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PMC:1420271 / 4244-8755 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3792 43-48 NCBITaxon:10088 denotes mouse
T3793 49-53 PR:000006847 denotes ESG1
T3794 54-58 SO:0000704 denotes gene
T3795 63-73 SO:0000336 denotes psedogenes
T3796 124-129 NCBITaxon:10088 denotes mouse
T3797 130-134 PR:000006847 denotes ESG1
T3798 135-139 SO:0000704 denotes gene
T3799 144-155 SO:0000336 denotes pseudogenes
T3800 194-199 NCBITaxon:10088 denotes mouse
T3801 200-207 SO:0001026 denotes genomic
T3802 226-230 PR:000006847 denotes ESG1
T3803 288-299 SO:0000336 denotes pseudogenes
T3804 308-315 SO:0000188 denotes introns
T3805 392-398 SO:0000188 denotes intron
T3806 404-415 SO:0000336 denotes pseudogenes
T3807 519-531 SO:0000336 denotes pseudodgenes
T3808 549-557 SO:0000857 denotes homology
T3809 561-565 PR:000006847 denotes ESG1
T3810 702-708 SO:0000188 denotes intron
T3811 714-725 SO:0000336 denotes pseudogenes
T3812 777-793 SO:0000043 denotes retropseudogenes
T3813 837-842 SO:0000704 denotes genes
T3814 1152-1156 PR:000006847 denotes ESG1
T3815 1157-1161 SO:0000704 denotes gene
T3816 1189-1196 SO:0000188 denotes introns
T3817 1230-1235 SO:0000147 denotes exons
T3818 1286-1290 PR:000006847 denotes ESG1
T3819 1325-1329 SO:0000147 denotes exon
T3820 1379-1383 PR:000006847 denotes ESG1
T3821 1384-1388 SO:0000704 denotes gene
T3822 1497-1501 SO:0000147 denotes exon
T3823 1509-1513 PR:000006847 denotes ESG1
T3824 1514-1518 SO:0000704 denotes gene
T3825 1554-1558 PR:000006847 denotes ESG1
T3826 1664-1668 PR:000006847 denotes ESG1
T3827 1669-1673 SO:0000704 denotes gene
T3828 1691-1700 NCBITaxon:2 denotes bacterial
T3829 1691-1722 SO:0000153 denotes bacterial artificial chromosome
T3830 1724-1727 SO:0000153 denotes BAC
T3831 1751-1757 SO:0000112 denotes primer
T3832 1797-1801 SO:0000704 denotes gene
T3833 1811-1822 SO:0000336 denotes pseudogenes
T3834 1869-1872 SO:0000153 denotes BAC
T3835 2005-2009 PR:000006847 denotes ESG1
T3836 2052-2059 SO:0000188 denotes introns
T3837 2081-2087 SO:0000188 denotes intron
T3838 2164-2185 SO:0001421 denotes exon-intron junctions
T3876 4418-4429 SO:0000336 denotes pseudogenes
T3877 4500-4510 SO:0000336 denotes pseudogene
T12038 859-863 PR:000006847 denotes ESG1
T12039 863-874 SO:0000336 denotes pseudogenes
T12040 907-912 NCBITaxon:10088 denotes mouse
T12041 913-920 SO:0001026 denotes genomic
T12042 985-991 SO:0000188 denotes Intron
T12043 997-1000 SO:0000730 denotes gap
T12236 2536-2539 SO:0000153 denotes BAC
T12237 2562-2566 PR:000006847 denotes ESG1
T12238 2567-2571 SO:0000704 denotes gene
T12239 2590-2600 SO:0000336 denotes pseudogene
T12240 2602-2604 SO:0000336 denotes PS
T12241 2630-2634 SO:0000704 denotes gene
T12242 2639-2641 SO:0000336 denotes PS
T12243 2689-2693 SO:0000704 denotes gene
T12244 2698-2700 SO:0000336 denotes PS
T12245 2725-2735 SO:0000857 denotes homologous
T12246 2747-2757 SO:0000028 denotes base pairs
T12247 2780-2784 SO:0000147 denotes exon
T12248 2792-2794 SO:0000028 denotes bp
T12249 2819-2823 SO:0000147 denotes exon
T12508 2936-2944 SO:0000167 denotes Promoter
T12509 2945-2953 SO:0000165 denotes enhancer
T12510 2970-2974 PR:000006847 denotes ESG1
T12511 2975-2979 SO:0000704 denotes gene
T12512 2984-2994 SO:0000336 denotes pseudogene
T12513 3017-3019 SO:0000028 denotes bp
T12514 3038-3057 SO:0001416 denotes 5' flanking regions
T12515 3065-3069 SO:0000704 denotes gene
T12516 3074-3076 SO:0000336 denotes PS
T12517 3119-3127 SO:0000155 denotes plasmids
T12518 3156-3161 SO:0000704 denotes genes
T12519 3184-3192 CL:0002322 denotes ES cells
T12520 3209-3222 CHEBI:26536 denotes retinoic acid
T12521 3231-3239 CL:0002322 denotes ES cells
T3839 2196-2214 SO:0001416 denotes 5' flanking region
T3840 2253-2261 SO:0000167 denotes promoter
T3841 2262-2270 SO:0000165 denotes enhancer
T3842 2330-2338 CL:0002322 denotes ES cells
T3843 2351-2364 CL:0002371 denotes somatic cells
T3844 2461-2474 CHEBI:26536 denotes retinoic acid
T3845 2515-2519 PR:000006847 denotes ESG1
T3846 2520-2524 SO:0000704 denotes gene
T3847 3404-3407 SO:0000153 denotes BAC
T3848 3433-3437 PR:000006847 denotes ESG1
T3849 3503-3505 SO:0000028 denotes bp
T3850 3506-3525 SO:0000605 denotes intergenic sequence
T3851 3569-3573 PR:000006847 denotes ESG1
T3852 3631-3636 SO:0000147 denotes exons
T3853 3641-3648 SO:0000188 denotes introns
T3854 3656-3660 PR:000006847 denotes ESG1
T3855 3661-3665 SO:0000704 denotes gene
T3856 3749-3754 SO:0000147 denotes exons
T3857 3787-3791 SO:0000147 denotes exon
T3858 3820-3830 SO:0000028 denotes base pairs
T3859 3838-3857 SO:0001417 denotes 3' flanking regions
T3860 3885-3889 PR:000006847 denotes ESG1
T3861 3890-3894 SO:0000704 denotes gene
T3862 3903-3913 SO:0000336 denotes pseudogene
T3863 3925-3935 SO:0000028 denotes base pairs
T3864 3943-3961 SO:0001416 denotes 5' flanking region
T3865 3983-4001 SO:0001416 denotes 5' flanking region
T3866 4007-4009 SO:0000028 denotes bp
T3867 4031-4039 SO:0000167 denotes promoter
T3868 4040-4048 SO:0000165 denotes enhancer
T3869 4157-4167 GO:0006412 denotes translated
T3870 4241-4251 SO:0000336 denotes pseudogene
T3871 4303-4314 SO:0000336 denotes pseudogenes
T3872 4328-4332 SO:0000147 denotes exon
T3873 4333-4339 SO:0000188 denotes intron
T3874 4360-4364 PR:000006847 denotes ESG1
T3875 4365-4369 SO:0000704 denotes gene

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3878 0-11 GO_SO_EXT:chromosome denotes Chromosomal
T3879 12-24 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T3880 43-48 NCBITaxon:10088 denotes mouse
T3881 49-53 PR_EXT:000006847 denotes ESG1
T3894 236-244 SO_EXT:biological_sequence denotes sequence
T3895 288-299 SO_EXT:0000336 denotes pseudogenes
T3896 308-315 SO_EXT:0000188 denotes introns
T3897 319-330 GO_SO_EXT:chromosome denotes chromosomes
T3898 392-398 SO_EXT:0000188 denotes intron
T3899 404-415 SO_EXT:0000336 denotes pseudogenes
T3900 435-438 CHEBI_SO_EXT:DNA denotes DNA
T3901 463-474 GO_SO_EXT:chromosome denotes chromosomal
T3902 475-487 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T3903 519-531 SO_EXT:0000336 denotes pseudodgenes
T3904 549-557 SO:0000857 denotes homology
T3905 561-565 PR_EXT:000006847 denotes ESG1
T3906 566-570 SO_EXT:cDNA denotes cDNA
T3907 606-614 CHEBI_PR_EXT:protein denotes proteins
T3908 636-645 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3909 702-708 SO_EXT:0000188 denotes intron
T3910 714-725 SO_EXT:0000336 denotes pseudogenes
T3911 777-793 SO_EXT:0000043 denotes retropseudogenes
T3912 823-827 CL_GO_EXT:cell denotes cell
T3913 837-842 SO_EXT:0000704 denotes genes
T3914 1094-1104 GO_SO_EXT:chromosome denotes chromosome
T3915 1124-1127 CHEBI_SO_EXT:DNA denotes DNA
T3916 1152-1156 PR_EXT:000006847 denotes ESG1
T3917 1157-1161 SO_EXT:0000704 denotes gene
T3918 1189-1196 SO_EXT:0000188 denotes introns
T3919 1230-1235 SO_EXT:0000147 denotes exons
T3920 1269-1278 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3921 1286-1290 PR_EXT:000006847 denotes ESG1
T3922 1291-1295 SO_EXT:cDNA denotes cDNA
T3923 1296-1304 SO_EXT:biological_sequence denotes sequence
T3924 1325-1329 SO_EXT:0000147 denotes exon
T3925 1379-1383 PR_EXT:000006847 denotes ESG1
T3926 1384-1388 SO_EXT:0000704 denotes gene
T3927 1398-1408 GO_SO_EXT:chromosome denotes chromosome
T3928 1434-1437 CHEBI_SO_EXT:DNA denotes DNA
T3929 1497-1501 SO_EXT:0000147 denotes exon
T3930 1509-1513 PR_EXT:000006847 denotes ESG1
T3931 1514-1518 SO_EXT:0000704 denotes gene
T3932 1554-1558 PR_EXT:000006847 denotes ESG1
T3933 1564-1573 SO_EXT:biological_sequence denotes sequences
T3934 1577-1587 GO_SO_EXT:chromosome denotes chromosome
T3935 1635-1638 CHEBI_SO_EXT:DNA denotes DNA
T3936 1664-1668 PR_EXT:000006847 denotes ESG1
T3937 1669-1673 SO_EXT:0000704 denotes gene
T3938 1691-1700 NCBITaxon:2 denotes bacterial
T3939 1691-1722 SO_EXT:0000153 denotes bacterial artificial chromosome
T3940 1712-1722 GO_SO_EXT:chromosome denotes chromosome
T3941 1724-1727 SO_EXT:0000153 denotes BAC
T3942 1729-1732 CHEBI_SO_EXT:DNA denotes DNA
T3943 1751-1757 SO_EXT:0000112 denotes primer
T3944 1797-1801 SO_EXT:0000704 denotes gene
T3945 1811-1822 SO_EXT:0000336 denotes pseudogenes
T3946 1869-1872 SO_EXT:0000153 denotes BAC
T3947 1873-1879 SO_EXT:sequence_cloned_entity denotes clones
T3948 1943-1949 SO_EXT:sequence_cloned_entity denotes clones
T3949 1962-1970 SO_EXT:biological_sequence denotes sequence
T3950 2005-2009 PR_EXT:000006847 denotes ESG1
T3951 2010-2014 SO_EXT:cDNA denotes cDNA
T3952 2052-2059 SO_EXT:0000188 denotes introns
T3953 2081-2087 SO_EXT:0000188 denotes intron
T3954 2088-2097 SO_EXT:biological_sequence denotes sequences
T4017 4365-4369 SO_EXT:0000704 denotes gene
T4018 4418-4429 SO_EXT:0000336 denotes pseudogenes
T4019 4500-4510 SO_EXT:0000336 denotes pseudogene
T12044 859-863 PR_EXT:000006847 denotes ESG1
T12045 863-874 SO_EXT:0000336 denotes pseudogenes
T12046 907-912 NCBITaxon:10088 denotes mouse
T12047 913-920 SO_EXT:0001026 denotes genomic
T12048 932-944 SO_EXT:sequence_substitution_entity_or_process denotes Substitution
T12049 945-954 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12050 985-991 SO_EXT:0000188 denotes Intron
T12051 997-1000 SO_EXT:0000730 denotes gap
T12052 1001-1010 SO_EXT:biological_sequence denotes sequences
T12053 1041-1052 GO_SO_EXT:chromosome denotes Chromosomal
T12054 1053-1066 GO_PATO_EXT:biological_localization_process_or_quality denotes localizations
T12250 2536-2539 SO_EXT:0000153 denotes BAC
T12251 2540-2546 SO_EXT:sequence_cloned_entity denotes clones
T12252 2562-2566 PR_EXT:000006847 denotes ESG1
