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undefined method 'each' for nil

PMC:138691 / 3111-7457 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1740 107-120 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1741 170-183 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1742 211-214 CHEBI_SO_EXT:DNA denotes DNA
T1743 244-251 SO_EXT:sequence_alteration_process denotes mutated
T1744 256-261 SO_EXT:0000704 denotes genes
T1745 267-274 SO_EXT:sequence_coding_function denotes encodes
T1746 313-320 CHEBI_PR_EXT:protein denotes protein
T1747 347-363 SO_EXT:0000061 denotes restriction site
T1748 368-374 PR_EXT:P03882 denotes I-SceI
T1749 378-383 NCBITaxon_EXT:yeast denotes yeast
T1750 384-390 SO_EXT:0000188 denotes intron
T1751 391-398 SO_EXT:sequence_coding_function denotes encoded
T1752 399-411 GO_EXT:0004519 denotes endonuclease
T1753 423-427 CHEBI_SO_EXT:base denotes base
T1754 423-432 SO_EXT:0000028 denotes base pair
T1755 433-449 SO_EXT:0000409 denotes recognition site
T1756 461-473 GO:0009294 denotes transfection
T1757 480-486 PR_EXT:P03882 denotes I-SceI
T1758 487-497 GO:0010467 denotes expression
T1759 498-504 SO_EXT:0000440 denotes vector
T1760 553-560 SO_EXT:sequence_alteration_process denotes mutated
T1761 561-565 SO_EXT:sequence_copy_entity denotes copy
T1762 586-589 CHEBI_SO_EXT:DNA denotes DNA
T1763 615-624 GO:0042148 denotes invade(s)
T1764 640-648 SO_EXT:biological_sequence denotes sequence
T1765 663-669 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1766 674-678 SO_EXT:sequence_copy_entity denotes copy
T1767 693-702 _FRAGMENT denotes repair of
T1768 707-710 GO:0006302 denotes DSB
T1769 735-739 SO_EXT:0000704 denotes gene
T1770 735-750 GO:0035822 denotes gene conversion
T1771 787-796 SO_EXT:engineered_biological_sequence denotes construct
T1772 828-834 GO:0006281 denotes repair
T1773 882-886 SO_EXT:sequence_copy_entity denotes copy
T1774 949-953 CL_GO_EXT:cell denotes cell
T1775 990-1000 GO:0010467 denotes expression
T1776 1501-1514 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1777 1545-1550 CL_GO_EXT:cell denotes cells
T1778 1566-1571 PR_EXT:000004804 denotes BRCA2
T1779 1572-1579 CHEBI_PR_EXT:protein denotes protein
T1780 1614-1620 GO:0006281 denotes repair
T1781 1625-1631 PR_EXT:P03882 denotes I-SceI
T1782 1663-1676 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1783 1678-1688 GO:0010467 denotes Expression
T1784 1692-1698 PR_EXT:P03882 denotes I-SceI
T1785 1725-1730 CL_GO_EXT:cell denotes cells
T1786 1760-1773 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1787 1781-1786 NCBITaxon:9606 denotes human
T1788 1787-1797 UBERON:0001264 denotes pancreatic
T1789 1804-1808 CL_GO_EXT:cell denotes cell
T1790 1831-1836 CL_GO_EXT:cell denotes cells
T1791 1845-1853 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T1792 1857-1862 PR_EXT:000004804 denotes BRCA2
T1793 1882-1887 SO_EXT:sequence_coding_function denotes codes
T1794 1894-1901 CHEBI_PR_EXT:protein denotes protein
T1795 1902-1911 SO_EXT:sequence_truncation_process denotes truncated
T1796 1915-1925 CHEBI_SO_EXT:amino_acid denotes amino acid
T1797 1992-1998 PR_EXT:P03882 denotes I-SceI
T1798 2007-2020 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1799 2082-2087 PR_EXT:000004804 denotes BRCA2
T1800 2087-2088 SO_EXT:normal_or_wild_type_or_present denotes +
T1801 2090-2095 NCBITaxon:9606 denotes human
T1802 2102-2106 CL_GO_EXT:cell denotes cell
T1803 2179-2190 SO_EXT:0000704 denotes genetically
T1804 2204-2209 CL_GO_EXT:cell denotes cells
T1805 2226-2231 PR_EXT:000004804 denotes BRCA2
T1806 2348-2363 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T1807 2348-2370 GO:0000725 denotes recombinational repair
T1808 2410-2419 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T1809 2427-2432 PR_EXT:000004804 denotes BRCA2
T1810 2559-2574 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T1811 2559-2581 GO:0000725 denotes recombinational repair
T1812 2604-2609 CL_GO_EXT:cell denotes cells
T1813 2653-2658 PR_EXT:000004804 denotes BRCA2
T1814 2691-2704 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1815 2710-2715 NCBITaxon:10088 denotes mouse
T1816 2716-2723 CL:0002322 denotes ES cell
T1817 2719-2723 CL_GO_EXT:cell denotes cell
T1818 2734-2743 GO:0010467 denotes expresses
T1819 2749-2758 SO_EXT:sequence_truncation_process denotes truncated
T1820 2759-2764 PR_EXT:000004804 denotes BRCA2
T1821 2765-2772 CHEBI_PR_EXT:protein denotes protein
T1822 2821-2834 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1823 2860-2865 CL_GO_EXT:cell denotes cells
T1824 2866-2876 GO:0010467 denotes expressing
T1825 2889-2894 PR_EXT:000004804 denotes BRCA2
T1826 3070-3077 GO:0010467 denotes express
T1827 3090-3095 PR_EXT:000004804 denotes BRCA2
T1828 3096-3103 CHEBI_PR_EXT:protein denotes protein
T1829 3184-3194 GO:0010467 denotes expressing
T1830 3207-3212 PR_EXT:000004804 denotes BRCA2
T1831 3234-3246 SO_EXT:sequence_recombinant_entity denotes recombinants
T1832 3261-3271 GO:0010467 denotes expressing
T1833 3277-3286 SO_EXT:sequence_truncation_process denotes truncated
T1834 3287-3292 PR_EXT:000004804 denotes BRCA2
T1835 3492-3497 CL_GO_EXT:cell denotes cells
T1836 3517-3525 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1837 3556-3571 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T1838 3556-3578 GO:0000725 denotes recombinational repair
T1839 3614-3619 NCBITaxon:9606 denotes human
T1840 3620-3624 CL_GO_EXT:cell denotes cell
T1841 3648-3653 PR_EXT:000004804 denotes BRCA2
T1842 3726-3739 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1843 3756-3761 PR_EXT:000004804 denotes BRCA2
T1844 3904-3909 NCBITaxon:9606 denotes human
T1845 3980-3985 PR_EXT:000004804 denotes Brca2
T1846 3994-3999 CL_GO_EXT:cell denotes cells
T1847 4004-4009 PR_EXT:000004804 denotes Brca2
T1848 4009-4010 SO_EXT:normal_or_wild_type_or_present denotes +
T1849 4011-4012 SO_EXT:normal_or_wild_type_or_present denotes +
T1850 4013-4021 CL:0002322 denotes ES cells
T1851 4016-4021 CL_GO_EXT:cell denotes cells
T1852 4069-4074 PR_EXT:000004804 denotes Brca2
T1853 4093-4097 SO_EXT:sequence_nullness denotes null
T1854 4098-4104 SO_EXT:0001023 denotes allele
T1855 4171-4176 PR_EXT:000004804 denotes BRCA2
T1856 4189-4202 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1857 4255-4260 PR_EXT:000004804 denotes BRCA2
T1858 4299-4314 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T1859 4299-4321 GO:0000725 denotes recombinational repair
T1860 4330-4335 NCBITaxon:9606 denotes human
T1861 4340-4345 NCBITaxon:10088 denotes mouse
R1259 T1768 T1767 _lexicallyChainedTo DSB,repair of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T941 256-261 SO:0000704 denotes genes
T942 347-363 SO:0000061 denotes restriction site
T943 368-374 PR:P03882 denotes I-SceI
T944 384-390 SO:0000188 denotes intron
T945 423-432 SO:0000028 denotes base pair
T946 433-449 SO:0000409 denotes recognition site
T947 461-473 GO:0009294 denotes transfection
T948 480-486 PR:P03882 denotes I-SceI
T949 487-497 GO:0010467 denotes expression
T950 498-504 SO:0000440 denotes vector
T951 615-624 GO:0042148 denotes invade(s)
T952 693-702 _FRAGMENT denotes repair of
T953 707-710 GO:0006302 denotes DSB
T954 735-739 SO:0000704 denotes gene
T955 735-750 GO:0035822 denotes gene conversion
T956 828-834 GO:0006281 denotes repair
T957 990-1000 GO:0010467 denotes expression
T958 1566-1571 PR:000004804 denotes BRCA2
T959 1614-1620 GO:0006281 denotes repair
T960 1625-1631 PR:P03882 denotes I-SceI
T961 1678-1688 GO:0010467 denotes Expression
T962 1692-1698 PR:P03882 denotes I-SceI
T963 1781-1786 NCBITaxon:9606 denotes human
T964 1787-1797 UBERON:0001264 denotes pancreatic
T965 1857-1862 PR:000004804 denotes BRCA2
T966 1992-1998 PR:P03882 denotes I-SceI
T967 2082-2087 PR:000004804 denotes BRCA2
T968 2090-2095 NCBITaxon:9606 denotes human
T969 2179-2190 SO:0000704 denotes genetically
T970 2226-2231 PR:000004804 denotes BRCA2
T971 2348-2370 GO:0000725 denotes recombinational repair
T972 2427-2432 PR:000004804 denotes BRCA2
T973 2559-2581 GO:0000725 denotes recombinational repair
T974 2653-2658 PR:000004804 denotes BRCA2
T975 2710-2715 NCBITaxon:10088 denotes mouse
T976 2716-2723 CL:0002322 denotes ES cell
T977 2734-2743 GO:0010467 denotes expresses
T978 2759-2764 PR:000004804 denotes BRCA2
T979 2866-2876 GO:0010467 denotes expressing
T980 2889-2894 PR:000004804 denotes BRCA2
T981 3070-3077 GO:0010467 denotes express
T982 3090-3095 PR:000004804 denotes BRCA2
T983 3184-3194 GO:0010467 denotes expressing
T984 3207-3212 PR:000004804 denotes BRCA2
T985 3261-3271 GO:0010467 denotes expressing
T986 3287-3292 PR:000004804 denotes BRCA2
T987 3556-3578 GO:0000725 denotes recombinational repair
T988 3614-3619 NCBITaxon:9606 denotes human
T989 3648-3653 PR:000004804 denotes BRCA2
T990 3756-3761 PR:000004804 denotes BRCA2
T991 3904-3909 NCBITaxon:9606 denotes human
T992 3980-3985 PR:000004804 denotes Brca2
T993 4004-4009 PR:000004804 denotes Brca2
T994 4013-4021 CL:0002322 denotes ES cells
T995 4069-4074 PR:000004804 denotes Brca2
T996 4098-4104 SO:0001023 denotes allele
T997 4171-4176 PR:000004804 denotes BRCA2
T998 4255-4260 PR:000004804 denotes BRCA2
T999 4299-4321 GO:0000725 denotes recombinational repair
T1000 4330-4335 NCBITaxon:9606 denotes human
T1001 4340-4345 NCBITaxon:10088 denotes mouse
R563 T953 T952 _lexicallyChainedTo DSB,repair of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T1002 71-77 NNP denotes Pierce
T1003 89-97 VBN denotes designed
T1004 78-80 FW denotes et
T1005 81-83 FW denotes al
T1006 84-88 VBP denotes have
T1007 98-99 DT denotes a
T1008 100-103 NN denotes set
T1009 104-106 IN denotes of
T1010 107-120 NN denotes recombination
T1011 121-131 NNS denotes substrates
T1012 132-135 IN denotes for
T1013 136-145 VBG denotes measuring
T1014 146-149 DT denotes the
T1015 150-155 NN denotes level
T1016 156-158 IN denotes of
T1017 159-169 JJ denotes homologous
T1018 170-183 NN denotes recombination
T1019 184-186 FW denotes in
T1020 187-191 FW denotes vivo
T1021 192-193 -LRB- denotes (
T1022 193-197 NN denotes Fig.
