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PMC:138691 / 1332-3109 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T775 108-130 GO_EXT:0000150 denotes homologous recombinase
T776 131-136 PR_EXT:000013672 denotes RAD51
T777 139-148 GO_PATO_EXT:biological_localization_process_or_quality denotes localizes
T778 155-162 GO:0005634 denotes nuclear
T779 174-179 PR_EXT:000004803 denotes BRCA1
T780 249-254 PR_EXT:000004803 denotes BRCA1
T781 259-264 PR_EXT:000004804 denotes BRCA2
T782 281-296 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T783 281-317 GO:0000725 denotes recombinational repair of DNA damage
T784 307-310 CHEBI_SO_EXT:DNA denotes DNA
T785 319-324 PR_EXT:000004803 denotes BRCA1
T786 329-334 PR_EXT:000004804 denotes BRCA2
T787 349-356 GO:0005634 denotes nuclear
T788 373-380 GO:0051320 denotes S phase
T789 403-406 CHEBI_SO_EXT:DNA denotes DNA
T790 403-422 CHEBI_EXT:50902 denotes DNA damaging agents
T791 467-476 _FRAGMENT denotes repair of
T792 501-511 GO:0006281 denotes DNA damage
T793 501-504 CHEBI_SO_EXT:DNA denotes DNA
T794 524-528 CL_GO_EXT:cell denotes Cell
T795 555-560 PR_EXT:000004803 denotes BRCA1
T796 564-569 PR_EXT:000004804 denotes BRCA2
T797 655-659 CL_GO_EXT:cell denotes cell
T798 679-694 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T799 679-701 GO:0000725 denotes recombinational repair
T800 722-727 PR_EXT:000004804 denotes BRCA2
T801 747-752 PR_EXT:000013672 denotes RAD51
T802 753-764 GO_EXT:recombinase denotes recombinase
T803 776-783 CHEBI_PR_EXT:protein denotes protein
T804 784-791 CHEBI_PR_EXT:protein denotes protein
T805 869-874 PR_EXT:000004803 denotes BRCA1
T806 879-884 PR_EXT:000013672 denotes RAD51
T807 959-966 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T808 970-975 PR_EXT:000004804 denotes BRCA2
T809 1003-1008 PR_EXT:000013672 denotes RAD51
T810 1022-1027 CL_GO_EXT:cell denotes Cells
T811 1036-1041 PR_EXT:000004803 denotes BRCA1
T812 1075-1082 GO:0005634 denotes nuclear
T813 1083-1088 PR_EXT:000013672 denotes RAD51
T814 1140-1148 CHEBI_PR_EXT:protein denotes proteins
T815 1170-1182 _FRAGMENT denotes formation of
T816 1195-1204 GO:0065003 denotes complexes
T817 1183-1194 GO_EXT:recombinase denotes recombinase
T818 1195-1204 GO:0032991 denotes complexes
T819 1221-1224 CHEBI_SO_EXT:DNA denotes DNA
T820 1250-1257 SO_EXT:0000704 denotes genetic
T821 1274-1287 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T822 1314-1319 PR_EXT:000004803 denotes Brca1
T823 1319-1320 SO_EXT:sequence_nullness_or_absence denotes -
T824 1321-1322 SO_EXT:sequence_nullness_or_absence denotes -
T825 1323-1332 UBERON:0000922 denotes embryonic
T826 1323-1337 _FRAGMENT denotes embryonic stem
T827 1343-1348 CL:0002322 denotes cells
T828 1339-1341 _FRAGMENT denotes ES
T829 1343-1348 CL_GO_EXT:cell denotes cells
T830 1366-1381 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T831 1366-1381 _FRAGMENT denotes recombinational
T832 1386-1392 GO:0000725 denotes repair
T833 1382-1392 GO:0006302 denotes DSB repair
T834 1452-1457 PR_EXT:000004803 denotes BRCA1
T835 1462-1467 PR_EXT:000004804 denotes BRCA2
T836 1527-1530 CHEBI_SO_EXT:DNA denotes DNA
T837 1557-1562 PR_EXT:000004803 denotes BRCA1
T838 1567-1572 PR_EXT:000004804 denotes BRCA2
T839 1576-1582 GO:0006281 denotes repair
T840 1594-1599 CL_GO_EXT:cell denotes cells
T841 1628-1633 PR_EXT:000004804 denotes BRCA2
T842 1640-1645 PR_EXT:000004803 denotes BRCA1
T843 1673-1688 GO_SO_EXT:sequence_rearrangement_process denotes recombinational
T844 1673-1695 GO:0000725 denotes recombinational repair
R558 T792 T791 _lexicallyChainedTo DNA damage,repair of
R559 T816 T815 _lexicallyChainedTo complexes,formation of
R560 T827 T826 _lexicallyChainedTo cells,embryonic stem
R561 T827 T828 _lexicallyChainedTo cells,ES
