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PMC:1382200 / 21686-23719 JSONTXT

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Id Subject Object Predicate Lexical cue
T14185 2032-2033 . denotes .
T14184 2024-2032 JJ denotes distinct
T14183 2011-2012 HYPH denotes -
T14182 2012-2019 NN denotes calpain
T14181 2010-2011 NN denotes m
T14180 2006-2009 CC denotes and
T14179 1997-1998 HYPH denotes -
T14178 1998-2005 NN denotes calpain
T14177 1996-1997 NN denotes μ
T14176 1993-1995 IN denotes of
T14175 1978-1982 DT denotes some
T14174 1983-1992 NNS denotes functions
T14173 1972-1977 RBS denotes least
T14172 1969-1971 RB denotes at
T14171 2020-2023 VBP denotes are
T14170 1964-1968 IN denotes that
T14169 1956-1963 VBZ denotes follows
T14168 1953-1955 PRP denotes It
T14167 1952-2033 sentence denotes It follows that at least some functions of μ-calpain and m-calpain are distinct.
T14166 1951-1952 . denotes .
T14165 1940-1941 HYPH denotes -
T14164 1941-1945 NN denotes cell
T14163 1939-1940 CD denotes 8
T14162 1946-1951 NN denotes stage
T14161 1935-1938 DT denotes the
T14040 1319-1326 NNS denotes amounts
T14039 1304-1309 PRP$ denotes their
T14038 1301-1303 IN denotes of
T14037 1291-1300 NNS denotes estimates
T14036 1282-1290 JJ denotes reliable
T14035 1270-1273 RB denotes not
T14034 1267-1269 VBP denotes do
T14033 1265-1267 , denotes ,
T14032 1244-1253 JJ denotes available
T14031 1254-1265 NN denotes methodology
T14030 1240-1243 DT denotes the
T14029 1237-1239 IN denotes in
T14028 1226-1236 NNS denotes weaknesses
T14027 1223-1225 IN denotes to
T14026 1217-1222 VBG denotes owing
T14025 1215-1217 , denotes ,
T14024 1201-1210 VBN denotes published
T14023 1211-1215 NNS denotes data
T14022 1197-1200 DT denotes the
T14021 1274-1281 VB denotes provide
T14020 1188-1196 IN denotes although
T14019 1186-1188 , denotes ,
T14018 1171-1180 JJ denotes mammalian
T14017 1181-1186 NNS denotes cells
T14016 1166-1170 JJS denotes most
T14015 1163-1165 IN denotes in
T14014 1155-1162 JJ denotes present
T14013 1151-1154 VBP denotes are
T14012 1131-1132 HYPH denotes -
T14011 1130-1131 NN denotes m
T14010 1126-1129 CC denotes and
T14009 1124-1125 HYPH denotes -
T14008 1132-1139 NN denotes calpain
T14007 1123-1124 NN denotes μ
T14006 1140-1150 NNS denotes activities
T14005 1118-1122 CC denotes Both
T14004 1117-1327 sentence denotes Both μ- and m-calpain activities are present in most mammalian cells, although the published data, owing to weaknesses in the available methodology, do not provide reliable estimates of their relative amounts.
T14003 1116-1117 . denotes .
T14002 1106-1116 NN denotes activation
T14001 1097-1105 NN denotes platelet
T14000 1094-1096 IN denotes in
T13999 1085-1093 VBN denotes involved
T13998 1076-1084 NN denotes proteins
T13997 1068-1075 JJ denotes certain
T13996 1065-1067 IN denotes of
T13995 1040-1048 NN denotes tyrosine
T13994 1049-1064 NN denotes phosphorylation
T13993 1036-1039 DT denotes the
T13992 1033-1035 IN denotes of
T13991 1027-1032 NN denotes level
T13990 1023-1026 DT denotes the
T13989 1020-1022 IN denotes at
T13988 1011-1019 RB denotes possibly
T13987 1009-1011 , denotes ,
T13986 1001-1009 NN denotes function
T13985 992-1000 NN denotes platelet
T13984 989-991 IN denotes in
T13983 977-988 NN denotes disturbance
T13982 975-976 DT denotes a
T13981 955-965 NN denotes deficiency
T13980 949-954 NN denotes Capn1
T13979 946-948 IN denotes of
T13978 939-945 NN denotes result
T13977 937-938 DT denotes a
T13976 934-936 IN denotes as
T13975 925-933 VBN denotes observed
T13974 966-974 VBD denotes involved
T13973 905-914 JJ denotes principal
T13972 915-924 NN denotes phenotype
T13971 901-904 DT denotes The
T13970 900-1117 sentence denotes The principal phenotype observed as a result of Capn1 deficiency involved a disturbance in platelet function, possibly at the level of the tyrosine phosphorylation of certain proteins involved in platelet activation.
T13969 899-900 . denotes .