T1023 198-199 CD denotes 1
T1024 199-200 -RRB- denotes )
T1025 201-202 -LRB- denotes [
T1026 202-204 CD denotes 25
T1027 204-205 -RRB- denotes ]
T1028 205-206 . denotes .
T1029 206-450 sentence denotes The DNA substrate contains a pair of mutated GFP genes (GFP encodes the easily detected green fluorescent protein), one of which contains a restriction site for I-SceI, a yeast intron encoded endonuclease with an 18 base pair recognition site.
T1030 207-210 DT denotes The
T1031 215-224 NN denotes substrate
T1032 211-214 NN denotes DNA
T1033 225-233 VBZ denotes contains
T1034 234-235 DT denotes a
T1035 236-240 NN denotes pair
T1036 241-243 IN denotes of
T1037 244-251 VBN denotes mutated
T1038 256-261 NNS denotes genes
T1039 252-255 NN denotes GFP
T1040 262-263 -LRB- denotes (
T1041 267-274 VBZ denotes encodes
T1042 263-266 NN denotes GFP
T1043 275-278 DT denotes the
T1044 313-320 NN denotes protein
T1045 279-285 RB denotes easily
T1046 286-294 VBN denotes detected
T1047 295-300 JJ denotes green
T1048 301-312 JJ denotes fluorescent
T1049 320-321 -RRB- denotes )
T1050 321-323 , denotes ,
T1051 323-326 CD denotes one
T1052 336-344 VBZ denotes contains
T1053 327-329 IN denotes of
T1054 330-335 WDT denotes which
T1055 345-346 DT denotes a
T1056 359-363 NN denotes site
T1057 347-358 NN denotes restriction
T1058 364-367 IN denotes for
T1059 368-369 NN denotes I
T1060 370-374 NN denotes SceI
T1061 369-370 HYPH denotes -
T1062 374-376 , denotes ,
T1063 376-377 DT denotes a
T1064 399-411 NN denotes endonuclease
T1065 378-383 NN denotes yeast
T1066 384-390 NN denotes intron
T1067 391-398 VBN denotes encoded
T1068 412-416 IN denotes with
T1069 417-419 DT denotes an
T1070 445-449 NN denotes site
T1071 420-422 CD denotes 18
T1072 428-432 NN denotes pair
T1073 423-427 NN denotes base
T1074 433-444 NN denotes recognition
T1075 449-450 . denotes .
T1076 450-573 sentence denotes Transient transfection of an I-SceI expression vector results in the production of a DSB in the first mutated copy of GFP.
T1077 451-460 JJ denotes Transient
T1078 461-473 NN denotes transfection
T1079 505-512 VBZ denotes results
T1080 474-476 IN denotes of
T1081 477-479 DT denotes an
T1082 498-504 NN denotes vector
T1083 480-481 NN denotes I
T1084 482-486 NN denotes SceI
T1085 481-482 HYPH denotes -
T1086 487-497 NN denotes expression
T1087 513-515 IN denotes in
T1088 516-519 DT denotes the
T1089 520-530 NN denotes production
T1090 531-533 IN denotes of
T1091 534-535 DT denotes a
T1092 536-539 NN denotes DSB
T1093 540-542 IN denotes in
T1094 543-546 DT denotes the
T1095 561-565 NN denotes copy
T1096 547-552 JJ denotes first
T1097 553-560 VBN denotes mutated
T1098 566-568 IN denotes of
T1099 569-572 NN denotes GFP
T1100 572-573 . denotes .
T1101 573-757 sentence denotes One or both DNA ends formed by the break invade(s) the homologous sequence in the second mutant GFP copy, resulting in repair of the DSB via a homology-mediated gene conversion event.
T1102 574-577 CD denotes One
T1103 615-621 VB denotes invade
T1104 578-580 CC denotes or
T1105 581-585 CC denotes both
T1106 590-594 NNS denotes ends
T1107 586-589 NN denotes DNA
T1108 595-601 VBN denotes formed
T1109 602-604 IN denotes by
T1110 605-608 DT denotes the
T1111 609-614 NN denotes break
T1112 621-622 -LRB- denotes (
T1113 622-623 VBZ denotes s
T1114 623-624 -RRB- denotes )
T1115 625-628 DT denotes the
T1116 640-648 NN denotes sequence
T1117 629-639 JJ denotes homologous
T1118 649-651 IN denotes in
T1119 652-655 DT denotes the
T1120 674-678 NN denotes copy
T1121 656-662 JJ denotes second
T1122 663-669 JJ denotes mutant
T1123 670-673 NN denotes GFP
T1124 678-680 , denotes ,
T1125 680-689 VBG denotes resulting
T1126 690-692 IN denotes in
T1127 693-699 NN denotes repair
T1128 700-702 IN denotes of
T1129 703-706 DT denotes the
T1130 707-710 NN denotes DSB
T1131 711-714 IN denotes via
T1132 715-716 DT denotes a
T1133 751-756 NN denotes event
T1134 717-725 NN denotes homology
T1135 726-734 VBN denotes mediated
T1136 725-726 HYPH denotes -
T1137 735-739 NN denotes gene
T1138 740-750 NN denotes conversion
T1139 756-757 . denotes .
T1140 757-894 sentence denotes The configuration of the GFP construct is such that homology-mediated repair often results in the formation of a functional copy of GFP.
T1141 758-761 DT denotes The
T1142 762-775 NN denotes configuration
T1143 797-799 VBZ denotes is
T1144 776-778 IN denotes of
T1145 779-782 DT denotes the
T1146 787-796 NN denotes construct
T1147 783-786 NN denotes GFP
T1148 800-804 JJ denotes such
T1149 805-809 IN denotes that
T1150 841-848 VBZ denotes results
T1151 810-818 NN denotes homology
T1152 819-827 VBN denotes mediated
T1153 818-819 HYPH denotes -
T1154 828-834 NN denotes repair
T1155 835-840 RB denotes often
T1156 849-851 IN denotes in
T1157 852-855 DT denotes the
T1158 856-865 NN denotes formation
T1159 866-868 IN denotes of
T1160 869-870 DT denotes a
T1161 882-886 NN denotes copy
T1162 871-881 JJ denotes functional
T1163 887-889 IN denotes of
T1164 890-893 NN denotes GFP
T1165 893-894 . denotes .
T1166 894-1008 sentence denotes Such events can be detected by fluorescence-activated cell sorting analysis by virtue of their expression of GFP.
T1167 895-899 JJ denotes Such
T1168 900-906 NNS denotes events
T1169 914-922 VBN denotes detected
T1170 907-910 MD denotes can
T1171 911-913 VB denotes be
T1172 923-925 IN denotes by
T1173 926-938 NN denotes fluorescence
T1174 939-948 VBN denotes activated
T1175 938-939 HYPH denotes -
T1176 954-961 NN denotes sorting
T1177 949-953 NN denotes cell
T1178 962-970 NN denotes analysis
T1179 971-973 IN denotes by
T1180 974-980 NN denotes virtue
T1181 981-983 IN denotes of
T1182 984-989 PRP$ denotes their
T1183 990-1000 NN denotes expression
T1184 1001-1003 IN denotes of
T1185 1004-1007 NN denotes GFP
T1186 1007-1008 . denotes .
T1187 1008-1677 sentence denotes Figure 1 Recombination substrates used for assaying homology-directed repair. Cutting at the I-SceI site within the mutant GFP (SceGFP) results in a double-strand break that can be repaired through homologous gene conversion using a 3'-truncated copy of GFP as sequence donor. The mechanism results in the formation of a functional copy of the GFP gene. The model shown assumes gene conversion occurs via the synthesis-dependent annealing mechanism. Moynahan et al [24] have used such a GFP recombination substrate to demonstrate that cells with defective BRCA2 protein are deficient in their ability to repair the I-SceI-induced DSB through homologous recombination.
