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PMC:1382200 / 4595-7068 JSONTXT

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Id Subject Object Predicate Lexical cue
T3849 0-8 VBN denotes Targeted
T3850 14-22 NN denotes deletion
T3851 9-13 NN denotes gene
T3852 31-39 VBZ denotes provides
T3853 23-25 IN denotes in
T3854 26-30 NNS denotes mice
T3855 40-41 DT denotes a
T3856 51-59 NN denotes approach
T3857 42-50 JJ denotes powerful
T3858 60-62 IN denotes to
T3859 63-74 VBG denotes determining
T3860 75-78 DT denotes the
T3861 93-98 NNS denotes roles
T3862 79-92 JJ denotes physiological
T3863 99-101 IN denotes of
T3864 102-103 NN denotes μ
T3865 111-118 NN denotes calpain
T3866 103-104 HYPH denotes -
T3867 105-108 CC denotes and
T3868 109-110 NN denotes m
T3869 110-111 HYPH denotes -
T3870 119-122 CC denotes and
T3871 123-126 DT denotes the
T3872 127-138 NN denotes opportunity
T3873 139-141 TO denotes to
T3874 142-150 VB denotes approach
T3875 151-156 PRP$ denotes their
T3876 174-183 NNS denotes functions
T3877 157-164 NN denotes isoform
T3878 165-173 JJ denotes specific
T3879 183-184 . denotes .
T3880 184-322 sentence denotes Initial studies targeted Capn4 based on the prediction that loss of this calpain subunit would abolish activity of both μ- and m-calpain.
T3881 185-192 JJ denotes Initial
T3882 193-200 NNS denotes studies
T3883 201-209 VBD denotes targeted
T3884 210-215 NN denotes Capn4
T3885 216-221 VBN denotes based
T3886 222-224 IN denotes on
T3887 225-228 DT denotes the
T3888 229-239 NN denotes prediction
T3889 240-244 IN denotes that
T3890 280-287 VB denotes abolish
T3891 245-249 NN denotes loss
T3892 250-252 IN denotes of
T3893 253-257 DT denotes this
T3894 266-273 NN denotes subunit
T3895 258-265 NN denotes calpain
T3896 274-279 MD denotes would
T3897 288-296 NN denotes activity
T3898 297-299 IN denotes of
T3899 300-304 CC denotes both
T3900 305-306 NN denotes μ
T3901 314-321 NN denotes calpain
T3902 306-307 HYPH denotes -
T3903 308-311 CC denotes and
T3904 312-313 NN denotes m
T3905 313-314 HYPH denotes -
T3906 321-322 . denotes .
T3907 322-475 sentence denotes Capn4-/- murine embryos died between days 10 and 11 of gestation, and there was no detectable μ- or m-calpain activity in these or younger embryos [31].
T3908 323-328 NN denotes Capn4
T3909 339-346 NNS denotes embryos
T3910 328-329 SYM denotes -
T3911 329-330 HYPH denotes /
T3912 330-331 SYM denotes -
T3913 332-338 JJ denotes murine
T3914 347-351 VBD denotes died
T3915 352-359 IN denotes between
T3916 360-364 NNS denotes days
T3917 365-367 CD denotes 10
T3918 368-371 CC denotes and
T3919 372-374 CD denotes 11
T3920 375-377 IN denotes of
T3921 378-387 NN denotes gestation
T3922 387-389 , denotes ,
T3923 389-392 CC denotes and
T3924 393-398 EX denotes there
T3925 399-402 VBD denotes was
T3926 403-405 DT denotes no
T3927 433-441 NN denotes activity
T3928 406-416 JJ denotes detectable
T3929 417-418 NN denotes μ
T3930 425-432 NN denotes calpain
T3931 418-419 HYPH denotes -
T3932 420-422 CC denotes or
T3933 423-424 NN denotes m
T3934 424-425 HYPH denotes -
T3935 442-444 IN denotes in
T3936 445-450 DT denotes these
T3937 451-453 CC denotes or
T3938 454-461 JJR denotes younger
T3939 462-469 NNS denotes embryos
T3940 470-471 -LRB- denotes [
T3941 471-473 CD denotes 31
T3942 473-474 -RRB- denotes ]
T3943 474-475 . denotes .
T3944 475-808 sentence denotes Capn4-/- murine embryonic fibroblasts (MEFs) could be cultured from these embryos, although they also lacked calpain activity as assessed by casein zymography or by the formation of characteristic spectrin breakdown products, and they displayed migration defects consistent with a role for calpain in release of focal adhesions [9].
T3945 476-481 NN denotes Capn4
T3946 530-538 VBN denotes cultured
T3947 481-482 SYM denotes -
T3948 482-483 HYPH denotes /
T3949 483-484 SYM denotes -
T3950 485-491 JJ denotes murine
T3951 502-513 NNS denotes fibroblasts
T3952 492-501 JJ denotes embryonic
T3953 514-515 -LRB- denotes (
T3954 515-519 NNS denotes MEFs
T3955 519-520 -RRB- denotes )
T3956 521-526 MD denotes could
T3957 527-529 VB denotes be
T3958 539-543 IN denotes from
T3959 544-549 DT denotes these
T3960 550-557 NNS denotes embryos
T3961 557-559 , denotes ,
T3962 559-567 IN denotes although
T3963 578-584 VBD denotes lacked
T3964 568-572 PRP denotes they
T3965 573-577 RB denotes also
T3966 585-592 NN denotes calpain
T3967 593-601 NN denotes activity
T3968 602-604 IN denotes as
T3969 605-613 VBN denotes assessed
T3970 614-616 IN denotes by
T3971 617-623 NN denotes casein
T3972 624-634 NN denotes zymography
T3973 635-637 CC denotes or
T3974 638-640 IN denotes by
T3975 641-644 DT denotes the
T3976 645-654 NN denotes formation
T3977 655-657 IN denotes of
T3978 658-672 JJ denotes characteristic
T3979 692-700 NNS denotes products
T3980 673-681 NN denotes spectrin
T3981 682-691 NN denotes breakdown
T3982 700-702 , denotes ,
T3983 702-705 CC denotes and
T3984 706-710 PRP denotes they
T3985 711-720 VBD denotes displayed
T3986 721-730 NN denotes migration
T3987 731-738 NNS denotes defects
T3988 739-749 JJ denotes consistent
T3989 750-754 IN denotes with
T3990 755-756 DT denotes a
T3991 757-761 NN denotes role
T3992 762-765 IN denotes for
T3993 766-773 NN denotes calpain
T3994 774-776 IN denotes in
T3995 777-784 NN denotes release
T3996 785-787 IN denotes of
T3997 788-793 JJ denotes focal
T3998 794-803 NNS denotes adhesions
T3999 804-805 -LRB- denotes [
T4000 805-806 CD denotes 9
T4001 806-807 -RRB- denotes ]
T4002 807-808 . denotes .