T13968 898-899 -RRB- denotes ]
T13967 896-898 CD denotes 33
T13966 895-896 -LRB- denotes [
T13965 890-894 NNS denotes mice
T13964 887-889 IN denotes of
T13963 877-886 NN denotes viability
T13962 873-876 DT denotes the
T13961 862-865 RB denotes not
T13960 858-861 VBD denotes did
T13959 856-858 , denotes ,
T13958 851-856 NN denotes Capn1
T13957 849-851 , denotes ,
T13956 837-844 NN denotes subunit
T13955 831-836 JJ denotes large
T13954 822-823 HYPH denotes -
T13953 823-830 NN denotes calpain
T13952 821-822 NN denotes μ
T13951 845-849 NN denotes gene
T13950 817-820 DT denotes the
T13949 814-816 IN denotes of
T13948 803-813 NN denotes disruption
T13947 792-802 JJ denotes homozygous
T13946 790-792 , denotes ,
T13945 778-790 NN denotes implantation
T13944 775-777 IN denotes to
T13943 769-774 JJ denotes prior
T13942 750-756 JJ denotes murine
T13941 757-764 NNS denotes embryos
T13940 745-749 JJ denotes null
T13939 739-744 NN denotes Capn2
T13938 765-768 VBP denotes die
T13937 731-738 IN denotes whereas
T13936 729-731 , denotes ,
T13935 866-872 VB denotes affect
T13934 724-729 VBN denotes noted
T13933 721-723 IN denotes As
T13932 720-900 sentence denotes As noted, whereas Capn2 null murine embryos die prior to implantation, homozygous disruption of the μ-calpain large subunit gene, Capn1, did not affect the viability of mice [33].
T13931 719-720 . denotes .
T13930 706-719 NN denotes embryogenesis
T13929 699-705 IN denotes during
T13928 693-698 RBS denotes least
T13927 690-692 RB denotes at
T13926 688-690 , denotes ,
T13925 669-682 JJ denotes physiological
T13924 660-668 JJ denotes distinct
T13923 683-688 NNS denotes roles
T13922 655-659 DT denotes some
T13921 641-642 HYPH denotes -
T13920 640-641 NN denotes m
T13919 636-639 CC denotes and
T13918 634-635 HYPH denotes -
T13917 642-649 NN denotes calpain
T13916 633-634 NN denotes μ
T13915 650-654 VBP denotes have
T13914 628-632 IN denotes that
T13913 626-628 , denotes ,
T13912 622-626 NNS denotes mice
T13911 619-621 IN denotes in
T13910 614-618 VBN denotes done
T13909 599-608 NN denotes targeting
T13908 594-598 NN denotes gene
T13907 609-613 NN denotes work
T13906 590-593 DT denotes the
T13905 585-589 IN denotes from
T13904 583-585 , denotes ,
T13903 578-583 JJ denotes clear
T13902 574-577 RB denotes now
T13901 571-573 VBZ denotes is
T13900 568-570 PRP denotes It
T13899 567-720 sentence denotes It is now clear, from the gene targeting work done in mice, that μ- and m-calpain have some distinct physiological roles, at least during embryogenesis.
T13898 566-567 . denotes .
T13897 561-566 NNS denotes cells
T13896 554-560 IN denotes inside
T13895 529-543 RB denotes differentially
T13894 525-528 VBP denotes are
T13893 512-515 CD denotes two
T13892 516-524 NNS denotes isoforms
T13891 508-511 DT denotes the
T13890 544-553 VBN denotes regulated
T13889 503-507 IN denotes that
T13888 494-502 JJ denotes possible
T13887 488-490 PRP denotes it
T13886 486-488 , denotes ,
T13885 476-486 NN denotes activation
T13884 470-475 FW denotes vitro
T13883 467-469 FW denotes in
T13882 463-466 IN denotes for
T13881 461-462 SYM denotes +
T13880 458-461 NN denotes Ca2
T13879 455-457 IN denotes of
T13878 447-454 NNS denotes amounts
T13877 437-446 JJ denotes different
T13876 424-428 PRP denotes they
T13875 429-436 VBP denotes require
T13874 418-423 IN denotes since
T13873 416-418 , denotes ,
T13872 406-411 JJ denotes other
T13871 412-416 NN denotes hand
T13870 402-405 DT denotes the
T13869 491-493 VBZ denotes is
T13868 399-401 IN denotes On
T13867 398-567 sentence denotes On the other hand, since they require different amounts of Ca2+ for in vitro activation, it is possible that the two isoforms are differentially regulated inside cells.
T13866 397-398 . denotes .
T13865 393-397 FW denotes vivo
T13864 390-392 FW denotes in
T13863 375-379 JJ denotes same
T13862 380-389 NNS denotes functions
T13861 371-374 DT denotes the
T13860 367-370 RP denotes out
T13859 361-366 VB denotes carry
T13858 358-360 TO denotes to
T13857 348-357 NN denotes potential
T13856 344-347 DT denotes the
T13855 334-338 PRP denotes they
T13854 339-343 VBP denotes have
T13853 329-333 IN denotes that
T13852 318-328 VBG denotes suggesting
T13851 316-318 , denotes ,
T13850 311-316 FW denotes vitro
T13849 308-310 FW denotes in
T13848 297-307 NNS denotes substrates
T13847 294-296 IN denotes of
T13846 285-289 JJ denotes same
T13845 290-293 NN denotes set
T13844 281-284 DT denotes the
T13843 269-280 RB denotes essentially
T13842 257-261 PRP denotes they
T13841 255-257 , denotes ,
T13840 262-268 VBP denotes cleave
T13839 248-255 RB denotes Notably
T13838 247-398 sentence denotes Notably, they cleave essentially the same set of substrates in vitro, suggesting that they have the potential to carry out the same functions in vivo.
T13837 246-247 . denotes .