T1188 1460-1468 NNP denotes Moynahan
T1189 1485-1489 VBN denotes used
T1190 1469-1471 FW denotes et
T1191 1472-1474 FW denotes al
T1192 1475-1476 -LRB- denotes [
T1193 1476-1478 CD denotes 24
T1194 1478-1479 -RRB- denotes ]
T1195 1480-1484 VBP denotes have
T1196 1490-1494 PDT denotes such
T1197 1515-1524 NN denotes substrate
T1198 1495-1496 DT denotes a
T1199 1497-1500 NN denotes GFP
T1200 1501-1514 NN denotes recombination
T1201 1525-1527 TO denotes to
T1202 1528-1539 VB denotes demonstrate
T1203 1540-1544 IN denotes that
T1204 1580-1583 VBP denotes are
T1205 1545-1550 NNS denotes cells
T1206 1551-1555 IN denotes with
T1207 1556-1565 JJ denotes defective
T1208 1572-1579 NN denotes protein
T1209 1566-1571 NN denotes BRCA2
T1210 1584-1593 JJ denotes deficient
T1211 1594-1596 IN denotes in
T1212 1597-1602 PRP$ denotes their
T1213 1603-1610 NN denotes ability
T1214 1611-1613 TO denotes to
T1215 1614-1620 VB denotes repair
T1216 1621-1624 DT denotes the
T1217 1640-1643 NN denotes DSB
T1218 1625-1626 NN denotes I
T1219 1627-1631 NN denotes SceI
T1220 1626-1627 HYPH denotes -
T1221 1632-1639 VBN denotes induced
T1222 1631-1632 HYPH denotes -
T1223 1644-1651 IN denotes through
T1224 1652-1662 JJ denotes homologous
T1225 1663-1676 NN denotes recombination
T1226 1676-1677 . denotes .
T1227 1677-1822 sentence denotes Expression of I-SceI resulted in 1 out of 1400 cells producing GFP via homologous recombination in the human pancreatic tumor cell line CAPAN-1.
T1228 1678-1688 NN denotes Expression
T1229 1699-1707 VBD denotes resulted
T1230 1689-1691 IN denotes of
T1231 1692-1693 NN denotes I
T1232 1694-1698 NN denotes SceI
T1233 1693-1694 HYPH denotes -
T1234 1708-1710 IN denotes in
T1235 1711-1712 CD denotes 1
T1236 1720-1724 CD denotes 1400
T1237 1713-1716 IN denotes out
T1238 1717-1719 IN denotes of
T1239 1725-1730 NNS denotes cells
T1240 1731-1740 VBG denotes producing
T1241 1741-1744 NN denotes GFP
T1242 1745-1748 IN denotes via
T1243 1749-1759 JJ denotes homologous
T1244 1760-1773 NN denotes recombination
T1245 1774-1776 IN denotes in
T1246 1777-1780 DT denotes the
T1247 1809-1813 NN denotes line
T1248 1781-1786 JJ denotes human
T1249 1804-1808 NN denotes cell
T1250 1787-1797 JJ denotes pancreatic
T1251 1798-1803 NN denotes tumor
T1252 1814-1819 NN denotes CAPAN
T1253 1819-1820 HYPH denotes -
T1254 1820-1821 CD denotes 1
T1255 1821-1822 . denotes .
T1256 1822-1952 sentence denotes CAPAN-1 cells carry a deletion of BRCA2 on one homolog and codes for a protein truncated at amino acid 1981 on the other homolog.
T1257 1823-1828 NN denotes CAPAN
T1258 1831-1836 NNS denotes cells
T1259 1828-1829 HYPH denotes -
T1260 1829-1830 CD denotes 1
T1261 1837-1842 VBP denotes carry
T1262 1843-1844 DT denotes a
T1263 1845-1853 NN denotes deletion
T1264 1854-1856 IN denotes of
T1265 1857-1862 NN denotes BRCA2
T1266 1863-1865 IN denotes on
T1267 1866-1869 CD denotes one
T1268 1870-1877 NN denotes homolog
T1269 1878-1881 CC denotes and
T1270 1882-1887 NNS denotes codes
T1271 1888-1891 IN denotes for
T1272 1892-1893 DT denotes a
T1273 1894-1901 NN denotes protein
T1274 1902-1911 VBN denotes truncated
T1275 1912-1914 IN denotes at
T1276 1915-1920 JJ denotes amino
T1277 1921-1925 NN denotes acid
T1278 1926-1930 CD denotes 1981
T1279 1931-1933 IN denotes on
T1280 1934-1937 DT denotes the
T1281 1944-1951 NN denotes homolog
T1282 1938-1943 JJ denotes other
T1283 1951-1952 . denotes .
T1284 1952-2113 sentence denotes The authors indicate that the level of I-SceI-induced recombination in CAPAN-1 is over 100-fold less than that seen using other (BRCA2+) human tumor cell lines.
T1285 1953-1956 DT denotes The
T1286 1957-1964 NNS denotes authors
T1287 1965-1973 VBP denotes indicate
T1288 1974-1978 IN denotes that
T1289 2032-2034 VBZ denotes is
T1290 1979-1982 DT denotes the
T1291 1983-1988 NN denotes level
T1292 1989-1991 IN denotes of
T1293 1992-1993 NN denotes I
T1294 1994-1998 NN denotes SceI
T1295 1993-1994 HYPH denotes -
T1296 1999-2006 VBN denotes induced
T1297 1998-1999 HYPH denotes -
T1298 2007-2020 NN denotes recombination
T1299 2021-2023 IN denotes in
T1300 2024-2029 NN denotes CAPAN
T1301 2029-2030 HYPH denotes -
T1302 2030-2031 CD denotes 1
T1303 2035-2039 IN denotes over
T1304 2040-2048 RB denotes 100-fold
T1305 2049-2053 JJR denotes less
T1306 2054-2058 IN denotes than
T1307 2059-2063 DT denotes that
T1308 2064-2068 VBN denotes seen
T1309 2069-2074 VBG denotes using
T1310 2075-2080 JJ denotes other
T1311 2082-2088 JJ denotes BRCA2+
T1312 2081-2082 -LRB- denotes (
T1313 2107-2112 NNS denotes lines
T1314 2088-2089 -RRB- denotes )
T1315 2090-2095 JJ denotes human
T1316 2096-2101 NN denotes tumor
T1317 2102-2106 NN denotes cell
T1318 2112-2113 . denotes .
T1319 2113-2290 sentence denotes The different lines examined, however, are very likely to differ genetically from CAPAN-1 cells not only at the BRCA2 locus, but also at a very large number of additional loci.
T1320 2114-2117 DT denotes The
T1321 2128-2133 NNS denotes lines
T1322 2118-2127 JJ denotes different
T1323 2153-2156 VBP denotes are
T1324 2134-2142 VBN denotes examined
T1325 2142-2144 , denotes ,
T1326 2144-2151 RB denotes however
T1327 2151-2153 , denotes ,
T1328 2157-2161 RB denotes very
T1329 2162-2168 JJ denotes likely
T1330 2169-2171 TO denotes to
T1331 2172-2178 VB denotes differ
T1332 2179-2190 RB denotes genetically
T1333 2191-2195 IN denotes from
T1334 2196-2201 NN denotes CAPAN
T1335 2204-2209 NNS denotes cells
T1336 2201-2202 HYPH denotes -
T1337 2202-2203 CD denotes 1
T1338 2210-2213 RB denotes not
T1339 2219-2221 IN denotes at
T1340 2214-2218 RB denotes only
T1341 2222-2225 DT denotes the
T1342 2232-2237 NN denotes locus
T1343 2226-2231 NN denotes BRCA2
T1344 2237-2239 , denotes ,
T1345 2239-2242 CC denotes but
T1346 2243-2247 RB denotes also
T1347 2248-2250 IN denotes at
T1348 2251-2252 DT denotes a
T1349 2264-2270 NN denotes number
T1350 2253-2257 RB denotes very
T1351 2258-2263 JJ denotes large
T1352 2271-2273 IN denotes of
T1353 2274-2284 JJ denotes additional
T1354 2285-2289 NNS denotes loci
T1355 2289-2290 . denotes .
T1356 2290-2438 sentence denotes This raises the possibility that some or even all of the recombinational repair defect seen in CAPAN-1 could be due to mutations at non-BRCA2 loci.
T1357 2291-2295 DT denotes This
T1358 2296-2302 VBZ denotes raises
T1359 2303-2306 DT denotes the
T1360 2307-2318 NN denotes possibility
T1361 2319-2323 IN denotes that
T1362 2400-2402 VB denotes be
T1363 2324-2328 DT denotes some
T1364 2329-2331 CC denotes or
T1365 2332-2336 RB denotes even
T1366 2337-2340 DT denotes all
T1367 2341-2343 IN denotes of
T1368 2344-2347 DT denotes the
T1369 2371-2377 NN denotes defect
T1370 2348-2363 JJ denotes recombinational
T1371 2364-2370 NN denotes repair
T1372 2378-2382 VBN denotes seen
T1373 2383-2385 IN denotes in
T1374 2386-2391 NN denotes CAPAN
T1375 2391-2392 HYPH denotes -
T1376 2392-2393 CD denotes 1
T1377 2394-2399 MD denotes could
T1378 2403-2406 IN denotes due
T1379 2407-2409 IN denotes to
T1380 2410-2419 NNS denotes mutations
T1381 2420-2422 IN denotes at
T1382 2423-2432 JJ denotes non-BRCA2
T1383 2433-2437 NNS denotes loci
T1384 2437-2438 . denotes .
T1385 2438-2659 sentence denotes While Moynahan et al were careful to point out this problem, two sets of results argue against the possibility that the recombinational repair deficiency of CAPAN-1 cells is completely independent of its defect in BRCA2.
