Id |
Subject |
Object |
Predicate |
Lexical cue |
T14185 |
2032-2033 |
. |
denotes |
. |
T14184 |
2024-2032 |
JJ |
denotes |
distinct |
T14183 |
2011-2012 |
HYPH |
denotes |
- |
T14182 |
2012-2019 |
NN |
denotes |
calpain |
T14181 |
2010-2011 |
NN |
denotes |
m |
T14180 |
2006-2009 |
CC |
denotes |
and |
T14179 |
1997-1998 |
HYPH |
denotes |
- |
T14178 |
1998-2005 |
NN |
denotes |
calpain |
T14177 |
1996-1997 |
NN |
denotes |
μ |
T14176 |
1993-1995 |
IN |
denotes |
of |
T14175 |
1978-1982 |
DT |
denotes |
some |
T14174 |
1983-1992 |
NNS |
denotes |
functions |
T14173 |
1972-1977 |
RBS |
denotes |
least |
T14172 |
1969-1971 |
RB |
denotes |
at |
T14171 |
2020-2023 |
VBP |
denotes |
are |
T14170 |
1964-1968 |
IN |
denotes |
that |
T14169 |
1956-1963 |
VBZ |
denotes |
follows |
T14168 |
1953-1955 |
PRP |
denotes |
It |
T14167 |
1952-2033 |
sentence |
denotes |
It follows that at least some functions of μ-calpain and m-calpain are distinct. |
T14166 |
1951-1952 |
. |
denotes |
. |
T14165 |
1940-1941 |
HYPH |
denotes |
- |
T14164 |
1941-1945 |
NN |
denotes |
cell |
T14163 |
1939-1940 |
CD |
denotes |
8 |
T14162 |
1946-1951 |
NN |
denotes |
stage |
T14161 |
1935-1938 |
DT |
denotes |
the |
T14040 |
1319-1326 |
NNS |
denotes |
amounts |
T14039 |
1304-1309 |
PRP$ |
denotes |
their |
T14038 |
1301-1303 |
IN |
denotes |
of |
T14037 |
1291-1300 |
NNS |
denotes |
estimates |
T14036 |
1282-1290 |
JJ |
denotes |
reliable |
T14035 |
1270-1273 |
RB |
denotes |
not |
T14034 |
1267-1269 |
VBP |
denotes |
do |
T14033 |
1265-1267 |
, |
denotes |
, |
T14032 |
1244-1253 |
JJ |
denotes |
available |
T14031 |
1254-1265 |
NN |
denotes |
methodology |
T14030 |
1240-1243 |
DT |
denotes |
the |
T14029 |
1237-1239 |
IN |
denotes |
in |
T14028 |
1226-1236 |
NNS |
denotes |
weaknesses |
T14027 |
1223-1225 |
IN |
denotes |
to |
T14026 |
1217-1222 |
VBG |
denotes |
owing |
T14025 |
1215-1217 |
, |
denotes |
, |
T14024 |
1201-1210 |
VBN |
denotes |
published |
T14023 |
1211-1215 |
NNS |
denotes |
data |
T14022 |
1197-1200 |
DT |
denotes |
the |
T14021 |
1274-1281 |
VB |
denotes |
provide |
T14020 |
1188-1196 |
IN |
denotes |
although |
T14019 |
1186-1188 |
, |
denotes |
, |
T14018 |
1171-1180 |
JJ |
denotes |
mammalian |
T14017 |
1181-1186 |
NNS |
denotes |
cells |
T14016 |
1166-1170 |
JJS |
denotes |
most |
T14015 |
1163-1165 |
IN |
denotes |
in |
T14014 |
1155-1162 |
JJ |
denotes |
present |
T14013 |
1151-1154 |
VBP |
denotes |
are |
T14012 |
1131-1132 |
HYPH |
denotes |
- |
T14011 |
1130-1131 |
NN |
denotes |
m |
T14010 |
1126-1129 |
CC |
denotes |
and |
T14009 |
1124-1125 |
HYPH |
denotes |
- |
T14008 |
1132-1139 |
NN |
denotes |
calpain |
T14007 |
1123-1124 |
NN |
denotes |
μ |
T14006 |
1140-1150 |
NNS |
denotes |
activities |
T14005 |
1118-1122 |
CC |
denotes |
Both |
T14004 |
1117-1327 |
sentence |
denotes |
Both μ- and m-calpain activities are present in most mammalian cells, although the published data, owing to weaknesses in the available methodology, do not provide reliable estimates of their relative amounts. |
T14003 |
1116-1117 |
. |
denotes |
. |
T14002 |
1106-1116 |
NN |
denotes |
activation |
T14001 |
1097-1105 |
NN |
denotes |
platelet |
T14000 |
1094-1096 |
IN |
denotes |
in |
T13999 |
1085-1093 |
VBN |
denotes |
involved |
T13998 |
1076-1084 |
NN |
denotes |
proteins |
T13997 |
1068-1075 |
JJ |
denotes |
certain |
T13996 |
1065-1067 |
IN |
denotes |
of |
T13995 |
1040-1048 |
NN |
denotes |
tyrosine |
T13994 |
1049-1064 |
NN |
denotes |
phosphorylation |
T13993 |
1036-1039 |
DT |
denotes |
the |
T13992 |
1033-1035 |
IN |
denotes |
of |
T13991 |
1027-1032 |
NN |
denotes |
level |
T13990 |
1023-1026 |
DT |
denotes |
the |
T13989 |
1020-1022 |
IN |
denotes |
at |
T13988 |
1011-1019 |
RB |
denotes |
possibly |
T13987 |
1009-1011 |
, |
denotes |
, |
T13986 |
1001-1009 |
NN |
denotes |
function |
T13985 |
992-1000 |
NN |
denotes |
platelet |
T13984 |
989-991 |
IN |
denotes |
in |
T13983 |
977-988 |
NN |
denotes |
disturbance |
T13982 |
975-976 |
DT |
denotes |
a |
T13981 |
955-965 |
NN |
denotes |
deficiency |
T13980 |
949-954 |
NN |
denotes |
Capn1 |
T13979 |
946-948 |
IN |
denotes |
of |
T13978 |
939-945 |
NN |
denotes |
result |
T13977 |
937-938 |
DT |
denotes |
a |
T13976 |
934-936 |
IN |
denotes |
as |
T13975 |
925-933 |
VBN |
denotes |
observed |
T13974 |
966-974 |
VBD |
denotes |
involved |
T13973 |
905-914 |
JJ |
denotes |
principal |
T13972 |
915-924 |
NN |
denotes |
phenotype |
T13971 |
901-904 |
DT |
denotes |
The |
T13970 |
900-1117 |
sentence |
denotes |
