PMC:1420271 / 13744-14069
Annnotations
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T6221","span":{"begin":18,"end":26},"obj":"CL:0002322"},{"id":"T6222","span":{"begin":32,"end":43},"obj":"UBERON:0000358"},{"id":"T6223","span":{"begin":72,"end":76},"obj":"PR:000006847"},{"id":"T6224","span":{"begin":90,"end":94},"obj":"PR:000006847"},{"id":"T6225","span":{"begin":120,"end":127},"obj":"CL:0002322"},{"id":"T6226","span":{"begin":163,"end":167},"obj":"PR:000006847"},{"id":"T6227","span":{"begin":178,"end":182},"obj":"PR:000006847"},{"id":"T6228","span":{"begin":188,"end":196},"obj":"CL:0002322"},{"id":"T6229","span":{"begin":229,"end":242},"obj":"GO:0008283"},{"id":"T6230","span":{"begin":293,"end":297},"obj":"PR:000006847"},{"id":"T6231","span":{"begin":316,"end":324},"obj":"CL:0002322"}],"text":"We also generated ES cells from blastocysts obtained by intercrosses of ESG1+/- males and ESG1-/- females. Of the eight ES cell lines established, two clones were ESG1-/-. These ESG1-null ES cells demonstrated normal morphology, proliferation, and differentiation (not shown), confirming that ESG1 is dispensable in ES cells."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6411","span":{"begin":18,"end":26},"obj":"CL:0002322"},{"id":"T6412","span":{"begin":21,"end":26},"obj":"CL_GO_EXT:cell"},{"id":"T6413","span":{"begin":32,"end":43},"obj":"UBERON:0000358"},{"id":"T6414","span":{"begin":72,"end":76},"obj":"PR_EXT:000006847"},{"id":"T6415","span":{"begin":76,"end":77},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T6416","span":{"begin":78,"end":79},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6417","span":{"begin":80,"end":85},"obj":"PATO_UBERON_EXT:male_or_bearer_of_maleness"},{"id":"T6418","span":{"begin":90,"end":94},"obj":"PR_EXT:000006847"},{"id":"T6419","span":{"begin":94,"end":95},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6420","span":{"begin":96,"end":97},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6421","span":{"begin":98,"end":105},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T6422","span":{"begin":120,"end":127},"obj":"CL:0002322"},{"id":"T6423","span":{"begin":123,"end":127},"obj":"CL_GO_EXT:cell"},{"id":"T6424","span":{"begin":151,"end":157},"obj":"SO_EXT:sequence_cloned_entity"},{"id":"T6425","span":{"begin":163,"end":167},"obj":"PR_EXT:000006847"},{"id":"T6426","span":{"begin":167,"end":168},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6427","span":{"begin":169,"end":170},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6428","span":{"begin":178,"end":182},"obj":"PR_EXT:000006847"},{"id":"T6429","span":{"begin":183,"end":187},"obj":"SO_EXT:sequence_nullness"},{"id":"T6430","span":{"begin":188,"end":196},"obj":"CL:0002322"},{"id":"T6431","span":{"begin":191,"end":196},"obj":"CL_GO_EXT:cell"},{"id":"T6432","span":{"begin":229,"end":242},"obj":"GO:0008283"},{"id":"T6433","span":{"begin":248,"end":263},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T6434","span":{"begin":293,"end":297},"obj":"PR_EXT:000006847"},{"id":"T6435","span":{"begin":316,"end":324},"obj":"CL:0002322"},{"id":"T6436","span":{"begin":319,"end":324},"obj":"CL_GO_EXT:cell"}],"text":"We also generated ES cells from blastocysts obtained by intercrosses of ESG1+/- males and ESG1-/- females. Of the eight ES cell lines established, two clones were ESG1-/-. These ESG1-null ES cells demonstrated normal morphology, proliferation, and differentiation (not shown), confirming that ESG1 is dispensable in ES cells."}