T1386 2439-2444 IN denotes While
T1387 2460-2464 VBD denotes were
T1388 2445-2453 NNP denotes Moynahan
T1389 2454-2456 FW denotes et
T1390 2457-2459 FW denotes al
T1391 2520-2525 VBP denotes argue
T1392 2465-2472 JJ denotes careful
T1393 2473-2475 TO denotes to
T1394 2476-2481 VB denotes point
T1395 2482-2485 RP denotes out
T1396 2486-2490 DT denotes this
T1397 2491-2498 NN denotes problem
T1398 2498-2500 , denotes ,
T1399 2500-2503 CD denotes two
T1400 2504-2508 NNS denotes sets
T1401 2509-2511 IN denotes of
T1402 2512-2519 NNS denotes results
T1403 2526-2533 IN denotes against
T1404 2534-2537 DT denotes the
T1405 2538-2549 NN denotes possibility
T1406 2550-2554 IN denotes that
T1407 2610-2612 VBZ denotes is
T1408 2555-2558 DT denotes the
T1409 2582-2592 NN denotes deficiency
T1410 2559-2574 JJ denotes recombinational
T1411 2575-2581 NN denotes repair
T1412 2593-2595 IN denotes of
T1413 2596-2601 NN denotes CAPAN
T1414 2604-2609 NNS denotes cells
T1415 2601-2602 HYPH denotes -
T1416 2602-2603 CD denotes 1
T1417 2613-2623 RB denotes completely
T1418 2624-2635 JJ denotes independent
T1419 2636-2638 IN denotes of
T1420 2639-2642 PRP$ denotes its
T1421 2643-2649 NN denotes defect
T1422 2650-2652 IN denotes in
T1423 2653-2658 NN denotes BRCA2
T1424 2658-2659 . denotes .
T1425 2659-2786 sentence denotes First, in the same study [24], recombination in a mouse ES cell line that expresses only truncated BRCA2 protein was measured.
T1426 2660-2665 RB denotes First
T1427 2777-2785 VBN denotes measured
T1428 2665-2667 , denotes ,
T1429 2667-2669 IN denotes in
T1430 2670-2673 DT denotes the
T1431 2679-2684 NN denotes study
T1432 2674-2678 JJ denotes same
T1433 2685-2686 -LRB- denotes [
T1434 2686-2688 CD denotes 24
T1435 2688-2689 -RRB- denotes ]
T1436 2689-2691 , denotes ,
T1437 2691-2704 NN denotes recombination
T1438 2705-2707 IN denotes in
T1439 2708-2709 DT denotes a
T1440 2724-2728 NN denotes line
T1441 2710-2715 NN denotes mouse
T1442 2716-2718 NN denotes ES
T1443 2719-2723 NN denotes cell
T1444 2729-2733 WDT denotes that
T1445 2734-2743 VBZ denotes expresses
T1446 2744-2748 RB denotes only
T1447 2765-2772 NN denotes protein
T1448 2749-2758 VBN denotes truncated
T1449 2759-2764 NN denotes BRCA2
T1450 2773-2776 VBD denotes was
T1451 2785-2786 . denotes .
T1452 2786-2947 sentence denotes This line was found to have lower recombination efficiency than isogenic cells expressing full-length BRCA2 (the defect observed was about fivefold to sixfold).
T1453 2787-2791 DT denotes This
T1454 2792-2796 NN denotes line
T1455 2801-2806 VBN denotes found
T1456 2797-2800 VBD denotes was
T1457 2807-2809 TO denotes to
T1458 2810-2814 VB denotes have
T1459 2815-2820 JJR denotes lower
T1460 2835-2845 NN denotes efficiency
T1461 2821-2834 NN denotes recombination
T1462 2846-2850 IN denotes than
T1463 2851-2859 JJ denotes isogenic
T1464 2860-2865 NNS denotes cells
T1465 2866-2876 VBG denotes expressing
T1466 2877-2881 JJ denotes full
T1467 2882-2888 NN denotes length
T1468 2881-2882 HYPH denotes -
T1469 2889-2894 NN denotes BRCA2
T1470 2895-2896 -LRB- denotes (
T1471 2916-2919 VBD denotes was
T1472 2896-2899 DT denotes the
T1473 2900-2906 NN denotes defect
T1474 2907-2915 VBN denotes observed
T1475 2920-2925 RB denotes about
T1476 2938-2945 RB denotes sixfold
T1477 2926-2934 RB denotes fivefold
T1478 2935-2937 IN denotes to
T1479 2945-2946 -RRB- denotes )
T1480 2946-2947 . denotes .
T1481 2947-3146 sentence denotes Second, in an independent study, Powell was able to compare derivatives of CAPAN-1 that differed only in their ability to express full-length BRCA2 protein (S. Powell, personal communication, 2001).
T1482 2948-2954 RB denotes Second
T1483 2988-2991 VBD denotes was
T1484 2954-2956 , denotes ,
T1485 2956-2958 IN denotes in
T1486 2959-2961 DT denotes an
T1487 2974-2979 NN denotes study
T1488 2962-2973 JJ denotes independent
T1489 2979-2981 , denotes ,
T1490 2981-2987 NNP denotes Powell
T1491 2992-2996 JJ denotes able
T1492 2997-2999 TO denotes to
T1493 3000-3007 VB denotes compare
T1494 3008-3019 NNS denotes derivatives
T1495 3020-3022 IN denotes of
T1496 3023-3028 NN denotes CAPAN
T1497 3028-3029 HYPH denotes -
T1498 3029-3030 CD denotes 1
T1499 3031-3035 WDT denotes that
T1500 3036-3044 VBD denotes differed
T1501 3045-3049 RB denotes only
T1502 3050-3052 IN denotes in
T1503 3053-3058 PRP$ denotes their
T1504 3059-3066 NN denotes ability
T1505 3067-3069 TO denotes to
T1506 3070-3077 VB denotes express
T1507 3078-3082 JJ denotes full
T1508 3083-3089 NN denotes length
T1509 3082-3083 HYPH denotes -
T1510 3096-3103 NN denotes protein
T1511 3090-3095 NN denotes BRCA2
T1512 3104-3105 -LRB- denotes (
T1513 3108-3114 NNP denotes Powell
T1514 3105-3107 NNP denotes S.
T1515 3114-3116 , denotes ,
T1516 3116-3124 JJ denotes personal
T1517 3125-3138 NN denotes communication
T1518 3138-3140 , denotes ,
T1519 3140-3144 CD denotes 2001
T1520 3144-3145 -RRB- denotes )
T1521 3145-3146 . denotes .
T1522 3146-3335 sentence denotes In these experiments, the derivative expressing full-length BRCA2 yielded 10-fold more recombinants than controls expressing only truncated BRCA2 (S. Powell, personal communication, 2001).
T1523 3147-3149 IN denotes In
T1524 3213-3220 VBD denotes yielded
T1525 3150-3155 DT denotes these
T1526 3156-3167 NNS denotes experiments
T1527 3167-3169 , denotes ,
T1528 3169-3172 DT denotes the
T1529 3173-3183 NN denotes derivative
T1530 3184-3194 VBG denotes expressing
T1531 3195-3199 JJ denotes full
T1532 3200-3206 NN denotes length
T1533 3199-3200 HYPH denotes -
T1534 3207-3212 NN denotes BRCA2
T1535 3221-3228 RB denotes 10-fold
T1536 3229-3233 JJR denotes more
T1537 3234-3246 NNS denotes recombinants
T1538 3247-3251 IN denotes than
T1539 3252-3260 NNS denotes controls
T1540 3261-3271 VBG denotes expressing
T1541 3272-3276 RB denotes only
T1542 3287-3292 NN denotes BRCA2
T1543 3277-3286 VBN denotes truncated
T1544 3293-3294 -LRB- denotes (
T1545 3297-3303 NNP denotes Powell
T1546 3294-3296 NNP denotes S.
T1547 3303-3305 , denotes ,
T1548 3305-3313 JJ denotes personal
T1549 3314-3327 NN denotes communication
T1550 3327-3329 , denotes ,
T1551 3329-3333 CD denotes 2001
T1552 3333-3334 -RRB- denotes )
T1553 3334-3335 . denotes .
T1554 3335-3631 sentence denotes While the experimental design of these experiments was somewhat different from that of Moyna-han et al [24], the results raise the possibility that CAPAN-1 cells have more than one mutation that lowers the efficiency of recombinational repair relative to that observed in other human cell lines.
T1555 3336-3341 IN denotes While
T1556 3387-3390 VBD denotes was
T1557 3342-3345 DT denotes the
T1558 3359-3365 NN denotes design
T1559 3346-3358 JJ denotes experimental
T1560 3366-3368 IN denotes of
T1561 3369-3374 DT denotes these
T1562 3375-3386 NNS denotes experiments
T1563 3457-3462 VBP denotes raise
T1564 3391-3399 RB denotes somewhat
T1565 3400-3409 JJ denotes different
T1566 3410-3414 IN denotes from
T1567 3415-3419 DT denotes that
T1568 3420-3422 IN denotes of
T1569 3423-3428 NNP denotes Moyna
T1570 3429-3432 NNP denotes han
T1571 3428-3429 HYPH denotes -
T1572 3433-3435 FW denotes et
T1573 3436-3438 FW denotes al
T1574 3439-3440 -LRB- denotes [
T1575 3440-3442 CD denotes 24
T1576 3442-3443 -RRB- denotes ]
T1577 3443-3445 , denotes ,
T1578 3445-3448 DT denotes the
T1579 3449-3456 NNS denotes results
T1580 3463-3466 DT denotes the
T1581 3467-3478 NN denotes possibility
T1582 3479-3483 IN denotes that
T1583 3498-3502 VBP denotes have
T1584 3484-3489 NN denotes CAPAN
T1585 3492-3497 NNS denotes cells
T1586 3489-3490 HYPH denotes -
T1587 3490-3491 CD denotes 1
T1588 3503-3507 JJR denotes more
T1589 3513-3516 CD denotes one
T1590 3508-3512 IN denotes than
T1591 3517-3525 NN denotes mutation
T1592 3526-3530 WDT denotes that
T1593 3531-3537 VBZ denotes lowers
T1594 3538-3541 DT denotes the
T1595 3542-3552 NN denotes efficiency
T1596 3553-3555 IN denotes of
T1597 3556-3571 JJ denotes recombinational
T1598 3572-3578 NN denotes repair
T1599 3579-3587 JJ denotes relative
T1600 3588-3590 IN denotes to
T1601 3591-3595 DT denotes that
T1602 3596-3604 VBN denotes observed
T1603 3605-3607 IN denotes in
T1604 3608-3613 JJ denotes other
T1605 3625-3630 NNS denotes lines
T1606 3614-3619 JJ denotes human
T1607 3620-3624 NN denotes cell
T1608 3630-3631 . denotes .