The principal phenotype observed as a result of Capn1 deficiency involved a disturbance in platelet function, possibly at the level of the tyrosine phosphorylation of certain proteins involved in platelet activation. |
T13969 |
899-900 |
. |
denotes |
. |
T13968 |
898-899 |
-RRB- |
denotes |
] |
T13967 |
896-898 |
CD |
denotes |
33 |
T13966 |
895-896 |
-LRB- |
denotes |
[ |
T13965 |
890-894 |
NNS |
denotes |
mice |
T13964 |
887-889 |
IN |
denotes |
of |
T13963 |
877-886 |
NN |
denotes |
viability |
T13962 |
873-876 |
DT |
denotes |
the |
T13961 |
862-865 |
RB |
denotes |
not |
T13960 |
858-861 |
VBD |
denotes |
did |
T13959 |
856-858 |
, |
denotes |
, |
T13958 |
851-856 |
NN |
denotes |
Capn1 |
T13957 |
849-851 |
, |
denotes |
, |
T13956 |
837-844 |
NN |
denotes |
subunit |
T13955 |
831-836 |
JJ |
denotes |
large |
T13954 |
822-823 |
HYPH |
denotes |
- |
T13953 |
823-830 |
NN |
denotes |
calpain |
T13952 |
821-822 |
NN |
denotes |
μ |
T13951 |
845-849 |
NN |
denotes |
gene |
T13950 |
817-820 |
DT |
denotes |
the |
T13949 |
814-816 |
IN |
denotes |
of |
T13948 |
803-813 |
NN |
denotes |
disruption |
T13947 |
792-802 |
JJ |
denotes |
homozygous |
T13946 |
790-792 |
, |
denotes |
, |
T13945 |
778-790 |
NN |
denotes |
implantation |
T13944 |
775-777 |
IN |
denotes |
to |
T13943 |
769-774 |
JJ |
denotes |
prior |
T13942 |
750-756 |
JJ |
denotes |
murine |
T13941 |
757-764 |
NNS |
denotes |
embryos |
T13940 |
745-749 |
JJ |
denotes |
null |
T13939 |
739-744 |
NN |
denotes |
Capn2 |
T13938 |
765-768 |
VBP |
denotes |
die |
T13937 |
731-738 |
IN |
denotes |
whereas |
T13936 |
729-731 |
, |
denotes |
, |
T13935 |
866-872 |
VB |
denotes |
affect |
T13934 |
724-729 |
VBN |
denotes |
noted |
T13933 |
721-723 |
IN |
denotes |
As |
T13932 |
720-900 |
sentence |
denotes |
As noted, whereas Capn2 null murine embryos die prior to implantation, homozygous disruption of the μ-calpain large subunit gene, Capn1, did not affect the viability of mice [33]. |
T13931 |
719-720 |
. |
denotes |
. |
T13930 |
706-719 |
NN |
denotes |
embryogenesis |
T13929 |
699-705 |
IN |
denotes |
during |
T13928 |
693-698 |
RBS |
denotes |
least |
T13927 |
690-692 |
RB |
denotes |
at |
T13926 |
688-690 |
, |
denotes |
, |
T13925 |
669-682 |
JJ |
denotes |
physiological |
T13924 |
660-668 |
JJ |
denotes |
distinct |
T13923 |
683-688 |
NNS |
denotes |
roles |
T13922 |
655-659 |
DT |
denotes |
some |
T13921 |
641-642 |
HYPH |
denotes |
- |
T13920 |
640-641 |
NN |
denotes |
m |
T13919 |
636-639 |
CC |
denotes |
and |
T13918 |
634-635 |
HYPH |
denotes |
- |
T13917 |
642-649 |
NN |
denotes |
calpain |
T13916 |
633-634 |
NN |
denotes |
μ |
T13915 |
650-654 |
VBP |
denotes |
have |
T13914 |
628-632 |
IN |
denotes |
that |
T13913 |
626-628 |
, |
denotes |
, |
T13912 |
622-626 |
NNS |
denotes |
mice |
T13911 |
619-621 |
IN |
denotes |
in |
T13910 |
614-618 |
VBN |
denotes |
done |
T13909 |
599-608 |
NN |
denotes |
targeting |
T13908 |
594-598 |
NN |
denotes |
gene |
T13907 |
609-613 |
NN |
denotes |
work |
T13906 |
590-593 |
DT |
denotes |
the |
T13905 |
585-589 |
IN |
denotes |
from |
T13904 |
583-585 |
, |
denotes |
, |
T13903 |
578-583 |
JJ |
denotes |
clear |
T13902 |
574-577 |
RB |
denotes |
now |
T13901 |
571-573 |
VBZ |
denotes |
is |
T13900 |
568-570 |
PRP |
denotes |
It |
T13899 |
567-720 |
sentence |
denotes |
It is now clear, from the gene targeting work done in mice, that μ- and m-calpain have some distinct physiological roles, at least during embryogenesis. |
T13898 |
566-567 |
. |
denotes |
. |
T13897 |
561-566 |
NNS |
denotes |
cells |
T13896 |
554-560 |
IN |
denotes |
inside |
T13895 |
529-543 |
RB |
denotes |
differentially |
T13894 |
525-528 |
VBP |
denotes |
are |
T13893 |
512-515 |
CD |
denotes |
two |
T13892 |
516-524 |
NNS |
denotes |
isoforms |
T13891 |
508-511 |
DT |
denotes |
the |
T13890 |
544-553 |
VBN |
denotes |
regulated |
T13889 |
503-507 |
IN |
denotes |
that |
T13888 |
494-502 |
JJ |
denotes |
possible |
T13887 |
488-490 |
PRP |
denotes |
it |
T13886 |
486-488 |
, |
denotes |
, |
T13885 |
476-486 |
NN |
denotes |
activation |
T13884 |
470-475 |
FW |
denotes |
vitro |
T13883 |
467-469 |
FW |
denotes |
in |
T13882 |
463-466 |
IN |
denotes |
for |
T13881 |
461-462 |
SYM |
denotes |
+ |
T13880 |
458-461 |
NN |
denotes |
Ca2 |
T13879 |
455-457 |
IN |
denotes |
of |
T13878 |
447-454 |
NNS |
denotes |
amounts |
T13877 |
437-446 |
JJ |
denotes |
different |
T13876 |
424-428 |
PRP |
denotes |
they |
T13875 |
429-436 |
VBP |
denotes |
require |
T13874 |
418-423 |
IN |
denotes |
since |
T13873 |
416-418 |
, |
denotes |
, |
T13872 |
406-411 |
JJ |
denotes |