T12253 2567-2571 SO_EXT:0000704 denotes gene
T12254 2578-2589 SO_EXT:sequence_duplication_entity_or_process denotes duplication
T12255 2590-2600 SO_EXT:0000336 denotes pseudogene
T12256 2602-2604 SO_EXT:0000336 denotes PS
T12257 2610-2622 GO_PATO_EXT:biological_localization_process_or_quality denotes Localization
T12258 2630-2634 SO_EXT:0000704 denotes gene
T12259 2639-2641 SO_EXT:0000336 denotes PS
T12260 2645-2655 GO_SO_EXT:chromosome denotes chromosome
T12261 2662-2670 SO_EXT:biological_sequence denotes Sequence
T12262 2689-2693 SO_EXT:0000704 denotes gene
T12263 2698-2700 SO_EXT:0000336 denotes PS
T12264 2725-2735 SO:0000857 denotes homologous
T12265 2747-2751 CHEBI_SO_EXT:base denotes base
T12266 2747-2757 SO_EXT:0000028 denotes base pairs
T12267 2758-2766 SO_EXT:sequence_upstreamness denotes upstream
T12268 2780-2784 SO_EXT:0000147 denotes exon
T12269 2792-2794 SO_EXT:0000028 denotes bp
T12270 2795-2805 SO_EXT:sequence_downstreamness denotes downstream
T12271 2819-2823 SO_EXT:0000147 denotes exon
T12272 2825-2837 SO_EXT:sequence_substitution_entity_or_process denotes Substitution
T12273 2838-2847 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12274 2882-2891 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T12522 2936-2944 SO_EXT:0000167 denotes Promoter
T12523 2945-2953 SO_EXT:0000165 denotes enhancer
T12524 2970-2974 PR_EXT:000006847 denotes ESG1
T12525 2975-2979 SO_EXT:0000704 denotes gene
T12526 2984-2994 SO_EXT:0000336 denotes pseudogene
T12527 2996-2999 CHEBI_SO_EXT:DNA denotes DNA
T12528 3017-3019 SO_EXT:0000028 denotes bp
T12529 3038-3057 SO_EXT:0001416 denotes 5' flanking regions
T12530 3065-3069 SO_EXT:0000704 denotes gene
T12531 3074-3076 SO_EXT:0000336 denotes PS
T12532 3082-3093 GO_EXT:biological_movement_or_translocation_process denotes transferred
T12533 3099-3109 GO_EXT:0045289 denotes luciferase
T12534 3119-3127 SO_EXT:0000155 denotes plasmids
T12535 3156-3161 SO_EXT:0000704 denotes genes
T12536 3169-3183 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T12537 3184-3192 CL:0002322 denotes ES cells
T12538 3187-3192 CL_GO_EXT:cell denotes cells
T12539 3209-3222 CHEBI:26536 denotes retinoic acid
T12540 3231-3239 CL:0002322 denotes ES cells
T12541 3234-3239 CL_GO_EXT:cell denotes cells
T12542 3267-3272 CL_GO_EXT:cell denotes cells
T3969 2515-2519 PR_EXT:000006847 denotes ESG1
T3970 2520-2524 SO_EXT:0000704 denotes gene
T3971 3404-3407 SO_EXT:0000153 denotes BAC
T3992 3820-3830 SO_EXT:0000028 denotes base pairs
T3993 3838-3857 SO_EXT:0001417 denotes 3' flanking regions
T3882 54-58 SO_EXT:0000704 denotes gene
T3883 63-73 SO_EXT:0000336 denotes psedogenes
T3884 91-102 GO_SO_EXT:chromosome denotes chromosomal
T3885 103-116 GO_PATO_EXT:biological_localization_process_or_quality denotes localizations
T3886 124-129 NCBITaxon:10088 denotes mouse
T3887 130-134 PR_EXT:000006847 denotes ESG1
T3888 135-139 SO_EXT:0000704 denotes gene
T3889 144-155 SO_EXT:0000336 denotes pseudogenes
T3890 194-199 NCBITaxon:10088 denotes mouse
T3891 200-207 SO_EXT:0001026 denotes genomic
T3892 226-230 PR_EXT:000006847 denotes ESG1
T3893 231-235 SO_EXT:cDNA denotes cDNA
T3955 2164-2185 SO_EXT:0001421 denotes exon-intron junctions
T3956 2196-2214 SO_EXT:0001416 denotes 5' flanking region
T3957 2223-2226 CHEBI_SO_EXT:DNA denotes DNA
T3958 2253-2261 SO_EXT:0000167 denotes promoter
T3959 2262-2270 SO_EXT:0000165 denotes enhancer
T3960 2283-2293 GO_EXT:0045289 denotes luciferase
T3961 2315-2329 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T3962 2330-2338 CL:0002322 denotes ES cells
T3963 2333-2338 CL_GO_EXT:cell denotes cells
T3964 2351-2364 CL:0002371 denotes somatic cells
T3965 2359-2364 CL_GO_EXT:cell denotes cells
T3966 2442-2457 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3967 2461-2474 CHEBI:26536 denotes retinoic acid
T3968 2499-2507 SO_EXT:biological_sequence denotes sequence
T3972 3408-3414 SO_EXT:sequence_cloned_entity denotes clones
T3973 3433-3437 PR_EXT:000006847 denotes ESG1
T3974 3443-3451 SO_EXT:biological_sequence denotes sequence
T3975 3473-3482 SO_EXT:biological_sequence denotes sequences
T3976 3503-3505 SO_EXT:0000028 denotes bp
T3977 3506-3525 SO_EXT:0000605 denotes intergenic sequence
T3978 3569-3573 PR_EXT:000006847 denotes ESG1
T3979 3579-3587 SO_EXT:biological_sequence denotes sequence
T3980 3631-3636 SO_EXT:0000147 denotes exons
T3981 3641-3648 SO_EXT:0000188 denotes introns
T3982 3656-3660 PR_EXT:000006847 denotes ESG1
T3983 3661-3665 SO_EXT:0000704 denotes gene
T3984 3672-3680 SO_EXT:biological_sequence denotes sequence
T3985 3710-3720 CHEBI_SO_EXT:nucleotide denotes nucleotide
T3986 3721-3734 SO_EXT:sequence_substitution_entity_or_process denotes substitutions
T3987 3749-3754 SO_EXT:0000147 denotes exons
T3988 3763-3773 CHEBI_SO_EXT:nucleotide denotes nucleotide
T3989 3774-3783 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T3990 3787-3791 SO_EXT:0000147 denotes exon
T3991 3820-3824 CHEBI_SO_EXT:base denotes base
T3994 3863-3872 SO_EXT:biological_conservation_process_or_quality denotes conserved
T3995 3885-3889 PR_EXT:000006847 denotes ESG1
T3996 3890-3894 SO_EXT:0000704 denotes gene
T3997 3903-3913 SO_EXT:0000336 denotes pseudogene
T3998 3925-3929 CHEBI_SO_EXT:base denotes base
T3999 3925-3935 SO_EXT:0000028 denotes base pairs
T4000 3943-3961 SO_EXT:0001416 denotes 5' flanking region
T4001 3983-4001 SO_EXT:0001416 denotes 5' flanking region
T4002 4007-4009 SO_EXT:0000028 denotes bp
T4003 4031-4039 SO_EXT:0000167 denotes promoter
T4004 4040-4048 SO_EXT:0000165 denotes enhancer
T4005 4061-4071 GO_EXT:0045289 denotes luciferase
T4006 4130-4138 SO_EXT:biological_sequence denotes sequence
T4007 4142-4153 GO_EXT:transcription denotes transcribed
T4008 4157-4167 GO:0006412 denotes translated
T4009 4186-4193 CHEBI_PR_EXT:protein denotes protein
T4010 4200-4208 SO_EXT:biological_sequence denotes sequence
T4011 4229-4240 SO_EXT:sequence_duplication_entity_or_process denotes duplication
T4012 4241-4251 SO_EXT:0000336 denotes pseudogene
T4013 4303-4314 SO_EXT:0000336 denotes pseudogenes
T4014 4328-4332 SO_EXT:0000147 denotes exon
T4015 4333-4339 SO_EXT:0000188 denotes intron
T4016 4360-4364 PR_EXT:000006847 denotes ESG1

craft-sa-dev

Id Subject Object Predicate Lexical cue
T4020 0-11 JJ denotes Chromosomal
T4021 12-24 NN denotes localization
T4022 25-28 CC denotes and
T4023 29-39 NNS denotes structures
T4024 40-42 IN denotes of
T4025 43-48 NN denotes mouse
T4026 54-58 NN denotes gene
T4027 49-53 NN denotes ESG1
T4028 59-62 CC denotes and
T4029 63-73 NNS denotes psedogenes
T4030 73-256 sentence denotes To determine the chromosomal localizations of the mouse ESG1 gene and pseudogenes, we performed a Blast analysis of the mouse genomic database with the ESG1 cDNA sequence as a query.
T4031 74-76 TO denotes To
T4032 77-86 VB denotes determine
T4033 160-169 VBD denotes performed
T4034 87-90 DT denotes the
T4035 103-116 NNS denotes localizations
T4036 91-102 JJ denotes chromosomal
T4037 117-119 IN denotes of
T4038 120-123 DT denotes the
T4039 135-139 NN denotes gene
T4040 124-129 NN denotes mouse
T4041 130-134 NN denotes ESG1
T4042 140-143 CC denotes and
T4043 144-155 NNS denotes pseudogenes
T4044 155-157 , denotes ,
T4045 157-159 PRP denotes we
T4046 170-171 DT denotes a
T4047 178-186 NN denotes analysis
T4048 172-177 NNP denotes Blast
T4049 187-189 IN denotes of
T4050 190-193 DT denotes the
T4051 208-216 NN denotes database
T4052 194-199 NN denotes mouse
T4053 200-207 JJ denotes genomic
T4054 217-221 IN denotes with
T4055 222-225 DT denotes the
T4056 236-244 NN denotes sequence
T4057 226-230 NN denotes ESG1
T4058 231-235 NN denotes cDNA
T4059 245-247 IN denotes as
T4060 248-249 DT denotes a
T4061 250-255 NN denotes query
T4062 255-256 . denotes .
T4063 256-374 sentence denotes We identified several putative pseudogenes without introns on chromosomes 1, 5, 11, 12, 14, 16, 17, and X (Figure 1).
T4064 257-259 PRP denotes We
T4065 260-270 VBD denotes identified
T4066 271-278 JJ denotes several
T4067 288-299 NNS denotes pseudogenes
T4068 279-287 JJ denotes putative
T4069 300-307 IN denotes without
T4070 308-315 NNS denotes introns
T4071 316-318 IN denotes on
T4072 319-330 NNS denotes chromosomes
T4073 361-362 NN denotes X
T4074 331-332 CD denotes 1
T4075 332-334 , denotes ,
T4076 334-335 CD denotes 5
T4077 335-337 , denotes ,
T4078 337-339 CD denotes 11
T4079 339-341 , denotes ,
T4080 341-343 CD denotes 12
T4081 343-345 , denotes ,
T4082 345-347 CD denotes 14
T4083 347-349 , denotes ,
T4084 349-351 CD denotes 16
T4085 351-353 , denotes ,
T4086 353-355 CD denotes 17
T4087 355-357 , denotes ,
T4088 357-360 CC denotes and
T4089 363-364 -LRB- denotes (
T4090 364-370 NN denotes Figure
T4091 371-372 CD denotes 1
T4092 372-373 -RRB- denotes )
T4093 373-374 . denotes .
T4094 374-506 sentence denotes In addition, two intron-less pseudogenes were identified in DNA fragments for which the chromosomal localization remained unmapped.
T4122 558-560 IN denotes to
T4123 561-565 NN denotes ESG1
T4124 566-570 NN denotes cDNA
T4125 570-572 , denotes ,
T4126 572-576 PRP denotes they
T4127 577-582 MD denotes could
T4128 583-586 RB denotes not
T4129 595-605 JJ denotes functional
T4130 606-614 NN denotes proteins
T4131 614-616 , denotes ,
T4132 616-623 IN denotes because
T4133 624-626 IN denotes of
T4134 627-635 JJ denotes critical
T4135 636-645 NNS denotes mutations
T4136 645-646 . denotes .
T4137 646-754 sentence denotes This result suggests that there are a larger number of intron-less pseudogenes than previously anticipated.
