
T9759 10431-10436 UBERON:0000948 denotes heart
T9760 10438-10443 UBERON:0002107 denotes liver
T9761 10448-10454 UBERON:0000473 denotes testis
T9762 10517-10523 PR_EXT:000003710 denotes ADAM11
T9763 10534-10538 NCBITaxon:10088 denotes mice
T9764 10644-10649 UBERON:0000955 denotes brain
T9765 10651-10656 UBERON:0000948 denotes heart
T9766 10658-10663 UBERON:0002107 denotes liver
T9767 10668-10674 UBERON:0000473 denotes testis
T9768 10680-10690 GO:0010467 denotes expression
T9769 10707-10713 PR_EXT:000003710 denotes Adam11
T9770 10714-10718 SO_EXT:0000704 denotes gene
T9771 10726-10731 UBERON:0000955 denotes brain
T9772 10764-10777 GO:0097617 denotes hybridisation
T9773 10810-10820 GO:0010467 denotes expression
T9774 10824-10830 PR_EXT:000003710 denotes ADAM11
T9775 10831-10835 CHEBI_SO_EXT:mRNA denotes mRNA
T9776 10843-10854 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9777 10859-10869 UBERON:0002037 denotes cerebellum
T9778 10909-10920 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9779 10926-10936 UBERON:0002037 denotes cerebellum
T9780 10947-10958 GO_PATO_EXT:biological_behavior denotes behavioural
T9781 10991-10997 PR_EXT:000003710 denotes ADAM11
T9782 11005-11019 UBERON:0001016 denotes nervous system
T9783 11052-11063 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9784 11133-11138 CHEBI:15377 denotes water
T9785 11171-11182 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampal
T9786 11223-11231 GO:0007612 denotes learning
T9787 11280-11286 PR_EXT:000003710 denotes ADAM11
T9788 11297-11301 NCBITaxon:10088 denotes mice
T9789 11346-11355 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9790 11356-11360 NCBITaxon:10088 denotes mice
T9791 11370-11378 GO:0007612 denotes learning
T9792 11514-11523 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9793 11524-11528 NCBITaxon:10088 denotes mice
T9794 11644-11650 PR_EXT:000003710 denotes ADAM11
T9795 11661-11665 NCBITaxon:10088 denotes mice
T9796 11782-11787 GO_EXT:biological_movement_or_translocation_process denotes motor
T9797 11800-11806 GO:0007601 denotes visual
T9798 11821-11826 NCBITaxon:10088 denotes mouse
T9799 11839-11845 PR_EXT:000003710 denotes ADAM11
T9800 11856-11860 NCBITaxon:10088 denotes mice
T9801 11903-11909 PR_EXT:000003710 denotes ADAM11
T9802 11920-11924 NCBITaxon:10088 denotes mice
T9803 11942-11950 GO:0007612 denotes learning
T9804 11967-11977 UBERON:0002037 denotes cerebellum
T9805 12021-12034 UBERON:0003945 denotes somatic motor
T9806 12029-12034 GO_EXT:biological_movement_or_translocation_process denotes motor
T9807 12045-12055 GO:0065007 denotes regulation
T9808 12059-12065 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T9809 12164-12174 UBERON:0002037 denotes cerebellum
T9810 12238-12242 NCBITaxon:10088 denotes mice
T9811 12280-12290 UBERON:0002037 denotes cerebellum
T9812 12319-12324 SO_EXT:0000704 denotes genes
T9813 12341-12351 UBERON:0002037 denotes cerebellum
T9814 12471-12477 PR_EXT:000003710 denotes ADAM11
T9815 12488-12492 NCBITaxon:10088 denotes mice
T9816 12527-12536 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9817 12537-12541 NCBITaxon:10088 denotes mice
T9818 12565-12571 PR_EXT:000003710 denotes ADAM11
T9819 12582-12586 NCBITaxon:10088 denotes mice
T9820 12623-12632 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9821 12633-12637 NCBITaxon:10088 denotes mice
T9822 12687-12693 PR_EXT:000003710 denotes ADAM11
T9824 12727-12732 GO_EXT:biological_movement_or_translocation_process denotes motor
T9825 12773-12779 GO:0007601 denotes visual
T9826 12804-12809 CHEBI:15377 denotes water
T9827 12821-12826 GO_EXT:biological_movement_or_translocation_process denotes motor
T9828 12839-12847 GO:0036268 denotes swimming
T9829 12851-12857 PR_EXT:000003710 denotes ADAM11
T9830 12868-12872 NCBITaxon:10088 denotes mice
T9831 12954-12959 GO_EXT:biological_movement_or_translocation_process denotes motor
T9832 12977-12985 GO:0036268 denotes swimming
T9833 13048-13058 UBERON:0002037 denotes cerebellum
T9834 13111-13119 GO:0007612 denotes learning
T9835 13146-13154 GO_EXT:biological_movement_or_translocation_process denotes movement
T9836 13156-13170 GO:0061743 denotes motor learning
T9837 13200-13213 _FRAGMENT denotes synaptotagmin
T9838 13220-13222 PR_EXT:000015906 denotes IV
T9839 13215-13218 _FRAGMENT denotes Syt
T9840 13233-13237 NCBITaxon:10088 denotes mice
T9841 13280-13289 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9842 13290-13294 NCBITaxon:10088 denotes mice
T9843 13356-13365 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9844 13366-13370 NCBITaxon:10088 denotes mice
T9845 13498-13504 PR_EXT:000015906 denotes Syt IV
T9846 13505-13512 SO_EXT:sequence_altered_entity denotes mutants
T9847 13519-13524 GO_EXT:biological_movement_or_translocation_process denotes motor
T9848 13553-13567 GO:0061743 denotes motor learning
T9849 13614-13620 PR_EXT:000003710 denotes ADAM11
T9850 13631-13635 NCBITaxon:10088 denotes mice
T9851 13681-13695 GO:0061743 denotes motor learning
T9852 13761-13775 GO:0061743 denotes motor learning
T9853 13779-13785 PR_EXT:000003710 denotes ADAM11
T9854 13796-13800 NCBITaxon:10088 denotes mice
T9855 13894-13899 GO:0007612 denotes learn
T9856 13922-13936 GO:0061743 denotes motor learning
T9857 13948-13954 PR_EXT:000003710 denotes ADAM11
T9858 13965-13969 NCBITaxon:10088 denotes mice
T9859 14007-14017 UBERON:0002037 denotes cerebellar
T9860 14028-14036 GO:0007612 denotes learning
T9861 14054-14063 _FRAGMENT denotes classical
T9862 14071-14083 GO:0008306 denotes conditioning
T9863 14064-14070 UBERON:0001711 denotes eyelid
T9864 14163-14169 PR_EXT:000003710 denotes ADAM11
T9865 14180-14184 NCBITaxon:10088 denotes mice
T9866 14198-14203 GO_EXT:biological_movement_or_translocation_process denotes motor
T9867 14237-14243 PR_EXT:000003710 denotes ADAM11
T9868 14254-14258 NCBITaxon:10088 denotes mice
T9869 14373-14379 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T9870 14458-14469 UBERON:0002616 denotes brain sites
T9871 14482-14493 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9872 14498-14508 UBERON:0002037 denotes cerebellum
T9873 14562-14570 GO:0007612 denotes learning
T9874 14586-14591 GO_EXT:biological_movement_or_translocation_process denotes motor
T9875 14611-14617 PR_EXT:000003710 denotes ADAM11
T9876 14628-14632 NCBITaxon:10088 denotes mice
T9877 14642-14655 GO:0097617 denotes hybridisation
T9878 14678-14684 PR_EXT:000003710 denotes Adam11
T9879 14685-14689 SO_EXT:0000704 denotes gene
T9880 14685-14700 GO:0010467 denotes gene expression
T9881 14708-14717 UBERON:0002929 denotes pyramidal
T9882 14708-14723 CL:0000598 denotes pyramidal cells
T9883 14718-14723 CL_GO_EXT:cell denotes cells
T9884 14727-14730 _FRAGMENT denotes CA1
T9885 14735-14741 UBERON:0003881 denotes fields
T9886 14731-14741 UBERON:0003883 denotes CA3 fields
T9887 14746-14759 CL:0000120 denotes granule cells
T9888 14754-14759 CL_GO_EXT:cell denotes cells
T9889 14767-14780 UBERON:0001885 denotes dentate gyrus
T9890 14788-14799 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9891 14807-14821 CL:0000120 denotes granular cells
T9892 14816-14821 CL_GO_EXT:cell denotes cells
T9893 14829-14839 UBERON:0002037 denotes cerebellum
T9894 14936-14944 GO:0007612 denotes learning
T9895 14949-14954 GO_EXT:biological_movement_or_translocation_process denotes motor
T9896 15030-15041 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9897 15046-15056 UBERON:0002037 denotes cerebellum
T9898 15078-15084 PR_EXT:000003710 denotes ADAM11
T9899 15095-15099 NCBITaxon:10088 denotes mice
T9900 15188-15194 PR_EXT:000003710 denotes ADAM11
T9901 15211-15217 CL:0000540 denotes neuron
T9902 15218-15224 CL:0000540 denotes neuron
T9903 15228-15234 CL:0000540 denotes neuron
T9904 15235-15245 CL:0000125 denotes glial cell
T9905 15241-15245 CL_GO_EXT:cell denotes cell
T9906 15345-15353 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T9907 15354-15363 CHEBI:36357 denotes molecules
T9921 15633-15644 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9922 15741-15763 GO:0060291 denotes long-term potentiation
T9923 15765-15768 GO:0060291 denotes LTP
T9924 15805-15813 GO:0045202 denotes synaptic
T9925 15842-15850 GO:0007612 denotes learning
T9926 15855-15861 GO:0007613 denotes memory
T9927 15899-15903 NCBITaxon:10088 denotes mice
T9928 15912-15916 CHEBI_EXT:NMDA denotes NMDA
T9929 15912-15925 GO_EXT:0004972 denotes NMDA receptor
T9930 15935-15939 _FRAGMENT denotes NR2A
T9931 15949-15957 PR_EXT:000008246 denotes subunits
T9932 15944-15957 PR_EXT:000008248 denotes NR2C subunits
T9933 15965-15970 GO_EXT:biological_movement_or_translocation_process denotes motor
T9934 16043-16055 GO:0098794 denotes postsynaptic
T9935 16076-16086 UBERON:0002037 denotes cerebellar
T9936 16076-16100 CL:0001031 denotes cerebellar granule cells
T9937 16095-16100 CL_GO_EXT:cell denotes cells
T9938 16167-16175 GO:0045202 denotes synaptic
T9939 16167-16188 GO:0007268 denotes synaptic transmission
T9940 16211-16222 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T9941 16227-16237 UBERON:0002037 denotes cerebellum
T9942 16241-16247 PR_EXT:000003710 denotes ADAM11
T9943 16258-16262 NCBITaxon:10088 denotes mice
T9944 16315-16321 PR_EXT:000003710 denotes ADAM11
T9945 16341-16351 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signalling
T9946 16378-16386 GO:0045202 denotes synaptic
T9947 16424-16432 GO:0045202 denotes synaptic
T9948 16433-16443 GO:0065007 denotes regulation
T9949 16445-16451 PR_EXT:000003710 denotes ADAM11
T9950 16462-16466 NCBITaxon:10088 denotes mice
T9951 16563-16571 GO:0007612 denotes learning
T9952 16576-16581 GO_EXT:biological_movement_or_translocation_process denotes motor
T9953 16614-16618 NCBITaxon:10088 denotes mice
T9954 16631-16637 PR_EXT:000003718 denotes Adam22
T9955 16638-16642 SO_EXT:0000704 denotes gene
T9956 16686-16697 GO_EXT:myelin_assembly_or_myelination denotes myelination
T9957 16705-16722 UBERON:0001021 denotes peripheral nerves
T9958 16728-16732 GO:0016265 denotes died
T9959 16754-16758 NCBITaxon:10088 denotes Mice
T9960 16771-16777 PR_EXT:000003719 denotes Adam23
T9961 16778-16782 SO_EXT:0000704 denotes gene
T9962 16819-16823 GO:0016265 denotes died
T9963 16873-16879 PR_EXT:000003710 denotes ADAM11
T9964 16881-16887 PR_EXT:000003718 denotes ADAM22
T9965 16892-16898 PR_EXT:000003719 denotes ADAM23
T9966 16940-16954 UBERON:0001016 denotes nervous system
T9967 16958-16964 SO_EXT:0001026 denotes genome
T9968 16990-16999 SO_EXT:0000855 denotes orthologs
T9969 17003-17009 PR_EXT:000003710 denotes ADAM11
T9970 17011-17017 PR_EXT:000003718 denotes ADAM22
T9971 17022-17028 PR_EXT:000003719 denotes ADAM23
T9972 17029-17034 SO_EXT:0000704 denotes genes
T9973 17047-17058 NCBITaxon:7742 denotes vertebrates
T9974 17067-17074 NCBITaxon:40674 denotes mammals
T9975 17076-17080 NCBITaxon_EXT:fish denotes fish
T9976 17086-17096 NCBITaxon:8292 denotes amphibians
T9977 17109-17122 NCBITaxon_EXT:invertebrate denotes invertebrates
T9978 17145-17154 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T9979 17262-17276 UBERON:0001016 denotes nervous system
T9980 17287-17296 NCBITaxon:1 denotes organisms
T11480 17310-17316 PR_EXT:000003710 denotes ADAM11
T11481 17327-17331 NCBITaxon:10088 denotes mice
T11482 17413-17417 UBERON_EXT:body denotes body
T11483 17443-17448 GO_EXT:biological_movement_or_translocation_process denotes motor
T11484 17459-17465 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T11485 17523-17533 UBERON:0001062 denotes anatomical
T11486 17565-17576 UBERON_EXT:hippocampus_proper_or_hippocampal_formation denotes hippocampus
T11487 17595-17603 GO:0007612 denotes learning
T11488 17608-17618 UBERON:0002037 denotes cerebellum
T11489 17629-17634 GO_EXT:biological_movement_or_translocation_process denotes motor
T11490 17651-17657 PR_EXT:000003710 denotes ADAM11
T11491 17668-17672 NCBITaxon:10088 denotes mice
T11492 17705-17710 CHEBI:15377 denotes water
T11493 17744-17755 SO_EXT:0000704 denotes genetically
T11494 17756-17764 SO_EXT:sequence_alteration_process denotes modified
T11495 17765-17770 NCBITaxon:10088 denotes mouse
T11496 17866-17874 CHEBI_PR_EXT:protein denotes proteins
T11497 17893-17907 UBERON:0001016 denotes nervous system
T11833 17938-17944 PR_EXT:000003710 denotes Adam11
T11834 17945-17949 SO_EXT:0000704 denotes gene
T11835 17950-17966 SO_EXT:0001644 denotes targeting vector
T11836 17977-17978 CHEBI_SO_EXT:base denotes b
T11837 17979-17984 PR_EXT:P23940 denotes BamHI
T11838 17985-17988 CHEBI_SO_EXT:DNA denotes DNA
T11839 18007-18012 SO_EXT:0000147 denotes exons
T11840 18027-18033 PR_EXT:000003710 denotes Adam11
T11841 18034-18038 SO_EXT:0000704 denotes gene
T11842 18066-18077 SO_EXT:genomic_DNA denotes genomic DNA
T11843 18074-18077 CHEBI_SO_EXT:DNA denotes DNA
T11844 18114-18124 GO_EXT:polymerase denotes polymerase
T11845 18125-18128 CHEBI:60004 denotes mix
T11846 18181-18189 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T11847 18197-18202 NCBITaxon:10088 denotes mouse
T11848 18203-18209 PR_EXT:000003710 denotes Adam11
T11849 18210-18214 SO_EXT:0000704 denotes gene
T11850 18219-18227 SO_EXT:sequence_insertion_process denotes inserted
T11851 18237-18245 SO_EXT:0005853 denotes cassette
T11852 18251-18256 SO_EXT:0000147 denotes exons
T11853 18270-18276 PR_EXT:000003710 denotes Adam11
T11854 18277-18281 SO_EXT:0000704 denotes gene
T11855 18303-18312 SO_EXT:engineered_biological_sequence denotes construct
T11856 18334-18335 CHEBI_SO_EXT:base denotes b
T11857 18336-18347 SO_EXT:genomic_DNA denotes genomic DNA
T11858 18344-18347 CHEBI_SO_EXT:DNA denotes DNA
T11859 18385-18394 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T11860 18409-18417 SO_EXT:0005853 denotes cassette
T11861 18438-18440 GO_PR_EXT:thymidine_kinase denotes TK
T11862 18441-18449 SO_EXT:0005853 denotes cassette
T11863 18474-18480 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T12275 18529-18535 PR_EXT:000003710 denotes Adam11
T12276 18546-18550 NCBITaxon:10088 denotes mice
T12277 18555-18565 SO_EXT:sequence_linearization denotes linearised
T12278 18566-18582 SO_EXT:0001644 denotes targeting vector
T12279 18611-18620 UBERON:0000922 denotes embryonic
T12280 18611-18625 _FRAGMENT denotes embryonic stem
T12281 18631-18636 CL:0002322 denotes cells
T12282 18627-18629 _FRAGMENT denotes ES
T12283 18631-18636 CL_GO_EXT:cell denotes cells
T12284 18654-18666 SO_EXT:sequence_recombinant_entity denotes recombinants
T12285 18708-18715 SO_EXT:0000112 denotes primers
T12286 18774-18782 SO_EXT:0005853 denotes cassette
T12287 18839-18855 SO_EXT:0001644 denotes targeting vector
T12288 18868-18878 GO_SO_EXT:sequence_rearrangement_process denotes recombined
T12289 18879-18882 CHEBI_SO_EXT:DNA denotes DNA
T12290 19008-19010 CL:0002322 denotes ES
T12291 19011-19017 SO_EXT:sequence_cloned_entity denotes clones
T12292 19037-19047 GO:0009566 denotes fertilised
T12293 19052-19057 NCBITaxon:10088 denotes mouse
T12294 19058-19062 CL:0000025 denotes eggs
T12295 19070-19086 UBERON:0007236 denotes eight-cell stage
T12296 19076-19080 CL_GO_EXT:cell denotes cell
T12297 19102-19106 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T12298 19121-19126 GO:0007618 denotes mated
T12299 19144-19151 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T12300 19217-19218 SO_EXT:normal_or_wild_type_or_present denotes +
T12301 19219-19220 SO_EXT:sequence_nullness_or_absence denotes -
T12302 19222-19226 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T12303 19231-19237 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T12304 19238-19242 NCBITaxon:10088 denotes mice
T12305 19253-19257 GO_EXT:breeding denotes bred
T12306 19282-19283 SO_EXT:sequence_nullness_or_absence denotes -
T12307 19284-19285 SO_EXT:sequence_nullness_or_absence denotes -
T12308 19287-19291 NCBITaxon:10088 denotes mice
T12573 19317-19322 NCBITaxon:10088 denotes Mouse
T12574 19323-19334 SO_EXT:genomic_DNA denotes genomic DNA
T12575 19331-19334 CHEBI_SO_EXT:DNA denotes DNA
T12576 19390-19395 UBERON:0002107 denotes liver
T12577 19404-19412 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T12578 19414-19419 PR_EXT:P23940 denotes BamHI
T12579 19429-19440 SO_EXT:genomic_DNA denotes genomic DNA
T12580 19437-19440 CHEBI_SO_EXT:DNA denotes DNA
T12581 19462-19465 CHEBI:37972 denotes 32P
T12582 19467-19475 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelled
T12583 19481-19486 CHEBI_SO_EXT:molecular_probe denotes probe
T12584 19505-19506 CHEBI_SO_EXT:base denotes b
T12585 19507-19512 PR_EXT:P23940 denotes BamHI
T12586 19521-19528 SO_EXT:0001026 denotes genomic
T12587 19549-19555 SO_EXT:0000188 denotes intron
T12980 19597-19603 PR_EXT:000003710 denotes ADAM11
T12981 19604-19611 CHEBI_PR_EXT:protein denotes protein
T12982 19620-19621 SO_EXT:sequence_nullness_or_absence denotes -
T12983 19622-19623 SO_EXT:sequence_nullness_or_absence denotes -
T12984 19625-19629 NCBITaxon:10088 denotes mice
T12985 19687-19697 UBERON:0002037 denotes cerebellum
T12986 19732-19737 NCBITaxon:10088 denotes mouse
T12987 19746-19754 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T12988 19774-19778 CL_GO_EXT:cell denotes cell
T12989 19774-19784 GO:0019835 denotes cell lysis
T12990 19785-19791 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T12991 19799-19803 CHEBI:9754 denotes Tris
T12992 19804-19807 CHEBI:17883 denotes HCl
T12993 19824-19828 CHEBI:26710 denotes NaCl
T12994 19833-19838 CHEBI:63016 denotes NP-40
T12995 19840-19858 CHEBI_GO_EXT:peptidase_or_protease_or_proteinase_inhibitor denotes protease inhibitor
T12996 19859-19867 CHEBI:60004 denotes cocktail
T12997 19907-19911 CL_GO_EXT:cell denotes cell
T12998 19942-19954 GO_MOP_EXT:glycosylation denotes glycosylated
T12999 19955-19963 CHEBI_PR_EXT:protein denotes proteins
T13000 20120-20123 CHEBI:8984 denotes SDS
T13001 20134-20145 GO_EXT:biological_movement_or_translocation_process denotes transferred
T13002 20151-20155 CHEBI:53250 denotes PVDF
T13003 20210-20218 GO:0042571 denotes antibody
T13004 20231-20237 PR_EXT:000003710 denotes ADAM11
T13005 20275-20280 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes Bound
T13006 20281-20291 GO:0042571 denotes antibodies
T13007 20313-20324 NCBITaxon:3704 denotes horseradish
T13008 20325-20335 GO_EXT:0004601 denotes peroxidase
T13009 20336-20344 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelled
T13010 20352-20360 GO:0042571 denotes antibody
T13403 20443-20454 GO_PATO_EXT:biological_behavior denotes Behavioural
T13404 20468-20474 NCBITaxon:33208 denotes animal
T13405 20527-20533 NCBITaxon:33208 denotes animal
T13406 20576-20582 NCBITaxon:33208 denotes Animal
T13407 20645-20651 NCBITaxon:33208 denotes Animal
T13408 20686-20692 NCBITaxon:33208 denotes Animal
T13409 20764-20770 PR_EXT:000003710 denotes ADAM11
T13410 20781-20785 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T13411 20786-20790 NCBITaxon:10088 denotes mice
T13412 20859-20870 GO_PATO_EXT:biological_behavior denotes behavioural
T13413 20913-20924 GO_PATO_EXT:biological_behavior denotes behavioural
T13414 21016-21021 NCBITaxon:10088 denotes mouse
T13415 21022-21031 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T13651 21046-21051 GO_EXT:biological_movement_or_translocation_process denotes motor
T13652 21061-21070 GO:0040011 denotes Locomotor
T13653 21131-21135 NCBITaxon:10088 denotes mice
T13654 21137-21138 SO_EXT:normal_or_wild_type_or_present denotes +
T13655 21139-21140 SO_EXT:normal_or_wild_type_or_present denotes +
T13656 21142-21143 SO_EXT:normal_or_wild_type_or_present denotes +
T13657 21144-21145 SO_EXT:sequence_nullness_or_absence denotes -
T13658 21150-21151 SO_EXT:sequence_nullness_or_absence denotes -
T13659 21152-21153 SO_EXT:sequence_nullness_or_absence denotes -
T13660 21201-21210 CHEBI_EXT:poly_methyl_methacrylate denotes Plexiglas
T14346 21305-21310 CHEBI:15377 denotes Water
T14347 21329-21337 GO:0007612 denotes learning
T14348 21383-21388 CHEBI:15377 denotes water
T14349 21416-21420 NCBITaxon:10088 denotes mice
T14350 21606-21613 CHEBI_EXT:acrylic denotes acrylic
T14351 21683-21688 CHEBI:15377 denotes water
T14352 21763-21768 NCBITaxon:10088 denotes mouse
T14353 21784-21788 GO:0036268 denotes swim
T14354 22032-22038 NCBITaxon:33208 denotes animal
T14355 22227-22235 GO_EXT:biological_movement_or_translocation_process denotes movement
T14356 22244-22249 NCBITaxon:10088 denotes mouse
T14357 22364-22369 NCBITaxon:10088 denotes mouse
T14358 22436-22440 GO:0036268 denotes swim
T14359 22453-22457 GO:0036268 denotes Swim
T14360 22659-22664 NCBITaxon:10088 denotes mouse
T14361 22714-22719 NCBITaxon:10088 denotes mouse
T14362 22735-22739 GO:0036268 denotes swim
T14363 22904-22910 NCBITaxon:33208 denotes animal
T14921 22969-22974 GO_EXT:biological_movement_or_translocation_process denotes Motor
T14922 23205-23209 NCBITaxon:10088 denotes mice
T14923 23473-23479 NCBITaxon:33208 denotes animal
T15159 23544-23549 NCBITaxon:10088 denotes mouse
T15160 23629-23634 NCBITaxon:10088 denotes mouse
T15161 23695-23703 UBERON_EXT:forepaw denotes forepaws
T15162 23738-23742 UBERON:0002415 denotes tail
T15163 23771-23778 GO_EXT:biological_release denotes release
T15480 23817-23822 NCBITaxon:10088 denotes mouse
T15481 24148-24156 UBERON_EXT:forepaw denotes forepaws
T15482 24242-24250 UBERON_EXT:forepaw denotes forepaws
T15483 24267-24276 UBERON_EXT:hindpaw denotes hind paws
T15484 24313-24317 UBERON_EXT:paw denotes paws
T15485 24323-24327 UBERON:0002415 denotes tail
T15702 24432-24441 UBERON_EXT:hindpaw denotes hind paws
T15703 24450-24455 NCBITaxon:10088 denotes mouse
T15704 24464-24468 NCBITaxon:10088 denotes mice
T15947 24940-24945 CHEBI:15377 denotes water
T15948 24957-24968 GO_PATO_EXT:biological_behavior denotes Behavioural
T16201 25156-25163 UBERON:0000479 denotes tissues
T16202 25178-25183 UBERON:0000955 denotes brain
T16203 25185-25196 UBERON:0002240 denotes spinal cord
T16204 25198-25203 UBERON:0000948 denotes heart
T16205 25205-25209 UBERON:0002048 denotes lung
T16206 25211-25216 UBERON:0002107 denotes liver
T16207 25218-25224 UBERON:0002113 denotes kidney
T16208 25226-25232 UBERON:0002106 denotes spleen
T16209 25237-25243 UBERON:0000473 denotes testis
T16210 25249-25253 NCBITaxon:10088 denotes mice
T16211 25255-25256 SO_EXT:normal_or_wild_type_or_present denotes +
T16212 25257-25258 SO_EXT:normal_or_wild_type_or_present denotes +
T16213 25260-25261 SO_EXT:normal_or_wild_type_or_present denotes +
T16214 25262-25263 SO_EXT:sequence_nullness_or_absence denotes -
T16215 25268-25269 SO_EXT:sequence_nullness_or_absence denotes -
T16216 25270-25271 SO_EXT:sequence_nullness_or_absence denotes -
T16217 25321-25329 CHEBI_CHMO_EXT:buffer_process denotes buffered
T16218 25330-25338 CHEBI:16842 denotes formalin
T16219 25418-25429 CHEBI:51686 denotes hematoxylin
T16220 25434-25439 CHEBI_EXT:eosin denotes eosin
T9823 12704-12708 NCBITaxon:10088 denotes mice
T9908 15373-15379 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T9909 15373-15402 PR_EXT:000001023 denotes neural cell adhesion molecule
T9910 15380-15384 CL_GO_EXT:cell denotes cell
T9911 15385-15393 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T9912 15394-15402 CHEBI:36357 denotes molecule
T9913 15404-15408 PR_EXT:000001023 denotes NCAM
T9914 15438-15442 CL_GO_EXT:cell denotes cell
T9915 15463-15477 UBERON:0001016 denotes nervous system
T9916 15463-15489 GO:0007399 denotes nervous system development
T9917 15541-15549 GO:0045202 denotes synaptic
T9918 15568-15573 UBERON:0007023 denotes adult
T9919 15574-15588 UBERON:0001016 denotes nervous system
T9920 15606-15612 CL:0000540 denotes neuron
R2 T553 T552 _lexicallyChainedTo differentiation,cell
R221 T2147 T2146 _lexicallyChainedTo differentiation,cell
R2194 T9838 T9837 _lexicallyChainedTo IV,synaptotagmin
R2195 T9838 T9839 _lexicallyChainedTo IV,Syt
R2196 T9862 T9861 _lexicallyChainedTo conditioning,classical
R2197 T9885 T9884 _lexicallyChainedTo fields,CA1
R2198 T9931 T9930 _lexicallyChainedTo subunits,NR2A
R3638 T12281 T12280 _lexicallyChainedTo cells,embryonic stem
R3639 T12281 T12282 _lexicallyChainedTo cells,ES

craft-sa-dev

Id Subject Object Predicate Lexical cue
T565 0-8 NNS denotes Deficits
T566 0-76 sentence denotes Deficits in spatial learning and motor coordination in ADAM11-deficient mice
T567 9-11 IN denotes in
T568 12-19 JJ denotes spatial
T569 20-28 NN denotes learning
T570 29-32 CC denotes and
T571 33-38 NN denotes motor
T573 52-54 IN denotes in
T574 55-61 NN denotes ADAM11
T575 62-71 JJ denotes deficient
T576 61-62 HYPH denotes -
T577 72-76 NNS denotes mice
T578 76-77 sentence denotes
T579 87-97 sentence denotes Background
T580 87-97 NN denotes Background
T581 97-187 sentence denotes ADAM11 is a member of the ADAM gene family and is mainly expressed in the nervous system.
T582 98-104 NN denotes ADAM11
T583 105-107 VBZ denotes is
T584 108-109 DT denotes a
T585 110-116 NN denotes member
T586 117-119 IN denotes of
T587 120-123 DT denotes the
T588 134-140 NN denotes family
T589 124-128 NN denotes ADAM
T590 129-133 NN denotes gene
T591 141-144 CC denotes and
T592 145-147 VBZ denotes is
T593 155-164 VBN denotes expressed
T594 148-154 RB denotes mainly
T595 165-167 IN denotes in
T596 168-171 DT denotes the
T597 180-186 NN denotes system
T598 172-179 JJ denotes nervous
T599 186-187 . denotes .
T600 187-318 sentence denotes It is thought to be an adhesion molecule, since it has a disintegrin-like domain related to cell-cell or cell-matrix interactions.
T601 188-190 PRP denotes It
T602 194-201 VBN denotes thought
T603 191-193 VBZ denotes is
T604 202-204 TO denotes to
T605 205-207 VB denotes be
T606 208-210 DT denotes an
T607 220-228 NN denotes molecule
T608 211-219 NN denotes adhesion
T609 228-230 , denotes ,
T610 230-235 IN denotes since
T611 239-242 VBZ denotes has
T612 236-238 PRP denotes it
T613 243-244 DT denotes a
T614 262-268 NN denotes domain
T615 245-256 NN denotes disintegrin
T616 257-261 JJ denotes like
T617 256-257 HYPH denotes -
T618 269-276 VBN denotes related
T619 277-279 IN denotes to
T620 280-284 NN denotes cell
T621 285-289 NN denotes cell
T622 284-285 SYM denotes -
T623 305-317 NNS denotes interactions
T624 290-292 CC denotes or
T625 293-297 NN denotes cell
T626 298-304 NN denotes matrix
T627 297-298 SYM denotes -
T628 317-318 . denotes .
T629 318-433 sentence denotes To elucidate the physiological functions of ADAM11, we generated ADAM11-deficient mice by means of gene targeting.
T630 319-321 TO denotes To
T631 322-331 VB denotes elucidate
T632 374-383 VBD denotes generated
T633 332-335 DT denotes the
T634 350-359 NNS denotes functions
T635 336-349 JJ denotes physiological
T636 360-362 IN denotes of
T637 363-369 NN denotes ADAM11
T638 369-371 , denotes ,
T639 371-373 PRP denotes we
T640 384-390 NN denotes ADAM11
T641 391-400 JJ denotes deficient
T642 390-391 HYPH denotes -
T643 401-405 NNS denotes mice
T644 406-408 IN denotes by
T645 409-414 NNS denotes means
T646 415-417 IN denotes of
T647 418-422 NN denotes gene
T648 423-432 NN denotes targeting
T649 432-433 . denotes .
T650 433-442 sentence denotes Results
T651 435-442 NNS denotes Results
T652 442-590 sentence denotes ADAM11-deficient mice were apparently normal, and survived more than one year with no major histological abnormalities in the brain or spinal cord.
T653 443-449 NN denotes ADAM11
T654 450-459 JJ denotes deficient
T655 449-450 HYPH denotes -
T656 460-464 NNS denotes mice
T657 465-469 VBD denotes were
T658 470-480 RB denotes apparently
T659 481-487 JJ denotes normal
T660 487-489 , denotes ,
T661 489-492 CC denotes and
T662 493-501 VBD denotes survived
T663 502-506 JJR denotes more
T664 512-515 CD denotes one
T665 507-511 IN denotes than
T666 516-520 NN denotes year
T667 521-525 IN denotes with
T668 526-528 DT denotes no
T669 548-561 NNS denotes abnormalities
T670 529-534 JJ denotes major
T671 535-547 JJ denotes histological
T672 562-564 IN denotes in
T673 565-568 DT denotes the
T674 569-574 NN denotes brain
T675 575-577 CC denotes or
T676 578-584 JJ denotes spinal
T677 585-589 NN denotes cord
T678 589-590 . denotes .
T679 590-807 sentence denotes Because ADAM11 is highly expressed in the hippocampus and cerebellum, we have examined ADAM11 mutant mice for learning using visual and hidden water maze tasks, and their motor coordination using a rotating rod task.
T680 591-598 IN denotes Because
T681 606-608 VBZ denotes is
T682 599-605 NN denotes ADAM11
T683 669-677 VBN denotes examined
T684 609-615 RB denotes highly
T685 616-625 VBN denotes expressed
T686 626-628 IN denotes in
T687 629-632 DT denotes the
T688 633-644 NN denotes hippocampus
T689 645-648 CC denotes and
T690 649-659 NN denotes cerebellum
T691 659-661 , denotes ,
T692 661-663 PRP denotes we
T693 664-668 VBP denotes have
T694 678-684 NN denotes ADAM11
T695 692-696 NNS denotes mice
T696 685-691 NN denotes mutant
T697 697-700 IN denotes for
T698 701-709 VBG denotes learning
T699 710-715 VBG denotes using
T700 716-722 JJ denotes visual
T701 745-750 NNS denotes tasks
T702 723-726 CC denotes and
T703 727-733 JJ denotes hidden
T704 734-739 NN denotes water
T705 740-744 NN denotes maze
T706 750-752 , denotes ,
T707 752-755 CC denotes and
T708 756-761 PRP$ denotes their
T709 768-780 NN denotes coordination
T710 762-767 JJ denotes motor
T711 781-786 VBG denotes using
T712 787-788 DT denotes a
T713 802-806 NN denotes task
T714 789-797 VBG denotes rotating
T715 798-801 NN denotes rod
T716 806-807 . denotes .
T717 807-974 sentence denotes Our results showed that their visual water maze task results are normal, but the hidden water maze and rotating rod task skills are impaired in ADAM11-deficient mice.
T718 808-811 PRP$ denotes Our
T719 812-819 NNS denotes results
T720 820-826 VBD denotes showed
T721 827-831 IN denotes that
T722 869-872 VBP denotes are
T723 832-837 PRP$ denotes their
T724 861-868 NNS denotes results
T725 838-844 JJ denotes visual
T726 851-855 NN denotes maze
T727 845-850 NN denotes water
T728 856-860 NN denotes task
T729 873-879 JJ denotes normal
T730 879-881 , denotes ,
T731 881-884 CC denotes but
T732 885-888 DT denotes the
T733 929-935 NNS denotes skills
T734 889-895 JJ denotes hidden
T735 902-906 NN denotes maze
T736 896-901 NN denotes water
T737 924-928 NN denotes task
T738 907-910 CC denotes and
T739 911-919 VBG denotes rotating
T740 920-923 NN denotes rod
T741 936-939 VBP denotes are
T742 940-948 JJ denotes impaired
T743 949-951 IN denotes in
T744 952-958 NN denotes ADAM11
T745 959-968 JJ denotes deficient
T746 958-959 HYPH denotes -
T747 969-973 NNS denotes mice
T748 973-974 . denotes .
T749 974-986 sentence denotes Conclusion
T750 976-986 NN denotes Conclusion
T751 986-1144 sentence denotes Our results indicate that ADAM11 mutation does not affect cell migration and differentiation during development, but affects learning and motor coordination.
T752 987-990 PRP$ denotes Our
T753 991-998 NNS denotes results
T754 999-1007 VBP denotes indicate
T755 1008-1012 IN denotes that
T756 1038-1044 VB denotes affect
T757 1013-1019 NN denotes ADAM11
T758 1020-1028 NN denotes mutation
T759 1029-1033 VBZ denotes does
T760 1034-1037 RB denotes not
T761 1045-1049 NN denotes cell
T762 1050-1059 NN denotes migration
T763 1060-1063 CC denotes and
T764 1064-1079 NN denotes differentiation
T765 1080-1086 IN denotes during
T766 1087-1098 NN denotes development
T767 1098-1100 , denotes ,
T768 1100-1103 CC denotes but
T769 1104-1111 VBZ denotes affects
T770 1112-1120 NN denotes learning
T771 1121-1124 CC denotes and
T772 1125-1130 NN denotes motor
T773 1131-1143 NN denotes coordination
T774 1143-1144 . denotes .
T775 1144-1335 sentence denotes Thus, ADAM11 might play an important signalling or structural role as a cell adhesion molecule at the synapse, and may thus participate in synaptic regulation underlying behavioural changes.
T776 1145-1149 RB denotes Thus
T777 1164-1168 VB denotes play
T778 1149-1151 , denotes ,
T779 1151-1157 NN denotes ADAM11
T780 1158-1163 MD denotes might
T781 1169-1171 DT denotes an
T782 1207-1211 NN denotes role
T783 1172-1181 JJ denotes important
T784 1182-1192 NN denotes signalling
T785 1193-1195 CC denotes or
T786 1196-1206 JJ denotes structural
T787 1212-1214 IN denotes as
T788 1215-1216 DT denotes a
T789 1231-1239 NN denotes molecule
T790 1217-1221 NN denotes cell
T791 1222-1230 NN denotes adhesion
T792 1240-1242 IN denotes at
T793 1243-1246 DT denotes the
T794 1247-1254 NN denotes synapse
T795 1254-1256 , denotes ,
T796 1256-1259 CC denotes and
T797 1260-1263 MD denotes may
T798 1269-1280 VB denotes participate
T799 1264-1268 RB denotes thus
T800 1281-1283 IN denotes in
T801 1284-1292 JJ denotes synaptic
T802 1293-1303 NN denotes regulation
T803 1304-1314 VBG denotes underlying
T804 1315-1326 JJ denotes behavioural
T805 1327-1334 NNS denotes changes
T806 1334-1335 . denotes .
T2208 1348-1351 DT denotes The
T2209 1393-1399 NN denotes family
T2210 1352-1356 NN denotes ADAM
T2211 1357-1358 -LRB- denotes (
T2212 1358-1359 DT denotes A
T2213 1360-1371 NN denotes Disintegrin
T2214 1372-1375 CC denotes And
T2215 1376-1391 NN denotes Metalloprotease
T2216 1391-1392 -RRB- denotes )
T2217 1400-1409 VBZ denotes comprises
T2218 1410-1418 NN denotes membrane
T2219 1419-1427 VBG denotes spanning
T2220 1418-1419 HYPH denotes -
T2221 1441-1449 NN denotes proteins
T2222 1428-1440 JJ denotes multi-domain
T2223 1450-1460 VBG denotes containing
T2224 1461-1462 DT denotes a
T2225 1486-1492 NN denotes domain
T2226 1463-1480 NN denotes metalloproteinase
T2227 1481-1485 JJ denotes like
T2228 1480-1481 HYPH denotes -
T2229 1493-1496 CC denotes and
T2230 1497-1498 DT denotes a
T2231 1516-1522 NN denotes domain
T2232 1499-1510 NN denotes disintegrin
T2233 1511-1515 JJ denotes like
T2234 1510-1511 HYPH denotes -
T2235 1522-1523 . denotes .
T2236 1523-1708 sentence denotes Approximately half of the ADAMs are catalytically active metalloproteases that shed a broad range of substrates, such as cytokines, growth factors, receptors, adhesion molecules [1,2].
T2237 1524-1537 RB denotes Approximately
T2238 1538-1542 NN denotes half
T2239 1556-1559 VBP denotes are
T2240 1543-1545 IN denotes of
T2241 1546-1549 DT denotes the
T2242 1550-1555 NNS denotes ADAMs
T2243 1560-1573 RB denotes catalytically
T2244 1574-1580 JJ denotes active
T2245 1581-1597 NNS denotes metalloproteases
T2246 1598-1602 WDT denotes that
T2247 1603-1607 VBD denotes shed
T2248 1608-1609 DT denotes a
T2249 1616-1621 NN denotes range
T2250 1610-1615 JJ denotes broad
T2251 1622-1624 IN denotes of
T2252 1625-1635 NNS denotes substrates
T2253 1635-1637 , denotes ,
T2254 1637-1641 JJ denotes such
T2255 1642-1644 IN denotes as
T2256 1645-1654 NNS denotes cytokines
T2257 1654-1656 , denotes ,
T2258 1656-1662 NN denotes growth
T2259 1663-1670 NNS denotes factors
T2260 1670-1672 , denotes ,
T2261 1672-1681 NNS denotes receptors
T2262 1681-1683 , denotes ,
T2263 1683-1691 NN denotes adhesion
T2264 1692-1701 NNS denotes molecules
T2265 1702-1703 -LRB- denotes [
T2266 1705-1706 CD denotes 2
T2267 1703-1704 CD denotes 1
T2268 1704-1705 , denotes ,
T2269 1706-1707 -RRB- denotes ]
T2270 1707-1708 . denotes .
T2271 1708-1797 sentence denotes Recent gene-disruption studies in mice have disclosed a physiological role of each ADAM.
T2272 1709-1715 JJ denotes Recent
T2273 1732-1739 NNS denotes studies
T2274 1716-1720 NN denotes gene
T2275 1721-1731 NN denotes disruption
T2276 1720-1721 HYPH denotes -
T2277 1753-1762 VBN denotes disclosed
T2278 1740-1742 IN denotes in
T2279 1743-1747 NNS denotes mice
T2280 1748-1752 VBP denotes have
T2281 1763-1764 DT denotes a
T2282 1779-1783 NN denotes role
T2283 1765-1778 JJ denotes physiological
T2284 1784-1786 IN denotes of
T2285 1787-1791 DT denotes each
T2286 1792-1796 NN denotes ADAM
T2287 1796-1797 . denotes .
T2288 1797-1939 sentence denotes For example, ADAM10, ADAM17 and ADAM19 are critical for normal development by providing growth signals at the correct times and places [3-6].
T2289 1798-1801 IN denotes For
T2290 1837-1840 VBP denotes are
T2291 1802-1809 NN denotes example
T2292 1809-1811 , denotes ,
T2293 1811-1817 NN denotes ADAM10
T2294 1817-1819 , denotes ,
T2295 1819-1825 NN denotes ADAM17
T2296 1826-1829 CC denotes and
T2297 1830-1836 NN denotes ADAM19
T2298 1841-1849 JJ denotes critical
T2299 1850-1853 IN denotes for
T2300 1854-1860 JJ denotes normal
T2301 1861-1872 NN denotes development
T2302 1873-1875 IN denotes by
T2303 1876-1885 VBG denotes providing
T2304 1886-1892 NN denotes growth
T2305 1893-1900 NNS denotes signals
T2306 1901-1903 IN denotes at
T2307 1904-1907 DT denotes the
T2308 1916-1921 NNS denotes times
T2309 1908-1915 JJ denotes correct
T2310 1922-1925 CC denotes and
T2311 1926-1932 NNS denotes places
T2312 1933-1934 -LRB- denotes [
T2313 1934-1935 CD denotes 3
T2314 1935-1936 SYM denotes -
T2315 1936-1937 CD denotes 6
T2316 1937-1938 -RRB- denotes ]
T2317 1938-1939 . denotes .
T2318 1939-2110 sentence denotes In contrast, the functions of ADAM8, ADAM9, ADAM12 and ADAM15 are not essential for embryogenesis, suggesting a possible functional redundancy with other protease [7-10].
T2319 1940-1942 IN denotes In
T2320 2002-2005 VBP denotes are
T2321 1943-1951 NN denotes contrast
T2322 1951-1953 , denotes ,
T2323 1953-1956 DT denotes the
T2324 1957-1966 NNS denotes functions
T2325 1967-1969 IN denotes of
T2326 1970-1975 NN denotes ADAM8
T2327 1975-1977 , denotes ,
T2328 1977-1982 NN denotes ADAM9
T2329 1982-1984 , denotes ,
T2330 1984-1990 NN denotes ADAM12
T2331 1991-1994 CC denotes and
T2332 1995-2001 NN denotes ADAM15
T2333 2006-2009 RB denotes not
T2334 2010-2019 JJ denotes essential
T2335 2020-2023 IN denotes for
T2336 2024-2037 NN denotes embryogenesis
T2337 2037-2039 , denotes ,
T2338 2039-2049 VBG denotes suggesting
T2339 2050-2051 DT denotes a
T2340 2072-2082 NN denotes redundancy
T2341 2052-2060 JJ denotes possible
T2342 2061-2071 JJ denotes functional
T2343 2083-2087 IN denotes with
T2344 2088-2093 JJ denotes other
T2345 2094-2102 NN denotes protease
T2346 2103-2104 -LRB- denotes [
T2347 2104-2105 CD denotes 7
T2348 2105-2106 SYM denotes -
T2349 2106-2108 CD denotes 10
T2350 2108-2109 -RRB- denotes ]
T2351 2109-2110 . denotes .
T2352 2110-2198 sentence denotes The remaining half, which are non-protease-ADAMs, are thought to be adhesion molecules.
T2353 2111-2114 DT denotes The
T2354 2125-2129 NN denotes half
T2355 2115-2124 VBG denotes remaining
T2356 2165-2172 VBN denotes thought
T2357 2129-2131 , denotes ,
T2358 2131-2136 WDT denotes which
T2359 2137-2140 VBP denotes are
T2360 2141-2153 JJ denotes non-protease
T2361 2154-2159 NNS denotes ADAMs
T2362 2153-2154 HYPH denotes -
T2363 2159-2161 , denotes ,
T2364 2161-2164 VBP denotes are
T2365 2173-2175 TO denotes to
T2366 2176-2178 VB denotes be
T2367 2179-2187 NN denotes adhesion
T2368 2188-2197 NNS denotes molecules
T2369 2197-2198 . denotes .
T2370 2198-2292 sentence denotes More than ten ADAMs have been shown to support integrin-mediated cell adhesion in vitro [11].
T2371 2199-2203 JJR denotes More
T2372 2209-2212 CD denotes ten
T2373 2204-2208 IN denotes than
T2374 2213-2218 NNS denotes ADAMs
T2375 2229-2234 VBN denotes shown
T2376 2219-2223 VBP denotes have
T2377 2224-2228 VBN denotes been
T2378 2235-2237 TO denotes to
T2379 2238-2245 VB denotes support
T2380 2246-2254 NN denotes integrin
T2381 2255-2263 VBN denotes mediated
T2382 2254-2255 HYPH denotes -
T2383 2269-2277 NN denotes adhesion
T2384 2264-2268 NN denotes cell
T2385 2278-2280 FW denotes in
T2386 2281-2286 FW denotes vitro
T2387 2287-2288 -LRB- denotes [
T2388 2288-2290 CD denotes 11
T2389 2290-2291 -RRB- denotes ]
T2390 2291-2292 . denotes .
T2391 2292-2441 sentence denotes More recently, the finding has been reported that integrin-mediated cell migration of tissue culture cells can be controlled by distinct ADAMs [12].
T2392 2293-2297 RBR denotes More
T2393 2298-2306 RB denotes recently
T2394 2329-2337 VBN denotes reported
T2395 2306-2308 , denotes ,
T2396 2308-2311 DT denotes the
T2397 2312-2319 NN denotes finding
T2398 2320-2323 VBZ denotes has
T2399 2324-2328 VBN denotes been
T2400 2338-2342 IN denotes that
T2401 2407-2417 VBN denotes controlled
T2402 2343-2351 NN denotes integrin
T2403 2352-2360 VBN denotes mediated
T2404 2351-2352 HYPH denotes -
T2405 2366-2375 NN denotes migration
T2406 2361-2365 NN denotes cell
T2407 2376-2378 IN denotes of
T2408 2379-2385 NN denotes tissue
T2409 2386-2393 NN denotes culture
T2410 2394-2399 NNS denotes cells
T2411 2400-2403 MD denotes can
T2412 2404-2406 VB denotes be
T2413 2418-2420 IN denotes by
T2414 2421-2429 JJ denotes distinct
T2415 2430-2435 NNS denotes ADAMs
T2416 2436-2437 -LRB- denotes [
T2417 2437-2439 CD denotes 12
T2418 2439-2440 -RRB- denotes ]
T2419 2440-2441 . denotes .
T2420 2441-2573 sentence denotes In C. elegans, unc-71 gene coding a non-protease-ADAM protein have been shown to be involved in cell migration events in vivo [13].
T2421 2442-2444 IN denotes In
T2422 2514-2519 VBN denotes shown
T2423 2445-2447 NNP denotes C.
T2424 2448-2455 NNP denotes elegans
T2425 2455-2457 , denotes ,
T2426 2457-2460 NN denotes unc
T2427 2464-2468 NN denotes gene
T2428 2460-2461 HYPH denotes -
T2429 2461-2463 CD denotes 71
T2430 2469-2475 VBG denotes coding
T2431 2476-2477 DT denotes a
T2432 2496-2503 NN denotes protein
T2433 2478-2490 JJ denotes non-protease
T2434 2490-2491 HYPH denotes -
T2435 2491-2495 NN denotes ADAM
T2436 2504-2508 VBP denotes have
T2437 2509-2513 VBN denotes been
T2438 2520-2522 TO denotes to
T2439 2526-2534 VBN denotes involved
T2440 2523-2525 VB denotes be
T2441 2535-2537 IN denotes in
T2442 2538-2542 NN denotes cell
T2443 2543-2552 NN denotes migration
T2444 2553-2559 NNS denotes events
T2445 2560-2562 FW denotes in
T2446 2563-2567 FW denotes vivo
T2447 2568-2569 -LRB- denotes [
T2448 2569-2571 CD denotes 13
T2449 2571-2572 -RRB- denotes ]
T2450 2572-2573 . denotes .
T2451 2573-2669 sentence denotes However, the physiological roles of mammalian non-protease-ADAMs are poorly understood in vivo.
T2452 2574-2581 RB denotes However
T2453 2639-2642 VBP denotes are
T2454 2581-2583 , denotes ,
T2455 2583-2586 DT denotes the
T2456 2601-2606 NNS denotes roles
T2457 2587-2600 JJ denotes physiological
T2458 2607-2609 IN denotes of
T2459 2610-2619 JJ denotes mammalian
T2460 2633-2638 NNS denotes ADAMs
T2461 2620-2632 JJ denotes non-protease
T2462 2632-2633 HYPH denotes -
T2463 2643-2649 RB denotes poorly
T2464 2650-2660 VBN denotes understood
T2465 2661-2663 FW denotes in
T2466 2664-2668 FW denotes vivo
T2467 2668-2669 . denotes .
T2468 2669-2834 sentence denotes Genetic deletion studies in mice have shown that both Adam2-null and Adam3-null male mutants are infertile and their spermatozoa lack egg-binding abilities [14-16].
T2469 2670-2677 JJ denotes Genetic
T2470 2678-2686 NN denotes deletion
T2471 2687-2694 NNS denotes studies
T2472 2708-2713 VBN denotes shown
T2473 2695-2697 IN denotes in
T2474 2698-2702 NNS denotes mice
T2475 2703-2707 VBP denotes have
T2476 2714-2718 IN denotes that
T2477 2763-2766 VBP denotes are
T2478 2719-2723 CC denotes both
T2479 2755-2762 NNS denotes mutants
T2480 2724-2729 NN denotes Adam2
T2481 2730-2734 JJ denotes null
T2482 2729-2730 HYPH denotes -
T2483 2735-2738 CC denotes and
T2484 2739-2744 NN denotes Adam3
T2485 2745-2749 JJ denotes null
T2486 2744-2745 HYPH denotes -
T2487 2750-2754 JJ denotes male
T2488 2767-2776 JJ denotes infertile
T2489 2777-2780 CC denotes and
T2490 2781-2786 PRP$ denotes their
T2491 2787-2798 NNS denotes spermatozoa
T2492 2799-2803 VBP denotes lack
T2493 2804-2807 NN denotes egg
T2494 2816-2825 NNS denotes abilities
T2495 2807-2808 HYPH denotes -
T2496 2808-2815 VBG denotes binding
T2497 2826-2827 -LRB- denotes [
T2498 2827-2829 CD denotes 14
T2499 2829-2830 SYM denotes -
T2500 2830-2832 CD denotes 16
T2501 2832-2833 -RRB- denotes ]
T2502 2833-2834 . denotes .
T2503 2834-2885 sentence denotes The precise mechanism is under investigation [17].
T2504 2835-2838 DT denotes The
T2505 2847-2856 NN denotes mechanism
T2506 2839-2846 JJ denotes precise
T2507 2857-2859 VBZ denotes is
T2508 2860-2865 IN denotes under
T2509 2866-2879 NN denotes investigation
T2510 2880-2881 -LRB- denotes [
T2511 2881-2883 CD denotes 17
T2512 2883-2884 -RRB- denotes ]
T2513 2884-2885 . denotes .
T2514 2885-3031 sentence denotes We have reported the findings of ADAM11, ADAM22 and ADAM23 genes and their restricted expression in the human and murine nervous systems [18,19].
T2515 2886-2888 PRP denotes We
T2516 2894-2902 VBN denotes reported
T2517 2889-2893 VBP denotes have
T2518 2903-2906 DT denotes the
T2519 2907-2915 NNS denotes findings
T2520 2916-2918 IN denotes of
T2521 2919-2925 NN denotes ADAM11
T2522 2945-2950 NNS denotes genes
T2523 2925-2927 , denotes ,
T2524 2927-2933 NN denotes ADAM22
T2525 2934-2937 CC denotes and
T2526 2938-2944 NN denotes ADAM23
T2527 2951-2954 CC denotes and
T2528 2955-2960 PRP$ denotes their
T2529 2972-2982 NN denotes expression
T2530 2961-2971 VBN denotes restricted
T2531 2983-2985 IN denotes in
T2532 2986-2989 DT denotes the
T2533 3015-3022 NNS denotes systems
T2534 2990-2995 JJ denotes human
T2535 2996-2999 CC denotes and
T2536 3000-3006 JJ denotes murine
T2537 3007-3014 JJ denotes nervous
T2538 3023-3024 -LRB- denotes [
T2539 3027-3029 CD denotes 19
T2540 3024-3026 CD denotes 18
T2541 3026-3027 , denotes ,
T2542 3029-3030 -RRB- denotes ]
T2543 3030-3031 . denotes .
T2544 3031-3151 sentence denotes These ADAMs lack a catalytic motif critical for the metalloproteinase activity, suggesting that they are not proteases.
T2545 3032-3037 DT denotes These
T2546 3038-3043 NNS denotes ADAMs
T2547 3044-3048 VBP denotes lack
T2548 3049-3050 DT denotes a
T2549 3061-3066 NN denotes motif
T2550 3051-3060 JJ denotes catalytic
T2551 3067-3075 JJ denotes critical
T2552 3076-3079 IN denotes for
T2553 3080-3083 DT denotes the
T2554 3102-3110 NN denotes activity
T2555 3084-3101 NN denotes metalloproteinase
T2556 3110-3112 , denotes ,
T2557 3112-3122 VBG denotes suggesting
T2558 3123-3127 IN denotes that
T2559 3133-3136 VBP denotes are
T2560 3128-3132 PRP denotes they
T2561 3137-3140 RB denotes not
T2562 3141-3150 NNS denotes proteases
T2563 3150-3151 . denotes .
T2564 3151-3360 sentence denotes We assume that these ADAMs might contribute to cell migration, differentiation and survival or synaptic regulation by binding to integrins, cell-surface proteins or intracellular signalling molecules [20,21].
T2565 3152-3154 PRP denotes We
T2566 3155-3161 VBP denotes assume
T2567 3162-3166 IN denotes that
T2568 3185-3195 VB denotes contribute
T2569 3167-3172 DT denotes these
T2570 3173-3178 NNS denotes ADAMs
T2571 3179-3184 MD denotes might
T2572 3196-3198 IN denotes to
T2573 3199-3203 NN denotes cell
T2574 3204-3213 NN denotes migration
T2575 3213-3215 , denotes ,
T2576 3215-3230 NN denotes differentiation
T2577 3231-3234 CC denotes and
T2578 3235-3243 NN denotes survival
T2579 3244-3246 CC denotes or
T2580 3247-3255 JJ denotes synaptic
T2581 3256-3266 NN denotes regulation
T2582 3267-3269 IN denotes by
T2583 3270-3277 VBG denotes binding
T2584 3278-3280 IN denotes to
T2585 3281-3290 NNS denotes integrins
T2586 3290-3292 , denotes ,
T2587 3292-3296 NN denotes cell
T2588 3297-3304 NN denotes surface
T2589 3296-3297 HYPH denotes -
T2590 3305-3313 NN denotes proteins
T2591 3314-3316 CC denotes or
T2592 3317-3330 JJ denotes intracellular
T2593 3342-3351 NNS denotes molecules
T2594 3331-3341 NN denotes signalling
T2595 3352-3353 -LRB- denotes [
T2596 3356-3358 CD denotes 21
T2597 3353-3355 CD denotes 20
T2598 3355-3356 , denotes ,
T2599 3358-3359 -RRB- denotes ]
T2600 3359-3360 . denotes .
T2601 3360-3527 sentence denotes We have reported severe ataxia, seizures, and death before weaning, accompanied with hypomyelination of the peripheral nervous system in Adam22-null mutant mice [22].
T2602 3361-3363 PRP denotes We
T2603 3369-3377 VBN denotes reported
T2604 3364-3368 VBP denotes have
T2605 3378-3384 JJ denotes severe
T2606 3385-3391 NN denotes ataxia
T2607 3391-3393 , denotes ,
T2608 3393-3401 NNS denotes seizures
T2609 3401-3403 , denotes ,
T2610 3403-3406 CC denotes and
T2611 3407-3412 NN denotes death
T2612 3413-3419 IN denotes before
T2613 3420-3427 NN denotes weaning
T2614 3427-3429 , denotes ,
T2615 3429-3440 VBN denotes accompanied
T2616 3441-3445 IN denotes with
T2617 3446-3461 NN denotes hypomyelination
T2618 3462-3464 IN denotes of
T2619 3465-3468 DT denotes the
T2620 3488-3494 NN denotes system
T2621 3469-3479 JJ denotes peripheral
T2622 3480-3487 JJ denotes nervous
T2623 3495-3497 IN denotes in
T2624 3498-3504 NN denotes Adam22
T2625 3505-3509 JJ denotes null
T2626 3504-3505 HYPH denotes -
T2627 3517-3521 NNS denotes mice
T2628 3510-3516 NN denotes mutant
T2629 3522-3523 -LRB- denotes [
T2630 3523-3525 CD denotes 22
T2631 3525-3526 -RRB- denotes ]
T2632 3526-3527 . denotes .
T2633 3527-3663 sentence denotes It has been reported that the disruption of Adam23 gene in the mouse results in premature death associated with ataxia and tremor [23].
T2634 3528-3530 PRP denotes It
T2635 3540-3548 VBN denotes reported
T2636 3531-3534 VBZ denotes has
T2637 3535-3539 VBN denotes been
T2638 3549-3553 IN denotes that
T2639 3597-3604 VBZ denotes results
T2640 3554-3557 DT denotes the
T2641 3558-3568 NN denotes disruption
T2642 3569-3571 IN denotes of
T2643 3572-3578 NN denotes Adam23
T2644 3579-3583 NN denotes gene
T2645 3584-3586 IN denotes in
T2646 3587-3590 DT denotes the
T2647 3591-3596 NN denotes mouse
T2648 3605-3607 IN denotes in
T2649 3608-3617 JJ denotes premature
T2650 3618-3623 NN denotes death
T2651 3624-3634 VBN denotes associated
T2652 3635-3639 IN denotes with
T2653 3640-3646 NN denotes ataxia
T2654 3647-3650 CC denotes and
T2655 3651-3657 NN denotes tremor
T2656 3658-3659 -LRB- denotes [
T2657 3659-3661 CD denotes 23
T2658 3661-3662 -RRB- denotes ]
T2659 3662-3663 . denotes .
T2660 3663-3799 sentence denotes Is spite of such extreme phenotypes, no histological defects in the brain has been observed in either Adam22-null nor Adam23-null mice.
T2661 3664-3666 IN denotes Is
T2662 3747-3755 VBN denotes observed
T2663 3667-3672 NN denotes spite
T2664 3673-3675 IN denotes of
T2665 3676-3680 JJ denotes such
T2666 3689-3699 NNS denotes phenotypes
T2667 3681-3688 JJ denotes extreme
T2668 3699-3701 , denotes ,
T2669 3701-3703 DT denotes no
T2670 3717-3724 NNS denotes defects
T2671 3704-3716 JJ denotes histological
T2672 3725-3727 IN denotes in
T2673 3728-3731 DT denotes the
T2674 3732-3737 NN denotes brain
T2675 3738-3741 VBZ denotes has
T2676 3742-3746 VBN denotes been
T2677 3756-3758 IN denotes in
T2678 3759-3765 CC denotes either
T2679 3794-3798 NNS denotes mice
T2680 3766-3772 NN denotes Adam22
T2681 3773-3777 JJ denotes null
T2682 3772-3773 HYPH denotes -
T2683 3778-3781 CC denotes nor
T2684 3782-3788 NN denotes Adam23
T2685 3789-3793 JJ denotes null
T2686 3788-3789 HYPH denotes -
T2687 3798-3799 . denotes .
T2688 3799-3927 sentence denotes ADAM11 is the closest paralog of ADAM22 and ADAM23, and its orthologs have been found in vertebrates, but not in invertebrates.
T2689 3800-3806 NN denotes ADAM11
T2690 3807-3809 VBZ denotes is
T2691 3810-3813 DT denotes the
T2692 3822-3829 NN denotes paralog
T2693 3814-3821 JJS denotes closest
T2694 3830-3832 IN denotes of
T2695 3833-3839 NN denotes ADAM22
T2696 3840-3843 CC denotes and
T2697 3844-3850 NN denotes ADAM23
T2698 3850-3852 , denotes ,
T2699 3852-3855 CC denotes and
T2700 3856-3859 PRP$ denotes its
T2701 3860-3869 NNS denotes orthologs
T2702 3880-3885 VBN denotes found
T2703 3870-3874 VBP denotes have
T2704 3875-3879 VBN denotes been
T2705 3886-3888 IN denotes in
T2706 3889-3900 NNS denotes vertebrates
T2707 3900-3902 , denotes ,
T2708 3902-3905 CC denotes but
T2709 3906-3909 RB denotes not
T2710 3910-3912 IN denotes in
T2711 3913-3926 NNS denotes invertebrates
T2712 3926-3927 . denotes .
T2713 3927-4287 sentence denotes It has been reported that the Xenopus ADAM11 ortholog, xMDC11a, has an expression pattern associated with neural development, with a proposed role in cell migration [24]; and it has been reported in analyses using Northern blot and in situ hybridisation methods that the murine Adam11 gene is expressed in both the developing and adult nervous system [19,25].
T2714 3928-3930 PRP denotes It
T2715 3940-3948 VBN denotes reported
T2716 3931-3934 VBZ denotes has
T2717 3935-3939 VBN denotes been
T2718 3949-3953 IN denotes that
T2719 3992-3995 VBZ denotes has
T2720 3954-3957 DT denotes the
T2721 3973-3981 NN denotes ortholog
T2722 3958-3965 NNP denotes Xenopus
T2723 3966-3972 NN denotes ADAM11
T2724 3981-3983 , denotes ,
T2725 3983-3990 NN denotes xMDC11a
T2726 3990-3992 , denotes ,
T2727 3996-3998 DT denotes an
T2728 4010-4017 NN denotes pattern
T2729 3999-4009 NN denotes expression
T2730 4018-4028 VBN denotes associated
T2731 4029-4033 IN denotes with
T2732 4034-4040 JJ denotes neural
T2733 4041-4052 NN denotes development
T2734 4052-4054 , denotes ,
T2735 4054-4058 IN denotes with
T2736 4059-4060 DT denotes a
T2737 4070-4074 NN denotes role
T2738 4061-4069 VBN denotes proposed
T2739 4075-4077 IN denotes in
T2740 4078-4082 NN denotes cell
T2741 4083-4092 NN denotes migration
T2742 4093-4094 -LRB- denotes [
T2743 4094-4096 CD denotes 24
T2744 4096-4097 -RRB- denotes ]
T2745 4097-4098 : denotes ;
T2746 4099-4102 CC denotes and
T2747 4103-4105 PRP denotes it
T2748 4115-4123 VBN denotes reported
T2749 4106-4109 VBZ denotes has
T2750 4110-4114 VBN denotes been
T2751 4124-4126 IN denotes in
T2752 4127-4135 NNS denotes analyses
T2753 4136-4141 VBG denotes using
T2754 4142-4150 NNP denotes Northern
T2755 4151-4155 NN denotes blot
T2756 4182-4189 NNS denotes methods
T2757 4156-4159 CC denotes and
T2758 4160-4162 FW denotes in
T2759 4163-4167 FW denotes situ
T2760 4168-4181 NN denotes hybridisation
T2761 4190-4194 IN denotes that
T2762 4221-4230 VBN denotes expressed
T2763 4195-4198 DT denotes the
T2764 4213-4217 NN denotes gene
T2765 4199-4205 JJ denotes murine
T2766 4206-4212 NN denotes Adam11
T2767 4218-4220 VBZ denotes is
T2768 4231-4233 IN denotes in
T2769 4234-4238 CC denotes both
T2770 4272-4278 NN denotes system
T2771 4239-4242 DT denotes the
T2772 4243-4253 VBG denotes developing
T2773 4254-4257 CC denotes and
T2774 4258-4263 JJ denotes adult
T2775 4264-4271 JJ denotes nervous
T2776 4279-4280 -LRB- denotes [
T2777 4283-4285 CD denotes 25
T2778 4280-4282 CD denotes 19
T2779 4282-4283 , denotes ,
T2780 4285-4286 -RRB- denotes ]
T2781 4286-4287 . denotes .
