PMC:1382200 / 232-498
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1382200","sourcedb":"PMC","sourceid":"1382200","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1382200","text":"es and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (μ-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. Disruption of the mouse Capn4 gene abolished both μ-calpain and m-calpain","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T703","span":{"begin":3,"end":6},"obj":"CC"},{"id":"T704","span":{"begin":7,"end":11},"obj":"NN"},{"id":"T705","span":{"begin":12,"end":17},"obj":"NN"},{"id":"T706","span":{"begin":17,"end":18},"obj":"."},{"id":"T707","span":{"begin":18,"end":192},"obj":"sentence"},{"id":"T708","span":{"begin":19,"end":24},"obj":"DT"},{"id":"T709","span":{"begin":39,"end":46},"obj":"NNS"},{"id":"T710","span":{"begin":25,"end":38},"obj":"JJ"},{"id":"T711","span":{"begin":51,"end":59},"obj":"VBN"},{"id":"T712","span":{"begin":47,"end":50},"obj":"VBP"},{"id":"T713","span":{"begin":60,"end":62},"obj":"IN"},{"id":"T714","span":{"begin":63,"end":71},"obj":"JJ"},{"id":"T715","span":{"begin":82,"end":90},"obj":"NNS"},{"id":"T716","span":{"begin":72,"end":81},"obj":"JJ"},{"id":"T717","span":{"begin":90,"end":92},"obj":","},{"id":"T718","span":{"begin":92,"end":99},"obj":"VBN"},{"id":"T719","span":{"begin":100,"end":102},"obj":"IN"},{"id":"T720","span":{"begin":103,"end":108},"obj":"NN"},{"id":"T721","span":{"begin":109,"end":110},"obj":"-LRB-"},{"id":"T722","span":{"begin":110,"end":111},"obj":"NN"},{"id":"T723","span":{"begin":112,"end":119},"obj":"NN"},{"id":"T724","span":{"begin":111,"end":112},"obj":"HYPH"},{"id":"T725","span":{"begin":119,"end":120},"obj":"-RRB-"},{"id":"T726","span":{"begin":121,"end":123},"obj":"CC"},{"id":"T727","span":{"begin":124,"end":129},"obj":"NN"},{"id":"T728","span":{"begin":130,"end":131},"obj":"-LRB-"},{"id":"T729","span":{"begin":131,"end":132},"obj":"NN"},{"id":"T730","span":{"begin":133,"end":140},"obj":"NN"},{"id":"T731","span":{"begin":132,"end":133},"obj":"HYPH"},{"id":"T732","span":{"begin":140,"end":141},"obj":"-RRB-"},{"id":"T733","span":{"begin":141,"end":143},"obj":","},{"id":"T734","span":{"begin":143,"end":146},"obj":"CC"},{"id":"T735","span":{"begin":147,"end":148},"obj":"DT"},{"id":"T736","span":{"begin":167,"end":174},"obj":"NN"},{"id":"T737","span":{"begin":149,"end":155},"obj":"JJ"},{"id":"T738","span":{"begin":156,"end":166},"obj":"JJ"},{"id":"T739","span":{"begin":175,"end":182},"obj":"VBN"},{"id":"T740","span":{"begin":183,"end":185},"obj":"IN"},{"id":"T741","span":{"begin":186,"end":191},"obj":"NN"},{"id":"T742","span":{"begin":191,"end":192},"obj":"."},{"id":"T744","span":{"begin":193,"end":203},"obj":"NN"},{"id":"T745","span":{"begin":228,"end":237},"obj":"VBD"},{"id":"T746","span":{"begin":204,"end":206},"obj":"IN"},{"id":"T747","span":{"begin":207,"end":210},"obj":"DT"},{"id":"T748","span":{"begin":223,"end":227},"obj":"NN"},{"id":"T749","span":{"begin":211,"end":216},"obj":"NN"},{"id":"T750","span":{"begin":217,"end":222},"obj":"NN"},{"id":"T751","span":{"begin":238,"end":242},"obj":"CC"},{"id":"T752","span":{"begin":245,"end":252},"obj":"NN"},{"id":"T753","span":{"begin":243,"end":244},"obj":"NN"},{"id":"T754","span":{"begin":244,"end":245},"obj":"HYPH"},{"id":"T756","span":{"begin":253,"end":256},"obj":"CC"},{"id":"T757","span":{"begin":257,"end":258},"obj":"NN"},{"id":"T758","span":{"begin":259,"end":266},"obj":"NN"},{"id":"T759","span":{"begin":258,"end":259},"obj":"HYPH"}],"relations":[{"id":"R73","pred":"det","subj":"T747","obj":"T748"},{"id":"R74","pred":"pobj","subj":"T748","obj":"T746"},{"id":"R34","pred":"compound","subj":"T704","obj":"T705"},{"id":"R37","pred":"det","subj":"T708","obj":"T709"},{"id":"R39","pred":"amod","subj":"T710","obj":"T709"},{"id":"R40","pred":"auxpass","subj":"T712","obj":"T711"},{"id":"R41","pred":"prep","subj":"T713","obj":"T711"},{"id":"R42","pred":"amod","subj":"T714","obj":"T715"},{"id":"R44","pred":"amod","subj":"T716","obj":"T715"},{"id":"R45","pred":"punct","subj":"T717","obj":"T715"},{"id":"R46","pred":"acl","subj":"T718","obj":"T715"},{"id":"R47","pred":"agent","subj":"T719","obj":"T718"},{"id":"R48","pred":"pobj","subj":"T720","obj":"T719"},{"id":"