R562 T832 T831 _lexicallyChainedTo repair,recombinational

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T392 131-136 PR:000013672 denotes RAD51
T393 155-162 GO:0005634 denotes nuclear
T394 174-179 PR:000004803 denotes BRCA1
T395 249-254 PR:000004803 denotes BRCA1
T396 259-264 PR:000004804 denotes BRCA2
T397 281-317 GO:0000725 denotes recombinational repair of DNA damage
T398 319-324 PR:000004803 denotes BRCA1
T399 329-334 PR:000004804 denotes BRCA2
T400 349-356 GO:0005634 denotes nuclear
T401 373-380 GO:0051320 denotes S phase
T402 403-422 CHEBI:50902 denotes DNA damaging agents
T403 467-476 _FRAGMENT denotes repair of
T404 501-511 GO:0006281 denotes DNA damage
T405 555-560 PR:000004803 denotes BRCA1
T406 564-569 PR:000004804 denotes BRCA2
T407 679-701 GO:0000725 denotes recombinational repair
T408 722-727 PR:000004804 denotes BRCA2
T409 747-752 PR:000013672 denotes RAD51
T410 869-874 PR:000004803 denotes BRCA1
T411 879-884 PR:000013672 denotes RAD51
T412 970-975 PR:000004804 denotes BRCA2
T413 1003-1008 PR:000013672 denotes RAD51
T414 1036-1041 PR:000004803 denotes BRCA1
T415 1075-1082 GO:0005634 denotes nuclear
T416 1083-1088 PR:000013672 denotes RAD51
T417 1170-1182 _FRAGMENT denotes formation of
T418 1195-1204 GO:0065003 denotes complexes
T419 1195-1204 GO:0032991 denotes complexes
T420 1250-1257 SO:0000704 denotes genetic
T421 1314-1319 PR:000004803 denotes Brca1
T422 1323-1332 UBERON:0000922 denotes embryonic
T423 1323-1337 _FRAGMENT denotes embryonic stem
T424 1343-1348 CL:0002322 denotes cells
T425 1339-1341 _FRAGMENT denotes ES
T426 1366-1381 _FRAGMENT denotes recombinational
T427 1386-1392 GO:0000725 denotes repair
T428 1382-1392 GO:0006302 denotes DSB repair
T429 1452-1457 PR:000004803 denotes BRCA1
T430 1462-1467 PR:000004804 denotes BRCA2
T431 1557-1562 PR:000004803 denotes BRCA1
T432 1567-1572 PR:000004804 denotes BRCA2
T433 1576-1582 GO:0006281 denotes repair
T434 1628-1633 PR:000004804 denotes BRCA2
T435 1640-1645 PR:000004803 denotes BRCA1
T436 1673-1695 GO:0000725 denotes recombinational repair
R236 T404 T403 _lexicallyChainedTo DNA damage,repair of
R237 T418 T417 _lexicallyChainedTo complexes,formation of
R238 T424 T423 _lexicallyChainedTo cells,embryonic stem
R239 T424 T425 _lexicallyChainedTo cells,ES
R240 T427 T426 _lexicallyChainedTo repair,recombinational

craft-sa-dev

Id Subject Object Predicate Lexical cue
T437 50-59 VBG denotes Following
T438 221-229 VBN denotes provided
T439 60-63 DT denotes the
T440 73-82 NN denotes discovery
T441 64-72 NN denotes landmark
T442 83-85 IN denotes by
T443 86-92 NNP denotes Scully
T444 93-95 FW denotes et
T445 96-98 FW denotes al
T446 99-103 IN denotes that
T447 137-148 VBZ denotes colocalizes
T448 104-107 DT denotes the
T449 131-136 NN denotes RAD51
T450 108-118 JJ denotes homologous
T451 119-130 NN denotes recombinase
T452 149-151 IN denotes at
T453 152-162 JJ denotes subnuclear
T454 163-168 NNS denotes sites
T455 169-173 IN denotes with
T456 174-179 NN denotes BRCA1
T457 180-181 -LRB- denotes [
T458 181-182 CD denotes 9
T459 182-183 -RRB- denotes ]
T460 183-185 , denotes ,
T461 185-186 DT denotes a
T462 187-193 NN denotes number
T463 194-196 IN denotes of
T464 197-207 JJ denotes additional
T465 208-215 NNS denotes results
T466 216-220 VBP denotes have
T467 230-238 NN denotes evidence
T468 239-243 IN denotes that
T469 269-277 VBN denotes involved
T470 244-248 CC denotes both
T471 249-254 NN denotes BRCA1
T472 255-258 CC denotes and
T473 259-264 NN denotes BRCA2
T474 265-268 VBP denotes are
T475 278-280 IN denotes in
T476 281-296 JJ denotes recombinational
T477 297-303 NN denotes repair
T478 304-306 IN denotes of
T479 307-310 NN denotes DNA
T480 311-317 NN denotes damage
T481 317-318 . denotes .