T2782 4287-4435 sentence denotes These findings led us to hypothesise that ADAM11 is an integrin binder that plays an important role in the nervous system, as do ADAM22 and ADAM23.
T2783 4288-4293 DT denotes These
T2784 4294-4302 NNS denotes findings
T2785 4303-4306 VBD denotes led
T2786 4307-4309 PRP denotes us
T2787 4310-4312 TO denotes to
T2788 4313-4324 VB denotes hypothesise
T2789 4325-4329 IN denotes that
T2790 4337-4339 VBZ denotes is
T2791 4330-4336 NN denotes ADAM11
T2792 4340-4342 DT denotes an
T2793 4352-4358 NN denotes binder
T2794 4343-4351 NN denotes integrin
T2795 4359-4363 WDT denotes that
T2796 4364-4369 VBZ denotes plays
T2797 4370-4372 DT denotes an
T2798 4383-4387 NN denotes role
T2799 4373-4382 JJ denotes important
T2800 4388-4390 IN denotes in
T2801 4391-4394 DT denotes the
T2802 4403-4409 NN denotes system
T2803 4395-4402 JJ denotes nervous
T2804 4409-4411 , denotes ,
T2805 4411-4413 IN denotes as
T2806 4414-4416 VBP denotes do
T2807 4417-4423 NN denotes ADAM22
T2808 4424-4427 CC denotes and
T2809 4428-4434 NN denotes ADAM23
T2810 4434-4435 . denotes .
T2811 4435-4540 sentence denotes To determine the physiological functions of ADAM11, we generated and analysed Adam11 gene-targeted mice.
T2812 4436-4438 TO denotes To
T2813 4439-4448 VB denotes determine
T2814 4491-4500 VBD denotes generated
T2815 4449-4452 DT denotes the
T2816 4467-4476 NNS denotes functions
T2817 4453-4466 JJ denotes physiological
T2818 4477-4479 IN denotes of
T2819 4480-4486 NN denotes ADAM11
T2820 4486-4488 , denotes ,
T2821 4488-4490 PRP denotes we
T2822 4501-4504 CC denotes and
T2823 4505-4513 VBD denotes analysed
T2824 4514-4520 NN denotes Adam11
T2825 4535-4539 NNS denotes mice
T2826 4521-4525 NN denotes gene
T2827 4526-4534 VBN denotes targeted
T2828 4525-4526 HYPH denotes -
T2829 4539-4540 . denotes .
T3287 4934-4936 VB denotes be
T3214 4551-4561 NN denotes Generation
T3215 4562-4564 IN denotes of
T3216 4565-4571 NN denotes ADAM11
T3217 4572-4581 JJ denotes deficient
T3218 4571-4572 HYPH denotes -
T3219 4582-4586 NNS denotes mice
T3220 4586-4695 sentence denotes Mice carrying a targeted mutation in their Adam11 gene were generated by homologous recombination (Fig. 1A).
T3221 4587-4591 NNS denotes Mice
T3222 4647-4656 VBN denotes generated
T3223 4592-4600 VBG denotes carrying
T3224 4601-4602 DT denotes a
T3225 4612-4620 NN denotes mutation
T3226 4603-4611 VBN denotes targeted
T3227 4621-4623 IN denotes in
T3228 4624-4629 PRP$ denotes their
T3229 4637-4641 NN denotes gene
T3230 4630-4636 NN denotes Adam11
T3231 4642-4646 VBD denotes were
T3232 4657-4659 IN denotes by
T3233 4660-4670 JJ denotes homologous
T3234 4671-4684 NN denotes recombination
T3235 4685-4686 -LRB- denotes (
T3236 4691-4693 NN denotes 1A
T3237 4686-4690 NN denotes Fig.
T3238 4693-4694 -RRB- denotes )
T3239 4694-4695 . denotes .
T3240 4695-4772 sentence denotes Correct targeting events were confirmed by Southern blot analysis (Fig. 1B).
T3241 4696-4703 JJ denotes Correct
T3242 4714-4720 NNS denotes events
T3243 4704-4713 NN denotes targeting
T3244 4726-4735 VBN denotes confirmed
T3245 4721-4725 VBD denotes were
T3246 4736-4738 IN denotes by
T3247 4739-4747 NNP denotes Southern
T3248 4748-4752 NN denotes blot
T3249 4753-4761 NN denotes analysis
T3250 4762-4763 -LRB- denotes (
T3251 4768-4770 NN denotes 1B
T3252 4763-4767 NN denotes Fig.
T3253 4770-4771 -RRB- denotes )
T3254 4771-4772 . denotes .
T3255 4772-4975 sentence denotes As a result of this procedure, since a termination codon was introduced in exon 5 in the pro-protein domain, only the truncated form of the ADAM11 protein would be synthesised from this targeted allele.
T3256 4773-4775 IN denotes As
T3257 4937-4948 VBN denotes synthesised
T3258 4776-4777 DT denotes a
T3259 4778-4784 NN denotes result
T3260 4785-4787 IN denotes of
T3261 4788-4792 DT denotes this
T3262 4793-4802 NN denotes procedure
T3263 4802-4804 , denotes ,
T3264 4804-4809 IN denotes since
T3265 4834-4844 VBN denotes introduced
T3266 4810-4811 DT denotes a
T3267 4824-4829 NN denotes codon
T3268 4812-4823 NN denotes termination
T3269 4830-4833 VBD denotes was
T3270 4845-4847 IN denotes in
T3271 4848-4852 NN denotes exon
T3272 4853-4854 CD denotes 5
T3273 4855-4857 IN denotes in
T3274 4858-4861 DT denotes the
T3275 4874-4880 NN denotes domain
T3276 4862-4873 JJ denotes pro-protein
T3277 4880-4882 , denotes ,
T3278 4882-4886 RB denotes only
T3279 4901-4905 NN denotes form
T3280 4887-4890 DT denotes the
T3281 4891-4900 VBN denotes truncated
T3282 4906-4908 IN denotes of
T3283 4909-4912 DT denotes the
T3284 4920-4927 NN denotes protein
T3285 4913-4919 NN denotes ADAM11
T3286 4928-4933 MD denotes would
T3288 4949-4953 IN denotes from
T3289 4954-4958 DT denotes this
T3290 4968-4974 NN denotes allele
T3291 4959-4967 VBN denotes targeted
T3292 4974-4975 . denotes .
T3293 4975-5209 sentence denotes Because pro-protein domains are always removed in mature functional ADAM-proteins by furin-like proteases and are thus thought to be non-functional, we concluded that this truncated form of ADAM11 protein would have no function [26].
T3294 4976-4983 IN denotes Because
T3295 5015-5022 VBN denotes removed
T3296 4984-4995 JJ denotes pro-protein
T3297 4996-5003 NNS denotes domains
T3298 5004-5007 VBP denotes are
T3299 5008-5014 RB denotes always
T3300 5128-5137 VBD denotes concluded
T3301 5023-5025 IN denotes in
T3302 5026-5032 JJ denotes mature
T3303 5049-5057 NN denotes proteins
T3304 5033-5043 JJ denotes functional
T3305 5044-5048 NN denotes ADAM
T3306 5048-5049 HYPH denotes -
T3307 5058-5060 IN denotes by
T3308 5061-5066 NN denotes furin
T3309 5067-5071 JJ denotes like
T3310 5066-5067 HYPH denotes -
T3311 5072-5081 NNS denotes proteases
T3312 5082-5085 CC denotes and
T3313 5086-5089 VBP denotes are
T3314 5095-5102 VBN denotes thought
T3315 5090-5094 RB denotes thus
T3316 5103-5105 TO denotes to
T3317 5106-5108 VB denotes be
T3318 5109-5123 JJ denotes non-functional
T3319 5123-5125 , denotes ,
T3320 5125-5127 PRP denotes we
T3321 5138-5142 IN denotes that
T3322 5187-5191 VB denotes have
T3323 5143-5147 DT denotes this
T3324 5158-5162 NN denotes form
T3325 5148-5157 VBN denotes truncated
T3326 5163-5165 IN denotes of
T3327 5166-5172 NN denotes ADAM11
T3328 5173-5180 NN denotes protein
T3329 5181-5186 MD denotes would
T3330 5192-5194 DT denotes no
T3331 5195-5203 NN denotes function
T3332 5204-5205 -LRB- denotes [
T3333 5205-5207 CD denotes 26
T3334 5207-5208 -RRB- denotes ]
T3335 5208-5209 . denotes .
T3336 5209-5375 sentence denotes Absence of mature ADAM11 protein in homozygous mutants was confirmed by Western blot analysis using a specific antibody that recognises the ADAM11 protein (Fig. 1C).
T3337 5210-5217 NN denotes Absence
T3338 5269-5278 VBN denotes confirmed
T3339 5218-5220 IN denotes of
T3340 5221-5227 JJ denotes mature
T3341 5235-5242 NN denotes protein
T3342 5228-5234 NN denotes ADAM11
T3343 5243-5245 IN denotes in
T3344 5246-5256 JJ denotes homozygous
T3345 5257-5264 NNS denotes mutants
T3346 5265-5268 VBD denotes was
T3347 5279-5281 IN denotes by
T3348 5282-5289 NNP denotes Western
T3349 5290-5294 NN denotes blot
T3350 5295-5303 NN denotes analysis
T3351 5304-5309 VBG denotes using
T3352 5310-5311 DT denotes a
T3353 5321-5329 NN denotes antibody
T3354 5312-5320 JJ denotes specific
T3355 5330-5334 WDT denotes that
T3356 5335-5345 VBZ denotes recognises
T3357 5346-5349 DT denotes the
T3358 5357-5364 NN denotes protein
T3359 5350-5356 NN denotes ADAM11
T3360 5365-5366 -LRB- denotes (
T3361 5371-5373 NN denotes 1C
T3362 5366-5370 NN denotes Fig.
T3363 5373-5374 -RRB- denotes )
T3364 5374-5375 . denotes .
T3365 5375-5504 sentence denotes Analysis by Western blot showed that heterozygous mutants produced approximately half of the wild-type levels of ADAM11 protein.
T3366 5376-5384 NN denotes Analysis
T3367 5401-5407 VBD denotes showed
T3368 5385-5387 IN denotes by
T3369 5388-5395 NNP denotes Western
T3370 5396-5400 NN denotes blot
T3371 5408-5412 IN denotes that
T3372 5434-5442 VBD denotes produced
T3373 5413-5425 JJ denotes heterozygous
T3374 5426-5433 NNS denotes mutants
T3375 5443-5456 RB denotes approximately
T3376 5457-5461 NN denotes half
T3377 5462-5464 IN denotes of
T3378 5465-5468 DT denotes the
T3379 5479-5485 NNS denotes levels
T3380 5469-5473 JJ denotes wild
T3381 5474-5478 NN denotes type
T3382 5473-5474 HYPH denotes -
T3383 5486-5488 IN denotes of
T3384 5489-5495 NN denotes ADAM11
T3385 5496-5503 NN denotes protein
T3386 5503-5504 . denotes .
T3987 5506-5512 NN denotes ADAM11
T3988 5513-5522 JJ denotes deficient
T3989 5512-5513 HYPH denotes -
T3990 5523-5527 NNS denotes mice
T3991 5528-5531 VBP denotes are
T3992 5532-5538 JJ denotes viable
T3993 5539-5542 CC denotes and
T3994 5543-5549 VB denotes appear
T3995 5550-5556 JJ denotes normal
T3996 5556-5756 sentence denotes Mating of mice heterozygous for the ADAM11 mutation yielded a near-Mendelian distribution of genotypes in the offspring and the ratio of females and males was the same in all groups (data not shown).
T3997 5557-5563 VBG denotes Mating
T3998 5609-5616 VBD denotes yielded
T3999 5564-5566 IN denotes of
T4000 5567-5571 NNS denotes mice
T4001 5572-5584 JJ denotes heterozygous
T4002 5585-5588 IN denotes for
T4003 5589-5592 DT denotes the
T4004 5600-5608 NN denotes mutation
T4005 5593-5599 NN denotes ADAM11
T4006 5617-5618 DT denotes a
T4007 5634-5646 NN denotes distribution
T4008 5619-5623 JJ denotes near
T4009 5624-5633 JJ denotes Mendelian
T4010 5623-5624 HYPH denotes -
T4011 5647-5649 IN denotes of
T4012 5650-5659 NNS denotes genotypes
T4013 5660-5662 IN denotes in
T4014 5663-5666 DT denotes the
T4015 5667-5676 NN denotes offspring
T4016 5677-5680 CC denotes and
T4017 5681-5684 DT denotes the
T4018 5685-5690 NN denotes ratio
T4019 5712-5715 VBD denotes was
T4020 5691-5693 IN denotes of
T4021 5694-5701 NNS denotes females
T4022 5702-5705 CC denotes and
T4023 5706-5711 NNS denotes males
T4024 5716-5719 DT denotes the
T4025 5720-5724 JJ denotes same
T4026 5725-5727 IN denotes in
T4027 5728-5731 DT denotes all
T4028 5732-5738 NNS denotes groups
T4029 5739-5740 -LRB- denotes (
T4030 5749-5754 VBN denotes shown
T4031 5740-5744 NNS denotes data
T4032 5745-5748 RB denotes not
T4033 5754-5755 -RRB- denotes )
T4034 5755-5756 . denotes .
T4035 5756-5938 sentence denotes For the present experiments, ADAM11-deficient male mice (backcrossed generations into C57BL/6NCrj, n = 14) were used in all behavioural analyses and anatomical-histological studies.
T4036 5757-5760 IN denotes For
T4037 5869-5873 VBN denotes used
T4038 5761-5764 DT denotes the
T4039 5773-5784 NNS denotes experiments
T4040 5765-5772 JJ denotes present
T4041 5784-5786 , denotes ,
T4042 5786-5792 NN denotes ADAM11
T4043 5793-5802 JJ denotes deficient
T4044 5792-5793 HYPH denotes -
T4045 5808-5812 NNS denotes mice
T4046 5803-5807 JJ denotes male
T4047 5813-5814 -LRB- denotes (
T4048 5826-5837 NNS denotes generations
T4049 5814-5825 VBN denotes backcrossed
T4050 5838-5842 IN denotes into
T4051 5843-5848 NN denotes C57BL
T4052 5849-5854 NN denotes 6NCrj
T4053 5848-5849 HYPH denotes /
T4054 5854-5856 , denotes ,
T4055 5856-5857 NN denotes n
T4056 5860-5862 CD denotes 14
T4057 5858-5859 SYM denotes =
T4058 5862-5863 -RRB- denotes )
T4059 5864-5868 VBD denotes were
T4060 5874-5876 IN denotes in
T4061 5877-5880 DT denotes all
T4062 5893-5901 NNS denotes analyses
T4063 5881-5892 JJ denotes behavioural
T4064 5902-5905 CC denotes and
T4065 5906-5916 JJ denotes anatomical
T4066 5917-5929 JJ denotes histological
T4067 5916-5917 HYPH denotes -
T4068 5930-5937 NNS denotes studies
T4069 5937-5938 . denotes .
T4070 5938-6082 sentence denotes Homozygous ADAM11-deficient mice were viable and appeared normal, indicating that the Adam11 gene is not essential to development and survival.
T4071 5939-5949 JJ denotes Homozygous
T4072 5967-5971 NNS denotes mice
T4073 5950-5956 NN denotes ADAM11
T4074 5957-5966 JJ denotes deficient
T4075 5956-5957 HYPH denotes -
T4076 5972-5976 VBD denotes were
T4077 5977-5983 JJ denotes viable
T4078 5984-5987 CC denotes and
T4079 5988-5996 VBD denotes appeared
T4080 5997-6003 JJ denotes normal
T4081 6003-6005 , denotes ,
T4082 6005-6015 VBG denotes indicating
T4083 6016-6020 IN denotes that
T4084 6037-6039 VBZ denotes is
T4085 6021-6024 DT denotes the
T4086 6032-6036 NN denotes gene
T4087 6025-6031 NN denotes Adam11
T4088 6040-6043 RB denotes not
T4089 6044-6053 JJ denotes essential
T4090 6054-6056 IN denotes to
T4091 6057-6068 NN denotes development
T4092 6069-6072 CC denotes and
T4093 6073-6081 NN denotes survival
T4094 6081-6082 . denotes .
T4095 6082-6216 sentence denotes The gain in body weight of (-/-) mice was comparable to that of (+/+) and (+/-) mice at least until 24 weeks of age (data not shown).
T4096 6083-6086 DT denotes The
T4097 6087-6091 NN denotes gain
T4098 6121-6124 VBD denotes was
T4099 6092-6094 IN denotes in
T4100 6095-6099 NN denotes body
T4101 6100-6106 NN denotes weight
T4102 6107-6109 IN denotes of
T4103 6110-6111 -LRB- denotes (
T4104 6116-6120 NNS denotes mice
T4105 6111-6112 SYM denotes -
T4106 6113-6114 SYM denotes -
T4107 6112-6113 HYPH denotes /
T4108 6114-6115 -RRB- denotes )
T4109 6125-6135 JJ denotes comparable
T4110 6136-6138 IN denotes to
T4111 6139-6143 DT denotes that
T4112 6144-6146 IN denotes of
T4113 6147-6148 -LRB- denotes (
T4114 6163-6167 NNS denotes mice
T4115 6148-6149 SYM denotes +
T4116 6150-6151 SYM denotes +
T4117 6149-6150 HYPH denotes /
T4118 6151-6152 -RRB- denotes )
T4119 6153-6156 CC denotes and
T4120 6157-6158 -LRB- denotes (
T4121 6160-6161 SYM denotes -
T4122 6158-6159 SYM denotes +
T4123 6159-6160 HYPH denotes /
T4124 6161-6162 -RRB- denotes )
T4125 6168-6170 RB denotes at
T4126 6171-6176 RBS denotes least
T4127 6177-6182 IN denotes until
T4128 6183-6185 CD denotes 24
T4129 6186-6191 NNS denotes weeks
T4130 6192-6194 IN denotes of
T4131 6195-6198 NN denotes age
T4132 6199-6200 -LRB- denotes (
T4133 6209-6214 VBN denotes shown
T4134 6200-6204 NNS denotes data
T4135 6205-6208 RB denotes not
T4136 6214-6215 -RRB- denotes )
T4137 6215-6216 . denotes .
T4138 6216-6331 sentence denotes There was no significant difference in locomotor activity among (+/+), (+/-) and (-/-) genotypes (data not shown).
T4139 6217-6222 EX denotes There
T4140 6223-6226 VBD denotes was
T4141 6227-6229 DT denotes no
T4142 6242-6252 NN denotes difference
T4143 6230-6241 JJ denotes significant
T4144 6253-6255 IN denotes in
T4145 6256-6265 NN denotes locomotor
T4146 6266-6274 NN denotes activity
T4147 6275-6280 IN denotes among
T4148 6281-6282 -LRB- denotes (
T4149 6304-6313 NNS denotes genotypes
T4150 6282-6283 SYM denotes +
T4151 6284-6285 SYM denotes +
T4152 6283-6284 HYPH denotes /
T4153 6285-6286 -RRB- denotes )
T4154 6286-6288 , denotes ,
T4155 6288-6289 -LRB- denotes (
T4156 6291-6292 SYM denotes -
T4157 6289-6290 SYM denotes +
T4158 6290-6291 HYPH denotes /
T4159 6292-6293 -RRB- denotes )
T4160 6294-6297 CC denotes and
T4161 6298-6299 -LRB- denotes (
T4162 6301-6302 SYM denotes -
T4163 6299-6300 SYM denotes -
T4164 6300-6301 HYPH denotes /
T4165 6302-6303 -RRB- denotes )
T4166 6314-6315 -LRB- denotes (
T4167 6324-6329 VBN denotes shown
T4168 6315-6319 NNS denotes data
T4169 6320-6323 RB denotes not
T4170 6329-6330 -RRB- denotes )
T4171 6330-6331 . denotes .
T4172 6331-6477 sentence denotes No apparent anatomical-histological change was observed in the spinal cord, heart, lung, liver, kidney, spleen, testis or ovary (data not shown).
T4173 6332-6334 DT denotes No
T4174 6368-6374 NN denotes change
T4175 6335-6343 JJ denotes apparent
T4176 6344-6354 JJ denotes anatomical
T4177 6355-6367 JJ denotes histological
T4178 6354-6355 HYPH denotes -
T4179 6379-6387 VBN denotes observed
T4180 6375-6378 VBD denotes was
T4181 6388-6390 IN denotes in
T4182 6391-6394 DT denotes the
T4183 6402-6406 NN denotes cord
T4184 6395-6401 JJ denotes spinal
T4185 6406-6408 , denotes ,
T4186 6408-6413 NN denotes heart
T4187 6413-6415 , denotes ,
T4188 6415-6419 NN denotes lung
T4189 6419-6421 , denotes ,
T4190 6421-6426 NN denotes liver
T4191 6426-6428 , denotes ,
T4192 6428-6434 NN denotes kidney
T4193 6434-6436 , denotes ,
T4194 6436-6442 NN denotes spleen
T4195 6442-6444 , denotes ,
T4196 6444-6450 NN denotes testis
T4197 6451-6453 CC denotes or
T4198 6454-6459 NN denotes ovary
T4199 6460-6461 -LRB- denotes (
T4200 6470-6475 VBN denotes shown
T4201 6461-6465 NNS denotes data
T4202 6466-6469 RB denotes not
T4203 6475-6476 -RRB- denotes )
T4204 6476-6477 . denotes .
T4205 6477-6645 sentence denotes The brain of (-/-) mice, including the hippocampus (Fig. 1D) and cerebellum (Fig. 1E) appeared normal after HE staining when (+/+), (+/-) and (-/-) mice were compared.
T4206 6478-6481 DT denotes The
T4207 6482-6487 NN denotes brain
T4208 6564-6572 VBD denotes appeared
T4209 6488-6490 IN denotes of
T4210 6491-6492 -LRB- denotes (
T4211 6497-6501 NNS denotes mice
T4212 6492-6493 SYM denotes -
T4213 6494-6495 SYM denotes -
T4214 6493-6494 HYPH denotes /
T4215 6495-6496 -RRB- denotes )
T4216 6501-6503 , denotes ,
T4217 6503-6512 VBG denotes including
T4218 6513-6516 DT denotes the
T4219 6517-6528 NN denotes hippocampus
T4220 6529-6530 -LRB- denotes (
T4221 6535-6537 NN denotes 1D
T4222 6530-6534 NN denotes Fig.
T4223 6537-6538 -RRB- denotes )
T4224 6539-6542 CC denotes and
T4225 6543-6553 NN denotes cerebellum
T4226 6554-6555 -LRB- denotes (
T4227 6560-6562 NN denotes 1E
T4228 6555-6559 NN denotes Fig.
T4229 6562-6563 -RRB- denotes )
T4230 6573-6579 JJ denotes normal
T4231 6580-6585 IN denotes after
T4232 6586-6588 NN denotes HE
T4233 6589-6597 NN denotes staining
T4234 6598-6602 WRB denotes when
T4235 6636-6644 VBN denotes compared
T4236 6603-6604 -LRB- denotes (
T4237 6626-6630 NNS denotes mice
T4238 6604-6605 SYM denotes +
T4239 6606-6607 SYM denotes +
T4240 6605-6606 HYPH denotes /
T4241 6607-6608 -RRB- denotes )
T4242 6608-6610 , denotes ,
T4243 6610-6611 -LRB- denotes (
T4244 6613-6614 SYM denotes -
T4245 6611-6612 SYM denotes +
T4246 6612-6613 HYPH denotes /
T4247 6614-6615 -RRB- denotes )
T4248 6616-6619 CC denotes and
T4249 6620-6621 -LRB- denotes (
T4250 6623-6624 SYM denotes -
T4251 6621-6622 SYM denotes -
T4252 6622-6623 HYPH denotes /
T4253 6624-6625 -RRB- denotes )
T4254 6631-6635 VBD denotes were
T4255 6644-6645 . denotes .
T4256 6645-6790 sentence denotes Since Adam11 is predominantly expressed in the hippocampus and cerebellum, we applied hippocampus- or cerebellum-dependent behavioural analyses.
T4257 6646-6651 IN denotes Since
T4258 6676-6685 VBN denotes expressed
T4259 6652-6658 NN denotes Adam11
T4260 6659-6661 VBZ denotes is
T4261 6662-6675 RB denotes predominantly
T4262 6724-6731 VBD denotes applied
T4263 6686-6688 IN denotes in
T4264 6689-6692 DT denotes the
T4265 6693-6704 NN denotes hippocampus
T4266 6705-6708 CC denotes and
T4267 6709-6719 NN denotes cerebellum
T4268 6719-6721 , denotes ,
T4269 6721-6723 PRP denotes we
T4270 6732-6743 NN denotes hippocampus
T4271 6759-6768 JJ denotes dependent
T4272 6743-6744 HYPH denotes -
T4273 6745-6747 CC denotes or
T4274 6748-6758 NN denotes cerebellum
T4275 6758-6759 HYPH denotes -
T4276 6781-6789 NNS denotes analyses
T4277 6769-6780 JJ denotes behavioural
T4278 6789-6790 . denotes .
T5243 6800-6808 NN denotes learning
T5242 6792-6799 JJ denotes Spatial
T5244 6809-6811 IN denotes in
T5245 6812-6818 NN denotes ADAM11
T5246 6819-6828 JJ denotes deficient
T5247 6818-6819 HYPH denotes -
T5248 6829-6833 NNS denotes mice
T5249 6833-6991 sentence denotes To study the functions of ADAM11 in the hippocampus, we examined the spatial learning ability of ADAM11-deficient mice using the Morris Water Maze task [27].
T5250 6834-6836 TO denotes To
T5251 6837-6842 VB denotes study
T5252 6890-6898 VBD denotes examined
T5253 6843-6846 DT denotes the
T5254 6847-6856 NNS denotes functions
T5255 6857-6859 IN denotes of
T5256 6860-6866 NN denotes ADAM11
T5257 6867-6869 IN denotes in
T5258 6870-6873 DT denotes the
T5259 6874-6885 NN denotes hippocampus
T5260 6885-6887 , denotes ,
T5261 6887-6889 PRP denotes we
T5262 6899-6902 DT denotes the
T5263 6920-6927 NN denotes ability
T5264 6903-6910 JJ denotes spatial
T5265 6911-6919 NN denotes learning
T5266 6928-6930 IN denotes of
T5267 6931-6937 NN denotes ADAM11
T5268 6938-6947 JJ denotes deficient
T5269 6937-6938 HYPH denotes -
T5270 6948-6952 NNS denotes mice
T5271 6953-6958 VBG denotes using
T5272 6959-6962 DT denotes the
T5273 6981-6985 NN denotes task
T5274 6963-6969 NNP denotes Morris
T5275 6976-6980 NNP denotes Maze
T5276 6970-6975 NNP denotes Water
T5277 6986-6987 -LRB- denotes [
T5278 6987-6989 CD denotes 27
T5279 6989-6990 -RRB- denotes ]
T5280 6990-6991 . denotes .
T5281 6991-7117 sentence denotes First, mice were trained in a hidden platform task, in which mice searched for a submerged platform to escape from the water.
T5282 6992-6997 RB denotes First
T5283 7009-7016 VBN denotes trained
T5284 6997-6999 , denotes ,
T5285 6999-7003 NNS denotes mice
T5286 7004-7008 VBD denotes were
T5287 7017-7019 IN denotes in
T5288 7020-7021 DT denotes a
T5289 7038-7042 NN denotes task
T5290 7022-7028 JJ denotes hidden
T5291 7029-7037 NN denotes platform
T5292 7042-7044 , denotes ,
T5293 7044-7046 IN denotes in
T5294 7058-7066 VBD denotes searched
T5295 7047-7052 WDT denotes which
T5296 7053-7057 NNS denotes mice
T5297 7067-7070 IN denotes for
T5298 7071-7072 DT denotes a
T5299 7083-7091 NN denotes platform
T5300 7073-7082 VBN denotes submerged
T5301 7092-7094 TO denotes to
T5302 7095-7101 VB denotes escape
T5303 7102-7106 IN denotes from
T5304 7107-7110 DT denotes the
T5305 7111-7116 NN denotes water
T5306 7116-7117 . denotes .
T5307 7117-7249 sentence denotes Adam11 (-/-) mice were found to take a significantly longer time to locate the hidden platform than (+/+) and (+/-) mice (Fig. 2A).
T5308 7118-7124 NN denotes Adam11
T5309 7131-7135 NNS denotes mice
T5310 7125-7126 -LRB- denotes (
T5311 7126-7127 SYM denotes -
T5312 7127-7128 HYPH denotes /
T5313 7128-7129 SYM denotes -
T5314 7129-7130 -RRB- denotes )
T5315 7141-7146 VBN denotes found
T5316 7136-7140 VBD denotes were
T5317 7147-7149 TO denotes to
T5318 7150-7154 VB denotes take
T5319 7155-7156 DT denotes a
T5320 7178-7182 NN denotes time
T5321 7157-7170 RB denotes significantly
T5322 7171-7177 JJR denotes longer
T5323 7183-7185 TO denotes to
T5324 7186-7192 VB denotes locate
T5325 7193-7196 DT denotes the
T5326 7204-7212 NN denotes platform
T5327 7197-7203 JJ denotes hidden
T5328 7213-7217 IN denotes than
T5329 7218-7219 -LRB- denotes (
T5330 7234-7238 NNS denotes mice
T5331 7219-7220 SYM denotes +
T5332 7221-7222 SYM denotes +
T5333 7220-7221 HYPH denotes /
T5334 7222-7223 -RRB- denotes )
T5335 7224-7227 CC denotes and
T5336 7228-7229 -LRB- denotes (
T5337 7231-7232 SYM denotes -
T5338 7229-7230 SYM denotes +
T5339 7230-7231 HYPH denotes /
T5340 7232-7233 -RRB- denotes )
T5341 7239-7240 -LRB- denotes (
T5342 7245-7247 NN denotes 2A
T5343 7240-7244 NN denotes Fig.
T5344 7247-7248 -RRB- denotes )
T5345 7248-7249 . denotes .
T5346 7249-7372 sentence denotes Nonetheless, the ability of (+/+), (+/-) and (-/-) mice to find the hidden platform improved over test sessions (Fig. 2A).
T5347 7250-7261 RB denotes Nonetheless
T5348 7334-7342 VBN denotes improved
T5349 7261-7263 , denotes ,
T5350 7263-7266 DT denotes the
T5351 7267-7274 NN denotes ability
T5352 7275-7277 IN denotes of
T5353 7278-7279 -LRB- denotes (
T5354 7301-7305 NNS denotes mice
T5355 7279-7280 SYM denotes +
T5356 7281-7282 SYM denotes +
T5357 7280-7281 HYPH denotes /
T5358 7282-7283 -RRB- denotes )
T5359 7283-7285 , denotes ,
T5360 7285-7286 -LRB- denotes (
T5361 7288-7289 SYM denotes -
T5362 7286-7287 SYM denotes +
T5363 7287-7288 HYPH denotes /
T5364 7289-7290 -RRB- denotes )
T5365 7291-7294 CC denotes and
T5366 7295-7296 -LRB- denotes (
T5367 7298-7299 SYM denotes -
T5368 7296-7297 SYM denotes -
T5369 7297-7298 HYPH denotes /
T5370 7299-7300 -RRB- denotes )
T5371 7306-7308 TO denotes to
T5372 7309-7313 VB denotes find
T5373 7314-7317 DT denotes the
T5374 7325-7333 NN denotes platform
T5375 7318-7324 JJ denotes hidden
T5376 7343-7347 IN denotes over
T5377 7348-7352 NN denotes test
T5378 7353-7361 NNS denotes sessions
T5379 7362-7363 -LRB- denotes (
T5380 7368-7370 NN denotes 2A
T5381 7363-7367 NN denotes Fig.
T5382 7370-7371 -RRB- denotes )
T5383 7371-7372 . denotes .
T5384 7372-7596 sentence denotes Thus, (+/+), (+/-) and (-/-) mice were able to learn the location of the hidden platform during the course of the trials, although the capacity of (-/-) mice to find the platform was lower than that of (+/+) and (+/-) mice.
T5385 7373-7377 RB denotes Thus
T5386 7407-7411 VBD denotes were
T5387 7377-7379 , denotes ,
T5388 7379-7380 -LRB- denotes (
T5389 7402-7406 NNS denotes mice
T5390 7380-7381 SYM denotes +
T5391 7382-7383 SYM denotes +
T5392 7381-7382 HYPH denotes /
T5393 7383-7384 -RRB- denotes )
T5394 7384-7386 , denotes ,
T5395 7386-7387 -LRB- denotes (
T5396 7389-7390 SYM denotes -
T5397 7387-7388 SYM denotes +
T5398 7388-7389 HYPH denotes /
T5399 7390-7391 -RRB- denotes )
T5400 7392-7395 CC denotes and
T5401 7396-7397 -LRB- denotes (
T5402 7399-7400 SYM denotes -
T5403 7397-7398 SYM denotes -
T5404 7398-7399 HYPH denotes /
T5405 7400-7401 -RRB- denotes )
T5406 7412-7416 JJ denotes able
T5407 7417-7419 TO denotes to
T5408 7420-7425 VB denotes learn
T5409 7426-7429 DT denotes the
T5410 7430-7438 NN denotes location
T5411 7439-7441 IN denotes of
T5412 7442-7445 DT denotes the
T5413 7453-7461 NN denotes platform
T5414 7446-7452 JJ denotes hidden
T5415 7462-7468 IN denotes during
T5416 7469-7472 DT denotes the
T5417 7473-7479 NN denotes course
T5418 7480-7482 IN denotes of
T5419 7483-7486 DT denotes the
T5420 7487-7493 NNS denotes trials
T5421 7493-7495 , denotes ,
T5422 7495-7503 IN denotes although
T5423 7552-7555 VBD denotes was
T5424 7504-7507 DT denotes the
T5425 7508-7516 NN denotes capacity
T5426 7517-7519 IN denotes of
T5427 7520-7521 -LRB- denotes (
T5428 7521-7522 SYM denotes -
T5429 7523-7524 SYM denotes -
T5430 7522-7523 HYPH denotes /
T5431 7526-7530 NNS denotes mice
T5432 7524-7525 -RRB- denotes )
T5433 7531-7533 TO denotes to
T5434 7534-7538 VB denotes find
T5435 7539-7542 DT denotes the
T5436 7543-7551 NN denotes platform
T5437 7556-7561 JJR denotes lower
T5438 7562-7566 IN denotes than
T5439 7567-7571 DT denotes that
T5440 7572-7574 IN denotes of
T5441 7575-7576 -LRB- denotes (
T5442 7591-7595 NNS denotes mice
T5443 7576-7577 SYM denotes +
T5444 7578-7579 SYM denotes +
T5445 7577-7578 HYPH denotes /
T5446 7579-7580 -RRB- denotes )
T5447 7581-7584 CC denotes and
T5448 7585-7586 -LRB- denotes (
T5449 7588-7589 SYM denotes -
T5450 7586-7587 SYM denotes +
T5451 7587-7588 HYPH denotes /
T5452 7589-7590 -RRB- denotes )
T5453 7595-7596 . denotes .
T5454 7596-7786 sentence denotes We further performed a probe test, in which the platform was removed from the pool after completion of the hidden platform task, and the trained mice were allowed to swim freely for 60 sec.
T5455 7597-7599 PRP denotes We
T5456 7608-7617 VBD denotes performed
T5457 7600-7607 RB denotes further
T5458 7618-7619 DT denotes a
T5459 7626-7630 NN denotes test
T5460 7620-7625 NN denotes probe
T5461 7630-7632 , denotes ,
T5462 7632-7634 IN denotes in
T5463 7658-7665 VBN denotes removed
T5464 7635-7640 WDT denotes which
T5465 7641-7644 DT denotes the
T5466 7645-7653 NN denotes platform
T5467 7654-7657 VBD denotes was
T5468 7666-7670 IN denotes from
T5469 7671-7674 DT denotes the
T5470 7675-7679 NN denotes pool
T5471 7680-7685 IN denotes after
T5472 7686-7696 NN denotes completion
T5473 7697-7699 IN denotes of
T5474 7700-7703 DT denotes the
T5475 7720-7724 NN denotes task
T5476 7704-7710 JJ denotes hidden
T5477 7711-7719 NN denotes platform
T5478 7724-7726 , denotes ,
T5479 7726-7729 CC denotes and
T5480 7730-7733 DT denotes the
T5481 7742-7746 NNS denotes mice
T5482 7734-7741 VBN denotes trained
T5483 7752-7759 VBN denotes allowed
T5484 7747-7751 VBD denotes were
T5485 7760-7762 TO denotes to
T5486 7763-7767 VB denotes swim
T5487 7768-7774 RB denotes freely
T5488 7775-7778 IN denotes for
T5489 7779-7781 CD denotes 60
T5490 7782-7785 NN denotes sec
T5491 7785-7786 . denotes .
T5492 7786-7891 sentence denotes The time spent in the target quadrant of (-/-) is significantly lower than that of (+/+) mice (Fig. 2B).
T5493 7787-7790 DT denotes The
T5494 7791-7795 NN denotes time
T5495 7834-7836 VBZ denotes is
T5496 7796-7801 VBN denotes spent
T5497 7802-7804 IN denotes in
T5498 7805-7808 DT denotes the
T5499 7816-7824 NN denotes quadrant
T5500 7809-7815 NN denotes target
T5501 7825-7827 IN denotes of
T5502 7828-7829 -LRB- denotes (
T5503 7829-7830 SYM denotes -
T5504 7831-7832 SYM denotes -
T5505 7830-7831 HYPH denotes /
T5506 7832-7833 -RRB- denotes )
T5507 7837-7850 RB denotes significantly
T5508 7851-7856 JJR denotes lower
T5509 7857-7861 IN denotes than
T5510 7862-7866 DT denotes that
T5511 7867-7869 IN denotes of
T5512 7870-7871 -LRB- denotes (
T5513 7876-7880 NNS denotes mice
T5514 7871-7872 SYM denotes +
T5515 7873-7874 SYM denotes +
T5516 7872-7873 HYPH denotes /
T5517 7874-7875 -RRB- denotes )
T5518 7881-7882 -LRB- denotes (
T5519 7887-7889 NN denotes 2B
T5520 7882-7886 NN denotes Fig.
T5521 7889-7890 -RRB- denotes )
T5522 7890-7891 . denotes .
T5523 7891-8046 sentence denotes Adam11 (+/-) mice appeared to spend a shorter time in the target quadrant, but there was no significant difference between (+/+) and (+/-) mice (Fig. 2B).
T5524 7892-7898 NN denotes Adam11
T5525 7905-7909 NNS denotes mice
T5526 7899-7900 -LRB- denotes (
T5527 7900-7901 SYM denotes +
T5528 7901-7902 HYPH denotes /
T5529 7902-7903 SYM denotes -
T5530 7903-7904 -RRB- denotes )
T5531 7910-7918 VBD denotes appeared
T5532 7919-7921 TO denotes to
T5533 7922-7927 VB denotes spend
T5534 7928-7929 DT denotes a
T5535 7938-7942 NN denotes time
T5536 7930-7937 JJR denotes shorter
T5537 7943-7945 IN denotes in
T5538 7946-7949 DT denotes the
T5539 7957-7965 NN denotes quadrant
T5540 7950-7956 NN denotes target
T5541 7965-7967 , denotes ,
T5542 7967-7970 CC denotes but
T5543 7971-7976 EX denotes there
T5544 7977-7980 VBD denotes was
T5545 7981-7983 DT denotes no
T5546 7996-8006 NN denotes difference
T5547 7984-7995 JJ denotes significant
T5548 8007-8014 IN denotes between
T5549 8015-8016 -LRB- denotes (
T5550 8016-8017 SYM denotes +
T5551 8018-8019 SYM denotes +
T5552 8017-8018 HYPH denotes /
T5553 8031-8035 NNS denotes mice
T5554 8019-8020 -RRB- denotes )
T5555 8021-8024 CC denotes and
T5556 8025-8026 -LRB- denotes (
T5557 8028-8029 SYM denotes -
T5558 8026-8027 SYM denotes +
T5559 8027-8028 HYPH denotes /
T5560 8029-8030 -RRB- denotes )
T5561 8036-8037 -LRB- denotes (
T5562 8042-8044 NN denotes 2B
T5563 8037-8041 NN denotes Fig.
T5564 8044-8045 -RRB- denotes )
T5565 8045-8046 . denotes .
T5566 8046-8114 sentence denotes These results indicate a spatial learning impairment in (-/-) mice.
T5567 8047-8052 DT denotes These
T5568 8053-8060 NNS denotes results
T5569 8061-8069 VBP denotes indicate
T5570 8070-8071 DT denotes a
T5571 8089-8099 NN denotes impairment
T5572 8072-8079 JJ denotes spatial
T5573 8080-8088 NN denotes learning
T5574 8100-8102 IN denotes in
T5575 8103-8104 -LRB- denotes (
T5576 8109-8113 NNS denotes mice
T5577 8104-8105 SYM denotes -
T5578 8106-8107 SYM denotes -
T5579 8105-8106 HYPH denotes /
T5580 8107-8108 -RRB- denotes )
T5581 8113-8114 . denotes .
T5582 8114-8223 sentence denotes The swimming distance of (+/+), (+/-) and (-/-) mice, however, was similar during the probe trial (Fig. 2C).
T5583 8115-8118 DT denotes The
T5584 8128-8136 NN denotes distance
T5585 8119-8127 NN denotes swimming
T5586 8178-8181 VBD denotes was
T5587 8137-8139 IN denotes of
T5588 8140-8141 -LRB- denotes (
T5589 8163-8167 NNS denotes mice
T5590 8141-8142 SYM denotes +
T5591 8143-8144 SYM denotes +
T5592 8142-8143 HYPH denotes /
T5593 8144-8145 -RRB- denotes )
T5594 8145-8147 , denotes ,
T5595 8147-8148 -LRB- denotes (
T5596 8150-8151 SYM denotes -
T5597 8148-8149 SYM denotes +
T5598 8149-8150 HYPH denotes /
T5599 8151-8152 -RRB- denotes )
T5600 8153-8156 CC denotes and
T5601 8157-8158 -LRB- denotes (
T5602 8160-8161 SYM denotes -
T5603 8158-8159 SYM denotes -
T5604 8159-8160 HYPH denotes /
T5605 8161-8162 -RRB- denotes )
T5606 8167-8169 , denotes ,
T5607 8169-8176 RB denotes however
T5608 8176-8178 , denotes ,
T5609 8182-8189 JJ denotes similar
T5610 8190-8196 IN denotes during
T5611 8197-8200 DT denotes the
T5612 8207-8212 NN denotes trial
T5613 8201-8206 NN denotes probe
T5614 8213-8214 -LRB- denotes (
T5615 8219-8221 NN denotes 2C
T5616 8214-8218 NN denotes Fig.
T5617 8221-8222 -RRB- denotes )
T5618 8222-8223 . denotes .
T5619 8223-8553 sentence denotes In the visible platform task, the performance of mice with (+/+), (+/-) and (-/-) genotypes improved during the course of the test sessions, as indicated by a progressive decrease in the latency for locating the platform (Fig. 2D), suggesting that (-/-) mice learn this visible platform task just as well as (+/+) and (+/-) mice.
T5620 8224-8226 IN denotes In
T5621 8316-8324 VBD denotes improved
T5622 8227-8230 DT denotes the
T5623 8248-8252 NN denotes task
T5624 8231-8238 JJ denotes visible
T5625 8239-8247 NN denotes platform
T5626 8252-8254 , denotes ,
T5627 8254-8257 DT denotes the
T5628 8258-8269 NN denotes performance
T5629 8270-8272 IN denotes of
T5630 8273-8277 NNS denotes mice
T5631 8278-8282 IN denotes with
T5632 8283-8284 -LRB- denotes (
T5633 8306-8315 NNS denotes genotypes
T5634 8284-8285 SYM denotes +
T5635 8286-8287 SYM denotes +
T5636 8285-8286 HYPH denotes /
T5637 8287-8288 -RRB- denotes )
T5638 8288-8290 , denotes ,
T5639 8290-8291 -LRB- denotes (
T5640 8293-8294 SYM denotes -
T5641 8291-8292 SYM denotes +
T5642 8292-8293 HYPH denotes /
T5643 8294-8295 -RRB- denotes )
T5644 8296-8299 CC denotes and
T5645 8300-8301 -LRB- denotes (
T5646 8303-8304 SYM denotes -
T5647 8301-8302 SYM denotes -
T5648 8302-8303 HYPH denotes /
T5649 8304-8305 -RRB- denotes )
T5650 8325-8331 IN denotes during
T5651 8332-8335 DT denotes the
T5652 8336-8342 NN denotes course
T5653 8343-8345 IN denotes of
T5654 8346-8349 DT denotes the
T5655 8355-8363 NNS denotes sessions
T5656 8350-8354 NN denotes test
T5657 8363-8365 , denotes ,
T5658 8365-8367 IN denotes as
T5659 8368-8377 VBN denotes indicated
T5660 8378-8380 IN denotes by
T5661 8381-8382 DT denotes a
T5662 8395-8403 NN denotes decrease
T5663 8383-8394 JJ denotes progressive
T5664 8404-8406 IN denotes in
T5665 8407-8410 DT denotes the
T5666 8411-8418 NN denotes latency
T5667 8419-8422 IN denotes for
T5668 8423-8431 VBG denotes locating
T5669 8432-8435 DT denotes the
T5670 8436-8444 NN denotes platform
T5671 8445-8446 -LRB- denotes (
T5672 8451-8453 NN denotes 2D
T5673 8446-8450 NN denotes Fig.
T5674 8453-8454 -RRB- denotes )
T5675 8454-8456 , denotes ,
T5676 8456-8466 VBG denotes suggesting
T5677 8467-8471 IN denotes that
T5678 8483-8488 VBP denotes learn
T5679 8472-8473 -LRB- denotes (
T5680 8478-8482 NNS denotes mice
T5681 8473-8474 SYM denotes -
T5682 8475-8476 SYM denotes -
T5683 8474-8475 HYPH denotes /
T5684 8476-8477 -RRB- denotes )
T5685 8489-8493 DT denotes this
T5686 8511-8515 NN denotes task
T5687 8494-8501 JJ denotes visible
T5688 8502-8510 NN denotes platform
T5689 8516-8520 RB denotes just
T5690 8524-8528 RB denotes well
T5691 8521-8523 RB denotes as
T5692 8529-8531 IN denotes as
T5693 8532-8533 -LRB- denotes (
T5694 8548-8552 NNS denotes mice
T5695 8533-8534 SYM denotes +
T5696 8535-8536 SYM denotes +
T5697 8534-8535 HYPH denotes /
T5698 8536-8537 -RRB- denotes )
T5699 8538-8541 CC denotes and
T5700 8542-8543 -LRB- denotes (
T5701 8545-8546 SYM denotes -
T5702 8543-8544 SYM denotes +
T5703 8544-8545 HYPH denotes /
T5704 8546-8547 -RRB- denotes )
T5705 8552-8553 . denotes .
T5706 8553-8687 sentence denotes These results also indicated that (-/-) mice have normal visible and motor function and the motivation needed in the water maze task.
T5707 8554-8559 DT denotes These
T5708 8560-8567 NNS denotes results
T5709 8573-8582 VBD denotes indicated
T5710 8568-8572 RB denotes also
T5711 8583-8587 IN denotes that
T5712 8599-8603 VBP denotes have
T5713 8588-8589 -LRB- denotes (
T5714 8594-8598 NNS denotes mice
T5715 8589-8590 SYM denotes -
T5716 8591-8592 SYM denotes -
T5717 8590-8591 HYPH denotes /
T5718 8592-8593 -RRB- denotes )
T5719 8604-8610 JJ denotes normal
T5720 8629-8637 NN denotes function
T5721 8611-8618 JJ denotes visible
T5722 8619-8622 CC denotes and
T5723 8623-8628 JJ denotes motor
T5724 8638-8641 CC denotes and
T5725 8642-8645 DT denotes the
T5726 8646-8656 NN denotes motivation
T5727 8657-8663 VBN denotes needed
T5728 8664-8666 IN denotes in
T5729 8667-8670 DT denotes the
T5730 8682-8686 NN denotes task
T5731 8671-8676 NN denotes water
T5732 8677-8681 NN denotes maze
T5733 8686-8687 . denotes .
T6623 8689-8694 NN denotes Motor
T6624 8695-8703 NN denotes function
T6625 8704-8706 IN denotes of
T6626 8707-8713 NN denotes ADAM11
T6627 8714-8723 JJ denotes deficient
T6628 8713-8714 HYPH denotes -
T6629 8724-8728 NNS denotes mice
T6630 8728-8868 sentence denotes To study the functions of ADAM11 in the cerebellum, we examined the motor function of ADAM11-deficient mice using a rotating rod task [28].
T6631 8729-8731 TO denotes To
T6632 8732-8737 VB denotes study
T6633 8784-8792 VBD denotes examined
T6634 8738-8741 DT denotes the
T6635 8742-8751 NNS denotes functions
T6636 8752-8754 IN denotes of
T6637 8755-8761 NN denotes ADAM11
T6638 8762-8764 IN denotes in
T6639 8765-8768 DT denotes the
T6640 8769-8779 NN denotes cerebellum
T6641 8779-8781 , denotes ,
T6642 8781-8783 PRP denotes we
T6643 8793-8796 DT denotes the
T6644 8803-8811 NN denotes function
T6645 8797-8802 JJ denotes motor
T6646 8812-8814 IN denotes of
T6647 8815-8821 NN denotes ADAM11
T6648 8822-8831 JJ denotes deficient
T6649 8821-8822 HYPH denotes -
T6650 8832-8836 NNS denotes mice
T6651 8837-8842 VBG denotes using
T6652 8843-8844 DT denotes a
T6653 8858-8862 NN denotes task
T6654 8845-8853 VBG denotes rotating
T6655 8854-8857 NN denotes rod
T6656 8863-8864 -LRB- denotes [
T6657 8864-8866 CD denotes 28
T6658 8866-8867 -RRB- denotes ]
T6659 8867-8868 . denotes .
T6660 8868-9105 sentence denotes In the rotating rod test, the retention time of (+/-) and (-/-) mice on the rod was not significantly different from that of (+/+) mice at 0 rpm (stationary) [+/-: F (1, 80) = 1.67, p = 0.21; -/-: F (1, 88) = 0.002, p = 0.96] (Fig. 3A).
T6661 8869-8871 IN denotes In
T6662 8949-8952 VBD denotes was
T6663 8872-8875 DT denotes the
T6664 8889-8893 NN denotes test
T6665 8876-8884 VBG denotes rotating
T6666 8885-8888 NN denotes rod
T6667 8893-8895 , denotes ,
T6668 8895-8898 DT denotes the
T6669 8909-8913 NN denotes time
T6670 8899-8908 NN denotes retention
T6671 8914-8916 IN denotes of
T6672 8917-8918 -LRB- denotes (
T6673 8933-8937 NNS denotes mice
T6674 8918-8919 SYM denotes +
T6675 8920-8921 SYM denotes -
T6676 8919-8920 HYPH denotes /
T6677 8921-8922 -RRB- denotes )
T6678 8923-8926 CC denotes and
T6679 8927-8928 -LRB- denotes (
T6680 8930-8931 SYM denotes -
T6681 8928-8929 SYM denotes -
T6682 8929-8930 HYPH denotes /
T6683 8931-8932 -RRB- denotes )
T6684 8938-8940 IN denotes on
T6685 8941-8944 DT denotes the
T6686 8945-8948 NN denotes rod
T6687 8953-8956 RB denotes not
T6688 8957-8970 RB denotes significantly
T6689 8971-8980 JJ denotes different
T6690 8981-8985 IN denotes from
T6691 8986-8990 DT denotes that
T6692 8991-8993 IN denotes of
T6693 8994-8995 -LRB- denotes (
T6694 9000-9004 NNS denotes mice
T6695 8995-8996 SYM denotes +
T6696 8997-8998 SYM denotes +
T6697 8996-8997 HYPH denotes /
T6698 8998-8999 -RRB- denotes )
T6699 9005-9007 IN denotes at
T6700 9008-9009 CD denotes 0
T6701 9010-9013 NN denotes rpm
T6702 9014-9015 -LRB- denotes (
T6703 9015-9025 JJ denotes stationary
T6704 9025-9026 -RRB- denotes )
T6705 9027-9028 -LRB- denotes [
T6706 9089-9093 CD denotes 0.96
T6707 9028-9029 SYM denotes +
T6708 9030-9031 SYM denotes -
T6709 9029-9030 HYPH denotes /
T6710 9055-9059 CD denotes 0.21
T6711 9031-9033 : denotes :
T6712 9033-9034 NN denotes F
T6713 9045-9049 CD denotes 1.67
T6714 9035-9036 -LRB- denotes (
T6715 9036-9037 CD denotes 1
T6716 9037-9039 , denotes ,
T6717 9039-9041 CD denotes 80
T6718 9041-9042 -RRB- denotes )
T6719 9043-9044 SYM denotes =
T6720 9049-9051 , denotes ,
T6721 9051-9052 NN denotes p
T6722 9053-9054 SYM denotes =
T6723 9059-9060 : denotes ;
T6724 9061-9062 SYM denotes -
T6725 9063-9064 SYM denotes -
T6726 9062-9063 HYPH denotes /
T6727 9064-9066 : denotes :
T6728 9066-9067 NN denotes F
T6729 9078-9083 CD denotes 0.002
T6730 9068-9069 -LRB- denotes (
T6731 9069-9070 CD denotes 1
T6732 9070-9072 , denotes ,
T6733 9072-9074 CD denotes 88
T6734 9074-9075 -RRB- denotes )
T6735 9076-9077 SYM denotes =
T6736 9083-9085 , denotes ,
T6737 9085-9086 NN denotes p
T6738 9087-9088 SYM denotes =
T6739 9093-9094 -RRB- denotes ]
T6740 9095-9096 -LRB- denotes (
T6741 9101-9103 NN denotes 3A
T6742 9096-9100 NN denotes Fig.
T6743 9103-9104 -RRB- denotes )
T6744 9104-9105 . denotes .
T6745 9105-9393 sentence denotes In (+/-) mice, the tendency of decreased retention times was seen at 5, 10 and 15 rpm, but there was no significant difference between (+/+) and (+/-) mice [5 rpm: F (1, 20) = 1.27, p = 0.27; 10 rpm: F (1, 20) = 1.07, p = 0.31; 15 rpm: F (1, 20) = 2.716, p = 0.11] (Figs. 3B, 3C and 3D).
T6746 9106-9108 IN denotes In
T6747 9167-9171 VBN denotes seen
T6748 9109-9110 -LRB- denotes (
T6749 9115-9119 NNS denotes mice
T6750 9110-9111 SYM denotes +
T6751 9112-9113 SYM denotes -
T6752 9111-9112 HYPH denotes /
T6753 9113-9114 -RRB- denotes )
T6754 9119-9121 , denotes ,
T6755 9121-9124 DT denotes the
T6756 9125-9133 NN denotes tendency
T6757 9134-9136 IN denotes of
T6758 9137-9146 VBN denotes decreased
T6759 9157-9162 NNS denotes times
T6760 9147-9156 NN denotes retention
T6761 9163-9166 VBD denotes was
T6762 9172-9174 IN denotes at
T6763 9175-9176 CD denotes 5
T6764 9188-9191 NN denotes rpm
T6765 9176-9178 , denotes ,
T6766 9178-9180 CD denotes 10
T6767 9181-9184 CC denotes and
T6768 9185-9187 CD denotes 15
T6769 9191-9193 , denotes ,
T6770 9193-9196 CC denotes but
T6771 9197-9202 EX denotes there
T6772 9203-9206 VBD denotes was
T6773 9207-9209 DT denotes no
T6774 9222-9232 NN denotes difference
T6775 9210-9221 JJ denotes significant
T6776 9233-9240 IN denotes between
T6777 9241-9242 -LRB- denotes (
T6778 9257-9261 NNS denotes mice
T6779 9242-9243 SYM denotes +
T6780 9244-9245 SYM denotes +
T6781 9243-9244 HYPH denotes /
T6782 9245-9246 -RRB- denotes )
T6783 9247-9250 CC denotes and
T6784 9251-9252 -LRB- denotes (
T6785 9254-9255 SYM denotes -
T6786 9252-9253 SYM denotes +
T6787 9253-9254 HYPH denotes /
T6788 9255-9256 -RRB- denotes )
T6789 9262-9263 -LRB- denotes [
T6790 9365-9369 CD denotes 0.11
T6791 9263-9264 CD denotes 5
T6792 9265-9268 NN denotes rpm
T6793 9292-9296 CD denotes 0.27
T6794 9268-9270 : denotes :
T6795 9270-9271 NN denotes F
T6796 9282-9286 CD denotes 1.27
T6797 9272-9273 -LRB- denotes (
T6798 9273-9274 CD denotes 1
T6799 9274-9276 , denotes ,
T6800 9276-9278 CD denotes 20
T6801 9278-9279 -RRB- denotes )
T6802 9280-9281 SYM denotes =
T6803 9286-9288 , denotes ,
T6804 9288-9289 NN denotes p
T6805 9290-9291 SYM denotes =
T6806 9296-9297 : denotes ;
T6807 9298-9300 CD denotes 10
T6808 9301-9304 NN denotes rpm
T6809 9328-9332 CD denotes 0.31
T6810 9304-9306 : denotes :
T6811 9306-9307 NN denotes F
T6812 9318-9322 CD denotes 1.07
T6813 9308-9309 -LRB- denotes (
T6814 9309-9310 CD denotes 1
T6815 9310-9312 , denotes ,
T6816 9312-9314 CD denotes 20
T6817 9314-9315 -RRB- denotes )
T6818 9316-9317 SYM denotes =
T6819 9322-9324 , denotes ,
T6820 9324-9325 NN denotes p
T6821 9326-9327 SYM denotes =
T6822 9332-9333 : denotes ;
T6823 9334-9336 CD denotes 15
T6824 9337-9340 NN denotes rpm
T6825 9340-9342 : denotes :
T6826 9342-9343 NN denotes F
T6827 9354-9359 CD denotes 2.716
T6828 9344-9345 -LRB- denotes (
T6829 9345-9346 CD denotes 1
T6830 9346-9348 , denotes ,
T6831 9348-9350 CD denotes 20
T6832 9350-9351 -RRB- denotes )
T6833 9352-9353 SYM denotes =
T6834 9359-9361 , denotes ,
T6835 9361-9362 NN denotes p
T6836 9363-9364 SYM denotes =
T6837 9369-9370 -RRB- denotes ]
T6838 9371-9372 -LRB- denotes (
T6839 9378-9380 NN denotes 3B
T6840 9372-9377 NNS denotes Figs.
T6841 9380-9382 , denotes ,
T6842 9382-9384 NN denotes 3C
T6843 9385-9388 CC denotes and
T6844 9389-9391 NN denotes 3D
T6845 9391-9392 -RRB- denotes )
T6846 9392-9393 . denotes .
T6847 9393-9621 sentence denotes However, (-/-) mice fell more quickly from the rod than (+/+) mice at 5, 10 and 15 rpm [5 rpm: F (1, 27.3) = 17.51, p = 0.0002; 10 rpm: F (1, 22) = 11.05, p = 0.003; 15 rpm: F (1, 22) = 19.22, p = 0.0002] (Figs. 3B, 3C and 3D).
T6848 9394-9401 RB denotes However
T6849 9414-9418 VBD denotes fell
T6850 9401-9403 , denotes ,
T6851 9403-9404 -LRB- denotes (
T6852 9409-9413 NNS denotes mice
T6853 9404-9405 SYM denotes -
T6854 9406-9407 SYM denotes -
T6855 9405-9406 HYPH denotes /
T6856 9407-9408 -RRB- denotes )
T6857 9419-9423 RBR denotes more
T6858 9424-9431 RB denotes quickly
T6859 9432-9436 IN denotes from
T6860 9437-9440 DT denotes the
T6861 9441-9444 NN denotes rod
T6862 9445-9449 IN denotes than
T6863 9450-9451 -LRB- denotes (
T6864 9451-9452 SYM denotes +
T6865 9453-9454 SYM denotes +
T6866 9452-9453 HYPH denotes /
T6867 9456-9460 NNS denotes mice
T6868 9454-9455 -RRB- denotes )
T6869 9461-9463 IN denotes at
T6870 9464-9465 CD denotes 5
T6871 9477-9480 NN denotes rpm
T6872 9465-9467 , denotes ,
T6873 9467-9469 CD denotes 10
T6874 9470-9473 CC denotes and
T6875 9474-9476 CD denotes 15
T6876 9481-9482 -LRB- denotes [
T6877 9591-9597 CD denotes 0.0002
T6878 9482-9483 CD denotes 5
T6879 9484-9487 NN denotes rpm
T6880 9514-9520 CD denotes 0.0002
T6881 9487-9489 : denotes :
T6882 9489-9490 NN denotes F
T6883 9503-9508 CD denotes 17.51
T6884 9491-9492 -LRB- denotes (
T6885 9492-9493 CD denotes 1
T6886 9493-9495 , denotes ,
T6887 9495-9499 CD denotes 27.3
T6888 9499-9500 -RRB- denotes )
T6889 9501-9502 SYM denotes =
T6890 9508-9510 , denotes ,
T6891 9510-9511 NN denotes p
T6892 9512-9513 SYM denotes =
T6893 9520-9521 : denotes ;
T6894 9522-9524 CD denotes 10
T6895 9525-9528 NN denotes rpm
T6896 9553-9558 CD denotes 0.003
T6897 9528-9530 : denotes :
T6898 9530-9531 NN denotes F
T6899 9542-9547 CD denotes 11.05
T6900 9532-9533 -LRB- denotes (
T6901 9533-9534 CD denotes 1
T6902 9534-9536 , denotes ,
T6903 9536-9538 CD denotes 22
T6904 9538-9539 -RRB- denotes )
T6905 9540-9541 SYM denotes =
T6906 9547-9549 , denotes ,
T6907 9549-9550 NN denotes p
T6908 9551-9552 SYM denotes =
T6909 9558-9559 : denotes ;
T6910 9560-9562 CD denotes 15
T6911 9563-9566 NN denotes rpm
T6912 9566-9568 : denotes :
T6913 9568-9569 NN denotes F
T6914 9580-9585 CD denotes 19.22
T6915 9570-9571 -LRB- denotes (
T6916 9571-9572 CD denotes 1
T6917 9572-9574 , denotes ,
T6918 9574-9576 CD denotes 22
T6919 9576-9577 -RRB- denotes )
T6920 9578-9579 SYM denotes =
T6921 9585-9587 , denotes ,
T6922 9587-9588 NN denotes p
T6923 9589-9590 SYM denotes =
T6924 9597-9598 -RRB- denotes ]
T6925 9599-9600 -LRB- denotes (
T6926 9606-9608 NN denotes 3B
T6927 9600-9605 NNS denotes Figs.
T6928 9608-9610 , denotes ,
T6929 9610-9612 NN denotes 3C
T6930 9613-9616 CC denotes and
T6931 9617-9619 NN denotes 3D
T6932 9619-9620 -RRB- denotes )
T6933 9620-9621 . denotes .
T6934 9621-9867 sentence denotes The retention time was not significantly improved in (-/-) mice across trials of training at 5, 10 and 15 rpm [5 rpm: F (3, 15.3) = 2.05, p = 0.15; 10 rpm: F (7, 11) = 2.61, p = 0.07; 15 rpm: F (19, 26.6) = 1.57, p = 0.14] (Figs. 3B, 3C and 3D).