other |
T13871 |
412-416 |
NN |
denotes |
hand |
T13870 |
402-405 |
DT |
denotes |
the |
T13869 |
491-493 |
VBZ |
denotes |
is |
T13868 |
399-401 |
IN |
denotes |
On |
T13867 |
398-567 |
sentence |
denotes |
On the other hand, since they require different amounts of Ca2+ for in vitro activation, it is possible that the two isoforms are differentially regulated inside cells. |
T13866 |
397-398 |
. |
denotes |
. |
T13865 |
393-397 |
FW |
denotes |
vivo |
T13864 |
390-392 |
FW |
denotes |
in |
T13863 |
375-379 |
JJ |
denotes |
same |
T13862 |
380-389 |
NNS |
denotes |
functions |
T13861 |
371-374 |
DT |
denotes |
the |
T13860 |
367-370 |
RP |
denotes |
out |
T13859 |
361-366 |
VB |
denotes |
carry |
T13858 |
358-360 |
TO |
denotes |
to |
T13857 |
348-357 |
NN |
denotes |
potential |
T13856 |
344-347 |
DT |
denotes |
the |
T13855 |
334-338 |
PRP |
denotes |
they |
T13854 |
339-343 |
VBP |
denotes |
have |
T13853 |
329-333 |
IN |
denotes |
that |
T13852 |
318-328 |
VBG |
denotes |
suggesting |
T13851 |
316-318 |
, |
denotes |
, |
T13850 |
311-316 |
FW |
denotes |
vitro |
T13849 |
308-310 |
FW |
denotes |
in |
T13848 |
297-307 |
NNS |
denotes |
substrates |
T13847 |
294-296 |
IN |
denotes |
of |
T13846 |
285-289 |
JJ |
denotes |
same |
T13845 |
290-293 |
NN |
denotes |
set |
T13844 |
281-284 |
DT |
denotes |
the |
T13843 |
269-280 |
RB |
denotes |
essentially |
T13842 |
257-261 |
PRP |
denotes |
they |
T13841 |
255-257 |
, |
denotes |
, |
T13840 |
262-268 |
VBP |
denotes |
cleave |
T13839 |
248-255 |
RB |
denotes |
Notably |
T13838 |
247-398 |
sentence |
denotes |
Notably, they cleave essentially the same set of substrates in vitro, suggesting that they have the potential to carry out the same functions in vivo. |
T13837 |
246-247 |
. |
denotes |
. |
T13836 |
234-246 |
NN |
denotes |
biochemistry |
T13835 |
230-233 |
CC |
denotes |
and |
T13834 |
220-229 |
NN |
denotes |
structure |
T13833 |
214-219 |
PRP$ |
denotes |
their |
T13832 |
211-213 |
IN |
denotes |
in |
T13831 |
203-210 |
JJ |
denotes |
similar |
T13830 |
198-202 |
RB |
denotes |
very |
T13829 |
194-197 |
VBP |
denotes |
are |
T13828 |
190-193 |
CC |
denotes |
and |
T13827 |
172-180 |
NN |
denotes |
sequence |
T13826 |
181-189 |
NN |
denotes |
identity |
T13825 |
170-171 |
NN |
denotes |
% |
T14160 |
1928-1934 |
IN |
denotes |
beyond |
T14159 |
1916-1927 |
NN |
denotes |
development |
T14158 |
1906-1915 |
JJ |
denotes |
embryonic |
T14157 |
1902-1905 |
IN |
denotes |
for |
T14156 |
1892-1901 |
JJ |
denotes |
essential |
T14155 |
1880-1888 |
NN |
denotes |
activity |
T14154 |
1871-1872 |
HYPH |
denotes |
- |
T14153 |
1872-1879 |
NN |
denotes |
calpain |
T14152 |
1870-1871 |
NN |
denotes |
m |
T14151 |
1889-1891 |
VBZ |
denotes |
is |
T14150 |
1865-1869 |
IN |
denotes |
that |
T14149 |
1842-1843 |
SYM |
denotes |
- |
T14148 |
1841-1842 |
HYPH |
denotes |
/ |
T14147 |
1840-1841 |
SYM |
denotes |
- |
T14146 |
1844-1851 |
NNS |
denotes |
embryos |
T14145 |
1835-1840 |
NN |
denotes |
Capn2 |
T14144 |
1832-1834 |
IN |
denotes |
in |
T14143 |
1822-1831 |
NN |
denotes |
lethality |
T14142 |
1820-1822 |
, |
denotes |
, |
T14141 |
1812-1820 |
NN |
denotes |
contrast |
T14140 |
1852-1864 |
VBZ |
denotes |
demonstrates |
T14139 |
1809-1811 |
IN |
denotes |
In |
T14138 |
1808-1952 |
sentence |
denotes |
In contrast, lethality in Capn2-/- embryos demonstrates that m-calpain activity is essential for embryonic development beyond the 8-cell stage. |
T14137 |
1807-1808 |
. |
denotes |
. |
T14136 |
1798-1807 |
JJ |
denotes |
essential |
T14135 |
1794-1797 |
RB |
denotes |
not |
T14134 |
1787-1793 |
RB |
denotes |
simply |
T14133 |
1774-1775 |
HYPH |
denotes |
- |
T14132 |
1775-1782 |
NN |
denotes |
calpain |
T14131 |
1773-1774 |
NN |
denotes |
μ |
T14130 |
1770-1772 |
IN |
denotes |
of |
T14129 |
1760-1769 |
NNS |
denotes |
functions |
T14128 |
1756-1759 |
DT |
denotes |
the |
T14127 |
1783-1786 |
VBP |
denotes |
are |
T14126 |
1748-1755 |
IN |
denotes |
whether |
T14125 |
1745-1747 |
CC |
denotes |
or |
T14124 |
1743-1745 |
, |
denotes |
, |
T14123 |
1726-1727 |
HYPH |
denotes |
- |
T14122 |
1727-1734 |
NN |
denotes |
calpain |
T14121 |
1725-1726 |
NN |
denotes |
m |
T14120 |
1715-1724 |
VBG |
denotes |
remaining |
T14119 |
1735-1743 |
NN |
denotes |
activity |
T14118 |
1711-1714 |
DT |
denotes |
the |
T14117 |
1708-1710 |
IN |
denotes |
by |
T14116 |
1688-1700 |
JJ |
denotes |
compensatory |
T14115 |
1701-1707 |
NN |
denotes |
affect |
T14114 |
1686-1687 |
DT |
denotes |
a |
T14113 |
1683-1685 |
IN |
denotes |
to |
T14112 |
1679-1682 |
IN |
denotes |
