PMC:1420271 / 4318-5092 JSONTXT

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    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T3796","span":{"begin":50,"end":55},"obj":"NCBITaxon:10088"},{"id":"T3797","span":{"begin":56,"end":60},"obj":"PR:000006847"},{"id":"T3798","span":{"begin":61,"end":65},"obj":"SO:0000704"},{"id":"T3799","span":{"begin":70,"end":81},"obj":"SO:0000336"},{"id":"T3800","span":{"begin":120,"end":125},"obj":"NCBITaxon:10088"},{"id":"T3801","span":{"begin":126,"end":133},"obj":"SO:0001026"},{"id":"T3802","span":{"begin":152,"end":156},"obj":"PR:000006847"},{"id":"T3803","span":{"begin":214,"end":225},"obj":"SO:0000336"},{"id":"T3804","span":{"begin":234,"end":241},"obj":"SO:0000188"},{"id":"T3805","span":{"begin":318,"end":324},"obj":"SO:0000188"},{"id":"T3806","span":{"begin":330,"end":341},"obj":"SO:0000336"},{"id":"T3807","span":{"begin":445,"end":457},"obj":"SO:0000336"},{"id":"T3808","span":{"begin":475,"end":483},"obj":"SO:0000857"},{"id":"T3809","span":{"begin":487,"end":491},"obj":"PR:000006847"},{"id":"T3810","span":{"begin":628,"end":634},"obj":"SO:0000188"},{"id":"T3811","span":{"begin":640,"end":651},"obj":"SO:0000336"},{"id":"T3812","span":{"begin":703,"end":719},"obj":"SO:0000043"},{"id":"T3813","span":{"begin":763,"end":768},"obj":"SO:0000704"}],"text":"To determine the chromosomal localizations of the mouse ESG1 gene and pseudogenes, we performed a Blast analysis of the mouse genomic database with the ESG1 cDNA sequence as a query. We identified several putative pseudogenes without introns on chromosomes 1, 5, 11, 12, 14, 16, 17, and X (Figure 1). In addition, two intron-less pseudogenes were identified in DNA fragments for which the chromosomal localization remained unmapped. While these pseudodgenes have significant homology to ESG1 cDNA, they could not produce functional proteins, because of critical mutations. This result suggests that there are a larger number of intron-less pseudogenes than previously anticipated. Existence of multiple retropseudogenes is a hallmark of pluripotent cell-specific genes [18]."}

    craft-ca-core-ex-dev

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    craft-sa-dev

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determine the chromosomal localizations of the mouse ESG1 gene and pseudogenes, we performed a Blast analysis of the mouse genomic database with the ESG1 cDNA sequence as a query. We identified several putative pseudogenes without introns on chromosomes 1, 5, 11, 12, 14, 16, 17, and X (Figure 1). In addition, two intron-less pseudogenes were identified in DNA fragments for which the chromosomal localization remained unmapped. While these pseudodgenes have significant homology to ESG1 cDNA, they could not produce functional proteins, because of critical mutations. This result suggests that there are a larger number of intron-less pseudogenes than previously anticipated. Existence of multiple retropseudogenes is a hallmark of pluripotent cell-specific genes [18]."}