PMC:13912 / 1150-2526 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/13912","sourcedb":"PMC","sourceid":"13912","source_url":"http://www.ncbi.nlm.nih.gov/pmc/13912","text":"Introduction:\nEstrogen receptor (ER)-α and ER-β are believed to \t\t\t\tmediate the action of estradiol in target tissues. Several ER-α and \t\t\t\tER-β variant messenger RNAs have been identified in both normal and \t\t\t\tneoplastic human tissues. Most of these variants contain a deletion of one or \t\t\t\tmore exons of the wild-type (WT) ER messenger RNAs. The putative proteins that \t\t\t\tare encoded by these variant messenger RNAs would therefore be missing some \t\t\t\tfunctional domains of the WT receptors, and might interfere with WT-ER \t\t\t\tsignaling pathways. The detection of ER-α variants in both normal and \t\t\t\tneoplastic human breast tissues raised the question of their possible role in \t\t\t\tbreast tumorigenesis.\nWe have previously reported an increased relative expression of \t\t\t\texon 5 deleted ER-α variant (ERD5) messenger RNA and of another ER-α \t\t\t\tvariant truncated of all sequences following the exon 2 of the WT ER-α \t\t\t\t(ERC4) messenger RNA in breast tumor samples versus independent normal breast \t\t\t\ttissues. In contrast, a decreased relative expression of exon 3 deleted \t\t\t\tER-α variant (ERD3) messenger RNA in tumor tissues and cancer cell lines \t\t\t\tversus independent normal reduction mammoplasty samples has recently been \t\t\t\treported. These data were obtained in tissues from different individuals and \t\t\t\tpossible interindividual differences cannot be excluded.","divisions":[{"label":"Title","span":{"begin":0,"end":13}}],"tracks":[]}