PMC:13912 / 126-1140 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/13912","sourcedb":"PMC","sourceid":"13912","source_url":"http://www.ncbi.nlm.nih.gov/pmc/13912","text":"Using semiquantitative reverse transcription-polymerase chain \t\t\t reaction assays, we investigated the expression of variant messenger RNAs \t\t\t relative to wild-type estrogen receptor (ER)-α messenger RNA in normal \t\t\t breast tissues and their adjacent matched breast tumor tissues. Higher ER \t\t\t variant truncated after sequences encoding exon 2 of the wild-type ER-α \t\t\t (ERC4) messenger RNA and a lower exon 3 deleted ER-α variant (ERD3) \t\t\t messenger RNA relative expression in the tumor compartment were observed in the \t\t\t ER-positive/PR-positive and the ER-positive subsets, respectively. A \t\t\t significantly higher relative expression of exon 5 deleted ER-α varient \t\t\t (ERD5) messenger RNA was observed in tumor components overall. These data \t\t\t demonstrate that changes in the relative expression of ER-α variant \t\t\t messenger RNAs occur between adjacent normal and neoplastic breast tissues. We \t\t\t suggest that these changes might be involved in the mechanisms that underlie \t\t\t breast tumorigenesis.\n","tracks":[]}