due |
T14111 |
1666-1667 |
SYM |
denotes |
- |
T14110 |
1665-1666 |
HYPH |
denotes |
/ |
T14109 |
1664-1665 |
SYM |
denotes |
- |
T14108 |
1668-1675 |
NNS |
denotes |
animals |
T14107 |
1659-1664 |
NN |
denotes |
Capn1 |
T14106 |
1656-1658 |
IN |
denotes |
in |
T14105 |
1646-1655 |
NN |
denotes |
phenotype |
T14104 |
1639-1645 |
JJ |
denotes |
marked |
T14103 |
1636-1638 |
IN |
denotes |
of |
T14102 |
1628-1635 |
NN |
denotes |
absence |
T14101 |
1624-1627 |
DT |
denotes |
the |
T14100 |
1676-1678 |
VBZ |
denotes |
is |
T14099 |
1616-1623 |
IN |
denotes |
whether |
T14098 |
1606-1615 |
VB |
denotes |
determine |
T14097 |
1603-1605 |
TO |
denotes |
to |
T14096 |
1594-1602 |
JJ |
denotes |
possible |
T14095 |
1590-1593 |
RB |
denotes |
not |
T14094 |
1584-1586 |
PRP |
denotes |
it |
T14093 |
1582-1584 |
, |
denotes |
, |
T14092 |
1576-1582 |
NN |
denotes |
result |
T14091 |
1574-1575 |
DT |
denotes |
a |
T14090 |
1587-1589 |
VBZ |
denotes |
is |
T14089 |
1571-1573 |
IN |
denotes |
As |
T14088 |
1570-1808 |
sentence |
denotes |
As a result, it is not possible to determine whether the absence of marked phenotype in Capn1-/- animals is due to a compensatory affect by the remaining m-calpain activity, or whether the functions of μ-calpain are simply not essential. |
T14087 |
1569-1570 |
. |
denotes |
. |
T14086 |
1559-1563 |
NN |
denotes |
cell |
T14085 |
1564-1569 |
NNS |
denotes |
types |
T14084 |
1553-1558 |
JJ |
denotes |
other |
T14083 |
1550-1552 |
IN |
denotes |
in |
T14082 |
1545-1549 |
IN |
denotes |
than |
T14081 |
1532-1544 |
NNS |
denotes |
erythrocytes |
T14080 |
1528-1531 |
CC |
denotes |
and |
T14079 |
1518-1527 |
NNS |
denotes |
platelets |
T14078 |
1515-1517 |
IN |
denotes |
in |
T14077 |
1508-1514 |
JJ |
denotes |
likely |
T14076 |
1503-1507 |
RBR |
denotes |
less |
T14075 |
1493-1502 |
RB |
denotes |
therefore |
T14074 |
1481-1482 |
HYPH |
denotes |
- |
T14073 |
1482-1489 |
NN |
denotes |
calpain |
T14072 |
1480-1481 |
NN |
denotes |
m |
T14071 |
1477-1479 |
IN |
denotes |
by |
T14070 |
1466-1476 |
NN |
denotes |
deficiency |
T14069 |
1457-1458 |
HYPH |
denotes |
- |
T14068 |
1458-1465 |
NN |
denotes |
calpain |
T14067 |
1456-1457 |
NN |
denotes |
μ |
T14066 |
1452-1455 |
IN |
denotes |
for |
T14065 |
1490-1492 |
VBZ |
denotes |
is |
T14064 |
1439-1451 |
NN |
denotes |
Compensation |
T14063 |
1438-1570 |
sentence |
denotes |
Compensation for μ-calpain deficiency by m-calpain is therefore less likely in platelets and erythrocytes than in other cell types. |
T14062 |
1437-1438 |
. |
denotes |
. |
T14061 |
1427-1437 |
JJ |
denotes |
detectable |
T14060 |
1420-1426 |
RB |
denotes |
barely |
T14059 |
1408-1416 |
NN |
denotes |
activity |
T14058 |
1399-1400 |
HYPH |
denotes |
- |
T14057 |
1400-1407 |
NN |
denotes |
calpain |
T14056 |
1398-1399 |
NN |
denotes |
m |
T14055 |
1417-1419 |
VBZ |
denotes |
is |
T14054 |
1392-1397 |
IN |
denotes |
while |
T14053 |
1390-1392 |
, |
denotes |
, |
T14052 |
1373-1374 |
HYPH |
denotes |
- |
T14051 |
1374-1381 |
NN |
denotes |
calpain |
T14050 |
1372-1373 |
NN |
denotes |
μ |
T14049 |
1382-1390 |
NN |
denotes |
activity |
T14048 |
1363-1371 |
JJ |
denotes |
abundant |
T14047 |
1342-1354 |
NNS |
denotes |
erythrocytes |
T14046 |
1338-1341 |
CC |
denotes |
and |
T14045 |
1355-1362 |
VBP |
denotes |
contain |
T14044 |
1328-1337 |
NNS |
denotes |
Platelets |
T14043 |
1327-1438 |
sentence |
denotes |
Platelets and erythrocytes contain abundant μ-calpain activity, while m-calpain activity is barely detectable. |
T14042 |
1326-1327 |
. |
denotes |
. |
T14041 |
1310-1318 |
JJ |
denotes |
relative |
T13824 |
168-170 |
CD |
denotes |
62 |
T13823 |
162-167 |
VBP |
denotes |
share |
T13822 |
150-153 |
CD |
denotes |
two |
T13821 |
154-161 |
NNS |
denotes |
enzymes |
T13820 |
146-149 |
DT |
denotes |
The |
T13819 |
145-247 |
sentence |
denotes |
The two enzymes share 62% sequence identity and are very similar in their structure and biochemistry. |
T13818 |
144-145 |
. |
denotes |
. |
T13817 |
134-138 |
FW |
denotes |
vivo |
T13816 |
131-133 |
FW |
denotes |
in |
T13815 |
139-144 |
NNS |
denotes |
roles |
T13814 |
122-130 |
JJ |
denotes |
distinct |
T13813 |
112-114 |
, |
denotes |
, |
T13812 |
104-105 |
HYPH |
denotes |
- |
T13811 |
103-104 |
NN |
denotes |
m |
T13810 |
99-102 |
CC |
denotes |
and |
T13809 |
97-98 |
HYPH |
denotes |
- |
T13808 |
105-112 |
NN |
denotes |
calpain |
T13807 |
96-97 |
NN |
denotes |
μ |
T13806 |
94-96 |
, |
denotes |
, |
T13805 |
75-85 |
JJ |
denotes |
ubiquitous |
T13804 |
71-74 |
CD |
denotes |
two |
T13803 |
86-94 |
NNS |