T4138 647-651 DT denotes This
T4139 652-658 NN denotes result
T4140 659-667 VBZ denotes suggests
T4141 668-672 IN denotes that
T4142 679-682 VBP denotes are
T4143 673-678 EX denotes there
T4144 683-684 DT denotes a
T4145 692-698 NN denotes number
T4146 685-691 JJR denotes larger
T4147 699-701 IN denotes of
T4148 702-713 JJ denotes intron-less
T4149 714-725 NNS denotes pseudogenes
T4150 726-730 IN denotes than
T4151 742-753 VBN denotes anticipated
T4152 731-741 RB denotes previously
T4153 753-754 . denotes .
T4154 754-848 sentence denotes Existence of multiple retropseudogenes is a hallmark of pluripotent cell-specific genes [18].
T4155 755-764 NN denotes Existence
T4156 794-796 VBZ denotes is
T4157 765-767 IN denotes of
T4158 768-776 JJ denotes multiple
T4159 777-793 NNS denotes retropseudogenes
T4160 797-798 DT denotes a
T4161 799-807 NN denotes hallmark
T4162 808-810 IN denotes of
T4163 811-822 JJ denotes pluripotent
T4164 837-842 NNS denotes genes
T4165 823-827 NN denotes cell
T4166 828-836 JJ denotes specific
T4167 827-828 HYPH denotes -
T4168 843-844 -LRB- denotes [
T4169 844-846 CD denotes 18
T4170 846-847 -RRB- denotes ]
T4171 847-848 . denotes .
T4172 848-849 sentence denotes
T4187 1152-1156 NN denotes ESG1
T4188 1162-1166 WDT denotes that
T4189 1167-1175 VBD denotes included
T4190 1176-1179 CD denotes two
T4191 1189-1196 NNS denotes introns
T4192 1180-1188 JJ denotes putative
T4193 1196-1197 . denotes .
T4194 1197-1305 sentence denotes These putative first and second exons, however, contained (4) multiple mutations of the ESG1 cDNA sequence.
T4195 1198-1203 DT denotes These
T4196 1230-1235 NNS denotes exons
T4197 1204-1212 JJ denotes putative
T4198 1213-1218 JJ denotes first
T4199 1219-1222 CC denotes and
T4200 1223-1229 JJ denotes second
T4201 1246-1255 VBD denotes contained
T4202 1235-1237 , denotes ,
T4203 1237-1244 RB denotes however
T4204 1244-1246 , denotes ,
T4205 1256-1257 -LRB- denotes (
T4206 1257-1258 CD denotes 4
T4207 1258-1259 -RRB- denotes )
T4208 1260-1268 JJ denotes multiple
T4209 1269-1278 NNS denotes mutations
T4210 1279-1281 IN denotes of
T4211 1282-1285 DT denotes the
T4212 1296-1304 NN denotes sequence
T4213 1286-1290 NN denotes ESG1
T4214 1291-1295 NN denotes cDNA
T4215 1304-1305 . denotes .
T4216 1305-1389 sentence denotes The putative third exon was identical to that of the previously reported ESG1 gene.
T4217 1306-1309 DT denotes The
T4218 1325-1329 NN denotes exon
T4219 1310-1318 JJ denotes putative
T4220 1319-1324 JJ denotes third
T4221 1330-1333 VBD denotes was
T4222 1334-1343 JJ denotes identical
T4223 1344-1346 IN denotes to
T4224 1347-1351 DT denotes that
T4225 1352-1354 IN denotes of
T4226 1355-1358 DT denotes the
T4227 1384-1388 NN denotes gene
T4228 1359-1369 RB denotes previously
T4229 1370-1378 VBN denotes reported
T4230 1379-1383 NN denotes ESG1
T4231 1388-1389 . denotes .
T4232 1389-1519 sentence denotes Also on chromosome 9, we identified another DNA fragment that was similar, but not identical, to the third exon of the ESG1 gene.
T4233 1390-1394 RB denotes Also
T4234 1415-1425 VBD denotes identified
T4235 1395-1397 IN denotes on
T4236 1398-1408 NN denotes chromosome
T4237 1409-1410 CD denotes 9
T4238 1410-1412 , denotes ,
T4239 1412-1414 PRP denotes we
T4240 1426-1433 DT denotes another
T4241 1438-1446 NN denotes fragment
T4242 1434-1437 NN denotes DNA
T4243 1447-1451 WDT denotes that
T4244 1452-1455 VBD denotes was
T4245 1456-1463 JJ denotes similar
T4246 1463-1465 , denotes ,
T4247 1465-1468 CC denotes but
T4248 1469-1472 RB denotes not
T4249 1473-1482 JJ denotes identical
T4250 1482-1484 , denotes ,
T4251 1484-1486 IN denotes to
T4252 1487-1490 DT denotes the
T4253 1497-1501 NN denotes exon
T4254 1491-1496 JJ denotes third
T4255 1502-1504 IN denotes of
T4256 1505-1508 DT denotes the
T4257 1514-1518 NN denotes gene
T4258 1509-1513 NN denotes ESG1
T4259 1518-1519 . denotes .
T4260 1519-1624 sentence denotes These findings suggest that these ESG1-like sequences on chromosome 9 have not been correctly assembled.
T4261 1520-1525 DT denotes These
T4262 1526-1534 NNS denotes findings
T4263 1535-1542 VBP denotes suggest
T4264 1543-1547 IN denotes that
T4265 1614-1623 VBN denotes assembled
T4266 1548-1553 DT denotes these
T4267 1564-1573 NNS denotes sequences
T4268 1554-1558 NN denotes ESG1
T4269 1559-1563 JJ denotes like
T4270 1558-1559 HYPH denotes -
T4271 1574-1576 IN denotes on
T4272 1577-1587 NN denotes chromosome
T4273 1588-1589 CD denotes 9
T4274 1590-1594 VBP denotes have
T4275 1595-1598 RB denotes not
T4276 1599-1603 VBN denotes been
T4277 1604-1613 RB denotes correctly
T4278 1623-1624 . denotes .
T4279 1624-1823 sentence denotes To obtain DNA fragments containing the ESG1 gene, we screened the bacterial artificial chromosome (BAC) DNA pool by PCR using primer pairs that would only amplify the real gene, not the pseudogenes.
T4280 1625-1627 TO denotes To
T4281 1628-1634 VB denotes obtain
T4282 1678-1686 VBD denotes screened
T4283 1635-1638 NN denotes DNA
T4284 1639-1648 NNS denotes fragments
T4285 1649-1659 VBG denotes containing
T4286 1660-1663 DT denotes the
T4287 1669-1673 NN denotes gene
T4288 1664-1668 NN denotes ESG1
T4289 1673-1675 , denotes ,
T4290 1675-1677 PRP denotes we
T4291 1687-1690 DT denotes the
T4292 1733-1737 NN denotes pool
T4293 1691-1700 JJ denotes bacterial
T4294 1712-1722 NN denotes chromosome
T4295 1701-1711 JJ denotes artificial
T4296 1723-1724 -LRB- denotes (
T4297 1724-1727 NN denotes BAC
T4298 1727-1728 -RRB- denotes )
T4299 1729-1732 NN denotes DNA
T4300 1738-1740 IN denotes by
T4301 1741-1744 NN denotes PCR
T4302 1745-1750 VBG denotes using
T4303 1751-1757 NN denotes primer
T4304 1758-1763 NNS denotes pairs
T4305 1764-1768 WDT denotes that
T4306 1780-1787 VB denotes amplify
T4307 1769-1774 MD denotes would
T4308 1775-1779 RB denotes only
T4309 1788-1791 DT denotes the
T4310 1797-1801 NN denotes gene
T4311 1792-1796 JJ denotes real
T4312 1801-1803 , denotes ,
T4313 1803-1806 RB denotes not
T4314 1811-1822 NNS denotes pseudogenes
T4315 1807-1810 DT denotes the
T4316 1822-1823 . denotes .
T4317 1823-1880 sentence denotes We obtained two independent, but overlapping BAC clones.
T4318 1824-1826 PRP denotes We
T4319 1827-1835 VBD denotes obtained
T4320 1836-1839 CD denotes two
T4321 1873-1879 NNS denotes clones
T4322 1840-1851 JJ denotes independent
T4323 1851-1853 , denotes ,
T4324 1853-1856 CC denotes but
T4325 1857-1868 VBG denotes overlapping
T4326 1869-1872 NN denotes BAC
T4327 1879-1880 . denotes .
T4328 1880-2072 sentence denotes Southern blot analyses and sequencing demonstrated that these clones contained a sequence exhibiting complete identity with ESG1 cDNA that was interrupted by two putative introns (Figure 2A).
T4329 1881-1889 NNP denotes Southern
T4330 1890-1894 NN denotes blot
T4331 1919-1931 VBD denotes demonstrated
T4332 1895-1903 NNS denotes analyses
T4333 1904-1907 CC denotes and
T4334 1908-1918 NN denotes sequencing
T4335 1932-1936 IN denotes that
T4336 1950-1959 VBD denotes contained
T4337 1937-1942 DT denotes these
T4338 1943-1949 NNS denotes clones
T4339 1960-1961 DT denotes a
T4340 1962-1970 NN denotes sequence
T4341 1971-1981 VBG denotes exhibiting
T4342 1982-1990 JJ denotes complete
T4343 1991-1999 NN denotes identity
T4344 2000-2004 IN denotes with
T4345 2005-2009 NN denotes ESG1
T4346 2010-2014 NN denotes cDNA
T4347 2015-2019 WDT denotes that
T4348 2024-2035 VBN denotes interrupted
T4349 2020-2023 VBD denotes was
T4350 2036-2038 IN denotes by
T4351 2039-2042 CD denotes two
T4352 2052-2059 NNS denotes introns
T4353 2043-2051 JJ denotes putative
T4354 2060-2061 -LRB- denotes (
T4355 2068-2070 NN denotes 2A
T4356 2061-2067 NN denotes Figure
T4357 2070-2071 -RRB- denotes )
T4358 2071-2072 . denotes .
T4359 2072-2191 sentence denotes The two intron sequences begin with GT and terminate with AG, fulfilling the GT-AG rule of exon-intron junctions [19].
T4360 2073-2076 DT denotes The
T4361 2088-2097 NNS denotes sequences
T4362 2077-2080 CD denotes two
T4363 2081-2087 NN denotes intron
T4364 2098-2103 VBP denotes begin
T4365 2104-2108 IN denotes with
T4366 2109-2111 NN denotes GT
T4367 2112-2115 CC denotes and
T4368 2116-2125 VB denotes terminate
T4369 2126-2130 IN denotes with
T4395 2218-2222 DT denotes this
T4396 2227-2235 NN denotes fragment
T4397 2223-2226 NN denotes DNA
T4398 2246-2252 JJ denotes strong
T4399 2271-2279 NN denotes activity
T4400 2253-2261 NN denotes promoter
T4401 2262-2270 NN denotes enhancer
T4402 2261-2262 HYPH denotes /
T4403 2280-2282 IN denotes by
T4404 2283-2293 NN denotes luciferase
T4405 2303-2309 NNS denotes assays
T4406 2294-2302 NN denotes reporter
T4407 2310-2312 IN denotes in
T4408 2313-2329 JJ denotes undifferentiated
T4409 2333-2338 NNS denotes cells
T4410 2330-2332 NN denotes ES
T4411 2338-2340 , denotes ,
T4412 2340-2343 CC denotes but
T4413 2344-2347 RB denotes not
T4414 2348-2350 IN denotes in
T4415 2351-2358 JJ denotes somatic
T4416 2359-2364 NNS denotes cells
T4417 2365-2366 -LRB- denotes (
T4418 2366-2372 NN denotes Figure
T4419 2373-2374 CD denotes 3
T4420 2374-2375 -RRB- denotes )
T4421 2375-2376 . denotes .
T4422 2376-2475 sentence denotes The same fragment showed much weaker activity after induction of differentiation by retinoic acid.
T4423 2377-2380 DT denotes The
T4424 2386-2394 NN denotes fragment
T4425 2381-2385 JJ denotes same
T4426 2395-2401 VBD denotes showed
T4427 2402-2406 RB denotes much
T4428 2407-2413 JJR denotes weaker
T4429 2414-2422 NN denotes activity
T4430 2423-2428 IN denotes after
T4431 2429-2438 NN denotes induction
T4432 2439-2441 IN denotes of
T4433 2442-2457 NN denotes differentiation
T4434 2458-2460 IN denotes by
T4435 2461-2469 JJ denotes retinoic
T4436 2470-2474 NN denotes acid
T4437 2474-2475 . denotes .
T4438 2475-2525 sentence denotes We concluded that this sequence is the ESG1 gene.