T1609 3631-3812 sentence denotes Conversely, the BRCA2 defect in CAPAN-1 could be fully responsible for the 100-fold defect in recombination if the level of BRCA2 complementation observed by Powell was incomplete.
T1610 3632-3642 RB denotes Conversely
T1611 3678-3680 VB denotes be
T1612 3642-3644 , denotes ,
T1613 3644-3647 DT denotes the
T1614 3654-3660 NN denotes defect
T1615 3648-3653 NN denotes BRCA2
T1616 3661-3663 IN denotes in
T1617 3664-3669 NN denotes CAPAN
T1618 3669-3670 HYPH denotes -
T1619 3670-3671 CD denotes 1
T1620 3672-3677 MD denotes could
T1621 3681-3686 RB denotes fully
T1622 3687-3698 JJ denotes responsible
T1623 3699-3702 IN denotes for
T1624 3703-3706 DT denotes the
T1625 3716-3722 NN denotes defect
T1626 3707-3715 JJ denotes 100-fold
T1627 3723-3725 IN denotes in
T1628 3726-3739 NN denotes recombination
T1629 3740-3742 IN denotes if
T1630 3797-3800 VBD denotes was
T1631 3743-3746 DT denotes the
T1632 3747-3752 NN denotes level
T1633 3753-3755 IN denotes of
T1634 3756-3761 NN denotes BRCA2
T1635 3762-3777 NN denotes complementation
T1636 3778-3786 VBN denotes observed
T1637 3787-3789 IN denotes by
T1638 3790-3796 NNP denotes Powell
T1639 3801-3811 JJ denotes incomplete
T1640 3811-3812 . denotes .
T1641 3812-4105 sentence denotes Furthermore, the discrepancy between the 100-fold difference between CAPAN-1 and the other human lines as compared with the fivefold to sixfold difference between the Brca2lex1/lex2cells and Brca2+/+ ES cells might simply be accounted for by the fact that Brca2lex1/lex2 is not a null allele.
T1642 3813-3824 RB denotes Furthermore
T1643 4038-4047 VBN denotes accounted
T1644 3824-3826 , denotes ,
T1645 3826-3829 DT denotes the
T1646 3830-3841 NN denotes discrepancy
T1647 3842-3849 IN denotes between
T1648 3850-3853 DT denotes the
T1649 3863-3873 NN denotes difference
T1650 3854-3862 JJ denotes 100-fold
T1651 3874-3881 IN denotes between
T1652 3882-3887 NN denotes CAPAN
T1653 3887-3888 HYPH denotes -
T1654 3888-3889 CD denotes 1
T1655 3890-3893 CC denotes and
T1656 3894-3897 DT denotes the
T1657 3910-3915 NNS denotes lines
T1658 3898-3903 JJ denotes other
T1659 3904-3909 JJ denotes human
T1660 3916-3918 IN denotes as
T1661 3919-3927 VBN denotes compared
T1662 3928-3932 IN denotes with
T1663 3933-3936 DT denotes the
T1664 3957-3967 NN denotes difference
T1665 3937-3945 JJ denotes fivefold
T1666 3949-3956 JJ denotes sixfold
T1667 3946-3948 IN denotes to
T1668 3968-3975 IN denotes between
T1669 3976-3979 DT denotes the
T1670 3994-3999 NNS denotes cells
T1671 3980-3989 NN denotes Brca2lex1
T1672 3990-3994 NN denotes lex2
T1673 3989-3990 HYPH denotes /
T1674 4000-4003 CC denotes and
T1675 4004-4009 NN denotes Brca2
T1676 4016-4021 NNS denotes cells
T1677 4009-4010 SYM denotes +
T1678 4010-4011 HYPH denotes /
T1679 4011-4012 SYM denotes +
T1680 4013-4015 NN denotes ES
T1681 4022-4027 MD denotes might
T1682 4028-4034 RB denotes simply
T1683 4035-4037 VB denotes be
T1684 4048-4051 IN denotes for
T1685 4052-4054 IN denotes by
T1686 4055-4058 DT denotes the
T1687 4059-4063 NN denotes fact
T1688 4064-4068 IN denotes that
T1689 4084-4086 VBZ denotes is
T1690 4069-4078 NN denotes Brca2lex1
T1691 4079-4083 NN denotes lex2
T1692 4078-4079 HYPH denotes /
T1693 4087-4090 RB denotes not
T1694 4091-4092 DT denotes a
T1695 4098-4104 NN denotes allele
T1696 4093-4097 JJ denotes null
T1697 4104-4105 . denotes .
T1698 4105-4212 sentence denotes Additional studies are likely to shed light on the efficiency of BRCA2-independent recombination pathways.
T1699 4106-4116 JJ denotes Additional
T1700 4117-4124 NNS denotes studies
T1701 4125-4128 VBP denotes are
T1702 4129-4135 JJ denotes likely
T1703 4136-4138 TO denotes to
T1704 4139-4143 VB denotes shed
T1705 4144-4149 NN denotes light
T1706 4150-4152 IN denotes on
T1707 4153-4156 DT denotes the
T1708 4157-4167 NN denotes efficiency
T1709 4168-4170 IN denotes of
T1710 4171-4176 NN denotes BRCA2
T1711 4177-4188 JJ denotes independent
T1712 4176-4177 HYPH denotes -
T1713 4203-4211 NNS denotes pathways
T1714 4189-4202 NN denotes recombination
T1715 4211-4212 . denotes .
T1716 4212-4346 sentence denotes Taken together, the results indicate that BRCA2 is indeed required for high levels of recombinational repair in both human and mouse.
T1717 4213-4218 VBN denotes Taken
T1718 4241-4249 VBP denotes indicate
T1719 4219-4227 RB denotes together
T1720 4227-4229 , denotes ,
T1721 4229-4232 DT denotes the
T1722 4233-4240 NNS denotes results
T1723 4250-4254 IN denotes that
T1724 4271-4279 VBN denotes required
T1725 4255-4260 NN denotes BRCA2
T1726 4261-4263 VBZ denotes is
T1727 4264-4270 RB denotes indeed
T1728 4280-4283 IN denotes for
T1729 4284-4288 JJ denotes high
T1730 4289-4295 NNS denotes levels
T1731 4296-4298 IN denotes of
T1732 4299-4314 JJ denotes recombinational
T1733 4315-4321 NN denotes repair
T1734 4322-4324 IN denotes in
T1735 4325-4329 CC denotes both
T1736 4340-4345 NN denotes mouse
T1737 4330-4335 JJ denotes human
T1738 4336-4339 CC denotes and
T1739 4345-4346 . denotes .
R564 T1002 T1003 nsubj Pierce,designed
R565 T1004 T1005 advmod et,al
R566 T1005 T1002 advmod al,Pierce
R567 T1006 T1003 aux have,designed
R568 T1007 T1008 det a,set
R569 T1008 T1003 dobj set,designed
R570 T1009 T1008 prep of,set
R571 T1010 T1011 compound recombination,substrates
R572 T1011 T1009 pobj substrates,of
R573 T1012 T1003 prep for,designed
R574 T1013 T1012 pcomp measuring,for
R575 T1014 T1015 det the,level
R576 T1015 T1013 dobj level,measuring
R577 T1016 T1015 prep of,level
R578 T1017 T1018 amod homologous,recombination
R579 T1018 T1016 pobj recombination,of
R580 T1019 T1020 advmod in,vivo
R581 T1020 T1013 advmod vivo,measuring
R582 T1021 T1022 punct (,Fig.
R583 T1022 T1003 parataxis Fig.,designed
R584 T1023 T1022 nummod 1,Fig.
R585 T1024 T1022 punct ),Fig.