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T7138","span":{"begin":0,"end":2},"obj":"PRP"},{"id":"T7139","span":{"begin":8,"end":17},"obj":"VBD"},{"id":"T7140","span":{"begin":3,"end":7},"obj":"RB"},{"id":"T7141","span":{"begin":18,"end":20},"obj":"NN"},{"id":"T7142","span":{"begin":21,"end":26},"obj":"NNS"},{"id":"T7143","span":{"begin":27,"end":31},"obj":"IN"},{"id":"T7144","span":{"begin":32,"end":43},"obj":"NNS"},{"id":"T7145","span":{"begin":44,"end":52},"obj":"VBN"},{"id":"T7146","span":{"begin":53,"end":55},"obj":"IN"},{"id":"T7147","span":{"begin":56,"end":68},"obj":"NNS"},{"id":"T7148","span":{"begin":69,"end":71},"obj":"IN"},{"id":"T7149","span":{"begin":72,"end":76},"obj":"NN"},{"id":"T7150","span":{"begin":80,"end":85},"obj":"NNS"},{"id":"T7151","span":{"begin":76,"end":77},"obj":"SYM"},{"id":"T7152","span":{"begin":77,"end":78},"obj":"HYPH"},{"id":"T7153","span":{"begin":78,"end":79},"obj":"SYM"},{"id":"T7154","span":{"begin":86,"end":89},"obj":"CC"},{"id":"T7155","span":{"begin":90,"end":94},"obj":"NN"},{"id":"T7156","span":{"begin":98,"end":105},"obj":"NNS"},{"id":"T7157","span":{"begin":94,"end":95},"obj":"SYM"},{"id":"T7158","span":{"begin":95,"end":96},"obj":"HYPH"},{"id":"T7159","span":{"begin":96,"end":97},"obj":"SYM"},{"id":"T7160","span":{"begin":105,"end":106},"obj":"."},{"id":"T7161","span":{"begin":106,"end":171},"obj":"sentence"},{"id":"T7162","span":{"begin":107,"end":109},"obj":"IN"},{"id":"T7163","span":{"begin":158,"end":162},"obj":"VBD"},{"id":"T7164","span":{"begin":110,"end":113},"obj":"DT"},{"id":"T7165","span":{"begin":128,"end":133},"obj":"NNS"},{"id":"T7166","span":{"begin":114,"end":119},"obj":"CD"},{"id":"T7167","span":{"begin":120,"end":122},"obj":"NN"},{"id":"T7168","span":{"begin":123,"end":127},"obj":"NN"},{"id":"T7169","span":{"begin":134,"end":145},"obj":"VBN"},{"id":"T7170","span":{"begin":145,"end":147},"obj":","},{"id":"T7171","span":{"begin":147,"end":150},"obj":"CD"},{"id":"T7172","span":{"begin":151,"end":157},"obj":"NNS"},{"id":"T7173","span":{"begin":163,"end":167},"obj":"NN"},{"id":"T7174","span":{"begin":167,"end":168},"obj":"SYM"},{"id":"T7175","span":{"begin":168,"end":169},"obj":"HYPH"},{"id":"T7176","span":{"begin":169,"end":170},"obj":"SYM"},{"id":"T7177","span":{"begin":170,"end":171},"obj":"."},{"id":"T7178","span":{"begin":171,"end":325},"obj":"sentence"},{"id":"T7179","span":{"begin":172,"end":177},"obj":"DT"},{"id":"T7180","span":{"begin":191,"end":196},"obj":"NNS"},{"id":"T7181","span":{"begin":178,"end":182},"obj":"NN"},{"id":"T7182","span":{"begin":183,"end":187},"obj":"JJ"},{"id":"T7183","span":{"begin":182,"end":183},"obj":"HYPH"},{"id":"T7184","span":{"begin":188,"end":190},"obj":"NN"},{"id":"T7185","span":{"begin":197,"end":209},"obj":"VBD"},{"id":"T7186","span":{"begin":210,"end":216},"obj":"JJ"},{"id":"T7187","span":{"begin":217,"end":227},"obj":"NN"},{"id":"T7188","span":{"begin":227,"end":229},"obj":","},{"id":"T7189","span":{"begin":229,"end":242},"obj":"NN"},{"id":"T7190","span":{"begin":242,"end":244},"obj":","},{"id":"T7191","span":{"begin":244,"end":247},"obj":"CC"},{"id":"T7192","span":{"begin":248,"end":263},"obj":"NN"},{"id":"T7193","span":{"begin":264,"end":265},"obj":"-LRB-"},{"id":"T7194","span":{"begin":269,"end":274},"obj":"VBN"},{"id":"T7195","span":{"begin":265,"end":268},"obj":"RB"},{"id":"T7196","span":{"begin":274,"end":275},"obj":"-RRB-"},{"id":"T7197","span":{"begin":275,"end":277},"obj":","},{"id":"T7198","span":{"begin":277,"end":287},"obj":"VBG"},{"id":"T7199","span":{"begin":288,"end":292},"obj":"IN"},{"id":"T7200","span":{"begin":298,"end":300},"obj":"VBZ"},{"id":"T7201","span":{"begin":293,"end":297},"obj":"NN"},{"id":"T7202","span":{"begin":301,"end":312},"obj":"JJ"},{"id":"T7203","span":{"begin":313,"end":315},"obj":"IN"},{"id":"T7204","span":{"begin":316,"end":318},"obj":"NN"},{"id":"T7205","span":{"begin":319,"end":324},"obj":"NNS"},{"id":"T7206","span":{"begin":324,"end":325},"obj":"."