T6935 9622-9625 DT denotes The
T6936 9636-9640 NN denotes time
T6937 9626-9635 NN denotes retention
T6938 9663-9671 VBN denotes improved
T6939 9641-9644 VBD denotes was
T6940 9645-9648 RB denotes not
T6941 9649-9662 RB denotes significantly
T6942 9672-9674 IN denotes in
T6943 9675-9676 -LRB- denotes (
T6944 9681-9685 NNS denotes mice
T6945 9676-9677 SYM denotes -
T6946 9678-9679 SYM denotes -
T6947 9677-9678 HYPH denotes /
T6948 9679-9680 -RRB- denotes )
T6949 9686-9692 IN denotes across
T6950 9693-9699 NNS denotes trials
T6951 9700-9702 IN denotes of
T6952 9703-9711 NN denotes training
T6953 9712-9714 IN denotes at
T6954 9715-9716 CD denotes 5
T6955 9728-9731 NN denotes rpm
T6956 9716-9718 , denotes ,
T6957 9718-9720 CD denotes 10
T6958 9721-9724 CC denotes and
T6959 9725-9727 CD denotes 15
T6960 9732-9733 -LRB- denotes [
T6961 9839-9843 CD denotes 0.14
T6962 9733-9734 CD denotes 5
T6963 9735-9738 NN denotes rpm
T6964 9764-9768 CD denotes 0.15
T6965 9738-9740 : denotes :
T6966 9740-9741 NN denotes F
T6967 9754-9758 CD denotes 2.05
T6968 9742-9743 -LRB- denotes (
T6969 9743-9744 CD denotes 3
T6970 9744-9746 , denotes ,
T6971 9746-9750 CD denotes 15.3
T6972 9750-9751 -RRB- denotes )
T6973 9752-9753 SYM denotes =
T6974 9758-9760 , denotes ,
T6975 9760-9761 NN denotes p
T6976 9762-9763 SYM denotes =
T6977 9768-9769 : denotes ;
T6978 9770-9772 CD denotes 10
T6979 9773-9776 NN denotes rpm
T6980 9800-9804 CD denotes 0.07
T6981 9776-9778 : denotes :
T6982 9778-9779 NN denotes F
T6983 9790-9794 CD denotes 2.61
T6984 9780-9781 -LRB- denotes (
T6985 9781-9782 CD denotes 7
T6986 9782-9784 , denotes ,
T6987 9784-9786 CD denotes 11
T6988 9786-9787 -RRB- denotes )
T6989 9788-9789 SYM denotes =
T6990 9794-9796 , denotes ,
T6991 9796-9797 NN denotes p
T6992 9798-9799 SYM denotes =
T6993 9804-9805 : denotes ;
T6994 9806-9808 CD denotes 15
T6995 9809-9812 NN denotes rpm
T6996 9812-9814 : denotes :
T6997 9814-9815 NN denotes F
T6998 9829-9833 CD denotes 1.57
T6999 9816-9817 -LRB- denotes (
T7000 9817-9819 CD denotes 19
T7001 9819-9821 , denotes ,
T7002 9821-9825 CD denotes 26.6
T7003 9825-9826 -RRB- denotes )
T7004 9827-9828 SYM denotes =
T7005 9833-9835 , denotes ,
T7006 9835-9836 NN denotes p
T7007 9837-9838 SYM denotes =
T7008 9843-9844 -RRB- denotes ]
T7009 9845-9846 -LRB- denotes (
T7010 9852-9854 NN denotes 3B
T7011 9846-9851 NNS denotes Figs.
T7012 9854-9856 , denotes ,
T7013 9856-9858 NN denotes 3C
T7014 9859-9862 CC denotes and
T7015 9863-9865 NN denotes 3D
T7016 9865-9866 -RRB- denotes )
T7017 9866-9867 . denotes .
T7018 9867-9976 sentence denotes In a traction test, (-/-) mice showed a high grip strength similar to that of (+/+) and (+/-) mice (Fig. 4).
T7019 9868-9870 IN denotes In
T7020 9899-9905 VBD denotes showed
T7021 9871-9872 DT denotes a
T7022 9882-9886 NN denotes test
T7023 9873-9881 NN denotes traction
T7024 9886-9888 , denotes ,
T7025 9888-9889 -LRB- denotes (
T7026 9894-9898 NNS denotes mice
T7027 9889-9890 SYM denotes -
T7028 9891-9892 SYM denotes -
T7029 9890-9891 HYPH denotes /
T7030 9892-9893 -RRB- denotes )
T7031 9906-9907 DT denotes a
T7032 9918-9926 NN denotes strength
T7033 9908-9912 JJ denotes high
T7034 9913-9917 NN denotes grip
T7035 9927-9934 JJ denotes similar
T7036 9935-9937 IN denotes to
T7037 9938-9942 DT denotes that
T7038 9943-9945 IN denotes of
T7039 9946-9947 -LRB- denotes (
T7040 9962-9966 NNS denotes mice
T7041 9947-9948 SYM denotes +
T7042 9949-9950 SYM denotes +
T7043 9948-9949 HYPH denotes /
T7044 9950-9951 -RRB- denotes )
T7045 9952-9955 CC denotes and
T7046 9956-9957 -LRB- denotes (
T7047 9959-9960 SYM denotes -
T7048 9957-9958 SYM denotes +
T7049 9958-9959 HYPH denotes /
T7050 9960-9961 -RRB- denotes )
T7051 9967-9968 -LRB- denotes (
T7052 9968-9972 NN denotes Fig.
T7053 9973-9974 CD denotes 4
T7054 9974-9975 -RRB- denotes )
T7055 9975-9976 . denotes .
T7056 9976-10087 sentence denotes The hanging score and time of (-/-) mice were also similar to those of (+/+) and (+/-) mice (Figs. 5A and 5B).
T7057 9977-9980 DT denotes The
T7058 9989-9994 NN denotes score
T7059 9981-9988 VBG denotes hanging
T7060 10018-10022 VBD denotes were
T7061 9995-9998 CC denotes and
T7062 9999-10003 NN denotes time
T7063 10004-10006 IN denotes of
T7064 10007-10008 -LRB- denotes (
T7065 10013-10017 NNS denotes mice
T7066 10008-10009 SYM denotes -
T7067 10010-10011 SYM denotes -
T7068 10009-10010 HYPH denotes /
T7069 10011-10012 -RRB- denotes )
T7070 10023-10027 RB denotes also
T7071 10028-10035 JJ denotes similar
T7072 10036-10038 IN denotes to
T7073 10039-10044 DT denotes those
T7074 10045-10047 IN denotes of
T7075 10048-10049 -LRB- denotes (
T7076 10064-10068 NNS denotes mice
T7077 10049-10050 SYM denotes +
T7078 10051-10052 SYM denotes +
T7079 10050-10051 HYPH denotes /
T7080 10052-10053 -RRB- denotes )
T7081 10054-10057 CC denotes and
T7082 10058-10059 -LRB- denotes (
T7083 10061-10062 SYM denotes -
T7084 10059-10060 SYM denotes +
T7085 10060-10061 HYPH denotes /
T7086 10062-10063 -RRB- denotes )
T7087 10069-10070 -LRB- denotes (
T7088 10076-10078 NN denotes 5A
T7089 10070-10075 NNS denotes Figs.
T7090 10079-10082 CC denotes and
T7091 10083-10085 NN denotes 5B
T7092 10085-10086 -RRB- denotes )
T7093 10086-10087 . denotes .
T7094 10087-10244 sentence denotes A footprint test did not reveal any abnormalities in walking patterns, including stride length and step width, as a function of genotypes (Figs. 6A and 6B).
T7095 10088-10089 DT denotes A
T7096 10100-10104 NN denotes test
T7097 10090-10099 NN denotes footprint
T7098 10113-10119 VB denotes reveal
T7099 10105-10108 VBD denotes did
T7100 10109-10112 RB denotes not
T7101 10120-10123 DT denotes any
T7102 10124-10137 NNS denotes abnormalities
T7103 10138-10140 IN denotes in
T7104 10141-10148 VBG denotes walking
T7105 10149-10157 NNS denotes patterns
T7106 10157-10159 , denotes ,
T7107 10159-10168 VBG denotes including
T7108 10169-10175 NN denotes stride
T7109 10176-10182 NN denotes length
T7110 10183-10186 CC denotes and
T7111 10187-10191 NN denotes step
T7112 10192-10197 NN denotes width
T7113 10197-10199 , denotes ,
T7114 10199-10201 IN denotes as
T7115 10202-10203 DT denotes a
T7116 10204-10212 NN denotes function
T7117 10213-10215 IN denotes of
T7118 10216-10225 NNS denotes genotypes
T7119 10226-10227 -LRB- denotes (
T7120 10233-10235 NN denotes 6A
T7121 10227-10232 NNS denotes Figs.
T7122 10236-10239 CC denotes and
T7123 10240-10242 NN denotes 6B
T7124 10242-10243 -RRB- denotes )
T7125 10243-10244 . denotes .
T9981 10257-10259 IN denotes In
T9982 10282-10290 VBD denotes examined
T9983 10260-10263 DT denotes the
T9984 10272-10277 NN denotes study
T9985 10264-10271 JJ denotes present
T9986 10277-10279 , denotes ,
T9987 10279-10281 PRP denotes we
T9988 10291-10294 DT denotes the
T9989 10295-10303 NN denotes function
T9990 10304-10306 IN denotes of
T9991 10307-10313 NN denotes ADAM11
T9992 10314-10316 IN denotes by
T9993 10317-10327 VBG denotes generating
T9994 10328-10332 NNS denotes mice
T9995 10333-10337 WDT denotes that
T9996 10338-10344 VBD denotes lacked
T9997 10345-10348 DT denotes the
T9998 10356-10360 NN denotes gene
T9999 10349-10355 NN denotes Adam11
T10000 10360-10361 . denotes .
T10001 10361-10501 sentence denotes It has been reported that the Adam11 gene is expressed in the brain, heart, liver and testis, as manifested in Northern blot analysis [19].
T10002 10362-10364 PRP denotes It
T10003 10374-10382 VBN denotes reported
T10004 10365-10368 VBZ denotes has
T10005 10369-10373 VBN denotes been
T10006 10383-10387 IN denotes that
T10007 10407-10416 VBN denotes expressed
T10008 10388-10391 DT denotes the
T10009 10399-10403 NN denotes gene
T10010 10392-10398 NN denotes Adam11
T10011 10404-10406 VBZ denotes is
T10012 10417-10419 IN denotes in
T10013 10420-10423 DT denotes the
T10014 10424-10429 NN denotes brain
T10015 10429-10431 , denotes ,
T10016 10431-10436 NN denotes heart
T10017 10436-10438 , denotes ,
T10018 10438-10443 NN denotes liver
T10019 10444-10447 CC denotes and
T10020 10448-10454 NN denotes testis
T10021 10454-10456 , denotes ,
T10022 10456-10458 IN denotes as
T10023 10459-10469 VBN denotes manifested
T10024 10470-10472 IN denotes in
T10025 10473-10481 NNP denotes Northern
T10026 10482-10486 NN denotes blot
T10027 10487-10495 NN denotes analysis
T10028 10496-10497 -LRB- denotes [
T10029 10497-10499 CD denotes 19
T10030 10499-10500 -RRB- denotes ]
T10031 10500-10501 . denotes .
T10032 10501-10675 sentence denotes Interestingly, ADAM11-deficient mice appeared normal and survived more than one year without apparent histological abnormality, including the brain, heart, liver and testis.
T10033 10502-10515 RB denotes Interestingly
T10034 10539-10547 VBD denotes appeared
T10035 10515-10517 , denotes ,
T10036 10517-10523 NN denotes ADAM11
T10037 10524-10533 JJ denotes deficient
T10038 10523-10524 HYPH denotes -
T10039 10534-10538 NNS denotes mice
T10040 10548-10554 JJ denotes normal
T10041 10555-10558 CC denotes and
T10042 10559-10567 VBD denotes survived
T10043 10568-10572 JJR denotes more
T10044 10578-10581 CD denotes one
T10045 10573-10577 IN denotes than
T10046 10582-10586 NN denotes year
T10047 10587-10594 IN denotes without
T10048 10595-10603 JJ denotes apparent
T10049 10617-10628 NN denotes abnormality
T10050 10604-10616 JJ denotes histological
T10051 10628-10630 , denotes ,
T10052 10630-10639 VBG denotes including
T10053 10640-10643 DT denotes the
T10054 10644-10649 NN denotes brain
T10055 10649-10651 , denotes ,
T10056 10651-10656 NN denotes heart
T10057 10656-10658 , denotes ,
T10058 10658-10663 NN denotes liver
T10059 10664-10667 CC denotes and
T10060 10668-10674 NN denotes testis
T10061 10674-10675 . denotes .
T10062 10675-10783 sentence denotes The expression patterns of the Adam11 gene in the brain have been studied using in situ hybridisation [25].
T10063 10676-10679 DT denotes The
T10064 10691-10699 NNS denotes patterns
T10065 10680-10690 NN denotes expression
T10066 10742-10749 VBN denotes studied
T10067 10700-10702 IN denotes of
T10068 10703-10706 DT denotes the
T10069 10714-10718 NN denotes gene
T10070 10707-10713 NN denotes Adam11
T10071 10719-10721 IN denotes in
T10072 10722-10725 DT denotes the
T10073 10726-10731 NN denotes brain
T10074 10732-10736 VBP denotes have
T10075 10737-10741 VBN denotes been
T10076 10750-10755 VBG denotes using
T10077 10756-10758 FW denotes in
T10078 10759-10763 FW denotes situ
T10079 10764-10777 NN denotes hybridisation
T10080 10778-10779 -LRB- denotes [
T10081 10779-10781 CD denotes 25
T10082 10781-10782 -RRB- denotes ]
T10083 10782-10783 . denotes .
T10084 10783-10870 sentence denotes This study has shown high expression of ADAM11 mRNA in the hippocampus and cerebellum.
T10085 10784-10788 DT denotes This
T10086 10789-10794 NN denotes study
T10087 10799-10804 VBN denotes shown
T10088 10795-10798 VBZ denotes has
T10089 10805-10809 JJ denotes high
T10090 10810-10820 NN denotes expression
T10091 10821-10823 IN denotes of
T10092 10824-10830 NN denotes ADAM11
T10093 10831-10835 NN denotes mRNA
T10094 10836-10838 IN denotes in
T10095 10839-10842 DT denotes the
T10096 10843-10854 NN denotes hippocampus
T10097 10855-10858 CC denotes and
T10098 10859-10869 NN denotes cerebellum
T10099 10869-10870 . denotes .
T10100 10870-11020 sentence denotes We therefore focused on examining the hippocampus- and cerebellum-dependent behavioural tests to study the functions of ADAM11 in the nervous system.
T10101 10871-10873 PRP denotes We
T10102 10884-10891 VBD denotes focused
T10103 10874-10883 RB denotes therefore
T10104 10892-10894 IN denotes on
T10105 10895-10904 VBG denotes examining
T10106 10905-10908 DT denotes the
T10107 10959-10964 NNS denotes tests
T10108 10909-10920 NN denotes hippocampus
T10109 10937-10946 JJ denotes dependent
T10110 10920-10921 HYPH denotes -
T10111 10922-10925 CC denotes and
T10112 10926-10936 NN denotes cerebellum
T10113 10936-10937 HYPH denotes -
T10114 10947-10958 JJ denotes behavioural
T10115 10965-10967 TO denotes to
T10116 10968-10973 VB denotes study
T10117 10974-10977 DT denotes the
T10118 10978-10987 NNS denotes functions
T10119 10988-10990 IN denotes of
T10120 10991-10997 NN denotes ADAM11
T10121 10998-11000 IN denotes in
T10122 11001-11004 DT denotes the
T10123 11013-11019 NN denotes system
T10124 11005-11012 JJ denotes nervous
T10125 11019-11020 . denotes .
T10126 11020-11250 sentence denotes It is widely accepted that the hippocampus is involved in the performance of the hidden platform version of the water maze test, since lesions of the hippocampal pathways lead to a severe impairment of learning in this task [29].
T10127 11021-11023 PRP denotes It
T10128 11034-11042 VBN denotes accepted
T10129 11024-11026 VBZ denotes is
T10130 11027-11033 RB denotes widely
T10131 11043-11047 IN denotes that
T10132 11067-11075 VBN denotes involved
T10133 11048-11051 DT denotes the
T10134 11052-11063 NN denotes hippocampus
T10135 11064-11066 VBZ denotes is
T10136 11076-11078 IN denotes in
T10137 11079-11082 DT denotes the
T10138 11083-11094 NN denotes performance
T10139 11095-11097 IN denotes of
T10140 11098-11101 DT denotes the
T10141 11118-11125 NN denotes version
T10142 11102-11108 JJ denotes hidden
T10143 11109-11117 NN denotes platform
T10144 11126-11128 IN denotes of
T10145 11129-11132 DT denotes the
T10146 11144-11148 NN denotes test
T10147 11133-11138 NN denotes water
T10148 11139-11143 NN denotes maze
T10149 11148-11150 , denotes ,
T10150 11150-11155 IN denotes since
T10151 11192-11196 VBP denotes lead
T10152 11156-11163 NNS denotes lesions
T10153 11164-11166 IN denotes of
T10154 11167-11170 DT denotes the
T10155 11183-11191 NNS denotes pathways
T10156 11171-11182 JJ denotes hippocampal
T10157 11197-11199 IN denotes to
T10158 11200-11201 DT denotes a
T10159 11209-11219 NN denotes impairment
T10160 11202-11208 JJ denotes severe
T10161 11220-11222 IN denotes of
T10162 11223-11231 VBG denotes learning
T10163 11232-11234 IN denotes in
T10164 11235-11239 DT denotes this
T10165 11240-11244 NN denotes task
T10166 11245-11246 -LRB- denotes [
T10167 11246-11248 CD denotes 29
T10168 11248-11249 -RRB- denotes ]
T10169 11249-11250 . denotes .
T10170 11250-11361 sentence denotes In the hidden platform task, ADAM11-deficient mice needed more time to reach the platform than wild-type mice.
T10171 11251-11253 IN denotes In
T10172 11302-11308 VBD denotes needed
T10173 11254-11257 DT denotes the
T10174 11274-11278 NN denotes task
T10175 11258-11264 JJ denotes hidden
T10176 11265-11273 NN denotes platform
T10177 11278-11280 , denotes ,
T10178 11280-11286 NN denotes ADAM11
T10179 11287-11296 JJ denotes deficient
T10180 11286-11287 HYPH denotes -
T10181 11297-11301 NNS denotes mice
T10182 11309-11313 JJR denotes more
T10183 11314-11318 NN denotes time
T10184 11319-11321 TO denotes to
T10185 11322-11327 VB denotes reach
T10186 11328-11331 DT denotes the
T10187 11332-11340 NN denotes platform
T10188 11341-11345 IN denotes than
T10189 11346-11350 JJ denotes wild
T10190 11351-11355 NN denotes type
T10191 11350-11351 HYPH denotes -
T10192 11356-11360 NNS denotes mice
T10193 11360-11361 . denotes .
T10194 11361-11509 sentence denotes Spatial learning was also assessed using a probe trial, in which the platform was removed from the pool on the day following nine days of training.
T10195 11362-11369 JJ denotes Spatial
T10196 11370-11378 NN denotes learning
T10197 11388-11396 VBN denotes assessed
T10198 11379-11382 VBD denotes was
T10199 11383-11387 RB denotes also
T10200 11397-11402 VBG denotes using
T10201 11403-11404 DT denotes a
T10202 11411-11416 NN denotes trial
T10203 11405-11410 NN denotes probe
T10204 11416-11418 , denotes ,
T10205 11418-11420 IN denotes in
T10206 11444-11451 VBN denotes removed
T10207 11421-11426 WDT denotes which
T10208 11427-11430 DT denotes the
T10209 11431-11439 NN denotes platform
T10210 11440-11443 VBD denotes was
T10211 11452-11456 IN denotes from
T10212 11457-11460 DT denotes the
T10213 11461-11465 NN denotes pool
T10214 11466-11468 IN denotes on
T10215 11469-11472 DT denotes the
T10216 11473-11476 NN denotes day
T10217 11477-11486 VBG denotes following
T10218 11487-11491 CD denotes nine
T10219 11492-11496 NNS denotes days
T10220 11497-11499 IN denotes of
T10221 11500-11508 NN denotes training
T10222 11508-11509 . denotes .
T10223 11509-11634 sentence denotes The wild-type mice spent significantly more time searching for the platform in the target quadrant than the other quadrants.
T10224 11510-11513 DT denotes The
T10225 11524-11528 NNS denotes mice
T10226 11514-11518 JJ denotes wild
T10227 11519-11523 NN denotes type
T10228 11518-11519 HYPH denotes -
T10229 11529-11534 VBD denotes spent
T10230 11535-11548 RB denotes significantly
T10231 11549-11553 JJR denotes more
T10232 11554-11558 NN denotes time
T10233 11559-11568 VBG denotes searching
T10234 11569-11572 IN denotes for
T10235 11573-11576 DT denotes the
T10236 11577-11585 NN denotes platform
T10237 11586-11588 IN denotes in
T10238 11589-11592 DT denotes the
T10239 11600-11608 NN denotes quadrant
T10240 11593-11599 NN denotes target
T10241 11609-11613 IN denotes than
T10242 11614-11617 DT denotes the
T10243 11624-11633 NNS denotes quadrants
T10244 11618-11623 JJ denotes other
T10245 11633-11634 . denotes .
T10246 11634-11716 sentence denotes However, ADAM11-deficient mice did not search selectively in the target quadrant.
T10247 11635-11642 RB denotes However
T10248 11674-11680 VB denotes search
T10249 11642-11644 , denotes ,
T10250 11644-11650 NN denotes ADAM11
T10251 11651-11660 JJ denotes deficient
T10252 11650-11651 HYPH denotes -
T10253 11661-11665 NNS denotes mice
T10254 11666-11669 VBD denotes did
T10255 11670-11673 RB denotes not
T10256 11681-11692 RB denotes selectively
T10257 11693-11695 IN denotes in
T10258 11696-11699 DT denotes the
T10259 11707-11715 NN denotes quadrant
T10260 11700-11706 NN denotes target
T10261 11715-11716 . denotes .
T10262 11716-11873 sentence denotes On the other hand, in the visible platform version, in which the motor ability and visual acuity of the mouse are tested, ADAM11-defieient mice were normal.
T10263 11717-11719 IN denotes On
T10264 11861-11865 VBD denotes were
T10265 11720-11723 DT denotes the
T10266 11730-11734 NN denotes hand
T10267 11724-11729 JJ denotes other
T10268 11734-11736 , denotes ,
T10269 11736-11738 IN denotes in
T10270 11739-11742 DT denotes the
T10271 11760-11767 NN denotes version
T10272 11743-11750 JJ denotes visible
T10273 11751-11759 NN denotes platform
T10274 11767-11769 , denotes ,
T10275 11769-11771 IN denotes in
T10276 11831-11837 VBN denotes tested
T10277 11772-11777 WDT denotes which
T10278 11778-11781 DT denotes the
T10279 11788-11795 NN denotes ability
T10280 11782-11787 JJ denotes motor
T10281 11796-11799 CC denotes and
T10282 11800-11806 JJ denotes visual
T10283 11807-11813 NN denotes acuity
T10284 11814-11816 IN denotes of
T10285 11817-11820 DT denotes the
T10286 11821-11826 NN denotes mouse
T10287 11827-11830 VBP denotes are
T10288 11837-11839 , denotes ,
T10289 11839-11845 NN denotes ADAM11
T10290 11846-11855 JJ denotes defieient
T10291 11845-11846 HYPH denotes -
T10292 11856-11860 NNS denotes mice
T10293 11866-11872 JJ denotes normal
T10294 11872-11873 . denotes .
T10295 11873-11962 sentence denotes These results indicated that ADAM11-deficient mice showed a spatial learning impairment.
T10296 11874-11879 DT denotes These
T10297 11880-11887 NNS denotes results
T10298 11888-11897 VBD denotes indicated
T10299 11898-11902 IN denotes that
T10300 11925-11931 VBD denotes showed
T10301 11903-11909 NN denotes ADAM11
T10302 11910-11919 JJ denotes deficient
T10303 11909-11910 HYPH denotes -
T10304 11920-11924 NNS denotes mice
T10305 11932-11933 DT denotes a
T10306 11951-11961 NN denotes impairment
T10307 11934-11941 JJ denotes spatial
T10308 11942-11950 NN denotes learning
T10309 11961-11962 . denotes .
T10310 11962-12132 sentence denotes The cerebellum is in charge of the smooth coordination of somatic motor activity, regulation of muscle tone, and mechanisms that influence and maintain equilibrium [30].
T10311 11963-11966 DT denotes The
T10312 11967-11977 NN denotes cerebellum
T10313 11978-11980 VBZ denotes is
T10314 11981-11983 IN denotes in
T10315 11984-11990 NN denotes charge
T10316 11991-11993 IN denotes of
T10317 11994-11997 DT denotes the
T10318 12005-12017 NN denotes coordination
T10319 11998-12004 JJ denotes smooth
T10320 12018-12020 IN denotes of
T10321 12021-12028 JJ denotes somatic
T10322 12035-12043 NN denotes activity
T10323 12029-12034 NN denotes motor
T10324 12043-12045 , denotes ,
T10325 12045-12055 NN denotes regulation
T10326 12056-12058 IN denotes of
T10327 12059-12065 NN denotes muscle
T10328 12066-12070 NN denotes tone
T10329 12070-12072 , denotes ,
T10330 12072-12075 CC denotes and
T10331 12076-12086 NNS denotes mechanisms
T10332 12087-12091 WDT denotes that
T10333 12092-12101 VBP denotes influence
T10334 12102-12105 CC denotes and
T10335 12106-12114 VBP denotes maintain
T10336 12115-12126 NN denotes equilibrium
T10337 12127-12128 -LRB- denotes [
T10338 12128-12130 CD denotes 30
T10339 12130-12131 -RRB- denotes ]
T10340 12131-12132 . denotes .
T10341 12132-12399 sentence denotes It is widely accepted that the cerebellum is involved in the performance of the rotating rod task, since mice with structural abnormalities in the cerebellum [31] or with disruptions in genes enriched in the cerebellum [32] exhibit performance deficits in this task.
T10342 12133-12135 PRP denotes It
T10343 12146-12154 VBN denotes accepted
T10344 12136-12138 VBZ denotes is
T10345 12139-12145 RB denotes widely
T10346 12155-12159 IN denotes that
T10347 12178-12186 VBN denotes involved
T10348 12160-12163 DT denotes the
T10349 12164-12174 NN denotes cerebellum
T10350 12175-12177 VBZ denotes is
T10351 12187-12189 IN denotes in
T10352 12190-12193 DT denotes the
T10353 12194-12205 NN denotes performance
T10354 12206-12208 IN denotes of
T10355 12209-12212 DT denotes the
T10356 12226-12230 NN denotes task
T10357 12213-12221 VBG denotes rotating
T10358 12222-12225 NN denotes rod
T10359 12230-12232 , denotes ,
T10360 12232-12237 IN denotes since
T10361 12357-12364 VBP denotes exhibit
T10362 12238-12242 NNS denotes mice
T10363 12243-12247 IN denotes with
T10364 12248-12258 JJ denotes structural
T10365 12259-12272 NNS denotes abnormalities
T10366 12273-12275 IN denotes in
T10367 12276-12279 DT denotes the
T10368 12280-12290 NN denotes cerebellum
T10369 12291-12292 -LRB- denotes [
T10370 12292-12294 CD denotes 31
T10371 12294-12295 -RRB- denotes ]
T10372 12296-12298 CC denotes or
T10373 12299-12303 IN denotes with
T10374 12304-12315 NNS denotes disruptions
T10375 12316-12318 IN denotes in
T10376 12319-12324 NNS denotes genes
T10377 12325-12333 VBN denotes enriched
T10378 12334-12336 IN denotes in
T10379 12337-12340 DT denotes the
T10380 12341-12351 NN denotes cerebellum
T10381 12352-12353 -LRB- denotes [
T10382 12353-12355 CD denotes 32
T10383 12355-12356 -RRB- denotes ]
T10384 12365-12376 NN denotes performance
T10385 12377-12385 NNS denotes deficits
T10386 12386-12388 IN denotes in
T10387 12389-12393 DT denotes this
T10388 12394-12398 NN denotes task
T10389 12398-12399 . denotes .
T10390 12399-12658 sentence denotes In the rotating rod test in this study, although the retention time of ADAM11-deficient mice on the rod was not different from wild-type mice at 0 rpm (stationary), ADAM11-deficient mice fell more quickly from the rod than wild-type mice at 5, 10 and 15 rpm.
T10391 12400-12402 IN denotes In
T10392 12587-12591 VBD denotes fell
T10393 12403-12406 DT denotes the
T10394 12420-12424 NN denotes test
T10395 12407-12415 VBG denotes rotating
T10396 12416-12419 NN denotes rod
T10397 12425-12427 IN denotes in
T10398 12428-12432 DT denotes this
T10399 12433-12438 NN denotes study
T10400 12438-12440 , denotes ,
T10401 12440-12448 IN denotes although
T10402 12504-12507 VBD denotes was
T10403 12449-12452 DT denotes the
T10404 12463-12467 NN denotes time
T10405 12453-12462 NN denotes retention
T10406 12468-12470 IN denotes of
T10407 12471-12477 NN denotes ADAM11
T10408 12478-12487 JJ denotes deficient
T10409 12477-12478 HYPH denotes -
T10410 12488-12492 NNS denotes mice
T10411 12493-12495 IN denotes on
T10412 12496-12499 DT denotes the
T10413 12500-12503 NN denotes rod
T10414 12508-12511 RB denotes not
T10415 12512-12521 JJ denotes different
T10416 12522-12526 IN denotes from
T10417 12527-12531 JJ denotes wild
T10418 12532-12536 NN denotes type
T10419 12531-12532 HYPH denotes -
T10420 12537-12541 NNS denotes mice
T10421 12542-12544 IN denotes at
T10422 12545-12546 CD denotes 0
T10423 12547-12550 NN denotes rpm
T10424 12551-12552 -LRB- denotes (
T10425 12552-12562 JJ denotes stationary
T10426 12562-12563 -RRB- denotes )
T10427 12563-12565 , denotes ,
T10428 12565-12571 NN denotes ADAM11
T10429 12572-12581 JJ denotes deficient
T10430 12571-12572 HYPH denotes -
T10431 12582-12586 NNS denotes mice
T10432 12592-12596 RBR denotes more
T10433 12597-12604 RB denotes quickly
T10434 12605-12609 IN denotes from
T10435 12610-12613 DT denotes the
T10436 12614-12617 NN denotes rod
T10437 12618-12622 IN denotes than
T10438 12623-12627 JJ denotes wild
T10439 12628-12632 NN denotes type
T10440 12627-12628 HYPH denotes -
T10441 12633-12637 NNS denotes mice
T10442 12638-12640 IN denotes at
T10443 12641-12642 CD denotes 5
T10444 12654-12657 NN denotes rpm
T10445 12642-12644 , denotes ,
T10446 12644-12646 CD denotes 10
T10447 12647-12650 CC denotes and
T10448 12651-12653 CD denotes 15
T10449 12657-12658 . denotes .
T10450 12658-12746 sentence denotes These results indicate that ADAM11-deficient mice have a deficit in motor coordination.
T10451 12659-12664 DT denotes These
T10452 12665-12672 NNS denotes results
T10453 12673-12681 VBP denotes indicate
T10454 12682-12686 IN denotes that
T10455 12709-12713 VBP denotes have
T10456 12687-12693 NN denotes ADAM11
T10457 12694-12703 JJ denotes deficient
T10458 12693-12694 HYPH denotes -
T10459 12704-12708 NNS denotes mice
T10460 12714-12715 DT denotes a
T10461 12716-12723 NN denotes deficit
T10462 12724-12726 IN denotes in
T10463 12727-12732 NN denotes motor
T10464 12733-12745 NN denotes coordination
T10465 12745-12746 . denotes .
T10466 12746-12884 sentence denotes On the other hand, in the visual platform version of the water maze task, motor ability for swimming in ADAM11-deficient mice was normal.
T10467 12747-12749 IN denotes On
T10468 12873-12876 VBD denotes was
T10469 12750-12753 DT denotes the
T10470 12760-12764 NN denotes hand
T10471 12754-12759 JJ denotes other
T10472 12764-12766 , denotes ,
T10473 12766-12768 IN denotes in
T10474 12769-12772 DT denotes the
T10475 12789-12796 NN denotes version
T10476 12773-12779 JJ denotes visual
T10477 12780-12788 NN denotes platform
T10478 12797-12799 IN denotes of
T10479 12800-12803 DT denotes the
T10480 12815-12819 NN denotes task
T10481 12804-12809 NN denotes water
T10482 12810-12814 NN denotes maze
T10483 12819-12821 , denotes ,
T10484 12821-12826 NN denotes motor
T10485 12827-12834 NN denotes ability
T10486 12835-12838 IN denotes for
T10487 12839-12847 NN denotes swimming
T10488 12848-12850 IN denotes in
T10489 12851-12857 NN denotes ADAM11
T10490 12858-12867 JJ denotes deficient
T10491 12857-12858 HYPH denotes -
T10492 12868-12872 NNS denotes mice
T10493 12877-12883 JJ denotes normal
T10494 12883-12884 . denotes .
T10495 12884-13012 sentence denotes These results suggested that there might be a different mechanism of motor function between swimming and the rotating rod task.
T10496 12885-12890 DT denotes These
T10497 12891-12898 NNS denotes results
T10498 12899-12908 VBD denotes suggested
T10499 12909-12913 IN denotes that
T10500 12926-12928 VB denotes be
T10501 12914-12919 EX denotes there
T10502 12920-12925 MD denotes might
T10503 12929-12930 DT denotes a
T10504 12941-12950 NN denotes mechanism
T10505 12931-12940 JJ denotes different
T10506 12951-12953 IN denotes of
T10507 12954-12959 NN denotes motor
T10508 12960-12968 NN denotes function
T10509 12969-12976 IN denotes between
T10510 12977-12985 NN denotes swimming
T10511 12986-12989 CC denotes and
T10512 12990-12993 DT denotes the
T10513 13007-13011 NN denotes task
T10514 12994-13002 VBG denotes rotating
T10515 13003-13006 NN denotes rod
T10516 13011-13012 . denotes .
T10517 13012-13177 sentence denotes It has been also reported that the cerebellum is involved in another important distinct function: learning associated with component movement (motor learning) [33].
T10518 13013-13015 PRP denotes It
T10519 13030-13038 VBN denotes reported
T10520 13016-13019 VBZ denotes has
T10521 13020-13024 VBN denotes been
T10522 13025-13029 RB denotes also
T10523 13039-13043 IN denotes that
T10524 13062-13070 VBN denotes involved
T10525 13044-13047 DT denotes the
T10526 13048-13058 NN denotes cerebellum
T10527 13059-13061 VBZ denotes is
T10528 13071-13073 IN denotes in
T10529 13074-13081 DT denotes another
T10530 13101-13109 NN denotes function
T10531 13082-13091 JJ denotes important
T10532 13092-13100 JJ denotes distinct
T10533 13109-13111 : denotes :
T10534 13111-13119 NN denotes learning
T10535 13120-13130 VBN denotes associated
T10536 13131-13135 IN denotes with
T10537 13136-13145 NN denotes component
T10538 13146-13154 NN denotes movement
T10539 13155-13156 -LRB- denotes (
T10540 13156-13161 NN denotes motor
T10541 13162-13170 NN denotes learning
T10542 13170-13171 -RRB- denotes )
T10543 13172-13173 -LRB- denotes [
T10544 13173-13175 CD denotes 33
T10545 13175-13176 -RRB- denotes ]
T10546 13176-13177 . denotes .
T10547 13177-13408 sentence denotes The retention time of synaptotagmin (Syt) IV-deficient mice on the rod was significantly shorter than wild-type mice, and they improved it approximately to the same rates as did wild-type mice during rotating rod performance [34].
T10548 13178-13181 DT denotes The
T10549 13192-13196 NN denotes time
T10550 13182-13191 NN denotes retention
T10551 13249-13252 VBD denotes was
T10552 13197-13199 IN denotes of
T10553 13200-13213 NN denotes synaptotagmin
T10554 13223-13232 JJ denotes deficient
T10555 13214-13215 -LRB- denotes (
T10556 13215-13218 NN denotes Syt
T10557 13220-13222 NN denotes IV
T10558 13218-13219 -RRB- denotes )
T10559 13222-13223 HYPH denotes -
T10560 13233-13237 NNS denotes mice
T10561 13238-13240 IN denotes on
T10562 13241-13244 DT denotes the
T10563 13245-13248 NN denotes rod
T10564 13253-13266 RB denotes significantly
T10565 13267-13274 JJR denotes shorter
T10566 13275-13279 IN denotes than
T10567 13280-13284 JJ denotes wild
T10568 13285-13289 NN denotes type
T10569 13284-13285 HYPH denotes -
T10570 13290-13294 NNS denotes mice
T10571 13294-13296 , denotes ,
T10572 13296-13299 CC denotes and
T10573 13300-13304 PRP denotes they
T10574 13305-13313 VBD denotes improved
T10575 13314-13316 PRP denotes it
T10576 13317-13330 RB denotes approximately
T10577 13331-13333 IN denotes to
T10578 13334-13337 DT denotes the
T10579 13343-13348 NNS denotes rates
T10580 13338-13342 JJ denotes same
T10581 13349-13351 IN denotes as
T10582 13352-13355 VBD denotes did
T10583 13356-13360 JJ denotes wild
T10584 13361-13365 NN denotes type
T10585 13360-13361 HYPH denotes -
T10586 13366-13370 NNS denotes mice
T10587 13371-13377 IN denotes during
T10588 13378-13386 VBG denotes rotating
T10589 13387-13390 NN denotes rod
T10590 13391-13402 NN denotes performance
T10591 13403-13404 -LRB- denotes [
T10592 13404-13406 CD denotes 34
T10593 13406-13407 -RRB- denotes ]
T10594 13407-13408 . denotes .
T10595 13408-13568 sentence denotes These data suggest the basis for the performance deficit on the rotating rod task in the Syt IV mutants is in motor coordination rather than in motor learning.
T10596 13409-13414 DT denotes These
T10597 13415-13419 NNS denotes data
T10598 13420-13427 VBP denotes suggest
T10599 13428-13431 DT denotes the
T10600 13432-13437 NN denotes basis
T10601 13513-13515 VBZ denotes is
T10602 13438-13441 IN denotes for
T10603 13442-13445 DT denotes the
T10604 13458-13465 NN denotes deficit
T10605 13446-13457 NN denotes performance
T10606 13466-13468 IN denotes on
T10607 13469-13472 DT denotes the
T10608 13486-13490 NN denotes task
T10609 13473-13481 VBG denotes rotating
T10610 13482-13485 NN denotes rod
T10611 13491-13493 IN denotes in
T10612 13494-13497 DT denotes the
T10613 13505-13512 NNS denotes mutants
T10614 13498-13501 NN denotes Syt
T10615 13502-13504 CD denotes IV
T10616 13516-13518 IN denotes in
T10617 13519-13524 NN denotes motor
T10618 13525-13537 NN denotes coordination
T10619 13538-13544 RB denotes rather
T10620 13545-13549 IN denotes than
T10621 13550-13552 IN denotes in
T10622 13553-13558 NN denotes motor
T10623 13559-13567 NN denotes learning
T10624 13567-13568 . denotes .
T10625 13568-13736 sentence denotes The results in the present study showed that ADAM11-deficient mice slightly, though not significantly, improved motor learning ability during rotating rod performance.
T10626 13569-13572 DT denotes The
T10627 13573-13580 NNS denotes results
T10628 13602-13608 VBD denotes showed
T10629 13581-13583 IN denotes in
T10630 13584-13587 DT denotes the
T10631 13596-13601 NN denotes study
T10632 13588-13595 JJ denotes present
T10633 13609-13613 IN denotes that
T10634 13672-13680 VBD denotes improved
T10635 13614-13620 NN denotes ADAM11
T10636 13621-13630 JJ denotes deficient
T10637 13620-13621 HYPH denotes -
T10638 13631-13635 NNS denotes mice
T10639 13636-13644 RB denotes slightly
T10640 13644-13646 , denotes ,
T10641 13646-13652 IN denotes though
T10642 13653-13656 RB denotes not
T10643 13657-13670 RB denotes significantly
T10644 13670-13672 , denotes ,
T10645 13681-13686 NN denotes motor
T10646 13687-13695 NN denotes learning
T10647 13696-13703 NN denotes ability
T10648 13704-13710 IN denotes during
T10649 13711-13719 VBG denotes rotating
T10650 13720-13723 NN denotes rod
T10651 13724-13735 NN denotes performance
T10652 13735-13736 . denotes .
T10653 13736-13829 sentence denotes However, the deficit of motor learning in ADAM11-deficient mice was not clear in this study.
T10654 13737-13744 RB denotes However
T10655 13801-13804 VBD denotes was
T10656 13744-13746 , denotes ,
T10657 13746-13749 DT denotes the
T10658 13750-13757 NN denotes deficit
T10659 13758-13760 IN denotes of
T10660 13761-13766 NN denotes motor
T10661 13767-13775 NN denotes learning
T10662 13776-13778 IN denotes in
T10663 13779-13785 NN denotes ADAM11
T10664 13786-13795 JJ denotes deficient
T10665 13785-13786 HYPH denotes -
T10666 13796-13800 NNS denotes mice
T10667 13805-13808 RB denotes not
T10668 13809-13814 JJ denotes clear
T10669 13815-13817 IN denotes in
T10670 13818-13822 DT denotes this
T10671 13823-13828 NN denotes study
T10672 13828-13829 . denotes .
T10673 13829-13910 sentence denotes Because they could not ride on the rotating rod, they might not learn this task.
T10674 13830-13837 IN denotes Because
T10675 13853-13857 VB denotes ride
T10676 13838-13842 PRP denotes they
T10677 13843-13848 MD denotes could
T10678 13849-13852 RB denotes not
T10679 13894-13899 VB denotes learn
T10680 13858-13860 IN denotes on
T10681 13861-13864 DT denotes the
T10682 13874-13877 NN denotes rod
T10683 13865-13873 VBG denotes rotating
T10684 13877-13879 , denotes ,
T10685 13879-13883 PRP denotes they
T10686 13884-13889 MD denotes might
T10687 13890-13893 RB denotes not
T10688 13900-13904 DT denotes this
T10689 13905-13909 NN denotes task
T10690 13909-13910 . denotes .
T10691 13910-14089 sentence denotes To examine motor learning ability in ADAM11-deficient mice in detail, we will need to use other cerebellar-dependent learning tasks, such as a classical eyelid conditioning test.
T10692 13911-13913 TO denotes To
T10693 13914-13921 VB denotes examine
T10694 13989-13993 VB denotes need
T10695 13922-13927 NN denotes motor
T10696 13928-13936 NN denotes learning
T10697 13937-13944 NN denotes ability
T10698 13945-13947 IN denotes in
T10699 13948-13954 NN denotes ADAM11
T10700 13955-13964 JJ denotes deficient
T10701 13954-13955 HYPH denotes -
T10702 13965-13969 NNS denotes mice
T10703 13970-13972 IN denotes in
T10704 13973-13979 NN denotes detail
T10705 13979-13981 , denotes ,
T10706 13981-13983 PRP denotes we
T10707 13984-13988 MD denotes will
T10708 13994-13996 TO denotes to
T10709 13997-14000 VB denotes use
T10710 14001-14006 JJ denotes other
T10711 14037-14042 NNS denotes tasks
T10712 14007-14017 JJ denotes cerebellar
T10713 14018-14027 JJ denotes dependent
T10714 14017-14018 HYPH denotes -
T10715 14028-14036 NN denotes learning
T10716 14042-14044 , denotes ,
T10717 14044-14048 JJ denotes such
T10718 14049-14051 IN denotes as
T10719 14052-14053 DT denotes a
T10720 14084-14088 NN denotes test
T10721 14054-14063 JJ denotes classical
T10722 14064-14070 NN denotes eyelid
T10723 14071-14083 VBG denotes conditioning
T10724 14088-14089 . denotes .
T10725 14089-14185 sentence denotes There was no impairment in the grip strength and wire suspension test in ADAM11-deficient mice.
T10726 14090-14095 EX denotes There
T10727 14096-14099 VBD denotes was
T10728 14100-14102 DT denotes no
T10729 14103-14113 NN denotes impairment
T10730 14114-14116 IN denotes in
T10731 14117-14120 DT denotes the
T10732 14155-14159 NN denotes test
T10733 14121-14125 NN denotes grip
T10734 14126-14134 NN denotes strength
T10735 14135-14138 CC denotes and
T10736 14139-14143 NN denotes wire
T10737 14144-14154 NN denotes suspension
T10738 14160-14162 IN denotes in
T10739 14163-14169 NN denotes ADAM11
T10740 14170-14179 JJ denotes deficient
T10741 14169-14170 HYPH denotes -
T10742 14180-14184 NNS denotes mice
T10743 14184-14185 . denotes .
T10744 14185-14422 sentence denotes Spontaneous motor activity and walking patterns of ADAM11-deficient mice were also found to be normal, suggesting that the dysfunction found in the rotating rod test was not derived from muscle weakness or other peripheral disturbances.
T10745 14186-14197 JJ denotes Spontaneous
T10746 14204-14212 NN denotes activity
T10747 14198-14203 NN denotes motor
T10748 14269-14274 VBN denotes found
T10749 14213-14216 CC denotes and
T10750 14217-14224 VBG denotes walking
T10751 14225-14233 NNS denotes patterns
T10752 14234-14236 IN denotes of
T10753 14237-14243 NN denotes ADAM11
T10754 14244-14253 JJ denotes deficient
T10755 14243-14244 HYPH denotes -
T10756 14254-14258 NNS denotes mice
T10757 14259-14263 VBD denotes were
T10758 14264-14268 RB denotes also
T10759 14275-14277 TO denotes to
T10760 14278-14280 VB denotes be
T10761 14281-14287 JJ denotes normal
T10762 14287-14289 , denotes ,
T10763 14289-14299 VBG denotes suggesting
T10764 14300-14304 IN denotes that
T10765 14360-14367 VBN denotes derived
T10766 14305-14308 DT denotes the
T10767 14309-14320 NN denotes dysfunction
T10768 14321-14326 VBN denotes found
T10769 14327-14329 IN denotes in
T10770 14330-14333 DT denotes the
T10771 14347-14351 NN denotes test
T10772 14334-14342 VBG denotes rotating
T10773 14343-14346 NN denotes rod
T10774 14352-14355 VBD denotes was
T10775 14356-14359 RB denotes not
T10776 14368-14372 IN denotes from
T10777 14373-14379 NN denotes muscle
T10778 14380-14388 NN denotes weakness
T10779 14389-14391 CC denotes or
T10780 14392-14397 JJ denotes other
T10781 14409-14421 NNS denotes disturbances
T10782 14398-14408 JJ denotes peripheral
T10783 14421-14422 . denotes .
T10784 14422-14633 sentence denotes These results suggest that limited brain sites, mainly the hippocampus and cerebellum, might contribute to the dominant phenotype, spatial learning impairment and motor discoordination in ADAM11-deficient mice.
T10785 14423-14428 DT denotes These
T10786 14429-14436 NNS denotes results
T10787 14437-14444 VBP denotes suggest
T10788 14445-14449 IN denotes that
T10789 14516-14526 VB denotes contribute
T10790 14450-14457 JJ denotes limited
T10791 14464-14469 NNS denotes sites
T10792 14458-14463 NN denotes brain
T10793 14469-14471 , denotes ,
T10794 14471-14477 RB denotes mainly
T10795 14482-14493 NN denotes hippocampus
T10796 14478-14481 DT denotes the
T10797 14494-14497 CC denotes and
T10798 14498-14508 NN denotes cerebellum
T10799 14508-14510 , denotes ,
T10800 14510-14515 MD denotes might
T10801 14527-14529 IN denotes to
T10802 14530-14533 DT denotes the
T10803 14543-14552 NN denotes phenotype
T10804 14534-14542 JJ denotes dominant
T10805 14552-14554 , denotes ,
T10806 14554-14561 JJ denotes spatial
T10807 14562-14570 NN denotes learning
T10808 14571-14581 NN denotes impairment
T10809 14582-14585 CC denotes and
T10810 14586-14591 NN denotes motor
T10811 14592-14607 NN denotes discoordination
T10812 14608-14610 IN denotes in
T10813 14611-14617 NN denotes ADAM11
T10814 14618-14627 JJ denotes deficient
T10815 14617-14618 HYPH denotes -
T10816 14628-14632 NNS denotes mice
T10817 14632-14633 . denotes .
T10818 14633-14845 sentence denotes In situ hybridisation analysis has detected Adam11 gene expression in the pyramidal cells of CA1–CA3 fields and granule cells of the dentate gyrus in the hippocampus and in granular cells in the cerebellum [25].
T10819 14634-14636 FW denotes In
T10820 14637-14641 FW denotes situ
T10821 14642-14655 NN denotes hybridisation
T10822 14656-14664 NN denotes analysis
T10823 14669-14677 VBN denotes detected
T10824 14665-14668 VBZ denotes has
T10825 14678-14684 NN denotes Adam11
T10826 14685-14689 NN denotes gene
T10827 14690-14700 NN denotes expression
T10828 14701-14703 IN denotes in
T10829 14704-14707 DT denotes the
T10830 14718-14723 NNS denotes cells
T10831 14708-14717 JJ denotes pyramidal
T10832 14724-14726 IN denotes of
T10833 14727-14730 NN denotes CA1
T10834 14735-14741 NNS denotes fields
T10835 14730-14731 SYM denotes –
T10836 14731-14734 NN denotes CA3
T10837 14742-14745 CC denotes and
T10838 14746-14753 NN denotes granule
T10839 14754-14759 NNS denotes cells
T10840 14760-14762 IN denotes of
T10841 14763-14766 DT denotes the
T10842 14775-14780 NN denotes gyrus
T10843 14767-14774 NN denotes dentate
T10844 14781-14783 IN denotes in
T10845 14784-14787 DT denotes the
T10846 14788-14799 NN denotes hippocampus
T10847 14800-14803 CC denotes and
T10848 14804-14806 IN denotes in
T10849 14807-14815 JJ denotes granular
T10850 14816-14821 NNS denotes cells
T10851 14822-14824 IN denotes in
T10852 14825-14828 DT denotes the
T10853 14829-14839 NN denotes cerebellum
T10854 14840-14841 -LRB- denotes [
T10855 14841-14843 CD denotes 25
T10856 14843-14844 -RRB- denotes ]
T10857 14844-14845 . denotes .
T10858 14845-15151 sentence denotes It is unlikely that morphological changes during development led to impairment of spatial learning and motor coordination, and morphological alterations in the cytoarchitecture of the hippocampus and cerebellum were not observed in ADAM11-deficient mice after histological investigation using HE staining.
T10859 14846-14848 PRP denotes It
T10860 14849-14851 VBZ denotes is
T10861 15066-15074 VBN denotes observed
T10862 14852-14860 JJ denotes unlikely
T10863 14861-14865 IN denotes that
T10864 14907-14910 VBD denotes led
T10865 14866-14879 JJ denotes morphological
T10866 14880-14887 NNS denotes changes
T10867 14888-14894 IN denotes during
T10868 14895-14906 NN denotes development
T10869 14911-14913 IN denotes to
T10870 14914-14924 NN denotes impairment
T10871 14925-14927 IN denotes of
T10872 14928-14935 JJ denotes spatial
T10873 14936-14944 NN denotes learning
T10874 14945-14948 CC denotes and
T10875 14949-14954 NN denotes motor
T10876 14955-14967 NN denotes coordination
T10877 14967-14969 , denotes ,
T10878 14969-14972 CC denotes and
T10879 14973-14986 JJ denotes morphological
T10880 14987-14998 NNS denotes alterations
T10881 14999-15001 IN denotes in
T10882 15002-15005 DT denotes the
T10883 15006-15022 NN denotes cytoarchitecture
T10884 15023-15025 IN denotes of
T10885 15026-15029 DT denotes the
T10886 15030-15041 NN denotes hippocampus
T10887 15042-15045 CC denotes and
T10888 15046-15056 NN denotes cerebellum
T10889 15057-15061 VBD denotes were
T10890 15062-15065 RB denotes not
T10891 15075-15077 IN denotes in
T10892 15078-15084 NN denotes ADAM11
T10893 15085-15094 JJ denotes deficient
T10894 15084-15085 HYPH denotes -
T10895 15095-15099 NNS denotes mice
T10896 15100-15105 IN denotes after
T10897 15106-15118 JJ denotes histological
T10898 15119-15132 NN denotes investigation
T10899 15133-15138 VBG denotes using
T10900 15139-15141 NN denotes HE
T10901 15142-15150 NN denotes staining
T10902 15150-15151 . denotes .
T10903 15151-15318 sentence denotes However, because it is thought that ADAM11 plays a role in neuron-neuron or neuron-glial cell interactions, a more precise morphological investigation will be needed.
T10904 15152-15159 RB denotes However
T10905 15311-15317 VBN denotes needed
T10906 15159-15161 , denotes ,
T10907 15161-15168 IN denotes because
T10908 15175-15182 VBN denotes thought
T10909 15169-15171 PRP denotes it
T10910 15172-15174 VBZ denotes is
T10911 15183-15187 IN denotes that
T10912 15195-15200 VBZ denotes plays
T10913 15188-15194 NN denotes ADAM11
T10914 15201-15202 DT denotes a
T10915 15203-15207 NN denotes role
T10916 15208-15210 IN denotes in
T10917 15211-15217 NN denotes neuron
T10918 15218-15224 NN denotes neuron
T10919 15217-15218 SYM denotes -
T10920 15246-15258 NNS denotes interactions
T10921 15225-15227 CC denotes or
T10922 15228-15234 NN denotes neuron
T10923 15241-15245 NN denotes cell
T10924 15234-15235 SYM denotes -
T10925 15235-15240 JJ denotes glial
T10926 15258-15260 , denotes ,
T10927 15260-15261 DT denotes a
T10928 15289-15302 NN denotes investigation
T10929 15262-15266 RBR denotes more
T10930 15267-15274 JJ denotes precise
T10931 15275-15288 JJ denotes morphological
T10932 15303-15307 MD denotes will
T10933 15308-15310 VB denotes be
T10934 15317-15318 . denotes .
T10935 15318-15594 sentence denotes It has been reported that adhesion molecules, such as neural cell adhesion molecule (NCAM), are not only implicated in cell interactions during nervous system development, but are also recognised as important mediators of synaptic plasticity in the adult nervous system [35].
T10936 15319-15321 PRP denotes It
T10937 15331-15339 VBN denotes reported
T10938 15322-15325 VBZ denotes has
T10939 15326-15330 VBN denotes been
T10940 15340-15344 IN denotes that
T10941 15424-15434 VBN denotes implicated
T10942 15345-15353 NN denotes adhesion
T10943 15354-15363 NNS denotes molecules
T10944 15363-15365 , denotes ,
T10945 15365-15369 JJ denotes such
T10946 15370-15372 IN denotes as
T10947 15373-15379 JJ denotes neural
T10948 15380-15384 NN denotes cell
T10949 15394-15402 NN denotes molecule
T10950 15385-15393 NN denotes adhesion
T10951 15403-15404 -LRB- denotes (
T10952 15404-15408 NN denotes NCAM
T10953 15408-15409 -RRB- denotes )
T10954 15409-15411 , denotes ,
T10955 15411-15414 VBP denotes are
T10956 15415-15418 RB denotes not
T10957 15419-15423 RB denotes only
T10958 15435-15437 IN denotes in
T10959 15438-15442 NN denotes cell
T10960 15443-15455 NNS denotes interactions
T10961 15456-15462 IN denotes during
T10962 15463-15470 JJ denotes nervous
T10963 15471-15477 NN denotes system
T10964 15478-15489 NN denotes development
T10965 15489-15491 , denotes ,
T10966 15491-15494 CC denotes but
T10967 15495-15498 VBP denotes are
T10968 15504-15514 VBN denotes recognised
T10969 15499-15503 RB denotes also
T10970 15515-15517 IN denotes as
T10971 15518-15527 JJ denotes important
T10972 15528-15537 NNS denotes mediators
T10973 15538-15540 IN denotes of
T10974 15541-15549 JJ denotes synaptic
T10975 15550-15560 NN denotes plasticity
T10976 15561-15563 IN denotes in
T10977 15564-15567 DT denotes the
T10978 15582-15588 NN denotes system
T10979 15568-15573 JJ denotes adult
T10980 15574-15581 JJ denotes nervous
T10981 15589-15590 -LRB- denotes [
T10982 15590-15592 CD denotes 35
T10983 15592-15593 -RRB- denotes ]
T10984 15593-15594 . denotes .
T10985 15594-15867 sentence denotes Changes in neuron excitability in the hippocampus, such as decreases in the post-burst after hyperpolarization (AHP), have been thought to affect long-term potentiation (LTP) [36], an experimental model of the synaptic changes thought to underlie learning and memory [37].
T10986 15595-15602 NNS denotes Changes
T10987 15723-15730 VBN denotes thought
T10988 15603-15605 IN denotes in
T10989 15606-15612 NN denotes neuron
T10990 15613-15625 NN denotes excitability
T10991 15626-15628 IN denotes in
T10992 15629-15632 DT denotes the
T10993 15633-15644 NN denotes hippocampus
T10994 15644-15646 , denotes ,
T10995 15646-15650 JJ denotes such
T10996 15651-15653 IN denotes as
T10997 15654-15663 NNS denotes decreases
T10998 15664-15666 IN denotes in
T10999 15667-15670 DT denotes the
T11000 15671-15681 JJ denotes post-burst
T11001 15682-15687 IN denotes after
T11002 15688-15705 NN denotes hyperpolarization
T11003 15706-15707 -LRB- denotes (
T11004 15707-15710 NN denotes AHP
T11005 15710-15711 -RRB- denotes )
T11006 15711-15713 , denotes ,
T11007 15713-15717 VBP denotes have
T11008 15718-15722 VBN denotes been
T11009 15731-15733 TO denotes to
T11010 15734-15740 VB denotes affect
T11011 15741-15745 JJ denotes long
T11012 15746-15750 NN denotes term
T11013 15745-15746 HYPH denotes -
T11014 15751-15763 NN denotes potentiation
T11015 15764-15765 -LRB- denotes (
T11016 15765-15768 NN denotes LTP
T11017 15768-15769 -RRB- denotes )
T11018 15770-15771 -LRB- denotes [
T11019 15771-15773 CD denotes 36
T11020 15773-15774 -RRB- denotes ]
T11021 15774-15776 , denotes ,
T11022 15776-15778 DT denotes an
T11023 15792-15797 NN denotes model
T11024 15779-15791 JJ denotes experimental
T11025 15798-15800 IN denotes of
T11026 15801-15804 DT denotes the
T11027 15814-15821 NNS denotes changes
T11028 15805-15813 JJ denotes synaptic
T11029 15822-15829 VBN denotes thought
T11030 15830-15832 TO denotes to
T11031 15833-15841 VB denotes underlie
T11032 15842-15850 NN denotes learning
T11033 15851-15854 CC denotes and
T11034 15855-15861 NN denotes memory
T11035 15862-15863 -LRB- denotes [
T11036 15863-15865 CD denotes 37
T11037 15865-15866 -RRB- denotes ]
T11038 15866-15867 . denotes .
T11039 15867-16106 sentence denotes It has also been reported that mice lacking NMDA receptor for both NR2A and NR2C subunits showed motor dysfunction and complete loss of both spontaneous and evoked excitatory postsynaptic currents (EPSCs) in cerebellar granule cells [38].
T11040 15868-15870 PRP denotes It
T11041 15885-15893 VBN denotes reported
T11042 15871-15874 VBZ denotes has
T11043 15875-15879 RB denotes also
T11044 15880-15884 VBN denotes been
T11045 15894-15898 IN denotes that
T11046 15958-15964 VBD denotes showed
T11047 15899-15903 NNS denotes mice
T11048 15904-15911 VBG denotes lacking
T11049 15912-15916 NN denotes NMDA
T11050 15917-15925 NN denotes receptor
T11051 15926-15929 IN denotes for
T11052 15930-15934 CC denotes both
T11053 15949-15957 NNS denotes subunits
T11054 15935-15939 NN denotes NR2A
T11055 15940-15943 CC denotes and
T11056 15944-15948 NN denotes NR2C
T11057 15965-15970 NN denotes motor
T11058 15971-15982 NN denotes dysfunction
T11059 15983-15986 CC denotes and
T11060 15987-15995 JJ denotes complete
T11061 15996-16000 NN denotes loss
T11062 16001-16003 IN denotes of
T11063 16004-16008 CC denotes both
T11064 16009-16020 JJ denotes spontaneous
T11065 16056-16064 NNS denotes currents
T11066 16021-16024 CC denotes and
T11067 16025-16031 VBN denotes evoked
T11068 16032-16042 JJ denotes excitatory
T11069 16043-16055 JJ denotes postsynaptic
T11070 16065-16066 -LRB- denotes (
T11071 16066-16071 NNS denotes EPSCs
T11072 16071-16072 -RRB- denotes )
T11073 16073-16075 IN denotes in
T11074 16076-16086 JJ denotes cerebellar
T11075 16095-16100 NNS denotes cells
T11076 16087-16094 NN denotes granule
T11077 16101-16102 -LRB- denotes [
T11078 16102-16104 CD denotes 38
T11079 16104-16105 -RRB- denotes ]
T11080 16105-16106 . denotes .
T11081 16106-16278 sentence denotes Therefore, electrophyological studies to enable analysis of synaptic transmission and plasticity in the hippocampus and cerebellum of ADAM11-deficient mice will be needed.
T11082 16107-16116 RB denotes Therefore
T11083 16271-16277 VBN denotes needed
T11084 16116-16118 , denotes ,
T11085 16118-16136 JJ denotes electrophyological
T11086 16137-16144 NNS denotes studies
T11087 16145-16147 TO denotes to
T11088 16148-16154 VB denotes enable
T11089 16155-16163 NN denotes analysis
T11090 16164-16166 IN denotes of
T11091 16167-16175 JJ denotes synaptic
T11092 16176-16188 NN denotes transmission
T11093 16189-16192 CC denotes and
T11094 16193-16203 NN denotes plasticity
T11095 16204-16206 IN denotes in
T11096 16207-16210 DT denotes the
T11097 16211-16222 NN denotes hippocampus
T11098 16223-16226 CC denotes and
T11099 16227-16237 NN denotes cerebellum
T11100 16238-16240 IN denotes of
T11101 16241-16247 NN denotes ADAM11
T11102 16248-16257 JJ denotes deficient
T11103 16247-16248 HYPH denotes -
T11104 16258-16262 NNS denotes mice
T11105 16263-16267 MD denotes will
T11106 16268-16270 VB denotes be
T11107 16277-16278 . denotes .
T11108 16278-16444 sentence denotes These studies might clarify whether ADAM11 plays an important signalling or structural role at the synaptic level and whether it participates in synaptic regulation.
T11109 16279-16284 DT denotes These
T11110 16285-16292 NNS denotes studies
T11111 16299-16306 VB denotes clarify
T11112 16293-16298 MD denotes might
T11113 16307-16314 IN denotes whether
T11114 16322-16327 VBZ denotes plays
T11115 16315-16321 NN denotes ADAM11
T11116 16328-16330 DT denotes an
T11117 16366-16370 NN denotes role
T11118 16331-16340 JJ denotes important
T11119 16341-16351 NN denotes signalling
T11120 16352-16354 CC denotes or
T11121 16355-16365 JJ denotes structural
T11122 16371-16373 IN denotes at
T11123 16374-16377 DT denotes the
T11124 16387-16392 NN denotes level
T11125 16378-16386 JJ denotes synaptic
T11126 16393-16396 CC denotes and
T11127 16397-16404 IN denotes whether
T11128 16408-16420 VBZ denotes participates
T11129 16405-16407 PRP denotes it
T11130 16421-16423 IN denotes in
T11131 16424-16432 JJ denotes synaptic
T11132 16433-16443 NN denotes regulation
T11133 16443-16444 . denotes .
T11134 16444-16594 sentence denotes ADAM11-deficient mice remained alive for more than one year without ataxia or tremor, but showed a deficit in spatial learning and motor dysfunction.
T11135 16445-16451 NN denotes ADAM11
T11136 16452-16461 JJ denotes deficient
T11137 16451-16452 HYPH denotes -
T11138 16462-16466 NNS denotes mice
T11139 16467-16475 VBD denotes remained
T11140 16476-16481 JJ denotes alive
T11141 16482-16485 IN denotes for
T11142 16486-16490 JJR denotes more
T11143 16496-16499 CD denotes one
T11144 16491-16495 IN denotes than
T11145 16500-16504 NN denotes year
T11146 16505-16512 IN denotes without
T11147 16513-16519 NN denotes ataxia
T11148 16520-16522 CC denotes or
T11149 16523-16529 NN denotes tremor
T11150 16529-16531 , denotes ,
T11151 16531-16534 CC denotes but
T11152 16535-16541 VBD denotes showed
T11153 16542-16543 DT denotes a
T11154 16544-16551 NN denotes deficit
T11155 16552-16554 IN denotes in
T11156 16555-16562 JJ denotes spatial
T11157 16563-16571 NN denotes learning
T11158 16572-16575 CC denotes and
T11159 16576-16581 NN denotes motor
T11160 16582-16593 NN denotes dysfunction
T11161 16593-16594 . denotes .
T11162 16594-16753 sentence denotes On the other hand, mice lacking the Adam22 gene showed severe ataxia, exhibited marked hypomyelination of the peripheral nerves, and died before weaning [22].
T11163 16595-16597 IN denotes On
T11164 16643-16649 VBD denotes showed
T11165 16598-16601 DT denotes the
T11166 16608-16612 NN denotes hand
T11167 16602-16607 JJ denotes other
T11168 16612-16614 , denotes ,
T11169 16614-16618 NNS denotes mice
T11170 16619-16626 VBG denotes lacking
T11171 16627-16630 DT denotes the
T11172 16638-16642 NN denotes gene
T11173 16631-16637 NN denotes Adam22
T11174 16650-16656 JJ denotes severe
T11175 16657-16663 NN denotes ataxia
T11176 16663-16665 , denotes ,
T11177 16665-16674 VBD denotes exhibited
T11178 16675-16681 JJ denotes marked
T11179 16682-16697 NN denotes hypomyelination
T11180 16698-16700 IN denotes of
T11181 16701-16704 DT denotes the
T11182 16716-16722 NNS denotes nerves
T11183 16705-16715 JJ denotes peripheral
T11184 16722-16724 , denotes ,
T11185 16724-16727 CC denotes and
T11186 16728-16732 VBD denotes died
T11187 16733-16739 IN denotes before
T11188 16740-16747 NN denotes weaning
T11189 16748-16749 -LRB- denotes [
T11190 16749-16751 CD denotes 22
T11191 16751-16752 -RRB- denotes ]
T11192 16752-16753 . denotes .