T4439 2476-2478 PRP denotes We
T4440 2479-2488 VBD denotes concluded
T4441 2489-2493 IN denotes that
T4442 2508-2510 VBZ denotes is
T4443 2494-2498 DT denotes this
T4444 2499-2507 NN denotes sequence
T4445 2511-2514 DT denotes the
T4446 2520-2524 NN denotes gene
T4447 2515-2519 NN denotes ESG1
T4448 2524-2525 . denotes .
T4487 3563-3564 . denotes .
T4488 3564-3666 sentence denotes The ESG1-like sequence exhibited greater than 95% identity to the exons and introns of the ESG1 gene.
T4489 3565-3568 DT denotes The
T4490 3579-3587 NN denotes sequence
T4491 3569-3573 NN denotes ESG1
T4492 3574-3578 JJ denotes like
T4493 3573-3574 HYPH denotes -
T4494 3588-3597 VBD denotes exhibited
T4495 3598-3605 JJR denotes greater
T4496 3611-3613 CD denotes 95
T4497 3606-3610 IN denotes than
T4498 3613-3614 NN denotes %
T4499 3615-3623 NN denotes identity
T4500 3624-3626 IN denotes to
T4501 3627-3630 DT denotes the
T4502 3631-3636 NNS denotes exons
T4503 3637-3640 CC denotes and
T4504 3641-3648 NNS denotes introns
T4505 3649-3651 IN denotes of
T4506 3652-3655 DT denotes the
T4507 3661-3665 NN denotes gene
T4508 3656-3660 NN denotes ESG1
T4509 3665-3666 . denotes .
T4510 3666-3806 sentence denotes This sequence, however, contained critical nucleotide substitutions in all of the exons and one nucleotide insertion in exon 2 (Figure 2B).
T4511 3667-3671 DT denotes This
T4512 3672-3680 NN denotes sequence
T4513 3691-3700 VBD denotes contained
T4514 3680-3682 , denotes ,
T4515 3682-3689 RB denotes however
T4516 3689-3691 , denotes ,
T4517 3701-3709 JJ denotes critical
T4518 3721-3734 NNS denotes substitutions
T4519 3710-3720 NN denotes nucleotide
T4520 3735-3737 IN denotes in
T4521 3738-3741 DT denotes all
T4522 3742-3744 IN denotes of
T4523 3745-3748 DT denotes the
T4524 3749-3754 NNS denotes exons
T4525 3755-3758 CC denotes and
T4526 3759-3762 CD denotes one
T4527 3774-3783 NN denotes insertion
T4528 3763-3773 NN denotes nucleotide
T4529 3784-3786 IN denotes in
T4530 3787-3791 NN denotes exon
T4531 3792-3793 CD denotes 2
T4532 3794-3795 -LRB- denotes (
T4533 3802-3804 NN denotes 2B
T4534 3795-3801 NN denotes Figure
T4535 3804-3805 -RRB- denotes )
T4536 3805-3806 . denotes .
T4537 3806-3977 sentence denotes Although 675 base pairs of the 3' flanking regions were conserved between the ESG1 gene and the pseudogene, only five base pairs of the 5' flanking region were identical.
T4538 3807-3815 IN denotes Although
T4539 3863-3872 VBN denotes conserved
T4540 3816-3819 CD denotes 675
T4541 3825-3830 NNS denotes pairs
T4542 3820-3824 NN denotes base
T4543 3831-3833 IN denotes of
T4544 3834-3837 DT denotes the
T4545 3850-3857 NNS denotes regions
T4546 3838-3839 CD denotes 3
T4547 3839-3840 SYM denotes '
T4548 3841-3849 NN denotes flanking
T4549 3858-3862 VBD denotes were
T4550 3962-3966 VBD denotes were
T4551 3873-3880 IN denotes between
T4552 3881-3884 DT denotes the
T4553 3890-3894 NN denotes gene
T4554 3885-3889 NN denotes ESG1
T4555 3895-3898 CC denotes and
T4556 3899-3902 DT denotes the
T4557 3903-3913 NN denotes pseudogene
T4558 3913-3915 , denotes ,
T4559 3915-3919 RB denotes only
T4560 3930-3935 NNS denotes pairs
T4561 3920-3924 CD denotes five
T4562 3925-3929 NN denotes base
T4563 3936-3938 IN denotes of
T4564 3939-3942 DT denotes the
T4565 3955-3961 NN denotes region
T4566 3943-3944 CD denotes 5
T4567 3944-3945 SYM denotes '
T4568 3946-3954 NN denotes flanking
T4569 3967-3976 JJ denotes identical
T4570 3976-3977 . denotes .
T4571 3977-4099 sentence denotes This 5' flanking region (~6 kbp) did not possess any promoter/enhancer activity in luciferase reporter assays (Figure 3).
T4572 3978-3982 DT denotes This
T4573 3995-4001 NN denotes region
T4574 3983-3984 CD denotes 5
T4575 3984-3985 SYM denotes '
T4576 3986-3994 NN denotes flanking
T4577 4019-4026 VB denotes possess
T4578 4002-4003 -LRB- denotes (
T4579 4006-4009 NN denotes kbp
T4580 4003-4004 SYM denotes ~
T4581 4004-4005 CD denotes 6
T4582 4009-4010 -RRB- denotes )
T4583 4011-4014 VBD denotes did
T4584 4015-4018 RB denotes not
T4585 4027-4030 DT denotes any
T4586 4049-4057 NN denotes activity
T4587 4031-4039 NN denotes promoter
T4588 4040-4048 NN denotes enhancer
T4589 4039-4040 HYPH denotes /
T4590 4058-4060 IN denotes in
T4591 4061-4071 NN denotes luciferase
T4592 4072-4080 NN denotes reporter
T4593 4081-4087 NNS denotes assays
T4594 4088-4089 -LRB- denotes (
T4595 4089-4095 NN denotes Figure
T4596 4096-4097 CD denotes 3
T4597 4097-4098 -RRB- denotes )
T4598 4098-4099 . denotes .
T4599 4099-4194 sentence denotes It is thus unlikely that this sequence is transcribed or translated into a functional protein.
T4600 4100-4102 PRP denotes It
T4601 4103-4105 VBZ denotes is
T4602 4106-4110 RB denotes thus
T4603 4111-4119 JJ denotes unlikely
T4604 4120-4124 IN denotes that
T4605 4142-4153 VBN denotes transcribed
T4606 4125-4129 DT denotes this
T4607 4130-4138 NN denotes sequence
T4608 4139-4141 VBZ denotes is
T4609 4154-4156 CC denotes or
T4610 4157-4167 VBN denotes translated
T4611 4168-4172 IN denotes into
T4612 4173-4174 DT denotes a
T4613 4186-4193 NN denotes protein
T4614 4175-4185 JJ denotes functional
T4615 4193-4194 . denotes .
T4616 4194-4252 sentence denotes This sequence likely represents a duplication pseudogene.
T4617 4195-4199 DT denotes This
T4618 4200-4208 NN denotes sequence
T4619 4216-4226 VBZ denotes represents
T4620 4209-4215 RB denotes likely
T4621 4227-4228 DT denotes a
T4622 4241-4251 NN denotes pseudogene
T4623 4229-4240 NN denotes duplication
T4624 4251-4252 . denotes .
T4625 4252-4375 sentence denotes Bierbaum previously reported the existence of two pseudogenes with similar exon-intron organization as the ESG1 gene [17].
T4626 4253-4261 NN denotes Bierbaum
T4627 4273-4281 VBD denotes reported
T4628 4262-4272 RB denotes previously
T4629 4282-4285 DT denotes the
T4630 4286-4295 NN denotes existence
T4631 4296-4298 IN denotes of
T4632 4299-4302 CD denotes two
T4633 4303-4314 NNS denotes pseudogenes
T4634 4315-4319 IN denotes with
T4635 4320-4327 JJ denotes similar
T4636 4340-4352 NN denotes organization
T4637 4328-4332 NN denotes exon
T4638 4333-4339 NN denotes intron
T4639 4332-4333 HYPH denotes -
T4640 4353-4355 IN denotes as
T4641 4356-4359 DT denotes the
T4642 4365-4369 NN denotes gene
T4643 4360-4364 NN denotes ESG1
T4644 4370-4371 -LRB- denotes [
T4645 4371-4373 CD denotes 17
T4646 4373-4374 -RRB- denotes ]
T4647 4374-4375 . denotes .
T4648 4375-4511 sentence denotes We could not determine which of these two pseudogenes corresponds to the one we identified or the location of the remaining pseudogene.
T4649 4376-4378 PRP denotes We
T4650 4389-4398 VB denotes determine
T4651 4379-4384 MD denotes could
T4652 4385-4388 RB denotes not
T4653 4399-4404 WDT denotes which
T4654 4430-4441 VBZ denotes corresponds
T4655 4405-4407 IN denotes of
T4656 4408-4413 DT denotes these
T4657 4418-4429 NNS denotes pseudogenes
T4658 4414-4417 CD denotes two
T4659 4442-4444 IN denotes to
T4660 4445-4448 DT denotes the
T4661 4449-4452 CD denotes one
T4662 4453-4455 PRP denotes we
T4663 4456-4466 VBD denotes identified
T4664 4467-4469 CC denotes or
T4665 4470-4473 DT denotes the
T4666 4474-4482 NN denotes location
T4667 4483-4485 IN denotes of
T4668 4486-4489 DT denotes the
T4669 4500-4510 NN denotes pseudogene
T4670 4490-4499 VBG denotes remaining
T4671 4510-4511 . denotes .
T12055 859-874 NNS denotes ESG1pseudogenes
T12056 875-885 VBN denotes identified
T12057 886-888 IN denotes by
T12058 889-890 DT denotes a
T12059 897-903 NN denotes search
T12060 891-896 NNP denotes Blast
T12061 904-906 IN denotes of
T12062 907-912 NN denotes mouse
T12063 921-930 NNS denotes databases
T12064 913-920 JJ denotes genomic
T12065 930-931 . denotes .
T12066 931-984 sentence denotes Substitution mutations are indicated by black lines.
T12067 932-944 NN denotes Substitution
T12068 945-954 NNS denotes mutations
T12069 959-968 VBN denotes indicated
T12070 955-958 VBP denotes are
T12071 969-971 IN denotes by
T12072 972-977 JJ denotes black
T12073 978-983 NNS denotes lines
T12074 983-984 . denotes .
T12075 984-1040 sentence denotes Intron-like gap sequences are indicated with triangles.
T12076 985-991 NN denotes Intron
T12077 992-996 JJ denotes like
T12078 991-992 HYPH denotes -
T12079 1001-1010 NNS denotes sequences
T12080 997-1000 NN denotes gap
T12081 1015-1024 VBN denotes indicated
T12082 1011-1014 VBP denotes are
T12083 1025-1029 IN denotes with
T12084 1030-1039 NNS denotes triangles
T12085 1039-1040 . denotes .
T12086 1040-1090 sentence denotes Chromosomal localizations are shown on the right.
T12087 1041-1052 JJ denotes Chromosomal
T12088 1053-1066 NNS denotes localizations
T12089 1071-1076 VBN denotes shown
T12090 1067-1070 VBP denotes are
T12091 1077-1079 IN denotes on
T12092 1080-1083 DT denotes the
T12093 1084-1089 NN denotes right
T12094 1089-1090 . denotes .
T12275 2536-2539 NN denotes BAC
T12276 2540-2546 NNS denotes clones
T12277 2547-2557 VBG denotes containing
T12278 2558-2561 DT denotes the
T12279 2567-2571 NN denotes gene
T12280 2562-2566 NN denotes ESG1
T12281 2572-2575 CC denotes and
T12282 2576-2577 DT denotes a
T12283 2590-2600 NN denotes pseudogene
T12284 2578-2589 NN denotes duplication
T12285 2601-2602 -LRB- denotes (
T12286 2602-2604 NN denotes PS
T12287 2604-2605 -RRB- denotes )
T12288 2605-2606 . denotes .
T12289 2606-2658 sentence denotes A) Localization of the gene and PS on chromosome 9.
T12290 2607-2608 LS denotes A
T12291 2610-2622 NN denotes Localization
T12292 2608-2609 -RRB- denotes )
T12293 2623-2625 IN denotes of
T12294 2626-2629 DT denotes the
T12295 2630-2634 NN denotes gene
T12296 2635-2638 CC denotes and
T12297 2639-2641 NN denotes PS
T12298 2642-2644 IN denotes on
T12299 2645-2655 NN denotes chromosome
T12300 2656-2657 CD denotes 9
T12301 2657-2658 . denotes .
T12302 2658-2824 sentence denotes B) Sequence comparison of the gene and PS revealed that these are homologous from eight base pairs upstream of the first exon to 675 bp downstream of the third exon.