T482 318-433 sentence denotes BRCA1 and BRCA2 form discrete nuclear foci during the S phase and after exposure to DNA damaging agents [9,10,11].
T483 319-324 NN denotes BRCA1
T484 335-339 VBP denotes form
T485 325-328 CC denotes and
T486 329-334 NN denotes BRCA2
T487 340-348 JJ denotes discrete
T488 357-361 NNS denotes foci
T489 349-356 JJ denotes nuclear
T490 362-368 IN denotes during
T491 369-372 DT denotes the
T492 375-380 NN denotes phase
T493 373-374 NN denotes S
T494 381-384 CC denotes and
T495 385-390 IN denotes after
T496 391-399 NN denotes exposure
T497 400-402 IN denotes to
T498 403-406 NN denotes DNA
T499 407-415 VBG denotes damaging
T500 416-422 NNS denotes agents
T501 423-424 -LRB- denotes [
T502 429-431 CD denotes 11
T503 424-425 CD denotes 9
T504 425-426 , denotes ,
T505 426-428 CD denotes 10
T506 428-429 , denotes ,
T507 431-432 -RRB- denotes ]
T508 432-433 . denotes .
T509 433-523 sentence denotes These foci are probably sites of repair of spontaneous and induced DNA damage [12,13,14].
T510 434-439 DT denotes These
T511 440-444 NNS denotes foci
T512 445-448 VBP denotes are
T513 449-457 RB denotes probably
T514 458-463 NNS denotes sites
T515 464-466 IN denotes of
T516 467-473 NN denotes repair
T517 474-476 IN denotes of
T518 477-488 JJ denotes spontaneous
T519 505-511 NN denotes damage
T520 489-492 CC denotes and
T521 493-500 JJ denotes induced
T522 501-504 NN denotes DNA
T523 512-513 -LRB- denotes [
T524 519-521 CD denotes 14
T525 513-515 CD denotes 12
T526 515-516 , denotes ,
T527 516-518 CD denotes 13
T528 518-519 , denotes ,
T529 521-522 -RRB- denotes ]
T530 522-523 . denotes .
T531 523-721 sentence denotes Cell lines defective in either BRCA1 or BRCA2 are sensitive to damaging agents that form double-strand breaks (DSBs), as are other cell lines defective in recombinational repair (reviewed in [15]).
T532 524-528 NN denotes Cell
T533 529-534 NNS denotes lines
T534 570-573 VBP denotes are
T535 535-544 JJ denotes defective
T536 545-547 IN denotes in
T537 548-554 CC denotes either
T538 555-560 NN denotes BRCA1
T539 561-563 CC denotes or
T540 564-569 NN denotes BRCA2
T541 574-583 JJ denotes sensitive
T542 584-586 IN denotes to
T543 587-595 VBG denotes damaging
T544 596-602 NNS denotes agents
T545 603-607 WDT denotes that
T546 608-612 VBP denotes form
T547 613-619 JJ denotes double
T548 620-626 JJ denotes strand
T549 619-620 HYPH denotes -
T550 627-633 NNS denotes breaks
T551 634-635 -LRB- denotes (
T552 635-639 NNS denotes DSBs
T553 639-640 -RRB- denotes )
T554 640-642 , denotes ,
T555 642-644 IN denotes as
T556 645-648 VBP denotes are
T557 649-654 JJ denotes other
T558 660-665 NNS denotes lines
T559 655-659 NN denotes cell
T560 666-675 JJ denotes defective
T561 676-678 IN denotes in
T562 679-694 JJ denotes recombinational
T563 695-701 NN denotes repair
T564 702-703 -LRB- denotes (
T565 703-711 VBN denotes reviewed
T566 712-714 IN denotes in
T567 715-716 -LRB- denotes [
T568 716-718 CD denotes 15
T569 718-719 -RRB- denotes ]
T570 719-720 -RRB- denotes )
T571 720-721 . denotes .
T572 721-815 sentence denotes BRCA2 interacts with the RAD51 recombinase via direct protein-protein contacts [16,17,18,19].