denotes |
isoforms |
T13802 |
67-70 |
DT |
denotes |
the |
T13801 |
114-121 |
VBP |
denotes |
possess |
T13800 |
59-66 |
IN |
denotes |
whether |
T13799 |
50-53 |
VBZ |
denotes |
has |
T13798 |
41-49 |
NN |
denotes |
research |
T13797 |
33-40 |
NN |
denotes |
calpain |
T13796 |
30-32 |
IN |
denotes |
in |
T13795 |
11-19 |
VBG |
denotes |
enduring |
T13794 |
20-29 |
NNS |
denotes |
questions |
T13793 |
7-10 |
DT |
denotes |
the |
T13792 |
4-6 |
IN |
denotes |
of |
T13791 |
54-58 |
VBN |
denotes |
been |
T13790 |
0-3 |
CD |
denotes |
One |
R3221 |
T13790 |
T13791 |
nsubj |
One,been |
R3223 |
T13792 |
T13790 |
prep |
of,One |
R3224 |
T13793 |
T13794 |
det |
the,questions |
R3225 |
T13794 |
T13792 |
pobj |
questions,of |
R3227 |
T13795 |
T13794 |
amod |
enduring,questions |
R3228 |
T13796 |
T13794 |
prep |
in,questions |
R3229 |
T13797 |
T13798 |
compound |
calpain,research |
R3231 |
T13798 |
T13796 |
pobj |
research,in |
R3232 |
T13799 |
T13791 |
aux |
has,been |
R3233 |
T13800 |
T13801 |
mark |
whether,possess |
R3235 |
T13801 |
T13791 |
ccomp |
possess,been |
R3236 |
T13802 |
T13803 |
det |
the,isoforms |
R3237 |
T13803 |
T13801 |
nsubj |
isoforms,possess |
R3239 |
T13804 |
T13803 |
nummod |
two,isoforms |
R3240 |
T13805 |
T13803 |
amod |
ubiquitous,isoforms |
R3241 |
T13806 |
T13803 |
punct |
", ",isoforms |
R3242 |
T13807 |
T13808 |
nmod |
μ,calpain |
R3243 |
T13808 |
T13803 |
appos |
calpain,isoforms |
R3245 |
T13809 |
T13807 |
punct |
-,μ |
R3246 |
T13810 |
T13807 |
cc |
and,μ |
R3247 |
T13811 |
T13807 |
conj |
m,μ |
R3248 |
T13812 |
T13808 |
punct |
-,calpain |
R3250 |
T13813 |
T13801 |
punct |
", ",possess |
R3251 |
T13814 |
T13815 |
amod |
distinct,roles |
R3253 |
T13815 |
T13801 |
dobj |
roles,possess |
R3254 |
T13816 |
T13817 |
advmod |
in,vivo |
R3255 |
T13817 |
T13815 |
amod |
vivo,roles |
R3257 |
T13818 |
T13791 |
punct |
.,been |
R3258 |
T13820 |
T13821 |
det |
The,enzymes |
R3260 |
T13821 |
T13823 |
nsubj |
enzymes,share |
R3261 |
T13822 |
T13821 |
nummod |
two,enzymes |
R3263 |
T13824 |
T13825 |
nummod |
62,% |
R3264 |
T13825 |
T13826 |
compound |
%,identity |
R3266 |
T13826 |
T13823 |
dobj |
identity,share |
R3267 |
T13827 |
T13826 |
compound |
sequence,identity |
R3268 |
T13828 |
T13823 |
cc |
and,share |
R3272 |
T13829 |
T13823 |
conj |
are,share |
R3273 |
T13830 |
T13831 |
advmod |
very,similar |
R3275 |
T13831 |
T13829 |
acomp |
similar,are |
R3276 |
T13832 |
T13829 |
prep |
in,are |
R3277 |
T13833 |
T13834 |
poss |
their,structure |
R3279 |
T13834 |
T13832 |
pobj |
structure,in |
R3280 |
T13835 |
T13834 |
cc |
and,structure |
R3282 |
T13836 |
T13834 |
conj |
biochemistry,structure |
R3283 |
T13837 |
T13823 |
punct |
.,share |
R3285 |
T13839 |
T13840 |
advmod |
Notably,cleave |
R3287 |
T13841 |
T13840 |
punct |
", ",cleave |
R3288 |
T13842 |
T13840 |
nsubj |
they,cleave |
R3289 |
T13843 |
T13840 |
advmod |
essentially,cleave |
R3292 |
T13844 |
T13845 |
det |
the,set |
R3293 |
T13845 |
T13840 |
dobj |
set,cleave |
R3295 |
T13846 |
T13845 |
amod |
same,set |
R3296 |
T13847 |
T13845 |
prep |
of,set |
R3297 |
T13848 |
T13847 |
pobj |
substrates,of |
R3299 |
T13849 |
T13850 |
advmod |
in,vitro |
R3300 |
T13850 |
T13840 |
advmod |
vitro,cleave |
R3302 |
T13851 |
T13840 |
punct |
", ",cleave |
R3303 |
T13852 |
T13840 |
advcl |
suggesting,cleave |
R3305 |
T13853 |
T13854 |
mark |
that,have |
R3306 |
T13854 |
T13852 |
ccomp |
have,suggesting |
R3307 |
T13855 |
T13854 |
nsubj |
they,have |
R3309 |
T13856 |
T13857 |
det |
the,potential |
R3310 |
T13857 |
T13854 |
dobj |
potential,have |
R3312 |
T13858 |
T13859 |
aux |
to,carry |
R3313 |
T13859 |
T13857 |
acl |
carry,potential |
R3314 |
T13860 |
T13859 |
prt |
out,carry |
R3316 |
T13861 |
T13862 |
det |
the,functions |
R3317 |
T13862 |
T13859 |
dobj |
functions,carry |
R3318 |
T13863 |
T13862 |
amod |
same,functions |
R3320 |
T13864 |
T13865 |
advmod |
in,vivo |
R3321 |
T13865 |
T13859 |
advmod |
vivo,carry |
R3323 |
T13866 |
T13840 |
punct |
.,cleave |
R3325 |
T13868 |
T13869 |
prep |
On,is |
R3327 |
T13870 |
T13871 |
det |
the,hand |
R3328 |
T13871 |
T13868 |
pobj |
hand,On |
R3329 |
T13872 |
T13871 |
amod |
other,hand |
R3331 |
T13873 |
T13869 |
punct |
", ",is |
R3332 |
T13874 |
T13875 |
mark |
since,require |
R3333 |
T13875 |
T13869 |
advcl |
require,is |
R3335 |
T13876 |
T13875 |
nsubj |
they,require |
R3336 |
T13877 |
T13878 |
amod |
different,amounts |
R3337 |
T13878 |
T13875 |
dobj |
amounts,require |
R3339 |
T13879 |
T13878 |
prep |
of,amounts |
R3340 |
T13880 |
T13879 |
pobj |
Ca2,of |
R3341 |
T13881 |
T13880 |
punct |