T12303 2659-2660 LS denotes B
T12304 2701-2709 VBD denotes revealed
T12305 2660-2661 -RRB- denotes )
T12306 2662-2670 NN denotes Sequence
T12307 2671-2681 NN denotes comparison
T12308 2682-2684 IN denotes of
T12309 2685-2688 DT denotes the
T12310 2689-2693 NN denotes gene
T12311 2694-2697 CC denotes and
T12312 2698-2700 NN denotes PS
T12313 2710-2714 IN denotes that
T12314 2721-2724 VBP denotes are
T12315 2715-2720 DT denotes these
T12316 2725-2735 JJ denotes homologous
T12317 2736-2740 IN denotes from
T12318 2741-2746 CD denotes eight
T12319 2752-2757 NNS denotes pairs
T12320 2747-2751 NN denotes base
T12321 2758-2766 RB denotes upstream
T12322 2767-2769 IN denotes of
T12323 2770-2773 DT denotes the
T12324 2780-2784 NN denotes exon
T12325 2774-2779 JJ denotes first
T12326 2785-2787 IN denotes to
T12327 2788-2791 CD denotes 675
T12328 2792-2794 NN denotes bp
T12329 2795-2805 RB denotes downstream
T12330 2806-2808 IN denotes of
T12331 2809-2812 DT denotes the
T12332 2819-2823 NN denotes exon
T12333 2813-2818 JJ denotes third
T12334 2823-2824 . denotes .
T12335 2824-2877 sentence denotes Substitution mutations are indicated by black lines.
T12336 2825-2837 NN denotes Substitution
T12337 2838-2847 NNS denotes mutations
T12338 2852-2861 VBN denotes indicated
T12339 2848-2851 VBP denotes are
T12340 2862-2864 IN denotes by
T12341 2865-2870 JJ denotes black
T12342 2871-2876 NNS denotes lines
T12343 2876-2877 . denotes .
T12344 2877-2925 sentence denotes The insertion is indicated by an open triangle.
T12345 2878-2881 DT denotes The
T12346 2882-2891 NN denotes insertion
T12347 2895-2904 VBN denotes indicated
T12348 2892-2894 VBZ denotes is
T12349 2905-2907 IN denotes by
T12350 2908-2910 DT denotes an
T12351 2916-2924 NN denotes triangle
T12352 2911-2915 JJ denotes open
T12353 2924-2925 . denotes .
T12543 2936-2944 NN denotes Promoter
T12544 2945-2953 NN denotes enhancer
T12545 2944-2945 HYPH denotes /
T12546 2954-2962 NN denotes activity
T12547 2963-2965 IN denotes of
T12548 2966-2969 DT denotes the
T12549 2975-2979 NN denotes gene
T12550 2970-2974 NN denotes ESG1
T12551 2980-2983 CC denotes and
T12552 2984-2994 NN denotes pseudogene
T12553 2994-2995 . denotes .
T12554 2995-3128 sentence denotes DNA fragments of ~6 kbp isolated from the 5' flanking regions of the gene and PS were transferred into luciferase reporter plasmids.
T12555 2996-2999 NN denotes DNA
T12556 3000-3009 NNS denotes fragments
T12557 3082-3093 VBN denotes transferred
T12558 3010-3012 IN denotes of
T12559 3013-3014 SYM denotes ~
T12560 3014-3015 CD denotes 6
T12561 3016-3019 NN denotes kbp
T12562 3020-3028 VBN denotes isolated
T12563 3029-3033 IN denotes from
T12564 3034-3037 DT denotes the
T12565 3050-3057 NNS denotes regions
T12566 3038-3039 CD denotes 5
T12567 3039-3040 SYM denotes '
T12568 3041-3049 NN denotes flanking
T12569 3058-3060 IN denotes of
T12570 3061-3064 DT denotes the
T12571 3065-3069 NN denotes gene
T12572 3070-3073 CC denotes and
T12573 3074-3076 NN denotes PS
T12574 3077-3081 VBD denotes were
T12575 3094-3098 IN denotes into
T12576 3099-3109 NN denotes luciferase
T12577 3110-3118 NN denotes reporter
T12578 3119-3127 NNS denotes plasmids
T12579 3127-3128 . denotes .
T12580 3128-3290 sentence denotes We introduced the reporter genes into undifferentiated ES cells (open columns), retinoic acid-treated ES cells (grey columns), and NIH3T3 cells (closed columns).
T12581 3129-3131 PRP denotes We
T12582 3132-3142 VBD denotes introduced
T12583 3143-3146 DT denotes the
T12584 3156-3161 NNS denotes genes
T12585 3147-3155 NN denotes reporter
T12586 3162-3166 IN denotes into
T12587 3167-3183 JJ denotes undifferentiated
T12588 3187-3192 NNS denotes cells
T12589 3184-3186 NN denotes ES
T12590 3193-3194 -LRB- denotes (
T12591 3199-3206 NNS denotes columns
T12592 3194-3198 JJ denotes open
T12593 3206-3207 -RRB- denotes )
T12594 3207-3209 , denotes ,
T12595 3209-3217 JJ denotes retinoic
T12596 3218-3222 NN denotes acid
T12597 3223-3230 VBN denotes treated
T12598 3222-3223 HYPH denotes -
T12599 3234-3239 NNS denotes cells
T12600 3231-3233 NN denotes ES
T12601 3240-3241 -LRB- denotes (
T12602 3246-3253 NNS denotes columns
T12603 3241-3245 JJ denotes grey
T12604 3253-3254 -RRB- denotes )
T12605 3254-3256 , denotes ,
T12606 3256-3259 CC denotes and
T12607 3260-3266 NN denotes NIH3T3
T12608 3267-3272 NNS denotes cells
T12609 3273-3274 -LRB- denotes (
T12610 3281-3288 NNS denotes columns
T12611 3274-3280 VBN denotes closed
T12612 3288-3289 -RRB- denotes )
T12613 3289-3290 . denotes .
T12614 3290-3376 sentence denotes Data represent the averages and standard deviations of three independent experiments.
T12615 3291-3295 NNS denotes Data
T12616 3296-3305 VBP denotes represent
T12617 3306-3309 DT denotes the
T12618 3310-3318 NNS denotes averages
T12619 3319-3322 CC denotes and
T12620 3323-3331 JJ denotes standard
T12621 3332-3342 NNS denotes deviations
T12622 3343-3345 IN denotes of
T12623 3346-3351 CD denotes three
T12624 3364-3375 NNS denotes experiments
T12625 3352-3363 JJ denotes independent
T12626 3375-3376 . denotes .
T4103 432-434 IN denotes in
T4104 435-438 NN denotes DNA
T4105 439-448 NNS denotes fragments
T4106 449-452 IN denotes for
T4107 488-496 VBD denotes remained
T4108 453-458 WDT denotes which
T4109 459-462 DT denotes the
T4110 475-487 NN denotes localization
T4111 463-474 JJ denotes chromosomal
T4112 497-505 JJ denotes unmapped
T4113 505-506 . denotes .
T4114 506-646 sentence denotes While these pseudodgenes have significant homology to ESG1 cDNA, they could not produce functional proteins, because of critical mutations.
T4115 507-512 IN denotes While
T4116 532-536 VBP denotes have
T4117 513-518 DT denotes these
T4118 519-531 NNS denotes pseudodgenes
T4119 587-594 VB denotes produce
T4120 537-548 JJ denotes significant
T4121 549-557 NN denotes homology
T4183 1137-1144 JJ denotes similar
T4184 1145-1147 IN denotes to
T4185 1148-1151 DT denotes the
T4186 1157-1161 NN denotes gene
T4386 2190-2191 . denotes .
T4387 2191-2376 sentence denotes The 5' flanking region of this DNA fragment exhibited strong promoter/enhancer activity by luciferase reporter assays in undifferentiated ES cells, but not in somatic cells (Figure 3).
T4388 2192-2195 DT denotes The
T4389 2208-2214 NN denotes region
T4390 2196-2197 CD denotes 5
T4391 2197-2198 SYM denotes '
T4392 2199-2207 NN denotes flanking
T4393 2236-2245 VBD denotes exhibited
T4394 2215-2217 IN denotes of
T4477 3497-3498 DT denotes a
T4478 3517-3525 NN denotes sequence
T4479 3499-3501 CD denotes 68
T4480 3502-3505 NN denotes kbp
T4481 3506-3516 JJ denotes intergenic
T4482 3525-3527 , denotes ,
T4483 3527-3531 VBD denotes were
T4484 3541-3543 IN denotes in
T4485 3544-3552 JJ denotes opposite
T4486 3553-3563 NNS denotes directions
T4095 375-377 IN denotes In
T4096 421-431 VBN denotes identified
T4097 378-386 NN denotes addition
T4098 386-388 , denotes ,
T4099 388-391 CD denotes two
T4100 404-415 NNS denotes pseudogenes
T4101 392-403 JJ denotes intron-less
T4102 416-420 VBD denotes were
T4173 1091-1197 sentence denotes On chromosome 9, we identified a DNA fragment similar to the ESG1 gene that included two putative introns.
T4174 1091-1093 IN denotes On
T4175 1111-1121 VBD denotes identified
T4176 1094-1104 NN denotes chromosome
T4177 1105-1106 CD denotes 9
T4178 1106-1108 , denotes ,
T4179 1108-1110 PRP denotes we
T4180 1122-1123 DT denotes a
T4181 1128-1136 NN denotes fragment
T4182 1124-1127 NN denotes DNA
T4370 2131-2133 NN denotes AG
T4371 2133-2135 , denotes ,
T4372 2135-2145 VBG denotes fulfilling
T4373 2146-2149 DT denotes the
T4374 2156-2160 NN denotes rule
T4375 2150-2152 NN denotes GT
T4376 2153-2155 NN denotes AG
T4377 2152-2153 HYPH denotes -
T4378 2161-2163 IN denotes of
T4379 2164-2168 NN denotes exon
T4380 2169-2175 NN denotes intron
T4381 2168-2169 HYPH denotes -
T4382 2176-2185 NNS denotes junctions
T4383 2186-2187 -LRB- denotes [
T4384 2187-2189 CD denotes 19
T4385 2189-2190 -RRB- denotes ]
T4449 2525-3464 sentence denotes Figure 2 BAC clones containing the ESG1 gene and a duplication pseudogene (PS). A) Localization of the gene and PS on chromosome 9. B) Sequence comparison of the gene and PS revealed that these are homologous from eight base pairs upstream of the first exon to 675 bp downstream of the third exon. Substitution mutations are indicated by black lines. The insertion is indicated by an open triangle. Figure 3 Promoter/enhancer activity of the ESG1 gene and pseudogene. DNA fragments of ~6 kbp isolated from the 5' flanking regions of the gene and PS were transferred into luciferase reporter plasmids. We introduced the reporter genes into undifferentiated ES cells (open columns), retinoic acid-treated ES cells (grey columns), and NIH3T3 cells (closed columns). Data represent the averages and standard deviations of three independent experiments. We also found that the two BAC clones contained another ESG1-like sequence (Figure 2A).
T4450 3377-3379 PRP denotes We
T4451 3385-3390 VBD denotes found
T4452 3380-3384 RB denotes also
T4453 3391-3395 IN denotes that
T4454 3415-3424 VBD denotes contained
T4455 3396-3399 DT denotes the
T4456 3408-3414 NNS denotes clones
T4457 3400-3403 CD denotes two
T4458 3404-3407 NN denotes BAC
T4459 3425-3432 DT denotes another
T4460 3443-3451 NN denotes sequence
T4461 3433-3437 NN denotes ESG1
T4462 3438-3442 JJ denotes like
T4463 3437-3438 HYPH denotes -
T4464 3452-3453 -LRB- denotes (
T4465 3460-3462 NN denotes 2A
T4466 3453-3459 NN denotes Figure
T4467 3462-3463 -RRB- denotes )
T4468 3463-3464 . denotes .
T4469 3464-3564 sentence denotes The two sequences, separated by a 68 kbp intergenic sequence, were oriented in opposite directions.