T573 722-727 NN denotes BRCA2
T574 728-737 VBZ denotes interacts
T575 738-742 IN denotes with
T576 743-746 DT denotes the
T577 753-764 NN denotes recombinase
T578 747-752 NN denotes RAD51
T579 765-768 IN denotes via
T580 769-775 JJ denotes direct
T581 792-800 NNS denotes contacts
T582 776-783 NN denotes protein
T583 784-791 NN denotes protein
T584 783-784 HYPH denotes -
T585 801-802 -LRB- denotes [
T586 811-813 CD denotes 19
T587 802-804 CD denotes 16
T588 804-805 , denotes ,
T589 805-807 CD denotes 17
T590 807-808 , denotes ,
T591 808-810 CD denotes 18
T592 810-811 , denotes ,
T593 813-814 -RRB- denotes ]
T594 814-815 . denotes .
T595 815-950 sentence denotes Biochemical analysis also showed interaction between BRCA1 and RAD51, although these detected interactions may have been indirect [9].
T596 816-827 JJ denotes Biochemical
T597 828-836 NN denotes analysis
T598 842-848 VBD denotes showed
T599 837-841 RB denotes also
T600 849-860 NN denotes interaction
T601 861-868 IN denotes between
T602 869-874 NN denotes BRCA1
T603 875-878 CC denotes and
T604 879-884 NN denotes RAD51
T605 884-886 , denotes ,
T606 886-894 IN denotes although
T607 932-936 VBN denotes been
T608 895-900 DT denotes these
T609 910-922 NNS denotes interactions
T610 901-909 VBN denotes detected
T611 923-926 MD denotes may
T612 927-931 VB denotes have
T613 937-945 JJ denotes indirect
T614 946-947 -LRB- denotes [
T615 947-948 CD denotes 9
T616 948-949 -RRB- denotes ]
T617 949-950 . denotes .
T618 950-1021 sentence denotes The BRC repeats of BRCA2 are responsible for direct RAD51 interaction.
T619 951-954 DT denotes The
T620 959-966 NNS denotes repeats
T621 955-958 NN denotes BRC
T622 976-979 VBP denotes are
T623 967-969 IN denotes of
T624 970-975 NN denotes BRCA2
T625 980-991 JJ denotes responsible
T626 992-995 IN denotes for
T627 996-1002 JJ denotes direct
T628 1009-1020 NN denotes interaction
T629 1003-1008 NN denotes RAD51
T630 1020-1021 . denotes .
T631 1021-1240 sentence denotes Cells lacking BRCA1/2 fail to form damage-induced subnuclear RAD51 foci with normal efficiency, suggesting that these proteins are required for the formation of recombinase complexes at the sites of DNA damage [20,21].
T632 1022-1027 NNS denotes Cells
T633 1044-1048 VBP denotes fail
T634 1028-1035 VBG denotes lacking
T635 1036-1041 NN denotes BRCA1
T636 1042-1043 NN denotes 2
T637 1041-1042 HYPH denotes /
T638 1049-1051 TO denotes to
T639 1052-1056 VB denotes form
T640 1057-1063 NN denotes damage
T641 1064-1071 VBN denotes induced
T642 1063-1064 HYPH denotes -
T643 1083-1088 NN denotes RAD51
T644 1072-1082 JJ denotes subnuclear
T645 1089-1093 NNS denotes foci
T646 1094-1098 IN denotes with
T647 1099-1105 JJ denotes normal
T648 1106-1116 NN denotes efficiency
T649 1116-1118 , denotes ,
T650 1118-1128 VBG denotes suggesting
T651 1129-1133 IN denotes that
T652 1153-1161 VBN denotes required
T653 1134-1139 DT denotes these
T654 1140-1148 NN denotes proteins
T655 1149-1152 VBP denotes are
T656 1162-1165 IN denotes for
T657 1166-1169 DT denotes the
T658 1170-1179 NN denotes formation
T659 1180-1182 IN denotes of
T660 1183-1194 NN denotes recombinase
T661 1195-1204 NNS denotes complexes
T662 1205-1207 IN denotes at
T663 1208-1211 DT denotes the
T664 1212-1217 NNS denotes sites
T665 1218-1220 IN denotes of
T666 1221-1224 NN denotes DNA
T667 1225-1231 NN denotes damage
T668 1232-1233 -LRB- denotes [
T669 1236-1238 CD denotes 21
T670 1233-1235 CD denotes 20
T671 1235-1236 , denotes ,
T672 1238-1239 -RRB- denotes ]
T673 1239-1240 . denotes .
T674 1240-1401 sentence denotes Finally, genetic measurements of recombination frequency have shown that Brca1-/- embryonic stem (ES) cells are deficient in recombinational DSB repair [22,23].