T4003 808-987 sentence denotes An independently derived Capn4 knockout, involving a more extensive deletion of the gene, resulted in an earlier embryonic lethality, apparently at a pre-implantation stage [32].
T4004 809-811 DT denotes An
T4005 840-848 NN denotes knockout
T4006 812-825 RB denotes independently
T4007 826-833 VBN denotes derived
T4008 834-839 NN denotes Capn4
T4009 899-907 VBD denotes resulted
T4010 848-850 , denotes ,
T4011 850-859 VBG denotes involving
T4012 860-861 DT denotes a
T4013 877-885 NN denotes deletion
T4014 862-866 RBR denotes more
T4015 867-876 JJ denotes extensive
T4016 886-888 IN denotes of
T4017 889-892 DT denotes the
T4018 893-897 NN denotes gene
T4019 897-899 , denotes ,
T4020 908-910 IN denotes in
T4021 911-913 DT denotes an
T4022 932-941 NN denotes lethality
T4023 914-921 JJR denotes earlier
T4024 922-931 JJ denotes embryonic
T4025 941-943 , denotes ,
T4026 943-953 RB denotes apparently
T4027 954-956 IN denotes at
T4028 957-958 DT denotes a
T4029 976-981 NN denotes stage
T4030 959-975 JJ denotes pre-implantation
T4031 982-983 -LRB- denotes [
T4032 983-985 CD denotes 32
T4033 985-986 -RRB- denotes ]
T4034 986-987 . denotes .
T4035 987-1304 sentence denotes The different times of embryonic lethality suggested that the first reported Capn4-/- mice [31] were targeted with a hypomorphic mutation, which retained some small level of calpain activity, allowing for their survival to mid-gestation, while the second reported Capn4-/- mice [32] represented a true null mutation.
T4036 988-991 DT denotes The
T4037 1002-1007 NNS denotes times
T4038 992-1001 JJ denotes different
T4039 1031-1040 VBD denotes suggested
T4040 1008-1010 IN denotes of
T4041 1011-1020 JJ denotes embryonic
T4042 1021-1030 NN denotes lethality
T4043 1041-1045 IN denotes that
T4044 1089-1097 VBN denotes targeted
T4045 1046-1049 DT denotes the
T4046 1074-1078 NNS denotes mice
T4047 1050-1055 JJ denotes first
T4048 1056-1064 VBN denotes reported
T4049 1065-1070 NN denotes Capn4
T4050 1070-1071 SYM denotes -
T4051 1071-1072 HYPH denotes /
T4052 1072-1073 SYM denotes -
T4053 1079-1080 -LRB- denotes [
T4054 1080-1082 CD denotes 31
T4055 1082-1083 -RRB- denotes ]
T4056 1084-1088 VBD denotes were
T4057 1098-1102 IN denotes with
T4058 1103-1104 DT denotes a
T4059 1117-1125 NN denotes mutation
T4060 1105-1116 JJ denotes hypomorphic
T4061 1125-1127 , denotes ,
T4062 1127-1132 WDT denotes which
T4063 1133-1141 VBD denotes retained
T4064 1142-1146 DT denotes some
T4065 1153-1158 NN denotes level
T4066 1147-1152 JJ denotes small
T4067 1159-1161 IN denotes of
T4068 1162-1169 NN denotes calpain
T4069 1170-1178 NN denotes activity
T4070 1178-1180 , denotes ,
T4071 1180-1188 VBG denotes allowing
T4072 1189-1192 IN denotes for
T4073 1193-1198 PRP$ denotes their
T4074 1199-1207 NN denotes survival
T4075 1208-1210 IN denotes to
T4076 1211-1224 NN denotes mid-gestation
T4077 1224-1226 , denotes ,
T4078 1226-1231 IN denotes while
T4079 1271-1282 VBD denotes represented
T4080 1232-1235 DT denotes the
T4081 1261-1265 NNS denotes mice
T4082 1236-1242 JJ denotes second
T4083 1243-1251 VBN denotes reported
T4084 1252-1257 NN denotes Capn4
T4085 1257-1258 SYM denotes -
T4086 1258-1259 HYPH denotes /
T4087 1259-1260 SYM denotes -
T4088 1266-1267 -LRB- denotes [
T4089 1267-1269 CD denotes 32
T4090 1269-1270 -RRB- denotes ]
T4091 1283-1284 DT denotes a
T4092 1295-1303 NN denotes mutation
T4093 1285-1289 JJ denotes true
T4094 1290-1294 JJ denotes null
T4095 1303-1304 . denotes .
T4096 1304-1538 sentence denotes Disruption of Capn1, encoding the μ-calpain catalytic subunit, was subsequently reported to result in fertile, viable mice with some mild defects in the μ-calpain rich platelets relating to their aggregation and clot retraction [33].
T4097 1305-1315 NN denotes Disruption
T4098 1385-1393 VBN denotes reported
T4099 1316-1318 IN denotes of
T4100 1319-1324 NN denotes Capn1
T4101 1324-1326 , denotes ,
T4102 1326-1334 VBG denotes encoding
T4103 1335-1338 DT denotes the
T4104 1359-1366 NN denotes subunit
T4105 1339-1340 NN denotes μ
T4106 1341-1348 NN denotes calpain
T4107 1340-1341 HYPH denotes -
T4108 1349-1358 JJ denotes catalytic
T4109 1366-1368 , denotes ,
T4110 1368-1371 VBD denotes was
T4111 1372-1384 RB denotes subsequently
T4112 1394-1396 TO denotes to
T4113 1397-1403 VB denotes result
T4114 1404-1406 IN denotes in
T4115 1407-1414 JJ denotes fertile
T4116 1423-1427 NNS denotes mice
T4117 1414-1416 , denotes ,
T4118 1416-1422 JJ denotes viable
T4119 1428-1432 IN denotes with
T4120 1433-1437 DT denotes some
T4121 1443-1450 NNS denotes defects
T4122 1438-1442 JJ denotes mild
T4123 1451-1453 IN denotes in
T4124 1454-1457 DT denotes the
T4125 1473-1482 NNS denotes platelets
T4126 1458-1459 NN denotes μ
T4127 1460-1467 NN denotes calpain
T4128 1459-1460 HYPH denotes -
T4129 1468-1472 JJ denotes rich
T4130 1483-1491 VBG denotes relating
T4131 1492-1494 IN denotes to
T4132 1495-1500 PRP$ denotes their
T4133 1501-1512 NN denotes aggregation
T4134 1513-1516 CC denotes and
T4135 1517-1521 NN denotes clot
T4136 1522-1532 NN denotes retraction
T4137 1533-1534 -LRB- denotes [
T4138 1534-1536 CD denotes 33
T4139 1536-1537 -RRB- denotes ]
T4140 1537-1538 . denotes .