T11193 16753-16844 sentence denotes Mice lacking the Adam23 gene showed severe ataxia and tremor and died before weaning [23].
T11194 16754-16758 NNS denotes Mice
T11195 16783-16789 VBD denotes showed
T11196 16759-16766 VBG denotes lacking
T11197 16767-16770 DT denotes the
T11198 16778-16782 NN denotes gene
T11199 16771-16777 NN denotes Adam23
T11200 16790-16796 JJ denotes severe
T11201 16797-16803 NN denotes ataxia
T11202 16804-16807 CC denotes and
T11203 16808-16814 NN denotes tremor
T11204 16815-16818 CC denotes and
T11205 16819-16823 VBD denotes died
T11206 16824-16830 IN denotes before
T11207 16831-16838 NN denotes weaning
T11208 16839-16840 -LRB- denotes [
T11209 16840-16842 CD denotes 23
T11210 16842-16843 -RRB- denotes ]
T11211 16843-16844 . denotes .
T11212 16844-16955 sentence denotes These findings suggest that ADAM11, ADAM22 and ADAM23 have separate and important roles in the nervous system.
T11213 16845-16850 DT denotes These
T11214 16851-16859 NNS denotes findings
T11215 16860-16867 VBP denotes suggest
T11216 16868-16872 IN denotes that
T11217 16899-16903 VBP denotes have
T11218 16873-16879 NN denotes ADAM11
T11219 16879-16881 , denotes ,
T11220 16881-16887 NN denotes ADAM22
T11221 16888-16891 CC denotes and
T11222 16892-16898 NN denotes ADAM23
T11223 16904-16912 JJ denotes separate
T11224 16927-16932 NNS denotes roles
T11225 16913-16916 CC denotes and
T11226 16917-16926 JJ denotes important
T11227 16933-16935 IN denotes in
T11228 16936-16939 DT denotes the
T11229 16948-16954 NN denotes system
T11230 16940-16947 JJ denotes nervous
T11231 16954-16955 . denotes .
T11232 16955-17123 sentence denotes A genome database search revealed orthologs of ADAM11, ADAM22 and ADAM23 genes to exist in vertebrates such as mammals, fish, and amphibians, but not in invertebrates.
T11233 16956-16957 DT denotes A
T11234 16974-16980 NN denotes search
T11235 16958-16964 NN denotes genome
T11236 16965-16973 NN denotes database
T11237 16981-16989 VBD denotes revealed
T11238 16990-16999 NNS denotes orthologs
T11239 17038-17043 VB denotes exist
T11240 17000-17002 IN denotes of
T11241 17003-17009 NN denotes ADAM11
T11242 17029-17034 NNS denotes genes
T11243 17009-17011 , denotes ,
T11244 17011-17017 NN denotes ADAM22
T11245 17018-17021 CC denotes and
T11246 17022-17028 NN denotes ADAM23
T11247 17035-17037 TO denotes to
T11248 17044-17046 IN denotes in
T11249 17047-17058 NNS denotes vertebrates
T11250 17059-17063 JJ denotes such
T11251 17064-17066 IN denotes as
T11252 17067-17074 NNS denotes mammals
T11253 17074-17076 , denotes ,
T11254 17076-17080 NNS denotes fish
T11255 17080-17082 , denotes ,
T11256 17082-17085 CC denotes and
T11257 17086-17096 NNS denotes amphibians
T11258 17096-17098 , denotes ,
T11259 17098-17101 CC denotes but
T11260 17102-17105 RB denotes not
T11261 17106-17108 IN denotes in
T11262 17109-17122 NNS denotes invertebrates
T11263 17122-17123 . denotes .
T11264 17123-17297 sentence denotes Although the precise molecular functions of these ADAMs are still unclear, further investigations will provide clues to understanding the nervous system of higher organisms.
T11265 17124-17132 IN denotes Although
T11266 17180-17183 VBP denotes are
T11267 17133-17136 DT denotes the
T11268 17155-17164 NNS denotes functions
T11269 17137-17144 JJ denotes precise
T11270 17145-17154 JJ denotes molecular
T11498 17310-17316 NN denotes ADAM11
T11499 17317-17326 JJ denotes deficient
T11500 17316-17317 HYPH denotes -
T11501 17327-17331 NNS denotes mice
T11502 17332-17340 VBD denotes survived
T11503 17341-17345 JJR denotes more
T11504 17351-17354 CD denotes one
T11505 17346-17350 IN denotes than
T11506 17355-17359 NN denotes year
T11507 17360-17367 IN denotes without
T11508 17368-17374 NN denotes ataxia
T11509 17375-17377 CC denotes or
T11510 17378-17384 NN denotes tremor
T11511 17384-17386 , denotes ,
T11512 17386-17392 VBD denotes showed
T11513 17393-17395 DT denotes no
T11514 17396-17409 NNS denotes abnormalities
T11515 17410-17412 IN denotes in
T11516 17413-17417 NN denotes body
T11517 17418-17424 NN denotes weight
T11518 17425-17429 NN denotes gain
T11519 17429-17431 , denotes ,
T11520 17431-17442 JJ denotes spontaneous
T11521 17449-17457 NN denotes activity
T11522 17443-17448 NN denotes motor
T11523 17457-17459 , denotes ,
T11524 17459-17465 NN denotes muscle
T11525 17466-17474 NN denotes strength
T11526 17474-17476 , denotes ,
T11527 17476-17478 CC denotes or
T11528 17479-17486 NN denotes walking
T11529 17487-17495 NNS denotes patterns
T11530 17495-17497 , denotes ,
T11531 17497-17500 CC denotes and
T11532 17501-17510 VBD denotes exhibited
T11533 17511-17513 DT denotes no
T11534 17547-17554 NNS denotes changes
T11535 17514-17522 JJ denotes apparent
T11536 17523-17533 JJ denotes anatomical
T11537 17534-17546 JJ denotes histological
T11538 17533-17534 HYPH denotes -
T11539 17554-17555 . denotes .
T11540 17555-17739 sentence denotes However, hippocampus-dependent spatial learning and cerebellum-dependent motor coordination in ADAM11-deficient mice were impaired when tested using water maze and rotating rod tasks.
T11541 17556-17563 RB denotes However
T11542 17678-17686 VBN denotes impaired
T11543 17563-17565 , denotes ,
T11544 17565-17576 NN denotes hippocampus
T11545 17577-17586 JJ denotes dependent
T11546 17576-17577 HYPH denotes -
T11547 17595-17603 NN denotes learning
T11548 17587-17594 JJ denotes spatial
T11549 17604-17607 CC denotes and
T11550 17608-17618 NN denotes cerebellum
T11551 17619-17628 JJ denotes dependent
T11552 17618-17619 HYPH denotes -
T11553 17635-17647 NN denotes coordination
T11554 17629-17634 NN denotes motor
T11555 17648-17650 IN denotes in
T11556 17651-17657 NN denotes ADAM11
T11557 17658-17667 JJ denotes deficient
T11558 17657-17658 HYPH denotes -
T11559 17668-17672 NNS denotes mice
T11560 17673-17677 VBD denotes were
T11561 17687-17691 WRB denotes when
T11562 17692-17698 VBN denotes tested
T11563 17699-17704 VBG denotes using
T11564 17705-17710 NN denotes water
T11565 17711-17715 NN denotes maze
T11566 17733-17738 NNS denotes tasks
T11567 17716-17719 CC denotes and
T11568 17720-17728 VBG denotes rotating
T11569 17729-17732 NN denotes rod
T11570 17738-17739 . denotes .
T11571 17739-17908 sentence denotes Our genetically modified mouse strain has the potential to be a useful and sensitive tools for detailed investigation of ADAM proteins' functions in the nervous system.
T11572 17740-17743 PRP$ denotes Our
T11573 17771-17777 NN denotes strain
T11574 17744-17755 RB denotes genetically
T11575 17756-17764 VBN denotes modified
T11576 17765-17770 NN denotes mouse
T11577 17778-17781 VBZ denotes has
T11578 17782-17785 DT denotes the
T11579 17786-17795 NN denotes potential
T11580 17796-17798 TO denotes to
T11581 17799-17801 VB denotes be
T11582 17802-17803 DT denotes a
T11583 17825-17830 NNS denotes tools
T11584 17804-17810 JJ denotes useful
T11585 17811-17814 CC denotes and
T11586 17815-17824 JJ denotes sensitive
T11587 17831-17834 IN denotes for
T11588 17835-17843 JJ denotes detailed
T11589 17844-17857 NN denotes investigation
T11590 17858-17860 IN denotes of
T11591 17861-17865 NN denotes ADAM
T11592 17866-17874 NN denotes proteins
T11593 17876-17885 NNS denotes functions
T11594 17874-17875 POS denotes '
T11595 17886-17888 IN denotes in
T11596 17889-17892 DT denotes the
T11597 17901-17907 NN denotes system
T11598 17893-17900 JJ denotes nervous
T11599 17907-17908 . denotes .
T11864 17919-17931 NN denotes Construction
T11865 17932-17934 IN denotes of
T11866 17935-17937 DT denotes an
T11867 17960-17966 NN denotes vector
T11868 17938-17944 NN denotes Adam11
T11869 17945-17949 NN denotes gene
T11870 17949-17950 HYPH denotes -
T11871 17950-17959 VBG denotes targeting
T11872 17966-18166 sentence denotes The 13.7-kb BamHI DNA fragment covering exons 2 – 20 of the Adam11 gene was amplified from C57BL/6 genomic DNA by the PCR using Expand Hi-Fidelity polymerase mix (Roche Diagnostics KK, Tokyo, Japan).
T11873 17967-17970 DT denotes The
T11874 17989-17997 NN denotes fragment
T11875 17971-17975 CD denotes 13.7
T11876 17976-17978 NN denotes kb
T11877 17975-17976 HYPH denotes -
T11878 17979-17984 NN denotes BamHI
T11879 17985-17988 NN denotes DNA
T11880 18043-18052 VBN denotes amplified
T11881 17998-18006 VBG denotes covering
T11882 18007-18012 NNS denotes exons
T11883 18013-18014 CD denotes 2
T11884 18015-18016 SYM denotes –
T11885 18017-18019 CD denotes 20
T11886 18020-18022 IN denotes of
T11887 18023-18026 DT denotes the
T11888 18034-18038 NN denotes gene
T11889 18027-18033 NN denotes Adam11
T11890 18039-18042 VBD denotes was
T11891 18053-18057 IN denotes from
T11892 18058-18063 NN denotes C57BL
T11893 18074-18077 NN denotes DNA
T11894 18063-18064 HYPH denotes /
T11895 18064-18065 CD denotes 6
T11896 18066-18073 JJ denotes genomic
T11897 18078-18080 IN denotes by
T11898 18081-18084 DT denotes the
T11899 18085-18088 NN denotes PCR
T11900 18089-18094 VBG denotes using
T11901 18095-18101 NN denotes Expand
T11902 18125-18128 NN denotes mix
T11903 18102-18104 NNP denotes Hi
T11904 18105-18113 NNP denotes Fidelity
T11905 18104-18105 HYPH denotes -
T11906 18114-18124 NN denotes polymerase
T11907 18129-18130 -LRB- denotes (
T11908 18148-18150 NNP denotes KK
T11909 18130-18135 NNP denotes Roche
T11910 18136-18147 NNP denotes Diagnostics
T11911 18150-18152 , denotes ,
T11912 18152-18157 NNP denotes Tokyo
T11913 18157-18159 , denotes ,
T11914 18159-18164 NNP denotes Japan
T11915 18164-18165 -RRB- denotes )
T11916 18165-18166 . denotes .
T11917 18166-18282 sentence denotes To generate a mutation in the mouse Adam11 gene, we inserted a PGKneo cassette into exons 5 – 7 of the Adam11 gene.
T11918 18167-18169 TO denotes To
T11919 18170-18178 VB denotes generate
T11920 18219-18227 VBD denotes inserted
T11921 18179-18180 DT denotes a
T11922 18181-18189 NN denotes mutation
T11923 18190-18192 IN denotes in
T11924 18193-18196 DT denotes the
T11925 18210-18214 NN denotes gene
T11926 18197-18202 NN denotes mouse
T11927 18203-18209 NN denotes Adam11
T11928 18214-18216 , denotes ,
T11929 18216-18218 PRP denotes we
T11930 18228-18229 DT denotes a
T11931 18237-18245 NN denotes cassette
T11932 18230-18236 NN denotes PGKneo
T11933 18246-18250 IN denotes into
T11934 18251-18256 NNS denotes exons
T11935 18257-18258 CD denotes 5
T11936 18259-18260 SYM denotes –
T11937 18261-18262 CD denotes 7
T11938 18263-18265 IN denotes of
T11939 18266-18269 DT denotes the
T11940 18277-18281 NN denotes gene
T11941 18270-18276 NN denotes Adam11
T11942 18281-18282 . denotes .
T11943 18282-18513 sentence denotes The final targeting construct consisted of a 10.1-kb genomic DNA fragment that was interrupted by the insertion of the PGKneo cassette and contained a MC1/TK cassette as a negative selection marker against random integration [39].
T11944 18283-18286 DT denotes The
T11945 18303-18312 NN denotes construct
T11946 18287-18292 JJ denotes final
T11947 18293-18302 NN denotes targeting
T11948 18313-18322 VBD denotes consisted
T11949 18323-18325 IN denotes of
T11950 18326-18327 DT denotes a
T11951 18348-18356 NN denotes fragment
T11952 18328-18332 CD denotes 10.1
T11953 18333-18335 NN denotes kb
T11954 18332-18333 HYPH denotes -
T11955 18336-18343 JJ denotes genomic
T11956 18344-18347 NN denotes DNA
T11957 18357-18361 WDT denotes that
T11958 18366-18377 VBN denotes interrupted
T11959 18362-18365 VBD denotes was
T11960 18378-18380 IN denotes by
T11961 18381-18384 DT denotes the
T11962 18385-18394 NN denotes insertion
T11963 18395-18397 IN denotes of
T11964 18398-18401 DT denotes the
T11965 18409-18417 NN denotes cassette
T11966 18402-18408 NN denotes PGKneo
T11967 18418-18421 CC denotes and
T11968 18422-18431 VBD denotes contained
T11969 18432-18433 DT denotes a
T11970 18441-18449 NN denotes cassette
T11971 18434-18437 NN denotes MC1
T11972 18438-18440 NN denotes TK
T11973 18437-18438 HYPH denotes /
T11974 18450-18452 IN denotes as
T11975 18453-18454 DT denotes a
T11976 18474-18480 NN denotes marker
T11977 18455-18463 JJ denotes negative
T11978 18464-18473 NN denotes selection
T11979 18481-18488 IN denotes against
T11980 18489-18495 JJ denotes random
T11981 18496-18507 NN denotes integration
T11982 18508-18509 -LRB- denotes [
T11983 18509-18511 CD denotes 39
T11984 18511-18512 -RRB- denotes ]
T11985 18512-18513 . denotes .
T12309 18515-18525 NN denotes Generation
T12310 18526-18528 IN denotes of
T12311 18529-18535 NN denotes Adam11
T12312 18536-18545 JJ denotes deficient
T12313 18546-18550 NNS denotes mice
T12314 18550-18642 sentence denotes The linearised targeting vector was electroporated into TT2 embryonic stem (ES) cells [40].
T12315 18551-18554 DT denotes The
T12316 18576-18582 NN denotes vector
T12317 18555-18565 VBN denotes linearised
T12318 18566-18575 NN denotes targeting
T12319 18587-18601 VBN denotes electroporated
T12320 18583-18586 VBD denotes was
T12321 18602-18606 IN denotes into
T12322 18607-18610 NN denotes TT2
T12323 18631-18636 NNS denotes cells
T12324 18611-18620 JJ denotes embryonic
T12325 18621-18625 NN denotes stem
T12326 18626-18627 -LRB- denotes (
T12327 18627-18629 NN denotes ES
T12328 18629-18630 -RRB- denotes )
T12329 18637-18638 -LRB- denotes [
T12330 18638-18640 CD denotes 40
T12331 18640-18641 -RRB- denotes ]
T12332 18641-18642 . denotes .
T12333 18642-18856 sentence denotes Homologous recombinants were selected by PCR using the following primers, AGN1: 5'-TCGTGCTTTACGGTATCGCCGCTCCCGATT-3' in the PGKneo cassette, and SGN033: 5'-GGACCCGGAAGACATTTGCACGGT-3' outside the targeting vector.
T12334 18643-18653 JJ denotes Homologous
T12335 18654-18666 NNS denotes recombinants
T12336 18672-18680 VBN denotes selected
T12337 18667-18671 VBD denotes were
T12338 18681-18683 IN denotes by
T12339 18684-18687 NN denotes PCR
T12340 18688-18693 VBG denotes using
T12341 18694-18697 DT denotes the
T12342 18708-18715 NNS denotes primers
T12343 18698-18707 VBG denotes following
T12344 18715-18717 , denotes ,
T12345 18717-18721 NN denotes AGN1
T12346 18721-18723 : denotes :
T12347 18723-18724 CD denotes 5
T12348 18724-18725 SYM denotes '
T12349 18725-18726 HYPH denotes -
T12350 18726-18756 NN denotes TCGTGCTTTACGGTATCGCCGCTCCCGATT
T12351 18756-18757 HYPH denotes -
T12352 18757-18758 CD denotes 3
T12353 18758-18759 SYM denotes '
T12354 18760-18762 IN denotes in
T12355 18763-18766 DT denotes the
T12356 18774-18782 NN denotes cassette
T12357 18767-18773 NN denotes PGKneo
T12358 18782-18784 , denotes ,
T12359 18784-18787 CC denotes and
T12360 18788-18794 NN denotes SGN033
T12361 18794-18796 : denotes :
T12362 18796-18797 CD denotes 5
T12363 18797-18798 SYM denotes '
T12364 18798-18799 HYPH denotes -
T12365 18799-18823 NN denotes GGACCCGGAAGACATTTGCACGGT
T12366 18823-18824 HYPH denotes -
T12367 18824-18825 CD denotes 3
T12368 18825-18826 SYM denotes '
T12369 18827-18834 IN denotes outside
T12370 18835-18838 DT denotes the
T12371 18849-18855 NN denotes vector
T12372 18839-18848 NN denotes targeting
T12373 18855-18856 . denotes .
T12374 18856-18988 sentence denotes Homologous recombined DNA was efficiently amplified by 35 cycles of the following amplification steps (94°C-30 sec and 68°C-5 min).
T12375 18857-18867 JJ denotes Homologous
T12376 18879-18882 NN denotes DNA
T12377 18868-18878 VBN denotes recombined
T12378 18899-18908 VBN denotes amplified
T12379 18883-18886 VBD denotes was
T12380 18887-18898 RB denotes efficiently
T12381 18909-18911 IN denotes by
T12382 18912-18914 CD denotes 35
T12383 18915-18921 NNS denotes cycles
T12384 18922-18924 IN denotes of
T12385 18925-18928 DT denotes the
T12386 18953-18958 NNS denotes steps
T12387 18929-18938 VBG denotes following
T12388 18939-18952 NN denotes amplification
T12389 18959-18960 -LRB- denotes (
T12390 18960-18962 CD denotes 94
T12391 18962-18964 NN denotes °C
T12392 18964-18965 SYM denotes -
T12393 18965-18967 CD denotes 30
T12394 18968-18971 NN denotes sec
T12395 18972-18975 CC denotes and
T12396 18976-18978 CD denotes 68
T12397 18978-18980 NN denotes °C
T12398 18980-18981 SYM denotes -
T12399 18981-18982 CD denotes 5
T12400 18983-18986 NN denotes min
T12401 18986-18987 -RRB- denotes )
T12402 18987-18988 . denotes .
T12403 18988-19087 sentence denotes Correctly targeted ES clones were injected into fertilised ICR mouse eggs at the eight-cell stage.
T12404 18989-18998 RB denotes Correctly
T12405 18999-19007 VBN denotes targeted
T12406 19011-19017 NNS denotes clones
T12407 19008-19010 NN denotes ES
T12408 19023-19031 VBN denotes injected
T12409 19018-19022 VBD denotes were
T12410 19032-19036 IN denotes into
T12411 19037-19047 VBN denotes fertilised
T12412 19058-19062 NNS denotes eggs
T12413 19048-19051 NN denotes ICR
T12414 19052-19057 NN denotes mouse
T12415 19063-19065 IN denotes at
T12416 19066-19069 DT denotes the
T12417 19081-19086 NN denotes stage
T12418 19070-19075 CD denotes eight
T12419 19076-19080 NN denotes cell
T12420 19075-19076 HYPH denotes -
T12421 19086-19087 . denotes .
T12422 19087-19292 sentence denotes The resulting male chimeras were mated with C57BL/6NCrj females (Charles River Japan, Tokyo, Japan), and resulting heterozygous (+/-) male and female mice were interbred to generate homozygous (-/-) mice.
T12423 19088-19091 DT denotes The
T12424 19107-19115 NNS denotes chimeras
T12425 19092-19101 VBG denotes resulting
T12426 19102-19106 JJ denotes male
T12427 19121-19126 VBN denotes mated
T12428 19116-19120 VBD denotes were
T12429 19127-19131 IN denotes with
T12430 19132-19137 NN denotes C57BL
T12431 19138-19143 NN denotes 6NCrj
T12432 19137-19138 HYPH denotes /
T12433 19144-19151 NNS denotes females
T12434 19152-19153 -LRB- denotes (
T12435 19167-19172 NNP denotes Japan
T12436 19153-19160 NNP denotes Charles
T12437 19161-19166 NNP denotes River
T12438 19172-19174 , denotes ,
T12439 19174-19179 NNP denotes Tokyo
T12440 19179-19181 , denotes ,
T12441 19181-19186 NNP denotes Japan
T12442 19186-19187 -RRB- denotes )
T12443 19187-19189 , denotes ,
T12444 19189-19192 CC denotes and
T12445 19193-19202 VBG denotes resulting
T12446 19238-19242 NNS denotes mice
T12447 19203-19215 JJ denotes heterozygous
T12448 19216-19217 -LRB- denotes (
T12449 19217-19218 SYM denotes +
T12450 19219-19220 SYM denotes -
T12451 19218-19219 HYPH denotes /
T12452 19220-19221 -RRB- denotes )
T12453 19222-19226 JJ denotes male
T12454 19227-19230 CC denotes and
T12455 19231-19237 JJ denotes female
T12456 19248-19257 VBN denotes interbred
T12457 19243-19247 VBD denotes were
T12458 19258-19260 TO denotes to
T12459 19261-19269 VB denotes generate
T12460 19270-19280 JJ denotes homozygous
T12461 19287-19291 NNS denotes mice
T12462 19281-19282 -LRB- denotes (
T12463 19282-19283 SYM denotes -
T12464 19284-19285 SYM denotes -
T12465 19283-19284 HYPH denotes /
T12466 19285-19286 -RRB- denotes )
T12467 19291-19292 . denotes .
T12589 19303-19307 NN denotes blot
T12590 19308-19316 NN denotes analysis
T12591 19316-19413 sentence denotes Mouse genomic DNA used for Southern blot analysis was extracted from the liver of each genotype.
T12592 19317-19322 NN denotes Mouse
T12593 19331-19334 NN denotes DNA
T12594 19323-19330 JJ denotes genomic
T12595 19371-19380 VBN denotes extracted
T12596 19335-19339 VBN denotes used
T12597 19340-19343 IN denotes for
T12598 19344-19352 NNP denotes Southern
T12599 19353-19357 NN denotes blot
T12600 19358-19366 NN denotes analysis
T12601 19367-19370 VBD denotes was
T12602 19381-19385 IN denotes from
T12603 19386-19389 DT denotes the
T12604 19390-19395 NN denotes liver
T12605 19396-19398 IN denotes of
T12606 19399-19403 DT denotes each
T12607 19404-19412 NN denotes genotype
T12608 19412-19413 . denotes .
T12609 19413-19558 sentence denotes BamHI-digested genomic DNA was probed with the [32P]-labelled BE2K probe, which was a 2.0-kb BamHI – EcoRI genomic fragment located in intron 2.
T12610 19414-19419 NN denotes BamHI
T12611 19420-19428 VBN denotes digested
T12612 19419-19420 HYPH denotes -
T12613 19437-19440 NN denotes DNA
T12614 19429-19436 JJ denotes genomic
T12615 19445-19451 VBN denotes probed
T12616 19441-19444 VBD denotes was
T12617 19452-19456 IN denotes with
T12618 19457-19460 DT denotes the
T12619 19481-19486 NN denotes probe
T12620 19461-19462 -LRB- denotes [
T12621 19462-19465 NN denotes 32P
T12622 19467-19475 VBN denotes labelled
T12623 19465-19466 -RRB- denotes ]
T12624 19466-19467 HYPH denotes -
T12625 19476-19480 NN denotes BE2K
T12626 19486-19488 , denotes ,
T12627 19488-19493 WDT denotes which
T12628 19494-19497 VBD denotes was
T12629 19498-19499 DT denotes a
T12630 19529-19537 NN denotes fragment
T12631 19500-19503 CD denotes 2.0
T12632 19504-19506 NN denotes kb
T12633 19503-19504 HYPH denotes -
T12634 19507-19512 NN denotes BamHI
T12635 19515-19520 NN denotes EcoRI
T12636 19513-19514 HYPH denotes –
T12637 19521-19528 JJ denotes genomic
T12638 19538-19545 VBN denotes located
T12639 19546-19548 IN denotes in
T12640 19549-19555 NN denotes intron
T12641 19556-19557 CD denotes 2
T12642 19557-19558 . denotes .
T13011 19560-19567 NNP denotes Western
T13012 19568-19572 NN denotes blot
T13013 19573-19581 NN denotes analysis
T13014 19581-19669 sentence denotes The absence of ADAM11 protein in the (-/-) mice was confirmed by Western blot analysis.
T13015 19582-19585 DT denotes The
T13016 19586-19593 NN denotes absence
T13017 19634-19643 VBN denotes confirmed
T13018 19594-19596 IN denotes of
T13019 19597-19603 NN denotes ADAM11
T13020 19604-19611 NN denotes protein
T13021 19612-19614 IN denotes in
T13022 19615-19618 DT denotes the
T13023 19625-19629 NNS denotes mice
T13024 19619-19620 -LRB- denotes (
T13025 19620-19621 SYM denotes -
T13026 19622-19623 SYM denotes -
T13027 19621-19622 HYPH denotes /
T13028 19623-19624 -RRB- denotes )
T13029 19630-19633 VBD denotes was
T13030 19644-19646 IN denotes by
T13031 19647-19654 NNP denotes Western
T13032 19655-19659 NN denotes blot
T13033 19660-19668 NN denotes analysis
T13034 19668-19669 . denotes .
T13035 19669-19889 sentence denotes To be brief, the cerebellum was isolated from a six month-old mouse of each genotype and homogenised in cell lysis buffer (50 mM Tris-HCl, pH 7.5, 100 mM NaCl, 1% NP-40, protease inhibitor cocktail [Roche Diagnostics]).
T13036 19670-19672 TO denotes To
T13037 19673-19675 VB denotes be
T13038 19702-19710 VBN denotes isolated
T13039 19676-19681 JJ denotes brief
T13040 19681-19683 , denotes ,
T13041 19683-19686 DT denotes the
T13042 19687-19697 NN denotes cerebellum
T13043 19698-19701 VBD denotes was
T13044 19711-19715 IN denotes from
T13045 19716-19717 DT denotes a
T13046 19732-19737 NN denotes mouse
T13047 19718-19721 CD denotes six
T13048 19722-19727 NN denotes month
T13049 19728-19731 JJ denotes old
T13050 19727-19728 HYPH denotes -
T13051 19738-19740 IN denotes of
T13052 19741-19745 DT denotes each
T13053 19746-19754 NN denotes genotype
T13054 19755-19758 CC denotes and
T13055 19759-19770 VBN denotes homogenised
T13056 19771-19773 IN denotes in
T13057 19774-19778 NN denotes cell
T13058 19779-19784 NN denotes lysis
T13059 19785-19791 NN denotes buffer
T13060 19792-19793 -LRB- denotes (
T13061 19859-19867 NN denotes cocktail
T13062 19793-19795 CD denotes 50
T13063 19796-19798 NN denotes mM
T13064 19804-19807 NN denotes HCl
T13065 19799-19803 NN denotes Tris
T13066 19803-19804 HYPH denotes -
T13067 19807-19809 , denotes ,
T13068 19809-19811 NN denotes pH
T13069 19812-19815 CD denotes 7.5
T13070 19815-19817 , denotes ,
T13071 19817-19820 CD denotes 100
T13072 19821-19823 NN denotes mM
T13073 19824-19828 NN denotes NaCl
T13074 19828-19830 , denotes ,
T13075 19830-19831 CD denotes 1
T13076 19831-19832 NN denotes %
T13077 19833-19835 NN denotes NP
T13078 19835-19836 HYPH denotes -
T13079 19836-19838 CD denotes 40
T13080 19838-19840 , denotes ,
T13081 19840-19848 NN denotes protease
T13082 19849-19858 NN denotes inhibitor
T13083 19868-19869 -LRB- denotes [
T13084 19875-19886 NNP denotes Diagnostics
T13085 19869-19874 NNP denotes Roche
T13086 19886-19887 -RRB- denotes ]
T13087 19887-19888 -RRB- denotes )
T13088 19888-19889 . denotes .
T13089 19889-20086 sentence denotes After removal of cell debris by centrifugation, the glycosylated proteins in the supernatant were concentrated by the affinity chromatography using Con A Sepharose 4B (Amersham Biosciences Corp.).
T13090 19890-19895 IN denotes After
T13091 19988-20000 VBN denotes concentrated
T13092 19896-19903 NN denotes removal
T13093 19904-19906 IN denotes of
T13094 19907-19911 NN denotes cell
T13095 19912-19918 NN denotes debris
T13096 19919-19921 IN denotes by
T13097 19922-19936 NN denotes centrifugation
T13098 19936-19938 , denotes ,
T13099 19938-19941 DT denotes the
T13100 19955-19963 NN denotes proteins
T13101 19942-19954 VBN denotes glycosylated
T13102 19964-19966 IN denotes in
T13103 19967-19970 DT denotes the
T13104 19971-19982 NN denotes supernatant
T13105 19983-19987 VBD denotes were
T13106 20001-20003 IN denotes by
T13107 20004-20007 DT denotes the
T13108 20017-20031 NN denotes chromatography
T13109 20008-20016 NN denotes affinity
T13110 20032-20037 VBG denotes using
T13111 20038-20041 NN denotes Con
T13112 20054-20056 NN denotes 4B
T13113 20042-20043 NN denotes A
T13114 20044-20053 NN denotes Sepharose
T13115 20057-20058 -LRB- denotes (
T13116 20079-20084 NNP denotes Corp.
T13117 20058-20066 NNP denotes Amersham
T13118 20067-20078 NNP denotes Biosciences
T13119 20084-20085 -RRB- denotes )
T13120 20085-20086 . denotes .
T13121 20086-20165 sentence denotes Each sample was separated on 10% SDS-PAGE, and transferred to a PVDF membrane.
T13122 20087-20091 DT denotes Each
T13123 20092-20098 NN denotes sample
T13124 20103-20112 VBN denotes separated
T13125 20099-20102 VBD denotes was
T13126 20113-20115 IN denotes on
T13127 20116-20118 CD denotes 10
T13128 20118-20119 NN denotes %
T13129 20124-20128 NN denotes PAGE
T13130 20120-20123 NN denotes SDS
T13131 20123-20124 HYPH denotes -
T13132 20128-20130 , denotes ,
T13133 20130-20133 CC denotes and
T13134 20134-20145 VBN denotes transferred
T13135 20146-20148 IN denotes to
T13136 20149-20150 DT denotes a
T13137 20156-20164 NN denotes membrane
T13138 20151-20155 NN denotes PVDF
T13139 20164-20165 . denotes .
T13140 20165-20274 sentence denotes The blot was then incubated with monoclonal antibody against the ADAM11 (U. S. Patent 5,631,351) at 1 μg/ml.
T13141 20166-20169 DT denotes The
T13142 20170-20174 NN denotes blot
T13143 20184-20193 VBN denotes incubated
T13144 20175-20178 VBD denotes was
T13145 20179-20183 RB denotes then
T13146 20194-20198 IN denotes with
T13147 20199-20209 JJ denotes monoclonal
T13148 20210-20218 NN denotes antibody
T13149 20219-20226 IN denotes against
T13150 20227-20230 DT denotes the
T13151 20231-20237 NN denotes ADAM11
T13152 20238-20239 -LRB- denotes (
T13153 20245-20251 NN denotes Patent
T13154 20239-20241 NNP denotes U.
T13155 20242-20244 NNP denotes S.
T13156 20252-20261 CD denotes 5,631,351
T13157 20261-20262 -RRB- denotes )
T13158 20263-20265 IN denotes at
T13159 20266-20267 CD denotes 1
T13160 20268-20270 NN denotes μg
T13161 20270-20271 SYM denotes /
T13162 20271-20273 NN denotes ml
T13163 20273-20274 . denotes .
T13164 20274-20441 sentence denotes Bound antibodies were visualised with horseradish peroxidase-labelled second antibody and an ECL-plus chemiluminescence detection system (Amersham Biosciences Corp.).
T13165 20275-20280 JJ denotes Bound
T13166 20281-20291 NNS denotes antibodies
T13167 20297-20307 VBN denotes visualised
T13168 20292-20296 VBD denotes were
T13169 20308-20312 IN denotes with
T13170 20313-20324 NN denotes horseradish
T13171 20325-20335 NN denotes peroxidase
T13172 20336-20344 VBN denotes labelled
T13173 20335-20336 HYPH denotes -
T13174 20352-20360 NN denotes antibody
T13175 20345-20351 JJ denotes second
T13176 20361-20364 CC denotes and
T13177 20365-20367 DT denotes an
T13178 20405-20411 NN denotes system
T13179 20368-20371 NN denotes ECL
T13180 20372-20376 NN denotes plus
T13181 20371-20372 HYPH denotes -
T13182 20377-20394 NN denotes chemiluminescence
T13183 20395-20404 NN denotes detection
T13184 20412-20413 -LRB- denotes (
T13185 20434-20439 NNP denotes Corp.
T13186 20413-20421 NNP denotes Amersham
T13187 20422-20433 NNP denotes Biosciences
T13188 20439-20440 -RRB- denotes )
T13189 20440-20441 . denotes .
T13416 20443-20454 JJ denotes Behavioural
T13417 20455-20463 NN denotes analysis
T13418 20463-20734 sentence denotes All animal procedures conformed to the Japanese regulations on animal care and use, following the Guideline for Animal Experimentation of the Japanese Association for Laboratory of Animal Science, and were approved by the Animal Care and Use Committee of Eisai Co., Ltd.
T13419 20464-20467 DT denotes All
T13420 20475-20485 NNS denotes procedures
T13421 20468-20474 NN denotes animal
T13422 20486-20495 VBD denotes conformed
T13423 20496-20498 IN denotes to
T13424 20499-20502 DT denotes the
T13425 20512-20523 NNS denotes regulations
T13426 20503-20511 JJ denotes Japanese
T13427 20524-20526 IN denotes on
T13428 20527-20533 NN denotes animal
T13429 20534-20538 NN denotes care
T13430 20539-20542 CC denotes and
T13431 20543-20546 NN denotes use
T13432 20546-20548 , denotes ,
T13433 20548-20557 VBG denotes following
T13434 20558-20561 DT denotes the
T13435 20562-20571 NNP denotes Guideline
T13436 20572-20575 IN denotes for
T13437 20576-20582 NNP denotes Animal
T13438 20583-20598 NNP denotes Experimentation
T13439 20599-20601 IN denotes of
T13440 20602-20605 DT denotes the
T13441 20615-20626 NNP denotes Association
T13442 20606-20614 NNP denotes Japanese
T13443 20627-20630 IN denotes for
T13444 20631-20641 NNP denotes Laboratory
T13445 20642-20644 IN denotes of
T13446 20645-20651 NNP denotes Animal
T13447 20652-20659 NNP denotes Science
T13448 20659-20661 , denotes ,
T13449 20661-20664 CC denotes and
T13450 20665-20669 VBD denotes were
T13451 20670-20678 VBN denotes approved
T13452 20679-20681 IN denotes by
T13453 20682-20685 DT denotes the
T13454 20706-20715 NNP denotes Committee
T13455 20686-20692 NNP denotes Animal
T13456 20693-20697 NNP denotes Care
T13457 20698-20701 CC denotes and
T13458 20702-20705 NNP denotes Use
T13459 20716-20718 IN denotes of
T13460 20719-20724 NNP denotes Eisai
T13461 20725-20728 NNP denotes Co.
T13462 20728-20730 , denotes ,
T13463 20730-20733 NNP denotes Ltd
T13464 20733-20734 . denotes .
T13465 20734-20901 sentence denotes For the present experiments, ADAM11-deficient male mice (backcrossed generations into C57BL/6NCrj, n = 14) were used in all behavioural analyses (22–24 weeks of age).
T13466 20735-20738 IN denotes For
T13467 20847-20851 VBN denotes used
T13468 20739-20742 DT denotes the
T13469 20751-20762 NNS denotes experiments
T13470 20743-20750 JJ denotes present
T13471 20762-20764 , denotes ,
T13472 20764-20770 NN denotes ADAM11
T13473 20771-20780 JJ denotes deficient
T13474 20770-20771 HYPH denotes -
T13475 20786-20790 NNS denotes mice
T13476 20781-20785 JJ denotes male
T13477 20791-20792 -LRB- denotes (
T13478 20804-20815 NNS denotes generations
T13479 20792-20803 VBN denotes backcrossed
T13480 20816-20820 IN denotes into
T13481 20821-20826 NN denotes C57BL
T13482 20827-20832 NN denotes 6NCrj
T13483 20826-20827 HYPH denotes /
T13484 20832-20834 , denotes ,
T13485 20834-20835 NN denotes n
T13486 20838-20840 CD denotes 14
T13487 20836-20837 SYM denotes =
T13488 20840-20841 -RRB- denotes )
T13489 20842-20846 VBD denotes were
T13490 20852-20854 IN denotes in
T13491 20855-20858 DT denotes all
T13492 20871-20879 NNS denotes analyses
T13493 20859-20870 JJ denotes behavioural
T13494 20880-20881 -LRB- denotes (
T13495 20887-20892 NNS denotes weeks
T13496 20881-20883 CD denotes 22
T13497 20884-20886 CD denotes 24
T13498 20883-20884 SYM denotes –
T13499 20893-20895 IN denotes of
T13500 20896-20899 NN denotes age
T13501 20899-20900 -RRB- denotes )
T13502 20900-20901 . denotes .
T13503 20901-21032 sentence denotes All of the behavioural studies were conducted between 10:00 and 16:00 by a well-trained experimenter blind to the mouse genotypes.
T13504 20902-20905 DT denotes All
T13505 20938-20947 VBN denotes conducted
T13506 20906-20908 IN denotes of
T13507 20909-20912 DT denotes the
T13508 20925-20932 NNS denotes studies
T13509 20913-20924 JJ denotes behavioural
T13510 20933-20937 VBD denotes were
T13511 20948-20955 IN denotes between
T13512 20956-20958 CD denotes 10
T13513 20959-20961 CD denotes 00
T13514 20958-20959 : denotes :
T13515 20962-20965 CC denotes and
T13516 20966-20968 CD denotes 16
T13517 20969-20971 CD denotes 00
T13518 20968-20969 : denotes :
T13519 20972-20974 IN denotes by
T13520 20975-20976 DT denotes a
T13521 20990-21002 NN denotes experimenter
T13522 20977-20981 RB denotes well
T13523 20982-20989 VBN denotes trained
T13524 20981-20982 HYPH denotes -
T13525 21003-21008 JJ denotes blind
T13526 21009-21011 IN denotes to
T13527 21012-21015 DT denotes the
T13528 21022-21031 NNS denotes genotypes
T13529 21016-21021 NN denotes mouse
T13530 21031-21032 . denotes .
T13661 21034-21045 JJ denotes Spontaneous
T13662 21052-21060 NN denotes activity
T13663 21046-21051 NN denotes motor
T13664 21060-21303 sentence denotes Locomotor activity in a novel environment was measured by introducing mice (+/+, +/- and -/-; n = 8, 8 and 8, respectively) for 90 min in a Plexiglas box (30 × 20 × 13 cm) using a VERSAMAX equipment and software (Accuscan, Columbus, OH, USA).
T13665 21061-21070 NN denotes Locomotor
T13666 21071-21079 NN denotes activity
T13667 21107-21115 VBN denotes measured
T13668 21080-21082 IN denotes in
T13669 21083-21084 DT denotes a
T13670 21091-21102 NN denotes environment
T13671 21085-21090 JJ denotes novel
T13672 21103-21106 VBD denotes was
T13673 21116-21118 IN denotes by
T13674 21119-21130 VBG denotes introducing
T13675 21131-21135 NNS denotes mice
T13676 21136-21137 -LRB- denotes (
T13677 21139-21140 SYM denotes +
T13678 21137-21138 SYM denotes +
T13679 21138-21139 HYPH denotes /
T13680 21140-21142 , denotes ,
T13681 21142-21143 SYM denotes +
T13682 21144-21145 SYM denotes -
T13683 21143-21144 HYPH denotes /
T13684 21146-21149 CC denotes and
T13685 21150-21151 SYM denotes -
T13686 21152-21153 SYM denotes -
T13687 21151-21152 HYPH denotes /
T13688 21153-21154 : denotes ;
T13689 21155-21156 NN denotes n
T13690 21159-21160 CD denotes 8
T13691 21157-21158 SYM denotes =
T13692 21160-21162 , denotes ,
T13693 21162-21163 CD denotes 8
T13694 21164-21167 CC denotes and
T13695 21168-21169 CD denotes 8
T13696 21169-21171 , denotes ,
T13697 21171-21183 RB denotes respectively
T13698 21183-21184 -RRB- denotes )
T13699 21185-21188 IN denotes for
T13700 21189-21191 CD denotes 90
T13701 21192-21195 NN denotes min
T13702 21196-21198 IN denotes in
T13703 21199-21200 DT denotes a
T13704 21211-21214 NN denotes box
T13705 21201-21210 NN denotes Plexiglas
T13706 21215-21216 -LRB- denotes (
T13707 21229-21231 NN denotes cm
T13708 21216-21218 CD denotes 30
T13709 21219-21220 SYM denotes ×
T13710 21221-21223 CD denotes 20
T13711 21224-21225 SYM denotes ×
T13712 21226-21228 CD denotes 13
T13713 21231-21232 -RRB- denotes )
T13714 21233-21238 VBG denotes using
T13715 21239-21240 DT denotes a
T13716 21250-21259 NN denotes equipment
T13717 21241-21249 NNP denotes VERSAMAX
T13718 21260-21263 CC denotes and
T13719 21264-21272 NN denotes software
T13720 21273-21274 -LRB- denotes (
T13721 21274-21282 NNP denotes Accuscan
T13722 21282-21284 , denotes ,
T13723 21284-21292 NNP denotes Columbus
T13724 21292-21294 , denotes ,
T13725 21294-21296 NNP denotes OH
T13726 21296-21298 , denotes ,
T13727 21298-21301 NNP denotes USA
T13728 21301-21302 -RRB- denotes )
T13729 21302-21303 . denotes .
T14364 21305-21310 NN denotes Water
T14365 21311-21315 NN denotes maze
T14366 21316-21320 NN denotes task
T14367 21320-21421 sentence denotes Spatial learning was assessed by three variants of the Morris water maze task [27] adapted for mice.
T14368 21321-21328 JJ denotes Spatial
T14369 21329-21337 NN denotes learning
T14370 21342-21350 VBN denotes assessed
T14371 21338-21341 VBD denotes was
T14372 21351-21353 IN denotes by
T14373 21354-21359 CD denotes three
T14374 21360-21368 NNS denotes variants
T14375 21369-21371 IN denotes of
T14376 21372-21375 DT denotes the
T14377 21394-21398 NN denotes task
T14378 21376-21382 NNP denotes Morris
T14379 21383-21388 NN denotes water
T14380 21389-21393 NN denotes maze
T14381 21399-21400 -LRB- denotes [
T14382 21400-21402 CD denotes 27
T14383 21402-21403 -RRB- denotes ]
T14384 21404-21411 VBN denotes adapted
T14385 21412-21415 IN denotes for
T14386 21416-21420 NNS denotes mice
T14387 21420-21421 . denotes .
T14388 21421-21581 sentence denotes Hidden platform task: The pool was divided into four quadrants with four starting locations, called north, east, south and west, at equal distances to the rim.
T14389 21422-21428 JJ denotes Hidden
T14390 21438-21442 NN denotes task
T14391 21429-21437 NN denotes platform
T14392 21457-21464 VBN denotes divided
T14393 21442-21444 : denotes :
T14394 21444-21447 DT denotes The
T14395 21448-21452 NN denotes pool
T14396 21453-21456 VBD denotes was
T14397 21465-21469 IN denotes into
T14398 21470-21474 CD denotes four
T14399 21475-21484 NNS denotes quadrants
T14400 21485-21489 IN denotes with
T14401 21551-21553 IN denotes at
T14402 21490-21494 CD denotes four
T14403 21504-21513 NNS denotes locations
T14404 21495-21503 NN denotes starting
T14405 21513-21515 , denotes ,
T14406 21515-21521 VBN denotes called
T14407 21522-21527 NN denotes north
T14408 21527-21529 , denotes ,
T14409 21529-21533 NN denotes east
T14410 21533-21535 , denotes ,
T14411 21535-21540 NN denotes south
T14412 21541-21544 CC denotes and
T14413 21545-21549 NN denotes west
T14414 21549-21551 , denotes ,
T14415 21554-21559 JJ denotes equal
T14416 21560-21569 NNS denotes distances
T14417 21570-21572 IN denotes to
T14418 21573-21576 DT denotes the
T14419 21577-21580 NN denotes rim
T14420 21580-21581 . denotes .
T14421 21581-21757 sentence denotes A circular, transparent acrylic platform (diameter 8 cm) was submerged 1 cm below the surface of the water in the centre of the southeast quadrant for each trial of this task.
T14422 21582-21583 DT denotes A
T14423 21614-21622 NN denotes platform
T14424 21584-21592 JJ denotes circular
T14425 21592-21594 , denotes ,
T14426 21594-21605 JJ denotes transparent
T14427 21606-21613 JJ denotes acrylic
T14428 21643-21652 VBN denotes submerged
T14429 21623-21624 -LRB- denotes (
T14430 21635-21637 NN denotes cm
T14431 21624-21632 NN denotes diameter
T14432 21633-21634 CD denotes 8
T14433 21637-21638 -RRB- denotes )
T14434 21639-21642 VBD denotes was
T14435 21653-21654 CD denotes 1
T14436 21655-21657 NN denotes cm
T14437 21658-21663 IN denotes below
T14438 21664-21667 DT denotes the
T14439 21668-21675 NN denotes surface
T14440 21676-21678 IN denotes of
T14441 21679-21682 DT denotes the
T14442 21683-21688 NN denotes water
T14443 21689-21691 IN denotes in
T14444 21692-21695 DT denotes the
T14445 21696-21702 NN denotes centre
T14446 21703-21705 IN denotes of
T14447 21706-21709 DT denotes the
T14448 21720-21728 NN denotes quadrant
T14449 21710-21719 NN denotes southeast
T14450 21729-21732 IN denotes for
T14451 21733-21737 DT denotes each
T14452 21738-21743 NN denotes trial
T14453 21744-21746 IN denotes of
T14454 21747-21751 DT denotes this
T14455 21752-21756 NN denotes task
T14456 21756-21757 . denotes .
T14457 21757-21888 sentence denotes Each mouse was allowed to swim for 60 sec and the time required to reach the platform (escape latency) was recorded in each trial.
T14458 21758-21762 DT denotes Each
T14459 21763-21768 NN denotes mouse
T14460 21773-21780 VBN denotes allowed
T14461 21769-21772 VBD denotes was
T14462 21781-21783 TO denotes to
T14463 21784-21788 VB denotes swim
T14464 21789-21792 IN denotes for
T14465 21793-21795 CD denotes 60
T14466 21796-21799 NN denotes sec
T14467 21800-21803 CC denotes and
T14468 21804-21807 DT denotes the
T14469 21808-21812 NN denotes time
T14470 21865-21873 VBN denotes recorded
T14471 21813-21821 VBN denotes required
T14472 21822-21824 TO denotes to
T14473 21825-21830 VB denotes reach
T14474 21831-21834 DT denotes the
T14475 21835-21843 NN denotes platform
T14476 21844-21845 -LRB- denotes (
T14477 21845-21851 NN denotes escape
T14478 21852-21859 NN denotes latency
T14479 21859-21860 -RRB- denotes )
T14480 21861-21864 VBD denotes was
T14481 21874-21876 IN denotes in
T14482 21877-21881 DT denotes each
T14483 21882-21887 NN denotes trial
T14484 21887-21888 . denotes .
T14485 21888-21983 sentence denotes In total this task consisted of four trials per day over 9 days (1 min inter-trial intervals).
T14486 21889-21891 IN denotes In
T14487 21908-21917 VBD denotes consisted
T14488 21892-21897 JJ denotes total
T14489 21898-21902 DT denotes this
T14490 21903-21907 NN denotes task
T14491 21918-21920 IN denotes of
T14492 21921-21925 CD denotes four
T14493 21926-21932 NNS denotes trials
T14494 21933-21936 IN denotes per
T14495 21937-21940 NN denotes day
T14496 21941-21945 IN denotes over
T14497 21946-21947 CD denotes 9
T14498 21948-21952 NNS denotes days
T14499 21953-21954 -LRB- denotes (
T14500 21972-21981 NNS denotes intervals
T14501 21954-21955 CD denotes 1
T14502 21956-21959 NN denotes min
T14503 21960-21971 JJ denotes inter-trial
T14504 21981-21982 -RRB- denotes )
T14505 21982-21983 . denotes .
T14506 21983-22077 sentence denotes Each trial was initiated by randomly placing an animal in one of the four starting locations.
T14507 21984-21988 DT denotes Each
T14508 21989-21994 NN denotes trial
T14509 21999-22008 VBN denotes initiated
T14510 21995-21998 VBD denotes was
T14511 22009-22011 IN denotes by
T14512 22012-22020 RB denotes randomly
T14513 22021-22028 VBG denotes placing
T14514 22029-22031 DT denotes an
T14515 22032-22038 NN denotes animal
T14516 22039-22041 IN denotes in
T14517 22042-22045 CD denotes one
T14518 22046-22048 IN denotes of
T14519 22049-22052 DT denotes the
T14520 22067-22076 NNS denotes locations
T14521 22053-22057 CD denotes four
T14522 22058-22066 NN denotes starting
T14523 22076-22077 . denotes .
T14524 22077-22178 sentence denotes Probe trial: A single probe trial was carried out after the hidden platform task had been completed.
T14525 22078-22083 NN denotes Probe
T14526 22084-22089 NN denotes trial
T14527 22116-22123 VBN denotes carried
T14528 22089-22091 : denotes :
T14529 22091-22092 DT denotes A
T14530 22106-22111 NN denotes trial
T14531 22093-22099 JJ denotes single
T14532 22100-22105 NN denotes probe
T14533 22112-22115 VBD denotes was
T14534 22124-22127 RP denotes out
T14535 22128-22133 IN denotes after
T14536 22168-22177 VBN denotes completed
T14537 22134-22137 DT denotes the
T14538 22154-22158 NN denotes task
T14539 22138-22144 JJ denotes hidden
T14540 22145-22153 NN denotes platform
T14541 22159-22162 VBD denotes had
T14542 22163-22167 VBN denotes been
T14543 22177-22178 . denotes .
T14544 22178-22358 sentence denotes In this trial, the platform was removed and the movement of each mouse was monitored using a computer-based video tracking system (BTA-2; Muromachi Kikai Co., Ltd., Tokyo, Japan).
T14545 22179-22181 IN denotes In
T14546 22211-22218 VBN denotes removed
T14547 22182-22186 DT denotes this
T14548 22187-22192 NN denotes trial
T14549 22192-22194 , denotes ,
T14550 22194-22197 DT denotes the
T14551 22198-22206 NN denotes platform
T14552 22207-22210 VBD denotes was
T14553 22219-22222 CC denotes and
T14554 22223-22226 DT denotes the
T14555 22227-22235 NN denotes movement
T14556 22254-22263 VBN denotes monitored
T14557 22236-22238 IN denotes of
T14558 22239-22243 DT denotes each
T14559 22244-22249 NN denotes mouse
T14560 22250-22253 VBD denotes was
T14561 22264-22269 VBG denotes using
T14562 22270-22271 DT denotes a
T14563 22302-22308 NN denotes system
T14564 22272-22280 NN denotes computer
T14565 22281-22286 VBN denotes based
T14566 22280-22281 HYPH denotes -
T14567 22287-22292 NN denotes video
T14568 22293-22301 NN denotes tracking
T14569 22309-22310 -LRB- denotes (
T14570 22333-22336 NNP denotes Co.
T14571 22310-22313 NN denotes BTA
T14572 22313-22314 HYPH denotes -
T14573 22314-22315 CD denotes 2
T14574 22315-22316 : denotes ;
T14575 22317-22326 NNP denotes Muromachi
T14576 22327-22332 NNP denotes Kikai
T14577 22336-22338 , denotes ,
T14578 22338-22342 NNP denotes Ltd.
T14579 22342-22344 , denotes ,
T14580 22344-22349 NNP denotes Tokyo
T14581 22349-22351 , denotes ,
T14582 22351-22356 NNP denotes Japan
T14583 22356-22357 -RRB- denotes )
T14584 22357-22358 . denotes .
T14585 22358-22452 sentence denotes Each mouse was placed into the northwest quadrant of the pool and allowed to swim for 60 sec.
T14586 22359-22363 DT denotes Each
T14587 22364-22369 NN denotes mouse
T14588 22374-22380 VBN denotes placed
T14589 22370-22373 VBD denotes was
T14590 22381-22385 IN denotes into
T14591 22386-22389 DT denotes the
T14592 22400-22408 NN denotes quadrant
T14593 22390-22399 NN denotes northwest
T14594 22409-22411 IN denotes of
T14595 22412-22415 DT denotes the
T14596 22416-22420 NN denotes pool
T14597 22421-22424 CC denotes and
T14598 22425-22432 VBN denotes allowed
T14599 22433-22435 TO denotes to
T14600 22436-22440 VB denotes swim
T14601 22441-22444 IN denotes for
T14602 22445-22447 CD denotes 60
T14603 22448-22451 NN denotes sec
T14604 22451-22452 . denotes .
T14605 22452-22541 sentence denotes Swim path length and the time spent in the trained (southeast) quadrant were calculated.
T14606 22453-22457 NN denotes Swim
T14607 22458-22462 NN denotes path
T14608 22463-22469 NN denotes length
T14609 22530-22540 VBN denotes calculated
T14610 22470-22473 CC denotes and
T14611 22474-22477 DT denotes the
T14612 22478-22482 NN denotes time
T14613 22483-22488 VBN denotes spent
T14614 22489-22491 IN denotes in
T14615 22492-22495 DT denotes the
T14616 22516-22524 NN denotes quadrant
T14617 22496-22503 VBN denotes trained
T14618 22504-22505 -LRB- denotes (
T14619 22505-22514 NN denotes southeast
T14620 22514-22515 -RRB- denotes )
T14621 22525-22529 VBD denotes were
T14622 22540-22541 . denotes .
T14623 22541-22709 sentence denotes Visible platform task: In this task, the circular platform was made visible by attaching a black board to it and the mouse was required to locate the visible platform.
T14624 22542-22549 JJ denotes Visible
T14625 22559-22563 NN denotes task
T14626 22550-22558 NN denotes platform
T14627 22605-22609 VBN denotes made
T14628 22563-22565 : denotes :
T14629 22565-22567 IN denotes In
T14630 22568-22572 DT denotes this
T14631 22573-22577 NN denotes task
T14632 22577-22579 , denotes ,
T14633 22579-22582 DT denotes the
T14634 22592-22600 NN denotes platform
T14635 22583-22591 JJ denotes circular
T14636 22601-22604 VBD denotes was
T14637 22610-22617 JJ denotes visible
T14638 22618-22620 IN denotes by
T14639 22621-22630 VBG denotes attaching
T14640 22631-22632 DT denotes a
T14641 22639-22644 NN denotes board
T14642 22633-22638 JJ denotes black
T14643 22645-22647 IN denotes to
T14644 22648-22650 PRP denotes it
T14645 22651-22654 CC denotes and
T14646 22655-22658 DT denotes the
T14647 22659-22664 NN denotes mouse
T14648 22669-22677 VBN denotes required
T14649 22665-22668 VBD denotes was
T14650 22678-22680 TO denotes to
T14651 22681-22687 VB denotes locate
T14652 22688-22691 DT denotes the
T14653 22700-22708 NN denotes platform
T14654 22692-22699 JJ denotes visible
T14655 22708-22709 . denotes .
T14656 22709-22855 sentence denotes The mouse was allowed to swim for 60 sec and this task consisted of four trials per day for three consecutive days (1 min inter-trial intervals).
T14657 22710-22713 DT denotes The
T14658 22714-22719 NN denotes mouse
T14659 22724-22731 VBN denotes allowed
T14660 22720-22723 VBD denotes was
T14661 22732-22734 TO denotes to
T14662 22735-22739 VB denotes swim
T14663 22740-22743 IN denotes for
T14664 22744-22746 CD denotes 60
T14665 22747-22750 NN denotes sec
T14666 22751-22754 CC denotes and
T14667 22755-22759 DT denotes this
T14668 22760-22764 NN denotes task
T14669 22765-22774 VBD denotes consisted
T14670 22775-22777 IN denotes of
T14671 22778-22782 CD denotes four
T14672 22783-22789 NNS denotes trials
T14673 22790-22793 IN denotes per
T14674 22794-22797 NN denotes day
T14675 22798-22801 IN denotes for
T14676 22802-22807 CD denotes three
T14677 22820-22824 NNS denotes days
T14678 22808-22819 JJ denotes consecutive
T14679 22825-22826 -LRB- denotes (
T14680 22844-22853 NNS denotes intervals
T14681 22826-22827 CD denotes 1
T14682 22828-22831 NN denotes min
T14683 22832-22843 JJ denotes inter-trial
T14684 22853-22854 -RRB- denotes )
T14685 22854-22855 . denotes .
T14686 22855-22949 sentence denotes Each trial was initiated by randomly placing an animal in one of the four starting locations.
T14687 22856-22860 DT denotes Each
T14688 22861-22866 NN denotes trial
T14689 22871-22880 VBN denotes initiated
T14690 22867-22870 VBD denotes was
T14691 22881-22883 IN denotes by
T14692 22884-22892 RB denotes randomly
T14693 22893-22900 VBG denotes placing
T14694 22901-22903 DT denotes an
T14695 22904-22910 NN denotes animal
T14696 22911-22913 IN denotes in
T14697 22914-22917 CD denotes one
T14698 22918-22920 IN denotes of
T14699 22921-22924 DT denotes the
T14700 22939-22948 NNS denotes locations
T14701 22925-22929 CD denotes four
T14702 22930-22938 NN denotes starting
T14703 22948-22949 . denotes .
T14924 22951-22959 VBG denotes Rotating
T14925 22960-22963 NN denotes rod
T14926 22964-22968 NN denotes test
T14927 22968-23200 sentence denotes Motor coordination was assessed with a rotating rod apparatus (KN-75, Natsume Seisakujo, Tokyo, Japan), which consisted of a plastic rod (3 cm diameter, 8 cm long) with a gritted surface flanked by two large discs (40 cm diameter).
T14928 22969-22974 NN denotes Motor
T14929 22975-22987 NN denotes coordination
T14930 22992-23000 VBN denotes assessed
T14931 22988-22991 VBD denotes was
T14932 23001-23005 IN denotes with
T14933 23006-23007 DT denotes a
T14934 23021-23030 NN denotes apparatus
T14935 23008-23016 VBG denotes rotating
T14936 23017-23020 NN denotes rod
T14937 23031-23032 -LRB- denotes (
T14938 23047-23056 NNP denotes Seisakujo
T14939 23032-23034 NN denotes KN
T14940 23034-23035 HYPH denotes -
T14941 23035-23037 CD denotes 75
T14942 23037-23039 , denotes ,
T14943 23039-23046 NNP denotes Natsume
T14944 23056-23058 , denotes ,
T14945 23058-23063 NNP denotes Tokyo
T14946 23063-23065 , denotes ,
T14947 23065-23070 NNP denotes Japan
T14948 23070-23071 -RRB- denotes )
T14949 23071-23073 , denotes ,
T14950 23073-23078 WDT denotes which
T14951 23079-23088 VBD denotes consisted
T14952 23089-23091 IN denotes of
T14953 23092-23093 DT denotes a
T14954 23102-23105 NN denotes rod
T14955 23094-23101 NN denotes plastic
T14956 23106-23107 -LRB- denotes (
T14957 23112-23120 NN denotes diameter
T14958 23107-23108 CD denotes 3
T14959 23109-23111 NN denotes cm
T14960 23120-23122 , denotes ,
T14961 23122-23123 CD denotes 8
T14962 23124-23126 NN denotes cm
T14963 23127-23131 JJ denotes long
T14964 23131-23132 -RRB- denotes )
T14965 23133-23137 IN denotes with
T14966 23138-23139 DT denotes a
T14967 23148-23155 NN denotes surface
T14968 23140-23147 JJ denotes gritted
T14969 23156-23163 VBN denotes flanked
T14970 23164-23166 IN denotes by
T14971 23167-23170 CD denotes two
T14972 23177-23182 NNS denotes discs
T14973 23171-23176 JJ denotes large
T14974 23183-23184 -LRB- denotes (
T14975 23190-23198 NN denotes diameter
T14976 23184-23186 CD denotes 40
T14977 23187-23189 NN denotes cm
T14978 23198-23199 -RRB- denotes )
T14979 23199-23200 . denotes .
T14980 23200-23384 sentence denotes The mice were first placed on the stationary rod for 4 successive trials, followed by 4 trials at a rotation speed of 5 rpm, 8 trials at 10 rpm, and 20 trials at 15 rpm in that order.
T14981 23201-23204 DT denotes The
T14982 23205-23209 NNS denotes mice
T14983 23221-23227 VBN denotes placed
T14984 23210-23214 VBD denotes were
T14985 23215-23220 RB denotes first
T14986 23228-23230 IN denotes on
T14987 23231-23234 DT denotes the
T14988 23246-23249 NN denotes rod
T14989 23235-23245 JJ denotes stationary
T14990 23250-23253 IN denotes for
T14991 23254-23255 CD denotes 4
T14992 23267-23273 NNS denotes trials
T14993 23256-23266 JJ denotes successive
T14994 23273-23275 , denotes ,
T14995 23275-23283 VBN denotes followed
T14996 23284-23286 IN denotes by
T14997 23287-23288 CD denotes 4
T14998 23289-23295 NNS denotes trials
T14999 23296-23298 IN denotes at
T15000 23299-23300 DT denotes a
T15001 23310-23315 NN denotes speed
T15002 23301-23309 NN denotes rotation
T15003 23316-23318 IN denotes of
T15004 23319-23320 CD denotes 5
T15005 23321-23324 NN denotes rpm
T15006 23324-23326 , denotes ,
T15007 23326-23327 CD denotes 8
T15008 23328-23334 NNS denotes trials
T15009 23335-23337 IN denotes at
T15010 23338-23340 CD denotes 10
T15011 23341-23344 NN denotes rpm
T15012 23344-23346 , denotes ,
T15013 23346-23349 CC denotes and
T15014 23350-23352 CD denotes 20
T15015 23353-23359 NNS denotes trials
T15016 23360-23362 IN denotes at
T15017 23363-23365 CD denotes 15
T15018 23366-23369 NN denotes rpm
T15019 23370-23372 IN denotes in
T15020 23373-23377 DT denotes that
T15021 23378-23383 NN denotes order
T15022 23383-23384 . denotes .
T15023 23384-23441 sentence denotes Latency until a fall occurred was monitored for 120 sec.
T15024 23385-23392 NN denotes Latency
T15025 23419-23428 VBN denotes monitored
T15026 23393-23398 IN denotes until
T15027 23406-23414 VBD denotes occurred
T15028 23399-23400 DT denotes a
T15029 23401-23405 NN denotes fall
T15030 23415-23418 VBD denotes was
T15031 23429-23432 IN denotes for
T15032 23433-23436 CD denotes 120
T15033 23437-23440 NN denotes sec
T15034 23440-23441 . denotes .
T15035 23441-23502 sentence denotes Intra-trial intervals for each animal were more than 20 min.
T15036 23442-23453 JJ denotes Intra-trial
T15037 23454-23463 NNS denotes intervals
T15038 23480-23484 VBD denotes were
T15039 23464-23467 IN denotes for
T15040 23468-23472 DT denotes each
T15041 23473-23479 NN denotes animal
T15042 23485-23489 JJR denotes more
T15043 23495-23497 CD denotes 20
T15044 23490-23494 IN denotes than
T15045 23498-23501 NN denotes min
T15046 23501-23502 . denotes .
T15164 23504-23512 NN denotes Traction
T15165 23513-23517 NN denotes test
T15166 23517-23623 sentence denotes The grip strength of each mouse was measured with a traction apparatus (FU-1, Muromachi Kikai Co., Ltd.).