T675 1241-1248 RB denotes Finally
T676 1303-1308 VBN denotes shown
T677 1248-1250 , denotes ,
T678 1250-1257 JJ denotes genetic
T679 1258-1270 NNS denotes measurements
T680 1271-1273 IN denotes of
T681 1274-1287 NN denotes recombination
T682 1288-1297 NN denotes frequency
T683 1298-1302 VBP denotes have
T684 1309-1313 IN denotes that
T685 1349-1352 VBP denotes are
T686 1314-1319 NN denotes Brca1
T687 1343-1348 NNS denotes cells
T688 1319-1320 SYM denotes -
T689 1320-1321 HYPH denotes /
T690 1321-1322 SYM denotes -
T691 1323-1332 JJ denotes embryonic
T692 1333-1337 NN denotes stem
T693 1338-1339 -LRB- denotes (
T694 1339-1341 NN denotes ES
T695 1341-1342 -RRB- denotes )
T696 1353-1362 JJ denotes deficient
T697 1363-1365 IN denotes in
T698 1366-1381 JJ denotes recombinational
T699 1386-1392 NN denotes repair
T700 1382-1385 NN denotes DSB
T701 1393-1394 -LRB- denotes [
T702 1397-1399 CD denotes 23
T703 1394-1396 CD denotes 22
T704 1396-1397 , denotes ,
T705 1399-1400 -RRB- denotes ]
T706 1400-1401 . denotes .
T707 1401-1696 sentence denotes The similarity between phenotypes associated with BRCA1 and BRCA2 deficiency, together with data showing a similar effect of DNA damage on distribution of BRCA1 and BRCA2 in repair-proficient cells, led to the hypothesis that BRCA2, like BRCA1, is required for efficient recombinational repair.
T708 1402-1405 DT denotes The
T709 1406-1416 NN denotes similarity
T710 1601-1604 VBD denotes led
T711 1417-1424 IN denotes between
T712 1425-1435 NNS denotes phenotypes
T713 1436-1446 VBN denotes associated
T714 1447-1451 IN denotes with
T715 1452-1457 NN denotes BRCA1
T716 1468-1478 NN denotes deficiency
T717 1458-1461 CC denotes and
T718 1462-1467 NN denotes BRCA2
T719 1478-1480 , denotes ,
T720 1480-1488 RB denotes together
T721 1489-1493 IN denotes with
T722 1494-1498 NNS denotes data
T723 1499-1506 VBG denotes showing
T724 1507-1508 DT denotes a
T725 1517-1523 NN denotes effect
T726 1509-1516 JJ denotes similar
T727 1524-1526 IN denotes of
T728 1527-1530 NN denotes DNA
T729 1531-1537 NN denotes damage
T730 1538-1540 IN denotes on
T731 1541-1553 NN denotes distribution
T732 1554-1556 IN denotes of
T733 1557-1562 NN denotes BRCA1
T734 1563-1566 CC denotes and
T735 1567-1572 NN denotes BRCA2
T736 1573-1575 IN denotes in
T737 1576-1582 NN denotes repair
T738 1583-1593 JJ denotes proficient
T739 1582-1583 HYPH denotes -
T740 1594-1599 NNS denotes cells
T741 1599-1601 , denotes ,
T742 1605-1607 IN denotes to
T743 1608-1611 DT denotes the
T744 1612-1622 NN denotes hypothesis
T745 1623-1627 IN denotes that
T746 1650-1658 VBN denotes required
T747 1628-1633 NN denotes BRCA2
T748 1633-1635 , denotes ,
T749 1635-1639 IN denotes like
T750 1640-1645 NN denotes BRCA1
T751 1645-1647 , denotes ,
T752 1647-1649 VBZ denotes is
T753 1659-1662 IN denotes for
T754 1663-1672 JJ denotes efficient
T755 1689-1695 NN denotes repair
T756 1673-1688 JJ denotes recombinational
T757 1695-1696 . denotes .
T758 1696-1777 sentence denotes The paper by Moynahan et al [24] provides important support for this hypothesis.
T759 1697-1700 DT denotes The
T760 1701-1706 NN denotes paper
T761 1730-1738 VBZ denotes provides
T762 1707-1709 IN denotes by
T763 1710-1718 NNP denotes Moynahan
T764 1719-1721 FW denotes et
T765 1722-1724 FW denotes al
T766 1725-1726 -LRB- denotes [
T767 1726-1728 CD denotes 24
T768 1728-1729 -RRB- denotes ]
T769 1739-1748 JJ denotes important
T770 1749-1756 NN denotes support
T771 1757-1760 IN denotes for
T772 1761-1765 DT denotes this
T773 1766-1776 NN denotes hypothesis
T774 1776-1777 . denotes .