T4141 1538-1686 sentence denotes The fact that Capn4 null mice die during embryogenesis indicates that at least one of the ubiquitous calpains is essential for development to term.
T4142 1539-1542 DT denotes The
T4143 1543-1547 NN denotes fact
T4144 1594-1603 VBZ denotes indicates
T4145 1548-1552 IN denotes that
T4146 1569-1572 VBP denotes die
T4147 1553-1558 NN denotes Capn4
T4148 1559-1563 JJ denotes null
T4149 1564-1568 NNS denotes mice
T4150 1573-1579 IN denotes during
T4151 1580-1593 NN denotes embryogenesis
T4152 1604-1608 IN denotes that
T4153 1649-1651 VBZ denotes is
T4154 1609-1611 RB denotes at
T4155 1618-1621 CD denotes one
T4156 1612-1617 RBS denotes least
T4157 1622-1624 IN denotes of
T4158 1625-1628 DT denotes the
T4159 1640-1648 NNS denotes calpains
T4160 1629-1639 JJ denotes ubiquitous
T4161 1652-1661 JJ denotes essential
T4162 1662-1665 IN denotes for
T4163 1666-1677 NN denotes development
T4164 1678-1680 IN denotes to
T4165 1681-1685 NN denotes term
T4166 1685-1686 . denotes .
T4167 1686-1949 sentence denotes The viability of Capn1-deficient mice does not however distinguish between two possibilities: either that m-calpain is specifically required during embryogenesis, or that either form of calpain alone is sufficient and can compensate for the absence of the other.
T4168 1687-1690 DT denotes The
T4169 1691-1700 NN denotes viability
T4170 1742-1753 VB denotes distinguish
T4171 1701-1703 IN denotes of
T4172 1704-1709 NN denotes Capn1
T4173 1710-1719 JJ denotes deficient
T4174 1709-1710 HYPH denotes -
T4175 1720-1724 NNS denotes mice
T4176 1725-1729 VBZ denotes does
T4177 1730-1733 RB denotes not
T4178 1734-1741 RB denotes however
T4179 1754-1761 IN denotes between
T4180 1762-1765 CD denotes two
T4181 1766-1779 NNS denotes possibilities
T4182 1779-1781 : denotes :
T4183 1781-1787 CC denotes either
T4184 1819-1827 VBN denotes required
T4185 1788-1792 IN denotes that
T4186 1793-1794 NN denotes m
T4187 1795-1802 NN denotes calpain
T4188 1794-1795 HYPH denotes -
T4189 1803-1805 VBZ denotes is
T4190 1806-1818 RB denotes specifically
T4191 1828-1834 IN denotes during
T4192 1835-1848 NN denotes embryogenesis
T4193 1848-1850 , denotes ,
T4194 1850-1852 CC denotes or
T4195 1853-1857 IN denotes that
T4196 1887-1889 VBZ denotes is
T4197 1858-1864 CC denotes either
T4198 1865-1869 NN denotes form
T4199 1870-1872 IN denotes of
T4200 1873-1880 NN denotes calpain
T4201 1881-1886 RB denotes alone
T4202 1890-1900 JJ denotes sufficient
T4203 1901-1904 CC denotes and
T4204 1905-1908 MD denotes can
T4205 1909-1919 VB denotes compensate
T4206 1920-1923 IN denotes for
T4207 1924-1927 DT denotes the
T4208 1928-1935 NN denotes absence
T4209 1936-1938 IN denotes of
T4210 1939-1942 DT denotes the
T4211 1943-1948 JJ denotes other
T4212 1948-1949 . denotes .
T4213 1949-2051 sentence denotes To resolve this question, we have now knocked out the Capn2 gene encoding the m-80 k subunit in mice.
T4214 1950-1952 TO denotes To
T4215 1953-1960 VB denotes resolve
T4216 1988-1995 VBN denotes knocked
T4217 1961-1965 DT denotes this
T4218 1966-1974 NN denotes question
T4219 1974-1976 , denotes ,
T4220 1976-1978 PRP denotes we
T4221 1979-1983 VBP denotes have
T4222 1984-1987 RB denotes now
T4223 1996-1999 RP denotes out
T4224 2000-2003 DT denotes the
T4225 2010-2014 NN denotes gene
T4226 2004-2009 NN denotes Capn2
T4227 2015-2023 VBG denotes encoding
T4228 2024-2027 DT denotes the
T4229 2035-2042 NN denotes subunit
T4230 2028-2029 NN denotes m
T4231 2033-2034 NN denotes k
T4232 2029-2030 HYPH denotes -
T4233 2030-2032 CD denotes 80
T4234 2043-2045 IN denotes in
T4235 2046-2050 NNS denotes mice
T4236 2050-2051 . denotes .
T4237 2051-2196 sentence denotes We report here that Capn2 null embryos died prior to the implantation stage, indicating that m-calpain is indispensable for early embryogenesis.
T4238 2052-2054 PRP denotes We
T4239 2055-2061 VBP denotes report
T4240 2062-2066 RB denotes here
T4241 2067-2071 IN denotes that
T4242 2091-2095 VBD denotes died
T4243 2072-2077 NN denotes Capn2
T4244 2078-2082 JJ denotes null
T4245 2083-2090 NNS denotes embryos
T4246 2096-2101 JJ denotes prior
T4247 2102-2104 IN denotes to
T4248 2105-2108 DT denotes the
T4249 2122-2127 NN denotes stage
T4250 2109-2121 NN denotes implantation
T4251 2127-2129 , denotes ,
T4252 2129-2139 VBG denotes indicating
T4253 2140-2144 IN denotes that
T4254 2155-2157 VBZ denotes is
T4255 2145-2146 NN denotes m
T4256 2147-2154 NN denotes calpain
T4257 2146-2147 HYPH denotes -
T4258 2158-2171 JJ denotes indispensable
T4259 2172-2175 IN denotes for
T4260 2176-2181 JJ denotes early
T4261 2182-2195 NN denotes embryogenesis
T4262 2195-2196 . denotes .
T4263 2196-2350 sentence denotes This role cannot be fulfilled by μ-calpain, which is expressed in embryonic stem (ES) cells [31] and is assumed to be present at this stage of gestation.