T13836 234-246 NN denotes biochemistry
T13835 230-233 CC denotes and
T13834 220-229 NN denotes structure
T13833 214-219 PRP$ denotes their
T13832 211-213 IN denotes in
T13831 203-210 JJ denotes similar
T13830 198-202 RB denotes very
T13829 194-197 VBP denotes are
T13828 190-193 CC denotes and
T13827 172-180 NN denotes sequence
T13826 181-189 NN denotes identity
T13825 170-171 NN denotes %
T14160 1928-1934 IN denotes beyond
T14159 1916-1927 NN denotes development
T14158 1906-1915 JJ denotes embryonic
T14157 1902-1905 IN denotes for
T14156 1892-1901 JJ denotes essential
T14155 1880-1888 NN denotes activity
T14154 1871-1872 HYPH denotes -
T14153 1872-1879 NN denotes calpain
T14152 1870-1871 NN denotes m
T14151 1889-1891 VBZ denotes is
T14150 1865-1869 IN denotes that
T14149 1842-1843 SYM denotes -
T14148 1841-1842 HYPH denotes /
T14147 1840-1841 SYM denotes -
T14146 1844-1851 NNS denotes embryos
T14145 1835-1840 NN denotes Capn2
T14144 1832-1834 IN denotes in
T14143 1822-1831 NN denotes lethality
T14142 1820-1822 , denotes ,
T14141 1812-1820 NN denotes contrast
T14140 1852-1864 VBZ denotes demonstrates
T14139 1809-1811 IN denotes In
T14138 1808-1952 sentence denotes In contrast, lethality in Capn2-/- embryos demonstrates that m-calpain activity is essential for embryonic development beyond the 8-cell stage.
T14137 1807-1808 . denotes .
T14136 1798-1807 JJ denotes essential
T14135 1794-1797 RB denotes not
T14134 1787-1793 RB denotes simply
T14133 1774-1775 HYPH denotes -
T14132 1775-1782 NN denotes calpain
T14131 1773-1774 NN denotes μ
T14130 1770-1772 IN denotes of
T14129 1760-1769 NNS denotes functions
T14128 1756-1759 DT denotes the
T14127 1783-1786 VBP denotes are
T14126 1748-1755 IN denotes whether
T14125 1745-1747 CC denotes or
T14124 1743-1745 , denotes ,
T14123 1726-1727 HYPH denotes -
T14122 1727-1734 NN denotes calpain
T14121 1725-1726 NN denotes m
T14120 1715-1724 VBG denotes remaining
T14119 1735-1743 NN denotes activity
T14118 1711-1714 DT denotes the
T14117 1708-1710 IN denotes by
T14116 1688-1700 JJ denotes compensatory
T14115 1701-1707 NN denotes affect
T14114 1686-1687 DT denotes a
T14113 1683-1685 IN denotes to
T14112 1679-1682 IN denotes due
T14111 1666-1667 SYM denotes -
T14110 1665-1666 HYPH denotes /
T14109 1664-1665 SYM denotes -
T14108 1668-1675 NNS denotes animals
T14107 1659-1664 NN denotes Capn1
T14106 1656-1658 IN denotes in
T14105 1646-1655 NN denotes phenotype
T14104 1639-1645 JJ denotes marked
T14103 1636-1638 IN denotes of
T14102 1628-1635 NN denotes absence
T14101 1624-1627 DT denotes the
T14100 1676-1678 VBZ denotes is
T14099 1616-1623 IN denotes whether
T14098 1606-1615 VB denotes determine
T14097 1603-1605 TO denotes to
T14096 1594-1602 JJ denotes possible
T14095 1590-1593 RB denotes not
T14094 1584-1586 PRP denotes it
T14093 1582-1584 , denotes ,
T14092 1576-1582 NN denotes result
T14091 1574-1575 DT denotes a
T14090 1587-1589 VBZ denotes is
T14089 1571-1573 IN denotes As
T14088 1570-1808 sentence denotes As a result, it is not possible to determine whether the absence of marked phenotype in Capn1-/- animals is due to a compensatory affect by the remaining m-calpain activity, or whether the functions of μ-calpain are simply not essential.
T14087 1569-1570 . denotes .
T14086 1559-1563 NN denotes cell
T14085 1564-1569 NNS denotes types
T14084 1553-1558 JJ denotes other
T14083 1550-1552 IN denotes in
T14082 1545-1549 IN denotes than
T14081 1532-1544 NNS denotes erythrocytes
T14080 1528-1531 CC denotes and
T14079 1518-1527 NNS denotes platelets
T14078 1515-1517 IN denotes in
T14077 1508-1514 JJ denotes likely
T14076 1503-1507 RBR denotes less
T14075 1493-1502 RB denotes therefore
T14074 1481-1482 HYPH denotes -
T14073 1482-1489 NN denotes calpain
T14072 1480-1481 NN denotes m
T14071 1477-1479 IN denotes by
T14070 1466-1476 NN denotes deficiency
T14069 1457-1458 HYPH denotes -
T14068 1458-1465 NN denotes calpain
T14067 1456-1457 NN denotes μ
T14066 1452-1455 IN denotes for
T14065 1490-1492 VBZ denotes is
T14064 1439-1451 NN denotes Compensation
T14063 1438-1570 sentence denotes Compensation for μ-calpain deficiency by m-calpain is therefore less likely in platelets and erythrocytes than in other cell types.
T14062 1437-1438 . denotes .
T14061 1427-1437 JJ denotes detectable
T14060 1420-1426 RB denotes barely
T14059 1408-1416 NN denotes activity
T14058 1399-1400 HYPH denotes -
T14057 1400-1407 NN denotes calpain
T14056 1398-1399 NN denotes m
T14055 1417-1419 VBZ denotes is
T14054 1392-1397 IN denotes while
T14053 1390-1392 , denotes ,
T14052 1373-1374 HYPH denotes -
T14051 1374-1381 NN denotes calpain
T14050 1372-1373 NN denotes μ
T14049 1382-1390 NN denotes activity
T14048 1363-1371 JJ denotes abundant
T14047 1342-1354 NNS denotes erythrocytes
T14046 1338-1341 CC denotes and
T14045 1355-1362 VBP denotes contain
T14044 1328-1337 NNS denotes Platelets
T14043 1327-1438 sentence denotes Platelets and erythrocytes contain abundant μ-calpain activity, while m-calpain activity is barely detectable.