T15167 23518-23521 DT denotes The
T15168 23527-23535 NN denotes strength
T15169 23522-23526 NN denotes grip
T15170 23554-23562 VBN denotes measured
T15171 23536-23538 IN denotes of
T15172 23539-23543 DT denotes each
T15173 23544-23549 NN denotes mouse
T15174 23550-23553 VBD denotes was
T15175 23563-23567 IN denotes with
T15176 23568-23569 DT denotes a
T15177 23579-23588 NN denotes apparatus
T15178 23570-23578 NN denotes traction
T15179 23589-23590 -LRB- denotes (
T15180 23612-23615 NNP denotes Co.
T15181 23590-23592 NN denotes FU
T15182 23592-23593 HYPH denotes -
T15183 23593-23594 CD denotes 1
T15184 23594-23596 , denotes ,
T15185 23596-23605 NNP denotes Muromachi
T15186 23606-23611 NNP denotes Kikai
T15187 23615-23617 , denotes ,
T15188 23617-23621 NNP denotes Ltd.
T15189 23621-23622 -RRB- denotes )
T15190 23622-23623 . denotes .
T15191 23623-23743 sentence denotes Each mouse was made to grasp the attached bar (2 mm diameter) with the forepaws and was slowly pulled back by the tail.
T15192 23624-23628 DT denotes Each
T15193 23629-23634 NN denotes mouse
T15194 23639-23643 VBN denotes made
T15195 23635-23638 VBD denotes was
T15196 23644-23646 TO denotes to
T15197 23647-23652 VB denotes grasp
T15198 23653-23656 DT denotes the
T15199 23666-23669 NN denotes bar
T15200 23657-23665 VBN denotes attached
T15201 23670-23671 -LRB- denotes (
T15202 23676-23684 NN denotes diameter
T15203 23671-23672 CD denotes 2
T15204 23673-23675 NN denotes mm
T15205 23684-23685 -RRB- denotes )
T15206 23686-23690 IN denotes with
T15207 23691-23694 DT denotes the
T15208 23695-23703 NNS denotes forepaws
T15209 23704-23707 CC denotes and
T15210 23708-23711 VBD denotes was
T15211 23719-23725 VBN denotes pulled
T15212 23712-23718 RB denotes slowly
T15213 23726-23730 RB denotes back
T15214 23731-23733 IN denotes by
T15215 23734-23737 DT denotes the
T15216 23738-23742 NN denotes tail
T15217 23742-23743 . denotes .
T15218 23743-23792 sentence denotes The maximum tension before release was recorded.
T15219 23744-23747 DT denotes The
T15220 23756-23763 NN denotes tension
T15221 23748-23755 JJ denotes maximum
T15222 23783-23791 VBN denotes recorded
T15223 23764-23770 IN denotes before
T15224 23771-23778 NN denotes release
T15225 23779-23782 VBD denotes was
T15226 23791-23792 . denotes .
T15486 23794-23798 NN denotes Wire
T15487 23799-23809 NN denotes suspension
T15488 23810-23814 NN denotes test
T15489 23814-24007 sentence denotes A mouse was placed on a stainless bar (50 cm length, 2 mm diameter, elevated up to 37 cm from a surface) at a point midway between the supports and observed for 30 sec in four separate trials.
T15490 23815-23816 DT denotes A
T15491 23817-23822 NN denotes mouse
T15492 23827-23833 VBN denotes placed
T15493 23823-23826 VBD denotes was
T15494 23834-23836 IN denotes on
T15495 23837-23838 DT denotes a
T15496 23849-23852 NN denotes bar
T15497 23839-23848 JJ denotes stainless
T15498 23853-23854 -LRB- denotes (
T15499 23873-23881 NN denotes diameter
T15500 23854-23856 CD denotes 50
T15501 23857-23859 NN denotes cm
T15502 23860-23866 NN denotes length
T15503 23866-23868 , denotes ,
T15504 23868-23869 CD denotes 2
T15505 23870-23872 NN denotes mm
T15506 23881-23883 , denotes ,
T15507 23883-23891 VBN denotes elevated
T15508 23892-23894 RB denotes up
T15509 23898-23900 CD denotes 37
T15510 23895-23897 IN denotes to
T15511 23901-23903 NN denotes cm
T15512 23904-23908 IN denotes from
T15513 23909-23910 DT denotes a
T15514 23911-23918 NN denotes surface
T15515 23918-23919 -RRB- denotes )
T15516 23920-23922 IN denotes at
T15517 23923-23924 DT denotes a
T15518 23931-23937 NN denotes midway
T15519 23925-23930 NN denotes point
T15520 23938-23945 IN denotes between
T15521 23946-23949 DT denotes the
T15522 23950-23958 NNS denotes supports
T15523 23959-23962 CC denotes and
T15524 23963-23971 VBN denotes observed
T15525 23972-23975 IN denotes for
T15526 23976-23978 CD denotes 30
T15527 23979-23982 NN denotes sec
T15528 23983-23985 IN denotes in
T15529 23986-23990 CD denotes four
T15530 24000-24006 NNS denotes trials
T15531 23991-23999 JJ denotes separate
T15532 24006-24007 . denotes .
T15533 24007-24386 sentence denotes The amount of time spent hanging was recorded and scored according to the following system [41]: 0, fell off; 1, hung onto the bar with two forepaws; 2, in addition to 1, attempted to climb onto the bar; 3, hung onto the bar with two forepaws and one or both hind paws; 4, hung onto the bar with all four paws with tail wrapped around the bar; 5, escaped to one of the supports.
T15534 24008-24011 DT denotes The
T15535 24012-24018 NN denotes amount
T15536 24045-24053 VBN denotes recorded
T15537 24019-24021 IN denotes of
T15538 24022-24026 NN denotes time
T15539 24027-24032 VBN denotes spent
T15540 24033-24040 VBG denotes hanging
T15541 24041-24044 VBD denotes was
T15542 24054-24057 CC denotes and
T15543 24058-24064 VBN denotes scored
T15544 24065-24074 VBG denotes according
T15545 24075-24077 IN denotes to
T15546 24078-24081 DT denotes the
T15547 24092-24098 NN denotes system
T15548 24082-24091 VBG denotes following
T15549 24099-24100 -LRB- denotes [
T15550 24100-24102 CD denotes 41
T15551 24102-24103 -RRB- denotes ]
T15552 24103-24105 : denotes :
T15553 24105-24106 CD denotes 0
T15554 24108-24112 VBD denotes fell
T15555 24106-24108 , denotes ,
T15556 24355-24362 VBD denotes escaped
T15557 24113-24116 RP denotes off
T15558 24116-24117 : denotes ;
T15559 24118-24119 CD denotes 1
T15560 24121-24125 VBD denotes hung
T15561 24119-24121 , denotes ,
T15562 24126-24130 IN denotes onto
T15563 24131-24134 DT denotes the
T15564 24135-24138 NN denotes bar
T15565 24139-24143 IN denotes with
T15566 24144-24147 CD denotes two
T15567 24148-24156 NNS denotes forepaws
T15568 24156-24157 : denotes ;
T15569 24158-24159 CD denotes 2
T15570 24179-24188 VBD denotes attempted
T15571 24159-24161 , denotes ,
T15572 24161-24163 IN denotes in
T15573 24164-24172 NN denotes addition
T15574 24173-24175 IN denotes to
T15575 24176-24177 CD denotes 1
T15576 24177-24179 , denotes ,
T15577 24189-24191 TO denotes to
T15578 24192-24197 VB denotes climb
T15579 24198-24202 IN denotes onto
T15580 24203-24206 DT denotes the
T15581 24207-24210 NN denotes bar
T15582 24210-24211 : denotes ;
T15583 24212-24213 CD denotes 3
T15584 24215-24219 VBD denotes hung
T15585 24213-24215 , denotes ,
T15586 24220-24224 IN denotes onto
T15587 24225-24228 DT denotes the
T15588 24229-24232 NN denotes bar
T15589 24233-24237 IN denotes with
T15590 24238-24241 CD denotes two
T15591 24242-24250 NNS denotes forepaws
T15592 24251-24254 CC denotes and
T15593 24255-24258 CD denotes one
T15594 24272-24276 NNS denotes paws
T15595 24259-24261 CC denotes or
T15596 24262-24266 CC denotes both
T15597 24267-24271 NN denotes hind
T15598 24276-24277 : denotes ;
T15599 24278-24279 CD denotes 4
T15600 24281-24285 VBD denotes hung
T15601 24279-24281 , denotes ,
T15602 24286-24290 IN denotes onto
T15603 24291-24294 DT denotes the
T15604 24295-24298 NN denotes bar
T15605 24299-24303 IN denotes with
T15606 24304-24307 DT denotes all
T15607 24313-24317 NNS denotes paws
T15608 24308-24312 CD denotes four
T15609 24318-24322 IN denotes with
T15610 24323-24327 NN denotes tail
T15611 24328-24335 VBN denotes wrapped
T15612 24336-24342 IN denotes around
T15613 24343-24346 DT denotes the
T15614 24347-24350 NN denotes bar
T15615 24350-24351 : denotes ;
T15616 24352-24353 CD denotes 5
T15617 24353-24355 , denotes ,
T15618 24363-24365 IN denotes to
T15619 24366-24369 CD denotes one
T15620 24370-24372 IN denotes of
T15621 24373-24376 DT denotes the
T15622 24377-24385 NNS denotes supports
T15623 24385-24386 . denotes .
T15705 24388-24397 NN denotes Footprint
T15706 24398-24402 NN denotes test
T15707 24402-24531 sentence denotes Black ink was applied to the hind paws of each mouse and the mice were placed in a narrow alley (9 × 25 × 10 cm) on white paper.
T15708 24403-24408 JJ denotes Black
T15709 24409-24412 NN denotes ink
T15710 24417-24424 VBN denotes applied
T15711 24413-24416 VBD denotes was
T15712 24425-24427 IN denotes to
T15713 24428-24431 DT denotes the
T15714 24437-24441 NNS denotes paws
T15715 24432-24436 NN denotes hind
T15716 24442-24444 IN denotes of
T15717 24445-24449 DT denotes each
T15718 24450-24455 NN denotes mouse
T15719 24456-24459 CC denotes and
T15720 24460-24463 DT denotes the
T15721 24464-24468 NNS denotes mice
T15722 24474-24480 VBN denotes placed
T15723 24469-24473 VBD denotes were
T15724 24481-24483 IN denotes in
T15725 24484-24485 DT denotes a
T15726 24493-24498 NN denotes alley
T15727 24486-24492 JJ denotes narrow
T15728 24499-24500 -LRB- denotes (
T15729 24512-24514 NN denotes cm
T15730 24500-24501 CD denotes 9
T15731 24509-24511 CD denotes 10
T15732 24502-24503 SYM denotes ×
T15733 24504-24506 CD denotes 25
T15734 24507-24508 SYM denotes ×
T15735 24514-24515 -RRB- denotes )
T15736 24516-24518 IN denotes on
T15737 24519-24524 JJ denotes white
T15738 24525-24530 NN denotes paper
T15739 24530-24531 . denotes .
T15740 24531-24577 sentence denotes Stride length and step width were calculated.
T15741 24532-24538 NN denotes Stride
T15742 24539-24545 NN denotes length
T15743 24566-24576 VBN denotes calculated
T15744 24546-24549 CC denotes and
T15745 24550-24554 NN denotes step
T15746 24555-24560 NN denotes width
T15747 24561-24565 VBD denotes were
T15748 24576-24577 . denotes .
T15949 24579-24589 NNS denotes Statistics
T15950 24589-24628 sentence denotes Data are expressed as the means ± SEM.
T15951 24590-24594 NNS denotes Data
T15952 24599-24608 VBN denotes expressed
T15953 24595-24598 VBP denotes are
T15954 24609-24611 IN denotes as
T15955 24612-24615 DT denotes the
T15956 24624-24627 NN denotes SEM
T15957 24616-24621 NNS denotes means
T15958 24622-24623 SYM denotes ±
T15959 24627-24628 . denotes .
T15960 24628-24740 sentence denotes Statistical analysis was conducted using the software package SAS 8.1 (SAS Institute Japan Ltd., Tokyo, Japan).
T15961 24629-24640 JJ denotes Statistical
T15962 24641-24649 NN denotes analysis
T15963 24654-24663 VBN denotes conducted
T15964 24650-24653 VBD denotes was
T15965 24664-24669 VBG denotes using
T15966 24670-24673 DT denotes the
T15967 24683-24690 NN denotes package
T15968 24674-24682 NN denotes software
T15969 24691-24694 NN denotes SAS
T15970 24695-24698 CD denotes 8.1
T15971 24699-24700 -LRB- denotes (
T15972 24714-24719 NNP denotes Japan
T15973 24700-24703 NNP denotes SAS
T15974 24704-24713 NNP denotes Institute
T15975 24720-24724 NNP denotes Ltd.
T15976 24724-24726 , denotes ,
T15977 24726-24731 NNP denotes Tokyo
T15978 24731-24733 , denotes ,
T15979 24733-24738 NNP denotes Japan
T15980 24738-24739 -RRB- denotes )
T15981 24739-24740 . denotes .
T15982 24740-24956 sentence denotes Statistical significance was determined by analysis of variance (ANOVA) followed by the Dunnett-type multiple comparison test, and p values of less than 0.05 were considered to be significant in the water maze task.
T15983 24741-24752 JJ denotes Statistical
T15984 24753-24765 NN denotes significance
T15985 24770-24780 VBN denotes determined
T15986 24766-24769 VBD denotes was
T15987 24781-24783 IN denotes by
T15988 24784-24792 NN denotes analysis
T15989 24793-24795 IN denotes of
T15990 24796-24804 NN denotes variance
T15991 24805-24806 -LRB- denotes (
T15992 24806-24811 NN denotes ANOVA
T15993 24811-24812 -RRB- denotes )
T15994 24813-24821 VBN denotes followed
T15995 24822-24824 IN denotes by
T15996 24825-24828 DT denotes the
T15997 24862-24866 NN denotes test
T15998 24829-24836 NNP denotes Dunnett
T15999 24837-24841 NN denotes type
T16000 24836-24837 HYPH denotes -
T16001 24842-24850 JJ denotes multiple
T16002 24851-24861 NN denotes comparison
T16003 24866-24868 , denotes ,
T16004 24868-24871 CC denotes and
T16005 24872-24873 NN denotes p
T16006 24874-24880 NNS denotes values
T16007 24904-24914 VBN denotes considered
T16008 24881-24883 IN denotes of
T16009 24884-24888 JJR denotes less
T16010 24894-24898 CD denotes 0.05
T16011 24889-24893 IN denotes than
T16012 24899-24903 VBD denotes were
T16013 24915-24917 TO denotes to
T16014 24918-24920 VB denotes be
T16015 24921-24932 JJ denotes significant
T16016 24933-24935 IN denotes in
T16017 24936-24939 DT denotes the
T16018 24951-24955 NN denotes task
T16019 24940-24945 NN denotes water
T16020 24946-24950 NN denotes maze
T16021 24955-24956 . denotes .
T16022 24956-25127 sentence denotes Behavioural data in the rotating rod test were analysed by one- or two-way ANOVA with repeated measures, and p values of less than 0.05 were considered to be significant.
T16023 24957-24968 JJ denotes Behavioural
T16024 24969-24973 NNS denotes data
T16025 25004-25012 VBN denotes analysed
T16026 24974-24976 IN denotes in
T16027 24977-24980 DT denotes the
T16028 24994-24998 NN denotes test
T16029 24981-24989 VBG denotes rotating
T16030 24990-24993 NN denotes rod
T16031 24999-25003 VBD denotes were
T16032 25013-25015 IN denotes by
T16033 25016-25019 CD denotes one
T16034 25028-25031 NN denotes way
T16035 25019-25020 HYPH denotes -
T16036 25021-25023 CC denotes or
T16037 25024-25027 CD denotes two
T16038 25027-25028 HYPH denotes -
T16039 25032-25037 NN denotes ANOVA
T16040 25038-25042 IN denotes with
T16041 25043-25051 VBN denotes repeated
T16042 25052-25060 NNS denotes measures
T16043 25060-25062 , denotes ,
T16044 25062-25065 CC denotes and
T16045 25066-25067 NN denotes p
T16046 25068-25074 NNS denotes values
T16047 25098-25108 VBN denotes considered
T16048 25075-25077 IN denotes of
T16049 25078-25082 JJR denotes less
T16050 25088-25092 CD denotes 0.05
T16051 25083-25087 IN denotes than
T16052 25093-25097 VBD denotes were
T16053 25109-25111 TO denotes to
T16054 25112-25114 VB denotes be
T16055 25115-25126 JJ denotes significant
T16056 25126-25127 . denotes .
T16221 25129-25143 NN denotes Histopathology
T16222 25143-25364 sentence denotes Sections of tissues including the brain, spinal cord, heart, lung, liver, kidney, spleen and testis from mice (+/+, +/- and -/-; n = 7, 7 and 7, respectively) were fixed in 10% buffered formalin and embedded in paraffin.
T16223 25144-25152 NNS denotes Sections
T16224 25308-25313 VBN denotes fixed
T16225 25153-25155 IN denotes of
T16226 25156-25163 NNS denotes tissues
T16227 25164-25173 VBG denotes including
T16228 25174-25177 DT denotes the
T16229 25178-25183 NN denotes brain
T16230 25183-25185 , denotes ,
T16231 25185-25191 JJ denotes spinal
T16232 25192-25196 NN denotes cord
T16233 25196-25198 , denotes ,
T16234 25198-25203 NN denotes heart
T16235 25203-25205 , denotes ,
T16236 25205-25209 NN denotes lung
T16237 25209-25211 , denotes ,
T16238 25211-25216 NN denotes liver
T16239 25216-25218 , denotes ,
T16240 25218-25224 NN denotes kidney
T16241 25224-25226 , denotes ,
T16242 25226-25232 NN denotes spleen
T16243 25233-25236 CC denotes and
T16244 25237-25243 NN denotes testis
T16245 25244-25248 IN denotes from
T16246 25249-25253 NNS denotes mice
T16247 25254-25255 -LRB- denotes (
T16248 25257-25258 SYM denotes +
T16249 25255-25256 SYM denotes +
T16250 25256-25257 HYPH denotes /
T16251 25258-25260 , denotes ,
T16252 25260-25261 SYM denotes +
T16253 25262-25263 SYM denotes -
T16254 25261-25262 HYPH denotes /
T16255 25264-25267 CC denotes and
T16256 25268-25269 SYM denotes -
T16257 25270-25271 SYM denotes -
T16258 25269-25270 HYPH denotes /
T16259 25271-25272 : denotes ;
T16260 25273-25274 NN denotes n
T16261 25277-25278 CD denotes 7
T16262 25275-25276 SYM denotes =
T16263 25278-25280 , denotes ,
T16264 25280-25281 CD denotes 7
T16265 25282-25285 CC denotes and
T16266 25286-25287 CD denotes 7
T16267 25287-25289 , denotes ,
T16268 25289-25301 RB denotes respectively
T16269 25301-25302 -RRB- denotes )
T16270 25303-25307 VBD denotes were
T16271 25314-25316 IN denotes in
T16272 25317-25319 CD denotes 10
T16273 25319-25320 NN denotes %
T16274 25330-25338 NN denotes formalin
T16275 25321-25329 VBN denotes buffered
T16276 25339-25342 CC denotes and
T16277 25343-25351 VBN denotes embedded
T16278 25352-25354 IN denotes in
T16279 25355-25363 NN denotes paraffin
T16280 25363-25364 . denotes .
T16281 25364-25445 sentence denotes Each paraffin section of thick 4 μm was stained with hematoxylin and eosin (HE).
T16282 25365-25369 DT denotes Each
T16283 25379-25386 NN denotes section
T16284 25370-25378 NN denotes paraffin
T16285 25405-25412 VBN denotes stained
T16286 25387-25389 IN denotes of
T16287 25390-25395 JJ denotes thick
T16288 25398-25400 NN denotes μm
T16289 25396-25397 CD denotes 4
T16290 25401-25404 VBD denotes was
T16291 25413-25417 IN denotes with
T16292 25418-25429 NN denotes hematoxylin
T16293 25430-25433 CC denotes and
T16294 25434-25439 NN denotes eosin
T16295 25440-25441 -LRB- denotes (
T16296 25441-25443 NN denotes HE
T16297 25443-25444 -RRB- denotes )
T16298 25444-25445 . denotes .
T572 39-51 NN denotes coordination
T12588 19294-19302 NNP denotes Southern
T11271 17165-17167 IN denotes of
T11272 17168-17173 DT denotes these
T11273 17174-17179 NNS denotes ADAMs
T11274 17227-17234 VB denotes provide
T11275 17184-17189 RB denotes still
T11276 17190-17197 JJ denotes unclear
T11277 17197-17199 , denotes ,
T11278 17199-17206 JJ denotes further
T11279 17207-17221 NNS denotes investigations
T11280 17222-17226 MD denotes will
T11281 17235-17240 NNS denotes clues
T11282 17241-17243 IN denotes to
T11283 17244-17257 VBG denotes understanding
T11284 17258-17261 DT denotes the
T11285 17270-17276 NN denotes system
T11286 17262-17269 JJ denotes nervous
T11287 17277-17279 IN denotes of
T11288 17280-17286 JJR denotes higher
T11289 17287-17296 NNS denotes organisms
T11290 17296-17297 . denotes .
R3 T567 T565 prep in,Deficits
R4 T568 T569 amod spatial,learning
R5 T569 T567 pobj learning,in
R6 T570 T569 cc and,learning
R7 T571 T572 compound motor,coordination
R8 T573 T565 prep in,Deficits
R9 T574 T575 npadvmod ADAM11,deficient
R11 T576 T575 punct -,deficient
R12 T577 T573 pobj mice,in
R13 T582 T583 nsubj ADAM11,is
R14 T584 T585 det a,member
R15 T585 T583 attr member,is
R16 T586 T585 prep of,member
R17 T587 T588 det the,family
R18 T588 T586 pobj family,of
R19 T589 T588 compound ADAM,family
R20 T590 T588 compound gene,family
R21 T591 T583 cc and,is
R22 T592 T593 auxpass is,expressed
R24 T594 T593 advmod mainly,expressed
R25 T595 T593 prep in,expressed
R26 T596 T597 det the,system
R28 T598 T597 amod nervous,system
R29 T599 T583 punct .,is
R30 T601 T602 nsubjpass It,thought
R31 T603 T602 auxpass is,thought
R32 T604 T605 aux to,be
R33 T605 T602 xcomp be,thought
R34 T606 T607 det an,molecule
R36 T608 T607 compound adhesion,molecule
R37 T609 T602 punct ", ",thought
R38 T610 T611 mark since,has
R40 T612 T611 nsubj it,has
R41 T613 T614 det a,domain
R42 T614 T611 dobj domain,has
R43 T615 T616 npadvmod disintegrin,like
R44 T616 T614 amod like,domain
R45 T617 T616 punct -,like
R46 T618 T614 prep related,domain
R47 T619 T618 prep to,related
R48 T620 T621 nmod cell,cell
R50 T622 T621 punct -,cell
R51 T623 T619 pobj interactions,to
R52 T624 T621 cc or,cell
R53 T625 T626 nmod cell,matrix
R54 T626 T621 conj matrix,cell
R55 T627 T626 punct -,matrix
R56 T628 T602 punct .,thought
R57 T630 T631 aux To,elucidate
R58 T631 T632 advcl elucidate,generated
R59 T633 T634 det the,functions
R61 T635 T634 amod physiological,functions
R62 T636 T634 prep of,functions
R63 T637 T636 pobj ADAM11,of
R64 T638 T632 punct ", ",generated
R65 T639 T632 nsubj we,generated
R66 T640 T641 npadvmod ADAM11,deficient
R68 T642 T641 punct -,deficient
R69 T643 T632 dobj mice,generated
R70 T644 T632 prep by,generated
R71 T645 T644 pobj means,by
R72 T646 T645 prep of,means
R73 T647 T648 compound gene,targeting
R74 T648 T646 pobj targeting,of
R75 T649 T632 punct .,generated
R76 T653 T654 npadvmod ADAM11,deficient
R78 T655 T654 punct -,deficient
R79 T656 T657 nsubj mice,were
R80 T658 T657 advmod apparently,were
R81 T659 T657 acomp normal,were
R82 T660 T657 punct ", ",were
R83 T661 T657 cc and,were
R84 T662 T657 conj survived,were
R85 T663 T664 amod more,one
R87 T665 T664 quantmod than,one
R88 T666 T662 npadvmod year,survived
R89 T667 T662 prep with,survived
R90 T668 T669 det no,abnormalities
R91 T669 T667 pobj abnormalities,with
R92 T670 T669 amod major,abnormalities
R93 T671 T669 amod histological,abnormalities
R94 T672 T669 prep in,abnormalities
R95 T673 T674 det the,brain
R96 T674 T672 pobj brain,in
R97 T675 T674 cc or,brain
R98 T676 T677 amod spinal,cord
R99 T677 T674 conj cord,brain
R100 T678 T657 punct .,were
R101 T680 T681 mark Because,is
R103 T682 T681 nsubj ADAM11,is
R104 T684 T685 advmod highly,expressed
R105 T685 T681 acomp expressed,is
R106 T686 T681 prep in,is
R107 T687 T688 det the,hippocampus
R108 T688 T686 pobj hippocampus,in
R109 T689 T688 cc and,hippocampus
R110 T690 T688 conj cerebellum,hippocampus
R111 T691 T683 punct ", ",examined
R112 T692 T683 nsubj we,examined
R113 T693 T683 aux have,examined
R114 T694 T695 compound ADAM11,mice
R116 T696 T695 compound mutant,mice
R117 T697 T683 prep for,examined
R118 T698 T697 pobj learning,for
R119 T699 T683 advcl using,examined
R120 T700 T701 amod visual,tasks
R121 T701 T699 dobj tasks,using
R122 T702 T700 cc and,visual
R123 T703 T700 conj hidden,visual
R124 T704 T705 compound water,maze
R125 T705 T701 compound maze,tasks
R126 T706 T683 punct ", ",examined
R127 T707 T683 cc and,examined
R128 T708 T709 poss their,coordination
R130 T710 T709 amod motor,coordination
R131 T711 T709 advcl using,coordination
R132 T712 T713 det a,task
R133 T713 T711 dobj task,using
R134 T714 T715 amod rotating,rod
R135 T715 T713 compound rod,task
R136 T716 T683 punct .,examined
R137 T718 T719 poss Our,results
R138 T719 T720 nsubj results,showed
R139 T721 T722 mark that,are
R140 T722 T720 ccomp are,showed
R141 T723 T724 poss their,results
R142 T724 T722 nsubj results,are
R143 T725 T726 amod visual,maze
R144 T726 T728 compound maze,task
R145 T727 T726 compound water,maze
R146 T728 T724 compound task,results
R147 T729 T722 acomp normal,are
R148 T730 T720 punct ", ",showed
R149 T731 T720 cc but,showed
R150 T732 T733 det the,skills
R151 T733 T741 nsubj skills,are
R152 T734 T735 amod hidden,maze
R153 T735 T737 nmod maze,task
R154 T736 T735 nmod water,maze
R155 T737 T733 compound task,skills
R156 T738 T735 cc and,maze
R157 T739 T740 amod rotating,rod
R158 T740 T735 conj rod,maze
R159 T741 T720 conj are,showed
R160 T742 T741 acomp impaired,are
R161 T743 T741 prep in,are
R162 T744 T745 npadvmod ADAM11,deficient
R164 T746 T745 punct -,deficient
R165 T747 T743 pobj mice,in
R166 T748 T741 punct .,are
R167 T752 T753 poss Our,results
R168 T753 T754 nsubj results,indicate
R169 T755 T756 mark that,affect
R170 T756 T754 ccomp affect,indicate
R171 T757 T758 compound ADAM11,mutation
R172 T758 T756 nsubj mutation,affect
R173 T759 T756 aux does,affect
R174 T760 T756 neg not,affect
R175 T761 T762 compound cell,migration
R176 T762 T756 dobj migration,affect
R177 T763 T762 cc and,migration
R178 T764 T762 conj differentiation,migration
R179 T765 T756 prep during,affect
R180 T766 T765 pobj development,during
R181 T767 T756 punct ", ",affect
R182 T768 T756 cc but,affect
R183 T769 T756 conj affects,affect
R184 T770 T769 dobj learning,affects
R185 T771 T770 cc and,learning
R186 T772 T773 compound motor,coordination
R187 T773 T770 conj coordination,learning
R188 T774 T754 punct .,indicate
R189 T776 T777 advmod Thus,play
R190 T778 T777 punct ", ",play
R191 T779 T777 nsubj ADAM11,play
R192 T780 T777 aux might,play
R193 T781 T782 det an,role
R194 T782 T777 dobj role,play
R195 T783 T782 amod important,role
R196 T784 T782 nmod signalling,role
R197 T785 T784 cc or,signalling
R198 T786 T784 conj structural,signalling
R199 T787 T782 prep as,role
R200 T788 T789 det a,molecule
R201 T789 T787 pobj molecule,as
R202 T790 T791 compound cell,adhesion
R203 T791 T789 compound adhesion,molecule
R204 T792 T782 prep at,role
R205 T793 T794 det the,synapse
R206 T794 T792 pobj synapse,at
R207 T795 T777 punct ", ",play
R208 T796 T777 cc and,play
R209 T797 T798 aux may,participate
R211 T799 T798 advmod thus,participate
R212 T800 T798 prep in,participate
R213 T801 T802 amod synaptic,regulation
R214 T802 T800 pobj regulation,in
R215 T803 T802 acl underlying,regulation
R216 T804 T805 amod behavioural,changes
R217 T805 T803 dobj changes,underlying
R218 T806 T777 punct .,play
R219 T572 T569 conj coordination,learning
R222 T2208 T2209 det The,family
R223 T2209 T2217 nsubj family,comprises
R224 T2210 T2209 nmod ADAM,family
R225 T2211 T2210 punct (,ADAM
R226 T2212 T2213 det A,Disintegrin
R227 T2213 T2210 appos Disintegrin,ADAM
R228 T2214 T2213 cc And,Disintegrin
R229 T2215 T2213 conj Metalloprotease,Disintegrin
R230 T2216 T2209 punct ),family
R231 T2218 T2219 npadvmod membrane,spanning
R232 T2219 T2221 amod spanning,proteins
R233 T2220 T2219 punct -,spanning
R234 T2221 T2217 dobj proteins,comprises
R235 T2222 T2221 amod multi-domain,proteins
R236 T2223 T2221 acl containing,proteins
R237 T2224 T2225 det a,domain
R238 T2225 T2223 dobj domain,containing
R239 T2226 T2227 npadvmod metalloproteinase,like
R240 T2227 T2225 amod like,domain
R241 T2228 T2227 punct -,like
R242 T2229 T2225 cc and,domain
R243 T2230 T2231 det a,domain
R244 T2231 T2225 conj domain,domain
R245 T2232 T2233 npadvmod disintegrin,like
R246 T2233 T2231 amod like,domain
R247 T2234 T2233 punct -,like
R248 T2235 T2217 punct .,comprises
R249 T2237 T2238 advmod Approximately,half
R250 T2238 T2239 nsubj half,are
R251 T2240 T2238 prep of,half
R252 T2241 T2242 det the,ADAMs
R253 T2242 T2240 pobj ADAMs,of
R254 T2243 T2244 advmod catalytically,active
R255 T2244 T2245 amod active,metalloproteases
R256 T2245 T2239 attr metalloproteases,are
R257 T2246 T2247 dep that,shed
R258 T2247 T2245 relcl shed,metalloproteases
R259 T2248 T2249 det a,range
R260 T2249 T2247 dobj range,shed
R261 T2250 T2249 amod broad,range
R262 T2251 T2249 prep of,range
R263 T2252 T2251 pobj substrates,of
R264 T2253 T2252 punct ", ",substrates
R265 T2254 T2255 amod such,as
R266 T2255 T2252 prep as,substrates
R267 T2256 T2255 pobj cytokines,as
R268 T2257 T2256 punct ", ",cytokines
R269 T2258 T2259 compound growth,factors
R270 T2259 T2256 appos factors,cytokines
R271 T2260 T2256 punct ", ",cytokines
R272 T2261 T2256 appos receptors,cytokines
R273 T2262 T2256 punct ", ",cytokines
R274 T2263 T2264 compound adhesion,molecules
R275 T2264 T2256 appos molecules,cytokines
R276 T2265 T2266 punct [,2
R277 T2266 T2247 parataxis 2,shed
R278 T2267 T2266 nummod 1,2
R279 T2268 T2266 punct ",",2
R280 T2269 T2266 punct ],2
R281 T2270 T2239 punct .,are
R282 T2272 T2273 amod Recent,studies
R283 T2273 T2277 nsubj studies,disclosed
R284 T2274 T2275 compound gene,disruption
R285 T2275 T2273 compound disruption,studies
R286 T2276 T2275 punct -,disruption
R287 T2278 T2273 prep in,studies
R288 T2279 T2278 pobj mice,in
R289 T2280 T2277 aux have,disclosed
R290 T2281 T2282 det a,role
R291 T2282 T2277 dobj role,disclosed
R292 T2283 T2282 amod physiological,role
R293 T2284 T2282 prep of,role
R294 T2285 T2286 det each,ADAM
R295 T2286 T2284 pobj ADAM,of
R296 T2287 T2277 punct .,disclosed
R297 T2289 T2290 prep For,are
R298 T2291 T2289 pobj example,For
R299 T2292 T2290 punct ", ",are
R300 T2293 T2290 nsubj ADAM10,are
R301 T2294 T2293 punct ", ",ADAM10
R302 T2295 T2293 conj ADAM17,ADAM10
R303 T2296 T2295 cc and,ADAM17
R304 T2297 T2295 conj ADAM19,ADAM17
R305 T2298 T2290 acomp critical,are
R306 T2299 T2298 prep for,critical
R307 T2300 T2301 amod normal,development
R308 T2301 T2299 pobj development,for
R309 T2302 T2290 prep by,are
R310 T2303 T2302 pcomp providing,by
R311 T2304 T2305 compound growth,signals
R312 T2305 T2303 dobj signals,providing
R313 T2306 T2303 prep at,providing
R314 T2307 T2308 det the,times
R315 T2308 T2306 pobj times,at
R316 T2309 T2308 amod correct,times
R317 T2310 T2308 cc and,times
R318 T2311 T2308 conj places,times
R319 T2312 T2313 punct [,3
R320 T2313 T2303 parataxis 3,providing
R321 T2314 T2315 punct -,6
R322 T2315 T2313 prep 6,3
R323 T2316 T2313 punct ],3
R324 T2317 T2290 punct .,are
R325 T2319 T2320 prep In,are
R326 T2321 T2319 pobj contrast,In
R327 T2322 T2320 punct ", ",are
R328 T2323 T2324 det the,functions
R329 T2324 T2320 nsubj functions,are
R330 T2325 T2324 prep of,functions
R331 T2326 T2325 pobj ADAM8,of
R332 T2327 T2326 punct ", ",ADAM8
R333 T2328 T2326 conj ADAM9,ADAM8
R334 T2329 T2328 punct ", ",ADAM9
R335 T2330 T2328 conj ADAM12,ADAM9
R336 T2331 T2330 cc and,ADAM12
R337 T2332 T2330 conj ADAM15,ADAM12
R338 T2333 T2320 neg not,are
R339 T2334 T2320 acomp essential,are
R340 T2335 T2334 prep for,essential
R341 T2336 T2335 pobj embryogenesis,for
R342 T2337 T2320 punct ", ",are
R343 T2338 T2320 advcl suggesting,are
R344 T2339 T2340 det a,redundancy
R345 T2340 T2338 dobj redundancy,suggesting
R346 T2341 T2340 amod possible,redundancy
R347 T2342 T2340 amod functional,redundancy
R348 T2343 T2340 prep with,redundancy
R349 T2344 T2345 amod other,protease
R350 T2345 T2343 pobj protease,with
R351 T2346 T2347 punct [,7
R352 T2347 T2338 parataxis 7,suggesting
R353 T2348 T2349 punct -,10
R354 T2349 T2347 prep 10,7
R355 T2350 T2347 punct ],7
R356 T2351 T2320 punct .,are
R357 T2353 T2354 det The,half
R358 T2354 T2356 nsubjpass half,thought
R359 T2355 T2354 amod remaining,half
R360 T2357 T2354 punct ", ",half
R361 T2358 T2359 dep which,are
R362 T2359 T2354 relcl are,half
R363 T2360 T2361 amod non-protease,ADAMs
R364 T2361 T2359 attr ADAMs,are
R365 T2362 T2361 punct -,ADAMs
R366 T2363 T2356 punct ", ",thought
R367 T2364 T2356 auxpass are,thought
R368 T2365 T2366 aux to,be
R369 T2366 T2356 xcomp be,thought
R370 T2367 T2368 compound adhesion,molecules
R371 T2368 T2366 attr molecules,be
R372 T2369 T2356 punct .,thought
R373 T2371 T2372 amod More,ten
R374 T2372 T2374 nummod ten,ADAMs
R375 T2373 T2372 quantmod than,ten
R376 T2374 T2375 nsubjpass ADAMs,shown
R377 T2376 T2375 aux have,shown
R378 T2377 T2375 auxpass been,shown
R379 T2378 T2379 aux to,support
R380 T2379 T2375 xcomp support,shown
R381 T2380 T2381 npadvmod integrin,mediated
R382 T2381 T2383 amod mediated,adhesion
R383 T2382 T2381 punct -,mediated
R384 T2383 T2379 dobj adhesion,support
R385 T2384 T2383 compound cell,adhesion
R386 T2385 T2386 advmod in,vitro
R387 T2386 T2379 advmod vitro,support
R388 T2387 T2388 punct [,11
R389 T2388 T2375 parataxis 11,shown
R390 T2389 T2388 punct ],11
R391 T2390 T2375 punct .,shown
R392 T2392 T2393 advmod More,recently
R393 T2393 T2394 advmod recently,reported
R394 T2395 T2394 punct ", ",reported
R395 T2396 T2397 det the,finding
R396 T2397 T2394 nsubjpass finding,reported
R397 T2398 T2394 aux has,reported
R398 T2399 T2394 auxpass been,reported
R399 T2400 T2401 mark that,controlled
R400 T2401 T2394 ccomp controlled,reported
R401 T2402 T2403 npadvmod integrin,mediated
R402 T2403 T2405 amod mediated,migration
R403 T2404 T2403 punct -,mediated
R404 T2405 T2401 nsubjpass migration,controlled
R405 T2406 T2405 compound cell,migration
R406 T2407 T2405 prep of,migration
R407 T2408 T2409 compound tissue,culture
R408 T2409 T2410 compound culture,cells
R409 T2410 T2407 pobj cells,of
R410 T2411 T2401 aux can,controlled
R411 T2412 T2401 auxpass be,controlled
R412 T2413 T2401 agent by,controlled
R413 T2414 T2415 amod distinct,ADAMs
R414 T2415 T2413 pobj ADAMs,by
R415 T2416 T2417 punct [,12
R416 T2417 T2401 parataxis 12,controlled
R417 T2418 T2417 punct ],12
R418 T2419 T2394 punct .,reported
R419 T2421 T2422 prep In,shown
R420 T2423 T2424 compound C.,elegans
R421 T2424 T2421 pobj elegans,In
R422 T2425 T2422 punct ", ",shown
R423 T2426 T2427 nmod unc,gene
R424 T2427 T2422 nsubjpass gene,shown
R425 T2428 T2426 punct -,unc
R426 T2429 T2426 nummod 71,unc
R427 T2430 T2427 acl coding,gene
R428 T2431 T2432 det a,protein
R429 T2432 T2430 dobj protein,coding
R430 T2433 T2432 amod non-protease,protein
R431 T2434 T2432 punct -,protein
R432 T2435 T2432 compound ADAM,protein
R433 T2436 T2422 aux have,shown
R434 T2437 T2422 auxpass been,shown
R435 T2438 T2439 aux to,involved
R436 T2439 T2422 xcomp involved,shown
R437 T2440 T2439 auxpass be,involved
R438 T2441 T2439 prep in,involved
R439 T2442 T2443 compound cell,migration
R440 T2443 T2444 compound migration,events
R441 T2444 T2441 pobj events,in
R442 T2445 T2446 advmod in,vivo
R443 T2446 T2439 advmod vivo,involved
R444 T2447 T2448 punct [,13
R445 T2448 T2422 parataxis 13,shown
R446 T2449 T2448 punct ],13
R447 T2450 T2422 punct .,shown
R448 T2452 T2453 advmod However,are
R449 T2454 T2453 punct ", ",are
R450 T2455 T2456 det the,roles
R451 T2456 T2453 nsubj roles,are
R452 T2457 T2456 amod physiological,roles
R453 T2458 T2456 prep of,roles
R454 T2459 T2460 amod mammalian,ADAMs
R455 T2460 T2458 pobj ADAMs,of
R456 T2461 T2460 amod non-protease,ADAMs
R457 T2462 T2460 punct -,ADAMs
R458 T2463 T2464 advmod poorly,understood
R459 T2464 T2453 acomp understood,are
R460 T2465 T2466 advmod in,vivo
R461 T2466 T2453 advmod vivo,are
R462 T2467 T2453 punct .,are
R463 T2469 T2470 amod Genetic,deletion
R464 T2470 T2471 compound deletion,studies
R465 T2471 T2472 nsubj studies,shown
R466 T2473 T2471 prep in,studies
R467 T2474 T2473 pobj mice,in
R468 T2475 T2472 aux have,shown
R469 T2476 T2477 mark that,are
R470 T2477 T2472 ccomp are,shown
R471 T2478 T2479 preconj both,mutants
R472 T2479 T2477 nsubj mutants,are
R473 T2480 T2481 npadvmod Adam2,null
R474 T2481 T2479 amod null,mutants
R475 T2482 T2481 punct -,null
R476 T2483 T2481 cc and,null
R477 T2484 T2485 npadvmod Adam3,null
R478 T2485 T2481 conj null,null
R479 T2486 T2485 punct -,null
R480 T2487 T2479 amod male,mutants
R481 T2488 T2477 acomp infertile,are
R482 T2489 T2477 cc and,are
R483 T2490 T2491 poss their,spermatozoa
R484 T2491 T2492 nsubj spermatozoa,lack
R485 T2492 T2477 conj lack,are
R486 T2493 T2494 nmod egg,abilities
R487 T2494 T2492 dobj abilities,lack
R488 T2495 T2493 punct -,egg
R489 T2496 T2493 amod binding,egg
R490 T2497 T2498 punct [,14
R491 T2498 T2492 parataxis 14,lack
R492 T2499 T2500 punct -,16
R493 T2500 T2498 prep 16,14
R494 T2501 T2498 punct ],14
R495 T2502 T2472 punct .,shown
R496 T2504 T2505 det The,mechanism
R497 T2505 T2507 nsubj mechanism,is
R498 T2506 T2505 amod precise,mechanism
R499 T2508 T2507 prep under,is
R500 T2509 T2508 pobj investigation,under
R501 T2510 T2511 punct [,17
R502 T2511 T2507 parataxis 17,is
R503 T2512 T2511 punct ],17
R504 T2513 T2507 punct .,is
R505 T2515 T2516 nsubj We,reported
R506 T2517 T2516 aux have,reported
R507 T2518 T2519 det the,findings
R508 T2519 T2516 dobj findings,reported
R509 T2520 T2519 prep of,findings
R510 T2521 T2522 nmod ADAM11,genes
R512 T2523 T2521 punct ", ",ADAM11
R513 T2524 T2521 conj ADAM22,ADAM11
R514 T2525 T2524 cc and,ADAM22
R515 T2526 T2524 conj ADAM23,ADAM22
R516 T2527 T2522 cc and,genes
R517 T2528 T2529 poss their,expression
R518 T2529 T2522 conj expression,genes
R519 T2636 T2635 aux has,reported
R520 T2530 T2529 amod restricted,expression
R521 T2637 T2635 auxpass been,reported
R522 T2531 T2529 prep in,expression
R523 T2638 T2639 mark that,results
R524 T2532 T2533 det the,systems
R525 T2639 T2635 ccomp results,reported
R526 T2533 T2531 pobj systems,in
R527 T2640 T2641 det the,disruption
R528 T2534 T2533 amod human,systems
R529 T2535 T2534 cc and,human
R530 T2641 T2639 nsubj disruption,results
R531 T2536 T2534 conj murine,human
R532 T2537 T2533 amod nervous,systems
R533 T2538 T2539 punct [,19
R534 T2539 T2516 parataxis 19,reported
R535 T2540 T2539 nummod 18,19
R536 T2541 T2539 punct ",",19
R537 T2642 T2641 prep of,disruption
R538 T2542 T2539 punct ],19
R539 T2543 T2516 punct .,reported
R540 T2643 T2644 compound Adam23,gene
R541 T2545 T2546 det These,ADAMs
R542 T2644 T2642 pobj gene,of
R543 T2645 T2641 prep in,disruption
R544 T2546 T2547 nsubj ADAMs,lack
R545 T2646 T2647 det the,mouse
R546 T2548 T2549 det a,motif
R547 T2549 T2547 dobj motif,lack
R548 T2647 T2645 pobj mouse,in
R549 T2550 T2549 amod catalytic,motif
R550 T2551 T2549 amod critical,motif
R551 T2648 T2639 prep in,results
R552 T2552 T2551 prep for,critical
R553 T2553 T2554 det the,activity
R554 T2554 T2552 pobj activity,for
R555 T2649 T2650 amod premature,death
R556 T2555 T2554 compound metalloproteinase,activity
R557 T2556 T2547 punct ", ",lack
R558 T2557 T2547 advcl suggesting,lack
R559 T2650 T2648 pobj death,in
R560 T2558 T2559 mark that,are
R561 T2559 T2557 ccomp are,suggesting
R562 T2560 T2559 nsubj they,are
R563 T2651 T2650 acl associated,death
R564 T2561 T2559 neg not,are
R565 T2652 T2651 prep with,associated
R566 T2562 T2559 attr proteases,are
R567 T2563 T2547 punct .,lack
R568 T2565 T2566 nsubj We,assume
R569 T2653 T2652 pobj ataxia,with
R570 T2567 T2568 mark that,contribute
R571 T2654 T2653 cc and,ataxia
R572 T2568 T2566 ccomp contribute,assume
R573 T2569 T2570 det these,ADAMs
R574 T2570 T2568 nsubj ADAMs,contribute
R575 T2655 T2653 conj tremor,ataxia
R576 T2571 T2568 aux might,contribute
R577 T2572 T2568 prep to,contribute
R578 T2573 T2574 compound cell,migration
R579 T2574 T2572 pobj migration,to
R580 T2656 T2657 punct [,23
R581 T2575 T2574 punct ", ",migration
R582 T2576 T2574 conj differentiation,migration
R583 T2657 T2635 parataxis 23,reported
R584 T2577 T2576 cc and,differentiation
R585 T2578 T2576 conj survival,differentiation
R586 T2579 T2574 cc or,migration
R587 T2580 T2581 amod synaptic,regulation
R588 T2581 T2574 conj regulation,migration
R589 T2582 T2568 prep by,contribute
R590 T2583 T2582 pcomp binding,by
R591 T2658 T2657 punct ],23
R592 T2584 T2583 prep to,binding
R593 T2585 T2584 pobj integrins,to
R594 T2586 T2585 punct ", ",integrins
R595 T2659 T2635 punct .,reported
R596 T2587 T2588 compound cell,surface
R597 T2588 T2590 compound surface,proteins
R598 T2589 T2588 punct -,surface
R599 T2661 T2662 prep Is,observed
R600 T2590 T2585 conj proteins,integrins
R601 T2591 T2590 cc or,proteins
R602 T2592 T2593 amod intracellular,molecules
R603 T2593 T2590 conj molecules,proteins
R604 T2663 T2661 pobj spite,Is
R605 T2594 T2593 compound signalling,molecules
R606 T2595 T2596 punct [,21
R607 T2596 T2568 parataxis 21,contribute
R608 T2597 T2596 nummod 20,21
R609 T2598 T2596 punct ",",21
R610 T2664 T2663 prep of,spite
R611 T2599 T2596 punct ],21
R612 T2600 T2566 punct .,assume
R613 T2665 T2666 amod such,phenotypes
R614 T2602 T2603 nsubj We,reported
R615 T2666 T2664 pobj phenotypes,of
R616 T2604 T2603 aux have,reported
R617 T2667 T2666 amod extreme,phenotypes
R618 T2605 T2606 amod severe,ataxia
R619 T2606 T2603 dobj ataxia,reported
R620 T2607 T2606 punct ", ",ataxia
R621 T2668 T2662 punct ", ",observed
R622 T2608 T2606 conj seizures,ataxia
R623 T2609 T2608 punct ", ",seizures
R624 T2610 T2608 cc and,seizures
R625 T2669 T2670 det no,defects
R626 T2611 T2608 conj death,seizures
R627 T2612 T2611 prep before,death
R628 T2613 T2612 pobj weaning,before
R629 T2670 T2662 nsubjpass defects,observed
R630 T2614 T2606 punct ", ",ataxia
R631 T2615 T2606 acl accompanied,ataxia
R632 T2671 T2670 amod histological,defects
R633 T2616 T2615 prep with,accompanied
R634 T2617 T2616 pobj hypomyelination,with
R635 T2618 T2617 prep of,hypomyelination
R636 T2672 T2670 prep in,defects
R637 T2619 T2620 det the,system
R638 T2673 T2674 det the,brain
R639 T2620 T2618 pobj system,of
R640 T2621 T2620 amod peripheral,system
R641 T2622 T2620 amod nervous,system
R642 T2623 T2603 prep in,reported
R643 T2624 T2625 npadvmod Adam22,null
R644 T2674 T2672 pobj brain,in
R645 T2625 T2627 amod null,mice
R646 T2626 T2625 punct -,null
R647 T2627 T2623 pobj mice,in
R648 T2675 T2662 aux has,observed
R649 T2628 T2627 compound mutant,mice
R650 T2629 T2630 punct [,22
R651 T2630 T2603 parataxis 22,reported
R652 T2676 T2662 auxpass been,observed
R653 T2631 T2630 punct ],22
R654 T2632 T2603 punct .,reported
R655 T2677 T2662 prep in,observed
R656 T2634 T2635 nsubjpass It,reported
R657 T2678 T2679 preconj either,mice
R658 T2679 T2677 pobj mice,in
R659 T2680 T2681 npadvmod Adam22,null
R660 T2681 T2679 amod null,mice
R661 T2682 T2681 punct -,null
R662 T2683 T2681 cc nor,null
R663 T2742 T2743 punct [,24
R664 T2743 T2715 parataxis 24,reported
R665 T2684 T2685 npadvmod Adam23,null
R666 T2744 T2743 punct ],24
R667 T2745 T2715 punct ;,reported
R668 T2685 T2681 conj null,null
R669 T2746 T2715 cc and,reported
R670 T2747 T2748 nsubjpass it,reported
R671 T2748 T2715 conj reported,reported
R672 T2749 T2748 aux has,reported
R673 T2686 T2685 punct -,null
R674 T2750 T2748 auxpass been,reported
R675 T2751 T2748 prep in,reported
R676 T2687 T2662 punct .,observed
R677 T2752 T2751 pobj analyses,in
R678 T2753 T2752 acl using,analyses
R679 T2689 T2690 nsubj ADAM11,is
R680 T2754 T2755 nmod Northern,blot
R681 T2755 T2756 nmod blot,methods
R682 T2756 T2753 dobj methods,using
R683 T2757 T2755 cc and,blot
R684 T2691 T2692 det the,paralog
R685 T2758 T2759 advmod in,situ
R686 T2759 T2755 conj situ,blot
R687 T2760 T2756 compound hybridisation,methods
R688 T2761 T2762 mark that,expressed
R689 T2692 T2690 attr paralog,is
R690 T2762 T2748 ccomp expressed,reported
R691 T2763 T2764 det the,gene
R692 T2764 T2762 nsubjpass gene,expressed
R693 T2765 T2764 amod murine,gene
R694 T2766 T2764 compound Adam11,gene
R695 T2767 T2762 auxpass is,expressed
R696 T2693 T2692 amod closest,paralog
R697 T2768 T2762 prep in,expressed
R698 T2769 T2770 preconj both,system
R699 T2770 T2768 pobj system,in
R700 T2694 T2692 prep of,paralog
R701 T2771 T2770 det the,system
R702 T2772 T2770 amod developing,system
R703 T2773 T2772 cc and,developing
R704 T2695 T2694 pobj ADAM22,of
R705 T2774 T2772 conj adult,developing
R706 T2775 T2770 amod nervous,system
R707 T2696 T2695 cc and,ADAM22
R708 T2776 T2777 punct [,25
R709 T2777 T2748 parataxis 25,reported
R710 T2778 T2777 nummod 19,25
R711 T2697 T2695 conj ADAM23,ADAM22
R712 T2779 T2777 punct ",",25
R713 T2780 T2777 punct ],25
R714 T2781 T2748 punct .,reported
R715 T2698 T2690 punct ", ",is
R716 T2783 T2784 det These,findings
R717 T2784 T2785 nsubj findings,led
R718 T2699 T2690 cc and,is
R719 T2786 T2785 dobj us,led
R720 T2700 T2701 poss its,orthologs
R721 T2787 T2788 aux to,hypothesise
R722 T2788 T2785 xcomp hypothesise,led
R723 T2789 T2790 mark that,is
R724 T2790 T2788 ccomp is,hypothesise
R725 T2701 T2702 nsubjpass orthologs,found
R726 T2791 T2790 nsubj ADAM11,is
R727 T2792 T2793 det an,binder
R728 T2702 T2690 conj found,is
R729 T2703 T2702 aux have,found
R730 T2704 T2702 auxpass been,found
R731 T2793 T2790 attr binder,is
R732 T2705 T2702 prep in,found
R733 T2794 T2793 compound integrin,binder
R734 T2795 T2796 dep that,plays
R735 T2796 T2793 relcl plays,binder
R736 T2797 T2798 det an,role
R737 T2706 T2705 pobj vertebrates,in
R738 T2798 T2796 dobj role,plays
R739 T2799 T2798 amod important,role
R740 T2800 T2796 prep in,plays
R741 T2707 T2705 punct ", ",in
R742 T2801 T2802 det the,system
R743 T2708 T2705 cc but,in
R744 T2802 T2800 pobj system,in
R745 T2803 T2802 amod nervous,system
R746 T2804 T2796 punct ", ",plays
R747 T2805 T2806 mark as,do
R748 T2806 T2796 advcl do,plays
R749 T2807 T2806 nsubj ADAM22,do
R750 T2709 T2708 neg not,but
R751 T2808 T2807 cc and,ADAM22
R752 T2809 T2807 conj ADAM23,ADAM22
R753 T2810 T2785 punct .,led
R754 T2710 T2705 conj in,in
R755 T2812 T2813 aux To,determine
R756 T2813 T2814 advcl determine,generated
R757 T2711 T2710 pobj invertebrates,in
R758 T2815 T2816 det the,functions
R759 T2816 T2813 dobj functions,determine
R760 T2712 T2702 punct .,found
R761 T2817 T2816 amod physiological,functions
R762 T2818 T2816 prep of,functions
R763 T2714 T2715 nsubjpass It,reported
R764 T2819 T2818 pobj ADAM11,of
R765 T2820 T2814 punct ", ",generated
R766 T2821 T2814 nsubj we,generated
R767 T2822 T2814 cc and,generated
R768 T2823 T2814 conj analysed,generated
R769 T2716 T2715 aux has,reported
R770 T2824 T2825 nmod Adam11,mice
R771 T2825 T2823 dobj mice,analysed
R772 T2826 T2827 npadvmod gene,targeted
R773 T2717 T2715 auxpass been,reported
R774 T2827 T2825 amod targeted,mice
R775 T2828 T2827 punct -,targeted
R776 T2829 T2814 punct .,generated
R777 T2718 T2719 mark that,has
R778 T2719 T2715 ccomp has,reported
R779 T2720 T2721 det the,ortholog
R780 T2721 T2719 nsubj ortholog,has
R781 T2722 T2721 compound Xenopus,ortholog
R782 T2723 T2721 compound ADAM11,ortholog
R783 T2724 T2721 punct ", ",ortholog
R784 T2725 T2721 appos xMDC11a,ortholog
R785 T2726 T2719 punct ", ",has
R786 T2727 T2728 det an,pattern