T4470 3465-3468 DT denotes The
T4471 3473-3482 NNS denotes sequences
T4472 3469-3472 CD denotes two
T4473 3532-3540 VBN denotes oriented
T4474 3482-3484 , denotes ,
T4475 3484-3493 VBN denotes separated
T4476 3494-3496 IN denotes by
R734 T4020 T4021 amod Chromosomal,localization
R735 T4022 T4021 cc and,localization
R736 T4023 T4021 conj structures,localization
R737 T4024 T4021 prep of,localization
R738 T4025 T4026 compound mouse,gene
R739 T4026 T4024 pobj gene,of
R740 T4027 T4026 compound ESG1,gene
R741 T4028 T4026 cc and,gene
R742 T4029 T4026 conj psedogenes,gene
R743 T4031 T4032 aux To,determine
R744 T4032 T4033 advcl determine,performed
R745 T4034 T4035 det the,localizations
R746 T4035 T4032 dobj localizations,determine
R747 T4036 T4035 amod chromosomal,localizations
R748 T4037 T4035 prep of,localizations
R749 T4038 T4039 det the,gene
R750 T4039 T4037 pobj gene,of
R751 T4040 T4039 compound mouse,gene
R752 T4041 T4039 compound ESG1,gene
R753 T4042 T4039 cc and,gene
R754 T4043 T4039 conj pseudogenes,gene
R755 T4044 T4033 punct ", ",performed
R756 T4045 T4033 nsubj we,performed
R757 T4046 T4047 det a,analysis
R758 T4047 T4033 dobj analysis,performed
R759 T4048 T4047 compound Blast,analysis
R760 T4049 T4047 prep of,analysis
R761 T4050 T4051 det the,database
R762 T4051 T4049 pobj database,of
R763 T4052 T4051 nmod mouse,database
R764 T4053 T4051 amod genomic,database
R765 T4054 T4033 prep with,performed
R766 T4055 T4056 det the,sequence
R767 T4056 T4054 pobj sequence,with
R768 T4057 T4056 compound ESG1,sequence
R769 T4058 T4056 compound cDNA,sequence
R770 T4059 T4056 prep as,sequence
R771 T4060 T4061 det a,query
R772 T4061 T4059 pobj query,as
R773 T4062 T4033 punct .,performed
R774 T4064 T4065 nsubj We,identified
R775 T4066 T4067 amod several,pseudogenes
R776 T4067 T4065 dobj pseudogenes,identified
R777 T4068 T4067 amod putative,pseudogenes
R778 T4069 T4067 prep without,pseudogenes
R779 T4070 T4069 pobj introns,without
R780 T4071 T4065 prep on,identified
R781 T4072 T4073 nmod chromosomes,X
R782 T4073 T4071 pobj X,on
R783 T4074 T4073 nummod 1,X
R784 T4075 T4073 punct ", ",X
R785 T4076 T4073 nummod 5,X
R786 T4077 T4073 punct ", ",X
R787 T4078 T4073 nummod 11,X
R788 T4079 T4073 punct ", ",X
R789 T4080 T4073 nummod 12,X
R790 T4081 T4073 punct ", ",X
R791 T4082 T4073 nummod 14,X
R792 T4083 T4073 punct ", ",X
R793 T4084 T4073 nummod 16,X
R794 T4085 T4073 punct ", ",X
R795 T4086 T4073 nummod 17,X
R796 T4087 T4073 punct ", ",X
R797 T4088 T4073 cc and,X
R798 T4089 T4090 punct (,Figure
R799 T4090 T4065 parataxis Figure,identified
R800 T4091 T4090 nummod 1,Figure
R801 T4092 T4090 punct ),Figure
R802 T4093 T4065 punct .,identified
R803 T4095 T4096 prep In,identified
R804 T4097 T4095 pobj addition,In
R805 T4098 T4096 punct ", ",identified
R806 T4099 T4100 nummod two,pseudogenes
R807 T4100 T4096 nsubjpass pseudogenes,identified
R808 T4101 T4100 amod intron-less,pseudogenes
R809 T4102 T4096 auxpass were,identified
R810 T4103 T4096 prep in,identified
R811 T4104 T4105 compound DNA,fragments
R812 T4105 T4103 pobj fragments,in
R813 T4106 T4107 prep for,remained
R814 T4107 T4105 relcl remained,fragments
R815 T4108 T4106 pobj which,for
R816 T4109 T4110 det the,localization
R817 T4110 T4107 nsubj localization,remained
R818 T4111 T4110 amod chromosomal,localization
R819 T4112 T4107 acomp unmapped,remained
R820 T4113 T4096 punct .,identified
R821 T4115 T4116 mark While,have
R822 T4116 T4119 advcl have,produce
R823 T4117 T4118 det these,pseudodgenes
R824 T4118 T4116 nsubj pseudodgenes,have
R825 T4120 T4121 amod significant,homology
R826 T4121 T4116 dobj homology,have
R827 T4122 T4121 prep to,homology
R862 T4161 T4156 attr hallmark,is
R863 T4162 T4161 prep of,hallmark
R864 T4163 T4164 amod pluripotent,genes
R865 T4164 T4162 pobj genes,of
R866 T4165 T4166 npadvmod cell,specific
R867 T4166 T4164 amod specific,genes
R868 T4167 T4166 punct -,specific
R869 T4168 T4169 punct [,18
R870 T4169 T4161 parataxis 18,hallmark
R871 T4170 T4169 punct ],18
R872 T4171 T4156 punct .,is
R873 T4174 T4175 prep On,identified
R874 T4176 T4174 pobj chromosome,On
R875 T4177 T4176 nummod 9,chromosome
R876 T4178 T4175 punct ", ",identified
R877 T4179 T4175 nsubj we,identified
R878 T4180 T4181 det a,fragment
R879 T4181 T4175 dobj fragment,identified
R880 T4182 T4181 compound DNA,fragment
R881 T4183 T4181 amod similar,fragment
R882 T4184 T4183 prep to,similar
R883 T4185 T4186 det the,gene
R884 T4186 T4184 pobj gene,to
R885 T4187 T4186 compound ESG1,gene
R886 T4188 T4189 dep that,included
R887 T4189 T4186 relcl included,gene
R888 T4190 T4191 nummod two,introns
R889 T4191 T4189 dobj introns,included
R890 T4192 T4191 amod putative,introns
R891 T4193 T4175 punct .,identified
R892 T4195 T4196 det These,exons
R893 T4196 T4201 nsubj exons,contained
R894 T4197 T4196 amod putative,exons
R895 T4198 T4196 amod first,exons
R896 T4199 T4198 cc and,first
R897 T4200 T4198 conj second,first
R898 T4202 T4201 punct ", ",contained
R899 T4203 T4201 advmod however,contained
R900 T4204 T4201 punct ", ",contained
R901 T4205 T4206 punct (,4
R902 T4206 T4201 parataxis 4,contained
R903 T4207 T4206 punct ),4
R904 T4208 T4209 amod multiple,mutations
R905 T4209 T4201 dobj mutations,contained
R906 T4210 T4209 prep of,mutations
R907 T4211 T4212 det the,sequence
R908 T4212 T4210 pobj sequence,of
R909 T4213 T4212 compound ESG1,sequence
R910 T4214 T4212 compound cDNA,sequence
R911 T4215 T4201 punct .,contained
R912 T4217 T4218 det The,exon
R913 T4218 T4221 nsubj exon,was
R914 T4219 T4218 amod putative,exon
R915 T4220 T4218 amod third,exon
R916 T4222 T4221 acomp identical,was
R917 T4223 T4222 prep to,identical
R918 T4224 T4223 pobj that,to
R919 T4225 T4224 prep of,that
R920 T4226 T4227 det the,gene
R921 T4227 T4225 pobj gene,of
R922 T4228 T4229 advmod previously,reported
R923 T4229 T4227 amod reported,gene
R924 T4230 T4227 compound ESG1,gene
R925 T4231 T4221 punct .,was
R926 T4233 T4234 advmod Also,identified
R927 T4235 T4234 prep on,identified
R928 T4236 T4235 pobj chromosome,on
R929 T4237 T4236 nummod 9,chromosome
R930 T4238 T4234 punct ", ",identified
R931 T4239 T4234 nsubj we,identified
R932 T4240 T4241 det another,fragment
R933 T4241 T4234 dobj fragment,identified
R934 T4242 T4241 compound DNA,fragment
R935 T4243 T4244 dep that,was
R936 T4244 T4241 relcl was,fragment
R937 T4245 T4244 acomp similar,was
R938 T4246 T4245 punct ", ",similar
R939 T4247 T4245 cc but,similar
R940 T4248 T4247 neg not,but
R941 T4249 T4245 conj identical,similar
R942 T4250 T4249 punct ", ",identical
R943 T4251 T4249 conj to,identical
R944 T4252 T4253 det the,exon
R945 T4253 T4251 pobj exon,to
R946 T4254 T4253 amod third,exon
R947 T4255 T4253 prep of,exon
R948 T4256 T4257 det the,gene
R949 T4257 T4255 pobj gene,of
R950 T4258 T4257 compound ESG1,gene
R951 T4259 T4234 punct .,identified
R952 T4261 T4262 det These,findings
R953 T4262 T4263 nsubj findings,suggest
R954 T4264 T4265 mark that,assembled
R955 T4265 T4263 ccomp assembled,suggest
R956 T4266 T4267 det these,sequences
R957 T4267 T4265 nsubjpass sequences,assembled
R958 T4268 T4269 npadvmod ESG1,like
R959 T4269 T4267 amod like,sequences
R960 T4270 T4269 punct -,like
R961 T4271 T4267 prep on,sequences
R962 T4272 T4271 pobj chromosome,on
R963 T4273 T4272 nummod 9,chromosome
R964 T4274 T4265 aux have,assembled
R965 T4275 T4265 neg not,assembled
R966 T4276 T4265 auxpass been,assembled
R967 T4277 T4265 advmod correctly,assembled
R968 T4278 T4263 punct .,suggest
R969 T4280 T4281 aux To,obtain
R970 T4281 T4282 advcl obtain,screened
R971 T4283 T4284 compound DNA,fragments
R972 T4284 T4281 dobj fragments,obtain
R973 T4285 T4284 acl containing,fragments
R974 T4286 T4287 det the,gene
R975 T4287 T4285 dobj gene,containing
R976 T4288 T4287 compound ESG1,gene
R977 T4289 T4282 punct ", ",screened
R978 T4290 T4282 nsubj we,screened
R979 T4291 T4292 det the,pool
R980 T4292 T4282 dobj pool,screened
R981 T4293 T4294 amod bacterial,chromosome
R982 T4294 T4292 nmod chromosome,pool
R983 T4295 T4294 amod artificial,chromosome
R984 T4296 T4294 punct (,chromosome
R985 T4297 T4294 appos BAC,chromosome
R986 T4298 T4292 punct ),pool
R987 T4299 T4292 compound DNA,pool
R988 T4300 T4282 prep by,screened
R989 T4301 T4300 pobj PCR,by
R990 T4302 T4282 advcl using,screened
R991 T4303 T4304 compound primer,pairs
R992 T4304 T4302 dobj pairs,using
R993 T4305 T4306 dep that,amplify
R994 T4306 T4304 relcl amplify,pairs
R995 T4307 T4306 aux would,amplify
R996 T4308 T4306 advmod only,amplify
R997 T4309 T4310 det the,gene
R998 T4310 T4306 dobj gene,amplify
R999 T4311 T4310 amod real,gene
R1000 T4312 T4306 punct ", ",amplify
R1001 T4313 T4314 neg not,pseudogenes
R1002 T4314 T4306 dep pseudogenes,amplify
R1003 T4315 T4314 det the,pseudogenes
R1004 T4316 T4282 punct .,screened
R1005 T4318 T4319 nsubj We,obtained
R1006 T4320 T4321 nummod two,clones
R1007 T4321 T4319 dobj clones,obtained
R1008 T4322 T4321 amod independent,clones
R1009 T4323 T4322 punct ", ",independent
R1010 T4324 T4322 cc but,independent
R1011 T4325 T4322 conj overlapping,independent
R1012 T4326 T4321 compound BAC,clones
R1013 T4327 T4319 punct .,obtained
R1014 T4329 T4330 compound Southern,blot
R1015 T4330 T4331 nsubj blot,demonstrated
R1016 T4332 T4330 appos analyses,blot
R1017 T4333 T4332 cc and,analyses
R1018 T4334 T4332 conj sequencing,analyses
R1019 T4335 T4336 mark that,contained
R1020 T4336 T4331 ccomp contained,demonstrated
R1021 T4337 T4338 det these,clones
R1022 T4338 T4336 nsubj clones,contained
R1023 T4339 T4340 det a,sequence
R1024 T4340 T4336 dobj sequence,contained
R1025 T4341 T4340 acl exhibiting,sequence
R1026 T4342 T4343 amod complete,identity