T14042 1326-1327 . denotes .
T14041 1310-1318 JJ denotes relative
T13824 168-170 CD denotes 62
T13823 162-167 VBP denotes share
T13822 150-153 CD denotes two
T13821 154-161 NNS denotes enzymes
T13820 146-149 DT denotes The
T13819 145-247 sentence denotes The two enzymes share 62% sequence identity and are very similar in their structure and biochemistry.
T13818 144-145 . denotes .
T13817 134-138 FW denotes vivo
T13816 131-133 FW denotes in
T13815 139-144 NNS denotes roles
T13814 122-130 JJ denotes distinct
T13813 112-114 , denotes ,
T13812 104-105 HYPH denotes -
T13811 103-104 NN denotes m
T13810 99-102 CC denotes and
T13809 97-98 HYPH denotes -
T13808 105-112 NN denotes calpain
T13807 96-97 NN denotes μ
T13806 94-96 , denotes ,
T13805 75-85 JJ denotes ubiquitous
T13804 71-74 CD denotes two
T13803 86-94 NNS denotes isoforms
T13802 67-70 DT denotes the
T13801 114-121 VBP denotes possess
T13800 59-66 IN denotes whether
T13799 50-53 VBZ denotes has
T13798 41-49 NN denotes research
T13797 33-40 NN denotes calpain
T13796 30-32 IN denotes in
T13795 11-19 VBG denotes enduring
T13794 20-29 NNS denotes questions
T13793 7-10 DT denotes the
T13792 4-6 IN denotes of
T13791 54-58 VBN denotes been
T13790 0-3 CD denotes One
R3221 T13790 T13791 nsubj One,been
R3223 T13792 T13790 prep of,One
R3224 T13793 T13794 det the,questions
R3225 T13794 T13792 pobj questions,of
R3227 T13795 T13794 amod enduring,questions
R3228 T13796 T13794 prep in,questions
R3229 T13797 T13798 compound calpain,research
R3231 T13798 T13796 pobj research,in
R3232 T13799 T13791 aux has,been
R3233 T13800 T13801 mark whether,possess
R3235 T13801 T13791 ccomp possess,been
R3236 T13802 T13803 det the,isoforms
R3237 T13803 T13801 nsubj isoforms,possess
R3239 T13804 T13803 nummod two,isoforms
R3240 T13805 T13803 amod ubiquitous,isoforms
R3241 T13806 T13803 punct ", ",isoforms
R3242 T13807 T13808 nmod μ,calpain
R3243 T13808 T13803 appos calpain,isoforms
R3245 T13809 T13807 punct -,μ
R3246 T13810 T13807 cc and,μ
R3247 T13811 T13807 conj m,μ
R3248 T13812 T13808 punct -,calpain
R3250 T13813 T13801 punct ", ",possess
R3251 T13814 T13815 amod distinct,roles
R3253 T13815 T13801 dobj roles,possess
R3254 T13816 T13817 advmod in,vivo
R3255 T13817 T13815 amod vivo,roles
R3257 T13818 T13791 punct .,been
R3258 T13820 T13821 det The,enzymes
R3260 T13821 T13823 nsubj enzymes,share
R3261 T13822 T13821 nummod two,enzymes
R3263 T13824 T13825 nummod 62,%
R3264 T13825 T13826 compound %,identity
R3266 T13826 T13823 dobj identity,share
R3267 T13827 T13826 compound sequence,identity
R3268 T13828 T13823 cc and,share
R3272 T13829 T13823 conj are,share
R3273 T13830 T13831 advmod very,similar
R3275 T13831 T13829 acomp similar,are
R3276 T13832 T13829 prep in,are
R3277 T13833 T13834 poss their,structure
R3279 T13834 T13832 pobj structure,in
R3280 T13835 T13834 cc and,structure
R3282 T13836 T13834 conj biochemistry,structure
R3283 T13837 T13823 punct .,share
R3285 T13839 T13840 advmod Notably,cleave
R3287 T13841 T13840 punct ", ",cleave
R3288 T13842 T13840 nsubj they,cleave
R3289 T13843 T13840 advmod essentially,cleave
R3292 T13844 T13845 det the,set
R3293 T13845 T13840 dobj set,cleave
R3295 T13846 T13845 amod same,set
R3296 T13847 T13845 prep of,set
R3297 T13848 T13847 pobj substrates,of
R3299 T13849 T13850 advmod in,vitro
R3300 T13850 T13840 advmod vitro,cleave
R3302 T13851 T13840 punct ", ",cleave
R3303 T13852 T13840 advcl suggesting,cleave
R3305 T13853 T13854 mark that,have
R3306 T13854 T13852 ccomp have,suggesting
R3307 T13855 T13854 nsubj they,have
R3309 T13856 T13857 det the,potential
R3310 T13857 T13854 dobj potential,have
R3312 T13858 T13859 aux to,carry
R3313 T13859 T13857 acl carry,potential
R3314 T13860 T13859 prt out,carry
R3316 T13861 T13862 det the,functions
R3317 T13862 T13859 dobj functions,carry
R3318 T13863 T13862 amod same,functions
R3320 T13864 T13865 advmod in,vivo
R3321 T13865 T13859 advmod vivo,carry
R3323 T13866 T13840 punct .,cleave
R3325 T13868 T13869 prep On,is
R3327 T13870 T13871 det the,hand
R3328 T13871 T13868 pobj hand,On
R3329 T13872 T13871 amod other,hand
R3331 T13873 T13869 punct ", ",is
R3332 T13874 T13875 mark since,require
R3333 T13875 T13869 advcl require,is