R787 T2728 T2719 dobj pattern,has
R788 T2729 T2728 compound expression,pattern
R789 T2730 T2728 acl associated,pattern
R790 T2731 T2730 prep with,associated
R791 T2732 T2733 amod neural,development
R792 T2733 T2731 pobj development,with
R793 T2734 T2728 punct ", ",pattern
R794 T2735 T2728 prep with,pattern
R795 T2736 T2737 det a,role
R796 T2737 T2735 pobj role,with
R797 T2738 T2737 amod proposed,role
R798 T2739 T2737 prep in,role
R799 T2740 T2741 compound cell,migration
R800 T2741 T2739 pobj migration,in
R801 T3215 T3214 prep of,Generation
R802 T3216 T3217 npadvmod ADAM11,deficient
R803 T3217 T3219 amod deficient,mice
R804 T3218 T3217 punct -,deficient
R805 T3219 T3215 pobj mice,of
R806 T3221 T3222 nsubjpass Mice,generated
R807 T3223 T3221 acl carrying,Mice
R808 T3224 T3225 det a,mutation
R809 T3225 T3223 dobj mutation,carrying
R810 T3226 T3225 amod targeted,mutation
R811 T3227 T3223 prep in,carrying
R812 T3228 T3229 poss their,gene
R813 T3229 T3227 pobj gene,in
R814 T3230 T3229 compound Adam11,gene
R815 T3231 T3222 auxpass were,generated
R816 T3232 T3222 prep by,generated
R817 T3233 T3234 amod homologous,recombination
R818 T3234 T3232 pobj recombination,by
R819 T3235 T3236 punct (,1A
R820 T3236 T3222 parataxis 1A,generated
R821 T3237 T3236 compound Fig.,1A
R822 T3238 T3236 punct ),1A
R823 T3239 T3222 punct .,generated
R824 T3241 T3242 amod Correct,events
R825 T3242 T3244 nsubjpass events,confirmed
R826 T3243 T3242 compound targeting,events
R827 T3245 T3244 auxpass were,confirmed
R828 T3246 T3244 agent by,confirmed
R829 T3247 T3248 compound Southern,blot
R830 T3248 T3249 compound blot,analysis
R831 T3249 T3246 pobj analysis,by
R832 T3250 T3251 punct (,1B
R833 T3251 T3244 parataxis 1B,confirmed
R834 T3252 T3251 compound Fig.,1B
R835 T3253 T3251 punct ),1B
R836 T3254 T3244 punct .,confirmed
R837 T3256 T3257 prep As,synthesised
R838 T3258 T3259 det a,result
R839 T3259 T3256 pobj result,As
R840 T3260 T3259 prep of,result
R841 T3261 T3262 det this,procedure
R842 T3262 T3260 pobj procedure,of
R843 T3263 T3257 punct ", ",synthesised
R844 T3264 T3265 mark since,introduced
R846 T3266 T3267 det a,codon
R847 T3267 T3265 nsubjpass codon,introduced
R848 T3268 T3267 compound termination,codon
R849 T3269 T3265 auxpass was,introduced
R850 T3270 T3265 prep in,introduced
R851 T3271 T3270 pobj exon,in
R852 T3272 T3271 nummod 5,exon
R853 T3273 T3265 prep in,introduced
R854 T3274 T3275 det the,domain
R855 T3275 T3273 pobj domain,in
R856 T3276 T3275 amod pro-protein,domain
R857 T3277 T3257 punct ", ",synthesised
R858 T3278 T3279 advmod only,form
R859 T3279 T3257 nsubjpass form,synthesised
R860 T3280 T3279 det the,form
R861 T3281 T3279 amod truncated,form
R862 T3282 T3279 prep of,form
R863 T3283 T3284 det the,protein
R864 T3284 T3282 pobj protein,of
R865 T3285 T3284 compound ADAM11,protein
R866 T3286 T3257 aux would,synthesised
R867 T3287 T3257 auxpass be,synthesised
R868 T3288 T3257 prep from,synthesised
R869 T3289 T3290 det this,allele
R870 T3290 T3288 pobj allele,from
R871 T3291 T3290 amod targeted,allele
R872 T3292 T3257 punct .,synthesised
R873 T3294 T3295 mark Because,removed
R875 T3296 T3297 amod pro-protein,domains
R876 T3297 T3295 nsubjpass domains,removed
R877 T3298 T3295 auxpass are,removed
R878 T3299 T3295 advmod always,removed
R879 T3301 T3295 prep in,removed
R880 T3302 T3303 amod mature,proteins
R881 T3303 T3301 pobj proteins,in
R882 T3304 T3303 amod functional,proteins
R883 T3305 T3303 compound ADAM,proteins
R884 T3306 T3303 punct -,proteins
R885 T3307 T3295 agent by,removed
R886 T3308 T3309 npadvmod furin,like
R887 T3309 T3311 amod like,proteases
R888 T3310 T3309 punct -,like
R889 T3311 T3307 pobj proteases,by
R890 T3312 T3295 cc and,removed
R891 T3313 T3314 auxpass are,thought
R892 T3314 T3295 conj thought,removed
R893 T3315 T3314 advmod thus,thought
R894 T3316 T3317 aux to,be
R895 T3317 T3314 xcomp be,thought
R896 T3318 T3317 acomp non-functional,be
R897 T3319 T3300 punct ", ",concluded
R898 T3320 T3300 nsubj we,concluded
R899 T3321 T3322 mark that,have
R900 T3322 T3300 ccomp have,concluded
R901 T3323 T3324 det this,form
R902 T3324 T3322 nsubj form,have
R903 T3325 T3324 amod truncated,form
R904 T3326 T3324 prep of,form
R905 T3327 T3328 compound ADAM11,protein
R906 T3328 T3326 pobj protein,of
R907 T3329 T3322 aux would,have
R908 T3330 T3331 det no,function
R909 T3331 T3322 dobj function,have
R910 T3332 T3333 punct [,26
R911 T3333 T3322 parataxis 26,have
R912 T3334 T3333 punct ],26
R913 T3335 T3300 punct .,concluded
R914 T3337 T3338 nsubjpass Absence,confirmed
R915 T3339 T3337 prep of,Absence
R916 T3340 T3341 amod mature,protein
R917 T3341 T3339 pobj protein,of
R918 T3342 T3341 compound ADAM11,protein
R919 T3343 T3337 prep in,Absence
R920 T3344 T3345 amod homozygous,mutants
R921 T3345 T3343 pobj mutants,in
R922 T3346 T3338 auxpass was,confirmed
R923 T3347 T3338 prep by,confirmed
R924 T3348 T3349 compound Western,blot
R925 T3349 T3350 compound blot,analysis
R926 T3350 T3347 pobj analysis,by
R927 T3351 T3350 acl using,analysis
R928 T3352 T3353 det a,antibody
R929 T3353 T3351 dobj antibody,using
R930 T3354 T3353 amod specific,antibody
R931 T3355 T3356 dep that,recognises
R932 T3356 T3353 relcl recognises,antibody
R933 T3357 T3358 det the,protein
R934 T3358 T3356 dobj protein,recognises
R935 T3359 T3358 compound ADAM11,protein
R936 T3360 T3361 punct (,1C
R937 T3361 T3338 parataxis 1C,confirmed
R938 T3362 T3361 compound Fig.,1C
R939 T3363 T3361 punct ),1C
R940 T3364 T3338 punct .,confirmed
R941 T3366 T3367 nsubj Analysis,showed
R942 T3368 T3366 prep by,Analysis
R943 T3369 T3370 compound Western,blot
R944 T3370 T3368 pobj blot,by
R945 T3371 T3372 mark that,produced
R946 T3372 T3367 ccomp produced,showed
R947 T3373 T3374 amod heterozygous,mutants
R948 T3374 T3372 nsubj mutants,produced
R949 T3375 T3376 advmod approximately,half
R950 T3376 T3372 dobj half,produced
R951 T3377 T3376 prep of,half
R952 T3378 T3379 det the,levels
R953 T3379 T3377 pobj levels,of
R954 T3380 T3381 amod wild,type
R955 T3381 T3379 compound type,levels
R956 T3382 T3381 punct -,type
R957 T3383 T3379 prep of,levels
R958 T3384 T3385 compound ADAM11,protein
R959 T3385 T3383 pobj protein,of
R960 T3386 T3367 punct .,showed
R961 T3987 T3988 npadvmod ADAM11,deficient
R962 T3988 T3990 amod deficient,mice
R963 T3989 T3988 punct -,deficient
R964 T3990 T3991 nsubj mice,are
R965 T3992 T3991 acomp viable,are
R966 T3993 T3991 cc and,are
R967 T3994 T3991 conj appear,are
R968 T3995 T3994 oprd normal,appear
R969 T3997 T3998 nsubj Mating,yielded
R970 T3999 T3997 prep of,Mating
R971 T4000 T3999 pobj mice,of
R972 T4001 T4000 amod heterozygous,mice
R973 T4002 T4001 prep for,heterozygous
R974 T4003 T4004 det the,mutation
R975 T4004 T4002 pobj mutation,for
R976 T4005 T4004 compound ADAM11,mutation
R977 T4006 T4007 det a,distribution
R978 T4007 T3998 dobj distribution,yielded
R979 T4008 T4009 amod near,Mendelian
R980 T4009 T4007 amod Mendelian,distribution
R981 T4010 T4009 punct -,Mendelian
R982 T4011 T4007 prep of,distribution
R983 T4012 T4011 pobj genotypes,of
R984 T4013 T3998 prep in,yielded
R985 T4014 T4015 det the,offspring
R986 T4015 T4013 pobj offspring,in
R987 T4016 T3998 cc and,yielded
R988 T4017 T4018 det the,ratio
R989 T4018 T4019 nsubj ratio,was
R991 T4020 T4018 prep of,ratio
R992 T4021 T4020 pobj females,of
R993 T4022 T4021 cc and,females
R994 T4023 T4021 conj males,females
R995 T4024 T4025 det the,same
R996 T4025 T4019 attr same,was
R997 T4026 T4019 prep in,was
R998 T4027 T4028 det all,groups
R999 T4028 T4026 pobj groups,in
R1000 T4029 T4030 punct (,shown
R1001 T4030 T4019 parataxis shown,was
R1002 T4031 T4030 nsubj data,shown
R1003 T4032 T4030 neg not,shown
R1004 T4033 T4030 punct ),shown
R1005 T4034 T4019 punct .,was
R1006 T4036 T4037 prep For,used
R1007 T4038 T4039 det the,experiments
R1008 T4039 T4036 pobj experiments,For
R1009 T4040 T4039 amod present,experiments
R1010 T4041 T4037 punct ", ",used
R1011 T4042 T4043 npadvmod ADAM11,deficient
R1012 T4043 T4045 amod deficient,mice
R1013 T4044 T4043 punct -,deficient
R1014 T4045 T4037 nsubjpass mice,used
R1015 T4046 T4045 amod male,mice
R1016 T4047 T4048 punct (,generations
R1017 T4048 T4045 parataxis generations,mice
R1018 T4049 T4048 amod backcrossed,generations
R1019 T4050 T4048 prep into,generations
R1020 T4051 T4052 compound C57BL,6NCrj
R1021 T4052 T4050 pobj 6NCrj,into
R1022 T4053 T4052 punct /,6NCrj
R1023 T4054 T4048 punct ", ",generations
R1024 T4055 T4056 nsubj n,14
R1025 T4056 T4048 ccomp 14,generations
R1026 T4057 T4056 punct =,14
R1027 T4058 T4048 punct ),generations
R1028 T4059 T4037 auxpass were,used
R1029 T4060 T4037 prep in,used
R1030 T4061 T4062 det all,analyses
R1031 T4062 T4060 pobj analyses,in
R1032 T4063 T4062 amod behavioural,analyses
R1033 T4064 T4062 cc and,analyses
R1034 T4065 T4066 amod anatomical,histological
R1035 T4066 T4068 amod histological,studies
R1036 T4067 T4066 punct -,histological
R1037 T4068 T4062 conj studies,analyses
R1038 T4069 T4037 punct .,used
R1039 T4071 T4072 amod Homozygous,mice
R1040 T4072 T4076 nsubj mice,were
R1041 T4073 T4074 npadvmod ADAM11,deficient
R1042 T4074 T4072 amod deficient,mice
R1043 T4075 T4074 punct -,deficient
R1044 T4077 T4076 acomp viable,were
R1045 T4078 T4076 cc and,were
R1046 T4079 T4076 conj appeared,were
R1047 T4080 T4079 oprd normal,appeared
R1048 T4081 T4076 punct ", ",were
R1049 T4082 T4076 advcl indicating,were
R1050 T4083 T4084 mark that,is
R1051 T4084 T4082 ccomp is,indicating
R1052 T4085 T4086 det the,gene
R1053 T4086 T4084 nsubj gene,is
R1054 T4087 T4086 compound Adam11,gene
R1055 T4088 T4084 neg not,is
R1056 T4089 T4084 acomp essential,is
R1057 T4090 T4089 prep to,essential
R1058 T4091 T4090 pobj development,to
R1059 T4092 T4091 cc and,development
R1060 T4093 T4091 conj survival,development
R1061 T4094 T4076 punct .,were
R1062 T4096 T4097 det The,gain
R1063 T4097 T4098 nsubj gain,was
R1064 T4099 T4097 prep in,gain
R1065 T4100 T4101 compound body,weight
R1066 T4101 T4099 pobj weight,in
R1067 T4102 T4097 prep of,gain
R1068 T4103 T4104 punct (,mice
R1070 T4105 T4106 punct -,-
R1071 T4106 T4104 punct -,mice
R1072 T4107 T4106 punct /,-
R1073 T4108 T4104 punct ),mice
R1074 T4109 T4098 acomp comparable,was
R1075 T4110 T4109 prep to,comparable
R1076 T4111 T4110 pobj that,to
R1077 T4112 T4111 prep of,that
R1078 T4113 T4114 punct (,mice
R1079 T4114 T4112 pobj mice,of
R1080 T4115 T4116 punct +,+
R1081 T4116 T4114 punct +,mice
R1082 T4117 T4116 punct /,+
R1083 T4118 T4116 punct ),+
R1084 T4119 T4116 cc and,+
R1085 T4120 T4121 punct (,-
R1086 T4121 T4116 conj -,+
R1087 T4122 T4121 punct +,-
R1088 T4123 T4121 punct /,-
R1089 T4124 T4114 punct ),mice
R1090 T4125 T4126 advmod at,least
R1091 T4126 T4127 advmod least,until
R1092 T4127 T4098 prep until,was
R1093 T4128 T4129 nummod 24,weeks
R1094 T4129 T4127 pobj weeks,until
R1095 T4130 T4129 prep of,weeks
R1096 T4131 T4130 pobj age,of
R1097 T4132 T4133 punct (,shown
R1098 T4133 T4098 parataxis shown,was
R1099 T4134 T4133 nsubj data,shown
R1100 T4135 T4133 neg not,shown
R1101 T4136 T4133 punct ),shown
R1102 T4137 T4098 punct .,was
R1103 T4139 T4140 expl There,was
R1104 T4141 T4142 det no,difference
R1105 T4142 T4140 attr difference,was
R1106 T4143 T4142 amod significant,difference
R1107 T4144 T4142 prep in,difference
R1108 T4145 T4146 compound locomotor,activity
R1109 T4146 T4144 pobj activity,in
R1110 T4147 T4142 prep among,difference
R1111 T4148 T4149 punct (,genotypes
R1112 T4149 T4147 pobj genotypes,among
R1113 T4150 T4151 punct +,+
R1114 T4151 T4149 punct +,genotypes
R1115 T4152 T4151 punct /,+
R1116 T4153 T4151 punct ),+
R1117 T4154 T4151 punct ", ",+
R1118 T4155 T4156 punct (,-
R1119 T4156 T4151 conj -,+
R1120 T4157 T4156 punct +,-
R1121 T4158 T4156 punct /,-
R1122 T4159 T4156 punct ),-
R1123 T4160 T4156 cc and,-
R1124 T4161 T4162 punct (,-
R1125 T4162 T4156 conj -,-
R1126 T4163 T4162 punct -,-
R1127 T4164 T4162 punct /,-
R1128 T4165 T4149 punct ),genotypes
R1129 T4166 T4167 punct (,shown
R1130 T4167 T4140 parataxis shown,was
R1131 T4168 T4167 nsubj data,shown
R1132 T4169 T4167 neg not,shown
R1133 T4170 T4167 punct ),shown
R1134 T4171 T4140 punct .,was
R1135 T4173 T4174 det No,change
R1137 T4175 T4174 amod apparent,change
R1138 T4176 T4177 amod anatomical,histological
R1139 T4177 T4174 amod histological,change
R1140 T4178 T4177 punct -,histological
R1141 T4180 T4179 auxpass was,observed
R1142 T4181 T4179 prep in,observed
R1143 T4182 T4183 det the,cord
R1144 T4183 T4181 pobj cord,in
R1145 T4184 T4183 amod spinal,cord
R1146 T4185 T4183 punct ", ",cord
R1147 T4186 T4183 conj heart,cord
R1148 T4187 T4186 punct ", ",heart
R1149 T4188 T4186 conj lung,heart
R1150 T4189 T4188 punct ", ",lung
R1151 T4190 T4188 conj liver,lung
R1152 T4191 T4190 punct ", ",liver
R1153 T4192 T4190 conj kidney,liver
R1154 T4193 T4192 punct ", ",kidney
R1155 T4194 T4192 conj spleen,kidney
R1156 T4195 T4194 punct ", ",spleen
R1157 T4196 T4194 conj testis,spleen
R1158 T4197 T4196 cc or,testis
R1159 T4198 T4196 conj ovary,testis
R1160 T4199 T4200 punct (,shown
R1161 T4200 T4179 parataxis shown,observed
R1162 T4201 T4200 nsubj data,shown
R1163 T4202 T4200 neg not,shown
R1164 T4203 T4200 punct ),shown
R1165 T4204 T4179 punct .,observed
R1166 T4206 T4207 det The,brain
R1167 T4207 T4208 nsubj brain,appeared
R1168 T4209 T4207 prep of,brain
R1169 T4210 T4211 punct (,mice
R1171 T4212 T4213 punct -,-
R1172 T4213 T4211 punct -,mice
R1173 T4214 T4213 punct /,-
R1174 T4215 T4211 punct ),mice
R1175 T4216 T4207 punct ", ",brain
R1176 T4217 T4207 prep including,brain
R1177 T4218 T4219 det the,hippocampus
R1178 T4219 T4217 pobj hippocampus,including
R1179 T4220 T4221 punct (,1D
R1180 T4221 T4219 parataxis 1D,hippocampus
R1181 T4222 T4221 compound Fig.,1D
R1182 T4223 T4221 punct ),1D
R1183 T4224 T4219 cc and,hippocampus
R1184 T4225 T4219 conj cerebellum,hippocampus
R1185 T4226 T4227 punct (,1E
R1186 T4227 T4225 parataxis 1E,cerebellum
R1187 T4228 T4227 compound Fig.,1E
R1188 T4229 T4227 punct ),1E
R1189 T4230 T4208 oprd normal,appeared
R1190 T4231 T4208 prep after,appeared
R1191 T4232 T4233 compound HE,staining
R1192 T4233 T4231 pobj staining,after
R1193 T4234 T4235 advmod when,compared
R1194 T4235 T4208 advcl compared,appeared
R1195 T4236 T4237 punct (,mice
R1196 T4237 T4235 nsubjpass mice,compared
R1197 T4238 T4239 punct +,+
R1198 T4239 T4237 punct +,mice
R1199 T4240 T4239 punct /,+
R1200 T4241 T4239 punct ),+
R1201 T4242 T4239 punct ", ",+
R1202 T4243 T4244 punct (,-
R1203 T4244 T4239 conj -,+
R1204 T4245 T4244 punct +,-
R1205 T4246 T4244 punct /,-
R1206 T4247 T4244 punct ),-
R1207 T4248 T4244 cc and,-
R1208 T4249 T4250 punct (,-
R1209 T4250 T4244 conj -,-
R1210 T4251 T4250 punct -,-
R1211 T4252 T4250 punct /,-
R1212 T4253 T4237 punct ),mice
R1213 T4254 T4235 auxpass were,compared
R1214 T4255 T4208 punct .,appeared
R1215 T4257 T4258 mark Since,expressed
R1216 T4258 T4262 advcl expressed,applied
R1217 T4259 T4258 nsubjpass Adam11,expressed
R1218 T4260 T4258 auxpass is,expressed
R1219 T4261 T4258 advmod predominantly,expressed
R1220 T4263 T4258 prep in,expressed
R1221 T4264 T4265 det the,hippocampus
R1222 T4265 T4263 pobj hippocampus,in
R1223 T4266 T4265 cc and,hippocampus
R1224 T4267 T4265 conj cerebellum,hippocampus
R1225 T4268 T4262 punct ", ",applied
R1226 T4269 T4262 nsubj we,applied
R1227 T4270 T4271 npadvmod hippocampus,dependent
R1229 T4272 T4270 punct -,hippocampus
R1230 T4273 T4270 cc or,hippocampus
R1231 T4274 T4270 conj cerebellum,hippocampus
R1232 T4275 T4271 punct -,dependent
R1233 T4276 T4262 dobj analyses,applied
R1234 T4277 T4276 amod behavioural,analyses
R1235 T4278 T4262 punct .,applied
R1236 T5242 T5243 amod Spatial,learning
R1237 T5244 T5243 prep in,learning
R1238 T5245 T5246 npadvmod ADAM11,deficient
R1239 T5246 T5248 amod deficient,mice
R1240 T5247 T5246 punct -,deficient
R1241 T5248 T5244 pobj mice,in
R1242 T5250 T5251 aux To,study
R1243 T5251 T5252 advcl study,examined
R1244 T5253 T5254 det the,functions
R1245 T5254 T5251 dobj functions,study
R1246 T5255 T5254 prep of,functions
R1247 T5256 T5255 pobj ADAM11,of
R1248 T5257 T5251 prep in,study
R1249 T5258 T5259 det the,hippocampus
R1250 T5259 T5257 pobj hippocampus,in
R1251 T5260 T5252 punct ", ",examined
R1252 T5261 T5252 nsubj we,examined
R1253 T5262 T5263 det the,ability
R1254 T5263 T5252 dobj ability,examined
R1255 T5264 T5265 amod spatial,learning
R1256 T5265 T5263 compound learning,ability
R1257 T5266 T5263 prep of,ability
R1258 T5267 T5268 npadvmod ADAM11,deficient
R1259 T5268 T5270 amod deficient,mice
R1260 T5269 T5268 punct -,deficient
R1261 T5270 T5266 pobj mice,of
R1262 T5271 T5252 advcl using,examined
R1263 T5272 T5273 det the,task
R1264 T5273 T5271 dobj task,using
R1265 T5274 T5275 compound Morris,Maze
R1266 T5275 T5273 compound Maze,task
R1267 T5276 T5275 compound Water,Maze
R1268 T5277 T5278 punct [,27
R1269 T5278 T5271 parataxis 27,using
R1270 T5279 T5278 punct ],27
R1271 T5280 T5252 punct .,examined
R1272 T5282 T5283 advmod First,trained
R1273 T5284 T5283 punct ", ",trained
R1274 T5285 T5283 nsubjpass mice,trained
R1275 T5286 T5283 auxpass were,trained
R1276 T5287 T5283 prep in,trained
R1277 T5288 T5289 det a,task
R1278 T5289 T5287 pobj task,in
R1279 T5290 T5291 amod hidden,platform
R1280 T5291 T5289 compound platform,task
R1281 T5292 T5289 punct ", ",task
R1282 T5293 T5294 prep in,searched
R1283 T5294 T5289 relcl searched,task
R1284 T5295 T5293 pobj which,in
R1285 T5296 T5294 nsubj mice,searched
R1286 T5297 T5294 prep for,searched
R1287 T5298 T5299 det a,platform
R1288 T5299 T5297 pobj platform,for
R1289 T5300 T5299 amod submerged,platform
R1290 T5301 T5302 aux to,escape
R1291 T5302 T5294 advcl escape,searched
R1292 T5303 T5302 prep from,escape
R1293 T5304 T5305 det the,water
R1294 T5305 T5303 pobj water,from
R1295 T5306 T5283 punct .,trained
R1296 T5308 T5309 nmod Adam11,mice
R1297 T5309 T5315 nsubjpass mice,found
R1298 T5310 T5308 punct (,Adam11
R1299 T5311 T5308 punct -,Adam11
R1300 T5312 T5308 punct /,Adam11
R1301 T5313 T5308 punct -,Adam11
R1302 T5314 T5308 punct ),Adam11
R1303 T5316 T5315 auxpass were,found
R1304 T5317 T5318 aux to,take
R1305 T5318 T5315 xcomp take,found
R1306 T5319 T5320 det a,time
R1307 T5320 T5318 dobj time,take
R1308 T5321 T5322 advmod significantly,longer
R1309 T5322 T5320 amod longer,time
R1310 T5323 T5324 aux to,locate
R1311 T5324 T5320 advcl locate,time
R1312 T5325 T5326 det the,platform
R1313 T5326 T5324 dobj platform,locate
R1314 T5327 T5326 amod hidden,platform
R1315 T5328 T5320 prep than,time
R1316 T5329 T5330 punct (,mice
R1317 T5330 T5328 pobj mice,than
R1318 T5331 T5332 punct +,+
R1319 T5332 T5330 punct +,mice
R1320 T5333 T5332 punct /,+
R1321 T5334 T5332 punct ),+
R1322 T5335 T5332 cc and,+
R1323 T5336 T5337 punct (,-
R1324 T5337 T5332 conj -,+
R1325 T5338 T5337 punct +,-
R1326 T5339 T5337 punct /,-
R1327 T5340 T5330 punct ),mice
R1328 T5341 T5342 punct (,2A
R1329 T5342 T5318 parataxis 2A,take
R1330 T5343 T5342 compound Fig.,2A
R1331 T5344 T5342 punct ),2A
R1332 T5345 T5315 punct .,found
R1333 T5347 T5348 advmod Nonetheless,improved
R1334 T5349 T5348 punct ", ",improved
R1335 T5350 T5351 det the,ability
R1336 T5351 T5348 nsubj ability,improved
R1337 T5352 T5351 prep of,ability
R1338 T5353 T5354 punct (,mice
R1339 T5354 T5352 pobj mice,of
R1340 T5355 T5356 punct +,+
R1341 T5356 T5354 punct +,mice
R1342 T5357 T5356 punct /,+
R1343 T5358 T5356 punct ),+
R1344 T5359 T5356 punct ", ",+
R1345 T5360 T5361 punct (,-
R1346 T5361 T5356 conj -,+
R1347 T5362 T5361 punct +,-
R1348 T5363 T5361 punct /,-
R1349 T5364 T5361 punct ),-
R1350 T5365 T5361 cc and,-
R1351 T5366 T5367 punct (,-
R1352 T5367 T5361 conj -,-
R1353 T5368 T5367 punct -,-
R1354 T5369 T5367 punct /,-
R1355 T5370 T5354 punct ),mice
R1356 T5371 T5372 aux to,find
R1357 T5372 T5351 acl find,ability
R1358 T5373 T5374 det the,platform
R1359 T5374 T5372 dobj platform,find
R1360 T5375 T5374 amod hidden,platform
R1361 T5376 T5348 prep over,improved
R1362 T5377 T5378 compound test,sessions
R1363 T5378 T5376 pobj sessions,over
R1364 T5379 T5380 punct (,2A
R1365 T5380 T5348 parataxis 2A,improved
R1366 T5381 T5380 compound Fig.,2A
R1367 T5382 T5380 punct ),2A
R1368 T5383 T5348 punct .,improved
R1369 T5385 T5386 advmod Thus,were
R1370 T5387 T5386 punct ", ",were
R1371 T5388 T5389 punct (,mice
R1372 T5389 T5386 nsubj mice,were
R1373 T5390 T5391 punct +,+
R1374 T5391 T5389 punct +,mice
R1375 T5392 T5391 punct /,+
R1376 T5393 T5391 punct ),+
R1377 T5394 T5391 punct ", ",+
R1378 T5395 T5396 punct (,-
R1379 T5396 T5391 conj -,+
R1380 T5397 T5396 punct +,-
R1381 T5398 T5396 punct /,-
R1382 T5399 T5396 punct ),-
R1383 T5400 T5396 cc and,-
R1384 T5401 T5402 punct (,-
R1385 T5402 T5396 conj -,-
R1386 T5403 T5402 punct -,-
R1387 T5404 T5402 punct /,-
R1388 T5405 T5389 punct ),mice
R1389 T5406 T5386 acomp able,were
R1390 T5407 T5408 aux to,learn
R1391 T5408 T5406 xcomp learn,able
R1392 T5409 T5410 det the,location
R1393 T5410 T5408 dobj location,learn
R1394 T5411 T5410 prep of,location
R1395 T5412 T5413 det the,platform
R1396 T5413 T5411 pobj platform,of
R1397 T5414 T5413 amod hidden,platform
R1398 T5415 T5408 prep during,learn
R1399 T5416 T5417 det the,course
R1400 T5417 T5415 pobj course,during
R1401 T5418 T5417 prep of,course
R1402 T5419 T5420 det the,trials
R1403 T5420 T5418 pobj trials,of
R1404 T5421 T5386 punct ", ",were
R1405 T5422 T5423 mark although,was
R1406 T5423 T5386 advcl was,were
R1407 T5424 T5425 det the,capacity
R1408 T5425 T5423 nsubj capacity,was
R1409 T5426 T5425 prep of,capacity
R1410 T5427 T5426 punct (,of
R1411 T5428 T5429 punct -,-
R1412 T5429 T5431 punct -,mice
R1413 T5430 T5429 punct /,-
R1414 T5431 T5426 pobj mice,of
R1415 T5432 T5431 punct ),mice
R1416 T5433 T5434 aux to,find
R1417 T5434 T5425 acl find,capacity
R1418 T5435 T5436 det the,platform
R1419 T5436 T5434 dobj platform,find
R1420 T5437 T5423 acomp lower,was
R1421 T5438 T5437 prep than,lower
R1422 T5439 T5438 pobj that,than
R1423 T5440 T5439 prep of,that
R1424 T5441 T5442 punct (,mice
R1425 T5442 T5440 pobj mice,of
R1426 T5443 T5444 punct +,+
R1427 T5444 T5442 punct +,mice
R1428 T5445 T5444 punct /,+
R1429 T5446 T5444 punct ),+
R1430 T5447 T5444 cc and,+
R1431 T5448 T5449 punct (,-
R1432 T5449 T5444 conj -,+
R1433 T5450 T5449 punct +,-
R1434 T5451 T5449 punct /,-
R1435 T5452 T5442 punct ),mice
R1436 T5453 T5386 punct .,were
R1437 T5455 T5456 nsubj We,performed
R1438 T5457 T5456 advmod further,performed
R1439 T5458 T5459 det a,test
R1440 T5459 T5456 dobj test,performed
R1441 T5460 T5459 compound probe,test
R1442 T5461 T5459 punct ", ",test
R1443 T5462 T5463 prep in,removed
R1445 T5464 T5462 pobj which,in
R1446 T5465 T5466 det the,platform
R1447 T5466 T5463 nsubjpass platform,removed
R1448 T5467 T5463 auxpass was,removed
R1449 T5468 T5463 prep from,removed
R1450 T5469 T5470 det the,pool
R1451 T5470 T5468 pobj pool,from
R1452 T5471 T5463 prep after,removed
R1453 T5472 T5471 pobj completion,after
R1454 T5473 T5472 prep of,completion
R1455 T5474 T5475 det the,task
R1456 T5475 T5473 pobj task,of
R1457 T5476 T5477 amod hidden,platform
R1458 T5477 T5475 compound platform,task
R1459 T5478 T5456 punct ", ",performed
R1460 T5479 T5456 cc and,performed
R1461 T5480 T5481 det the,mice
R1462 T5481 T5483 nsubjpass mice,allowed
R1463 T5482 T5481 amod trained,mice
R1464 T5483 T5456 conj allowed,performed
R1465 T5484 T5483 auxpass were,allowed
R1466 T5485 T5486 aux to,swim
R1467 T5486 T5483 xcomp swim,allowed
R1468 T5487 T5486 advmod freely,swim
R1469 T5488 T5486 prep for,swim
R1470 T5489 T5490 nummod 60,sec
R1471 T5490 T5488 pobj sec,for
R1472 T5491 T5483 punct .,allowed
R1473 T5493 T5494 det The,time
R1474 T5494 T5495 nsubj time,is
R1475 T5496 T5494 acl spent,time
R1476 T5497 T5496 prep in,spent
R1477 T5498 T5499 det the,quadrant
R1478 T5499 T5497 pobj quadrant,in
R1479 T5500 T5499 compound target,quadrant
R1480 T5501 T5494 prep of,time
R1481 T5502 T5501 punct (,of
R1482 T5503 T5504 punct -,-
R1483 T5504 T5501 punct -,of
R1484 T5505 T5504 punct /,-
R1485 T5506 T5495 punct ),is
R1486 T5507 T5508 advmod significantly,lower
R1487 T5508 T5495 acomp lower,is
R1488 T5509 T5508 prep than,lower
R1489 T5510 T5509 pobj that,than
R1490 T5511 T5510 prep of,that
R1491 T5512 T5513 punct (,mice
R1493 T5514 T5515 punct +,+
R1494 T5515 T5513 punct +,mice
R1495 T5516 T5515 punct /,+
R1496 T5517 T5513 punct ),mice
R1497 T5518 T5519 punct (,2B
R1498 T5519 T5495 parataxis 2B,is
R1499 T5520 T5519 compound Fig.,2B
R1500 T5521 T5519 punct ),2B
R1501 T5522 T5495 punct .,is
R1502 T5524 T5525 nmod Adam11,mice
R1503 T5525 T5531 nsubj mice,appeared
R1504 T5526 T5524 punct (,Adam11
R1505 T5527 T5524 punct +,Adam11
R1506 T5528 T5524 punct /,Adam11
R1507 T5529 T5524 punct -,Adam11
R1508 T5530 T5525 punct ),mice
R1509 T5532 T5533 aux to,spend
R1510 T5533 T5531 xcomp spend,appeared
R1511 T5534 T5535 det a,time
R1512 T5535 T5533 dobj time,spend
R1513 T5536 T5535 amod shorter,time
R1514 T5537 T5533 prep in,spend
R1515 T5538 T5539 det the,quadrant
R1516 T5539 T5537 pobj quadrant,in
R1517 T5540 T5539 compound target,quadrant
R1518 T5541 T5531 punct ", ",appeared
R1519 T5542 T5531 cc but,appeared
R1520 T5543 T5544 expl there,was
R1521 T5544 T5531 conj was,appeared
R1522 T5545 T5546 det no,difference
R1523 T5546 T5544 attr difference,was
R1524 T5547 T5546 amod significant,difference
R1525 T5548 T5546 prep between,difference
R1526 T5549 T5548 punct (,between
R1527 T5550 T5551 punct +,+
R1528 T5551 T5553 punct +,mice
R1529 T5552 T5551 punct /,+
R1530 T5553 T5548 pobj mice,between
R1531 T5554 T5551 punct ),+
R1532 T5555 T5551 cc and,+
R1533 T5556 T5557 punct (,-
R1534 T5557 T5551 conj -,+
R1535 T5558 T5557 punct +,-
R1536 T5559 T5557 punct /,-
R1537 T5560 T5553 punct ),mice
R1538 T5561 T5562 punct (,2B
R1539 T5562 T5544 parataxis 2B,was
R1540 T5563 T5562 compound Fig.,2B
R1541 T5564 T5562 punct ),2B
R1542 T5565 T5544 punct .,was
R1543 T5567 T5568 det These,results
R1544 T5568 T5569 nsubj results,indicate
R1545 T5570 T5571 det a,impairment
R1546 T5571 T5569 dobj impairment,indicate
R1547 T5572 T5573 amod spatial,learning
R1548 T5573 T5571 compound learning,impairment
R1549 T5574 T5569 prep in,indicate
R1550 T5575 T5576 punct (,mice
R1552 T5577 T5578 punct -,-
R1553 T5578 T5576 punct -,mice
R1554 T5579 T5578 punct /,-
R1555 T5580 T5576 punct ),mice
R1556 T5581 T5569 punct .,indicate
R1557 T5583 T5584 det The,distance
R1558 T5584 T5586 nsubj distance,was
R1559 T5585 T5584 compound swimming,distance
R1560 T5587 T5584 prep of,distance
R1561 T5588 T5589 punct (,mice
R1562 T5589 T5587 pobj mice,of
R1563 T5590 T5591 punct +,+
R1564 T5591 T5589 punct +,mice
R1565 T5592 T5591 punct /,+
R1566 T5593 T5591 punct ),+
R1567 T5594 T5591 punct ", ",+
R1568 T5595 T5596 punct (,-
R1569 T5596 T5591 conj -,+
R1570 T5597 T5596 punct +,-
R1571 T5598 T5596 punct /,-
R1572 T5599 T5596 punct ),-
R1573 T5600 T5596 cc and,-
R1574 T5601 T5602 punct (,-
R1575 T5602 T5596 conj -,-
R1576 T5603 T5602 punct -,-
R1577 T5604 T5602 punct /,-
R1578 T5605 T5589 punct ),mice
R1579 T5606 T5586 punct ", ",was
R1580 T5607 T5586 advmod however,was
R1581 T5608 T5586 punct ", ",was
R1582 T5609 T5586 acomp similar,was
R1583 T5610 T5586 prep during,was
R1584 T5611 T5612 det the,trial
R1585 T5612 T5610 pobj trial,during
R1586 T5613 T5612 compound probe,trial
R1587 T5614 T5615 punct (,2C
R1588 T5615 T5586 parataxis 2C,was
R1589 T5616 T5615 compound Fig.,2C
R1590 T5617 T5615 punct ),2C
R1591 T5618 T5586 punct .,was
R1592 T5620 T5621 prep In,improved
R1593 T5622 T5623 det the,task
R1594 T5623 T5620 pobj task,In
R1595 T5624 T5625 amod visible,platform
R1596 T5625 T5623 compound platform,task
R1597 T5626 T5621 punct ", ",improved
R1598 T5627 T5628 det the,performance
R1599 T5628 T5621 nsubj performance,improved
R1600 T5629 T5628 prep of,performance
R1601 T5630 T5629 pobj mice,of
R1602 T5631 T5630 prep with,mice
R1603 T5632 T5633 punct (,genotypes
R1604 T5633 T5631 pobj genotypes,with
R1605 T5634 T5635 punct +,+
R1606 T5635 T5633 punct +,genotypes
R1607 T5636 T5635 punct /,+
R1608 T5637 T5635 punct ),+
R1609 T5638 T5635 punct ", ",+
R1610 T5639 T5640 punct (,-
R1611 T5640 T5635 conj -,+
R1612 T5641 T5640 punct +,-
R1613 T5642 T5640 punct /,-
R1614 T5643 T5640 punct ),-
R1615 T5644 T5640 cc and,-
R1616 T5645 T5646 punct (,-
R1617 T5646 T5640 conj -,-
R1618 T5647 T5646 punct -,-
R1619 T5648 T5646 punct /,-
R1620 T5649 T5633 punct ),genotypes
R1621 T5650 T5621 prep during,improved
R1622 T5651 T5652 det the,course
R1623 T5652 T5650 pobj course,during
R1624 T5653 T5652 prep of,course
R1625 T5654 T5655 det the,sessions
R1626 T5655 T5653 pobj sessions,of
R1627 T5656 T5655 compound test,sessions
R1628 T5657 T5621 punct ", ",improved
R1629 T5658 T5659 mark as,indicated
R1630 T5659 T5621 advcl indicated,improved
R1631 T5660 T5659 agent by,indicated
R1632 T5661 T5662 det a,decrease
R1633 T5662 T5660 pobj decrease,by
R1634 T5663 T5662 amod progressive,decrease
R1635 T5664 T5662 prep in,decrease
R1636 T5665 T5666 det the,latency
R1637 T5666 T5664 pobj latency,in
R1638 T5667 T5666 prep for,latency
R1639 T5668 T5667 pcomp locating,for
R1640 T5669 T5670 det the,platform
R1641 T5670 T5668 dobj platform,locating
R1642 T5671 T5672 punct (,2D
R1643 T5672 T5659 parataxis 2D,indicated
R1644 T5673 T5672 compound Fig.,2D
R1645 T5674 T5672 punct ),2D
R1646 T5675 T5621 punct ", ",improved
R1647 T5676 T5621 advcl suggesting,improved
R1648 T5677 T5678 mark that,learn
R1649 T5678 T5676 ccomp learn,suggesting
R1650 T5679 T5680 punct (,mice
R1651 T5680 T5678 nsubj mice,learn
R1652 T5681 T5682 punct -,-
R1653 T5682 T5680 punct -,mice
R1654 T5683 T5682 punct /,-
R1655 T5684 T5680 punct ),mice
R1656 T5685 T5686 det this,task
R1657 T5686 T5678 dobj task,learn
R1658 T5687 T5688 amod visible,platform
R1659 T5688 T5686 compound platform,task
R1660 T5689 T5690 advmod just,well
R1661 T5690 T5678 advmod well,learn
R1662 T5691 T5690 advmod as,well
R1663 T5692 T5690 prep as,well
R1664 T5693 T5694 punct (,mice
R1665 T5694 T5692 pobj mice,as
R1666 T5695 T5696 punct +,+
R1667 T5696 T5694 punct +,mice
R1668 T5697 T5696 punct /,+
R1669 T5698 T5696 punct ),+
R1670 T5699 T5696 cc and,+
R1671 T5700 T5701 punct (,-
R1672 T5701 T5696 conj -,+
R1673 T5702 T5701 punct +,-
R1674 T5703 T5701 punct /,-
R1675 T5704 T5694 punct ),mice
R1676 T5705 T5621 punct .,improved
R1677 T5707 T5708 det These,results
R1678 T5708 T5709 nsubj results,indicated
R1679 T5710 T5709 advmod also,indicated
R1680 T5711 T5712 mark that,have
R1681 T5712 T5709 ccomp have,indicated
R1682 T5713 T5714 punct (,mice
R1683 T5714 T5712 nsubj mice,have
R1684 T5715 T5716 punct -,-
R1685 T5716 T5714 punct -,mice
R1686 T5717 T5716 punct /,-
R1687 T5718 T5714 punct ),mice
R1688 T5719 T5720 amod normal,function
R1689 T5720 T5712 dobj function,have
R1690 T5721 T5720 amod visible,function
R1691 T5722 T5721 cc and,visible
R1692 T5723 T5721 conj motor,visible
R1693 T5724 T5720 cc and,function
R1694 T5725 T5726 det the,motivation
R1695 T5726 T5720 conj motivation,function
R1696 T5727 T5726 acl needed,motivation
R1697 T5728 T5727 prep in,needed
R1698 T5729 T5730 det the,task
R1699 T5730 T5728 pobj task,in
R1700 T5731 T5732 compound water,maze
R1701 T5732 T5730 compound maze,task
R1702 T5733 T5709 punct .,indicated
R1703 T6623 T6624 compound Motor,function
R1704 T6625 T6624 prep of,function
R1705 T6626 T6627 npadvmod ADAM11,deficient
R1706 T6627 T6629 amod deficient,mice
R1707 T6628 T6627 punct -,deficient
R1708 T6629 T6625 pobj mice,of
R1709 T6631 T6632 aux To,study
R1710 T6632 T6633 advcl study,examined
R1711 T6634 T6635 det the,functions
R1712 T6635 T6632 dobj functions,study
R1713 T6636 T6635 prep of,functions
R1714 T6637 T6636 pobj ADAM11,of
R1715 T6638 T6632 prep in,study
R1716 T6639 T6640 det the,cerebellum
R1717 T6640 T6638 pobj cerebellum,in
R1718 T6641 T6633 punct ", ",examined
R1719 T6642 T6633 nsubj we,examined
R1720 T6643 T6644 det the,function
R1721 T6644 T6633 dobj function,examined
R1722 T6645 T6644 amod motor,function
R1723 T6646 T6644 prep of,function
R1724 T6647 T6648 npadvmod ADAM11,deficient
R1725 T6648 T6650 amod deficient,mice
R1726 T6649 T6648 punct -,deficient
R1727 T6650 T6646 pobj mice,of
R1728 T6651 T6633 advcl using,examined
R1729 T6652 T6653 det a,task
R1730 T6653 T6651 dobj task,using
R1731 T6654 T6655 amod rotating,rod
R1732 T6655 T6653 compound rod,task
R1733 T6656 T6657 punct [,28
R1734 T6657 T6633 parataxis 28,examined
R1735 T6658 T6657 punct ],28
R1736 T6659 T6633 punct .,examined
R1737 T6661 T6662 prep In,was
R1738 T6663 T6664 det the,test
R1739 T6664 T6661 pobj test,In
R1740 T6665 T6666 amod rotating,rod
R1741 T6666 T6664 compound rod,test
R1742 T6667 T6662 punct ", ",was
R1743 T6668 T6669 det the,time
R1744 T6669 T6662 nsubj time,was
R1745 T6670 T6669 compound retention,time
R1746 T6671 T6669 prep of,time
R1747 T6672 T6673 punct (,mice
R1748 T6673 T6671 pobj mice,of
R1749 T6674 T6675 punct +,-
R1750 T6675 T6673 punct -,mice
R1751 T6676 T6675 punct /,-
R1752 T6677 T6675 punct ),-
R1753 T6678 T6675 cc and,-
R1754 T6679 T6680 punct (,-
R1755 T6680 T6675 conj -,-
R1756 T6681 T6680 punct -,-
R1757 T6682 T6680 punct /,-
R1758 T6683 T6673 punct ),mice
R1759 T6684 T6673 prep on,mice
R1760 T6685 T6686 det the,rod
R1761 T6686 T6684 pobj rod,on
R1762 T6687 T6662 neg not,was
R1763 T6688 T6689 advmod significantly,different
R1764 T6689 T6662 acomp different,was
R1765 T6690 T6689 prep from,different
R1766 T6691 T6690 pobj that,from
R1767 T6692 T6691 prep of,that
R1768 T6693 T6694 punct (,mice
R1770 T6695 T6696 punct +,+
R1771 T6696 T6694 punct +,mice
R1772 T6697 T6696 punct /,+
R1773 T6698 T6694 punct ),mice
R1774 T6699 T6662 prep at,was
R1775 T6700 T6701 nummod 0,rpm
R1776 T6701 T6699 pobj rpm,at
R1777 T6702 T6703 punct (,stationary
R1778 T6703 T6701 parataxis stationary,rpm
R1779 T6704 T6703 punct ),stationary
R1780 T6705 T6706 punct [,0.96
R1781 T6706 T6662 parataxis 0.96,was
R1782 T6707 T6708 punct +,-
R1783 T6708 T6710 punct -,0.21
R1784 T6709 T6708 punct /,-
R1785 T6710 T6706 dep 0.21,0.96
R1786 T6711 T6710 punct : ,0.21
R1787 T6712 T6713 nsubj F,1.67
R1789 T6714 T6712 punct (,F
R1790 T6715 T6712 nummod 1,F
R1791 T6716 T6712 punct ", ",F
R1792 T6717 T6712 nummod 80,F
R1793 T6718 T6712 punct ),F
R1794 T6719 T6713 punct =,1.67
R1795 T6720 T6710 punct ", ",0.21
R1796 T6721 T6710 nsubj p,0.21
R1797 T6722 T6710 punct =,0.21
R1798 T6723 T6706 punct ;,0.96
R1799 T6724 T6725 punct -,-
R1800 T6725 T6706 punct -,0.96
R1801 T6726 T6725 punct /,-
R1802 T6727 T6706 punct : ,0.96
R1803 T6728 T6729 nsubj F,0.002
R1804 T6729 T6706 ccomp 0.002,0.96
R1805 T6730 T6728 punct (,F
R1806 T6731 T6728 nummod 1,F
R1807 T6732 T6728 punct ", ",F
R1808 T6733 T6728 nummod 88,F
R1809 T6734 T6728 punct ),F
R1810 T6735 T6729 punct =,0.002
R1811 T6736 T6706 punct ", ",0.96
R1812 T6737 T6706 nsubj p,0.96
R1813 T6738 T6706 punct =,0.96
R1814 T6739 T6706 punct ],0.96
R1815 T6740 T6741 punct (,3A
R1816 T6741 T6662 parataxis 3A,was
R1817 T6742 T6741 compound Fig.,3A
R1818 T6743 T6741 punct ),3A
R1819 T6744 T6662 punct .,was
R1820 T6746 T6747 prep In,seen
R1821 T6748 T6749 punct (,mice
R1823 T6750 T6751 punct +,-
R1824 T6751 T6749 punct -,mice
R1825 T6752 T6751 punct /,-
R1826 T6753 T6749 punct ),mice
R1827 T6754 T6747 punct ", ",seen
R1828 T6755 T6756 det the,tendency
R1829 T6756 T6747 nsubjpass tendency,seen
R1830 T6757 T6756 prep of,tendency
R1831 T6758 T6759 amod decreased,times
R1832 T6759 T6757 pobj times,of
R1833 T6760 T6759 compound retention,times
R1834 T6761 T6747 auxpass was,seen
R1835 T6762 T6747 prep at,seen
R1836 T6763 T6764 nummod 5,rpm
R1838 T6765 T6763 punct ", ",5
R1839 T6766 T6763 conj 10,5
R1840 T6767 T6766 cc and,10
R1841 T6768 T6766 conj 15,10
R1842 T6769 T6747 punct ", ",seen
R1843 T6770 T6747 cc but,seen
R1844 T6771 T6772 expl there,was
R1845 T6772 T6747 conj was,seen
R1846 T6773 T6774 det no,difference
R1847 T6774 T6772 attr difference,was
R1848 T6775 T6774 amod significant,difference
R1849 T6776 T6774 prep between,difference
R1850 T6777 T6778 punct (,mice
R1851 T6778 T6776 pobj mice,between
R1852 T6779 T6780 punct +,+
R1853 T6780 T6778 punct +,mice
R1854 T6781 T6780 punct /,+
R1855 T6782 T6780 punct ),+
R1856 T6783 T6780 cc and,+
R1857 T6784 T6785 punct (,-
R1858 T6785 T6780 conj -,+
R1859 T6786 T6785 punct +,-
R1860 T6787 T6785 punct /,-
R1861 T6788 T6778 punct ),mice
R1862 T6789 T6790 punct [,0.11
R1863 T6790 T6772 parataxis 0.11,was
R1864 T6791 T6792 nummod 5,rpm
R1865 T6792 T6793 dep rpm,0.27
R1866 T6793 T6790 dep 0.27,0.11
R1867 T6794 T6793 punct : ,0.27
R1868 T6795 T6796 nsubj F,1.27
R1870 T6797 T6795 punct (,F
R1871 T6798 T6795 nummod 1,F
R1872 T6799 T6795 punct ", ",F
R1873 T6800 T6795 nummod 20,F
R1874 T6801 T6795 punct ),F
R1875 T6802 T6796 punct =,1.27
R1876 T6803 T6793 punct ", ",0.27
R1877 T6804 T6793 nsubj p,0.27
R1878 T6805 T6793 punct =,0.27
R1879 T6806 T6790 punct ;,0.11
R1880 T6807 T6808 nummod 10,rpm
R1881 T6808 T6809 dep rpm,0.31
R1882 T6809 T6790 dep 0.31,0.11
R1883 T6810 T6809 punct : ,0.31
R1884 T6811 T6812 nsubj F,1.07
R1886 T6813 T6811 punct (,F
R1887 T6814 T6811 nummod 1,F
R1888 T6815 T6811 punct ", ",F
R1889 T6816 T6811 nummod 20,F
R1890 T6817 T6811 punct ),F
R1891 T6818 T6812 punct =,1.07
R1892 T6819 T6809 punct ", ",0.31
R1893 T6820 T6809 nsubj p,0.31
R1894 T6821 T6809 punct =,0.31
R1895 T6822 T6790 punct ;,0.11
R1896 T6823 T6824 nummod 15,rpm
R1897 T6824 T6790 dep rpm,0.11
R1898 T6825 T6790 punct : ,0.11
R1899 T6826 T6827 nsubj F,2.716
R1900 T6827 T6790 ccomp 2.716,0.11
R1901 T6828 T6826 punct (,F
R1902 T6829 T6826 nummod 1,F
R1903 T6830 T6826 punct ", ",F
R1904 T6831 T6826 nummod 20,F
R1905 T6832 T6827 punct ),2.716
R1906 T6833 T6827 punct =,2.716
R1907 T6834 T6790 punct ", ",0.11
R1908 T6835 T6790 nsubj p,0.11
R1909 T6836 T6790 punct =,0.11
R1910 T6837 T6790 punct ],0.11
R1911 T6838 T6839 punct (,3B
R1912 T6839 T6772 parataxis 3B,was
R1913 T6840 T6839 compound Figs.,3B
R1914 T6841 T6839 punct ", ",3B
R1915 T6842 T6839 conj 3C,3B
R1916 T6843 T6842 cc and,3C
R1917 T6844 T6842 conj 3D,3C
R1918 T6845 T6839 punct ),3B
R1919 T6846 T6772 punct .,was
R1920 T6848 T6849 advmod However,fell
R1921 T6850 T6849 punct ", ",fell
R1922 T6851 T6852 punct (,mice
R1924 T6853 T6854 punct -,-
R1925 T6854 T6852 punct -,mice
R1926 T6855 T6854 punct /,-
R1927 T6856 T6852 punct ),mice
R1928 T6857 T6858 advmod more,quickly
R1929 T6858 T6849 advmod quickly,fell
R1930 T6859 T6849 prep from,fell
R1931 T6860 T6861 det the,rod
R1932 T6861 T6859 pobj rod,from
R1933 T6862 T6849 prep than,fell
R1934 T6863 T6862 punct (,than
R1935 T6864 T6865 punct +,+
R1936 T6865 T6867 punct +,mice
R1937 T6866 T6865 punct /,+
R1938 T6867 T6862 pobj mice,than
R1939 T6868 T6867 punct ),mice
R1940 T6869 T6849 prep at,fell
R1941 T6870 T6871 nummod 5,rpm
R1943 T6872 T6870 punct ", ",5
R1944 T6873 T6870 conj 10,5
R1945 T6874 T6873 cc and,10
R1946 T6875 T6873 conj 15,10
R1947 T6876 T6877 punct [,0.0002
R1948 T6877 T6849 parataxis 0.0002,fell
R1949 T6878 T6879 nummod 5,rpm
R1950 T6879 T6880 dep rpm,0.0002
R1951 T6880 T6877 dep 0.0002,0.0002
R1952 T6881 T6880 punct : ,0.0002
R1953 T6882 T6883 nsubj F,17.51
R1955 T6884 T6882 punct (,F
R1956 T6885 T6882 nummod 1,F
R1957 T6886 T6882 punct ", ",F
R1958 T6887 T6882 nummod 27.3,F
R1959 T6888 T6883 punct ),17.51
R1960 T6889 T6883 punct =,17.51
R1961 T6890 T6880 punct ", ",0.0002
R1962 T6891 T6880 nsubj p,0.0002
R1963 T6892 T6880 punct =,0.0002
R1964 T6893 T6877 punct ;,0.0002
R1965 T6894 T6895 nummod 10,rpm
R1966 T6895 T6896 dep rpm,0.003
R1967 T6896 T6877 dep 0.003,0.0002
R1968 T6897 T6896 punct : ,0.003
R1969 T6898 T6899 nsubj F,11.05
R1971 T6900 T6898 punct (,F
R1972 T6901 T6898 nummod 1,F
R1973 T6902 T6898 punct ", ",F
R1974 T6903 T6898 nummod 22,F
R1975 T6904 T6899 punct ),11.05
R1976 T6905 T6899 punct =,11.05
R1977 T6906 T6896 punct ", ",0.003
R1978 T6907 T6896 nsubj p,0.003
R1979 T6908 T6896 punct =,0.003
R1980 T6909 T6877 punct ;,0.0002
R1981 T6910 T6911 nummod 15,rpm
R1982 T6911 T6877 dep rpm,0.0002
R1983 T6912 T6877 punct : ,0.0002
R1984 T6913 T6914 nsubj F,19.22
R1985 T6914 T6877 ccomp 19.22,0.0002
R1986 T6915 T6913 punct (,F
R1987 T6916 T6913 nummod 1,F
R1988 T6917 T6913 punct ", ",F
R1989 T6918 T6913 nummod 22,F
R1990 T6919 T6913 punct ),F
R1991 T6920 T6914 punct =,19.22
R1992 T6921 T6877 punct ", ",0.0002
R1993 T6922 T6877 nsubj p,0.0002
R1994 T6923 T6877 punct =,0.0002
R1995 T6924 T6877 punct ],0.0002
R1996 T6925 T6926 punct (,3B
R1997 T6926 T6849 parataxis 3B,fell
R1998 T6927 T6926 compound Figs.,3B
R1999 T6928 T6926 punct ", ",3B
R2000 T6929 T6926 conj 3C,3B
R2001 T6930 T6929 cc and,3C
R2002 T6931 T6929 conj 3D,3C
R2003 T6932 T6926 punct ),3B
R2004 T6933 T6849 punct .,fell
R2005 T6935 T6936 det The,time
R2006 T6936 T6938 nsubjpass time,improved
R2007 T6937 T6936 compound retention,time
R2008 T6939 T6938 auxpass was,improved
R2009 T6940 T6938 neg not,improved
R2010 T6941 T6938 advmod significantly,improved
R2011 T6942 T6938 prep in,improved
R2012 T6943 T6944 punct (,mice
R2014 T6945 T6946 punct -,-
R2015 T6946 T6944 punct -,mice
R2016 T6947 T6946 punct /,-
R2017 T6948 T6944 punct ),mice
R2018 T6949 T6938 prep across,improved
R2019 T6950 T6949 pobj trials,across
R2020 T6951 T6950 prep of,trials
R2021 T6952 T6951 pobj training,of
R2022 T6953 T6950 prep at,trials
R2023 T6954 T6955 nummod 5,rpm
R2025 T6956 T6954 punct ", ",5
R2026 T6957 T6954 conj 10,5
R2027 T6958 T6957 cc and,10
R2028 T6959 T6957 conj 15,10
R2029 T6960 T6961 punct [,0.14
R2030 T6961 T6938 parataxis 0.14,improved
R2031 T6962 T6963 nummod 5,rpm
R2032 T6963 T6964 dep rpm,0.15
R2033 T6964 T6961 dep 0.15,0.14
R2034 T6965 T6964 punct : ,0.15
R2035 T6966 T6967 nsubj F,2.05
R2037 T6968 T6966 punct (,F
R2038 T6969 T6966 nummod 3,F
R2039 T6970 T6966 punct ", ",F
R2040 T6971 T6966 nummod 15.3,F
R2041 T6972 T6966 punct ),F
R2042 T6973 T6967 punct =,2.05
R2043 T6974 T6964 punct ", ",0.15
R2044 T6975 T6964 nsubj p,0.15
R2045 T6976 T6964 punct =,0.15
R2046 T6977 T6961 punct ;,0.14
R2047 T6978 T6979 nummod 10,rpm
R2048 T6979 T6980 dep rpm,0.07
R2049 T6980 T6961 dep 0.07,0.14
R2050 T6981 T6980 punct : ,0.07
R2051 T6982 T6983 nsubj F,2.61
R2053 T6984 T6982 punct (,F
R2054 T6985 T6982 nummod 7,F
R2055 T6986 T6982 punct ", ",F
R2056 T6987 T6982 nummod 11,F
R2057 T6988 T6982 punct ),F
R2058 T6989 T6983 punct =,2.61
R2059 T6990 T6980 punct ", ",0.07
R2060 T6991 T6980 nsubj p,0.07
R2061 T6992 T6980 punct =,0.07
R2062 T6993 T6961 punct ;,0.14
R2063 T6994 T6995 nummod 15,rpm
R2064 T6995 T6961 dep rpm,0.14
R2065 T6996 T6961 punct : ,0.14
R2066 T6997 T6998 nsubj F,1.57
R2067 T6998 T6961 ccomp 1.57,0.14
R2068 T6999 T6997 punct (,F
R2069 T7000 T6997 nummod 19,F
R2070 T7001 T6997 punct ", ",F
R2071 T7002 T6997 nummod 26.6,F
R2072 T7003 T6997 punct ),F
R2073 T7004 T6998 punct =,1.57
R2074 T7005 T6961 punct ", ",0.14
R2075 T7006 T6961 nsubj p,0.14
R2076 T7007 T6961 punct =,0.14
R2077 T7008 T6961 punct ],0.14
R2078 T7009 T7010 punct (,3B
R2079 T7010 T6938 parataxis 3B,improved
R2080 T7011 T7010 compound Figs.,3B
R2081 T7012 T7010 punct ", ",3B
R2082 T7013 T7010 conj 3C,3B
R2083 T7014 T7013 cc and,3C
R2084 T7015 T7013 conj 3D,3C
R2085 T7016 T7010 punct ),3B
R2086 T7017 T6938 punct .,improved
R2087 T7019 T7020 prep In,showed
R2088 T7021 T7022 det a,test
R2089 T7022 T7019 pobj test,In
R2090 T7023 T7022 compound traction,test
R2091 T7024 T7020 punct ", ",showed
R2092 T7025 T7026 punct (,mice
R2094 T7027 T7028 punct -,-
R2095 T7028 T7026 punct -,mice
R2096 T7029 T7028 punct /,-
R2097 T7030 T7026 punct ),mice
R2098 T7031 T7032 det a,strength
R2099 T7032 T7020 dobj strength,showed
R2100 T7033 T7032 amod high,strength
R2101 T7034 T7032 compound grip,strength
R2102 T7035 T7032 amod similar,strength
R2103 T7036 T7035 prep to,similar
R2104 T7037 T7036 pobj that,to
R2105 T7038 T7037 prep of,that
R2106 T7039 T7040 punct (,mice
R2107 T7040 T7038 pobj mice,of
R2108 T7041 T7042 punct +,+
R2109 T7042 T7040 punct +,mice
R2110 T7043 T7042 punct /,+
R2111 T7044 T7042 punct ),+
R2112 T7045 T7042 cc and,+
R2113 T7046 T7047 punct (,-
R2114 T7047 T7042 conj -,+
R2115 T7048 T7047 punct +,-
R2116 T7049 T7047 punct /,-
R2117 T7050 T7040 punct ),mice
R2118 T7051 T7052 punct (,Fig.
R2119 T7052 T7020 parataxis Fig.,showed
R2120 T7053 T7052 nummod 4,Fig.
R2121 T7054 T7052 punct ),Fig.