R586 T1025 T1026 punct [,25
R587 T1026 T1003 parataxis 25,designed
R588 T1027 T1026 punct ],25
R589 T1028 T1003 punct .,designed
R590 T1030 T1031 det The,substrate
R591 T1031 T1033 nsubj substrate,contains
R592 T1032 T1031 compound DNA,substrate
R593 T1034 T1035 det a,pair
R594 T1035 T1033 dobj pair,contains
R595 T1036 T1035 prep of,pair
R596 T1037 T1038 amod mutated,genes
R597 T1038 T1036 pobj genes,of
R598 T1039 T1038 compound GFP,genes
R599 T1040 T1041 punct (,encodes
R600 T1041 T1035 parataxis encodes,pair
R601 T1042 T1041 nsubj GFP,encodes
R602 T1043 T1044 det the,protein
R603 T1044 T1041 dobj protein,encodes
R604 T1045 T1046 advmod easily,detected
R605 T1046 T1044 amod detected,protein
R606 T1047 T1044 amod green,protein
R607 T1048 T1044 amod fluorescent,protein
R608 T1049 T1041 punct ),encodes
R609 T1050 T1035 punct ", ",pair
R610 T1051 T1052 dep one,contains
R611 T1052 T1035 relcl contains,pair
R612 T1053 T1051 prep of,one
R613 T1054 T1053 pobj which,of
R614 T1055 T1056 det a,site
R615 T1056 T1052 dobj site,contains
R616 T1057 T1056 compound restriction,site
R617 T1058 T1056 prep for,site
R618 T1059 T1060 compound I,SceI
R619 T1060 T1058 pobj SceI,for
R620 T1061 T1060 punct -,SceI
R621 T1062 T1060 punct ", ",SceI
R622 T1063 T1064 det a,endonuclease
R623 T1064 T1060 appos endonuclease,SceI
R624 T1065 T1066 compound yeast,intron
R625 T1066 T1067 npadvmod intron,encoded
R626 T1067 T1064 amod encoded,endonuclease
R627 T1068 T1064 prep with,endonuclease
R628 T1069 T1070 det an,site
R629 T1070 T1068 pobj site,with
R630 T1071 T1072 nummod 18,pair
R631 T1072 T1070 compound pair,site
R632 T1073 T1072 compound base,pair
R633 T1074 T1070 compound recognition,site
R634 T1075 T1033 punct .,contains
R635 T1077 T1078 amod Transient,transfection
R636 T1078 T1079 nsubj transfection,results
R637 T1080 T1078 prep of,transfection
R638 T1081 T1082 det an,vector
R639 T1082 T1080 pobj vector,of
R640 T1083 T1084 compound I,SceI
R641 T1084 T1082 compound SceI,vector
R642 T1085 T1084 punct -,SceI
R643 T1086 T1082 compound expression,vector
R644 T1087 T1079 prep in,results
R645 T1088 T1089 det the,production
R646 T1089 T1087 pobj production,in
R647 T1090 T1089 prep of,production
R648 T1091 T1092 det a,DSB
R649 T1092 T1090 pobj DSB,of
R650 T1093 T1089 prep in,production
R651 T1094 T1095 det the,copy
R652 T1095 T1093 pobj copy,in
R653 T1096 T1095 amod first,copy
R654 T1097 T1095 amod mutated,copy
R655 T1098 T1095 prep of,copy
R656 T1099 T1098 pobj GFP,of
R657 T1100 T1079 punct .,results
R658 T1102 T1103 nsubj One,invade
R659 T1104 T1102 cc or,One
R660 T1105 T1106 nmod both,ends
R661 T1106 T1102 conj ends,One
R662 T1107 T1106 compound DNA,ends
R663 T1108 T1102 acl formed,One
R664 T1109 T1108 agent by,formed
R665 T1110 T1111 det the,break
R666 T1111 T1109 pobj break,by
R667 T1112 T1103 punct (,invade
R668 T1113 T1103 dep s,invade
R669 T1114 T1103 punct ),invade
R670 T1115 T1116 det the,sequence
R671 T1116 T1103 dobj sequence,invade
R672 T1117 T1116 amod homologous,sequence
R673 T1118 T1116 prep in,sequence
R674 T1119 T1120 det the,copy
R675 T1120 T1118 pobj copy,in
R676 T1121 T1120 amod second,copy
R677 T1122 T1123 amod mutant,GFP
R678 T1123 T1120 compound GFP,copy
R679 T1124 T1103 punct ", ",invade
R680 T1125 T1103 advcl resulting,invade
R681 T1126 T1125 prep in,resulting
R682 T1127 T1126 pobj repair,in
R683 T1128 T1127 prep of,repair
R684 T1129 T1130 det the,DSB
R685 T1130 T1128 pobj DSB,of
R686 T1131 T1127 prep via,repair
R687 T1132 T1133 det a,event
R688 T1133 T1131 pobj event,via
R689 T1134 T1135 npadvmod homology,mediated
R690 T1135 T1133 amod mediated,event
R691 T1136 T1135 punct -,mediated
R692 T1137 T1138 compound gene,conversion
R693 T1138 T1133 compound conversion,event
R694 T1139 T1103 punct .,invade
R695 T1141 T1142 det The,configuration
R696 T1142 T1143 nsubj configuration,is
R697 T1144 T1142 prep of,configuration
R698 T1145 T1146 det the,construct
R699 T1146 T1144 pobj construct,of
R700 T1147 T1146 compound GFP,construct
R701 T1148 T1143 acomp such,is
R702 T1149 T1150 mark that,results
R703 T1150 T1148 ccomp results,such
R704 T1151 T1152 npadvmod homology,mediated
R705 T1152 T1154 amod mediated,repair
R706 T1153 T1152 punct -,mediated
R707 T1154 T1150 nsubj repair,results
R708 T1155 T1150 advmod often,results
R709 T1156 T1150 prep in,results
R710 T1157 T1158 det the,formation
R711 T1158 T1156 pobj formation,in
R712 T1159 T1158 prep of,formation
R713 T1160 T1161 det a,copy
R714 T1161 T1159 pobj copy,of
R715 T1162 T1161 amod functional,copy
R716 T1163 T1161 prep of,copy
R717 T1164 T1163 pobj GFP,of
R718 T1165 T1143 punct .,is
R719 T1167 T1168 amod Such,events
R720 T1168 T1169 nsubjpass events,detected
R721 T1170 T1169 aux can,detected
R722 T1171 T1169 auxpass be,detected
R723 T1172 T1169 prep by,detected
R724 T1173 T1174 npadvmod fluorescence,activated
R725 T1174 T1176 amod activated,sorting
R726 T1175 T1174 punct -,activated
R727 T1176 T1178 compound sorting,analysis
R728 T1177 T1176 compound cell,sorting
R729 T1178 T1172 pobj analysis,by
R730 T1179 T1169 prep by,detected
R731 T1180 T1179 pobj virtue,by
R732 T1181 T1180 prep of,virtue
R733 T1182 T1183 poss their,expression
R734 T1183 T1181 pobj expression,of
R735 T1184 T1183 prep of,expression
R736 T1185 T1184 pobj GFP,of
R737 T1186 T1169 punct .,detected
R738 T1188 T1189 nsubj Moynahan,used
R739 T1190 T1191 advmod et,al
R740 T1191 T1188 advmod al,Moynahan
R741 T1192 T1193 punct [,24
R742 T1193 T1188 parataxis 24,Moynahan
R743 T1194 T1193 punct ],24
R744 T1195 T1189 aux have,used
R745 T1196 T1197 predet such,substrate
R746 T1197 T1189 dobj substrate,used
R747 T1198 T1197 det a,substrate
R748 T1199 T1200 compound GFP,recombination
R749 T1200 T1197 compound recombination,substrate
R750 T1201 T1202 aux to,demonstrate
R751 T1202 T1189 advcl demonstrate,used
R752 T1203 T1204 mark that,are
R753 T1204 T1202 ccomp are,demonstrate
R754 T1205 T1204 nsubj cells,are
R755 T1206 T1205 prep with,cells
R756 T1207 T1208 amod defective,protein
R757 T1208 T1206 pobj protein,with
R758 T1209 T1208 compound BRCA2,protein
R759 T1210 T1204 acomp deficient,are
R760 T1211 T1210 prep in,deficient
R761 T1212 T1213 poss their,ability
R762 T1213 T1211 pobj ability,in
R763 T1214 T1215 aux to,repair
R764 T1215 T1213 acl repair,ability
R765 T1216 T1217 det the,DSB
R766 T1217 T1215 dobj DSB,repair
R767 T1218 T1219 compound I,SceI
R768 T1219 T1221 npadvmod SceI,induced
R769 T1220 T1219 punct -,SceI
R770 T1221 T1217 amod induced,DSB
R771 T1222 T1221 punct -,induced
R772 T1223 T1215 prep through,repair
R773 T1224 T1225 amod homologous,recombination
R774 T1225 T1223 pobj recombination,through
R775 T1226 T1189 punct .,used
R776 T1228 T1229 nsubj Expression,resulted
R777 T1230 T1228 prep of,Expression
R778 T1231 T1232 compound I,SceI
R779 T1232 T1230 pobj SceI,of
R780 T1233 T1232 punct -,SceI
R781 T1234 T1229 prep in,resulted
R782 T1235 T1236 quantmod 1,1400
R783 T1236 T1239 nummod 1400,cells
R784 T1237 T1236 quantmod out,1400
R785 T1238 T1236 quantmod of,1400
R786 T1239 T1240 nsubj cells,producing
R787 T1240 T1234 pcomp producing,in
R788 T1241 T1240 dobj GFP,producing
R789 T1242 T1240 prep via,producing
R790 T1243 T1244 amod homologous,recombination
R791 T1244 T1242 pobj recombination,via
R792 T1245 T1244 prep in,recombination
R793 T1246 T1247 det the,line
R794 T1247 T1245 pobj line,in
R795 T1248 T1249 amod human,cell
R796 T1249 T1247 compound cell,line
R797 T1250 T1249 amod pancreatic,cell
R798 T1251 T1249 compound tumor,cell
R799 T1252 T1247 appos CAPAN,line
R800 T1253 T1252 punct -,CAPAN
R801 T1254 T1252 nummod 1,CAPAN
R802 T1255 T1229 punct .,resulted
R803 T1257 T1258 nmod CAPAN,cells
R804 T1258 T1261 nsubj cells,carry
R805 T1259 T1257 punct -,CAPAN
R806 T1260 T1257 nummod 1,CAPAN
R807 T1262 T1263 det a,deletion
R808 T1263 T1261 dobj deletion,carry
R809 T1264 T1263 prep of,deletion
R810 T1265 T1264 pobj BRCA2,of
R811 T1266 T1261 prep on,carry