R3335 T13876 T13875 nsubj they,require
R3336 T13877 T13878 amod different,amounts
R3337 T13878 T13875 dobj amounts,require
R3339 T13879 T13878 prep of,amounts
R3340 T13880 T13879 pobj Ca2,of
R3341 T13881 T13880 punct +,Ca2
R3343 T13882 T13875 prep for,require
R3344 T13883 T13884 nmod in,vitro
R3345 T13884 T13885 nmod vitro,activation
R3346 T13885 T13882 pobj activation,for
R3347 T13886 T13869 punct ", ",is
R3349 T13887 T13869 nsubj it,is
R3350 T13888 T13869 acomp possible,is
R3351 T13889 T13890 mark that,regulated
R3353 T13890 T13869 ccomp regulated,is
R3354 T13891 T13892 det the,isoforms
R3356 T13892 T13890 nsubjpass isoforms,regulated
R3357 T13893 T13892 nummod two,isoforms
R3359 T13894 T13890 auxpass are,regulated
R3360 T13895 T13890 advmod differentially,regulated
R3361 T13896 T13890 prep inside,regulated
R3363 T13897 T13896 pobj cells,inside
R3364 T13898 T13869 punct .,is
R3366 T13900 T13901 nsubj It,is
R3368 T13902 T13901 advmod now,is
R3369 T13903 T13901 acomp clear,is
R3370 T13904 T13901 punct ", ",is
R3372 T13905 T13901 prep from,is
R3373 T13906 T13907 det the,work
R3374 T13907 T13905 pobj work,from
R3376 T13908 T13909 compound gene,targeting
R3377 T13909 T13907 compound targeting,work
R3378 T13910 T13907 acl done,work
R3380 T13911 T13910 prep in,done
R3381 T13912 T13911 pobj mice,in
R3383 T13913 T13901 punct ", ",is
R3384 T13914 T13915 mark that,have
R3385 T13915 T13901 ccomp have,is
R3387 T13916 T13917 nmod μ,calpain
R3388 T13917 T13915 nsubj calpain,have
R3389 T13918 T13916 punct -,μ
R3391 T13919 T13916 cc and,μ
R3392 T13920 T13916 conj m,μ
R3393 T13921 T13917 punct -,calpain
R3395 T13922 T13923 det some,roles
R3396 T13923 T13915 dobj roles,have
R3397 T13924 T13923 amod distinct,roles
R3398 T13925 T13923 amod physiological,roles
R3399 T13926 T13915 punct ", ",have
R3401 T13927 T13928 advmod at,least
R3402 T13928 T13929 advmod least,during
R3404 T13929 T13915 prep during,have
R3406 T13930 T13929 pobj embryogenesis,during
R3407 T13931 T13901 punct .,is
R3409 T13933 T13934 mark As,noted
R3411 T13934 T13935 advcl noted,affect
R3414 T13936 T13935 punct ", ",affect
R3416 T13937 T13938 mark whereas,die
R3417 T13938 T13935 advcl die,affect
R3419 T13939 T13940 npadvmod Capn2,null
R3420 T13940 T13941 amod null,embryos
R3421 T13941 T13938 nsubj embryos,die
R3423 T13942 T13941 amod murine,embryos
R3424 T13943 T13944 amod prior,to
R3426 T13944 T13938 prep to,die
R3427 T13945 T13944 pobj implantation,to
R3428 T13946 T13935 punct ", ",affect
R3430 T13947 T13948 amod homozygous,disruption
R3431 T13948 T13935 nsubj disruption,affect
R3432 T13949 T13948 prep of,disruption
R3434 T13950 T13951 det the,gene
R3435 T13951 T13949 pobj gene,of
R3437 T13952 T13953 nmod μ,calpain
R3438 T13953 T13951 nmod calpain,gene
R3439 T13954 T13953 punct -,calpain
R3441 T13955 T13951 amod large,gene
R3442 T13956 T13951 compound subunit,gene
R3444 T13957 T13951 punct ", ",gene
R3445 T13958 T13951 appos Capn1,gene
R3446 T13959 T13935 punct ", ",affect
R3447 T13960 T13935 aux did,affect
R3448 T13961 T13935 neg not,affect
R3449 T13962 T13963 det the,viability
R3450 T14041 T14040 amod relative,amounts
R3451 T13963 T13935 dobj viability,affect
R3452 T13964 T13963 prep of,viability
R3453 T13965 T13964 pobj mice,of
R3454 T13966 T13967 punct [,33
R3455 T13967 T13935 parataxis 33,affect
R3456 T13968 T13967 punct ],33
R3457 T14042 T14013 punct .,are
R3458 T13969 T13935 punct .,affect
R3459 T13971 T13972 det The,phenotype
R3460 T14044 T14045 nsubj Platelets,contain
R3461 T13972 T13974 nsubj phenotype,involved
R3462 T13973 T13972 amod principal,phenotype
R3463 T14046 T14044 cc and,Platelets
R3464 T13975 T13972 acl observed,phenotype
R3465 T13976 T13975 prep as,observed
R3466 T13977 T13978 det a,result
R3467 T13978 T13976 pobj result,as
R3468 T14047 T14044 conj erythrocytes,Platelets
R3469 T13979 T13978 prep of,result
R3470 T13980 T13981 compound Capn1,deficiency
R3471 T13981 T13979 pobj deficiency,of
R3472 T14048 T14049 amod abundant,activity
R3473 T13982 T13983 det a,disturbance
R3474 T13983 T13974 dobj disturbance,involved
R3475 T13984 T13983 prep in,disturbance
R3476 T14049 T14045 dobj activity,contain
R3477 T13985 T13986 compound platelet,function
R3478 T13986 T13984 pobj function,in