R241 T437 T438 prep Following,provided
R242 T439 T440 det the,discovery
R243 T440 T437 pobj discovery,Following
R244 T441 T440 compound landmark,discovery
R245 T442 T440 prep by,discovery
R246 T443 T442 pobj Scully,by
R247 T444 T445 advmod et,al
R248 T445 T443 advmod al,Scully
R249 T446 T447 mark that,colocalizes
R250 T447 T440 acl colocalizes,discovery
R251 T448 T449 det the,RAD51
R252 T449 T447 nsubj RAD51,colocalizes
R253 T450 T449 amod homologous,RAD51
R254 T451 T449 compound recombinase,RAD51
R255 T452 T447 prep at,colocalizes
R256 T453 T454 amod subnuclear,sites
R257 T454 T452 pobj sites,at
R258 T455 T447 prep with,colocalizes
R259 T456 T455 pobj BRCA1,with
R260 T457 T458 punct [,9
R261 T458 T447 parataxis 9,colocalizes
R262 T459 T458 punct ],9
R263 T460 T438 punct ", ",provided
R264 T461 T462 det a,number
R265 T462 T438 nsubj number,provided
R266 T463 T462 prep of,number
R267 T464 T465 amod additional,results
R268 T465 T463 pobj results,of
R269 T466 T438 aux have,provided
R270 T467 T438 dobj evidence,provided
R271 T468 T469 mark that,involved
R272 T469 T467 acl involved,evidence
R273 T470 T471 preconj both,BRCA1
R274 T471 T469 nsubjpass BRCA1,involved
R275 T472 T471 cc and,BRCA1
R276 T473 T471 conj BRCA2,BRCA1
R277 T474 T469 auxpass are,involved
R278 T475 T469 prep in,involved
R279 T476 T477 amod recombinational,repair
R280 T477 T475 pobj repair,in
R281 T478 T477 prep of,repair
R282 T479 T480 compound DNA,damage
R283 T480 T478 pobj damage,of
R284 T481 T438 punct .,provided
R285 T483 T484 nsubj BRCA1,form
R286 T485 T483 cc and,BRCA1
R287 T486 T483 conj BRCA2,BRCA1
R288 T487 T488 amod discrete,foci
R289 T488 T484 dobj foci,form
R290 T489 T488 amod nuclear,foci
R291 T490 T484 prep during,form
R292 T491 T492 det the,phase
R293 T492 T490 pobj phase,during
R294 T493 T492 compound S,phase
R295 T494 T490 cc and,during
R296 T495 T490 conj after,during
R297 T496 T495 pobj exposure,after
R298 T497 T496 prep to,exposure
R299 T498 T499 npadvmod DNA,damaging
R300 T499 T500 amod damaging,agents
R301 T500 T497 pobj agents,to
R302 T501 T502 punct [,11
R303 T502 T484 parataxis 11,form
R304 T503 T502 nummod 9,11
R305 T504 T502 punct ",",11
R306 T505 T502 nummod 10,11
R307 T506 T502 punct ",",11
R308 T507 T502 punct ],11
R309 T508 T484 punct .,form
R310 T510 T511 det These,foci
R311 T511 T512 nsubj foci,are
R312 T513 T512 advmod probably,are
R313 T514 T512 attr sites,are
R314 T515 T514 prep of,sites
R315 T516 T515 pobj repair,of
R316 T517 T516 prep of,repair
R317 T518 T519 amod spontaneous,damage
R318 T519 T517 pobj damage,of
R319 T520 T518 cc and,spontaneous
R320 T521 T518 conj induced,spontaneous
R321 T522 T519 compound DNA,damage
R322 T523 T524 punct [,14
R323 T524 T512 parataxis 14,are
R324 T525 T524 nummod 12,14
R325 T526 T524 punct ",",14
R326 T527 T524 nummod 13,14
R327 T528 T524 punct ",",14
R328 T529 T524 punct ],14
R329 T530 T512 punct .,are
R330 T532 T533 compound Cell,lines
R331 T533 T534 nsubj lines,are
R332 T535 T533 amod defective,lines
R333 T536 T535 prep in,defective
R334 T537 T538 preconj either,BRCA1
R335 T538 T536 pobj BRCA1,in
R336 T539 T538 cc or,BRCA1
R337 T540 T538 conj BRCA2,BRCA1
R338 T541 T534 acomp sensitive,are
R339 T542 T541 prep to,sensitive
R340 T543 T544 amod damaging,agents
R341 T544 T542 pobj agents,to
R342 T545 T546 dep that,form
R343 T546 T544 relcl form,agents
R344 T547 T548 amod double,strand
R345 T548 T550 amod strand,breaks
R346 T549 T548 punct -,strand
R347 T550 T546 dobj breaks,form