}],"relations":[{"id":"R1915","pred":"nsubj","subj":"T7138","obj":"T7139"},{"id":"R1917","pred":"advmod","subj":"T7140","obj":"T7139"},{"id":"R1918","pred":"compound","subj":"T7141","obj":"T7142"},{"id":"R1919","pred":"dobj","subj":"T7142","obj":"T7139"},{"id":"R1921","pred":"prep","subj":"T7143","obj":"T7139"},{"id":"R1922","pred":"pobj","subj":"T7144","obj":"T7143"},{"id":"R1923","pred":"acl","subj":"T7145","obj":"T7144"},{"id":"R1924","pred":"prep","subj":"T7146","obj":"T7145"},{"id":"R1926","pred":"pobj","subj":"T7147","obj":"T7146"},{"id":"R1927","pred":"prep","subj":"T7148","obj":"T7147"},{"id":"R1929","pred":"nmod","subj":"T7149","obj":"T7150"},{"id":"R1931","pred":"pobj","subj":"T7150","obj":"T7148"},{"id":"R1932","pred":"punct","subj":"T7151","obj":"T7149"},{"id":"R1933","pred":"punct","subj":"T7152","obj":"T7149"},{"id":"R1934","pred":"punct","subj":"T7153","obj":"T7149"},{"id":"R1936","pred":"cc","subj":"T7154","obj":"T7150"},{"id":"R1937","pred":"nmod","subj":"T7155","obj":"T7156"},{"id":"R1939","pred":"conj","subj":"T7156","obj":"T7150"},{"id":"R1940","pred":"punct","subj":"T7157","obj":"T7155"},{"id":"R1941","pred":"punct","subj":"T7158","obj":"T7155"},{"id":"R1942","pred":"punct","subj":"T7159","obj":"T7155"},{"id":"R1944","pred":"punct","subj":"T7160","obj":"T7139"},{"id":"R1945","pred":"prep","subj":"T7162","obj":"T7163"},{"id":"R1947","pred":"det","subj":"T7164","obj":"T7165"},{"id":"R1948","pred":"pobj","subj":"T7165","obj":"T7162"},{"id":"R1949","pred":"nummod","subj":"T7166","obj":"T7165"},{"id":"R1951","pred":"compound","subj":"T7167","obj":"T7165"},{"id":"R1952","pred":"compound","subj":"T7168","obj":"T7165"},{"id":"R1953","pred":"acl","subj":"T7169","obj":"T7165"},{"id":"R1955","pred":"punct","subj":"T7170","obj":"T7163"},{"id":"R1956","pred":"nummod","subj":"T7171","obj":"T7172"},{"id":"R1957","pred":"nsubj","subj":"T7172","obj":"T7163"},{"id":"R1958","pred":"attr","subj":"T7173","obj":"T7163"},{"id":"R1959","pred":"punct","subj":"T7174","obj":"T7173"},{"id":"R1960","pred":"punct","subj":"T7175","obj":"T7173"},{"id":"R1961","pred":"punct","subj":"T7176","obj":"T7173"},{"id":"R1962","pred":"punct","subj":"T7177","obj":"T7163"},{"id":"R1964","pred":"det","subj":"T7179","obj":"T7180"},{"id":"R1965","pred":"nsubj","subj":"T7180","obj":"T7185"},{"id":"R1966","pred":"npadvmod","subj":"T7181","obj":"T7182"},{"id":"R1968","pred":"amod","subj":"T7182","obj":"T7180"},{"id":"R1969","pred":"punct","subj":"T7183","obj":"T7182"},{"id":"R1970","pred":"compound","subj":"T7184","obj":"T7180"},{"id":"R1972","pred":"amod","subj":"T7186","obj":"T7187"},{"id":"R1973","pred":"dobj","subj":"T7187","obj":"T7185"},{"id":"R1974","pred":"punct","subj":"T7188","obj":"T7187"},{"id":"R1975","pred":"conj","subj":"T7189","obj":"T7187"},{"id":"R1976","pred":"punct","subj":"T7190","obj":"T7189"},{"id":"R1977","pred":"cc","subj":"T7191","obj":"T7189"},{"id":"R1978","pred":"conj","subj":"T7192","obj":"T7189"},{"id":"R1979","pred":"punct","subj":"T7193","obj":"T7194"},{"id":"R1980","pred":"parataxis","subj":"T7194","obj":"T7192"},{"id":"R1981","pred":"neg","subj":"T7195","obj":"T7194"},{"id":"R1982","pred":"punct","subj":"T7196","obj":"T7194"},{"id":"R1983","pred":"punct","subj":"T7197","obj":"T7185"},{"id":"R1984","pred":"advcl","subj":"T7198","obj":"T7185"},{"id":"R1985","pred":"mark","subj":"T7199","obj":"T7200"},{"id":"R1986","pred":"ccomp","subj":"T7200","obj":"T7198"},{"id":"R1987","pred":"nsubj","subj":"T7201","obj":"T7200"},{"id":"R1988","pred":"acomp","subj":"T7202","obj":"T7200"},{"id":"R1989","pred":"prep","subj":"T7203","obj":"T7200"},{"id":"R1990","pred":"compound","subj":"T7204","obj":"T7205"},{"id":"R1991","pred":"pobj","subj":"T7205","obj":"T7203"},{"id":"R1992","pred":"punct","subj":"T7206","obj":"T7185"}],"text":"We also generated ES cells from blastocysts obtained by intercrosses of ESG1+/- males and ESG1-/- females. Of the eight ES cell lines established, two clones were ESG1-/-. These ESG1-null ES cells demonstrated normal morphology, proliferation, and differentiation (not shown), confirming that ESG1 is dispensable in ES cells."}