R2122 T7055 T7020 punct .,showed
R2123 T7057 T7058 det The,score
R2124 T7058 T7060 nsubj score,were
R2125 T7059 T7058 amod hanging,score
R2126 T7061 T7058 cc and,score
R2127 T7062 T7058 conj time,score
R2128 T7063 T7058 prep of,score
R2129 T7064 T7065 punct (,mice
R2131 T7066 T7067 punct -,-
R2132 T7067 T7065 punct -,mice
R2133 T7068 T7067 punct /,-
R2134 T7069 T7065 punct ),mice
R2135 T7070 T7060 advmod also,were
R2136 T7071 T7060 acomp similar,were
R2137 T7072 T7071 prep to,similar
R2138 T7073 T7072 pobj those,to
R2139 T7074 T7073 prep of,those
R2140 T7075 T7076 punct (,mice
R2141 T7076 T7074 pobj mice,of
R2142 T7077 T7078 punct +,+
R2143 T7078 T7076 punct +,mice
R2144 T7079 T7078 punct /,+
R2145 T7080 T7078 punct ),+
R2146 T7081 T7078 cc and,+
R2147 T7082 T7083 punct (,-
R2148 T7083 T7078 conj -,+
R2149 T7084 T7083 punct +,-
R2150 T7085 T7083 punct /,-
R2151 T7086 T7076 punct ),mice
R2152 T7087 T7088 punct (,5A
R2153 T7088 T7060 parataxis 5A,were
R2154 T7089 T7088 compound Figs.,5A
R2155 T7090 T7088 cc and,5A
R2156 T7091 T7088 conj 5B,5A
R2157 T7092 T7088 punct ),5A
R2158 T7093 T7060 punct .,were
R2159 T7095 T7096 det A,test
R2160 T7096 T7098 nsubj test,reveal
R2161 T7097 T7096 compound footprint,test
R2162 T7099 T7098 aux did,reveal
R2163 T7100 T7098 neg not,reveal
R2164 T7101 T7102 det any,abnormalities
R2165 T7102 T7098 dobj abnormalities,reveal
R2166 T7103 T7102 prep in,abnormalities
R2167 T7104 T7105 amod walking,patterns
R2168 T7105 T7103 pobj patterns,in
R2169 T7106 T7102 punct ", ",abnormalities
R2170 T7107 T7102 prep including,abnormalities
R2171 T7108 T7109 compound stride,length
R2172 T7109 T7107 pobj length,including
R2173 T7110 T7109 cc and,length
R2174 T7111 T7112 compound step,width
R2175 T7112 T7109 conj width,length
R2176 T7113 T7098 punct ", ",reveal
R2177 T7114 T7098 prep as,reveal
R2178 T7115 T7116 det a,function
R2179 T7116 T7114 pobj function,as
R2180 T7117 T7116 prep of,function
R2181 T7118 T7117 pobj genotypes,of
R2182 T7119 T7120 punct (,6A
R2183 T7120 T7098 parataxis 6A,reveal
R2184 T7121 T7120 compound Figs.,6A
R2185 T7122 T7120 cc and,6A
R2186 T7123 T7120 conj 6B,6A
R2187 T7124 T7120 punct ),6A
R2188 T7125 T7098 punct .,reveal
R2199 T9981 T9982 prep In,examined
R2200 T9983 T9984 det the,study
R2201 T9984 T9981 pobj study,In
R2202 T9985 T9984 amod present,study
R2203 T9986 T9982 punct ", ",examined
R2204 T9987 T9982 nsubj we,examined
R2205 T9988 T9989 det the,function
R2206 T9989 T9982 dobj function,examined
R2207 T9990 T9989 prep of,function
R2208 T9991 T9990 pobj ADAM11,of
R2209 T9992 T9982 prep by,examined
R2210 T9993 T9992 pcomp generating,by
R2211 T9994 T9993 dobj mice,generating
R2212 T9995 T9996 dep that,lacked
R2213 T9996 T9994 relcl lacked,mice
R2214 T9997 T9998 det the,gene
R2215 T9998 T9996 dobj gene,lacked
R2216 T9999 T9998 compound Adam11,gene
R2217 T10000 T9982 punct .,examined
R2218 T10002 T10003 nsubjpass It,reported
R2219 T10004 T10003 aux has,reported
R2220 T10005 T10003 auxpass been,reported
R2221 T10006 T10007 mark that,expressed
R2222 T10007 T10003 ccomp expressed,reported
R2223 T10008 T10009 det the,gene
R2224 T10009 T10007 nsubjpass gene,expressed
R2225 T10010 T10009 compound Adam11,gene
R2226 T10011 T10007 auxpass is,expressed
R2227 T10012 T10007 prep in,expressed
R2228 T10013 T10014 det the,brain
R2229 T10014 T10012 pobj brain,in
R2230 T10015 T10014 punct ", ",brain
R2231 T10016 T10014 conj heart,brain
R2232 T10017 T10016 punct ", ",heart
R2233 T10018 T10016 conj liver,heart
R2234 T10019 T10018 cc and,liver
R2235 T10020 T10018 conj testis,liver
R2236 T10021 T10007 punct ", ",expressed
R2237 T10022 T10023 mark as,manifested
R2238 T10023 T10007 advcl manifested,expressed
R2239 T10024 T10023 prep in,manifested
R2240 T10025 T10026 compound Northern,blot
R2241 T10026 T10027 compound blot,analysis
R2242 T10027 T10024 pobj analysis,in
R2243 T10028 T10029 punct [,19
R2244 T10029 T10003 parataxis 19,reported
R2245 T10030 T10029 punct ],19
R2246 T10031 T10003 punct .,reported
R2247 T10033 T10034 advmod Interestingly,appeared
R2248 T10035 T10034 punct ", ",appeared
R2249 T10036 T10037 npadvmod ADAM11,deficient
R2250 T10037 T10039 amod deficient,mice
R2251 T10038 T10037 punct -,deficient
R2252 T10039 T10034 nsubj mice,appeared
R2253 T10040 T10034 oprd normal,appeared
R2254 T10041 T10034 cc and,appeared
R2255 T10042 T10034 conj survived,appeared
R2256 T10043 T10044 amod more,one
R2257 T10044 T10046 nummod one,year
R2258 T10045 T10044 quantmod than,one
R2259 T10046 T10042 npadvmod year,survived
R2260 T10047 T10042 prep without,survived
R2261 T10048 T10049 amod apparent,abnormality
R2262 T10049 T10047 pobj abnormality,without
R2263 T10050 T10049 amod histological,abnormality
R2264 T10051 T10049 punct ", ",abnormality
R2265 T10052 T10049 prep including,abnormality
R2266 T10053 T10054 det the,brain
R2267 T10054 T10052 pobj brain,including
R2268 T10055 T10054 punct ", ",brain
R2269 T10105 T10104 pcomp examining,on
R2270 T10056 T10054 conj heart,brain
R2271 T10057 T10056 punct ", ",heart
R2272 T10106 T10107 det the,tests
R2273 T10107 T10105 dobj tests,examining
R2274 T10108 T10109 npadvmod hippocampus,dependent
R2275 T10058 T10056 conj liver,heart
R2276 T10109 T10107 amod dependent,tests
R2277 T10110 T10108 punct -,hippocampus
R2278 T10059 T10058 cc and,liver
R2279 T10111 T10108 cc and,hippocampus
R2280 T10112 T10108 conj cerebellum,hippocampus
R2281 T10113 T10109 punct -,dependent
R2282 T10060 T10058 conj testis,liver
R2283 T10114 T10107 amod behavioural,tests
R2284 T10115 T10116 aux to,study
R2285 T10061 T10034 punct .,appeared
R2286 T10116 T10102 advcl study,focused
R2287 T10117 T10118 det the,functions
R2288 T10118 T10116 dobj functions,study
R2289 T10063 T10064 det The,patterns
R2290 T10119 T10118 prep of,functions
R2291 T10064 T10066 nsubjpass patterns,studied
R2292 T10120 T10119 pobj ADAM11,of
R2293 T10121 T10118 prep in,functions
R2294 T10122 T10123 det the,system
R2295 T10123 T10121 pobj system,in
R2296 T10124 T10123 amod nervous,system
R2297 T10065 T10064 compound expression,patterns
R2298 T10125 T10102 punct .,focused
R2299 T10067 T10064 prep of,patterns
R2300 T10127 T10128 nsubjpass It,accepted
R2301 T10129 T10128 auxpass is,accepted
R2302 T10130 T10128 advmod widely,accepted
R2303 T10068 T10069 det the,gene
R2304 T10131 T10132 mark that,involved
R2305 T10132 T10128 ccomp involved,accepted
R2306 T10069 T10067 pobj gene,of
R2307 T10133 T10134 det the,hippocampus
R2308 T10134 T10132 nsubjpass hippocampus,involved
R2309 T10135 T10132 auxpass is,involved
R2310 T10070 T10069 compound Adam11,gene
R2311 T10136 T10132 prep in,involved
R2312 T10071 T10064 prep in,patterns
R2313 T10137 T10138 det the,performance
R2314 T10138 T10136 pobj performance,in
R2315 T10139 T10138 prep of,performance
R2316 T10140 T10141 det the,version
R2317 T10141 T10139 pobj version,of
R2318 T10072 T10073 det the,brain
R2319 T10142 T10143 amod hidden,platform
R2320 T10143 T10141 compound platform,version
R2321 T10144 T10141 prep of,version
R2322 T10073 T10071 pobj brain,in
R2323 T10145 T10146 det the,test
R2324 T10146 T10144 pobj test,of
R2325 T10147 T10148 compound water,maze
R2326 T10074 T10066 aux have,studied
R2327 T10148 T10146 compound maze,test
R2328 T10149 T10128 punct ", ",accepted
R2329 T10150 T10151 mark since,lead
R2330 T10075 T10066 auxpass been,studied
R2331 T10151 T10128 advcl lead,accepted
R2332 T10152 T10151 nsubj lesions,lead
R2333 T10153 T10152 prep of,lesions
R2334 T10076 T10066 advcl using,studied
R2335 T10154 T10155 det the,pathways
R2336 T10155 T10153 pobj pathways,of
R2337 T10156 T10155 amod hippocampal,pathways
R2338 T10077 T10078 advmod in,situ
R2339 T10157 T10151 prep to,lead
R2340 T10158 T10159 det a,impairment
R2341 T10159 T10157 pobj impairment,to
R2342 T10078 T10079 amod situ,hybridisation
R2343 T10160 T10159 amod severe,impairment
R2344 T10161 T10159 prep of,impairment
R2345 T10162 T10161 pobj learning,of
R2346 T10163 T10151 prep in,lead
R2347 T10164 T10165 det this,task
R2348 T10165 T10163 pobj task,in
R2349 T10079 T10076 dobj hybridisation,using
R2350 T10166 T10167 punct [,29
R2351 T10167 T10151 parataxis 29,lead
R2352 T10168 T10167 punct ],29
R2353 T10080 T10081 punct [,25
R2354 T10169 T10128 punct .,accepted
R2355 T10171 T10172 prep In,needed
R2356 T10081 T10066 parataxis 25,studied
R2357 T10173 T10174 det the,task
R2358 T10174 T10171 pobj task,In
R2359 T10082 T10081 punct ],25
R2360 T10175 T10176 amod hidden,platform
R2361 T10176 T10174 compound platform,task
R2362 T10177 T10172 punct ", ",needed
R2363 T10083 T10066 punct .,studied
R2364 T10178 T10179 npadvmod ADAM11,deficient
R2365 T10179 T10181 amod deficient,mice
R2366 T10180 T10179 punct -,deficient
R2367 T10085 T10086 det This,study
R2368 T10181 T10172 nsubj mice,needed
R2369 T10182 T10183 amod more,time
R2370 T10183 T10172 dobj time,needed
R2371 T10184 T10185 aux to,reach
R2372 T10086 T10087 nsubj study,shown
R2373 T10185 T10183 advcl reach,time
R2374 T10186 T10187 det the,platform
R2375 T10187 T10185 dobj platform,reach
R2376 T10088 T10087 aux has,shown
R2379 T10190 T10192 compound type,mice
R2380 T10191 T10190 punct -,type
R2381 T10089 T10090 amod high,expression
R2382 T10192 T10188 pobj mice,than
R2383 T10193 T10172 punct .,needed
R2384 T10090 T10087 dobj expression,shown
R2385 T10195 T10196 amod Spatial,learning
R2386 T10196 T10197 nsubjpass learning,assessed
R2387 T10091 T10090 prep of,expression
R2388 T10198 T10197 auxpass was,assessed
R2389 T10199 T10197 advmod also,assessed
R2390 T10200 T10197 advcl using,assessed
R2391 T10092 T10093 compound ADAM11,mRNA
R2392 T10201 T10202 det a,trial
R2393 T10202 T10200 dobj trial,using
R2394 T10203 T10202 compound probe,trial
R2395 T10093 T10091 pobj mRNA,of
R2396 T10204 T10202 punct ", ",trial
R2397 T10205 T10206 prep in,removed
R2398 T10206 T10202 relcl removed,trial
R2399 T10094 T10090 prep in,expression
R2400 T10207 T10205 pobj which,in
R2401 T10208 T10209 det the,platform
R2402 T10209 T10206 nsubjpass platform,removed
R2403 T10095 T10096 det the,hippocampus
R2404 T10210 T10206 auxpass was,removed
R2405 T10096 T10094 pobj hippocampus,in
R2406 T10097 T10096 cc and,hippocampus
R2407 T10098 T10096 conj cerebellum,hippocampus
R2408 T10099 T10087 punct .,shown
R2409 T10211 T10206 prep from,removed
R2410 T10212 T10213 det the,pool
R2411 T10213 T10211 pobj pool,from
R2412 T10101 T10102 nsubj We,focused
R2413 T10214 T10206 prep on,removed
R2414 T10215 T10216 det the,day
R2415 T10216 T10214 pobj day,on
R2416 T10103 T10102 advmod therefore,focused
R2417 T10217 T10216 prep following,day
R2418 T10218 T10219 nummod nine,days
R2419 T10104 T10102 prep on,focused
R2420 T10219 T10217 pobj days,following
R2421 T10220 T10219 prep of,days
R2422 T10221 T10220 pobj training,of
R2423 T10222 T10197 punct .,assessed
R2424 T10317 T10318 det the,coordination
R2425 T10224 T10225 det The,mice
R2426 T10225 T10229 nsubj mice,spent
R2427 T10318 T10316 pobj coordination,of
R2428 T10226 T10227 amod wild,type
R2429 T10227 T10225 compound type,mice
R2430 T10228 T10227 punct -,type
R2431 T10319 T10318 amod smooth,coordination
R2432 T10230 T10231 advmod significantly,more
R2433 T10231 T10232 amod more,time
R2434 T10320 T10318 prep of,coordination
R2435 T10232 T10229 dobj time,spent
R2436 T10233 T10229 xcomp searching,spent
R2437 T10321 T10322 amod somatic,activity
R2438 T10234 T10233 prep for,searching
R2439 T10235 T10236 det the,platform
R2440 T10236 T10234 pobj platform,for
R2441 T10322 T10320 pobj activity,of
R2442 T10237 T10233 prep in,searching
R2443 T10238 T10239 det the,quadrant
R2444 T10239 T10237 pobj quadrant,in
R2445 T10323 T10322 compound motor,activity
R2446 T10240 T10239 compound target,quadrant
R2447 T10241 T10229 prep than,spent
R2448 T10242 T10243 det the,quadrants
R2449 T10243 T10241 pobj quadrants,than
R2450 T10244 T10243 amod other,quadrants
R2451 T10245 T10229 punct .,spent
R2452 T10324 T10318 punct ", ",coordination
R2453 T10247 T10248 advmod However,search
R2454 T10325 T10318 conj regulation,coordination
R2455 T10249 T10248 punct ", ",search
R2456 T10250 T10251 npadvmod ADAM11,deficient
R2457 T10326 T10325 prep of,regulation
R2458 T10251 T10253 amod deficient,mice
R2459 T10252 T10251 punct -,deficient
R2460 T10253 T10248 nsubj mice,search
R2461 T10327 T10328 compound muscle,tone
R2462 T10254 T10248 aux did,search
R2463 T10255 T10248 neg not,search
R2464 T10256 T10248 advmod selectively,search
R2465 T10328 T10326 pobj tone,of
R2466 T10257 T10248 prep in,search
R2467 T10258 T10259 det the,quadrant
R2468 T10259 T10257 pobj quadrant,in
R2469 T10329 T10325 punct ", ",regulation
R2470 T10260 T10259 compound target,quadrant
R2471 T10261 T10248 punct .,search
R2472 T10330 T10325 cc and,regulation
R2473 T10263 T10264 prep On,were
R2474 T10331 T10325 conj mechanisms,regulation
R2475 T10265 T10266 det the,hand
R2476 T10266 T10263 pobj hand,On
R2477 T10332 T10333 dep that,influence
R2478 T10267 T10266 amod other,hand
R2479 T10268 T10264 punct ", ",were
R2480 T10269 T10264 prep in,were
R2481 T10333 T10331 relcl influence,mechanisms
R2482 T10270 T10271 det the,version
R2483 T10271 T10269 pobj version,in
R2484 T10272 T10273 amod visible,platform
R2485 T10334 T10333 cc and,influence
R2486 T10273 T10271 compound platform,version
R2487 T10274 T10271 punct ", ",version
R2488 T10275 T10276 prep in,tested
R2489 T10335 T10333 conj maintain,influence
R2490 T10276 T10271 relcl tested,version
R2491 T10277 T10275 pobj which,in
R2492 T10278 T10279 det the,ability
R2493 T10336 T10335 dobj equilibrium,maintain
R2494 T10279 T10276 nsubjpass ability,tested
R2495 T10280 T10279 amod motor,ability
R2496 T10281 T10279 cc and,ability
R2497 T10337 T10338 punct [,30
R2498 T10282 T10283 amod visual,acuity
R2499 T10283 T10279 conj acuity,ability
R2500 T10284 T10279 prep of,ability
R2501 T10285 T10286 det the,mouse
R2502 T10286 T10284 pobj mouse,of
R2503 T10287 T10276 auxpass are,tested
R2504 T10288 T10264 punct ", ",were
R2505 T10338 T10313 parataxis 30,is
R2506 T10289 T10290 npadvmod ADAM11,defieient
R2507 T10290 T10292 amod defieient,mice
R2508 T10291 T10290 punct -,defieient
R2509 T10339 T10338 punct ],30
R2510 T10292 T10264 nsubj mice,were
R2511 T10293 T10264 acomp normal,were
R2512 T10340 T10313 punct .,is
R2513 T10342 T10343 nsubjpass It,accepted
R2514 T10294 T10264 punct .,were
R2515 T10344 T10343 auxpass is,accepted
R2516 T10296 T10297 det These,results
R2517 T10297 T10298 nsubj results,indicated
R2518 T10299 T10300 mark that,showed
R2519 T10345 T10343 advmod widely,accepted
R2520 T10300 T10298 ccomp showed,indicated
R2521 T10301 T10302 npadvmod ADAM11,deficient
R2522 T10302 T10304 amod deficient,mice
R2523 T10346 T10347 mark that,involved
R2524 T10303 T10302 punct -,deficient
R2525 T10304 T10300 nsubj mice,showed
R2526 T10347 T10343 ccomp involved,accepted
R2527 T10305 T10306 det a,impairment
R2528 T10348 T10349 det the,cerebellum
R2529 T10306 T10300 dobj impairment,showed
R2530 T10307 T10308 amod spatial,learning
R2531 T10308 T10306 compound learning,impairment
R2532 T10349 T10347 nsubjpass cerebellum,involved
R2533 T10309 T10298 punct .,indicated
R2534 T10311 T10312 det The,cerebellum
R2535 T10350 T10347 auxpass is,involved
R2536 T10312 T10313 nsubj cerebellum,is
R2537 T10351 T10347 prep in,involved
R2538 T10314 T10313 prep in,is
R2539 T10315 T10314 pobj charge,in
R2540 T10316 T10315 prep of,charge
R2541 T10352 T10353 det the,performance
R2542 T10353 T10351 pobj performance,in
R2543 T10354 T10353 prep of,performance
R2544 T10355 T10356 det the,task
R2545 T10423 T10421 pobj rpm,at
R2546 T10356 T10354 pobj task,of
R2547 T10424 T10425 punct (,stationary
R2548 T10425 T10423 parataxis stationary,rpm
R2549 T10357 T10358 amod rotating,rod
R2550 T10426 T10425 punct ),stationary
R2551 T10427 T10392 punct ", ",fell
R2552 T10358 T10356 compound rod,task
R2553 T10428 T10429 npadvmod ADAM11,deficient
R2554 T10429 T10431 amod deficient,mice
R2555 T10430 T10429 punct -,deficient
R2556 T10431 T10392 nsubj mice,fell
R2557 T10432 T10433 advmod more,quickly
R2558 T10433 T10392 advmod quickly,fell
R2559 T10359 T10343 punct ", ",accepted
R2560 T10434 T10392 prep from,fell
R2561 T10435 T10436 det the,rod
R2562 T10436 T10434 pobj rod,from
R2563 T10360 T10361 mark since,exhibit
R2564 T10437 T10392 prep than,fell
R2565 T10438 T10439 amod wild,type
R2566 T10439 T10441 compound type,mice
R2567 T10361 T10343 advcl exhibit,accepted
R2568 T10440 T10439 punct -,type
R2569 T10441 T10437 pobj mice,than
R2570 T10442 T10392 prep at,fell
R2571 T10362 T10361 nsubj mice,exhibit
R2572 T10443 T10444 nummod 5,rpm
R2573 T10444 T10442 pobj rpm,at
R2574 T10445 T10443 punct ", ",5
R2575 T10363 T10362 prep with,mice
R2576 T10446 T10443 conj 10,5
R2577 T10447 T10446 cc and,10
R2578 T10448 T10446 conj 15,10
R2579 T10364 T10365 amod structural,abnormalities
R2580 T10449 T10392 punct .,fell
R2581 T10451 T10452 det These,results
R2582 T10365 T10363 pobj abnormalities,with
R2583 T10452 T10453 nsubj results,indicate
R2584 T10454 T10455 mark that,have
R2585 T10366 T10365 prep in,abnormalities
R2586 T10455 T10453 ccomp have,indicate
R2587 T10456 T10457 npadvmod ADAM11,deficient
R2588 T10367 T10368 det the,cerebellum
R2589 T10457 T10459 amod deficient,mice
R2590 T10458 T10457 punct -,deficient
R2591 T10459 T10455 nsubj mice,have
R2592 T10368 T10366 pobj cerebellum,in
R2593 T10460 T10461 det a,deficit
R2594 T10461 T10455 dobj deficit,have
R2595 T10462 T10461 prep in,deficit
R2596 T10369 T10370 punct [,31
R2597 T10463 T10464 compound motor,coordination
R2598 T10464 T10462 pobj coordination,in
R2599 T10465 T10453 punct .,indicate
R2600 T10370 T10365 parataxis 31,abnormalities
R2601 T10371 T10370 punct ],31
R2602 T10467 T10468 prep On,was
R2603 T10372 T10363 cc or,with
R2604 T10469 T10470 det the,hand
R2605 T10470 T10467 pobj hand,On
R2606 T10471 T10470 amod other,hand
R2607 T10472 T10468 punct ", ",was
R2608 T10473 T10468 prep in,was
R2609 T10474 T10475 det the,version
R2610 T10373 T10363 conj with,with
R2611 T10475 T10473 pobj version,in
R2612 T10476 T10477 amod visual,platform
R2613 T10374 T10373 pobj disruptions,with
R2614 T10477 T10475 compound platform,version
R2615 T10478 T10475 prep of,version
R2616 T10479 T10480 det the,task
R2617 T10375 T10374 prep in,disruptions
R2618 T10480 T10478 pobj task,of
R2619 T10481 T10482 compound water,maze
R2620 T10482 T10480 compound maze,task
R2621 T10376 T10375 pobj genes,in
R2622 T10483 T10468 punct ", ",was
R2623 T10484 T10485 compound motor,ability
R2624 T10485 T10468 nsubj ability,was
R2625 T10377 T10376 acl enriched,genes
R2626 T10486 T10485 prep for,ability
R2627 T10487 T10486 pobj swimming,for
R2628 T10488 T10485 prep in,ability
R2629 T10378 T10377 prep in,enriched
R2630 T10489 T10490 npadvmod ADAM11,deficient
R2631 T10490 T10492 amod deficient,mice
R2632 T10491 T10490 punct -,deficient
R2633 T10379 T10380 det the,cerebellum
R2634 T10492 T10488 pobj mice,in
R2635 T10493 T10468 acomp normal,was
R2636 T10494 T10468 punct .,was
R2637 T10380 T10378 pobj cerebellum,in
R2638 T10496 T10497 det These,results
R2639 T10497 T10498 nsubj results,suggested
R2640 T10381 T10382 punct [,32
R2641 T10382 T10374 parataxis 32,disruptions
R2642 T10499 T10500 mark that,be
R2643 T10500 T10498 ccomp be,suggested
R2644 T10501 T10500 expl there,be
R2645 T10502 T10500 aux might,be
R2646 T10383 T10382 punct ],32
R2647 T10503 T10504 det a,mechanism
R2648 T10504 T10500 attr mechanism,be
R2649 T10505 T10504 amod different,mechanism
R2650 T10384 T10385 compound performance,deficits
R2651 T10506 T10504 prep of,mechanism
R2652 T10507 T10508 compound motor,function
R2653 T10508 T10506 pobj function,of
R2654 T10385 T10361 dobj deficits,exhibit
R2655 T10509 T10504 prep between,mechanism
R2656 T10510 T10509 pobj swimming,between
R2657 T10511 T10510 cc and,swimming
R2658 T10512 T10513 det the,task
R2659 T10513 T10510 conj task,swimming
R2660 T10514 T10515 amod rotating,rod
R2661 T10515 T10513 compound rod,task
R2662 T10386 T10361 prep in,exhibit
R2663 T10516 T10498 punct .,suggested
R2664 T10387 T10388 det this,task
R2665 T10518 T10519 nsubjpass It,reported
R2666 T10520 T10519 aux has,reported
R2667 T10388 T10386 pobj task,in
R2668 T10521 T10519 auxpass been,reported
R2669 T10522 T10519 advmod also,reported
R2670 T10523 T10524 mark that,involved
R2671 T10389 T10343 punct .,accepted
R2672 T10524 T10519 ccomp involved,reported
R2673 T10525 T10526 det the,cerebellum
R2674 T10391 T10392 prep In,fell
R2675 T10526 T10524 nsubjpass cerebellum,involved
R2676 T10527 T10524 auxpass is,involved
R2677 T10528 T10524 prep in,involved
R2678 T10393 T10394 det the,test
R2679 T10394 T10391 pobj test,In
R2680 T10529 T10530 det another,function
R2681 T10395 T10396 amod rotating,rod
R2682 T10530 T10528 pobj function,in
R2683 T10531 T10530 amod important,function
R2684 T10532 T10530 amod distinct,function
R2685 T10396 T10394 compound rod,test
R2686 T10533 T10530 punct : ,function
R2687 T10534 T10530 appos learning,function
R2688 T10397 T10394 prep in,test
R2689 T10535 T10534 acl associated,learning
R2690 T10536 T10535 prep with,associated
R2691 T10537 T10538 compound component,movement
R2692 T10398 T10399 det this,study
R2693 T10538 T10536 pobj movement,with
R2694 T10539 T10534 punct (,learning
R2695 T10399 T10397 pobj study,in
R2696 T10540 T10541 compound motor,learning
R2697 T10541 T10534 appos learning,learning
R2698 T10542 T10524 punct ),involved
R2699 T10400 T10392 punct ", ",fell
R2700 T10543 T10544 punct [,33
R2701 T10544 T10524 parataxis 33,involved
R2702 T10401 T10402 mark although,was
R2703 T10545 T10544 punct ],33
R2704 T10546 T10519 punct .,reported
R2705 T10402 T10392 advcl was,fell
R2706 T10548 T10549 det The,time
R2707 T10549 T10551 nsubj time,was
R2708 T10550 T10549 compound retention,time
R2709 T10403 T10404 det the,time
R2710 T10552 T10549 prep of,time
R2711 T10553 T10554 npadvmod synaptotagmin,deficient
R2712 T10404 T10402 nsubj time,was
R2713 T10554 T10560 amod deficient,mice
R2714 T10555 T10553 punct (,synaptotagmin
R2715 T10556 T10557 nmod Syt,IV
R2716 T10405 T10404 compound retention,time
R2717 T10557 T10553 appos IV,synaptotagmin
R2718 T10558 T10557 punct ),IV
R2719 T10559 T10554 punct -,deficient
R2720 T10406 T10404 prep of,time
R2721 T10560 T10552 pobj mice,of
R2722 T10561 T10549 prep on,time
R2723 T10562 T10563 det the,rod
R2724 T10407 T10408 npadvmod ADAM11,deficient
R2725 T10563 T10561 pobj rod,on
R2726 T10564 T10565 advmod significantly,shorter
R2727 T10408 T10410 amod deficient,mice
R2731 T10409 T10408 punct -,deficient
R2733 T10569 T10568 punct -,type
R2734 T10570 T10566 pobj mice,than
R2735 T10410 T10406 pobj mice,of
R2736 T10571 T10551 punct ", ",was
R2737 T10572 T10551 cc and,was
R2738 T10573 T10574 nsubj they,improved
R2739 T10411 T10404 prep on,time
R2740 T10574 T10551 conj improved,was
R2741 T10575 T10574 dobj it,improved
R2742 T10576 T10577 advmod approximately,to
R2743 T10412 T10413 det the,rod
R2744 T10577 T10574 prep to,improved
R2745 T10578 T10579 det the,rates
R2746 T10579 T10577 pobj rates,to
R2747 T10413 T10411 pobj rod,on
R2748 T10580 T10579 amod same,rates
R2749 T10414 T10402 neg not,was
R2750 T10581 T10582 mark as,did
R2751 T10582 T10574 advcl did,improved
R2752 T10583 T10584 amod wild,type
R2753 T10584 T10586 compound type,mice
R2754 T10415 T10402 acomp different,was
R2755 T10585 T10584 punct -,type
R2756 T10586 T10582 nsubj mice,did
R2757 T10587 T10574 prep during,improved
R2758 T10416 T10415 prep from,different
R2759 T10588 T10589 amod rotating,rod
R2760 T10589 T10590 compound rod,performance
R2761 T10590 T10587 pobj performance,during
R2762 T10591 T10592 punct [,34
R2763 T10592 T10574 parataxis 34,improved
R2764 T10593 T10592 punct ],34
R2765 T10594 T10574 punct .,improved
R2766 T10417 T10418 amod wild,type
R2767 T10596 T10597 det These,data
R2768 T10418 T10420 compound type,mice
R2769 T10597 T10598 nsubj data,suggest
R2770 T10599 T10600 det the,basis
R2771 T10600 T10601 nsubj basis,is
R2772 T10419 T10418 punct -,type
R2773 T10601 T10598 advcl is,suggest
R2774 T10602 T10600 prep for,basis
R2775 T10420 T10416 pobj mice,from
R2776 T10603 T10604 det the,deficit
R2777 T10604 T10602 pobj deficit,for
R2778 T10605 T10604 compound performance,deficit
R2779 T10421 T10402 prep at,was
R2780 T10606 T10604 prep on,deficit
R2781 T10607 T10608 det the,task
R2782 T10608 T10606 pobj task,on
R2783 T10422 T10423 nummod 0,rpm
R2784 T10609 T10610 amod rotating,rod
R2785 T10610 T10608 compound rod,task
R2786 T10611 T10604 prep in,deficit
R2787 T10612 T10613 det the,mutants
R2788 T10635 T10636 npadvmod ADAM11,deficient
R2789 T10613 T10611 pobj mutants,in
R2790 T10614 T10613 nmod Syt,mutants
R2791 T10615 T10614 nummod IV,Syt
R2792 T10636 T10638 amod deficient,mice
R2793 T10616 T10601 prep in,is
R2794 T10617 T10618 compound motor,coordination
R2795 T10618 T10616 pobj coordination,in
R2796 T10637 T10636 punct -,deficient
R2797 T10619 T10620 advmod rather,than
R2798 T10620 T10616 cc than,in
R2799 T10638 T10634 nsubj mice,improved
R2800 T10621 T10616 conj in,in
R2801 T10622 T10623 compound motor,learning
R2802 T10639 T10634 advmod slightly,improved
R2803 T10623 T10621 pobj learning,in
R2804 T10624 T10598 punct .,suggest
R2805 T10640 T10639 punct ", ",slightly
R2806 T10626 T10627 det The,results
R2807 T10627 T10628 nsubj results,showed
R2808 T10641 T10639 cc though,slightly
R2809 T10629 T10627 prep in,results
R2810 T10630 T10631 det the,study
R2811 T10631 T10629 pobj study,in
R2812 T10642 T10641 neg not,though
R2813 T10632 T10631 amod present,study
R2814 T10633 T10634 mark that,improved
R2815 T10643 T10639 conj significantly,slightly
R2816 T10634 T10628 ccomp improved,showed
R2817 T10644 T10634 punct ", ",improved
R2818 T10645 T10646 compound motor,learning
R2819 T10646 T10647 compound learning,ability
R2820 T10741 T10740 punct -,deficient
R2821 T10742 T10738 pobj mice,in
R2822 T10647 T10634 dobj ability,improved
R2823 T10743 T10727 punct .,was
R2824 T10648 T10634 prep during,improved
R2825 T10745 T10746 amod Spontaneous,activity
R2826 T10746 T10748 nsubjpass activity,found
R2827 T10747 T10746 compound motor,activity
R2828 T10649 T10650 amod rotating,rod
R2829 T10749 T10746 cc and,activity
R2830 T10750 T10751 amod walking,patterns
R2831 T10751 T10746 conj patterns,activity
R2832 T10650 T10651 compound rod,performance
R2833 T10752 T10746 prep of,activity
R2834 T10753 T10754 npadvmod ADAM11,deficient
R2835 T10754 T10756 amod deficient,mice
R2836 T10651 T10648 pobj performance,during
R2837 T10755 T10754 punct -,deficient
R2838 T10756 T10752 pobj mice,of
R2839 T10757 T10748 auxpass were,found
R2840 T10652 T10628 punct .,showed
R2841 T10758 T10748 advmod also,found
R2842 T10759 T10760 aux to,be
R2843 T10760 T10748 xcomp be,found
R2844 T10654 T10655 advmod However,was
R2845 T10761 T10760 acomp normal,be
R2846 T10762 T10760 punct ", ",be
R2847 T10763 T10760 advcl suggesting,be
R2848 T10764 T10765 mark that,derived
R2849 T10656 T10655 punct ", ",was
R2850 T10765 T10763 ccomp derived,suggesting
R2851 T10766 T10767 det the,dysfunction
R2852 T10767 T10765 nsubjpass dysfunction,derived
R2853 T10768 T10767 acl found,dysfunction
R2854 T10657 T10658 det the,deficit
R2855 T10769 T10768 prep in,found
R2856 T10770 T10771 det the,test
R2857 T10658 T10655 nsubj deficit,was
R2858 T10771 T10769 pobj test,in
R2859 T10772 T10773 amod rotating,rod
R2860 T10773 T10771 compound rod,test
R2861 T10659 T10658 prep of,deficit
R2862 T10774 T10765 auxpass was,derived
R2863 T10775 T10765 neg not,derived
R2864 T10776 T10765 prep from,derived
R2865 T10660 T10661 compound motor,learning
R2866 T10777 T10778 compound muscle,weakness
R2867 T10778 T10776 pobj weakness,from
R2868 T10779 T10778 cc or,weakness
R2869 T10780 T10781 amod other,disturbances
R2870 T10781 T10778 conj disturbances,weakness
R2871 T10782 T10781 amod peripheral,disturbances
R2872 T10661 T10659 pobj learning,of
R2873 T10783 T10748 punct .,found
R2874 T10785 T10786 det These,results
R2875 T10662 T10658 prep in,deficit
R2876 T10786 T10787 nsubj results,suggest
R2877 T10788 T10789 mark that,contribute
R2878 T10663 T10664 npadvmod ADAM11,deficient
R2879 T10789 T10787 ccomp contribute,suggest
R2880 T10790 T10791 amod limited,sites
R2881 T10664 T10666 amod deficient,mice
R2882 T10791 T10789 nsubj sites,contribute
R2883 T10792 T10791 compound brain,sites
R2884 T10793 T10791 punct ", ",sites
R2885 T10665 T10664 punct -,deficient
R2886 T10794 T10795 advmod mainly,hippocampus
R2887 T10795 T10791 appos hippocampus,sites
R2888 T10796 T10795 det the,hippocampus
R2889 T10666 T10662 pobj mice,in
R2890 T10797 T10795 cc and,hippocampus
R2891 T10798 T10795 conj cerebellum,hippocampus
R2892 T10799 T10789 punct ", ",contribute
R2893 T10667 T10655 neg not,was
R2894 T10800 T10789 aux might,contribute
R2895 T10801 T10789 prep to,contribute
R2896 T10802 T10803 det the,phenotype
R2897 T10668 T10655 acomp clear,was
R2898 T10803 T10801 pobj phenotype,to
R2899 T10804 T10803 amod dominant,phenotype
R2900 T10805 T10803 punct ", ",phenotype
R2901 T10669 T10655 prep in,was
R2902 T10806 T10807 amod spatial,learning
R2903 T10807 T10808 compound learning,impairment
R2904 T10808 T10803 appos impairment,phenotype
R2905 T10670 T10671 det this,study
R2906 T10809 T10808 cc and,impairment
R2907 T10810 T10811 compound motor,discoordination
R2908 T10811 T10808 conj discoordination,impairment
R2909 T10671 T10669 pobj study,in
R2910 T10812 T10789 prep in,contribute
R2911 T10813 T10814 npadvmod ADAM11,deficient
R2912 T10672 T10655 punct .,was
R2913 T10674 T10675 mark Because,ride
R2914 T10675 T10679 advcl ride,learn
R2915 T10814 T10816 amod deficient,mice
R2916 T10676 T10675 nsubj they,ride
R2917 T10815 T10814 punct -,deficient
R2918 T10816 T10812 pobj mice,in
R2919 T10817 T10787 punct .,suggest
R2920 T10677 T10675 aux could,ride
R2921 T10819 T10820 advmod In,situ
R2922 T10820 T10821 amod situ,hybridisation
R2923 T10821 T10822 compound hybridisation,analysis
R2924 T10678 T10675 neg not,ride
R2925 T10822 T10823 nsubj analysis,detected
R2926 T10824 T10823 aux has,detected
R2927 T10680 T10675 prep on,ride
R2928 T10825 T10826 compound Adam11,gene
R2929 T10826 T10827 compound gene,expression
R2930 T10827 T10823 dobj expression,detected
R2931 T10681 T10682 det the,rod
R2932 T10828 T10823 prep in,detected
R2933 T10829 T10830 det the,cells
R2934 T10682 T10680 pobj rod,on
R2935 T10830 T10828 pobj cells,in
R2936 T10831 T10830 amod pyramidal,cells
R2937 T10832 T10830 prep of,cells
R2938 T10683 T10682 amod rotating,rod
R2939 T10833 T10834 nmod CA1,fields
R2940 T10834 T10832 pobj fields,of
R2941 T10835 T10836 punct –,CA3
R2942 T10684 T10679 punct ", ",learn
R2943 T10836 T10833 prep CA3,CA1
R2944 T10837 T10830 cc and,cells
R2945 T10685 T10679 nsubj they,learn
R2946 T10838 T10839 compound granule,cells
R2947 T10839 T10830 conj cells,cells
R2948 T10840 T10839 prep of,cells
R2949 T10686 T10679 aux might,learn
R2950 T10841 T10842 det the,gyrus
R2951 T10842 T10840 pobj gyrus,of
R2952 T10843 T10842 compound dentate,gyrus
R2953 T10687 T10679 neg not,learn
R2954 T10844 T10842 prep in,gyrus
R2955 T10845 T10846 det the,hippocampus
R2956 T10846 T10844 pobj hippocampus,in
R2957 T10688 T10689 det this,task
R2958 T10689 T10679 dobj task,learn
R2959 T10690 T10679 punct .,learn
R2960 T10847 T10844 cc and,in
R2961 T10848 T10844 conj in,in
R2962 T10692 T10693 aux To,examine
R2963 T10849 T10850 amod granular,cells
R2964 T10850 T10848 pobj cells,in
R2965 T10851 T10850 prep in,cells
R2966 T10852 T10853 det the,cerebellum
R2967 T10693 T10694 advcl examine,need
R2968 T10853 T10851 pobj cerebellum,in
R2969 T10854 T10855 punct [,25
R2970 T10695 T10696 compound motor,learning
R2971 T10855 T10823 parataxis 25,detected
R2972 T10856 T10855 punct ],25
R2973 T10857 T10823 punct .,detected
R2974 T10859 T10860 nsubj It,is
R2975 T10860 T10861 ccomp is,observed
R2976 T10862 T10860 acomp unlikely,is
R2977 T10696 T10697 compound learning,ability
R2978 T10863 T10864 mark that,led
R2979 T10864 T10860 ccomp led,is
R2980 T10865 T10866 amod morphological,changes
R2981 T10697 T10693 dobj ability,examine
R2982 T10866 T10864 nsubj changes,led
R2983 T10867 T10866 prep during,changes
R2984 T10868 T10867 pobj development,during
R2985 T10698 T10693 prep in,examine
R2986 T10869 T10864 prep to,led
R2987 T10870 T10869 pobj impairment,to
R2988 T10871 T10870 prep of,impairment
R2989 T10699 T10700 npadvmod ADAM11,deficient
R2990 T10872 T10873 amod spatial,learning
R2991 T10873 T10871 pobj learning,of
R2992 T10874 T10873 cc and,learning
R2993 T10700 T10702 amod deficient,mice
R2994 T10875 T10876 compound motor,coordination
R2995 T10876 T10873 conj coordination,learning
R2996 T10877 T10861 punct ", ",observed
R2997 T10701 T10700 punct -,deficient
R2998 T10878 T10861 cc and,observed
R2999 T10879 T10880 amod morphological,alterations
R3000 T10880 T10861 nsubjpass alterations,observed
R3001 T10702 T10698 pobj mice,in
R3002 T10881 T10880 prep in,alterations
R3003 T10882 T10883 det the,cytoarchitecture
R3004 T10883 T10881 pobj cytoarchitecture,in
R3005 T10703 T10693 prep in,examine
R3006 T10884 T10883 prep of,cytoarchitecture
R3007 T10885 T10886 det the,hippocampus
R3008 T10886 T10884 pobj hippocampus,of
R3009 T10704 T10703 pobj detail,in
R3010 T10887 T10886 cc and,hippocampus
R3011 T10888 T10886 conj cerebellum,hippocampus
R3012 T10889 T10861 auxpass were,observed
R3013 T10705 T10694 punct ", ",need
R3014 T10890 T10861 neg not,observed
R3015 T10891 T10861 prep in,observed
R3016 T10892 T10893 npadvmod ADAM11,deficient
R3017 T10706 T10694 nsubj we,need
R3018 T10893 T10895 amod deficient,mice
R3019 T10894 T10893 punct -,deficient
R3020 T10895 T10891 pobj mice,in
R3021 T10707 T10694 aux will,need
R3022 T10896 T10861 prep after,observed
R3023 T10897 T10898 amod histological,investigation
R3024 T10898 T10896 pobj investigation,after
R3025 T10708 T10709 aux to,use
R3026 T10899 T10898 acl using,investigation
R3027 T10709 T10694 xcomp use,need
R3028 T10900 T10901 compound HE,staining
R3029 T10901 T10899 dobj staining,using
R3030 T10710 T10711 amod other,tasks
R3031 T10902 T10861 punct .,observed
R3032 T10904 T10905 advmod However,needed
R3033 T10711 T10709 dobj tasks,use
R3034 T10906 T10905 punct ", ",needed
R3035 T10712 T10713 amod cerebellar,dependent
R3036 T10907 T10908 mark because,thought
R3037 T10908 T10905 advcl thought,needed
R3038 T10909 T10908 nsubjpass it,thought
R3039 T10713 T10711 amod dependent,tasks
R3040 T10910 T10908 auxpass is,thought
R3041 T10911 T10912 mark that,plays
R3042 T10912 T10908 ccomp plays,thought
R3043 T10714 T10713 punct -,dependent
R3044 T10913 T10912 nsubj ADAM11,plays
R3045 T10914 T10915 det a,role
R3046 T10715 T10711 compound learning,tasks
R3047 T10915 T10912 dobj role,plays
R3048 T10916 T10912 prep in,plays
R3049 T10917 T10918 nmod neuron,neuron
R3050 T10716 T10711 punct ", ",tasks
R3051 T10918 T10920 nmod neuron,interactions
R3052 T10919 T10918 punct -,neuron
R3053 T10920 T10916 pobj interactions,in
R3054 T10921 T10918 cc or,neuron
R3055 T10717 T10718 amod such,as
R3056 T10922 T10923 nmod neuron,cell
R3057 T10923 T10918 conj cell,neuron
R3058 T10924 T10923 punct -,cell
R3059 T10718 T10711 prep as,tasks
R3060 T10925 T10923 amod glial,cell
R3061 T10926 T10905 punct ", ",needed
R3062 T10927 T10928 det a,investigation
R3063 T10719 T10720 det a,test
R3064 T10928 T10905 nsubjpass investigation,needed
R3065 T10929 T10930 advmod more,precise
R3066 T10930 T10928 amod precise,investigation
R3067 T10720 T10718 pobj test,as
R3068 T10931 T10928 amod morphological,investigation
R3069 T10932 T10905 aux will,needed
R3070 T10933 T10905 auxpass be,needed
R3071 T10721 T10720 amod classical,test
R3072 T10934 T10905 punct .,needed
R3073 T10936 T10937 nsubjpass It,reported
R3074 T10722 T10720 nmod eyelid,test
R3075 T10938 T10937 aux has,reported
R3076 T10939 T10937 auxpass been,reported
R3077 T10940 T10941 mark that,implicated
R3078 T10941 T10937 ccomp implicated,reported
R3079 T10723 T10722 amod conditioning,eyelid
R3083 T10724 T10694 punct .,need
R3084 T10945 T10946 amod such,as
R3085 T10946 T10943 prep as,molecules
R3086 T10947 T10948 amod neural,cell
R3087 T10726 T10727 expl There,was
R3088 T10948 T10949 compound cell,molecule
R3089 T10949 T10946 pobj molecule,as
R3090 T10950 T10949 compound adhesion,molecule
R3091 T10951 T10949 punct (,molecule
R3092 T10952 T10949 appos NCAM,molecule
R3093 T10728 T10729 det no,impairment
R3094 T10729 T10727 attr impairment,was
R3095 T10953 T10941 punct ),implicated
R3096 T10730 T10729 prep in,impairment
R3097 T10954 T10941 punct ", ",implicated
R3098 T10955 T10941 auxpass are,implicated
R3099 T10731 T10732 det the,test
R3100 T10956 T10941 preconj not,implicated
R3101 T10957 T10956 advmod only,not
R3102 T10958 T10941 prep in,implicated
R3103 T10732 T10730 pobj test,in
R3104 T10959 T10960 compound cell,interactions
R3105 T10960 T10958 pobj interactions,in
R3106 T10961 T10941 prep during,implicated
R3107 T10733 T10734 nmod grip,strength
R3108 T10962 T10963 amod nervous,system
R3109 T10963 T10964 compound system,development
R3110 T10964 T10961 pobj development,during
R3111 T10734 T10732 nmod strength,test
R3112 T10965 T10941 punct ", ",implicated
R3113 T10966 T10941 cc but,implicated
R3114 T10967 T10968 auxpass are,recognised
R3115 T10735 T10734 cc and,strength
R3116 T10968 T10941 conj recognised,implicated
R3117 T10969 T10968 advmod also,recognised
R3118 T10736 T10737 compound wire,suspension
R3119 T10970 T10968 prep as,recognised
R3120 T10971 T10972 amod important,mediators
R3121 T10972 T10970 pobj mediators,as
R3122 T10737 T10734 conj suspension,strength
R3123 T10973 T10972 prep of,mediators
R3124 T10974 T10975 amod synaptic,plasticity
R3125 T10975 T10973 pobj plasticity,of
R3126 T10738 T10727 prep in,was
R3127 T10976 T10968 prep in,recognised
R3128 T10977 T10978 det the,system
R3129 T10978 T10976 pobj system,in
R3130 T10979 T10978 amod adult,system
R3131 T10980 T10978 amod nervous,system
R3132 T10739 T10740 npadvmod ADAM11,deficient
R3133 T10981 T10982 punct [,35
R3134 T10982 T10968 parataxis 35,recognised
R3135 T10983 T10937 punct ],reported
R3136 T10740 T10742 amod deficient,mice
R3137 T11059 T11058 cc and,dysfunction
R3138 T10984 T10937 punct .,reported
R3139 T10986 T10987 nsubjpass Changes,thought
R3140 T11060 T11061 amod complete,loss
R3141 T10988 T10986 prep in,Changes
R3142 T10989 T10990 compound neuron,excitability
R3143 T11061 T11058 conj loss,dysfunction
R3144 T10990 T10988 pobj excitability,in
R3145 T10991 T10986 prep in,Changes
R3146 T10992 T10993 det the,hippocampus
R3147 T11062 T11061 prep of,loss
R3148 T10993 T10991 pobj hippocampus,in
R3149 T10994 T10986 punct ", ",Changes
R3150 T11063 T11064 preconj both,spontaneous
R3151 T10995 T10996 amod such,as
R3152 T10996 T10986 prep as,Changes
R3153 T11064 T11065 amod spontaneous,currents
R3154 T10997 T10996 pobj decreases,as
R3155 T10998 T10997 prep in,decreases
R3156 T10999 T11000 det the,post-burst
R3157 T11065 T11062 pobj currents,of
R3158 T11000 T10998 pobj post-burst,in
R3159 T11001 T10997 prep after,decreases
R3160 T11002 T11001 pobj hyperpolarization,after
R3161 T11003 T11004 punct (,AHP
R3162 T11004 T11002 parataxis AHP,hyperpolarization
R3163 T11005 T11004 punct ),AHP
R3164 T11066 T11064 cc and,spontaneous
R3165 T11006 T10987 punct ", ",thought
R3166 T11007 T10987 aux have,thought
R3167 T11008 T10987 auxpass been,thought
R3168 T11067 T11064 conj evoked,spontaneous
R3169 T11009 T11010 aux to,affect
R3170 T11010 T10987 xcomp affect,thought
R3171 T11068 T11065 amod excitatory,currents
R3172 T11011 T11012 amod long,term
R3173 T11012 T11014 compound term,potentiation
R3174 T11013 T11012 punct -,term
R3175 T11069 T11065 amod postsynaptic,currents
R3176 T11014 T11010 dobj potentiation,affect
R3177 T11015 T11014 punct (,potentiation
R3178 T11016 T11014 appos LTP,potentiation
R3179 T11070 T11065 punct (,currents
R3180 T11017 T11010 punct ),affect
R3181 T11018 T11019 punct [,36
R3182 T11019 T11010 parataxis 36,affect
R3183 T11020 T11019 punct ],36
R3184 T11021 T11010 punct ", ",affect
R3185 T11022 T11023 det an,model
R3186 T11071 T11065 appos EPSCs,currents
R3187 T11023 T11010 npadvmod model,affect
R3188 T11024 T11023 amod experimental,model
R3189 T11025 T11023 prep of,model
R3190 T11072 T11046 punct ),showed
R3191 T11026 T11027 det the,changes
R3192 T11027 T11025 pobj changes,of
R3193 T11028 T11027 amod synaptic,changes
R3194 T11073 T11046 prep in,showed
R3195 T11029 T11027 acl thought,changes
R3196 T11030 T11031 aux to,underlie
R3197 T11031 T11029 xcomp underlie,thought
R3198 T11074 T11075 amod cerebellar,cells
R3199 T11032 T11031 dobj learning,underlie
R3200 T11033 T11032 cc and,learning
R3201 T11034 T11032 conj memory,learning
R3202 T11075 T11073 pobj cells,in
R3203 T11035 T11036 punct [,37
R3204 T11036 T11029 parataxis 37,thought
R3205 T11037 T11036 punct ],37
R3206 T11076 T11075 compound granule,cells
R3207 T11038 T10987 punct .,thought
R3208 T11077 T11078 punct [,38
R3209 T11040 T11041 nsubjpass It,reported
R3210 T11042 T11041 aux has,reported
R3211 T11078 T11046 parataxis 38,showed
R3212 T11043 T11041 advmod also,reported
R3213 T11044 T11041 auxpass been,reported
R3214 T11045 T11046 mark that,showed
R3215 T11046 T11041 ccomp showed,reported
R3216 T11079 T11078 punct ],38
R3217 T11047 T11046 nsubj mice,showed
R3218 T11048 T11047 acl lacking,mice
R3219 T11049 T11050 compound NMDA,receptor
R3220 T11080 T11041 punct .,reported
R3221 T11050 T11048 dobj receptor,lacking
R3222 T11051 T11048 prep for,lacking
R3223 T11052 T11053 preconj both,subunits
R3224 T11082 T11083 advmod Therefore,needed
R3225 T11053 T11051 pobj subunits,for
R3226 T11054 T11053 nmod NR2A,subunits
R3227 T11055 T11054 cc and,NR2A
R3228 T11056 T11054 conj NR2C,NR2A
R3229 T11084 T11083 punct ", ",needed
R3230 T11057 T11058 compound motor,dysfunction
R3231 T11058 T11046 dobj dysfunction,showed
R3232 T11085 T11086 amod electrophyological,studies
R3233 T11086 T11083 nsubjpass studies,needed
R3234 T11087 T11088 aux to,enable
R3235 T11165 T11166 det the,hand
R3236 T11088 T11086 advcl enable,studies
R3237 T11166 T11163 pobj hand,On
R3238 T11167 T11166 amod other,hand
R3239 T11089 T11088 dobj analysis,enable
R3240 T11168 T11164 punct ", ",showed
R3241 T11169 T11164 nsubj mice,showed
R3242 T11090 T11089 prep of,analysis
R3243 T11170 T11169 acl lacking,mice
R3244 T11171 T11172 det the,gene
R3245 T11172 T11170 dobj gene,lacking
R3246 T11091 T11092 amod synaptic,transmission
R3247 T11173 T11172 compound Adam22,gene
R3248 T11174 T11175 amod severe,ataxia
R3249 T11175 T11164 dobj ataxia,showed
R3250 T11092 T11090 pobj transmission,of
R3251 T11176 T11164 punct ", ",showed
R3252 T11177 T11164 conj exhibited,showed
R3253 T11093 T11092 cc and,transmission
R3254 T11178 T11179 amod marked,hypomyelination
R3255 T11179 T11177 dobj hypomyelination,exhibited
R3256 T11180 T11179 prep of,hypomyelination
R3257 T11094 T11092 conj plasticity,transmission
R3258 T11181 T11182 det the,nerves
R3259 T11182 T11180 pobj nerves,of
R3260 T11183 T11182 amod peripheral,nerves
R3261 T11095 T11088 prep in,enable
R3262 T11184 T11177 punct ", ",exhibited
R3263 T11185 T11177 cc and,exhibited
R3264 T11186 T11177 conj died,exhibited
R3265 T11096 T11097 det the,hippocampus
R3266 T11187 T11186 prep before,died
R3267 T11188 T11187 pobj weaning,before
R3268 T11189 T11190 punct [,22
R3269 T11097 T11095 pobj hippocampus,in
R3270 T11190 T11186 parataxis 22,died
R3271 T11191 T11190 punct ],22
R3272 T11192 T11164 punct .,showed
R3273 T11098 T11097 cc and,hippocampus
R3274 T11194 T11195 nsubj Mice,showed
R3275 T11099 T11097 conj cerebellum,hippocampus
R3276 T11196 T11194 acl lacking,Mice
R3277 T11197 T11198 det the,gene
R3278 T11100 T11097 prep of,hippocampus
R3279 T11198 T11196 dobj gene,lacking
R3280 T11199 T11198 compound Adam23,gene
R3281 T11200 T11201 amod severe,ataxia
R3282 T11101 T11102 npadvmod ADAM11,deficient
R3283 T11201 T11195 dobj ataxia,showed
R3284 T11102 T11104 amod deficient,mice
R3285 T11202 T11201 cc and,ataxia
R3286 T11103 T11102 punct -,deficient
R3287 T11203 T11201 conj tremor,ataxia
R3288 T11204 T11195 cc and,showed
R3289 T11205 T11195 conj died,showed
R3290 T11104 T11100 pobj mice,of
R3291 T11206 T11205 prep before,died
R3292 T11207 T11206 pobj weaning,before
R3293 T11208 T11209 punct [,23
R3294 T11105 T11083 aux will,needed
R3295 T11209 T11205 parataxis 23,died
R3296 T11210 T11209 punct ],23
R3297 T11211 T11195 punct .,showed
R3298 T11106 T11083 auxpass be,needed
R3299 T11213 T11214 det These,findings
R3300 T11107 T11083 punct .,needed
R3301 T11214 T11215 nsubj findings,suggest
R3302 T11216 T11217 mark that,have
R3303 T11109 T11110 det These,studies
R3304 T11217 T11215 ccomp have,suggest
R3305 T11218 T11217 nsubj ADAM11,have
R3306 T11219 T11218 punct ", ",ADAM11
R3307 T11110 T11111 nsubj studies,clarify
R3308 T11220 T11218 conj ADAM22,ADAM11
R3309 T11221 T11220 cc and,ADAM22
R3310 T11222 T11220 conj ADAM23,ADAM22
R3311 T11112 T11111 aux might,clarify
R3312 T11223 T11224 amod separate,roles
R3313 T11224 T11217 dobj roles,have
R3314 T11225 T11223 cc and,separate
R3315 T11226 T11223 conj important,separate
R3316 T11113 T11114 mark whether,plays
R3317 T11227 T11224 prep in,roles
R3318 T11228 T11229 det the,system
R3319 T11229 T11227 pobj system,in
R3320 T11114 T11111 advcl plays,clarify
R3321 T11230 T11229 amod nervous,system
R3322 T11231 T11215 punct .,suggest
R3323 T11115 T11114 nsubj ADAM11,plays
R3324 T11233 T11234 det A,search
R3325 T11234 T11237 nsubj search,revealed
R3326 T11116 T11117 det an,role
R3327 T11235 T11234 compound genome,search
R3328 T11236 T11234 compound database,search
R3329 T11117 T11114 dobj role,plays
R3330 T11238 T11239 nsubj orthologs,exist
R3331 T11118 T11117 amod important,role
R3333 T11119 T11117 nmod signalling,role
R3334 T11240 T11238 prep of,orthologs
R3335 T11241 T11242 nmod ADAM11,genes
R3336 T11120 T11119 cc or,signalling
R3338 T11243 T11241 punct ", ",ADAM11
R3339 T11244 T11241 conj ADAM22,ADAM11
R3343 T11121 T11119 conj structural,signalling
R3346 T11122 T11114 prep at,plays
R3349 T11123 T11124 det the,level
R3353 T11124 T11122 pobj level,at
R3357 T11125 T11124 amod synaptic,level
R3361 T11126 T11114 cc and,plays
R3365 T11127 T11128 mark whether,participates
R3367 T11128 T11114 conj participates,plays
R3371 T11129 T11128 nsubj it,participates
R3374 T11130 T11128 prep in,participates
R3376 T11131 T11132 amod synaptic,regulation
R3379 T11132 T11130 pobj regulation,in
R3382 T11133 T11111 punct .,clarify
R3385 T11279 T11274 nsubj investigations,provide
R3386 T11135 T11136 npadvmod ADAM11,deficient
R3387 T11280 T11274 aux will,provide
R3388 T11281 T11274 dobj clues,provide
R3389 T11282 T11281 prep to,clues
R3390 T11283 T11282 pcomp understanding,to
R3391 T11284 T11285 det the,system
R3392 T11285 T11283 dobj system,understanding
R3393 T11286 T11285 amod nervous,system
R3394 T11136 T11138 amod deficient,mice
R3395 T11287 T11285 prep of,system
R3396 T11288 T11289 amod higher,organisms
R3397 T11289 T11287 pobj organisms,of
R3398 T11137 T11136 punct -,deficient
R3399 T11290 T11274 punct .,provide
R3400 T11138 T11139 nsubj mice,remained
R3401 T11140 T11139 acomp alive,remained
R3402 T11141 T11139 prep for,remained
R3403 T11142 T11143 amod more,one
R3404 T11143 T11145 nummod one,year
R3405 T11144 T11143 quantmod than,one
R3406 T11145 T11141 pobj year,for
R3407 T11146 T11139 prep without,remained
R3408 T11147 T11146 pobj ataxia,without
R3409 T11148 T11147 cc or,ataxia
R3410 T11149 T11147 conj tremor,ataxia
R3411 T11150 T11139 punct ", ",remained
R3412 T11151 T11139 cc but,remained
R3413 T11152 T11139 conj showed,remained
R3414 T11153 T11154 det a,deficit
R3415 T11154 T11152 dobj deficit,showed
R3416 T11155 T11154 prep in,deficit
R3417 T11156 T11157 amod spatial,learning
R3418 T11157 T11155 pobj learning,in
R3419 T11158 T11157 cc and,learning
R3420 T11159 T11160 compound motor,dysfunction
R3421 T11160 T11157 conj dysfunction,learning
R3422 T11161 T11139 punct .,remained
R3423 T11163 T11164 prep On,showed
R3424 T11498 T11499 npadvmod ADAM11,deficient
R3425 T11499 T11501 amod deficient,mice
R3426 T11500 T11499 punct -,deficient
R3427 T11501 T11502 nsubj mice,survived
R3428 T11503 T11504 amod more,one
R3429 T11504 T11506 nummod one,year
R3430 T11505 T11504 quantmod than,one
R3431 T11506 T11502 npadvmod year,survived
R3432 T11507 T11502 prep without,survived
R3433 T11508 T11507 pobj ataxia,without
R3434 T11509 T11508 cc or,ataxia
R3435 T11510 T11508 conj tremor,ataxia
R3436 T11511 T11502 punct ", ",survived
R3437 T11512 T11502 conj showed,survived
R3438 T11513 T11514 det no,abnormalities
R3439 T11514 T11512 dobj abnormalities,showed
R3440 T11515 T11514 prep in,abnormalities
R3441 T11516 T11517 compound body,weight
R3442 T11517 T11518 compound weight,gain
R3443 T11518 T11515 pobj gain,in
R3444 T11519 T11518 punct ", ",gain
R3445 T11520 T11521 amod spontaneous,activity
R3446 T11521 T11518 conj activity,gain
R3447 T11522 T11521 compound motor,activity
R3448 T11523 T11521 punct ", ",activity
R3449 T11524 T11525 compound muscle,strength
R3450 T11525 T11521 conj strength,activity
R3451 T11526 T11525 punct ", ",strength
R3452 T11527 T11525 cc or,strength
R3453 T11528 T11529 compound walking,patterns
R3454 T11529 T11525 conj patterns,strength
R3455 T11530 T11512 punct ", ",showed
R3456 T11531 T11512 cc and,showed
R3457 T11532 T11512 conj exhibited,showed
R3458 T11533 T11534 det no,changes
R3459 T11534 T11532 dobj changes,exhibited
R3460 T11535 T11534 amod apparent,changes
R3461 T11536 T11537 amod anatomical,histological
R3462 T11537 T11534 amod histological,changes
R3463 T11538 T11537 punct -,histological
R3464 T11539 T11502 punct .,survived
R3465 T11541 T11542 advmod However,impaired
R3466 T11543 T11542 punct ", ",impaired
R3467 T11544 T11545 npadvmod hippocampus,dependent
R3468 T11545 T11547 amod dependent,learning
R3469 T11546 T11545 punct -,dependent
R3470 T11547 T11542 nsubjpass learning,impaired
R3471 T11548 T11547 amod spatial,learning
R3472 T11549 T11547 cc and,learning
R3473 T11550 T11551 npadvmod cerebellum,dependent
R3474 T11551 T11553 amod dependent,coordination
R3475 T11552 T11551 punct -,dependent
R3476 T11553 T11547 conj coordination,learning
R3477 T11554 T11553 compound motor,coordination
R3478 T11555 T11547 prep in,learning
R3479 T11556 T11557 npadvmod ADAM11,deficient
R3480 T11557 T11559 amod deficient,mice
R3481 T11558 T11557 punct -,deficient
R3482 T11559 T11555 pobj mice,in
R3483 T11560 T11542 auxpass were,impaired
R3484 T11561 T11562 advmod when,tested
R3485 T11562 T11542 advcl tested,impaired
R3486 T11563 T11562 advcl using,tested
R3487 T11564 T11565 nmod water,maze
R3488 T11565 T11566 nmod maze,tasks
R3489 T11566 T11563 dobj tasks,using
R3490 T11567 T11565 cc and,maze
R3491 T11568 T11569 amod rotating,rod
R3492 T11569 T11565 conj rod,maze
R3493 T11570 T11542 punct .,impaired
R3494 T11572 T11573 poss Our,strain
R3495 T11573 T11577 nsubj strain,has
R3496 T11574 T11575 advmod genetically,modified
R3497 T11575 T11573 amod modified,strain
R3498 T11576 T11573 compound mouse,strain
R3499 T11578 T11579 det the,potential
R3500 T11579 T11577 dobj potential,has
R3501 T11580 T11581 aux to,be
R3502 T11581 T11579 acl be,potential
R3503 T11582 T11583 det a,tools
R3504 T11583 T11581 attr tools,be
R3505 T11584 T11583 amod useful,tools
R3506 T11585 T11584 cc and,useful
R3507 T11586 T11584 conj sensitive,useful
R3508 T11587 T11583 prep for,tools
R3509 T11588 T11589 amod detailed,investigation
R3510 T11589 T11587 pobj investigation,for
R3511 T11590 T11589 prep of,investigation
R3512 T11591 T11592 compound ADAM,proteins
R3513 T11592 T11593 poss proteins,functions
R3514 T11593 T11590 pobj functions,of
R3515 T11594 T11592 case ',proteins
R3516 T11595 T11593 prep in,functions
R3517 T11596 T11597 det the,system
R3518 T11597 T11595 pobj system,in
R3519 T11598 T11597 amod nervous,system
R3520 T11599 T11577 punct .,has
R3521 T11865 T11864 prep of,Construction
R3522 T11866 T11867 det an,vector
R3523 T11867 T11865 pobj vector,of
R3524 T11868 T11867 nmod Adam11,vector
R3525 T11869 T11867 nmod gene,vector
R3526 T11870 T11869 punct -,gene
R3527 T11871 T11869 amod targeting,gene
R3528 T11873 T11874 det The,fragment
R3529 T11874 T11880 nsubjpass fragment,amplified
R3530 T11875 T11876 nummod 13.7,kb
R3531 T11876 T11874 compound kb,fragment
R3532 T11877 T11876 punct -,kb
R3533 T11878 T11874 compound BamHI,fragment
R3534 T11879 T11874 compound DNA,fragment
R3535 T11881 T11874 acl covering,fragment
R3536 T11882 T11883 nmod exons,2
R3537 T11883 T11881 dobj 2,covering
R3538 T11884 T11885 punct –,20
R3539 T11885 T11883 prep 20,2
R3540 T11886 T11883 prep of,2
R3541 T11887 T11888 det the,gene
R3542 T11888 T11886 pobj gene,of
R3543 T11889 T11888 compound Adam11,gene
R3544 T11890 T11880 auxpass was,amplified
R3545 T11891 T11880 prep from,amplified
R3546 T11892 T11893 nmod C57BL,DNA
R3547 T11893 T11891 pobj DNA,from
R3548 T11894 T11892 punct /,C57BL
R3549 T11895 T11892 nummod 6,C57BL
R3550 T11896 T11893 amod genomic,DNA
R3551 T11897 T11880 prep by,amplified
R3552 T11898 T11899 det the,PCR
R3553 T11899 T11897 pobj PCR,by
R3554 T11900 T11899 acl using,PCR
R3555 T11901 T11902 compound Expand,mix
R3556 T11902 T11900 dobj mix,using
R3557 T11903 T11904 compound Hi,Fidelity
R3558 T11904 T11902 compound Fidelity,mix
R3559 T11905 T11904 punct -,Fidelity
R3560 T11906 T11902 compound polymerase,mix
R3561 T11907 T11908 punct (,KK
R3562 T11908 T11902 parataxis KK,mix
R3563 T11909 T11908 compound Roche,KK
R3564 T11910 T11908 compound Diagnostics,KK
R3565 T11911 T11908 punct ", ",KK
R3566 T11912 T11908 npadvmod Tokyo,KK
R3567 T11913 T11908 punct ", ",KK
R3568 T11914 T11908 npadvmod Japan,KK
R3569 T11915 T11908 punct ),KK
R3570 T11916 T11880 punct .,amplified
R3571 T11918 T11919 aux To,generate
R3572 T11919 T11920 advcl generate,inserted
R3573 T11921 T11922 det a,mutation
R3574 T11922 T11919 dobj mutation,generate
R3575 T11923 T11919 prep in,generate
R3576 T11924 T11925 det the,gene
R3577 T11925 T11923 pobj gene,in
R3578 T11926 T11925 compound mouse,gene
R3579 T11927 T11925 compound Adam11,gene
R3580 T11928 T11920 punct ", ",inserted
R3581 T11929 T11920 nsubj we,inserted
R3582 T11930 T11931 det a,cassette
R3583 T11931 T11920 dobj cassette,inserted
R3584 T11932 T11931 compound PGKneo,cassette
R3585 T11933 T11920 prep into,inserted
R3586 T11934 T11935 nmod exons,5
R3587 T11935 T11933 pobj 5,into
R3588 T11936 T11937 punct –,7
R3589 T11937 T11935 prep 7,5
R3590 T11938 T11935 prep of,5
R3591 T11939 T11940 det the,gene
R3592 T11940 T11938 pobj gene,of
R3593 T11941 T11940 compound Adam11,gene
R3594 T11942 T11920 punct .,inserted
R3595 T11944 T11945 det The,construct
R3596 T11945 T11948 nsubj construct,consisted
R3597 T11946 T11945 amod final,construct
R3598 T11947 T11945 compound targeting,construct
R3599 T11949 T11948 prep of,consisted
R3600 T11950 T11951 det a,fragment
R3601 T11951 T11949 pobj fragment,of
R3602 T11952 T11953 nummod 10.1,kb
R3603 T11953 T11951 nmod kb,fragment
R3604 T11954 T11953 punct -,kb
R3605 T11955 T11951 amod genomic,fragment
R3606 T11956 T11951 compound DNA,fragment
R3607 T11957 T11958 dep that,interrupted
R3608 T11958 T11951 relcl interrupted,fragment
R3609 T11959 T11958 auxpass was,interrupted
R3610 T11960 T11958 agent by,interrupted
R3611 T11961 T11962 det the,insertion
R3612 T11962 T11960 pobj insertion,by
R3613 T11963 T11962 prep of,insertion
R3614 T11964 T11965 det the,cassette
R3615 T11965 T11963 pobj cassette,of
R3616 T11966 T11965 compound PGKneo,cassette
R3617 T11967 T11958 cc and,interrupted
R3618 T11968 T11958 conj contained,interrupted
R3619 T11969 T11970 det a,cassette
R3620 T11970 T11968 dobj cassette,contained
R3621 T11971 T11972 compound MC1,TK
R3622 T11972 T11970 compound TK,cassette
R3623 T11973 T11972 punct /,TK
R3624 T11974 T11968 prep as,contained
R3625 T11975 T11976 det a,marker
R3626 T11976 T11974 pobj marker,as
R3627 T11977 T11978 amod negative,selection
R3628 T11978 T11976 compound selection,marker
R3629 T11979 T11976 prep against,marker
R3630 T11980 T11981 amod random,integration
R3631 T11981 T11979 pobj integration,against
R3632 T11982 T11983 punct [,39
R3633 T11983 T11968 parataxis 39,contained
R3634 T11984 T11983 punct ],39
R3635 T11985 T11948 punct .,consisted
R3640 T12310 T12309 prep of,Generation
R3641 T12311 T12312 npadvmod Adam11,deficient
R3642 T12312 T12313 amod deficient,mice
R3643 T12313 T12310 pobj mice,of
R3644 T12315 T12316 det The,vector
R3645 T12316 T12319 nsubjpass vector,electroporated
R3646 T12317 T12316 amod linearised,vector
R3647 T12318 T12316 compound targeting,vector
R3648 T12320 T12319 auxpass was,electroporated
R3649 T12321 T12319 prep into,electroporated
R3650 T12322 T12323 nmod TT2,cells
R3651 T12323 T12321 pobj cells,into
R3652 T12324 T12325 amod embryonic,stem
R3653 T12325 T12323 nmod stem,cells
R3654 T12326 T12325 punct (,stem
R3655 T12327 T12325 appos ES,stem
R3656 T12328 T12323 punct ),cells
R3657 T12329 T12330 punct [,40
R3658 T12330 T12319 parataxis 40,electroporated
R3659 T12331 T12330 punct ],40
R3660 T12332 T12319 punct .,electroporated
R3661 T12334 T12335 amod Homologous,recombinants
R3662 T12335 T12336 nsubjpass recombinants,selected
R3663 T12337 T12336 auxpass were,selected
R3664 T12338 T12336 prep by,selected
R3665 T12339 T12338 pobj PCR,by
R3666 T12340 T12336 advcl using,selected
R3667 T12341 T12342 det the,primers
R3668 T12342 T12340 dobj primers,using
R3669 T12343 T12342 amod following,primers
R3670 T12344 T12342 punct ", ",primers
R3671 T12345 T12342 appos AGN1,primers
R3672 T12346 T12345 punct : ,AGN1
R3673 T12347 T12345 appos 5,AGN1
R3674 T12348 T12347 punct ',5
R3675 T12349 T12347 punct -,5
R3676 T12350 T12347 appos TCGTGCTTTACGGTATCGCCGCTCCCGATT,5
R3677 T12351 T12347 punct -,5
R3678 T12352 T12347 nummod 3,5
R3679 T12353 T12347 punct ',5
R3680 T12354 T12345 prep in,AGN1
R3681 T12355 T12356 det the,cassette
R3682 T12356 T12354 pobj cassette,in
R3683 T12357 T12356 compound PGKneo,cassette
R3684 T12358 T12342 punct ", ",primers
R3685 T12359 T12342 cc and,primers
R3686 T12360 T12342 conj SGN033,primers
R3687 T12361 T12360 punct : ,SGN033
R3688 T12362 T12360 appos 5,SGN033
R3689 T12363 T12362 punct ',5
R3690 T12364 T12362 punct -,5
R3691 T12365 T12362 appos GGACCCGGAAGACATTTGCACGGT,5
R3692 T12366 T12362 punct -,5
R3693 T12367 T12362 nummod 3,5
R3694 T12368 T12362 punct ',5
R3695 T12369 T12360 prep outside,SGN033
R3696 T12370 T12371 det the,vector
R3697 T12371 T12369 pobj vector,outside
R3698 T12372 T12371 compound targeting,vector
R3699 T12373 T12336 punct .,selected
R3700 T12375 T12376 amod Homologous,DNA
R3701 T12376 T12378 nsubjpass DNA,amplified
R3702 T12377 T12376 amod recombined,DNA
R3703 T12379 T12378 auxpass was,amplified
R3704 T12380 T12378 advmod efficiently,amplified
R3705 T12381 T12378 agent by,amplified
R3706 T12382 T12383 nummod 35,cycles
R3707 T12383 T12381 pobj cycles,by
R3708 T12384 T12383 prep of,cycles
R3709 T12385 T12386 det the,steps
R3710 T12386 T12384 pobj steps,of
R3711 T12387 T12386 amod following,steps
R3712 T12388 T12386 compound amplification,steps
R3713 T12389 T12386 punct (,steps
R3714 T12390 T12391 nummod 94,°C
R3715 T12391 T12386 appos °C,steps
R3716 T12392 T12391 punct -,°C
R3717 T12393 T12394 nummod 30,sec
R3718 T12394 T12391 npadvmod sec,°C
R3719 T12395 T12391 cc and,°C
R3720 T12396 T12397 nummod 68,°C
R3721 T12397 T12391 conj °C,°C
R3722 T12398 T12397 punct -,°C
R3723 T12399 T12400 nummod 5,min
R3724 T12400 T12397 npadvmod min,°C
R3725 T12401 T12386 punct ),steps
R3726 T12402 T12378 punct .,amplified
R3727 T12404 T12405 advmod Correctly,targeted
R3728 T12405 T12406 amod targeted,clones
R3729 T12406 T12408 nsubjpass clones,injected
R3730 T12407 T12406 compound ES,clones
R3731 T12409 T12408 auxpass were,injected
R3732 T12410 T12408 prep into,injected
R3733 T12411 T12412 amod fertilised,eggs
R3734 T12412 T12410 pobj eggs,into
R3735 T12413 T12412 compound ICR,eggs
R3736 T12414 T12412 compound mouse,eggs
R3737 T12415 T12408 prep at,injected
R3738 T12416 T12417 det the,stage
R3739 T12417 T12415 pobj stage,at
R3740 T12418 T12419 nummod eight,cell
R3741 T12419 T12417 compound cell,stage
R3742 T12420 T12419 punct -,cell
R3743 T12421 T12408 punct .,injected
R3744 T12423 T12424 det The,chimeras
R3745 T12424 T12427 nsubjpass chimeras,mated
R3746 T12425 T12424 amod resulting,chimeras
R3747 T12426 T12424 amod male,chimeras
R3748 T12428 T12427 auxpass were,mated
R3749 T12429 T12427 prep with,mated
R3750 T12430 T12431 compound C57BL,6NCrj
R3751 T12431 T12433 compound 6NCrj,females
R3752 T12432 T12431 punct /,6NCrj
R3753 T12433 T12429 pobj females,with
R3754 T12434 T12435 punct (,Japan
R3755 T12435 T12427 parataxis Japan,mated
R3756 T12436 T12435 compound Charles,Japan
R3757 T12437 T12435 compound River,Japan
R3758 T12438 T12435 punct ", ",Japan
R3759 T12439 T12435 npadvmod Tokyo,Japan
R3760 T12440 T12435 punct ", ",Japan
R3761 T12441 T12435 npadvmod Japan,Japan
R3762 T12442 T12435 punct ),Japan
R3763 T12443 T12427 punct ", ",mated
R3764 T12444 T12427 cc and,mated
R3765 T12445 T12446 amod resulting,mice
R3766 T12446 T12456 nsubjpass mice,interbred
R3767 T12447 T12446 amod heterozygous,mice
R3768 T12448 T12446 punct (,mice
R3769 T12449 T12450 punct +,-
R3770 T12450 T12446 punct -,mice
R3771 T12451 T12450 punct /,-
R3772 T12452 T12446 punct ),mice
R3773 T12453 T12446 amod male,mice
R3774 T12454 T12453 cc and,male
R3775 T12455 T12453 conj female,male
R3776 T12456 T12427 conj interbred,mated
R3777 T12457 T12456 auxpass were,interbred
R3778 T12458 T12459 aux to,generate
R3779 T12459 T12456 advcl generate,interbred
R3780 T12460 T12461 amod homozygous,mice
R3781 T12461 T12459 dobj mice,generate
R3782 T12462 T12461 punct (,mice
R3783 T12463 T12464 punct -,-
R3784 T12464 T12461 punct -,mice
R3785 T12465 T12464 punct /,-
R3786 T12466 T12461 punct ),mice
R3787 T12467 T12456 punct .,interbred
R3788 T12588 T12589 compound Southern,blot
R3789 T12589 T12590 compound blot,analysis
R3790 T12592 T12593 nmod Mouse,DNA
R3791 T12593 T12595 nsubjpass DNA,extracted
R3792 T12594 T12593 amod genomic,DNA
R3793 T12596 T12593 acl used,DNA
R3794 T12597 T12596 prep for,used
R3795 T12598 T12599 compound Southern,blot
R3796 T12599 T12600 compound blot,analysis
R3797 T12600 T12597 pobj analysis,for
R3798 T12601 T12595 auxpass was,extracted
R3799 T12602 T12595 prep from,extracted
R3800 T12603 T12604 det the,liver
R3801 T12604 T12602 pobj liver,from
R3802 T12605 T12604 prep of,liver
R3803 T12606 T12607 det each,genotype
R3804 T12607 T12605 pobj genotype,of
R3805 T12608 T12595 punct .,extracted
R3806 T12610 T12611 npadvmod BamHI,digested
R3807 T12611 T12613 amod digested,DNA
R3808 T12612 T12611 punct -,digested
R3809 T12613 T12615 nsubjpass DNA,probed
R3810 T12614 T12613 amod genomic,DNA
R3811 T12616 T12615 auxpass was,probed
R3812 T12617 T12615 prep with,probed
R3813 T12618 T12619 det the,probe
R3814 T12619 T12617 pobj probe,with
R3815 T12620 T12619 punct [,probe
R3816 T12621 T12622 npadvmod 32P,labelled
R3817 T12622 T12619 amod labelled,probe
R3818 T12623 T12622 punct ],labelled
R3819 T12624 T12622 punct -,labelled
R3820 T12625 T12619 compound BE2K,probe
R3821 T12626 T12619 punct ", ",probe
R3822 T12627 T12628 dep which,was
R3823 T12628 T12619 relcl was,probe
R3824 T12629 T12630 det a,fragment
R3825 T12630 T12628 attr fragment,was
R3826 T12631 T12632 nummod 2.0,kb
R3827 T12632 T12630 nmod kb,fragment
R3828 T12633 T12632 punct -,kb
R3829 T12634 T12635 nmod BamHI,EcoRI
R3830 T12635 T12630 nmod EcoRI,fragment
R3831 T12636 T12635 punct –,EcoRI
R3832 T12637 T12630 amod genomic,fragment
R3833 T12638 T12630 acl located,fragment
R3834 T12639 T12638 prep in,located
R3835 T12640 T12639 pobj intron,in
R3836 T12641 T12640 nummod 2,intron
R3837 T12642 T12615 punct .,probed
R3838 T13011 T13012 compound Western,blot
R3839 T13012 T13013 compound blot,analysis
R3840 T13015 T13016 det The,absence
R3841 T13016 T13017 nsubjpass absence,confirmed
R3842 T13018 T13016 prep of,absence
R3843 T13019 T13020 compound ADAM11,protein
R3844 T13020 T13018 pobj protein,of
R3845 T13021 T13016 prep in,absence
R3846 T13022 T13023 det the,mice
R3847 T13023 T13021 pobj mice,in
R3848 T13024 T13023 punct (,mice
R3849 T13025 T13026 punct -,-
R3850 T13026 T13023 punct -,mice
R3851 T13027 T13026 punct /,-
R3852 T13028 T13023 punct ),mice
R3853 T13029 T13017 auxpass was,confirmed
R3854 T13030 T13017 agent by,confirmed
R3855 T13031 T13032 compound Western,blot
R3856 T13032 T13033 compound blot,analysis
R3857 T13033 T13030 pobj analysis,by
R3858 T13034 T13017 punct .,confirmed
R3859 T13036 T13037 aux To,be
R3860 T13037 T13038 advcl be,isolated
R3861 T13039 T13037 acomp brief,be
R3862 T13040 T13038 punct ", ",isolated
R3863 T13041 T13042 det the,cerebellum
R3864 T13042 T13038 nsubjpass cerebellum,isolated
R3865 T13043 T13038 auxpass was,isolated
R3866 T13044 T13038 prep from,isolated
R3867 T13045 T13046 det a,mouse
R3868 T13046 T13044 pobj mouse,from
R3869 T13047 T13048 nummod six,month
R3870 T13048 T13049 npadvmod month,old
R3871 T13049 T13046 amod old,mouse
R3872 T13050 T13049 punct -,old
R3873 T13051 T13046 prep of,mouse
R3874 T13052 T13053 det each,genotype
R3875 T13053 T13051 pobj genotype,of
R3876 T13054 T13038 cc and,isolated
R3877 T13055 T13038 conj homogenised,isolated
R3878 T13056 T13055 prep in,homogenised
R3879 T13057 T13058 compound cell,lysis
R3880 T13058 T13059 compound lysis,buffer
R3881 T13059 T13056 pobj buffer,in
R3882 T13060 T13061 punct (,cocktail
R3883 T13061 T13055 parataxis cocktail,homogenised
R3884 T13062 T13063 nummod 50,mM
R3885 T13063 T13064 compound mM,HCl
R3886 T13064 T13061 dep HCl,cocktail
R3887 T13065 T13064 compound Tris,HCl
R3888 T13066 T13064 punct -,HCl
R3889 T13067 T13061 punct ", ",cocktail
R3890 T13068 T13061 dep pH,cocktail
R3891 T13069 T13068 nummod 7.5,pH
R3892 T13070 T13061 punct ", ",cocktail
R3893 T13071 T13072 nummod 100,mM
R3894 T13072 T13073 compound mM,NaCl
R3895 T13073 T13061 dep NaCl,cocktail
R3896 T13074 T13061 punct ", ",cocktail
R3897 T13075 T13076 nummod 1,%
R3898 T13076 T13077 compound %,NP
R3899 T13077 T13061 dep NP,cocktail
R3900 T13078 T13077 punct -,NP
R3901 T13079 T13077 nummod 40,NP
R3902 T13080 T13061 punct ", ",cocktail
R3903 T13081 T13082 compound protease,inhibitor
R3904 T13082 T13061 compound inhibitor,cocktail
R3905 T13083 T13084 punct [,Diagnostics
R3906 T13084 T13061 parataxis Diagnostics,cocktail
R3907 T13085 T13084 compound Roche,Diagnostics
R3908 T13086 T13084 punct ],Diagnostics
R3909 T13087 T13061 punct ),cocktail
R3910 T13088 T13038 punct .,isolated
R3911 T13090 T13091 prep After,concentrated
R3912 T13092 T13090 pobj removal,After
R3913 T13093 T13092 prep of,removal
R3914 T13094 T13095 compound cell,debris
R3915 T13095 T13093 pobj debris,of
R3916 T13096 T13092 prep by,removal
R3917 T13097 T13096 pobj centrifugation,by
R3918 T13098 T13091 punct ", ",concentrated
R3919 T13099 T13100 det the,proteins
R3920 T13100 T13091 nsubjpass proteins,concentrated
R3921 T13101 T13100 amod glycosylated,proteins
R3922 T13102 T13100 prep in,proteins
R3923 T13103 T13104 det the,supernatant
R3924 T13104 T13102 pobj supernatant,in
R3925 T13105 T13091 auxpass were,concentrated
R3926 T13106 T13091 prep by,concentrated
R3927 T13107 T13108 det the,chromatography
R3928 T13108 T13106 pobj chromatography,by
R3929 T13109 T13108 compound affinity,chromatography
R3930 T13110 T13091 advcl using,concentrated
R3931 T13111 T13112 compound Con,4B
R3932 T13112 T13110 dobj 4B,using
R3933 T13113 T13112 compound A,4B
R3934 T13114 T13112 compound Sepharose,4B
R3935 T13115 T13116 punct (,Corp.