+,Ca2 |
R3343 |
T13882 |
T13875 |
prep |
for,require |
R3344 |
T13883 |
T13884 |
nmod |
in,vitro |
R3345 |
T13884 |
T13885 |
nmod |
vitro,activation |
R3346 |
T13885 |
T13882 |
pobj |
activation,for |
R3347 |
T13886 |
T13869 |
punct |
", ",is |
R3349 |
T13887 |
T13869 |
nsubj |
it,is |
R3350 |
T13888 |
T13869 |
acomp |
possible,is |
R3351 |
T13889 |
T13890 |
mark |
that,regulated |
R3353 |
T13890 |
T13869 |
ccomp |
regulated,is |
R3354 |
T13891 |
T13892 |
det |
the,isoforms |
R3356 |
T13892 |
T13890 |
nsubjpass |
isoforms,regulated |
R3357 |
T13893 |
T13892 |
nummod |
two,isoforms |
R3359 |
T13894 |
T13890 |
auxpass |
are,regulated |
R3360 |
T13895 |
T13890 |
advmod |
differentially,regulated |
R3361 |
T13896 |
T13890 |
prep |
inside,regulated |
R3363 |
T13897 |
T13896 |
pobj |
cells,inside |
R3364 |
T13898 |
T13869 |
punct |
.,is |
R3366 |
T13900 |
T13901 |
nsubj |
It,is |
R3368 |
T13902 |
T13901 |
advmod |
now,is |
R3369 |
T13903 |
T13901 |
acomp |
clear,is |
R3370 |
T13904 |
T13901 |
punct |
", ",is |
R3372 |
T13905 |
T13901 |
prep |
from,is |
R3373 |
T13906 |
T13907 |
det |
the,work |
R3374 |
T13907 |
T13905 |
pobj |
work,from |
R3376 |
T13908 |
T13909 |
compound |
gene,targeting |
R3377 |
T13909 |
T13907 |
compound |
targeting,work |
R3378 |
T13910 |
T13907 |
acl |
done,work |
R3380 |
T13911 |
T13910 |
prep |
in,done |
R3381 |
T13912 |
T13911 |
pobj |
mice,in |
R3383 |
T13913 |
T13901 |
punct |
", ",is |
R3384 |
T13914 |
T13915 |
mark |
that,have |
R3385 |
T13915 |
T13901 |
ccomp |
have,is |
R3387 |
T13916 |
T13917 |
nmod |
μ,calpain |
R3388 |
T13917 |
T13915 |
nsubj |
calpain,have |
R3389 |
T13918 |
T13916 |
punct |
-,μ |
R3391 |
T13919 |
T13916 |
cc |
and,μ |
R3392 |
T13920 |
T13916 |
conj |
m,μ |
R3393 |
T13921 |
T13917 |
punct |
-,calpain |
R3395 |
T13922 |
T13923 |
det |
some,roles |
R3396 |
T13923 |
T13915 |
dobj |
roles,have |
R3397 |
T13924 |
T13923 |
amod |
distinct,roles |
R3398 |
T13925 |
T13923 |
amod |
physiological,roles |
R3399 |
T13926 |
T13915 |
punct |
", ",have |
R3401 |
T13927 |
T13928 |
advmod |
at,least |
R3402 |
T13928 |
T13929 |
advmod |
least,during |
R3404 |
T13929 |
T13915 |
prep |
during,have |
R3406 |
T13930 |
T13929 |
pobj |
embryogenesis,during |
R3407 |
T13931 |
T13901 |
punct |
.,is |
R3409 |
T13933 |
T13934 |
mark |
As,noted |
R3411 |
T13934 |
T13935 |
advcl |
noted,affect |
R3414 |
T13936 |
T13935 |
punct |
", ",affect |
R3416 |
T13937 |
T13938 |
mark |
whereas,die |
R3417 |
T13938 |
T13935 |
advcl |
die,affect |
R3419 |
T13939 |
T13940 |
npadvmod |
Capn2,null |
R3420 |
T13940 |
T13941 |
amod |
null,embryos |
R3421 |
T13941 |
T13938 |
nsubj |
embryos,die |
R3423 |
T13942 |
T13941 |
amod |
murine,embryos |
R3424 |
T13943 |
T13944 |
amod |
prior,to |
R3426 |
T13944 |
T13938 |
prep |
to,die |
R3427 |
T13945 |
T13944 |
pobj |
implantation,to |
R3428 |
T13946 |
T13935 |
punct |
", ",affect |
R3430 |
T13947 |
T13948 |
amod |
homozygous,disruption |
R3431 |
T13948 |
T13935 |
nsubj |
disruption,affect |
R3432 |
T13949 |
T13948 |
prep |
of,disruption |
R3434 |
T13950 |
T13951 |
det |
the,gene |
R3435 |
T13951 |
T13949 |
pobj |
gene,of |
R3437 |
T13952 |
T13953 |
nmod |
μ,calpain |
R3438 |
T13953 |
T13951 |
nmod |
calpain,gene |
R3439 |
T13954 |
T13953 |
punct |
-,calpain |
R3441 |
T13955 |
T13951 |
amod |
large,gene |
R3442 |
T13956 |
T13951 |
compound |
subunit,gene |
R3444 |
T13957 |
T13951 |
punct |
", ",gene |
R3445 |
T13958 |
T13951 |
appos |
Capn1,gene |
R3446 |
T13959 |
T13935 |
punct |
", ",affect |
R3447 |
T13960 |
T13935 |
aux |
did,affect |
R3448 |
T13961 |
T13935 |
neg |
not,affect |
R3449 |
T13962 |
T13963 |
det |
the,viability |
R3450 |
T14041 |
T14040 |
amod |
relative,amounts |
R3451 |
T13963 |
T13935 |
dobj |
viability,affect |
R3452 |
T13964 |
T13963 |
prep |
of,viability |
R3453 |
T13965 |
T13964 |
pobj |
mice,of |
R3454 |
T13966 |
T13967 |
punct |
[,33 |
R3455 |
T13967 |
T13935 |
parataxis |
33,affect |
R3456 |
T13968 |
T13967 |
punct |
],33 |
R3457 |
T14042 |
T14013 |
punct |
.,are |
R3458 |
T13969 |
T13935 |
punct |
.,affect |
R3459 |
T13971 |
T13972 |
det |
The,phenotype |
R3460 |
T14044 |
T14045 |
nsubj |
Platelets,contain |
R3461 |
T13972 |
T13974 |
nsubj |
phenotype,involved |
R3462 |
T13973 |
T13972 |
amod |
principal,phenotype |
R3463 |
T14046 |
T14044 |
cc |
and,Platelets |
R3464 |
T13975 |
T13972 |
acl |
observed,phenotype |
R3465 |
T13976 |
T13975 |
prep |
as,observed |
R3466 |
T13977 |
T13978 |
det |
a,result |
R3467 |
T13978 |
T13976 |
pobj |
result,as |
R3468 |
T14047 |
T14044 |
conj |
erythrocytes,Platelets |
R3469 |