R49","pred":"punct","subj":"T721","obj":"T720"},{"id":"R50","pred":"compound","subj":"T722","obj":"T723"},{"id":"R52","pred":"punct","subj":"T724","obj":"T723"},{"id":"R53","pred":"punct","subj":"T725","obj":"T720"},{"id":"R54","pred":"cc","subj":"T726","obj":"T720"},{"id":"R55","pred":"conj","subj":"T727","obj":"T720"},{"id":"R56","pred":"punct","subj":"T728","obj":"T727"},{"id":"R57","pred":"compound","subj":"T729","obj":"T730"},{"id":"R59","pred":"punct","subj":"T731","obj":"T730"},{"id":"R60","pred":"punct","subj":"T732","obj":"T715"},{"id":"R61","pred":"punct","subj":"T733","obj":"T715"},{"id":"R62","pred":"cc","subj":"T734","obj":"T715"},{"id":"R63","pred":"det","subj":"T735","obj":"T736"},{"id":"R64","pred":"conj","subj":"T736","obj":"T715"},{"id":"R65","pred":"amod","subj":"T737","obj":"T736"},{"id":"R66","pred":"amod","subj":"T738","obj":"T736"},{"id":"R67","pred":"acl","subj":"T739","obj":"T736"},{"id":"R68","pred":"agent","subj":"T740","obj":"T739"},{"id":"R69","pred":"pobj","subj":"T741","obj":"T740"},{"id":"R70","pred":"punct","subj":"T742","obj":"T711"},{"id":"R71","pred":"nsubj","subj":"T744","obj":"T745"},{"id":"R72","pred":"prep","subj":"T746","obj":"T744"},{"id":"R75","pred":"compound","subj":"T749","obj":"T748"},{"id":"R76","pred":"compound","subj":"T750","obj":"T748"},{"id":"R77","pred":"preconj","subj":"T751","obj":"T752"},{"id":"R79","pred":"nmod","subj":"T753","obj":"T752"},{"id":"R80","pred":"punct","subj":"T754","obj":"T752"},{"id":"R82","pred":"cc","subj":"T756","obj":"T752"},{"id":"R83","pred":"compound","subj":"T757","obj":"T758"},{"id":"R84","pred":"conj","subj":"T758","obj":"T752"},{"id":"R85","pred":"punct","subj":"T759","obj":"T758"},{"id":"R38","pred":"nsubjpass","subj":"T709","obj":"T711"},{"id":"R43","pred":"pobj","subj":"T715","obj":"T713"},{"id":"R51","pred":"appos","subj":"T723","obj":"T720"},{"id":"R58","pred":"appos","subj":"T730","obj":"T727"}],"attributes":[{"subj":"T703","pred":"source","obj":"craft-sa-dev"},{"subj":"T704","pred":"source","obj":"craft-sa-dev"},{"subj":"T705","pred":"source","obj":"craft-sa-dev"},{"subj":"T706","pred":"source","obj":"craft-sa-dev"},{"subj":"T707","pred":"source","obj":"craft-sa-dev"},{"subj":"T708","pred":"source","obj":"craft-sa-dev"},{"subj":"T709","pred":"source","obj":"craft-sa-dev"},{"subj":"T710","pred":"source","obj":"craft-sa-dev"},{"subj":"T711","pred":"source","obj":"craft-sa-dev"},{"subj":"T712","pred":"source","obj":"craft-sa-dev"},{"subj":"T713","pred":"source","obj":"craft-sa-dev"},{"subj":"T714","pred":"source","obj":"craft-sa-dev"},{"subj":"T715","pred":"source","obj":"craft-sa-dev"},{"subj":"T716","pred":"source","obj":"craft-sa-dev"},{"subj":"T717","pred":"source","obj":"craft-sa-dev"},{"subj":"T718","pred":"source","obj":"craft-sa-dev"},{"subj":"T719","pred":"source","obj":"craft-sa-dev"},{"subj":"T720","pred":"source","obj":"craft-sa-dev"},{"subj":"T721","pred":"source","obj":"craft-sa-dev"},{"subj":"T722","pred":"source","obj":"craft-sa-dev"},{"subj":"T723","pred":"source","obj":"craft-sa-dev"},{"subj":"T724","pred":"source","obj":"craft-sa-dev"},{"subj":"T725","pred":"source","obj":"craft-sa-dev"},{"subj":"T726","pred":"source","obj":"craft-sa-dev"},{"subj":"T727","pred":"source","obj":"craft-sa-dev"},{"subj":"T728","pred":"source","obj":"craft-sa-dev"},{"subj":"T729","pred":"source","obj":"craft-sa-dev"},{"subj":"T730","pred":"source","obj":"craft-sa-dev"},{"subj":"T731","pred":"source","obj":"craft-sa-dev"},{"subj":"T732","pred":"source","obj":"craft-sa-dev"},{"subj":"T733","pred":"source","obj":"craft-sa-dev"},{"subj":"T734","pred":"source","obj":"craft-sa-dev"},{"subj":"T735","pred":"source","obj":"craft-sa-dev"},{"subj":"T736","pred":"source","obj":"craft-sa-dev"},{"subj":"T737","pred":"source","obj":"craft-sa-dev"},{"subj":"T738","pred":"source","obj":"craft-sa-dev"},{"subj":"T739","pred":"source","obj":"craft-sa-dev"},{"subj":"T740","pred":"source","obj":"craft-sa-dev"},{"subj":"T741","pred":"source","obj":"craft-sa-dev"},{"subj":"T742","pred":"source","obj":"craft-sa-dev"},{"subj":"T744","pred":"source","obj":"craft-sa-dev"},{"subj":"T745","pred":"source","obj":"craft-sa-dev"},{"subj":"T746","pred":"source","obj":"craft-sa-dev"},{"subj":"T747","pred":"source