R3936 T13116 T13110 parataxis Corp.,using
R3937 T13117 T13116 compound Amersham,Corp.
R3938 T13118 T13116 compound Biosciences,Corp.
R3939 T13119 T13116 punct ),Corp.
R3940 T13120 T13091 punct .,concentrated
R3941 T13122 T13123 det Each,sample
R3942 T13123 T13124 nsubjpass sample,separated
R3943 T13125 T13124 auxpass was,separated
R3944 T13126 T13124 prep on,separated
R3945 T13127 T13128 nummod 10,%
R3946 T13128 T13129 compound %,PAGE
R3947 T13129 T13126 pobj PAGE,on
R3948 T13130 T13129 compound SDS,PAGE
R3949 T13131 T13129 punct -,PAGE
R3950 T13132 T13124 punct ", ",separated
R3951 T13133 T13124 cc and,separated
R3952 T13134 T13124 conj transferred,separated
R3953 T13135 T13134 prep to,transferred
R3954 T13136 T13137 det a,membrane
R3955 T13137 T13135 pobj membrane,to
R3956 T13138 T13137 compound PVDF,membrane
R3957 T13139 T13124 punct .,separated
R3958 T13141 T13142 det The,blot
R3959 T13142 T13143 nsubjpass blot,incubated
R3960 T13144 T13143 auxpass was,incubated
R3961 T13145 T13143 advmod then,incubated
R3962 T13146 T13143 prep with,incubated
R3963 T13147 T13148 amod monoclonal,antibody
R3964 T13148 T13146 pobj antibody,with
R3965 T13149 T13148 prep against,antibody
R3966 T13150 T13151 det the,ADAM11
R3967 T13151 T13149 pobj ADAM11,against
R3968 T13152 T13153 punct (,Patent
R3969 T13153 T13151 parataxis Patent,ADAM11
R3970 T13154 T13155 compound U.,S.
R3971 T13155 T13153 compound S.,Patent
R3972 T13156 T13153 nummod "5,631,351",Patent
R3973 T13157 T13153 punct ),Patent
R3974 T13158 T13148 prep at,antibody
R3975 T13159 T13160 nummod 1,μg
R3976 T13160 T13158 pobj μg,at
R3977 T13161 T13162 punct /,ml
R3978 T13162 T13160 prep ml,μg
R3979 T13163 T13143 punct .,incubated
R3980 T13165 T13166 amod Bound,antibodies
R3981 T13166 T13167 nsubjpass antibodies,visualised
R3982 T13168 T13167 auxpass were,visualised
R3983 T13169 T13167 prep with,visualised
R3984 T13170 T13171 compound horseradish,peroxidase
R3985 T13171 T13172 npadvmod peroxidase,labelled
R3986 T13172 T13174 amod labelled,antibody
R3987 T13173 T13172 punct -,labelled
R3988 T13174 T13169 pobj antibody,with
R3989 T13175 T13174 amod second,antibody
R3990 T13176 T13174 cc and,antibody
R3991 T13177 T13178 det an,system
R3992 T13178 T13174 conj system,antibody
R3993 T13179 T13180 compound ECL,plus
R3994 T13180 T13178 compound plus,system
R3995 T13181 T13180 punct -,plus
R3996 T13182 T13183 compound chemiluminescence,detection
R3997 T13183 T13178 compound detection,system
R3998 T13184 T13185 punct (,Corp.
R3999 T13185 T13167 parataxis Corp.,visualised
R4000 T13186 T13185 compound Amersham,Corp.
R4001 T13187 T13185 compound Biosciences,Corp.
R4002 T13188 T13185 punct ),Corp.
R4003 T13189 T13167 punct .,visualised
R4004 T13416 T13417 amod Behavioural,analysis
R4005 T13419 T13420 det All,procedures
R4006 T13420 T13422 nsubj procedures,conformed
R4007 T13421 T13420 compound animal,procedures
R4008 T13423 T13422 prep to,conformed
R4009 T13424 T13425 det the,regulations
R4010 T13425 T13423 pobj regulations,to
R4011 T13426 T13425 amod Japanese,regulations
R4012 T13427 T13425 prep on,regulations
R4013 T13428 T13429 compound animal,care
R4014 T13429 T13427 pobj care,on
R4015 T13430 T13429 cc and,care
R4016 T13431 T13429 conj use,care
R4017 T13432 T13425 punct ", ",regulations
R4018 T13433 T13425 prep following,regulations
R4019 T13434 T13435 det the,Guideline
R4020 T13435 T13433 pobj Guideline,following
R4021 T13436 T13435 prep for,Guideline
R4022 T13437 T13438 compound Animal,Experimentation
R4023 T13438 T13436 pobj Experimentation,for
R4024 T13439 T13435 prep of,Guideline
R4025 T13440 T13441 det the,Association
R4026 T13441 T13439 pobj Association,of
R4027 T13442 T13441 compound Japanese,Association
R4028 T13443 T13441 prep for,Association
R4029 T13444 T13443 pobj Laboratory,for
R4030 T13445 T13444 prep of,Laboratory
R4031 T13446 T13447 compound Animal,Science
R4032 T13447 T13445 pobj Science,of
R4033 T13448 T13422 punct ", ",conformed
R4034 T13449 T13422 cc and,conformed
R4035 T13450 T13451 auxpass were,approved
R4036 T13451 T13422 conj approved,conformed
R4037 T13452 T13451 agent by,approved
R4038 T13453 T13454 det the,Committee
R4039 T13454 T13452 pobj Committee,by
R4040 T13455 T13456 nmod Animal,Care
R4041 T13456 T13454 nmod Care,Committee
R4042 T13457 T13456 cc and,Care
R4043 T13458 T13456 conj Use,Care
R4044 T13459 T13454 prep of,Committee
R4045 T13460 T13461 compound Eisai,Co.
R4046 T13461 T13459 pobj Co.,of
R4047 T13462 T13461 punct ", ",Co.
R4048 T13463 T13461 amod Ltd,Co.
R4049 T13464 T13422 punct .,conformed
R4050 T13466 T13467 prep For,used
R4051 T13468 T13469 det the,experiments
R4052 T13469 T13466 pobj experiments,For
R4053 T13470 T13469 amod present,experiments
R4054 T13471 T13467 punct ", ",used
R4055 T13472 T13473 npadvmod ADAM11,deficient
R4056 T13473 T13475 amod deficient,mice
R4057 T13474 T13473 punct -,deficient
R4058 T13475 T13467 nsubjpass mice,used
R4059 T13476 T13475 amod male,mice
R4060 T13477 T13478 punct (,generations
R4061 T13478 T13475 parataxis generations,mice
R4062 T13479 T13478 amod backcrossed,generations
R4063 T13480 T13478 prep into,generations
R4064 T13481 T13482 compound C57BL,6NCrj
R4065 T13482 T13480 pobj 6NCrj,into
R4066 T13483 T13482 punct /,6NCrj
R4067 T13484 T13478 punct ", ",generations
R4068 T13485 T13486 nsubj n,14
R4069 T13486 T13478 ccomp 14,generations
R4070 T13487 T13486 punct =,14
R4071 T13488 T13478 punct ),generations
R4072 T13489 T13467 auxpass were,used
R4073 T13490 T13467 prep in,used
R4074 T13491 T13492 det all,analyses
R4075 T13492 T13490 pobj analyses,in
R4076 T13493 T13492 amod behavioural,analyses
R4077 T13494 T13495 punct (,weeks
R4078 T13495 T13467 parataxis weeks,used
R4079 T13496 T13497 quantmod 22,24
R4080 T13497 T13495 nummod 24,weeks
R4081 T13498 T13497 punct –,24
R4082 T13499 T13495 prep of,weeks
R4083 T13500 T13499 pobj age,of
R4084 T13501 T13495 punct ),weeks
R4085 T13502 T13467 punct .,used
R4086 T13504 T13505 nsubjpass All,conducted
R4087 T13506 T13504 prep of,All
R4088 T13507 T13508 det the,studies
R4089 T13508 T13506 pobj studies,of
R4090 T13509 T13508 amod behavioural,studies
R4091 T13510 T13505 auxpass were,conducted
R4092 T13511 T13505 prep between,conducted
R4093 T13512 T13513 nummod 10,00
R4094 T13513 T13511 pobj 00,between
R4095 T13514 T13513 punct :,00
R4096 T13515 T13513 cc and,00
R4097 T13516 T13517 nummod 16,00
R4098 T13517 T13513 conj 00,00
R4099 T13518 T13517 punct :,00
R4100 T13519 T13505 agent by,conducted
R4101 T13520 T13521 det a,experimenter
R4102 T13521 T13519 pobj experimenter,by
R4103 T13522 T13523 advmod well,trained
R4104 T13523 T13521 amod trained,experimenter
R4105 T13524 T13523 punct -,trained
R4106 T13525 T13521 amod blind,experimenter
R4107 T13526 T13525 prep to,blind
R4108 T13527 T13528 det the,genotypes
R4109 T13528 T13526 pobj genotypes,to
R4110 T13529 T13528 compound mouse,genotypes
R4111 T13530 T13505 punct .,conducted
R4112 T13661 T13662 amod Spontaneous,activity
R4113 T13663 T13662 compound motor,activity
R4114 T13665 T13666 compound Locomotor,activity
R4115 T13666 T13667 nsubjpass activity,measured
R4116 T13668 T13666 prep in,activity
R4117 T13669 T13670 det a,environment
R4118 T13670 T13668 pobj environment,in
R4119 T13671 T13670 amod novel,environment
R4120 T13672 T13667 auxpass was,measured
R4121 T13673 T13667 prep by,measured
R4122 T13674 T13673 pcomp introducing,by
R4123 T13675 T13674 dobj mice,introducing
R4124 T13676 T13677 punct (,+
R4125 T13677 T13674 punct +,introducing
R4126 T13678 T13677 punct +,+
R4127 T13679 T13677 punct /,+
R4128 T13680 T13677 punct ", ",+
R4129 T13681 T13682 punct +,-
R4130 T13682 T13677 conj -,+
R4131 T13683 T13682 punct /,-
R4132 T13684 T13682 cc and,-
R4133 T13685 T13686 punct -,-
R4134 T13686 T13682 conj -,-
R4135 T13687 T13686 punct /,-
R4136 T13688 T13677 punct ;,+
R4137 T13689 T13690 nsubj n,8
R4138 T13690 T13677 ccomp 8,+
R4139 T13691 T13690 punct =,8
R4140 T13692 T13690 punct ", ",8
R4141 T13693 T13690 conj 8,8
R4142 T13694 T13693 cc and,8
R4143 T13695 T13693 conj 8,8
R4144 T13696 T13690 punct ", ",8
R4145 T13697 T13690 advmod respectively,8
R4146 T13698 T13677 punct ),+
R4147 T13699 T13667 prep for,measured
R4148 T13700 T13701 nummod 90,min
R4149 T13701 T13699 pobj min,for
R4150 T13702 T13667 prep in,measured
R4151 T13703 T13704 det a,box
R4152 T13704 T13702 pobj box,in
R4153 T13705 T13704 compound Plexiglas,box
R4154 T13706 T13707 punct (,cm
R4155 T13707 T13704 parataxis cm,box
R4156 T13708 T13707 nummod 30,cm
R4157 T13709 T13710 punct ×,20
R4158 T13710 T13708 prep 20,30
R4159 T13711 T13712 punct ×,13
R4160 T13712 T13708 prep 13,30
R4161 T13713 T13707 punct ),cm
R4162 T13714 T13667 advcl using,measured
R4163 T13715 T13716 det a,equipment
R4164 T13716 T13714 dobj equipment,using
R4165 T13717 T13716 compound VERSAMAX,equipment
R4166 T13718 T13716 cc and,equipment
R4167 T13719 T13716 conj software,equipment
R4168 T13720 T13721 punct (,Accuscan
R4169 T13721 T13716 parataxis Accuscan,equipment
R4170 T13722 T13721 punct ", ",Accuscan
R4171 T13723 T13721 npadvmod Columbus,Accuscan
R4172 T13724 T13721 punct ", ",Accuscan
R4173 T13725 T13721 npadvmod OH,Accuscan
R4174 T13726 T13721 punct ", ",Accuscan
R4175 T13727 T13721 npadvmod USA,Accuscan
R4176 T13728 T13721 punct ),Accuscan
R4177 T13729 T13667 punct .,measured
R4178 T14364 T14365 compound Water,maze
R4179 T14365 T14366 compound maze,task
R4180 T14368 T14369 amod Spatial,learning
R4181 T14369 T14370 nsubjpass learning,assessed
R4182 T14371 T14370 auxpass was,assessed
R4183 T14372 T14370 prep by,assessed
R4184 T14373 T14374 nummod three,variants
R4185 T14374 T14372 pobj variants,by
R4186 T14375 T14374 prep of,variants
R4187 T14376 T14377 det the,task
R4188 T14377 T14375 pobj task,of
R4189 T14378 T14377 compound Morris,task
R4190 T14379 T14380 compound water,maze
R4191 T14380 T14377 compound maze,task
R4192 T14381 T14382 punct [,27
R4193 T14382 T14377 parataxis 27,task
R4194 T14383 T14382 punct ],27
R4195 T14384 T14374 acl adapted,variants
R4196 T14385 T14384 prep for,adapted
R4197 T14386 T14385 pobj mice,for
R4198 T14387 T14370 punct .,assessed
R4199 T14389 T14390 amod Hidden,task
R4200 T14390 T14392 dep task,divided
R4201 T14391 T14390 compound platform,task
R4202 T14393 T14392 punct : ,divided
R4203 T14394 T14395 det The,pool
R4204 T14395 T14392 nsubjpass pool,divided
R4205 T14396 T14392 auxpass was,divided
R4206 T14397 T14392 prep into,divided
R4207 T14398 T14399 nummod four,quadrants
R4208 T14399 T14397 pobj quadrants,into
R4209 T14400 T14401 mark with,at
R4210 T14401 T14392 advcl at,divided
R4211 T14402 T14403 nummod four,locations
R4212 T14403 T14401 nsubj locations,at
R4213 T14404 T14403 compound starting,locations
R4214 T14405 T14403 punct ", ",locations
R4215 T14406 T14403 acl called,locations
R4216 T14407 T14406 oprd north,called
R4217 T14408 T14407 punct ", ",north
R4218 T14409 T14407 conj east,north
R4219 T14410 T14409 punct ", ",east
R4220 T14411 T14409 conj south,east
R4221 T14412 T14411 cc and,south
R4222 T14413 T14411 conj west,south
R4223 T14414 T14401 punct ", ",at
R4224 T14415 T14416 amod equal,distances
R4225 T14416 T14401 pobj distances,at
R4226 T14417 T14416 prep to,distances
R4227 T14418 T14419 det the,rim
R4228 T14419 T14417 pobj rim,to
R4229 T14420 T14392 punct .,divided
R4230 T14422 T14423 det A,platform
R4231 T14423 T14428 nsubjpass platform,submerged
R4232 T14424 T14423 amod circular,platform
R4233 T14425 T14423 punct ", ",platform
R4234 T14426 T14423 amod transparent,platform
R4235 T14427 T14423 amod acrylic,platform
R4236 T14429 T14430 punct (,cm
R4237 T14430 T14423 parataxis cm,platform
R4238 T14431 T14430 nmod diameter,cm
R4239 T14432 T14430 nummod 8,cm
R4240 T14433 T14430 punct ),cm
R4241 T14434 T14428 auxpass was,submerged
R4242 T14435 T14436 nummod 1,cm
R4243 T14436 T14437 npadvmod cm,below
R4244 T14437 T14428 prep below,submerged
R4245 T14438 T14439 det the,surface
R4246 T14439 T14437 pobj surface,below
R4247 T14440 T14439 prep of,surface
R4248 T14441 T14442 det the,water
R4249 T14442 T14440 pobj water,of
R4250 T14443 T14428 prep in,submerged
R4251 T14444 T14445 det the,centre
R4252 T14445 T14443 pobj centre,in
R4253 T14446 T14445 prep of,centre
R4254 T14447 T14448 det the,quadrant
R4255 T14448 T14446 pobj quadrant,of
R4256 T14449 T14448 compound southeast,quadrant
R4257 T14450 T14428 prep for,submerged
R4258 T14451 T14452 det each,trial
R4259 T14452 T14450 pobj trial,for
R4260 T14453 T14452 prep of,trial
R4261 T14454 T14455 det this,task
R4262 T14455 T14453 pobj task,of
R4263 T14456 T14428 punct .,submerged
R4264 T14458 T14459 det Each,mouse
R4265 T14459 T14460 nsubjpass mouse,allowed
R4266 T14461 T14460 auxpass was,allowed
R4267 T14462 T14463 aux to,swim
R4268 T14463 T14460 xcomp swim,allowed
R4269 T14464 T14463 prep for,swim
R4270 T14465 T14466 nummod 60,sec
R4271 T14466 T14464 pobj sec,for
R4272 T14467 T14460 cc and,allowed
R4273 T14468 T14469 det the,time
R4274 T14469 T14470 nsubjpass time,recorded
R4275 T14470 T14460 conj recorded,allowed
R4276 T14471 T14469 acl required,time
R4277 T14472 T14473 aux to,reach
R4278 T14473 T14471 xcomp reach,required
R4279 T14474 T14475 det the,platform
R4280 T14475 T14473 dobj platform,reach
R4281 T14476 T14469 punct (,time
R4282 T14477 T14478 compound escape,latency
R4283 T14478 T14469 appos latency,time
R4284 T14479 T14469 punct ),time
R4285 T14480 T14470 auxpass was,recorded
R4286 T14481 T14470 prep in,recorded
R4287 T14482 T14483 det each,trial
R4288 T14483 T14481 pobj trial,in
R4289 T14484 T14470 punct .,recorded
R4290 T14486 T14487 prep In,consisted
R4291 T14488 T14486 amod total,In
R4292 T14489 T14490 det this,task
R4293 T14490 T14487 nsubj task,consisted
R4294 T14491 T14487 prep of,consisted
R4295 T14492 T14493 nummod four,trials
R4296 T14493 T14491 pobj trials,of
R4297 T14494 T14493 prep per,trials
R4298 T14495 T14494 pobj day,per
R4299 T14496 T14487 prep over,consisted
R4300 T14497 T14498 nummod 9,days
R4301 T14498 T14496 pobj days,over
R4302 T14499 T14500 punct (,intervals
R4303 T14500 T14498 parataxis intervals,days
R4304 T14501 T14502 nummod 1,min
R4305 T14502 T14500 nmod min,intervals
R4306 T14503 T14500 amod inter-trial,intervals
R4307 T14504 T14500 punct ),intervals
R4308 T14505 T14487 punct .,consisted
R4309 T14507 T14508 det Each,trial
R4310 T14508 T14509 nsubjpass trial,initiated
R4311 T14510 T14509 auxpass was,initiated
R4312 T14511 T14509 agent by,initiated
R4313 T14512 T14513 advmod randomly,placing
R4314 T14513 T14511 pcomp placing,by
R4315 T14514 T14515 det an,animal
R4316 T14515 T14513 dobj animal,placing
R4317 T14516 T14513 prep in,placing
R4318 T14517 T14516 pobj one,in
R4319 T14518 T14517 prep of,one
R4320 T14519 T14520 det the,locations
R4321 T14520 T14518 pobj locations,of
R4322 T14521 T14520 nummod four,locations
R4323 T14522 T14520 compound starting,locations
R4324 T14523 T14509 punct .,initiated
R4325 T14525 T14526 compound Probe,trial
R4326 T14526 T14527 dep trial,carried
R4327 T14528 T14527 punct : ,carried
R4328 T14529 T14530 det A,trial
R4329 T14530 T14527 nsubjpass trial,carried
R4330 T14531 T14530 amod single,trial
R4331 T14532 T14530 compound probe,trial
R4332 T14533 T14527 auxpass was,carried
R4333 T14534 T14527 prt out,carried
R4334 T14535 T14536 mark after,completed
R4335 T14536 T14527 advcl completed,carried
R4336 T14537 T14538 det the,task
R4337 T14538 T14536 nsubjpass task,completed
R4338 T14539 T14540 amod hidden,platform
R4339 T14540 T14538 compound platform,task
R4340 T14541 T14536 aux had,completed
R4341 T14542 T14536 auxpass been,completed
R4342 T14543 T14527 punct .,carried
R4343 T14545 T14546 prep In,removed
R4344 T14547 T14548 det this,trial
R4345 T14548 T14545 pobj trial,In
R4346 T14549 T14546 punct ", ",removed
R4347 T14550 T14551 det the,platform
R4348 T14551 T14546 nsubjpass platform,removed
R4349 T14552 T14546 auxpass was,removed
R4350 T14553 T14546 cc and,removed
R4351 T14554 T14555 det the,movement
R4352 T14555 T14556 nsubjpass movement,monitored
R4353 T14556 T14546 conj monitored,removed
R4354 T14557 T14555 prep of,movement
R4355 T14558 T14559 det each,mouse
R4356 T14559 T14557 pobj mouse,of
R4357 T14560 T14556 auxpass was,monitored
R4358 T14561 T14556 advcl using,monitored
R4359 T14562 T14563 det a,system
R4360 T14563 T14561 dobj system,using
R4361 T14564 T14565 npadvmod computer,based
R4362 T14565 T14563 amod based,system
R4363 T14566 T14565 punct -,based
R4364 T14567 T14568 compound video,tracking
R4365 T14568 T14563 compound tracking,system
R4366 T14569 T14570 punct (,Co.
R4367 T14570 T14561 parataxis Co.,using
R4368 T14571 T14570 dep BTA,Co.
R4369 T14572 T14571 punct -,BTA
R4370 T14573 T14571 nummod 2,BTA
R4371 T14574 T14570 punct ;,Co.
R4372 T14575 T14570 compound Muromachi,Co.
R4373 T14576 T14570 compound Kikai,Co.
R4374 T14577 T14570 punct ", ",Co.
R4375 T14578 T14570 amod Ltd.,Co.
R4376 T14579 T14570 punct ", ",Co.
R4377 T14580 T14570 npadvmod Tokyo,Co.
R4378 T14581 T14570 punct ", ",Co.
R4379 T14582 T14570 npadvmod Japan,Co.
R4380 T14583 T14570 punct ),Co.
R4381 T14584 T14546 punct .,removed
R4382 T14586 T14587 det Each,mouse
R4383 T14587 T14588 nsubjpass mouse,placed
R4384 T14589 T14588 auxpass was,placed
R4385 T14590 T14588 prep into,placed
R4386 T14591 T14592 det the,quadrant
R4387 T14592 T14590 pobj quadrant,into
R4388 T14593 T14592 compound northwest,quadrant
R4389 T14594 T14592 prep of,quadrant
R4390 T14595 T14596 det the,pool
R4391 T14596 T14594 pobj pool,of
R4392 T14597 T14588 cc and,placed
R4393 T14598 T14588 conj allowed,placed
R4394 T14599 T14600 aux to,swim
R4395 T14600 T14598 xcomp swim,allowed
R4396 T14601 T14600 prep for,swim
R4397 T14602 T14603 nummod 60,sec
R4398 T14603 T14601 pobj sec,for
R4399 T14604 T14588 punct .,placed
R4400 T14606 T14607 compound Swim,path
R4401 T14607 T14608 compound path,length
R4402 T14608 T14609 nsubjpass length,calculated
R4403 T14610 T14608 cc and,length
R4404 T14611 T14612 det the,time
R4405 T14612 T14608 conj time,length
R4406 T14613 T14612 acl spent,time
R4407 T14614 T14613 prep in,spent
R4408 T14615 T14616 det the,quadrant
R4409 T14616 T14614 pobj quadrant,in
R4410 T14617 T14616 amod trained,quadrant
R4411 T14618 T14616 punct (,quadrant
R4412 T14619 T14616 nmod southeast,quadrant
R4413 T14620 T14616 punct ),quadrant
R4414 T14621 T14609 auxpass were,calculated
R4415 T14622 T14609 punct .,calculated
R4416 T14624 T14625 amod Visible,task
R4417 T14625 T14627 dep task,made
R4418 T14626 T14625 compound platform,task
R4419 T14628 T14627 punct : ,made
R4420 T14629 T14627 prep In,made
R4421 T14630 T14631 det this,task
R4422 T14631 T14629 pobj task,In
R4423 T14632 T14627 punct ", ",made
R4424 T14633 T14634 det the,platform
R4425 T14634 T14627 nsubjpass platform,made
R4426 T14635 T14634 amod circular,platform
R4427 T14636 T14627 auxpass was,made
R4428 T14637 T14627 oprd visible,made
R4429 T14638 T14627 prep by,made
R4430 T14639 T14638 pcomp attaching,by
R4431 T14640 T14641 det a,board
R4432 T14641 T14639 dobj board,attaching
R4433 T14642 T14641 amod black,board
R4434 T14643 T14639 prep to,attaching
R4435 T14644 T14643 pobj it,to
R4436 T14645 T14627 cc and,made
R4437 T14646 T14647 det the,mouse
R4438 T14647 T14648 nsubjpass mouse,required
R4439 T14648 T14627 conj required,made
R4440 T14649 T14648 auxpass was,required
R4441 T14650 T14651 aux to,locate
R4442 T14651 T14648 advcl locate,required
R4443 T14652 T14653 det the,platform
R4444 T14653 T14651 dobj platform,locate
R4445 T14654 T14653 amod visible,platform
R4446 T14655 T14627 punct .,made
R4447 T14657 T14658 det The,mouse
R4448 T14658 T14659 nsubjpass mouse,allowed
R4449 T14660 T14659 auxpass was,allowed
R4450 T14661 T14662 aux to,swim
R4451 T14662 T14659 xcomp swim,allowed
R4452 T14663 T14662 prep for,swim
R4453 T14664 T14665 nummod 60,sec
R4454 T14665 T14663 pobj sec,for
R4455 T14666 T14659 cc and,allowed
R4456 T14667 T14668 det this,task
R4457 T14668 T14669 nsubj task,consisted
R4458 T14669 T14659 conj consisted,allowed
R4459 T14670 T14669 prep of,consisted
R4460 T14671 T14672 nummod four,trials
R4461 T14672 T14670 pobj trials,of
R4462 T14673 T14672 prep per,trials
R4463 T14674 T14673 pobj day,per
R4464 T14675 T14672 prep for,trials
R4465 T14676 T14677 nummod three,days
R4466 T14677 T14675 pobj days,for
R4467 T14678 T14677 amod consecutive,days
R4468 T14679 T14680 punct (,intervals
R4469 T14680 T14672 parataxis intervals,trials
R4470 T14681 T14682 nummod 1,min
R4471 T14682 T14680 nmod min,intervals
R4472 T14683 T14680 amod inter-trial,intervals
R4473 T14684 T14680 punct ),intervals
R4474 T14685 T14669 punct .,consisted
R4475 T14687 T14688 det Each,trial
R4476 T14688 T14689 nsubjpass trial,initiated
R4477 T14690 T14689 auxpass was,initiated
R4478 T14691 T14689 agent by,initiated
R4479 T14692 T14693 advmod randomly,placing
R4480 T14693 T14691 pcomp placing,by
R4481 T14694 T14695 det an,animal
R4482 T14695 T14693 dobj animal,placing
R4483 T14696 T14693 prep in,placing
R4484 T14697 T14696 pobj one,in
R4485 T14698 T14697 prep of,one
R4486 T14699 T14700 det the,locations
R4487 T14700 T14698 pobj locations,of
R4488 T14701 T14700 nummod four,locations
R4489 T14702 T14700 compound starting,locations
R4490 T14703 T14689 punct .,initiated
R4491 T14924 T14925 amod Rotating,rod
R4492 T14925 T14926 compound rod,test
R4493 T14928 T14929 compound Motor,coordination
R4494 T14929 T14930 nsubjpass coordination,assessed
R4495 T14931 T14930 auxpass was,assessed
R4496 T14932 T14930 prep with,assessed
R4497 T14933 T14934 det a,apparatus
R4498 T14934 T14932 pobj apparatus,with
R4499 T14935 T14936 amod rotating,rod
R4500 T14936 T14934 compound rod,apparatus
R4501 T14937 T14938 punct (,Seisakujo
R4502 T14938 T14934 parataxis Seisakujo,apparatus
R4503 T14939 T14938 dep KN,Seisakujo
R4504 T14940 T14939 punct -,KN
R4505 T14941 T14939 nummod 75,KN
R4506 T14942 T14938 punct ", ",Seisakujo
R4507 T14943 T14938 compound Natsume,Seisakujo
R4508 T14944 T14938 punct ", ",Seisakujo
R4509 T14945 T14938 npadvmod Tokyo,Seisakujo
R4510 T14946 T14938 punct ", ",Seisakujo
R4511 T14947 T14938 npadvmod Japan,Seisakujo
R4512 T14948 T14938 punct ),Seisakujo
R4513 T14949 T14934 punct ", ",apparatus
R4514 T14950 T14951 dep which,consisted
R4515 T14951 T14934 relcl consisted,apparatus
R4516 T14952 T14951 prep of,consisted
R4517 T14953 T14954 det a,rod
R4518 T14954 T14952 pobj rod,of
R4519 T14955 T14954 compound plastic,rod
R4520 T14956 T14957 punct (,diameter
R4521 T14957 T14954 parataxis diameter,rod
R4522 T14958 T14959 nummod 3,cm
R4523 T14959 T14957 compound cm,diameter
R4524 T14960 T14957 punct ", ",diameter
R4525 T14961 T14962 nummod 8,cm
R4526 T14962 T14963 npadvmod cm,long
R4527 T14963 T14957 amod long,diameter
R4528 T14964 T14957 punct ),diameter
R4529 T14965 T14954 prep with,rod
R4530 T14966 T14967 det a,surface
R4531 T14967 T14965 pobj surface,with
R4532 T14968 T14967 amod gritted,surface
R4533 T14969 T14967 acl flanked,surface
R4534 T14970 T14969 agent by,flanked
R4535 T14971 T14972 nummod two,discs
R4536 T14972 T14970 pobj discs,by
R4537 T14973 T14972 amod large,discs
R4538 T14974 T14975 punct (,diameter
R4539 T14975 T14972 parataxis diameter,discs
R4540 T14976 T14977 nummod 40,cm
R4541 T14977 T14975 compound cm,diameter
R4542 T14978 T14975 punct ),diameter
R4543 T14979 T14930 punct .,assessed
R4544 T14981 T14982 det The,mice
R4545 T14982 T14983 nsubjpass mice,placed
R4546 T14984 T14983 auxpass were,placed
R4547 T14985 T14983 advmod first,placed
R4548 T14986 T14983 prep on,placed
R4549 T14987 T14988 det the,rod
R4550 T14988 T14986 pobj rod,on
R4551 T14989 T14988 amod stationary,rod
R4552 T14990 T14983 prep for,placed
R4553 T14991 T14992 nummod 4,trials
R4554 T14992 T14990 pobj trials,for
R4555 T14993 T14992 amod successive,trials
R4556 T14994 T14992 punct ", ",trials
R4557 T14995 T14992 acl followed,trials
R4558 T14996 T14995 agent by,followed
R4559 T14997 T14998 nummod 4,trials
R4560 T14998 T14996 pobj trials,by
R4561 T14999 T14998 prep at,trials
R4562 T15000 T15001 det a,speed
R4563 T15001 T14999 pobj speed,at
R4564 T15002 T15001 compound rotation,speed
R4565 T15003 T15001 prep of,speed
R4566 T15004 T15005 nummod 5,rpm
R4567 T15005 T15003 pobj rpm,of
R4568 T15006 T14998 punct ", ",trials
R4569 T15007 T15008 nummod 8,trials
R4570 T15008 T14998 conj trials,trials
R4571 T15009 T15008 prep at,trials
R4572 T15010 T15011 nummod 10,rpm
R4573 T15011 T15009 pobj rpm,at
R4574 T15012 T15008 punct ", ",trials
R4575 T15013 T15008 cc and,trials
R4576 T15014 T15015 nummod 20,trials
R4577 T15015 T15008 conj trials,trials
R4578 T15016 T15015 prep at,trials
R4579 T15017 T15018 nummod 15,rpm
R4580 T15018 T15016 pobj rpm,at
R4581 T15019 T14998 prep in,trials
R4582 T15020 T15021 det that,order
R4583 T15021 T15019 pobj order,in
R4584 T15022 T14983 punct .,placed
R4585 T15024 T15025 nsubjpass Latency,monitored
R4586 T15026 T15027 mark until,occurred
R4587 T15027 T15024 advcl occurred,Latency
R4588 T15028 T15029 det a,fall
R4589 T15029 T15027 nsubj fall,occurred
R4590 T15030 T15025 auxpass was,monitored
R4591 T15031 T15025 prep for,monitored
R4592 T15032 T15033 nummod 120,sec
R4593 T15033 T15031 pobj sec,for
R4594 T15034 T15025 punct .,monitored
R4595 T15036 T15037 amod Intra-trial,intervals
R4596 T15037 T15038 nsubj intervals,were
R4597 T15039 T15037 prep for,intervals
R4598 T15040 T15041 det each,animal
R4599 T15041 T15039 pobj animal,for
R4600 T15042 T15043 amod more,20
R4601 T15043 T15045 nummod 20,min
R4602 T15044 T15043 quantmod than,20
R4603 T15045 T15038 attr min,were
R4604 T15046 T15038 punct .,were
R4605 T15164 T15165 compound Traction,test
R4606 T15167 T15168 det The,strength
R4607 T15168 T15170 nsubjpass strength,measured
R4608 T15169 T15168 compound grip,strength
R4609 T15171 T15168 prep of,strength
R4610 T15172 T15173 det each,mouse
R4611 T15173 T15171 pobj mouse,of
R4612 T15174 T15170 auxpass was,measured
R4613 T15175 T15170 prep with,measured
R4614 T15176 T15177 det a,apparatus
R4615 T15177 T15175 pobj apparatus,with
R4616 T15178 T15177 compound traction,apparatus
R4617 T15179 T15180 punct (,Co.
R4618 T15180 T15177 parataxis Co.,apparatus
R4619 T15181 T15180 dep FU,Co.
R4620 T15182 T15181 punct -,FU
R4621 T15183 T15181 nummod 1,FU
R4622 T15184 T15180 punct ", ",Co.
R4623 T15185 T15180 compound Muromachi,Co.
R4624 T15186 T15180 compound Kikai,Co.
R4625 T15187 T15180 punct ", ",Co.
R4626 T15188 T15180 amod Ltd.,Co.
R4627 T15189 T15180 punct ),Co.
R4628 T15190 T15170 punct .,measured
R4629 T15192 T15193 det Each,mouse
R4630 T15193 T15194 nsubjpass mouse,made
R4631 T15195 T15194 auxpass was,made
R4632 T15196 T15197 aux to,grasp
R4633 T15197 T15194 xcomp grasp,made
R4634 T15198 T15199 det the,bar
R4635 T15199 T15197 dobj bar,grasp
R4636 T15200 T15199 amod attached,bar
R4637 T15201 T15202 punct (,diameter
R4638 T15202 T15199 parataxis diameter,bar
R4639 T15203 T15204 nummod 2,mm
R4640 T15204 T15202 compound mm,diameter
R4641 T15205 T15202 punct ),diameter
R4642 T15206 T15197 prep with,grasp
R4643 T15207 T15208 det the,forepaws
R4644 T15208 T15206 pobj forepaws,with
R4645 T15209 T15194 cc and,made
R4646 T15210 T15211 auxpass was,pulled
R4647 T15211 T15194 conj pulled,made
R4648 T15212 T15211 advmod slowly,pulled
R4649 T15213 T15211 advmod back,pulled
R4650 T15214 T15211 prep by,pulled
R4651 T15215 T15216 det the,tail
R4652 T15216 T15214 pobj tail,by
R4653 T15217 T15194 punct .,made
R4654 T15219 T15220 det The,tension
R4655 T15220 T15222 nsubjpass tension,recorded
R4656 T15221 T15220 amod maximum,tension
R4657 T15223 T15220 prep before,tension
R4658 T15224 T15223 pobj release,before
R4659 T15225 T15222 auxpass was,recorded
R4660 T15226 T15222 punct .,recorded
R4661 T15486 T15487 compound Wire,suspension
R4662 T15487 T15488 compound suspension,test
R4663 T15490 T15491 det A,mouse
R4664 T15491 T15492 nsubjpass mouse,placed
R4665 T15493 T15492 auxpass was,placed
R4666 T15494 T15492 prep on,placed
R4667 T15495 T15496 det a,bar
R4668 T15496 T15494 pobj bar,on
R4669 T15497 T15496 amod stainless,bar
R4670 T15498 T15499 punct (,diameter
R4671 T15499 T15496 parataxis diameter,bar
R4672 T15500 T15501 nummod 50,cm
R4673 T15501 T15502 compound cm,length
R4674 T15502 T15499 dep length,diameter
R4675 T15503 T15499 punct ", ",diameter
R4676 T15504 T15505 nummod 2,mm
R4677 T15505 T15499 compound mm,diameter
R4678 T15506 T15499 punct ", ",diameter
R4679 T15507 T15499 advcl elevated,diameter
R4680 T15508 T15509 advmod up,37
R4681 T15509 T15511 nummod 37,cm
R4682 T15510 T15509 quantmod to,37
R4683 T15511 T15507 npadvmod cm,elevated
R4684 T15512 T15511 prep from,cm
R4685 T15513 T15514 det a,surface
R4686 T15514 T15512 pobj surface,from
R4687 T15515 T15499 punct ),diameter
R4688 T15516 T15492 prep at,placed
R4689 T15517 T15518 det a,midway
R4690 T15518 T15516 pobj midway,at
R4691 T15519 T15518 compound point,midway
R4692 T15520 T15518 prep between,midway
R4693 T15521 T15522 det the,supports
R4694 T15522 T15520 pobj supports,between
R4695 T15523 T15492 cc and,placed
R4696 T15524 T15492 conj observed,placed
R4697 T15525 T15524 prep for,observed
R4698 T15526 T15527 nummod 30,sec
R4699 T15527 T15525 pobj sec,for
R4700 T15528 T15524 prep in,observed
R4701 T15529 T15530 nummod four,trials
R4702 T15530 T15528 pobj trials,in
R4703 T15531 T15530 amod separate,trials
R4704 T15532 T15492 punct .,placed
R4705 T15534 T15535 det The,amount
R4706 T15535 T15536 nsubjpass amount,recorded
R4707 T15537 T15535 prep of,amount
R4708 T15538 T15537 pobj time,of
R4709 T15539 T15538 acl spent,time
R4710 T15540 T15539 advcl hanging,spent
R4711 T15541 T15536 auxpass was,recorded
R4712 T15542 T15536 cc and,recorded
R4713 T15543 T15536 conj scored,recorded
R4714 T15544 T15543 prep according,scored
R4715 T15545 T15544 prep to,according
R4716 T15546 T15547 det the,system
R4717 T15547 T15545 pobj system,to
R4718 T15548 T15547 amod following,system
R4719 T15549 T15550 punct [,41
R4720 T15550 T15543 parataxis 41,scored
R4721 T15551 T15550 punct ],41
R4722 T15552 T15536 punct : ,recorded
R4723 T15553 T15554 dep 0,fell
R4724 T15554 T15556 dep fell,escaped
R4725 T15555 T15554 punct ", ",fell
R4726 T15556 T15536 dep escaped,recorded
R4727 T15557 T15554 prt off,fell
R4728 T15558 T15556 punct ;,escaped
R4729 T15559 T15560 dep 1,hung
R4730 T15560 T15556 dep hung,escaped
R4731 T15561 T15560 punct ", ",hung
R4732 T15562 T15560 prep onto,hung
R4733 T15563 T15564 det the,bar
R4734 T15564 T15562 pobj bar,onto
R4735 T15565 T15560 prep with,hung
R4736 T15566 T15567 nummod two,forepaws
R4737 T15567 T15565 pobj forepaws,with
R4738 T15568 T15556 punct ;,escaped
R4739 T15569 T15570 dep 2,attempted
R4740 T15570 T15556 dep attempted,escaped
R4741 T15571 T15570 punct ", ",attempted
R4742 T15572 T15570 prep in,attempted
R4743 T15573 T15572 pobj addition,in
R4744 T15574 T15573 prep to,addition
R4745 T15575 T15574 pobj 1,to
R4746 T15576 T15570 punct ", ",attempted
R4747 T15577 T15578 aux to,climb
R4748 T15578 T15570 xcomp climb,attempted
R4749 T15579 T15578 prep onto,climb
R4750 T15580 T15581 det the,bar
R4751 T15581 T15579 pobj bar,onto
R4752 T15582 T15556 punct ;,escaped
R4753 T15583 T15584 dep 3,hung
R4754 T15584 T15556 dep hung,escaped
R4755 T15585 T15584 punct ", ",hung
R4756 T15586 T15584 prep onto,hung
R4757 T15587 T15588 det the,bar
R4758 T15588 T15586 pobj bar,onto
R4759 T15589 T15584 prep with,hung
R4760 T15590 T15591 nummod two,forepaws
R4761 T15591 T15589 pobj forepaws,with
R4762 T15592 T15591 cc and,forepaws
R4763 T15593 T15594 nummod one,paws
R4764 T15594 T15591 conj paws,forepaws
R4765 T15595 T15593 cc or,one
R4766 T15596 T15593 preconj both,one
R4767 T15597 T15594 compound hind,paws
R4768 T15598 T15556 punct ;,escaped
R4769 T15599 T15600 dep 4,hung
R4770 T15600 T15556 dep hung,escaped
R4771 T15601 T15600 punct ", ",hung
R4772 T15602 T15600 prep onto,hung
R4773 T15603 T15604 det the,bar
R4774 T15604 T15602 pobj bar,onto
R4775 T15605 T15600 prep with,hung
R4776 T15606 T15607 det all,paws
R4777 T15607 T15605 pobj paws,with
R4778 T15608 T15607 nummod four,paws
R4779 T15609 T15600 prep with,hung
R4780 T15610 T15609 pobj tail,with
R4781 T15611 T15610 acl wrapped,tail
R4782 T15612 T15611 prep around,wrapped
R4783 T15613 T15614 det the,bar
R4784 T15614 T15612 pobj bar,around
R4785 T15615 T15556 punct ;,escaped
R4786 T15616 T15556 dep 5,escaped
R4787 T15617 T15556 punct ", ",escaped
R4788 T15618 T15556 prep to,escaped
R4789 T15619 T15618 pobj one,to
R4790 T15620 T15619 prep of,one
R4791 T15621 T15622 det the,supports
R4792 T15622 T15620 pobj supports,of
R4793 T15623 T15536 punct .,recorded
R4794 T15705 T15706 compound Footprint,test
R4795 T15708 T15709 amod Black,ink
R4796 T15709 T15710 nsubjpass ink,applied
R4797 T15711 T15710 auxpass was,applied
R4798 T15712 T15710 prep to,applied
R4799 T15713 T15714 det the,paws
R4800 T15714 T15712 pobj paws,to
R4801 T15715 T15714 compound hind,paws
R4802 T15716 T15714 prep of,paws
R4803 T15717 T15718 det each,mouse
R4804 T15718 T15716 pobj mouse,of
R4805 T15719 T15710 cc and,applied
R4806 T15720 T15721 det the,mice
R4807 T15721 T15722 nsubjpass mice,placed
R4808 T15722 T15710 conj placed,applied
R4809 T15723 T15722 auxpass were,placed
R4810 T15724 T15722 prep in,placed
R4811 T15725 T15726 det a,alley
R4812 T15726 T15724 pobj alley,in
R4813 T15727 T15726 amod narrow,alley
R4814 T15728 T15729 punct (,cm
R4815 T15729 T15726 parataxis cm,alley
R4816 T15730 T15731 nummod 9,10
R4817 T15731 T15729 nummod 10,cm
R4818 T15732 T15731 punct ×,10
R4819 T15733 T15731 nummod 25,10
R4820 T15734 T15731 punct ×,10
R4821 T15735 T15729 punct ),cm
R4822 T15736 T15722 prep on,placed
R4823 T15737 T15738 amod white,paper
R4824 T15738 T15736 pobj paper,on
R4825 T15739 T15722 punct .,placed
R4826 T15741 T15742 compound Stride,length
R4827 T15742 T15743 nsubjpass length,calculated
R4828 T15744 T15742 cc and,length
R4829 T15745 T15746 compound step,width
R4830 T15746 T15742 conj width,length
R4831 T15747 T15743 auxpass were,calculated
R4832 T15748 T15743 punct .,calculated
R4833 T15951 T15952 nsubjpass Data,expressed
R4834 T15953 T15952 auxpass are,expressed
R4835 T15954 T15952 prep as,expressed
R4836 T15955 T15956 det the,SEM
R4837 T15956 T15954 pobj SEM,as
R4838 T15957 T15956 nmod means,SEM
R4839 T15958 T15956 punct ±,SEM
R4840 T15959 T15952 punct .,expressed
R4841 T15961 T15962 amod Statistical,analysis
R4842 T15962 T15963 nsubjpass analysis,conducted
R4843 T15964 T15963 auxpass was,conducted
R4844 T15965 T15963 advcl using,conducted
R4845 T15966 T15967 det the,package
R4846 T15967 T15965 dobj package,using
R4847 T15968 T15967 compound software,package
R4848 T15969 T15967 appos SAS,package
R4849 T15970 T15969 nummod 8.1,SAS
R4850 T15971 T15972 punct (,Japan
R4851 T15972 T15967 parataxis Japan,package
R4852 T15973 T15972 compound SAS,Japan
R4853 T15974 T15972 compound Institute,Japan
R4854 T15975 T15972 amod Ltd.,Japan
R4855 T15976 T15972 punct ", ",Japan
R4856 T15977 T15972 npadvmod Tokyo,Japan
R4857 T15978 T15972 punct ", ",Japan
R4858 T15979 T15972 npadvmod Japan,Japan
R4859 T15980 T15972 punct ),Japan
R4860 T15981 T15963 punct .,conducted
R4861 T15983 T15984 amod Statistical,significance
R4862 T15984 T15985 nsubjpass significance,determined
R4863 T15986 T15985 auxpass was,determined
R4864 T15987 T15985 prep by,determined
R4865 T15988 T15987 pobj analysis,by
R4866 T15989 T15988 prep of,analysis
R4867 T15990 T15989 pobj variance,of
R4868 T15991 T15988 punct (,analysis
R4869 T15992 T15988 appos ANOVA,analysis
R4870 T15993 T15988 punct ),analysis
R4871 T15994 T15988 acl followed,analysis
R4872 T15995 T15994 agent by,followed
R4873 T15996 T15997 det the,test
R4874 T15997 T15995 pobj test,by
R4875 T15998 T15999 nmod Dunnett,type
R4876 T15999 T15997 nmod type,test
R4877 T16000 T15999 punct -,type
R4878 T16001 T16002 amod multiple,comparison
R4879 T16002 T15997 compound comparison,test
R4880 T16003 T15985 punct ", ",determined
R4881 T16004 T15985 cc and,determined
R4882 T16005 T16006 compound p,values
R4883 T16006 T16007 nsubjpass values,considered
R4884 T16007 T15985 conj considered,determined
R4885 T16008 T16006 prep of,values
R4886 T16009 T16010 amod less,0.05
R4887 T16010 T16008 pobj 0.05,of
R4888 T16011 T16010 quantmod than,0.05
R4889 T16012 T16007 auxpass were,considered
R4890 T16013 T16014 aux to,be
R4891 T16014 T16007 xcomp be,considered
R4892 T16015 T16014 acomp significant,be
R4893 T16016 T16014 prep in,be
R4894 T16017 T16018 det the,task
R4895 T16018 T16016 pobj task,in
R4896 T16019 T16020 compound water,maze
R4897 T16020 T16018 compound maze,task
R4898 T16021 T16007 punct .,considered
R4899 T16023 T16024 amod Behavioural,data
R4900 T16024 T16025 nsubjpass data,analysed
R4901 T16026 T16024 prep in,data
R4902 T16027 T16028 det the,test
R4903 T16028 T16026 pobj test,in
R4904 T16029 T16030 amod rotating,rod
R4905 T16030 T16028 compound rod,test
R4906 T16031 T16025 auxpass were,analysed
R4907 T16032 T16025 agent by,analysed
R4908 T16033 T16034 nummod one,way
R4909 T16034 T16039 compound way,ANOVA
R4910 T16035 T16033 punct -,one
R4911 T16036 T16033 cc or,one
R4912 T16037 T16033 conj two,one
R4913 T16038 T16034 punct -,way
R4914 T16039 T16032 pobj ANOVA,by
R4915 T16040 T16039 prep with,ANOVA
R4916 T16041 T16042 amod repeated,measures
R4917 T16042 T16040 pobj measures,with
R4918 T16043 T16025 punct ", ",analysed
R4919 T16044 T16025 cc and,analysed
R4920 T16045 T16046 compound p,values
R4921 T16046 T16047 nsubjpass values,considered
R4922 T16047 T16025 conj considered,analysed
R4923 T16048 T16046 prep of,values
R4924 T16049 T16050 amod less,0.05
R4925 T16050 T16048 pobj 0.05,of
R4926 T16051 T16050 quantmod than,0.05
R4927 T16052 T16047 auxpass were,considered
R4928 T16053 T16054 aux to,be
R4929 T16054 T16047 xcomp be,considered
R4930 T16055 T16054 acomp significant,be
R4931 T16056 T16047 punct .,considered
R4932 T16223 T16224 nsubjpass Sections,fixed
R4933 T16225 T16223 prep of,Sections
R4934 T16226 T16225 pobj tissues,of
R4935 T16227 T16226 prep including,tissues
R4936 T16228 T16229 det the,brain
R4937 T16229 T16227 pobj brain,including
R4938 T16230 T16229 punct ", ",brain
R4939 T16231 T16232 amod spinal,cord
R4940 T16232 T16229 conj cord,brain
R4941 T16233 T16232 punct ", ",cord
R4942 T16234 T16232 conj heart,cord
R4943 T16235 T16234 punct ", ",heart
R4944 T16236 T16234 conj lung,heart
R4945 T16237 T16236 punct ", ",lung
R4946 T16238 T16236 conj liver,lung
R4947 T16239 T16238 punct ", ",liver
R4948 T16240 T16238 conj kidney,liver
R4949 T16241 T16240 punct ", ",kidney
R4950 T16242 T16240 conj spleen,kidney
R4951 T16243 T16242 cc and,spleen
R4952 T16244 T16242 conj testis,spleen
R4953 T16245 T16223 prep from,Sections
R4954 T16246 T16245 pobj mice,from
R4955 T16247 T16248 punct (,+
R4956 T16248 T16246 punct +,mice
R4957 T16249 T16248 punct +,+
R4958 T16250 T16248 punct /,+
R4959 T16251 T16248 punct ", ",+
R4960 T16252 T16253 punct +,-
R4961 T16253 T16248 conj -,+
R4962 T16254 T16253 punct /,-
R4963 T16255 T16253 cc and,-
R4964 T16256 T16257 punct -,-
R4965 T16257 T16253 conj -,-
R4966 T16258 T16257 punct /,-
R4967 T16259 T16248 punct ;,+
R4968 T16260 T16261 nsubj n,7
R4969 T16261 T16248 ccomp 7,+
R4970 T16262 T16261 punct =,7
R4971 T16263 T16261 punct ", ",7
R4972 T16264 T16261 conj 7,7
R4973 T16265 T16264 cc and,7
R4974 T16266 T16264 conj 7,7
R4975 T16267 T16261 punct ", ",7
R4976 T16268 T16261 advmod respectively,7
R4977 T16269 T16248 punct ),+
R4978 T16270 T16224 auxpass were,fixed
R4979 T16271 T16224 prep in,fixed
R4980 T16272 T16273 nummod 10,%
R4981 T16273 T16274 nmod %,formalin
R4982 T16274 T16271 pobj formalin,in
R4983 T16275 T16274 amod buffered,formalin
R4984 T16276 T16224 cc and,fixed
R4985 T16277 T16224 conj embedded,fixed
R4986 T16278 T16277 prep in,embedded
R4987 T16279 T16278 pobj paraffin,in
R4988 T16280 T16224 punct .,fixed
R4989 T16282 T16283 det Each,section
R4990 T16283 T16285 nsubjpass section,stained
R4991 T16284 T16283 compound paraffin,section
R4992 T16286 T16283 prep of,section
R4993 T16287 T16288 amod thick,μm
R4994 T16288 T16286 pobj μm,of
R4995 T16289 T16288 nummod 4,μm
R4996 T16290 T16285 auxpass was,stained
R4997 T16291 T16285 prep with,stained
R4998 T16292 T16291 pobj hematoxylin,with
R4999 T16293 T16292 cc and,hematoxylin
R5000 T16294 T16292 conj eosin,hematoxylin
R5001 T16295 T16292 punct (,hematoxylin
R5002 T16296 T16292 appos HE,hematoxylin
R5003 T16297 T16285 punct ),stained
R5004 T16298 T16285 punct .,stained
R845 T3265 T3257 advcl introduced,synthesised
R874 T3295 T3300 advcl removed,concluded
R990 T4019 T3998 conj was,yielded
R1069 T4104 T4102 pobj mice,of
R1136 T4174 T4179 nsubjpass change,observed
R1170 T4211 T4209 pobj mice,of
R1228 T4271 T4276 amod dependent,analyses
R10 T575 T577 amod deficient,mice
R23 T593 T583 conj expressed,is
R27 T597 T595 pobj system,in
R35 T607 T605 attr molecule,be
R39 T611 T602 advcl has,thought
R49 T621 T623 nmod cell,interactions
R60 T634 T631 dobj functions,elucidate
R67 T641 T643 amod deficient,mice
R77 T654 T656 amod deficient,mice
R86 T664 T666 nummod one,year
R102 T681 T683 advcl is,examined
R115 T695 T683 dobj mice,examined
R129 T709 T683 conj coordination,examined
R163 T745 T747 amod deficient,mice
R210 T798 T777 conj participate,play
R1769 T6694 T6692 pobj mice,of
R1788 T6713 T6710 ccomp 1.67,0.21
R1822 T6749 T6746 pobj mice,In
R1837 T6764 T6762 pobj rpm,at
R1869 T6796 T6793 ccomp 1.27,0.27
R1885 T6812 T6809 ccomp 1.07,0.31
R1923 T6852 T6849 nsubj mice,fell
R1942 T6871 T6869 pobj rpm,at
R1954 T6883 T6880 ccomp 17.51,0.0002
R1970 T6899 T6896 ccomp 11.05,0.003
R2013 T6944 T6942 pobj mice,in
R2024 T6955 T6953 pobj rpm,at
R2036 T6967 T6964 ccomp 2.05,0.15
R2052 T6983 T6980 ccomp 2.61,0.07
R2093 T7026 T7020 nsubj mice,showed
R2130 T7065 T7063 pobj mice,of
R1444 T5463 T5459 relcl removed,test
R1492 T5513 T5511 pobj mice,of
R1551 T5576 T5574 pobj mice,in
R511 T2522 T2520 pobj genes,of
R2377 T10188 T10183 prep than,time
R2378 T10189 T10190 amod wild,type
R2728 T10565 T10551 acomp shorter,was
R2729 T10566 T10565 prep than,shorter
R2730 T10567 T10568 amod wild,type
R2732 T10568 T10570 compound type,mice
R3080 T10942 T10943 compound adhesion,molecules
R3081 T10943 T10941 nsubjpass molecules,implicated
R3082 T10944 T10943 punct ", ",molecules
R3332 T11239 T11237 ccomp exist,revealed
R3337 T11242 T11240 pobj genes,of
R3340 T11245 T11244 cc and,ADAM22
R3341 T11246 T11244 conj ADAM23,ADAM22
R3342 T11247 T11239 aux to,exist
R3344 T11248 T11239 prep in,exist
R3345 T11249 T11248 pobj vertebrates,in
R3347 T11250 T11251 amod such,as
R3348 T11251 T11249 prep as,vertebrates
R3350 T11252 T11251 pobj mammals,as
R3351 T11253 T11252 punct ", ",mammals
R3352 T11254 T11252 conj fish,mammals
R3354 T11255 T11254 punct ", ",fish
R3355 T11256 T11254 cc and,fish
R3356 T11257 T11254 conj amphibians,fish
R3358 T11258 T11248 punct ", ",in
R3359 T11259 T11248 cc but,in
R3360 T11260 T11259 neg not,but
R3362 T11261 T11248 conj in,in
R3363 T11262 T11261 pobj invertebrates,in
R3364 T11263 T11237 punct .,revealed
R3366 T11265 T11266 mark Although,are
R3368 T11266 T11274 advcl are,provide
R3369 T11267 T11268 det the,functions
R3370 T11268 T11266 nsubj functions,are
R3372 T11269 T11268 amod precise,functions
R3373 T11270 T11268 amod molecular,functions
R3375 T11271 T11268 prep of,functions
R3377 T11272 T11273 det these,ADAMs
R3378 T11273 T11271 pobj ADAMs,of
R3380 T11275 T11266 advmod still,are
R3381 T11276 T11266 acomp unclear,are
R3383 T11277 T11274 punct ", ",provide
R3384 T11278 T11279 amod further,investigations