R1027 T4343 T4341 dobj identity,exhibiting
R1028 T4344 T4343 prep with,identity
R1029 T4345 T4346 compound ESG1,cDNA
R1030 T4346 T4344 pobj cDNA,with
R1031 T4347 T4348 dep that,interrupted
R1032 T4348 T4340 relcl interrupted,sequence
R1033 T4349 T4348 auxpass was,interrupted
R1034 T4350 T4348 agent by,interrupted
R1035 T4351 T4352 nummod two,introns
R1036 T4352 T4350 pobj introns,by
R1037 T4353 T4352 amod putative,introns
R1038 T4354 T4355 punct (,2A
R1039 T4355 T4348 parataxis 2A,interrupted
R1040 T4356 T4355 compound Figure,2A
R1041 T4357 T4355 punct ),2A
R1042 T4358 T4331 punct .,demonstrated
R1043 T4360 T4361 det The,sequences
R1044 T4361 T4364 nsubj sequences,begin
R1045 T4362 T4361 nummod two,sequences
R1046 T4363 T4361 compound intron,sequences
R1047 T4365 T4364 prep with,begin
R1048 T4366 T4365 pobj GT,with
R1049 T4367 T4364 cc and,begin
R1050 T4368 T4364 conj terminate,begin
R1051 T4369 T4368 prep with,terminate
R1052 T4370 T4369 pobj AG,with
R1053 T4371 T4364 punct ", ",begin
R1054 T4372 T4364 advcl fulfilling,begin
R1055 T4373 T4374 det the,rule
R1056 T4374 T4372 dobj rule,fulfilling
R1057 T4375 T4376 compound GT,AG
R1058 T4376 T4374 compound AG,rule
R1059 T4377 T4376 punct -,AG
R1060 T4378 T4374 prep of,rule
R1061 T4379 T4380 compound exon,intron
R1062 T4380 T4382 compound intron,junctions
R1063 T4381 T4380 punct -,intron
R1064 T4382 T4378 pobj junctions,of
R1065 T4383 T4384 punct [,19
R1066 T4384 T4372 parataxis 19,fulfilling
R1067 T4385 T4384 punct ],19
R1068 T4386 T4364 punct .,begin
R1069 T4388 T4389 det The,region
R1070 T4389 T4393 nsubj region,exhibited
R1071 T4390 T4389 nummod 5,region
R1072 T4391 T4390 punct ',5
R1073 T4392 T4389 compound flanking,region
R1074 T4394 T4389 prep of,region
R1075 T4395 T4396 det this,fragment
R1076 T4396 T4394 pobj fragment,of
R1077 T4397 T4396 compound DNA,fragment
R1078 T4398 T4399 amod strong,activity
R1079 T4399 T4393 dobj activity,exhibited
R1080 T4400 T4401 compound promoter,enhancer
R1081 T4401 T4399 compound enhancer,activity
R1082 T4402 T4401 punct /,enhancer
R1083 T4403 T4393 prep by,exhibited
R1084 T4404 T4405 compound luciferase,assays
R1085 T4405 T4403 pobj assays,by
R1086 T4406 T4405 compound reporter,assays
R1087 T4407 T4393 prep in,exhibited
R1088 T4408 T4409 amod undifferentiated,cells
R1089 T4409 T4407 pobj cells,in
R1090 T4410 T4409 compound ES,cells
R1091 T4411 T4407 punct ", ",in
R1092 T4412 T4407 cc but,in
R1093 T4413 T4412 neg not,but
R1094 T4414 T4407 conj in,in
R1095 T4415 T4416 amod somatic,cells
R1096 T4416 T4414 pobj cells,in
R1097 T4417 T4418 punct (,Figure
R1098 T4418 T4393 parataxis Figure,exhibited
R1099 T4419 T4418 nummod 3,Figure
R1100 T4420 T4418 punct ),Figure
R1101 T4421 T4393 punct .,exhibited
R1102 T4423 T4424 det The,fragment
R1103 T4424 T4426 nsubj fragment,showed
R1104 T4425 T4424 amod same,fragment
R1105 T4427 T4428 advmod much,weaker
R1106 T4428 T4429 amod weaker,activity
R1107 T4429 T4426 dobj activity,showed
R1108 T4430 T4426 prep after,showed
R1109 T4431 T4430 pobj induction,after
R1110 T4432 T4431 prep of,induction
R1111 T4433 T4432 pobj differentiation,of
R1112 T4434 T4431 prep by,induction
R1113 T4435 T4436 amod retinoic,acid
R1114 T4436 T4434 pobj acid,by
R1115 T4437 T4426 punct .,showed
R1116 T4439 T4440 nsubj We,concluded
R1117 T4441 T4442 mark that,is
R1125 T4515 T4513 advmod however,contained
R1126 T4516 T4513 punct ", ",contained
R1127 T4517 T4518 amod critical,substitutions
R1128 T4518 T4513 dobj substitutions,contained
R1129 T4519 T4518 compound nucleotide,substitutions
R1130 T4520 T4513 prep in,contained
R1131 T4521 T4520 pobj all,in
R1132 T4522 T4521 prep of,all
R1133 T4523 T4524 det the,exons
R1134 T4524 T4522 pobj exons,of
R1135 T4525 T4513 cc and,contained
R1136 T4526 T4527 nummod one,insertion
R1137 T4527 T4513 conj insertion,contained
R1138 T4528 T4527 compound nucleotide,insertion
R1139 T4529 T4527 prep in,insertion
R1140 T4530 T4529 pobj exon,in
R1142 T4531 T4530 nummod 2,exon
R1143 T4532 T4533 punct (,2B
R1146 T4533 T4527 parataxis 2B,insertion
R1147 T4534 T4533 compound Figure,2B
R1148 T4454 T4451 ccomp contained,found
R1149 T4535 T4533 punct ),2B
R1151 T4456 T4454 nsubj clones,contained
R1152 T4536 T4513 punct .,contained
R1155 T4459 T4460 det another,sequence
R1156 T4460 T4454 dobj sequence,contained
R1157 T4461 T4462 npadvmod ESG1,like
R1158 T4462 T4460 amod like,sequence
R1159 T4538 T4539 mark Although,conserved
R1160 T4463 T4462 punct -,like
R1161 T4464 T4465 punct (,2A
R1162 T4465 T4454 parataxis 2A,contained
R1163 T4539 T4550 advcl conserved,were
R1164 T4466 T4465 compound Figure,2A
R1165 T4467 T4465 punct ),2A
R1166 T4468 T4451 punct .,found
R1167 T4540 T4541 nummod 675,pairs
R1168 T4470 T4471 det The,sequences
R1169 T4471 T4473 nsubjpass sequences,oriented
R1170 T4541 T4539 nsubjpass pairs,conserved
R1171 T4472 T4471 nummod two,sequences
R1172 T4474 T4471 punct ", ",sequences
R1173 T4542 T4541 compound base,pairs
R1174 T4475 T4471 acl separated,sequences
R1175 T4476 T4475 agent by,separated
R1176 T4543 T4541 prep of,pairs
R1177 T4477 T4478 det a,sequence
R1178 T4478 T4476 pobj sequence,by
R1179 T4479 T4480 nummod 68,kbp
R1180 T4544 T4545 det the,regions
R1181 T4480 T4478 nmod kbp,sequence
R1182 T4481 T4478 amod intergenic,sequence
R1183 T4545 T4543 pobj regions,of
R1184 T4482 T4473 punct ", ",oriented
R1185 T4546 T4545 nummod 3,regions
R1186 T4483 T4473 auxpass were,oriented
R1187 T4484 T4473 prep in,oriented
R1188 T4485 T4486 amod opposite,directions
R1189 T4486 T4484 pobj directions,in
R1190 T4487 T4473 punct .,oriented
R1191 T4547 T4546 punct ',3
R1192 T4489 T4490 det The,sequence
R1193 T4490 T4494 nsubj sequence,exhibited
R1194 T4548 T4545 compound flanking,regions
R1195 T4491 T4492 npadvmod ESG1,like
R1196 T4492 T4490 amod like,sequence
R1197 T4493 T4492 punct -,like
R1198 T4549 T4539 auxpass were,conserved
R1199 T4495 T4496 amod greater,95
R1200 T4496 T4498 nummod 95,%
R1201 T4551 T4539 prep between,conserved
R1202 T4497 T4496 quantmod than,95
R1203 T4498 T4499 compound %,identity
R1204 T4499 T4494 dobj identity,exhibited
R1205 T4500 T4499 prep to,identity
R1206 T4552 T4553 det the,gene
R1207 T4501 T4502 det the,exons
R1208 T4502 T4500 pobj exons,to
R1209 T4503 T4502 cc and,exons
R1210 T4504 T4502 conj introns,exons
R1211 T4505 T4502 prep of,exons
R1212 T4553 T4551 pobj gene,between
R1213 T4506 T4507 det the,gene
R1214 T4507 T4505 pobj gene,of
R1215 T4508 T4507 compound ESG1,gene
R1216 T4554 T4553 compound ESG1,gene
R1217 T4509 T4494 punct .,exhibited
R1218 T4511 T4512 det This,sequence
R1219 T4555 T4553 cc and,gene
R1220 T4512 T4513 nsubj sequence,contained
R1221 T4556 T4557 det the,pseudogene
R1222 T4514 T4513 punct ", ",contained
R1223 T4557 T4553 conj pseudogene,gene
R1224 T4558 T4550 punct ", ",were
R1225 T4559 T4560 advmod only,pairs
R1226 T4621 T4622 det a,pseudogene
R1227 T4560 T4550 nsubj pairs,were
R1228 T4622 T4619 dobj pseudogene,represents
R1229 T4623 T4622 compound duplication,pseudogene
R1230 T4624 T4619 punct .,represents
R1231 T4561 T4560 nummod five,pairs
R1232 T4626 T4627 nsubj Bierbaum,reported
R1233 T4562 T4560 compound base,pairs
R1234 T4628 T4627 advmod previously,reported
R1235 T4629 T4630 det the,existence
R1236 T4563 T4560 prep of,pairs
R1237 T4630 T4627 dobj existence,reported
R1238 T4631 T4630 prep of,existence
R1239 T4632 T4633 nummod two,pseudogenes
R1240 T4564 T4565 det the,region
R1241 T4633 T4631 pobj pseudogenes,of
R1242 T4565 T4563 pobj region,of
R1243 T4634 T4633 prep with,pseudogenes
R1244 T4566 T4565 nummod 5,region
R1245 T4635 T4636 amod similar,organization
R1246 T4567 T4566 punct ',5
R1247 T4636 T4634 pobj organization,with
R1248 T4637 T4638 compound exon,intron
R1249 T4568 T4565 compound flanking,region
R1250 T4638 T4636 compound intron,organization
R1251 T4639 T4638 punct -,intron
R1252 T4640 T4627 prep as,reported
R1253 T4569 T4550 acomp identical,were
R1254 T4641 T4642 det the,gene
R1255 T4642 T4640 pobj gene,as
R1256 T4643 T4642 compound ESG1,gene
R1257 T4570 T4550 punct .,were
R1258 T4644 T4645 punct [,17
R1259 T4645 T4627 parataxis 17,reported
R1260 T4646 T4645 punct ],17
R1261 T4647 T4627 punct .,reported
R1262 T4572 T4573 det This,region
R1263 T4649 T4650 nsubj We,determine
R1264 T4651 T4650 aux could,determine
R1265 T4573 T4577 nsubj region,possess
R1266 T4652 T4650 neg not,determine
R1267 T4653 T4654 dep which,corresponds
R1268 T4654 T4650 ccomp corresponds,determine
R1269 T4574 T4573 nummod 5,region
R1270 T4655 T4653 prep of,which
R1271 T4656 T4657 det these,pseudogenes
R1272 T4575 T4574 punct ',5
R1273 T4657 T4655 pobj pseudogenes,of
R1274 T4658 T4657 nummod two,pseudogenes
R1275 T4576 T4573 compound flanking,region
R1276 T4659 T4654 prep to,corresponds
R1277 T4660 T4661 det the,one
R1278 T4661 T4659 pobj one,to
R1279 T4578 T4579 punct (,kbp
R1280 T4662 T4663 nsubj we,identified
R1281 T4663 T4661 advcl identified,one
R1282 T4664 T4661 cc or,one
R1283 T4665 T4666 det the,location
R1284 T4579 T4573 parataxis kbp,region
R1285 T4666 T4661 conj location,one
R1286 T4667 T4666 prep of,location
R1287 T4668 T4669 det the,pseudogene
R1288 T4580 T4581 punct ~,6
R1289 T4669 T4667 pobj pseudogene,of
R1290 T4670 T4669 amod remaining,pseudogene
R1291 T4671 T4650 punct .,determine
R1292 T4581 T4579 nummod 6,kbp
R1293 T4582 T4579 punct ),kbp
R1294 T4583 T4577 aux did,possess
R1295 T4584 T4577 neg not,possess
R1296 T4585 T4586 det any,activity
R1297 T4586 T4577 dobj activity,possess
R1298 T4587 T4588 compound promoter,enhancer
R1299 T4588 T4586 compound enhancer,activity
R1300 T4589 T4588 punct /,enhancer
R1301 T4590 T4577 prep in,possess
R1302 T4591 T4592 compound luciferase,reporter