T4264 2197-2201 DT denotes This
T4265 2202-2206 NN denotes role
T4266 2217-2226 VBN denotes fulfilled
T4267 2207-2210 MD denotes can
T4268 2210-2213 RB denotes not
T4269 2214-2216 VB denotes be
T4270 2227-2229 IN denotes by
T4271 2230-2231 NN denotes μ
T4272 2232-2239 NN denotes calpain
T4273 2231-2232 HYPH denotes -
T4274 2239-2241 , denotes ,
T4275 2241-2246 WDT denotes which
T4276 2250-2259 VBN denotes expressed
T4277 2247-2249 VBZ denotes is
T4278 2260-2262 IN denotes in
T4279 2263-2272 JJ denotes embryonic
T4280 2273-2277 NN denotes stem
T4281 2283-2288 NNS denotes cells
T4282 2278-2279 -LRB- denotes (
T4283 2279-2281 NN denotes ES
T4284 2281-2282 -RRB- denotes )
T4285 2289-2290 -LRB- denotes [
T4286 2290-2292 CD denotes 31
T4287 2292-2293 -RRB- denotes ]
T4288 2294-2297 CC denotes and
T4289 2298-2300 VBZ denotes is
T4290 2301-2308 VBN denotes assumed
T4291 2309-2311 TO denotes to
T4292 2312-2314 VB denotes be
T4293 2315-2322 JJ denotes present
T4294 2323-2325 IN denotes at
T4295 2326-2330 DT denotes this
T4296 2331-2336 NN denotes stage
T4297 2337-2339 IN denotes of
T4298 2340-2349 NN denotes gestation
T4299 2349-2350 . denotes .
T4300 2350-2473 sentence denotes This demonstrates unequivocally that m-calpain and μ-calpain have distinct physiological roles during early embryogenesis.
T4301 2351-2355 DT denotes This
T4302 2356-2368 VBZ denotes demonstrates
T4303 2369-2382 RB denotes unequivocally
T4304 2383-2387 IN denotes that
T4305 2412-2416 VBP denotes have
T4306 2388-2389 NN denotes m
T4307 2390-2397 NN denotes calpain
T4308 2389-2390 HYPH denotes -
T4309 2398-2401 CC denotes and
T4310 2402-2403 NN denotes μ
T4311 2404-2411 NN denotes calpain
T4312 2403-2404 HYPH denotes -
T4313 2417-2425 JJ denotes distinct
T4314 2440-2445 NNS denotes roles
T4315 2426-2439 JJ denotes physiological
T4316 2446-2452 IN denotes during
T4317 2453-2458 JJ denotes early
T4318 2459-2472 NN denotes embryogenesis
T4319 2472-2473 . denotes .
R804 T3849 T3850 amod Targeted,deletion
R807 T3850 T3852 nsubj deletion,provides
R809 T3851 T3850 compound gene,deletion
R810 T3853 T3850 prep in,deletion
R812 T3854 T3853 pobj mice,in
R813 T3855 T3856 det a,approach
R815 T3856 T3852 dobj approach,provides
R817 T3857 T3856 amod powerful,approach
R818 T3858 T3856 prep to,approach
R819 T3859 T3858 pcomp determining,to
R820 T3860 T3861 det the,roles
R822 T3861 T3859 dobj roles,determining
R823 T3862 T3861 amod physiological,roles
R824 T3863 T3861 prep of,roles
R826 T3864 T3865 nmod μ,calpain
R827 T3865 T3863 pobj calpain,of
R829 T3866 T3864 punct -,μ
R830 T3867 T3864 cc and,μ
R831 T3868 T3864 conj m,μ
R833 T3869 T3865 punct -,calpain
R834 T3870 T3856 cc and,approach
R835 T3871 T3872 det the,opportunity
R837 T3872 T3856 conj opportunity,approach
R838 T3873 T3874 aux to,approach
R840 T3874 T3872 acl approach,opportunity
R841 T3875 T3876 poss their,functions
R842 T3876 T3874 dobj functions,approach
R843 T3877 T3878 npadvmod isoform,specific
R844 T3878 T3876 amod specific,functions
R845 T3879 T3852 punct .,provides
R847 T3881 T3882 amod Initial,studies
R848 T3882 T3883 nsubj studies,targeted
R850 T3884 T3883 dobj Capn4,targeted
R851 T3885 T3883 prep based,targeted
R853 T3886 T3885 prep on,based
R854 T3887 T3888 det the,prediction
R855 T3888 T3886 pobj prediction,on
R856 T3889 T3890 mark that,abolish
R858 T3890 T3888 acl abolish,prediction
R860 T3891 T3890 nsubj loss,abolish
R861 T3892 T3891 prep of,loss
R862 T3893 T3894 det this,subunit
R863 T3894 T3892 pobj subunit,of
R865 T3895 T3894 compound calpain,subunit
R866 T3896 T3890 aux would,abolish
R868 T3897 T3890 dobj activity,abolish
R870 T3898 T3897 prep of,activity
R871 T3899 T3900 preconj both,μ
R873 T3900 T3901 nmod μ,calpain
R874 T3901 T3898 pobj calpain,of
R876 T3902 T3900 punct -,μ
R877 T3903 T3900 cc and,μ
R878 T3904 T3900 conj m,μ
R880 T3905 T3901 punct -,calpain
R881 T3906 T3883 punct .,targeted
R882 T3908 T3909 nmod Capn4,embryos
R884 T3909 T3914 nsubj embryos,died
R885 T3910 T3908 punct -,Capn4
R886 T3911 T3908 punct /,Capn4
R888 T3912 T3908 punct -,Capn4
R889 T3913 T3909 amod murine,embryos
R891 T3915 T3914 prep between,died
R892 T3916 T3917 nmod days,10
R894 T3917 T3915 pobj 10,between
R895 T3918 T3917 cc and,10
R896 T3919 T3917 conj 11,10
R897 T3920 T3917 prep of,10
R898 T3921 T3920 pobj gestation,of
R899 T3922 T3914 punct ", ",died
R901 T3923 T3914 cc and,died
R902 T3924 T3925 expl there,was
R903 T3925 T3914 conj was,died
R905 T3926 T3927 det no,activity
R906 T3927 T3925 attr activity,was
R907 T3928 T3927 amod detectable,activity
R909 T3929 T3930 nmod μ,calpain
R910 T3930 T3927 compound calpain,activity
R911 T3931 T3929 punct -,μ
R913 T3932 T3929 cc or,μ
R914 T3933 T3929 conj m,μ
R916 T3934 T3930 punct -,calpain
R917 T3935 T3925 prep in,was
R918 T3936 T3935 pobj these,in
R919 T3937 T3936 cc or,these
R921 T3938 T3939 amod younger,embryos
R922 T3939 T3936 conj embryos,these
R924 T3940 T3941 punct [,31
R925 T3941 T3925 parataxis 31,was
R926 T3942 T3941 punct ],31
R928 T3943 T3925 punct .,was
R929 T3945 T3946 nsubjpass Capn4,cultured
R931 T3947 T3945 punct -,Capn4
R932 T3948 T3945 punct /,Capn4
R934 T3949 T3945 punct -,Capn4
R935 T3950 T3951 amod murine,fibroblasts