R3479 T13987 T13983 punct ", ",disturbance
R3480 T14050 T14051 compound μ,calpain
R3481 T13988 T13989 advmod possibly,at
R3482 T13989 T13983 prep at,disturbance
R3483 T13990 T13991 det the,level
R3484 T14051 T14049 compound calpain,activity
R3485 T13991 T13989 pobj level,at
R3486 T13992 T13991 prep of,level
R3487 T13993 T13994 det the,phosphorylation
R3488 T14052 T14051 punct -,calpain
R3489 T13994 T13992 pobj phosphorylation,of
R3490 T13995 T13994 compound tyrosine,phosphorylation
R3491 T13996 T13994 prep of,phosphorylation
R3492 T14053 T14045 punct ", ",contain
R3493 T13997 T13998 amod certain,proteins
R3494 T13998 T13996 pobj proteins,of
R3495 T13999 T13998 acl involved,proteins
R3496 T14054 T14055 mark while,is
R3497 T14055 T14045 advcl is,contain
R3498 T14000 T13999 prep in,involved
R3499 T14001 T14002 compound platelet,activation
R3500 T14002 T14000 pobj activation,in
R3501 T14003 T13974 punct .,involved
R3502 T14056 T14057 compound m,calpain
R3503 T14005 T14006 preconj Both,activities
R3504 T14006 T14013 nsubj activities,are
R3505 T14057 T14059 compound calpain,activity
R3506 T14007 T14008 nmod μ,calpain
R3507 T14008 T14006 compound calpain,activities
R3508 T14009 T14007 punct -,μ
R3509 T14058 T14057 punct -,calpain
R3510 T14010 T14007 cc and,μ
R3511 T14011 T14007 conj m,μ
R3512 T14012 T14008 punct -,calpain
R3513 T14059 T14055 nsubj activity,is
R3514 T14014 T14013 acomp present,are
R3515 T14060 T14061 advmod barely,detectable
R3516 T14015 T14013 prep in,are
R3517 T14061 T14055 acomp detectable,is
R3518 T14062 T14045 punct .,contain
R3519 T14016 T14017 amod most,cells
R3520 T14017 T14015 pobj cells,in
R3521 T14018 T14017 amod mammalian,cells
R3522 T14064 T14065 nsubj Compensation,is
R3523 T14019 T14013 punct ", ",are
R3524 T14020 T14021 mark although,provide
R3525 T14066 T14064 prep for,Compensation
R3526 T14021 T14013 advcl provide,are
R3527 T14022 T14023 det the,data
R3528 T14023 T14021 nsubj data,provide
R3529 T14024 T14023 amod published,data
R3530 T14067 T14068 compound μ,calpain
R3531 T14025 T14023 punct ", ",data
R3532 T14026 T14023 prep owing,data
R3533 T14027 T14026 prep to,owing
R3534 T14068 T14070 compound calpain,deficiency
R3535 T14028 T14027 pobj weaknesses,to
R3536 T14029 T14028 prep in,weaknesses
R3537 T14030 T14031 det the,methodology
R3538 T14069 T14068 punct -,calpain
R3539 T14031 T14029 pobj methodology,in
R3540 T14032 T14031 amod available,methodology
R3541 T14033 T14021 punct ", ",provide
R3542 T14070 T14066 pobj deficiency,for
R3543 T14034 T14021 aux do,provide
R3544 T14035 T14021 neg not,provide
R3545 T14036 T14037 amod reliable,estimates
R3546 T14071 T14064 prep by,Compensation
R3547 T14037 T14021 dobj estimates,provide
R3548 T14038 T14037 prep of,estimates
R3549 T14039 T14040 poss their,amounts
R3550 T14072 T14073 compound m,calpain
R3551 T14040 T14038 pobj amounts,of
R3552 T14073 T14071 pobj calpain,by
R3553 T14074 T14073 punct -,calpain
R3554 T14075 T14065 advmod therefore,is
R3555 T14147 T14145 punct -,Capn2
R3556 T14076 T14077 advmod less,likely
R3557 T14148 T14145 punct /,Capn2
R3558 T14149 T14145 punct -,Capn2
R3559 T14077 T14065 acomp likely,is
R3560 T14150 T14151 mark that,is
R3561 T14151 T14140 ccomp is,demonstrates
R3562 T14078 T14077 prep in,likely
R3563 T14152 T14153 compound m,calpain
R3564 T14153 T14155 compound calpain,activity
R3565 T14154 T14153 punct -,calpain
R3566 T14079 T14078 pobj platelets,in
R3567 T14155 T14151 nsubj activity,is
R3568 T14156 T14151 acomp essential,is
R3569 T14157 T14156 prep for,essential
R3570 T14080 T14079 cc and,platelets
R3571 T14158 T14159 amod embryonic,development
R3572 T14159 T14157 pobj development,for
R3573 T14160 T14159 prep beyond,development
R3574 T14081 T14079 conj erythrocytes,platelets
R3575 T14161 T14162 det the,stage
R3576 T14162 T14160 pobj stage,beyond
R3577 T14082 T14077 prep than,likely
R3578 T14163 T14164 nummod 8,cell
R3579 T14164 T14162 compound cell,stage
R3580 T14165 T14164 punct -,cell
R3581 T14083 T14082 prep in,than
R3582 T14166 T14140 punct .,demonstrates
R3583 T14168 T14169 nsubj It,follows
R3584 T14084 T14085 amod other,types
R3585 T14170 T14171 mark that,are
R3586 T14171 T14169 ccomp are,follows