","obj":"craft-sa-dev"},{"subj":"T748","pred":"source","obj":"craft-sa-dev"},{"subj":"T749","pred":"source","obj":"craft-sa-dev"},{"subj":"T750","pred":"source","obj":"craft-sa-dev"},{"subj":"T751","pred":"source","obj":"craft-sa-dev"},{"subj":"T752","pred":"source","obj":"craft-sa-dev"},{"subj":"T753","pred":"source","obj":"craft-sa-dev"},{"subj":"T754","pred":"source","obj":"craft-sa-dev"},{"subj":"T756","pred":"source","obj":"craft-sa-dev"},{"subj":"T757","pred":"source","obj":"craft-sa-dev"},{"subj":"T758","pred":"source","obj":"craft-sa-dev"},{"subj":"T759","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T540","span":{"begin":7,"end":17},"obj":"GO:0008219"},{"id":"T541","span":{"begin":103,"end":108},"obj":"PR:000005009"},{"id":"T542","span":{"begin":124,"end":129},"obj":"PR:000005015"},{"id":"T543","span":{"begin":156,"end":166},"obj":"GO:0065007"},{"id":"T544","span":{"begin":186,"end":191},"obj":"PR:000005022"},{"id":"T545","span":{"begin":211,"end":216},"obj":"NCBITaxon:10088"},{"id":"T546","span":{"begin":217,"end":222},"obj":"PR:000005022"},{"id":"T547","span":{"begin":223,"end":227},"obj":"SO:0000704"}],"attributes":[{"subj":"T540","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T541","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T542","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T543","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T544","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T545","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T546","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T547","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T595","span":{"begin":7,"end":11},"obj":"CL_GO_EXT:cell"},{"id":"T596","span":{"begin":7,"end":17},"obj":"GO:0008219"},{"id":"T597","span":{"begin":31,"end":38},"obj":"GO_EXT:dimer_macromolecular_complex"},{"id":"T598","span":{"begin":39,"end":46},"obj":"CHEBI_GO_SO_EXT:enzyme"},{"id":"T599","span":{"begin":72,"end":81},"obj":"GO_MOP_EXT:catalysis"},{"id":"T600","span":{"begin":92,"end":99},"obj":"SO_EXT:sequence_coding_function"},{"id":"T601","span":{"begin":103,"end":108},"obj":"PR_EXT:000005009"},{"id":"T602","span":{"begin":110,"end":119},"obj":"GO_PR_EXT:calpain_1_complex"},{"id":"T603","span":{"begin":124,"end":129},"obj":"PR_EXT:000005015"},{"id":"T604","span":{"begin":131,"end":140},"obj":"GO_PR_EXT:calpain_2_complex"},{"id":"T605","span":{"begin":156,"end":166},"obj":"GO:0065007"},{"id":"T606","span":{"begin":175,"end":182},"obj":"SO_EXT:sequence_coding_function"},{"id":"T607","span":{"begin":186,"end":191},"obj":"PR_EXT:000005022"},{"id":"T608","span":{"begin":211,"end":216},"obj":"NCBITaxon:10088"},{"id":"T609","span":{"begin":217,"end":222},"obj":"PR_EXT:000005022"},{"id":"T610","span":{"begin":223,"end":227},"obj":"SO_EXT:0000704"},{"id":"T611","span":{"begin":243,"end":252},"obj":"GO_PR_EXT:calpain_1_complex"},{"id":"T612","span":{"begin":257,"end":266},"obj":"GO_PR_EXT:calpain_2_complex"}],"attributes":[{"subj":"T595","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T596","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T597","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T598","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T599","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T600","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T601","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T602","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T603","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T604","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T605","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T606","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T607","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T608","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T609","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T610","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T611","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T612","pred":"source","obj":"craft-ca-core-ex-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#e4ec93","default":true},{"id":"craft-ca-core-dev","color":"#da93ec"},{"id":"craft-ca-core-ex-dev","color":"#93ecc0"}]}]}}