R938 T3951 T3945 appos fibroblasts,Capn4
R940 T3952 T3951 amod embryonic,fibroblasts
R942 T3953 T3951 punct (,fibroblasts
R943 T3954 T3951 appos MEFs,fibroblasts
R946 T3955 T3946 punct ),cultured
R948 T3956 T3946 aux could,cultured
R949 T3957 T3946 auxpass be,cultured
R950 T3958 T3946 prep from,cultured
R951 T3959 T3960 det these,embryos
R952 T3960 T3958 pobj embryos,from
R953 T3961 T3946 punct ", ",cultured
R954 T3962 T3963 mark although,lacked
R956 T3963 T3946 advcl lacked,cultured
R957 T3964 T3963 nsubj they,lacked
R958 T3965 T3963 advmod also,lacked
R960 T3966 T3967 compound calpain,activity
R961 T3967 T3963 dobj activity,lacked
R962 T3968 T3969 mark as,assessed
R963 T3969 T3963 advcl assessed,lacked
R965 T3970 T3969 prep by,assessed
R966 T3971 T3972 compound casein,zymography
R967 T3972 T3970 pobj zymography,by
R969 T3973 T3970 cc or,by
R970 T3974 T3970 conj by,by
R972 T3975 T3976 det the,formation
R973 T3976 T3974 pobj formation,by
R975 T3977 T3976 prep of,formation
R976 T3978 T3979 amod characteristic,products
R977 T3979 T3977 pobj products,of
R979 T3980 T3981 compound spectrin,breakdown
R980 T3981 T3979 compound breakdown,products
R983 T3982 T3963 punct ", ",lacked
R984 T3983 T3963 cc and,lacked
R986 T3984 T3985 nsubj they,displayed
R987 T3985 T3963 conj displayed,lacked
R988 T3986 T3987 compound migration,defects
R990 T3987 T3985 dobj defects,displayed
R991 T3988 T3987 amod consistent,defects
R992 T3989 T3988 prep with,consistent
R994 T3990 T3991 det a,role
R995 T3991 T3989 pobj role,with
R997 T3992 T3991 prep for,role
R998 T3993 T3992 pobj calpain,for
R999 T3994 T3991 prep in,role
R1000 T3995 T3994 pobj release,in
R1001 T3996 T3995 prep of,release
R1002 T3997 T3998 amod focal,adhesions
R1003 T4061 T4059 punct ", ",mutation
R1004 T3998 T3996 pobj adhesions,of
R1005 T3999 T4000 punct [,9
R1006 T4000 T3985 parataxis 9,displayed
R1007 T4001 T4000 punct ],9
R1008 T4002 T3946 punct .,cultured
R1009 T4062 T4063 dep which,retained
R1010 T4004 T4005 det An,knockout
R1011 T4005 T4009 nsubj knockout,resulted
R1012 T4063 T4059 relcl retained,mutation
R1013 T4006 T4007 advmod independently,derived
R1014 T4007 T4005 amod derived,knockout
R1015 T4008 T4005 compound Capn4,knockout
R1016 T4064 T4065 det some,level
R1017 T4010 T4005 punct ", ",knockout
R1018 T4011 T4005 prep involving,knockout
R1019 T4065 T4063 dobj level,retained
R1020 T4012 T4013 det a,deletion
R1021 T4013 T4011 pobj deletion,involving
R1022 T4014 T4015 advmod more,extensive
R1023 T4066 T4065 amod small,level
R1024 T4015 T4013 amod extensive,deletion
R1025 T4016 T4013 prep of,deletion
R1026 T4067 T4065 prep of,level
R1027 T4017 T4018 det the,gene
R1028 T4018 T4016 pobj gene,of
R1029 T4019 T4009 punct ", ",resulted
R1030 T4020 T4009 prep in,resulted
R1031 T4068 T4069 compound calpain,activity
R1032 T4021 T4022 det an,lethality
R1033 T4022 T4020 pobj lethality,in
R1034 T4069 T4067 pobj activity,of
R1035 T4023 T4022 amod earlier,lethality
R1036 T4024 T4022 amod embryonic,lethality
R1037 T4025 T4009 punct ", ",resulted
R1038 T4070 T4044 punct ", ",targeted
R1039 T4026 T4027 advmod apparently,at
R1040 T4027 T4009 prep at,resulted
R1041 T4028 T4029 det a,stage
R1042 T4029 T4027 pobj stage,at
R1043 T4071 T4044 advcl allowing,targeted
R1044 T4030 T4029 amod pre-implantation,stage
R1045 T4031 T4032 punct [,32
R1046 T4032 T4009 parataxis 32,resulted
R1047 T4072 T4071 prep for,allowing
R1048 T4033 T4032 punct ],32
R1049 T4034 T4009 punct .,resulted
R1050 T4073 T4074 poss their,survival
R1051 T4036 T4037 det The,times
R1052 T4037 T4039 nsubj times,suggested
R1053 T4038 T4037 amod different,times
R1054 T4040 T4037 prep of,times
R1055 T4074 T4072 pobj survival,for
R1056 T4041 T4042 amod embryonic,lethality
R1057 T4042 T4040 pobj lethality,of
R1058 T4043 T4044 mark that,targeted
R1060 T4044 T4039 ccomp targeted,suggested
R1061 T4045 T4046 det the,mice
R1062 T4046 T4044 nsubjpass mice,targeted
R1063 T4076 T4075 pobj mid-gestation,to
R1064 T4047 T4046 amod first,mice
R1065 T4048 T4046 amod reported,mice
R1066 T4077 T4044 punct ", ",targeted
R1067 T4078 T4079 mark while,represented
R1068 T4079 T4044 advcl represented,targeted
R1069 T4080 T4081 det the,mice
R1071 T4082 T4081 amod second,mice
R1072 T4083 T4081 amod reported,mice
R1073 T4084 T4081 nmod Capn4,mice
R1074 T4085 T4084 punct -,Capn4
R1075 T4086 T4084 punct /,Capn4
R1076 T4087 T4084 punct -,Capn4
R1077 T4088 T4089 punct [,32
R1078 T4049 T4046 nmod Capn4,mice
R1079 T4089 T4081 parataxis 32,mice
R1080 T4090 T4089 punct ],32
R1081 T4050 T4049 punct -,Capn4
R1082 T4091 T4092 det a,mutation
R1083 T4051 T4049 punct /,Capn4
R1084 T4052 T4049 punct -,Capn4
R1085 T4092 T4079 dobj mutation,represented
R1086 T4053 T4054 punct [,31
R1087 T4054 T4046 parataxis 31,mice
R1088 T4093 T4092 amod true,mutation
R1089 T4055 T4054 punct ],31
R1090 T4094 T4092 amod null,mutation
R1091 T4056 T4044 auxpass were,targeted
R1092 T4057 T4044 prep with,targeted
R1093 T4058 T4059 det a,mutation
R1094 T4095 T4039 punct .,suggested
R1095 T4059 T4057 pobj mutation,with
R1096 T4060 T4059 amod hypomorphic,mutation
R1097 T4097 T4098 nsubjpass Disruption,reported
R1098 T4099 T4097 prep of,Disruption