R812 T1267 T1268 nummod one,homolog
R813 T1268 T1266 pobj homolog,on
R814 T1269 T1261 cc and,carry
R815 T1270 T1261 conj codes,carry
R816 T1271 T1270 prep for,codes
R817 T1272 T1273 det a,protein
R818 T1273 T1271 pobj protein,for
R819 T1274 T1273 acl truncated,protein
R820 T1275 T1274 prep at,truncated
R821 T1276 T1277 amod amino,acid
R822 T1277 T1275 pobj acid,at
R823 T1278 T1277 appos 1981,acid
R824 T1279 T1270 prep on,codes
R825 T1280 T1281 det the,homolog
R826 T1281 T1279 pobj homolog,on
R827 T1282 T1281 amod other,homolog
R828 T1283 T1261 punct .,carry
R829 T1285 T1286 det The,authors
R830 T1286 T1287 nsubj authors,indicate
R831 T1288 T1289 mark that,is
R832 T1289 T1287 ccomp is,indicate
R833 T1290 T1291 det the,level
R834 T1291 T1289 nsubj level,is
R835 T1292 T1291 prep of,level
R836 T1293 T1294 compound I,SceI
R837 T1294 T1296 npadvmod SceI,induced
R838 T1295 T1294 punct -,SceI
R839 T1296 T1298 amod induced,recombination
R840 T1297 T1296 punct -,induced
R841 T1298 T1292 pobj recombination,of
R842 T1299 T1291 prep in,level
R843 T1300 T1299 pobj CAPAN,in
R844 T1301 T1300 punct -,CAPAN
R845 T1302 T1300 nummod 1,CAPAN
R846 T1303 T1304 quantmod over,100-fold
R847 T1304 T1305 advmod 100-fold,less
R848 T1305 T1289 acomp less,is
R849 T1306 T1305 prep than,less
R850 T1307 T1306 pobj that,than
R851 T1308 T1307 acl seen,that
R852 T1309 T1308 advcl using,seen
R853 T1310 T1311 amod other,BRCA2+
R854 T1311 T1313 amod BRCA2+,lines
R855 T1312 T1311 punct (,BRCA2+
R856 T1313 T1309 dobj lines,using
R857 T1314 T1313 punct ),lines
R858 T1315 T1316 amod human,tumor
R859 T1316 T1317 compound tumor,cell
R860 T1317 T1313 compound cell,lines
R861 T1318 T1287 punct .,indicate
R862 T1320 T1321 det The,lines
R863 T1321 T1323 nsubj lines,are
R864 T1322 T1321 amod different,lines
R865 T1324 T1321 acl examined,lines
R866 T1325 T1323 punct ", ",are
R867 T1326 T1323 advmod however,are
R868 T1327 T1323 punct ", ",are
R869 T1328 T1329 advmod very,likely
R870 T1329 T1323 acomp likely,are
R871 T1330 T1331 aux to,differ
R872 T1331 T1329 xcomp differ,likely
R873 T1332 T1331 advmod genetically,differ
R874 T1333 T1331 prep from,differ
R875 T1334 T1335 nmod CAPAN,cells
R876 T1335 T1333 pobj cells,from
R877 T1336 T1334 punct -,CAPAN
R878 T1337 T1334 nummod 1,CAPAN
R879 T1338 T1339 preconj not,at
R880 T1339 T1331 prep at,differ
R881 T1340 T1338 advmod only,not
R882 T1341 T1342 det the,locus
R883 T1342 T1339 pobj locus,at
R884 T1343 T1342 compound BRCA2,locus
R885 T1344 T1339 punct ", ",at
R886 T1345 T1339 cc but,at
R887 T1346 T1345 advmod also,but
R888 T1347 T1339 conj at,at
R889 T1348 T1349 det a,number
R890 T1349 T1347 pobj number,at
R891 T1350 T1351 advmod very,large
R892 T1351 T1349 amod large,number
R893 T1352 T1349 prep of,number
R894 T1353 T1354 amod additional,loci
R895 T1354 T1352 pobj loci,of
R896 T1355 T1323 punct .,are
R897 T1357 T1358 nsubj This,raises
R898 T1359 T1360 det the,possibility
R899 T1360 T1358 dobj possibility,raises
R900 T1361 T1362 mark that,be
R901 T1362 T1360 acl be,possibility
R902 T1363 T1362 nsubj some,be
R903 T1364 T1363 cc or,some
R904 T1365 T1366 advmod even,all
R905 T1366 T1363 conj all,some
R906 T1367 T1363 prep of,some
R907 T1368 T1369 det the,defect
R908 T1369 T1367 pobj defect,of
R909 T1370 T1369 amod recombinational,defect
R910 T1371 T1369 compound repair,defect
R911 T1372 T1369 acl seen,defect
R912 T1373 T1372 prep in,seen
R913 T1374 T1373 pobj CAPAN,in
R914 T1375 T1374 punct -,CAPAN
R915 T1376 T1374 nummod 1,CAPAN
R916 T1377 T1362 aux could,be
R917 T1378 T1362 prep due,be
R918 T1379 T1378 pcomp to,due
R919 T1380 T1378 pobj mutations,due
R920 T1381 T1380 prep at,mutations
R921 T1382 T1383 amod non-BRCA2,loci
R922 T1383 T1381 pobj loci,at
R923 T1384 T1358 punct .,raises
R924 T1386 T1387 mark While,were
R925 T1387 T1391 advcl were,argue
R926 T1388 T1387 nsubj Moynahan,were
R927 T1389 T1390 advmod et,al
R928 T1390 T1388 advmod al,Moynahan
R929 T1392 T1387 acomp careful,were
R930 T1393 T1394 aux to,point
R931 T1394 T1392 xcomp point,careful
R932 T1395 T1394 prt out,point
R933 T1396 T1397 det this,problem
R934 T1397 T1394 dobj problem,point
R935 T1398 T1391 punct ", ",argue
R936 T1399 T1400 nummod two,sets
R937 T1400 T1391 nsubj sets,argue
R938 T1401 T1400 prep of,sets
R939 T1402 T1401 pobj results,of
R940 T1403 T1391 prep against,argue
R941 T1404 T1405 det the,possibility
R942 T1405 T1403 pobj possibility,against
R943 T1406 T1407 mark that,is
R944 T1407 T1405 acl is,possibility
R945 T1408 T1409 det the,deficiency
R946 T1409 T1407 nsubj deficiency,is
R947 T1410 T1409 amod recombinational,deficiency
R948 T1411 T1409 compound repair,deficiency
R949 T1412 T1409 prep of,deficiency
R950 T1413 T1414 nmod CAPAN,cells
R951 T1414 T1412 pobj cells,of
R952 T1415 T1413 punct -,CAPAN
R953 T1416 T1413 nummod 1,CAPAN
R954 T1417 T1418 advmod completely,independent
R955 T1418 T1407 acomp independent,is
R956 T1419 T1418 prep of,independent
R957 T1420 T1421 poss its,defect
R958 T1421 T1419 pobj defect,of
R959 T1422 T1421 prep in,defect
R960 T1423 T1422 pobj BRCA2,in
R961 T1424 T1391 punct .,argue
R962 T1426 T1427 advmod First,measured
R963 T1428 T1427 punct ", ",measured
R964 T1429 T1427 prep in,measured
R965 T1430 T1431 det the,study
R966 T1431 T1429 pobj study,in
R967 T1432 T1431 amod same,study
R968 T1433 T1434 punct [,24
R969 T1434 T1431 parataxis 24,study
R970 T1435 T1434 punct ],24
R971 T1436 T1427 punct ", ",measured
R972 T1437 T1427 nsubjpass recombination,measured
R973 T1438 T1437 prep in,recombination
R974 T1439 T1440 det a,line
R975 T1440 T1438 pobj line,in
R976 T1441 T1440 compound mouse,line
R977 T1442 T1440 compound ES,line
R978 T1443 T1440 compound cell,line
R979 T1444 T1445 dep that,expresses
R980 T1445 T1440 relcl expresses,line
R981 T1446 T1447 advmod only,protein
R982 T1447 T1445 dobj protein,expresses
R983 T1448 T1447 amod truncated,protein
R984 T1449 T1447 compound BRCA2,protein
R985 T1450 T1427 auxpass was,measured
R986 T1451 T1427 punct .,measured
R987 T1453 T1454 det This,line
R988 T1454 T1455 nsubjpass line,found
R989 T1456 T1455 auxpass was,found
R990 T1457 T1458 aux to,have
R991 T1458 T1455 xcomp have,found
R992 T1459 T1460 amod lower,efficiency
R993 T1460 T1458 dobj efficiency,have
R994 T1461 T1460 compound recombination,efficiency
R995 T1462 T1460 prep than,efficiency
R996 T1463 T1464 amod isogenic,cells
R997 T1464 T1462 pobj cells,than
R998 T1465 T1464 acl expressing,cells
R999 T1466 T1467 amod full,length
R1000 T1467 T1469 compound length,BRCA2
R1001 T1468 T1467 punct -,length
R1002 T1469 T1465 dobj BRCA2,expressing
R1003 T1470 T1471 punct (,was
R1004 T1471 T1469 parataxis was,BRCA2
R1005 T1472 T1473 det the,defect
R1006 T1473 T1471 nsubj defect,was
R1007 T1474 T1473 acl observed,defect
R1008 T1475 T1476 advmod about,sixfold
R1009 T1476 T1471 advmod sixfold,was
R1010 T1477 T1476 advmod fivefold,sixfold
R1011 T1478 T1476 quantmod to,sixfold
R1012 T1479 T1471 punct ),was
R1013 T1480 T1455 punct .,found
R1014 T1482 T1483 advmod Second,was
R1015 T1484 T1483 punct ", ",was
R1016 T1485 T1483 prep in,was
R1017 T1486 T1487 det an,study
R1018 T1487 T1485 pobj study,in
R1019 T1488 T1487 amod independent,study
R1020 T1489 T1483 punct ", ",was
R1021 T1490 T1483 nsubj Powell,was
R1022 T1491 T1483 acomp able,was
R1023 T1492 T1493 aux to,compare
R1024 T1493 T1491 xcomp compare,able
R1025 T1494 T1493 dobj derivatives,compare
R1026 T1495 T1494 prep of,derivatives
R1027 T1496 T1495 pobj CAPAN,of
R1028 T1497 T1496 punct -,CAPAN
R1029 T1498 T1496 nummod 1,CAPAN
R1030 T1499 T1500 dep that,differed
R1031 T1500 T1494 relcl differed,derivatives
R1032 T1501 T1500 advmod only,differed
R1033 T1502 T1500 prep in,differed
R1034 T1503 T1504 poss their,ability
R1035 T1504 T1502 pobj ability,in
R1036 T1505 T1506 aux to,express
R1037 T1506 T1504 acl express,ability
R1038 T1507 T1508 amod full,length
R1039 T1508 T1510 compound length,protein
R1040 T1509 T1508 punct -,length
R1041 T1510 T1506 dobj protein,express