R1303 T4592 T4593 compound reporter,assays
R1304 T4593 T4590 pobj assays,in
R1305 T4594 T4595 punct (,Figure
R1306 T4595 T4577 parataxis Figure,possess
R1307 T4596 T4595 nummod 3,Figure
R1308 T4597 T4595 punct ),Figure
R1309 T4598 T4577 punct .,possess
R1310 T4600 T4601 nsubj It,is
R1311 T4602 T4601 advmod thus,is
R1312 T4603 T4601 acomp unlikely,is
R1313 T4604 T4605 mark that,transcribed
R1314 T4605 T4601 ccomp transcribed,is
R1315 T4606 T4607 det this,sequence
R1316 T4607 T4605 nsubjpass sequence,transcribed
R1317 T4608 T4605 auxpass is,transcribed
R1318 T4609 T4605 cc or,transcribed
R1319 T4610 T4605 conj translated,transcribed
R1320 T4611 T4610 prep into,translated
R1321 T4612 T4613 det a,protein
R1322 T4613 T4611 pobj protein,into
R1323 T4614 T4613 amod functional,protein
R1324 T4615 T4601 punct .,is
R1325 T4617 T4618 det This,sequence
R1326 T4618 T4619 nsubj sequence,represents
R1327 T4620 T4619 advmod likely,represents
R3462 T12056 T12055 acl identified,ESG1pseudogenes
R3463 T12057 T12056 agent by,identified
R3464 T12058 T12059 det a,search
R3465 T12059 T12057 pobj search,by
R3466 T12060 T12059 compound Blast,search
R3467 T12061 T12059 prep of,search
R3468 T12062 T12063 nmod mouse,databases
R3469 T12063 T12061 pobj databases,of
R3470 T12064 T12063 amod genomic,databases
R3471 T12065 T12055 punct .,ESG1pseudogenes
R3472 T12067 T12068 compound Substitution,mutations
R3473 T12068 T12069 nsubjpass mutations,indicated
R3474 T12070 T12069 auxpass are,indicated
R3475 T12071 T12069 agent by,indicated
R3476 T12072 T12073 amod black,lines
R3477 T12073 T12071 pobj lines,by
R3478 T12074 T12069 punct .,indicated
R3479 T12076 T12077 npadvmod Intron,like
R3480 T12077 T12079 amod like,sequences
R3481 T12078 T12077 punct -,like
R3482 T12079 T12081 nsubjpass sequences,indicated
R3483 T12080 T12079 compound gap,sequences
R3484 T12082 T12081 auxpass are,indicated
R3485 T12083 T12081 prep with,indicated
R3486 T12084 T12083 pobj triangles,with
R3487 T12085 T12081 punct .,indicated
R3488 T12087 T12088 amod Chromosomal,localizations
R3489 T12088 T12089 nsubjpass localizations,shown
R3490 T12090 T12089 auxpass are,shown
R3491 T12091 T12089 prep on,shown
R3492 T12092 T12093 det the,right
R3493 T12093 T12091 pobj right,on
R3494 T12094 T12089 punct .,shown
R3495 T12275 T12276 compound BAC,clones
R3496 T12276 T12277 nsubj clones,containing
R3497 T12278 T12279 det the,gene
R3498 T12279 T12277 dobj gene,containing
R3499 T12280 T12279 compound ESG1,gene
R3500 T12281 T12279 cc and,gene
R3501 T12282 T12283 det a,pseudogene
R3502 T12283 T12279 conj pseudogene,gene
R3503 T12284 T12283 compound duplication,pseudogene
R3504 T12285 T12286 punct (,PS
R3505 T12286 T12283 parataxis PS,pseudogene
R3506 T12287 T12286 punct ),PS
R3507 T12288 T12277 punct .,containing
R3508 T12290 T12291 meta A,Localization
R3509 T12292 T12290 punct ),A
R3510 T12293 T12291 prep of,Localization
R3511 T12294 T12295 det the,gene
R3512 T12295 T12293 pobj gene,of
R3513 T12296 T12295 cc and,gene
R3514 T12297 T12295 conj PS,gene
R3515 T12298 T12291 prep on,Localization
R3516 T12299 T12298 pobj chromosome,on
R3517 T12300 T12299 nummod 9,chromosome
R3518 T12301 T12291 punct .,Localization
R3519 T12303 T12304 meta B,revealed
R3520 T12305 T12303 punct ),B
R3521 T12306 T12307 compound Sequence,comparison
R3522 T12307 T12304 nsubj comparison,revealed
R3523 T12308 T12307 prep of,comparison
R3524 T12309 T12310 det the,gene
R3525 T12310 T12308 pobj gene,of
R3526 T12311 T12310 cc and,gene
R3527 T12312 T12310 conj PS,gene
R3528 T12313 T12314 mark that,are
R3529 T12314 T12304 ccomp are,revealed
R3530 T12315 T12314 nsubj these,are
R3531 T12316 T12314 acomp homologous,are
R3532 T12317 T12316 prep from,homologous
R3533 T12318 T12319 nummod eight,pairs
R3534 T12319 T12317 pobj pairs,from
R3535 T12320 T12319 compound base,pairs
R3536 T12321 T12319 advmod upstream,pairs
R3537 T12322 T12321 prep of,upstream
R3538 T12323 T12324 det the,exon
R3539 T12324 T12322 pobj exon,of
R3540 T12325 T12324 amod first,exon
R3541 T12326 T12317 prep to,from
R3542 T12327 T12328 nummod 675,bp
R3543 T12328 T12326 pobj bp,to
R3544 T12329 T12328 advmod downstream,bp
R3545 T12330 T12329 prep of,downstream
R3546 T12331 T12332 det the,exon
R3547 T12332 T12330 pobj exon,of
R3548 T12333 T12332 amod third,exon
R3549 T12334 T12304 punct .,revealed
R3550 T12336 T12337 compound Substitution,mutations
R3551 T12337 T12338 nsubjpass mutations,indicated
R3552 T12339 T12338 auxpass are,indicated
R3553 T12340 T12338 prep by,indicated
R3554 T12341 T12342 amod black,lines
R3555 T12342 T12340 pobj lines,by
R3556 T12343 T12338 punct .,indicated
R3557 T12345 T12346 det The,insertion
R3558 T12346 T12347 nsubjpass insertion,indicated
R3559 T12348 T12347 auxpass is,indicated
R3560 T12349 T12347 prep by,indicated
R3561 T12350 T12351 det an,triangle
R3562 T12351 T12349 pobj triangle,by
R3563 T12352 T12351 amod open,triangle
R3564 T12353 T12347 punct .,indicated
R3565 T12543 T12544 compound Promoter,enhancer
R3566 T12544 T12546 compound enhancer,activity
R3567 T12545 T12544 punct /,enhancer
R3568 T12547 T12546 prep of,activity
R3569 T12548 T12549 det the,gene
R3570 T12549 T12547 pobj gene,of
R3571 T12550 T12549 compound ESG1,gene
R3572 T12551 T12549 cc and,gene
R3573 T12552 T12549 conj pseudogene,gene
R3574 T12553 T12546 punct .,activity
R3575 T12555 T12556 compound DNA,fragments
R3576 T12556 T12557 nsubjpass fragments,transferred
R3577 T12558 T12556 prep of,fragments
R3578 T12559 T12560 punct ~,6
R3579 T12560 T12561 nummod 6,kbp
R3580 T12561 T12558 pobj kbp,of
R3581 T12562 T12561 acl isolated,kbp
R3582 T12563 T12562 prep from,isolated
R3583 T12564 T12565 det the,regions
R3584 T12565 T12563 pobj regions,from
R3585 T12566 T12565 nummod 5,regions
R3586 T12567 T12566 punct ',5
R3587 T12568 T12565 compound flanking,regions
R3588 T12569 T12565 prep of,regions
R3589 T12570 T12571 det the,gene
R3590 T12571 T12569 pobj gene,of
R3591 T12572 T12571 cc and,gene
R3592 T12573 T12571 conj PS,gene
R3593 T12574 T12557 auxpass were,transferred
R3594 T12575 T12557 prep into,transferred
R3595 T12576 T12577 compound luciferase,reporter
R3596 T12577 T12578 compound reporter,plasmids
R3597 T12578 T12575 pobj plasmids,into
R3598 T12579 T12557 punct .,transferred
R3599 T12581 T12582 nsubj We,introduced
R3600 T12583 T12584 det the,genes
R3601 T12584 T12582 dobj genes,introduced
R3602 T12585 T12584 compound reporter,genes
R3603 T12586 T12582 prep into,introduced
R3604 T12587 T12588 amod undifferentiated,cells
R3605 T12588 T12586 pobj cells,into
R3606 T12589 T12588 compound ES,cells
R3607 T12590 T12591 punct (,columns
R3608 T12591 T12588 parataxis columns,cells
R3609 T12592 T12591 amod open,columns
R3610 T12593 T12591 punct ),columns
R3611 T12594 T12588 punct ", ",cells
R3612 T12595 T12596 amod retinoic,acid
R3613 T12596 T12597 npadvmod acid,treated
R3614 T12597 T12599 amod treated,cells
R3615 T12598 T12597 punct -,treated
R3616 T12599 T12588 conj cells,cells
R3617 T12600 T12599 compound ES,cells
R3618 T12601 T12602 punct (,columns
R3619 T12602 T12599 parataxis columns,cells
R3620 T12603 T12602 amod grey,columns
R3621 T12604 T12602 punct ),columns
R3622 T12605 T12599 punct ", ",cells
R3623 T12606 T12599 cc and,cells
R3624 T12607 T12608 compound NIH3T3,cells
R3625 T12608 T12599 conj cells,cells
R3626 T12609 T12610 punct (,columns
R3627 T12610 T12608 parataxis columns,cells
R3628 T12611 T12610 amod closed,columns
R3629 T12612 T12610 punct ),columns
R3630 T12613 T12582 punct .,introduced
R3631 T12615 T12616 nsubj Data,represent
R3632 T12617 T12618 det the,averages
R3633 T12618 T12616 dobj averages,represent
R3634 T12619 T12618 cc and,averages
R3635 T12620 T12621 amod standard,deviations
R3636 T12621 T12618 conj deviations,averages
R3637 T12622 T12618 prep of,averages
R3638 T12623 T12624 nummod three,experiments
R3639 T12624 T12622 pobj experiments,of
R3640 T12625 T12624 amod independent,experiments
R3641 T12626 T12616 punct .,represent
R828 T4123 T4124 compound ESG1,cDNA
R829 T4124 T4122 pobj cDNA,to
R830 T4125 T4119 punct ", ",produce
R831 T4126 T4119 nsubj they,produce
R832 T4127 T4119 aux could,produce
R833 T4128 T4119 neg not,produce
R834 T4129 T4130 amod functional,proteins
R835 T4130 T4119 dobj proteins,produce
R836 T4131 T4119 punct ", ",produce
R837 T4132 T4119 prep because,produce
R838 T4133 T4132 pcomp of,because
R839 T4134 T4135 amod critical,mutations
R840 T4135 T4132 pobj mutations,because
R841 T4136 T4119 punct .,produce
R842 T4138 T4139 det This,result
R843 T4139 T4140 nsubj result,suggests
R844 T4141 T4142 mark that,are
R845 T4142 T4140 ccomp are,suggests
R846 T4143 T4142 expl there,are
R847 T4144 T4145 det a,number
R848 T4145 T4142 attr number,are
R849 T4146 T4145 amod larger,number
R850 T4147 T4145 prep of,number
R851 T4148 T4149 amod intron-less,pseudogenes
R852 T4149 T4147 pobj pseudogenes,of
R853 T4150 T4151 mark than,anticipated
R854 T4151 T4145 advcl anticipated,number
R855 T4152 T4151 advmod previously,anticipated
R856 T4153 T4140 punct .,suggests
R857 T4155 T4156 nsubj Existence,is
R858 T4157 T4155 prep of,Existence
R859 T4158 T4159 amod multiple,retropseudogenes
R860 T4159 T4157 pobj retropseudogenes,of
R861 T4160 T4161 det a,hallmark
R1118 T4442 T4440 ccomp is,concluded
R1119 T4443 T4444 det this,sequence
R1120 T4444 T4442 nsubj sequence,is
R1121 T4445 T4446 det the,gene
R1122 T4446 T4442 attr gene,is
R1123 T4447 T4446 compound ESG1,gene
R1124 T4448 T4440 punct .,concluded
R1141 T4450 T4451 nsubj We,found
R1144 T4452 T4451 advmod also,found
R1145 T4453 T4454 mark that,contained
R1150 T4455 T4456 det the,clones
R1153 T4457 T4456 nummod two,clones
R1154 T4458 T4456 compound BAC,clones