R1099 T4100 T4099 pobj Capn1,of
R1100 T4101 T4097 punct ", ",Disruption
R1101 T4102 T4097 acl encoding,Disruption
R1102 T4168 T4169 det The,viability
R1103 T4169 T4170 nsubj viability,distinguish
R1104 T4171 T4169 prep of,viability
R1105 T4172 T4173 npadvmod Capn1,deficient
R1106 T4173 T4175 amod deficient,mice
R1107 T4174 T4173 punct -,deficient
R1108 T4103 T4104 det the,subunit
R1109 T4175 T4171 pobj mice,of
R1110 T4176 T4170 aux does,distinguish
R1111 T4177 T4170 neg not,distinguish
R1112 T4104 T4102 dobj subunit,encoding
R1113 T4178 T4170 advmod however,distinguish
R1114 T4179 T4170 prep between,distinguish
R1115 T4180 T4181 nummod two,possibilities
R1116 T4105 T4106 nmod μ,calpain
R1117 T4181 T4179 pobj possibilities,between
R1118 T4182 T4181 punct : ,possibilities
R1119 T4106 T4104 nmod calpain,subunit
R1120 T4183 T4184 preconj either,required
R1121 T4184 T4181 advcl required,possibilities
R1122 T4185 T4184 mark that,required
R1123 T4107 T4106 punct -,calpain
R1124 T4186 T4187 compound m,calpain
R1125 T4187 T4184 nsubjpass calpain,required
R1126 T4188 T4187 punct -,calpain
R1127 T4108 T4104 amod catalytic,subunit
R1128 T4189 T4184 auxpass is,required
R1129 T4190 T4184 advmod specifically,required
R1130 T4109 T4098 punct ", ",reported
R1131 T4191 T4184 prep during,required
R1132 T4192 T4191 pobj embryogenesis,during
R1133 T4193 T4184 punct ", ",required
R1134 T4110 T4098 auxpass was,reported
R1135 T4194 T4184 cc or,required
R1136 T4195 T4196 mark that,is
R1137 T4196 T4184 conj is,required
R1138 T4111 T4098 advmod subsequently,reported
R1139 T4197 T4198 preconj either,form
R1140 T4198 T4196 nsubj form,is
R1141 T4199 T4198 prep of,form
R1142 T4112 T4113 aux to,result
R1143 T4200 T4199 pobj calpain,of
R1144 T4201 T4198 advmod alone,form
R1145 T4202 T4196 acomp sufficient,is
R1146 T4113 T4098 xcomp result,reported
R1147 T4203 T4196 cc and,is
R1148 T4204 T4205 aux can,compensate
R1149 T4114 T4113 prep in,result
R1150 T4205 T4196 conj compensate,is
R1151 T4206 T4205 prep for,compensate
R1152 T4207 T4208 det the,absence
R1153 T4115 T4116 amod fertile,mice
R1154 T4208 T4206 pobj absence,for
R1155 T4209 T4208 prep of,absence
R1156 T4210 T4211 det the,other
R1157 T4211 T4209 pobj other,of
R1158 T4212 T4170 punct .,distinguish
R1159 T4116 T4114 pobj mice,in
R1160 T4214 T4215 aux To,resolve
R1161 T4215 T4216 advcl resolve,knocked
R1162 T4117 T4116 punct ", ",mice
R1163 T4217 T4218 det this,question
R1164 T4218 T4215 dobj question,resolve
R1165 T4118 T4116 amod viable,mice
R1166 T4219 T4216 punct ", ",knocked
R1167 T4220 T4216 nsubj we,knocked
R1168 T4221 T4216 aux have,knocked
R1169 T4119 T4116 prep with,mice
R1170 T4222 T4216 advmod now,knocked
R1171 T4223 T4216 prt out,knocked
R1172 T4224 T4225 det the,gene
R1173 T4120 T4121 det some,defects
R1174 T4225 T4216 dobj gene,knocked
R1175 T4226 T4225 compound Capn2,gene
R1176 T4227 T4225 acl encoding,gene
R1177 T4121 T4119 pobj defects,with
R1178 T4228 T4229 det the,subunit
R1179 T4229 T4227 dobj subunit,encoding
R1180 T4230 T4231 nmod m,k
R1181 T4122 T4121 amod mild,defects
R1182 T4231 T4229 compound k,subunit
R1183 T4232 T4231 punct -,k
R1184 T4233 T4231 nummod 80,k
R1185 T4123 T4121 prep in,defects
R1186 T4234 T4227 prep in,encoding
R1187 T4124 T4125 det the,platelets
R1188 T4125 T4123 pobj platelets,in
R1189 T4126 T4127 compound μ,calpain
R1190 T4235 T4234 pobj mice,in
R1191 T4236 T4216 punct .,knocked
R1192 T4127 T4129 npadvmod calpain,rich
R1193 T4238 T4239 nsubj We,report
R1194 T4128 T4127 punct -,calpain
R1195 T4240 T4239 advmod here,report
R1196 T4241 T4242 mark that,died
R1197 T4242 T4239 ccomp died,report
R1198 T4129 T4125 amod rich,platelets
R1199 T4243 T4244 npadvmod Capn2,null
R1200 T4244 T4245 amod null,embryos
R1201 T4130 T4121 acl relating,defects
R1202 T4245 T4242 nsubj embryos,died
R1203 T4246 T4247 amod prior,to
R1204 T4131 T4130 prep to,relating
R1205 T4247 T4242 prep to,died
R1206 T4248 T4249 det the,stage
R1207 T4249 T4247 pobj stage,to
R1208 T4250 T4249 compound implantation,stage
R1209 T4251 T4242 punct ", ",died
R1210 T4252 T4242 advcl indicating,died
R1211 T4132 T4133 poss their,aggregation
R1212 T4253 T4254 mark that,is
R1213 T4254 T4252 ccomp is,indicating
R1214 T4255 T4256 compound m,calpain
R1215 T4133 T4131 pobj aggregation,to
R1216 T4256 T4254 nsubj calpain,is
R1217 T4257 T4256 punct -,calpain
R1218 T4258 T4254 acomp indispensable,is
R1219 T4134 T4133 cc and,aggregation
R1220 T4259 T4258 prep for,indispensable
R1221 T4260 T4261 amod early,embryogenesis
R1222 T4261 T4259 pobj embryogenesis,for
R1223 T4135 T4136 compound clot,retraction
R1224 T4262 T4239 punct .,report
R1225 T4264 T4265 det This,role
R1226 T4136 T4133 conj retraction,aggregation
R1227 T4265 T4266 nsubjpass role,fulfilled
R1228 T4267 T4266 aux can,fulfilled
R1229 T4137 T4138 punct [,33
R1230 T4268 T4266 neg not,fulfilled
R1231 T4269 T4266 auxpass be,fulfilled
R1232 T4270 T4266 agent by,fulfilled
R1233 T4138 T4098 parataxis 33,reported
R1234 T4271 T4272 compound μ,calpain
R1235 T4272 T4270 pobj calpain,by
R1236 T4139 T4138 punct ],33
R1237 T4140 T4098 punct .,reported
R1238 T4142 T4143 det The,fact
R1239 T4273 T4272 punct -,calpain