T13979 |
T13978 |
prep |
of,result |
R3470 |
T13980 |
T13981 |
compound |
Capn1,deficiency |
R3471 |
T13981 |
T13979 |
pobj |
deficiency,of |
R3472 |
T14048 |
T14049 |
amod |
abundant,activity |
R3473 |
T13982 |
T13983 |
det |
a,disturbance |
R3474 |
T13983 |
T13974 |
dobj |
disturbance,involved |
R3475 |
T13984 |
T13983 |
prep |
in,disturbance |
R3476 |
T14049 |
T14045 |
dobj |
activity,contain |
R3477 |
T13985 |
T13986 |
compound |
platelet,function |
R3478 |
T13986 |
T13984 |
pobj |
function,in |
R3479 |
T13987 |
T13983 |
punct |
", ",disturbance |
R3480 |
T14050 |
T14051 |
compound |
μ,calpain |
R3481 |
T13988 |
T13989 |
advmod |
possibly,at |
R3482 |
T13989 |
T13983 |
prep |
at,disturbance |
R3483 |
T13990 |
T13991 |
det |
the,level |
R3484 |
T14051 |
T14049 |
compound |
calpain,activity |
R3485 |
T13991 |
T13989 |
pobj |
level,at |
R3486 |
T13992 |
T13991 |
prep |
of,level |
R3487 |
T13993 |
T13994 |
det |
the,phosphorylation |
R3488 |
T14052 |
T14051 |
punct |
-,calpain |
R3489 |
T13994 |
T13992 |
pobj |
phosphorylation,of |
R3490 |
T13995 |
T13994 |
compound |
tyrosine,phosphorylation |
R3491 |
T13996 |
T13994 |
prep |
of,phosphorylation |
R3492 |
T14053 |
T14045 |
punct |
", ",contain |
R3493 |
T13997 |
T13998 |
amod |
certain,proteins |
R3494 |
T13998 |
T13996 |
pobj |
proteins,of |
R3495 |
T13999 |
T13998 |
acl |
involved,proteins |
R3496 |
T14054 |
T14055 |
mark |
while,is |
R3497 |
T14055 |
T14045 |
advcl |
is,contain |
R3498 |
T14000 |
T13999 |
prep |
in,involved |
R3499 |
T14001 |
T14002 |
compound |
platelet,activation |
R3500 |
T14002 |
T14000 |
pobj |
activation,in |
R3501 |
T14003 |
T13974 |
punct |
.,involved |
R3502 |
T14056 |
T14057 |
compound |
m,calpain |
R3503 |
T14005 |
T14006 |
preconj |
Both,activities |
R3504 |
T14006 |
T14013 |
nsubj |
activities,are |
R3505 |
T14057 |
T14059 |
compound |
calpain,activity |
R3506 |
T14007 |
T14008 |
nmod |
μ,calpain |
R3507 |
T14008 |
T14006 |
compound |
calpain,activities |
R3508 |
T14009 |
T14007 |
punct |
-,μ |
R3509 |
T14058 |
T14057 |
punct |
-,calpain |
R3510 |
T14010 |
T14007 |
cc |
and,μ |
R3511 |
T14011 |
T14007 |
conj |
m,μ |
R3512 |
T14012 |
T14008 |
punct |
-,calpain |
R3513 |
T14059 |
T14055 |
nsubj |
activity,is |
R3514 |
T14014 |
T14013 |
acomp |
present,are |
R3515 |
T14060 |
T14061 |
advmod |
barely,detectable |
R3516 |
T14015 |
T14013 |
prep |
in,are |
R3517 |
T14061 |
T14055 |
acomp |
detectable,is |
R3518 |
T14062 |
T14045 |
punct |
.,contain |
R3519 |
T14016 |
T14017 |
amod |
most,cells |
R3520 |
T14017 |
T14015 |
pobj |
cells,in |
R3521 |
T14018 |
T14017 |
amod |
mammalian,cells |
R3522 |
T14064 |
T14065 |
nsubj |
Compensation,is |
R3523 |
T14019 |
T14013 |
punct |
", ",are |
R3524 |
T14020 |
T14021 |
mark |
although,provide |
R3525 |
T14066 |
T14064 |
prep |
for,Compensation |
R3526 |
T14021 |
T14013 |
advcl |
provide,are |
R3527 |
T14022 |
T14023 |
det |
the,data |
R3528 |
T14023 |
T14021 |
nsubj |
data,provide |
R3529 |
T14024 |
T14023 |
amod |
published,data |
R3530 |
T14067 |
T14068 |
compound |
μ,calpain |
R3531 |
T14025 |
T14023 |
punct |
", ",data |
R3532 |
T14026 |
T14023 |
prep |
owing,data |
R3533 |
T14027 |
T14026 |
prep |
to,owing |
R3534 |
T14068 |
T14070 |
compound |
calpain,deficiency |
R3535 |
T14028 |
T14027 |
pobj |
weaknesses,to |
R3536 |
T14029 |
T14028 |
prep |
in,weaknesses |
R3537 |
T14030 |
T14031 |
det |
the,methodology |
R3538 |
T14069 |
T14068 |
punct |
-,calpain |
R3539 |
T14031 |
T14029 |
pobj |
methodology,in |
R3540 |
T14032 |
T14031 |
amod |
available,methodology |
R3541 |
T14033 |
T14021 |
punct |
", ",provide |
R3542 |
T14070 |
T14066 |
pobj |
deficiency,for |
R3543 |
T14034 |
T14021 |
aux |
do,provide |
R3544 |
T14035 |
T14021 |
neg |
not,provide |
R3545 |
T14036 |
T14037 |
amod |
reliable,estimates |
R3546 |
T14071 |
T14064 |
prep |
by,Compensation |
R3547 |
T14037 |
T14021 |
dobj |
estimates,provide |
R3548 |
T14038 |
T14037 |
prep |
of,estimates |
R3549 |
T14039 |
T14040 |
poss |
their,amounts |
R3550 |
T14072 |
T14073 |
compound |
m,calpain |
R3551 |
T14040 |
T14038 |
pobj |
amounts,of |
R3552 |
T14073 |
T14071 |
pobj |
calpain,by |
R3553 |
T14074 |
T14073 |
punct |
-,calpain |
R3554 |
T14075 |
T14065 |
advmod |
therefore,is |
R3555 |
T14147 |
T14145 |
punct |
-,Capn2 |
R3556 |
T14076 |
T14077 |
advmod |
less,likely |
R3557 |
T14148 |
T14145 |
punct |
/,Capn2 |
R3558 |
T14149 |
T14145 |
punct |
-,Capn2 |
R3559 |
T14077 |
T14065 |
acomp |
likely,is |
R3560 |
T14150 |
T14151 |
mark |
that,is |
R3561 |
T14151 |
T14140 |
ccomp |
is,demonstrates |
R3562 |
T14078 |
T14077 |