R3587 T14085 T14083 pobj types,in
R3588 T14172 T14173 advmod at,least
R3589 T14173 T14174 advmod least,functions
R3590 T14086 T14085 compound cell,types
R3591 T14174 T14171 nsubj functions,are
R3592 T14175 T14174 det some,functions
R3593 T14176 T14174 prep of,functions
R3594 T14087 T14065 punct .,is
R3595 T14177 T14178 compound μ,calpain
R3596 T14178 T14176 pobj calpain,of
R3597 T14179 T14178 punct -,calpain
R3598 T14089 T14090 prep As,is
R3599 T14180 T14178 cc and,calpain
R3600 T14181 T14182 compound m,calpain
R3601 T14182 T14178 conj calpain,calpain
R3602 T14183 T14182 punct -,calpain
R3603 T14184 T14171 acomp distinct,are
R3604 T14185 T14169 punct .,follows
R3605 T14091 T14092 det a,result
R3607 T14092 T14089 pobj result,As
R3610 T14093 T14090 punct ", ",is
R3614 T14094 T14090 nsubj it,is
R3618 T14095 T14090 neg not,is
R3621 T14096 T14090 acomp possible,is
R3625 T14097 T14098 aux to,determine
R3629 T14098 T14090 xcomp determine,is
R3631 T14099 T14100 mark whether,is
R3635 T14100 T14098 advcl is,determine
R3638 T14101 T14102 det the,absence
R3642 T14102 T14100 nsubj absence,is
R3646 T14103 T14102 prep of,absence
R3650 T14104 T14105 amod marked,phenotype
R3653 T14105 T14103 pobj phenotype,of
R3658 T14106 T14102 prep in,absence
R3662 T14107 T14108 nmod Capn1,animals
R3666 T14108 T14106 pobj animals,in
R3670 T14109 T14107 punct -,Capn1
R3674 T14110 T14107 punct /,Capn1
R3678 T14111 T14107 punct -,Capn1
R3682 T14112 T14100 prep due,is
R3685 T14113 T14112 pcomp to,due
R3689 T14114 T14115 det a,affect
R3690 T14115 T14112 pobj affect,due
R3691 T14116 T14115 amod compensatory,affect
R3693 T14117 T14115 prep by,affect
R3696 T14118 T14119 det the,activity
R3699 T14119 T14117 pobj activity,by
R3702 T14120 T14119 amod remaining,activity
R3709 T14121 T14122 compound m,calpain
R3712 T14122 T14119 compound calpain,activity
R3715 T14123 T14122 punct -,calpain
R3718 T14124 T14100 punct ", ",is
R3722 T14125 T14100 cc or,is
R3723 T14126 T14127 mark whether,are
R3725 T14127 T14100 conj are,is
R3729 T14128 T14129 det the,functions
R3733 T14129 T14127 nsubj functions,are
R3736 T14130 T14129 prep of,functions
R3739 T14131 T14132 compound μ,calpain
R3743 T14132 T14130 pobj calpain,of
R3746 T14133 T14132 punct -,calpain
R3749 T14134 T14127 advmod simply,are
R3752 T14135 T14127 neg not,are
R3756 T14136 T14127 acomp essential,are
R3762 T14137 T14090 punct .,is
R3766 T14139 T14140 prep In,demonstrates
R3771 T14141 T14139 pobj contrast,In
R3774 T14142 T14140 punct ", ",demonstrates
R3778 T14143 T14140 nsubj lethality,demonstrates
R3781 T14144 T14143 prep in,lethality
R3785 T14145 T14146 nmod Capn2,embryos
R3788 T14146 T14144 pobj embryos,in

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12315 1939-1951 UBERON:0019252 denotes 8-cell stage
T12314 1906-1927 GO:0009790 denotes embryonic development
T12313 1906-1915 UBERON:0000922 denotes embryonic
T12312 1844-1851 UBERON:0000922 denotes embryos
T12311 1835-1840 PR:000005015 denotes Capn2
T12310 1668-1675 NCBITaxon:33208 denotes animals
T12309 1659-1664 PR:000005009 denotes Capn1
T12308 1532-1544 CL:0000232 denotes erythrocytes
T12307 1518-1527 CL:0000233 denotes platelets
T12306 1342-1354 CL:0000232 denotes erythrocytes
T12305 1328-1337 CL:0000233 denotes Platelets
T12304 1171-1180 NCBITaxon:40674 denotes mammalian
T12303 1097-1116 GO:0030168 denotes platelet activation
T12302 1097-1105 CL:0000233 denotes platelet
T12301 1076-1084 GO:0006468 denotes proteins
T12300 1049-1067 _FRAGMENT denotes phosphorylation of
T12299 992-1000 CL:0000233 denotes platelet
T12298 949-954 PR:000005009 denotes Capn1
T12297 890-894 NCBITaxon:10088 denotes mice
T12296 851-856 PR:000005009 denotes Capn1
T12295 845-849 SO:0000704 denotes gene
T12294 821-844 PR:000005009 denotes μ-calpain large subunit
T12293 778-790 GO:0007566 denotes implantation
T12292 765-768 GO:0016265 denotes die
T12291 757-764 UBERON:0000922 denotes embryos
T12290 750-756 NCBITaxon:39107 denotes murine
T12289 739-744 PR:000005015 denotes Capn2
T12288 706-719 GO:0009790 denotes embryogenesis
T12287 622-626 NCBITaxon:10088 denotes mice
T12286 594-598 SO:0000704 denotes gene
T12285 544-553 GO:0065007 denotes regulated
T12284 516-524 SO:0001060 denotes isoforms