R1240 T4274 T4272 punct ", ",calpain
R1241 T4275 T4276 dep which,expressed
R1242 T4143 T4144 nsubj fact,indicates
R1243 T4276 T4272 relcl expressed,calpain
R1244 T4277 T4276 auxpass is,expressed
R1245 T4278 T4276 prep in,expressed
R1246 T4145 T4146 mark that,die
R1247 T4279 T4280 amod embryonic,stem
R1248 T4280 T4281 nmod stem,cells
R1249 T4281 T4278 pobj cells,in
R1250 T4282 T4280 punct (,stem
R1251 T4146 T4143 acl die,fact
R1252 T4283 T4280 appos ES,stem
R1253 T4284 T4281 punct ),cells
R1254 T4285 T4286 punct [,31
R1255 T4147 T4148 npadvmod Capn4,null
R1256 T4286 T4276 parataxis 31,expressed
R1257 T4287 T4286 punct ],31
R1258 T4288 T4276 cc and,expressed
R1259 T4148 T4149 amod null,mice
R1260 T4289 T4290 auxpass is,assumed
R1261 T4290 T4276 conj assumed,expressed
R1262 T4291 T4292 aux to,be
R1263 T4292 T4290 xcomp be,assumed
R1264 T4293 T4292 acomp present,be
R1265 T4294 T4293 prep at,present
R1266 T4149 T4146 nsubj mice,die
R1270 T4150 T4146 prep during,die
R1271 T4298 T4297 pobj gestation,of
R1272 T4299 T4266 punct .,fulfilled
R1273 T4151 T4150 pobj embryogenesis,during
R1274 T4301 T4302 nsubj This,demonstrates
R1275 T4152 T4153 mark that,is
R1276 T4303 T4302 advmod unequivocally,demonstrates
R1277 T4304 T4305 mark that,have
R1278 T4305 T4302 ccomp have,demonstrates
R1279 T4153 T4144 ccomp is,indicates
R1280 T4306 T4307 compound m,calpain
R1281 T4307 T4305 nsubj calpain,have
R1282 T4308 T4307 punct -,calpain
R1283 T4154 T4155 advmod at,one
R1284 T4309 T4307 cc and,calpain
R1285 T4310 T4311 compound μ,calpain
R1286 T4311 T4307 conj calpain,calpain
R1287 T4155 T4153 nsubj one,is
R1288 T4312 T4311 punct -,calpain
R1289 T4313 T4314 amod distinct,roles
R1290 T4314 T4305 dobj roles,have
R1291 T4156 T4155 advmod least,one
R1292 T4315 T4314 amod physiological,roles
R1293 T4316 T4305 prep during,have
R1294 T4317 T4318 amod early,embryogenesis
R1295 T4157 T4155 prep of,one
R1296 T4318 T4316 pobj embryogenesis,during
R1297 T4319 T4302 punct .,demonstrates
R1298 T4158 T4159 det the,calpains
R1299 T4159 T4157 pobj calpains,of
R1300 T4160 T4159 amod ubiquitous,calpains
R1301 T4161 T4153 acomp essential,is
R1302 T4162 T4161 prep for,essential
R1303 T4163 T4162 pobj development,for
R1304 T4164 T4163 prep to,development
R1305 T4165 T4164 pobj term,to
R1306 T4166 T4144 punct .,indicates
R1059 T4075 T4074 prep to,survival
R1070 T4081 T4079 nsubj mice,represented
R1267 T4295 T4296 det this,stage
R1268 T4296 T4294 pobj stage,at
R1269 T4297 T4296 prep of,stage

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2984 9-13 SO:0000704 denotes gene
T2985 26-30 NCBITaxon:10088 denotes mice
T2986 157-164 SO:0001060 denotes isoform
T2987 210-215 PR:000005022 denotes Capn4
T2988 323-328 PR:000005022 denotes Capn4
T2989 332-338 NCBITaxon:39107 denotes murine
T2990 339-346 UBERON:0000922 denotes embryos
T2991 347-351 GO:0016265 denotes died
T2992 378-387 GO:0007565 denotes gestation
T2993 462-469 UBERON:0000922 denotes embryos
T2994 476-481 PR:000005022 denotes Capn4
T2995 485-491 NCBITaxon:39107 denotes murine
T2996 492-501 UBERON:0000922 denotes embryonic
T2997 502-513 CL:0000057 denotes fibroblasts
T2998 550-557 UBERON:0000922 denotes embryos
T2999 788-803 GO:0005925 denotes focal adhesions
T3000 834-839 PR:000005022 denotes Capn4
T3001 893-897 SO:0000704 denotes gene
T3002 922-931 UBERON:0000922 denotes embryonic
T3003 963-975 GO:0007566 denotes implantation
T3004 1011-1020 UBERON:0000922 denotes embryonic
T3005 1065-1070 PR:000005022 denotes Capn4
T3006 1074-1078 NCBITaxon:10088 denotes mice
T3007 1215-1224 GO:0007565 denotes gestation
T3008 1252-1257 PR:000005022 denotes Capn4
T3009 1261-1265 NCBITaxon:10088 denotes mice
T3010 1319-1324 PR:000005009 denotes Capn1
T3011 1339-1366 PR:000005009 denotes μ-calpain catalytic subunit
T3012 1423-1427 NCBITaxon:10088 denotes mice
T3013 1473-1482 CL:0000233 denotes platelets
T3014 1553-1558 PR:000005022 denotes Capn4
T3015 1564-1568 NCBITaxon:10088 denotes mice
T3016 1569-1572 GO:0016265 denotes die
T3017 1580-1593 GO:0009790 denotes embryogenesis
T3018 1704-1709 PR:000005009 denotes Capn1
T3019 1720-1724 NCBITaxon:10088 denotes mice
T3020 1835-1848 GO:0009790 denotes embryogenesis
T3021 2004-2009 PR:000005015 denotes Capn2
T3022 2010-2014 SO:0000704 denotes gene
T3023 2028-2042 PR:000005015 denotes m-80 k subunit
T3024 2046-2050 NCBITaxon:10088 denotes mice
T3025 2072-2077 PR:000005015 denotes Capn2
T3026 2083-2090 UBERON:0000922 denotes embryos
T3027 2091-2095 GO:0016265 denotes died
T3028 2109-2121 GO:0007566 denotes implantation
T3029 2182-2195 GO:0009790 denotes embryogenesis
T3030 2250-2259 GO:0010467 denotes expressed
T3031 2263-2272 UBERON:0000922 denotes embryonic
T3032 2263-2277 _FRAGMENT denotes embryonic stem
T3033 2283-2288 CL:0002322 denotes cells
T3034 2279-2281 _FRAGMENT denotes ES
T3035 2340-2349 GO:0007565 denotes gestation
T3036 2459-2472 GO:0009790 denotes embryogenesis
R273 T3033 T3032 _lexicallyChainedTo cells,embryonic stem
R276 T3033 T3034 _lexicallyChainedTo cells,ES

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3148 9-13 SO_EXT:0000704 denotes gene
T3149 14-22 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3150 26-30 NCBITaxon:10088 denotes mice