R348 T551 T550 punct (,breaks
R349 T552 T550 appos DSBs,breaks
R350 T553 T534 punct ),are
R351 T554 T534 punct ", ",are
R352 T555 T556 mark as,are
R353 T556 T534 advcl are,are
R354 T557 T558 amod other,lines
R355 T558 T556 nsubj lines,are
R356 T559 T558 compound cell,lines
R357 T560 T558 amod defective,lines
R358 T561 T560 prep in,defective
R359 T562 T563 amod recombinational,repair
R360 T563 T561 pobj repair,in
R361 T564 T565 punct (,reviewed
R362 T565 T534 parataxis reviewed,are
R363 T566 T565 prep in,reviewed
R364 T567 T566 punct [,in
R365 T568 T566 pobj 15,in
R366 T569 T566 punct ],in
R367 T570 T565 punct ),reviewed
R368 T571 T534 punct .,are
R369 T573 T574 nsubj BRCA2,interacts
R370 T575 T574 prep with,interacts
R371 T576 T577 det the,recombinase
R372 T577 T575 pobj recombinase,with
R373 T578 T577 compound RAD51,recombinase
R374 T579 T574 prep via,interacts
R375 T580 T581 amod direct,contacts
R376 T581 T579 pobj contacts,via
R377 T582 T583 compound protein,protein
R378 T583 T581 compound protein,contacts
R379 T584 T583 punct -,protein
R380 T585 T586 punct [,19
R381 T586 T574 parataxis 19,interacts
R382 T587 T586 nummod 16,19
R383 T588 T586 punct ",",19
R384 T589 T586 nummod 17,19
R385 T590 T586 punct ",",19
R386 T591 T586 nummod 18,19
R387 T592 T586 punct ",",19
R388 T593 T586 punct ],19
R389 T594 T574 punct .,interacts
R390 T596 T597 amod Biochemical,analysis
R391 T597 T598 nsubj analysis,showed
R392 T599 T598 advmod also,showed
R393 T600 T598 dobj interaction,showed
R394 T601 T600 prep between,interaction
R395 T602 T601 pobj BRCA1,between
R396 T603 T602 cc and,BRCA1
R397 T604 T602 conj RAD51,BRCA1
R398 T605 T598 punct ", ",showed
R399 T606 T607 mark although,been
R400 T607 T598 advcl been,showed
R401 T608 T609 det these,interactions
R402 T609 T607 nsubj interactions,been
R403 T610 T609 amod detected,interactions
R404 T611 T607 aux may,been
R405 T612 T607 aux have,been
R406 T613 T607 acomp indirect,been
R407 T614 T615 punct [,9
R408 T615 T598 parataxis 9,showed
R409 T616 T615 punct ],9
R410 T617 T598 punct .,showed
R411 T619 T620 det The,repeats
R412 T620 T622 nsubj repeats,are
R413 T621 T620 compound BRC,repeats
R414 T623 T620 prep of,repeats
R415 T624 T623 pobj BRCA2,of
R416 T625 T622 acomp responsible,are
R417 T626 T625 prep for,responsible
R418 T627 T628 amod direct,interaction
R419 T628 T626 pobj interaction,for
R420 T629 T628 compound RAD51,interaction
R421 T630 T622 punct .,are
R422 T632 T633 nsubj Cells,fail
R423 T634 T632 acl lacking,Cells
R424 T635 T636 compound BRCA1,2
R425 T636 T634 dobj 2,lacking
R426 T637 T636 punct /,2
R427 T638 T639 aux to,form
R428 T639 T633 xcomp form,fail
R429 T640 T641 npadvmod damage,induced
R430 T641 T643 amod induced,RAD51
R431 T642 T641 punct -,induced
R432 T643 T645 compound RAD51,foci
R433 T644 T643 amod subnuclear,RAD51
R434 T645 T639 dobj foci,form
R435 T646 T639 prep with,form
R436 T647 T648 amod normal,efficiency
R437 T648 T646 pobj efficiency,with
R438 T649 T633 punct ", ",fail
R439 T650 T633 advcl suggesting,fail
R440 T651 T652 mark that,required
R441 T652 T650 ccomp required,suggesting
R442 T653 T654 det these,proteins
R443 T654 T652 nsubjpass proteins,required
R444 T655 T652 auxpass are,required
R445 T656 T652 prep for,required
R446 T657 T658 det the,formation
R447 T658 T656 pobj formation,for
R448 T659 T658 prep of,formation
R449 T660 T661 compound recombinase,complexes
R450 T661 T659 pobj complexes,of
R451 T662 T658 prep at,formation