prep |
in,likely |
R3563 |
T14152 |
T14153 |
compound |
m,calpain |
R3564 |
T14153 |
T14155 |
compound |
calpain,activity |
R3565 |
T14154 |
T14153 |
punct |
-,calpain |
R3566 |
T14079 |
T14078 |
pobj |
platelets,in |
R3567 |
T14155 |
T14151 |
nsubj |
activity,is |
R3568 |
T14156 |
T14151 |
acomp |
essential,is |
R3569 |
T14157 |
T14156 |
prep |
for,essential |
R3570 |
T14080 |
T14079 |
cc |
and,platelets |
R3571 |
T14158 |
T14159 |
amod |
embryonic,development |
R3572 |
T14159 |
T14157 |
pobj |
development,for |
R3573 |
T14160 |
T14159 |
prep |
beyond,development |
R3574 |
T14081 |
T14079 |
conj |
erythrocytes,platelets |
R3575 |
T14161 |
T14162 |
det |
the,stage |
R3576 |
T14162 |
T14160 |
pobj |
stage,beyond |
R3577 |
T14082 |
T14077 |
prep |
than,likely |
R3578 |
T14163 |
T14164 |
nummod |
8,cell |
R3579 |
T14164 |
T14162 |
compound |
cell,stage |
R3580 |
T14165 |
T14164 |
punct |
-,cell |
R3581 |
T14083 |
T14082 |
prep |
in,than |
R3582 |
T14166 |
T14140 |
punct |
.,demonstrates |
R3583 |
T14168 |
T14169 |
nsubj |
It,follows |
R3584 |
T14084 |
T14085 |
amod |
other,types |
R3585 |
T14170 |
T14171 |
mark |
that,are |
R3586 |
T14171 |
T14169 |
ccomp |
are,follows |
R3587 |
T14085 |
T14083 |
pobj |
types,in |
R3588 |
T14172 |
T14173 |
advmod |
at,least |
R3589 |
T14173 |
T14174 |
advmod |
least,functions |
R3590 |
T14086 |
T14085 |
compound |
cell,types |
R3591 |
T14174 |
T14171 |
nsubj |
functions,are |
R3592 |
T14175 |
T14174 |
det |
some,functions |
R3593 |
T14176 |
T14174 |
prep |
of,functions |
R3594 |
T14087 |
T14065 |
punct |
.,is |
R3595 |
T14177 |
T14178 |
compound |
μ,calpain |
R3596 |
T14178 |
T14176 |
pobj |
calpain,of |
R3597 |
T14179 |
T14178 |
punct |
-,calpain |
R3598 |
T14089 |
T14090 |
prep |
As,is |
R3599 |
T14180 |
T14178 |
cc |
and,calpain |
R3600 |
T14181 |
T14182 |
compound |
m,calpain |
R3601 |
T14182 |
T14178 |
conj |
calpain,calpain |
R3602 |
T14183 |
T14182 |
punct |
-,calpain |
R3603 |
T14184 |
T14171 |
acomp |
distinct,are |
R3604 |
T14185 |
T14169 |
punct |
.,follows |
R3605 |
T14091 |
T14092 |
det |
a,result |
R3607 |
T14092 |
T14089 |
pobj |
result,As |
R3610 |
T14093 |
T14090 |
punct |
", ",is |
R3614 |
T14094 |
T14090 |
nsubj |
it,is |
R3618 |
T14095 |
T14090 |
neg |
not,is |
R3621 |
T14096 |
T14090 |
acomp |
possible,is |
R3625 |
T14097 |
T14098 |
aux |
to,determine |
R3629 |
T14098 |
T14090 |
xcomp |
determine,is |
R3631 |
T14099 |
T14100 |
mark |
whether,is |
R3635 |
T14100 |
T14098 |
advcl |
is,determine |
R3638 |
T14101 |
T14102 |
det |
the,absence |
R3642 |
T14102 |
T14100 |
nsubj |
absence,is |
R3646 |
T14103 |
T14102 |
prep |
of,absence |
R3650 |
T14104 |
T14105 |
amod |
marked,phenotype |
R3653 |
T14105 |
T14103 |
pobj |
phenotype,of |
R3658 |
T14106 |
T14102 |
prep |
in,absence |
R3662 |
T14107 |
T14108 |
nmod |
Capn1,animals |
R3666 |
T14108 |
T14106 |
pobj |
animals,in |
R3670 |
T14109 |
T14107 |
punct |
-,Capn1 |
R3674 |
T14110 |
T14107 |
punct |
/,Capn1 |
R3678 |
T14111 |
T14107 |
punct |
-,Capn1 |
R3682 |
T14112 |
T14100 |
prep |
due,is |
R3685 |
T14113 |
T14112 |
pcomp |
to,due |
R3689 |
T14114 |
T14115 |
det |
a,affect |
R3690 |
T14115 |
T14112 |
pobj |
affect,due |
R3691 |
T14116 |
T14115 |
amod |
compensatory,affect |
R3693 |
T14117 |
T14115 |
prep |
by,affect |
R3696 |
T14118 |
T14119 |
det |
the,activity |
R3699 |
T14119 |
T14117 |
pobj |
activity,by |
R3702 |
T14120 |
T14119 |
amod |
remaining,activity |
R3709 |
T14121 |
T14122 |
compound |
m,calpain |
R3712 |
T14122 |
T14119 |
compound |
calpain,activity |
R3715 |
T14123 |
T14122 |
punct |
-,calpain |
R3718 |
T14124 |
T14100 |
punct |
", ",is |
R3722 |
T14125 |
T14100 |
cc |
or,is |
R3723 |
T14126 |
T14127 |
mark |
whether,are |
R3725 |
T14127 |
T14100 |
conj |
are,is |
R3729 |
T14128 |
T14129 |
det |
the,functions |
R3733 |
T14129 |
T14127 |
nsubj |
functions,are |
R3736 |
T14130 |
T14129 |
prep |
of,functions |
R3739 |
T14131 |
T14132 |
compound |
μ,calpain |
R3743 |
T14132 |
T14130 |
pobj |
calpain,of |
R3746 |
T14133 |
T14132 |
punct |
-,calpain |
R3749 |
T14134 |
T14127 |
advmod |
simply,are |
R3752 |
T14135 |
T14127 |
neg |
not,are |
R3756 |
T14136 |
T14127 |
acomp |
essential,are |
R3762 |
T14137 |
T14090 |
punct |
.,is |
R3766 |
T14139 |
T14140 |
prep |
In,demonstrates |
R3771 |
T14141 |
T14139 |
pobj |
contrast,In |
R3774 |
T14142 |
T14140 |
punct |
", ",demonstrates |
R3778 |
T14143 |
T14140 |
nsubj |
lethality,demonstrates |
R3781 |
T14144 |
T14143 |
prep |
in,lethality |
R3785 |
T14145 |
T14146 |
nmod |
Capn2,embryos |
R3788 |
T14146 |
T14144 |
pobj |
embryos,in |