PMC:13902 / 24888-26071 JSONTXT

{"project":"Colil","denotations":[{"id":"T63","span":{"begin":372,"end":374},"obj":"10713680"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/"}],"text":"In the 6-week study set, eight out of 36 (22%) of the glands sampled showed histologic evidence of hyperplasia. In addition, one out of 36 glands sampled had a lesion with the appearance of a ductal carcinoma in situ (focal necrosis, marked atypia and abundant mitoses, placing it in the category of 'mammary intraepithelial neoplasia' by the Annapolis naming convention [22]), and an additional one had an invasive carcinoma. Both the in situ and the invasive carcinomas were in the control group. However, both samples also had histologically normal ducts on the same slide, which were scored for the analysis. There was no difference in staining between the ducts that were proximal to the tumor and those that were more distal, and neither were there any differences in staining observed between histologically normal and hyperplastic ducts in any of the samples analyzed (data not shown). Since the focus of the present study was on TGF-β expression changes in the preneoplastic gland, staining of the tumors was not scored for the analysis, but in the two cases present, the staining did not differ significantly from that of the surrounding normal-appearing ducts (not shown)."}