T12283 458-462 CHEBI:29108 denotes Ca2+
T12282 262-268 MOP:0000780 denotes cleave
T12281 86-94 SO:0001060 denotes isoforms
R2359 T12301 T12300 _lexicallyChainedTo proteins,phosphorylation of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12625 2010-2019 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12624 1998-2005 GO_PR_EXT:calpain_1_complex denotes calpain
T12623 1996-2005 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T12622 1941-1945 CL_GO_EXT:cell denotes cell
T12621 1939-1951 UBERON:0019252 denotes 8-cell stage
T12620 1906-1927 GO:0009790 denotes embryonic development
T12619 1906-1915 UBERON:0000922 denotes embryonic
T12618 1870-1879 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12617 1844-1851 UBERON:0000922 denotes embryos
T12616 1842-1843 SO_EXT:sequence_nullness_or_absence denotes -
T12615 1840-1841 SO_EXT:sequence_nullness_or_absence denotes -
T12614 1835-1840 PR_EXT:000005015 denotes Capn2
T12613 1822-1831 GO_EXT:fatality_or_lethality denotes lethality
T12612 1773-1782 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T12611 1725-1734 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12610 1668-1675 NCBITaxon:33208 denotes animals
T12609 1666-1667 SO_EXT:sequence_nullness_or_absence denotes -
T12608 1664-1665 SO_EXT:sequence_nullness_or_absence denotes -
T12607 1659-1664 PR_EXT:000005009 denotes Capn1
T12606 1559-1563 CL_GO_EXT:cell denotes cell
T12605 1532-1544 CL:0000232 denotes erythrocytes
T12604 1518-1527 CL:0000233 denotes platelets
T12603 1480-1489 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12602 1456-1465 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T12601 1398-1407 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12600 1372-1381 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T12599 1342-1354 CL:0000232 denotes erythrocytes
T12598 1328-1337 CL:0000233 denotes Platelets
T12597 1181-1186 CL_GO_EXT:cell denotes cells
T12596 1171-1180 NCBITaxon:40674 denotes mammalian
T12595 1130-1139 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12594 1132-1139 GO_PR_EXT:calpain_1_complex denotes calpain
T12593 1123-1125 _FRAGMENT denotes μ-
T12592 1097-1116 GO:0030168 denotes platelet activation
T12591 1097-1105 CL:0000233 denotes platelet
T12590 1076-1084 CHEBI_PR_EXT:protein denotes proteins
T12589 1076-1084 GO:0006468 denotes proteins
T12588 1049-1067 _FRAGMENT denotes phosphorylation of
T12587 1040-1048 CHEBI_SO_EXT:tyrosine denotes tyrosine
T12586 992-1000 CL:0000233 denotes platelet
T12585 949-954 PR_EXT:000005009 denotes Capn1
T12584 890-894 NCBITaxon:10088 denotes mice
T12583 851-856 PR_EXT:000005009 denotes Capn1
T12582 845-849 SO_EXT:0000704 denotes gene
T12581 823-830 GO_PR_EXT:calpain_1_complex denotes calpain
T12580 821-844 PR_EXT:000005009 denotes μ-calpain large subunit
T12579 778-790 GO:0007566 denotes implantation
T12578 765-768 GO:0016265 denotes die
T12577 757-764 UBERON:0000922 denotes embryos
T12576 750-756 NCBITaxon:39107 denotes murine
T12575 745-749 SO_EXT:sequence_nullness denotes null
T12574 739-744 PR_EXT:000005015 denotes Capn2
T12573 706-719 GO:0009790 denotes embryogenesis
T12572 669-682 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T12571 640-649 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12570 642-649 GO_PR_EXT:calpain_1_complex denotes calpain
T12569 633-635 _FRAGMENT denotes μ-
T12568 622-626 NCBITaxon:10088 denotes mice
T12567 594-598 SO_EXT:0000704 denotes gene
T12566 561-566 CL_GO_EXT:cell denotes cells
T12565 544-553 GO:0065007 denotes regulated
T12564 516-524 SO_EXT:0001060 denotes isoforms
T12563 458-462 CHEBI:29108 denotes Ca2+
T12562 262-268 MOP:0000780 denotes cleave
T12561 172-180 SO_EXT:biological_sequence denotes sequence
T12560 154-161 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T12559 103-112 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12558 105-112 GO_PR_EXT:calpain_1_complex denotes calpain
T12557 96-98 _FRAGMENT denotes μ-
T12556 86-94 SO_EXT:0001060 denotes isoforms
R2363 T12558 T12557 _lexicallyChainedTo calpain,μ-
R2365 T12570 T12569 _lexicallyChainedTo calpain,μ-
R2366 T12589 T12588 _lexicallyChainedTo proteins,phosphorylation of
R2367 T12594 T12593 _lexicallyChainedTo calpain,μ-