R1042 T1511 T1510 compound BRCA2,protein
R1043 T1512 T1513 punct (,Powell
R1044 T1513 T1493 meta Powell,compare
R1045 T1514 T1513 compound S.,Powell
R1046 T1515 T1513 punct ", ",Powell
R1047 T1516 T1517 amod personal,communication
R1048 T1517 T1513 dep communication,Powell
R1049 T1518 T1513 punct ", ",Powell
R1050 T1519 T1513 npadvmod 2001,Powell
R1051 T1520 T1513 punct ),Powell
R1052 T1521 T1483 punct .,was
R1053 T1523 T1524 prep In,yielded
R1054 T1525 T1526 det these,experiments
R1055 T1526 T1523 pobj experiments,In
R1056 T1527 T1524 punct ", ",yielded
R1057 T1528 T1529 det the,derivative
R1058 T1529 T1524 nsubj derivative,yielded
R1059 T1530 T1529 acl expressing,derivative
R1060 T1531 T1532 amod full,length
R1061 T1532 T1534 compound length,BRCA2
R1062 T1533 T1532 punct -,length
R1063 T1534 T1530 dobj BRCA2,expressing
R1064 T1535 T1536 advmod 10-fold,more
R1065 T1536 T1537 amod more,recombinants
R1066 T1537 T1524 dobj recombinants,yielded
R1067 T1538 T1537 prep than,recombinants
R1068 T1539 T1538 pobj controls,than
R1069 T1540 T1539 acl expressing,controls
R1070 T1541 T1542 advmod only,BRCA2
R1071 T1542 T1540 dobj BRCA2,expressing
R1072 T1543 T1542 amod truncated,BRCA2
R1073 T1544 T1545 punct (,Powell
R1074 T1545 T1524 meta Powell,yielded
R1075 T1546 T1545 compound S.,Powell
R1076 T1547 T1545 punct ", ",Powell
R1077 T1548 T1549 amod personal,communication
R1078 T1549 T1545 dep communication,Powell
R1079 T1550 T1545 punct ", ",Powell
R1080 T1551 T1545 dep 2001,Powell
R1081 T1552 T1545 punct ),Powell
R1082 T1553 T1524 punct .,yielded
R1083 T1555 T1556 mark While,was
R1084 T1556 T1563 advcl was,raise
R1085 T1557 T1558 det the,design
R1086 T1558 T1556 nsubj design,was
R1087 T1559 T1558 amod experimental,design
R1088 T1560 T1558 prep of,design
R1089 T1561 T1562 det these,experiments
R1090 T1562 T1560 pobj experiments,of
R1091 T1564 T1565 advmod somewhat,different
R1092 T1565 T1556 acomp different,was
R1093 T1566 T1565 prep from,different
R1094 T1567 T1566 pobj that,from
R1095 T1568 T1567 prep of,that
R1096 T1569 T1570 compound Moyna,han
R1097 T1570 T1568 pobj han,of
R1098 T1571 T1570 punct -,han
R1099 T1572 T1573 advmod et,al
R1100 T1573 T1570 advmod al,han
R1101 T1574 T1575 punct [,24
R1102 T1575 T1570 parataxis 24,han
R1103 T1576 T1575 punct ],24
R1104 T1577 T1563 punct ", ",raise
R1105 T1578 T1579 det the,results
R1106 T1579 T1563 nsubj results,raise
R1107 T1580 T1581 det the,possibility
R1108 T1581 T1563 dobj possibility,raise
R1109 T1582 T1583 mark that,have
R1110 T1583 T1581 acl have,possibility
R1111 T1584 T1585 nmod CAPAN,cells
R1112 T1585 T1583 nsubj cells,have
R1113 T1586 T1584 punct -,CAPAN
R1114 T1587 T1584 nummod 1,CAPAN
R1115 T1588 T1589 amod more,one
R1116 T1589 T1591 nummod one,mutation
R1117 T1590 T1589 quantmod than,one
R1118 T1591 T1583 dobj mutation,have
R1119 T1592 T1593 dep that,lowers
R1120 T1593 T1591 relcl lowers,mutation
R1121 T1594 T1595 det the,efficiency
R1122 T1595 T1593 dobj efficiency,lowers
R1123 T1596 T1595 prep of,efficiency
R1124 T1597 T1598 amod recombinational,repair
R1125 T1598 T1596 pobj repair,of
R1126 T1599 T1598 amod relative,repair
R1127 T1600 T1599 prep to,relative
R1128 T1601 T1600 pobj that,to
R1129 T1602 T1601 acl observed,that
R1130 T1603 T1602 prep in,observed
R1131 T1604 T1605 amod other,lines
R1132 T1605 T1603 pobj lines,in
R1133 T1606 T1605 amod human,lines
R1134 T1607 T1605 compound cell,lines
R1135 T1608 T1563 punct .,raise
R1136 T1610 T1611 advmod Conversely,be
R1137 T1612 T1611 punct ", ",be
R1138 T1613 T1614 det the,defect
R1139 T1614 T1611 nsubj defect,be
R1140 T1615 T1614 compound BRCA2,defect
R1141 T1616 T1614 prep in,defect
R1142 T1617 T1616 pobj CAPAN,in
R1143 T1618 T1617 punct -,CAPAN
R1144 T1619 T1617 nummod 1,CAPAN
R1145 T1621 T1622 advmod fully,responsible
R1146 T1622 T1611 acomp responsible,be
R1147 T1623 T1622 prep for,responsible
R1148 T1624 T1625 det the,defect
R1149 T1625 T1623 pobj defect,for
R1150 T1620 T1611 aux could,be
R1151 T1627 T1625 prep in,defect
R1152 T1628 T1627 pobj recombination,in
R1153 T1626 T1625 amod 100-fold,defect
R1154 T1630 T1611 advcl was,be
R1155 T1631 T1632 det the,level
R1156 T1629 T1630 mark if,was
R1157 T1633 T1632 prep of,level
R1158 T1634 T1635 compound BRCA2,complementation
R1159 T1632 T1630 nsubj level,was
R1160 T1636 T1632 acl observed,level
R1161 T1637 T1636 agent by,observed
R1162 T1638 T1637 pobj Powell,by
R1163 T1639 T1630 acomp incomplete,was
R1164 T1635 T1633 pobj complementation,of
R1165 T1642 T1643 advmod Furthermore,accounted
R1166 T1640 T1611 punct .,be
R1167 T1644 T1643 punct ", ",accounted
R1168 T1645 T1646 det the,discrepancy
R1169 T1647 T1646 prep between,discrepancy
R1170 T1648 T1649 det the,difference
R1171 T1646 T1643 nsubjpass discrepancy,accounted
R1172 T1650 T1649 amod 100-fold,difference
R1173 T1651 T1649 prep between,difference
R1174 T1649 T1647 pobj difference,between
R1175 T1653 T1652 punct -,CAPAN
R1176 T1654 T1652 nummod 1,CAPAN
R1177 T1652 T1651 pobj CAPAN,between
R1178 T1656 T1657 det the,lines
R1179 T1657 T1652 conj lines,CAPAN
R1180 T1655 T1652 cc and,CAPAN
R1181 T1659 T1657 amod human,lines
R1182 T1660 T1646 prep as,discrepancy
R1183 T1658 T1657 amod other,lines
R1184 T1662 T1661 prep with,compared
R1185 T1661 T1660 prep compared,as
R1186 T1664 T1662 pobj difference,with
R1187 T1663 T1664 det the,difference
R1188 T1666 T1664 nummod sixfold,difference
R1189 T1665 T1666 amod fivefold,sixfold
R1190 T1668 T1664 prep between,difference
R1191 T1669 T1670 det the,cells
R1192 T1667 T1666 quantmod to,sixfold
R1193 T1671 T1672 compound Brca2lex1,lex2
R1194 T1672 T1670 compound lex2,cells
R1195 T1670 T1668 pobj cells,between
R1196 T1674 T1670 cc and,cells
R1197 T1675 T1676 nmod Brca2,cells
R1198 T1673 T1672 punct /,lex2
R1199 T1677 T1675 punct +,Brca2
R1200 T1678 T1675 punct /,Brca2
R1201 T1679 T1675 punct +,Brca2
R1202 T1676 T1670 conj cells,cells
R1203 T1681 T1643 aux might,accounted
R1204 T1682 T1643 advmod simply,accounted
R1205 T1680 T1676 compound ES,cells
R1206 T1684 T1643 prep for,accounted
R1207 T1685 T1643 prep by,accounted
R1208 T1683 T1643 auxpass be,accounted
R1209 T1687 T1685 pobj fact,by
R1210 T1688 T1689 mark that,is
R1211 T1686 T1687 det the,fact
R1212 T1690 T1691 compound Brca2lex1,lex2
R1213 T1691 T1689 nsubj lex2,is
R1214 T1689 T1687 acl is,fact
R1215 T1693 T1689 neg not,is
R1216 T1694 T1695 det a,allele
R1217 T1692 T1691 punct /,lex2
R1218 T1696 T1695 amod null,allele
R1219 T1697 T1643 punct .,accounted
R1220 T1695 T1689 attr allele,is
R1221 T1699 T1700 amod Additional,studies
R1222 T1700 T1701 nsubj studies,are
R1223 T1702 T1701 acomp likely,are
R1224 T1704 T1702 xcomp shed,likely
R1225 T1705 T1704 dobj light,shed
R1226 T1703 T1704 aux to,shed
R1227 T1707 T1708 det the,efficiency
R1228 T1708 T1706 pobj efficiency,on
R1229 T1706 T1704 prep on,shed
R1230 T1710 T1711 npadvmod BRCA2,independent
R1231 T1711 T1713 amod independent,pathways
R1232 T1709 T1708 prep of,efficiency
R1233 T1713 T1709 pobj pathways,of
R1234 T1714 T1713 compound recombination,pathways
R1235 T1712 T1711 punct -,independent
R1236 T1719 T1717 advmod together,Taken
R1237 T1715 T1701 punct .,are
R1238 T1720 T1718 punct ", ",indicate
R1239 T1717 T1718 advcl Taken,indicate
R1240 T1722 T1718 nsubj results,indicate
R1241 T1721 T1722 det the,results
R1242 T1724 T1718 ccomp required,indicate
R1243 T1725 T1724 nsubjpass BRCA2,required
R1244 T1723 T1724 mark that,required
R1245 T1727 T1724 advmod indeed,required
R1246 T1728 T1724 prep for,required
R1247 T1726 T1724 auxpass is,required
R1248 T1730 T1728 pobj levels,for
R1249 T1729 T1730 amod high,levels
R1250 T1732 T1733 amod recombinational,repair
R1251 T1733 T1731 pobj repair,of
R1252 T1731 T1730 prep of,levels
R1253 T1735 T1736 preconj both,mouse
R1254 T1734 T1724 prep in,required
R1255 T1737 T1736 amod human,mouse
R1256 T1738 T1736 cc and,mouse
R1257 T1736 T1734 pobj mouse,in
R1258 T1739 T1718 punct .,indicate