T3151 79-92 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T3152 102-104 _FRAGMENT denotes μ-
T3153 111-118 GO_PR_EXT:calpain_1_complex denotes calpain
T3154 109-118 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3155 157-164 SO_EXT:0001060 denotes isoform
T3156 210-215 PR_EXT:000005022 denotes Capn4
T3157 305-307 _FRAGMENT denotes μ-
T3158 314-321 GO_PR_EXT:calpain_1_complex denotes calpain
T3159 312-321 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3160 323-328 PR_EXT:000005022 denotes Capn4
T3161 328-329 SO_EXT:sequence_nullness_or_absence denotes -
T3162 330-331 SO_EXT:sequence_nullness_or_absence denotes -
T3163 332-338 NCBITaxon:39107 denotes murine
T3164 339-346 UBERON:0000922 denotes embryos
T3165 347-351 GO:0016265 denotes died
T3166 378-387 GO:0007565 denotes gestation
T3167 417-419 _FRAGMENT denotes μ-
T3168 425-432 GO_PR_EXT:calpain_1_complex denotes calpain
T3169 423-432 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3170 462-469 UBERON:0000922 denotes embryos
T3171 476-481 PR_EXT:000005022 denotes Capn4
T3172 481-482 SO_EXT:sequence_nullness_or_absence denotes -
T3173 483-484 SO_EXT:sequence_nullness_or_absence denotes -
T3174 485-491 NCBITaxon:39107 denotes murine
T3175 492-501 UBERON:0000922 denotes embryonic
T3176 502-513 CL:0000057 denotes fibroblasts
T3177 550-557 UBERON:0000922 denotes embryos
T3178 673-681 GO_PR_EXT:spectrin denotes spectrin
T3179 721-730 GO_EXT:biological_movement_or_translocation_process denotes migration
T3180 777-784 GO_EXT:biological_release denotes release
T3181 788-803 GO:0005925 denotes focal adhesions
T3182 794-803 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesions
T3183 834-839 PR_EXT:000005022 denotes Capn4
T3184 877-885 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3185 893-897 SO_EXT:0000704 denotes gene
T3186 922-931 UBERON:0000922 denotes embryonic
T3187 932-941 GO_EXT:fatality_or_lethality denotes lethality
T3188 963-975 GO:0007566 denotes implantation
T3189 1011-1020 UBERON:0000922 denotes embryonic
T3190 1021-1030 GO_EXT:fatality_or_lethality denotes lethality
T3191 1065-1070 PR_EXT:000005022 denotes Capn4
T3192 1070-1071 SO_EXT:sequence_nullness_or_absence denotes -
T3193 1072-1073 SO_EXT:sequence_nullness_or_absence denotes -
T3194 1074-1078 NCBITaxon:10088 denotes mice
T3195 1117-1125 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3196 1215-1224 GO:0007565 denotes gestation
T3197 1252-1257 PR_EXT:000005022 denotes Capn4
T3198 1257-1258 SO_EXT:sequence_nullness_or_absence denotes -
T3199 1259-1260 SO_EXT:sequence_nullness_or_absence denotes -
T3200 1261-1265 NCBITaxon:10088 denotes mice
T3201 1290-1294 SO_EXT:sequence_nullness denotes null
T3202 1295-1303 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3203 1319-1324 PR_EXT:000005009 denotes Capn1
T3204 1326-1334 SO_EXT:sequence_coding_function denotes encoding
T3205 1339-1348 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3206 1339-1366 PR_EXT:000005009 denotes μ-calpain catalytic subunit
T3207 1349-1358 GO_MOP_EXT:catalysis denotes catalytic
T3208 1423-1427 NCBITaxon:10088 denotes mice
T3209 1458-1467 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3210 1473-1482 CL:0000233 denotes platelets
T3211 1553-1558 PR_EXT:000005022 denotes Capn4
T3212 1559-1563 SO_EXT:sequence_nullness denotes null
T3213 1564-1568 NCBITaxon:10088 denotes mice
T3214 1569-1572 GO:0016265 denotes die
T3215 1580-1593 GO:0009790 denotes embryogenesis
T3216 1704-1709 PR_EXT:000005009 denotes Capn1
T3217 1720-1724 NCBITaxon:10088 denotes mice
T3218 1793-1802 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3219 1835-1848 GO:0009790 denotes embryogenesis
T3220 2004-2009 PR_EXT:000005015 denotes Capn2
T3221 2010-2014 SO_EXT:0000704 denotes gene
T3222 2015-2023 SO_EXT:sequence_coding_function denotes encoding
T3223 2028-2042 PR_EXT:000005015 denotes m-80 k subunit
T3224 2046-2050 NCBITaxon:10088 denotes mice
T3225 2072-2077 PR_EXT:000005015 denotes Capn2
T3226 2078-2082 SO_EXT:sequence_nullness denotes null
T3227 2083-2090 UBERON:0000922 denotes embryos
T3228 2091-2095 GO:0016265 denotes died
T3229 2109-2121 GO:0007566 denotes implantation
T3230 2145-2154 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3231 2182-2195 GO:0009790 denotes embryogenesis
T3232 2230-2239 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3233 2250-2259 GO:0010467 denotes expressed
T3234 2263-2272 UBERON:0000922 denotes embryonic
T3235 2263-2277 _FRAGMENT denotes embryonic stem
T3236 2283-2288 CL:0002322 denotes cells
T3237 2279-2281 _FRAGMENT denotes ES
T3238 2283-2288 CL_GO_EXT:cell denotes cells
T3239 2340-2349 GO:0007565 denotes gestation
T3240 2388-2397 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3241 2402-2411 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3242 2426-2439 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T3243 2459-2472 GO:0009790 denotes embryogenesis
R277 T3153 T3152 _lexicallyChainedTo calpain,μ-
R280 T3158 T3157 _lexicallyChainedTo calpain,μ-
R281 T3168 T3167 _lexicallyChainedTo calpain,μ-
R285 T3236 T3235 _lexicallyChainedTo cells,embryonic stem
R286 T3236 T3237 _lexicallyChainedTo cells,ES