R452 T663 T664 det the,sites
R453 T664 T662 pobj sites,at
R454 T665 T664 prep of,sites
R455 T666 T667 compound DNA,damage
R456 T667 T665 pobj damage,of
R457 T668 T669 punct [,21
R458 T669 T633 parataxis 21,fail
R459 T670 T669 nummod 20,21
R460 T671 T669 punct ",",21
R461 T672 T669 punct ],21
R462 T673 T633 punct .,fail
R463 T675 T676 advmod Finally,shown
R464 T677 T676 punct ", ",shown
R465 T678 T679 amod genetic,measurements
R466 T679 T676 nsubj measurements,shown
R467 T680 T679 prep of,measurements
R468 T681 T682 compound recombination,frequency
R469 T682 T680 pobj frequency,of
R470 T683 T676 aux have,shown
R471 T684 T685 mark that,are
R472 T685 T676 ccomp are,shown
R473 T686 T687 nmod Brca1,cells
R474 T687 T685 nsubj cells,are
R475 T688 T686 punct -,Brca1
R476 T689 T686 punct /,Brca1
R477 T690 T686 punct -,Brca1
R478 T691 T692 amod embryonic,stem
R479 T692 T687 nmod stem,cells
R480 T693 T692 punct (,stem
R481 T694 T692 appos ES,stem
R482 T695 T687 punct ),cells
R483 T696 T685 acomp deficient,are
R484 T697 T696 prep in,deficient
R485 T698 T699 amod recombinational,repair
R486 T699 T697 pobj repair,in
R487 T700 T699 compound DSB,repair
R488 T701 T702 punct [,23
R489 T702 T676 parataxis 23,shown
R490 T703 T702 nummod 22,23
R491 T704 T702 punct ",",23
R492 T705 T702 punct ],23
R493 T706 T676 punct .,shown
R494 T708 T709 det The,similarity
R495 T709 T710 nsubj similarity,led
R496 T711 T709 prep between,similarity
R497 T712 T711 pobj phenotypes,between
R498 T713 T712 acl associated,phenotypes
R499 T714 T713 prep with,associated
R500 T715 T716 nmod BRCA1,deficiency
R501 T716 T714 pobj deficiency,with
R502 T717 T715 cc and,BRCA1
R503 T718 T715 conj BRCA2,BRCA1
R504 T719 T709 punct ", ",similarity
R505 T720 T721 advmod together,with
R506 T721 T709 prep with,similarity
R507 T722 T721 pobj data,with
R508 T723 T722 acl showing,data
R509 T724 T725 det a,effect
R510 T725 T723 dobj effect,showing
R511 T726 T725 amod similar,effect
R512 T727 T725 prep of,effect
R513 T728 T729 compound DNA,damage
R514 T729 T727 pobj damage,of
R515 T730 T729 prep on,damage
R516 T731 T730 pobj distribution,on
R517 T732 T731 prep of,distribution
R518 T733 T732 pobj BRCA1,of
R519 T734 T733 cc and,BRCA1
R520 T735 T733 conj BRCA2,BRCA1
R521 T736 T731 prep in,distribution
R522 T737 T738 npadvmod repair,proficient
R523 T738 T740 amod proficient,cells
R524 T739 T738 punct -,proficient
R525 T740 T736 pobj cells,in
R526 T741 T710 punct ", ",led
R527 T742 T710 prep to,led
R528 T743 T744 det the,hypothesis
R529 T744 T742 pobj hypothesis,to
R530 T745 T746 mark that,required
R531 T746 T744 acl required,hypothesis
R532 T747 T746 nsubjpass BRCA2,required
R533 T748 T747 punct ", ",BRCA2
R534 T749 T747 prep like,BRCA2
R535 T750 T749 pobj BRCA1,like
R536 T751 T746 punct ", ",required
R537 T752 T746 auxpass is,required
R538 T753 T746 prep for,required
R539 T754 T755 amod efficient,repair
R540 T755 T753 pobj repair,for
R541 T756 T755 amod recombinational,repair
R542 T757 T710 punct .,led
R543 T759 T760 det The,paper
R544 T760 T761 nsubj paper,provides
R545 T762 T760 prep by,paper
R546 T763 T762 pobj Moynahan,by
R547 T764 T765 advmod et,al
R548 T765 T763 advmod al,Moynahan
R549 T766 T767 punct [,24
R550 T767 T760 parataxis 24,paper
R551 T768 T767 punct ],24
R552 T769 T770 amod important,support
R553 T770 T761 dobj support,provides
R554 T771 T761 dative for,provides
R555 T772 T773 det this,hypothesis
R556 T773 T771 pobj hypothesis,for
R557 T774 T761 punct .,provides