PMC:1382200 / 18374-18640 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T13222","span":{"begin":265,"end":266},"obj":"."},{"id":"T13221","span":{"begin":264,"end":265},"obj":"-RRB-"},{"id":"T13220","span":{"begin":262,"end":264},"obj":"CD"},{"id":"T13219","span":{"begin":261,"end":262},"obj":"-LRB-"},{"id":"T13218","span":{"begin":247,"end":251},"obj":"RB"},{"id":"T13217","span":{"begin":243,"end":246},"obj":"VBD"},{"id":"T13216","span":{"begin":235,"end":242},"obj":"NNS"},{"id":"T13215","span":{"begin":230,"end":234},"obj":"JJ"},{"id":"T13214","span":{"begin":227,"end":229},"obj":"IN"},{"id":"T13213","span":{"begin":217,"end":226},"obj":"NN"},{"id":"T13212","span":{"begin":201,"end":216},"obj":"NN"},{"id":"T13211","span":{"begin":195,"end":200},"obj":"WDT"},{"id":"T13210","span":{"begin":252,"end":260},"obj":"VBN"},{"id":"T13209","span":{"begin":192,"end":194},"obj":"IN"},{"id":"T13208","span":{"begin":177,"end":185},"obj":"VBN"},{"id":"T13207","span":{"begin":171,"end":176},"obj":"NN"},{"id":"T13206","span":{"begin":167,"end":170},"obj":"CD"},{"id":"T13205","span":{"begin":186,"end":191},"obj":"NNS"},{"id":"T13204","span":{"begin":163,"end":166},"obj":"DT"},{"id":"T13203","span":{"begin":160,"end":162},"obj":"IN"},{"id":"T13202","span":{"begin":156,"end":159},"obj":"CD"},{"id":"T13201","span":{"begin":153,"end":155},"obj":"IN"},{"id":"T13200","span":{"begin":143,"end":152},"obj":"VBN"},{"id":"T13199","span":{"begin":133,"end":142},"obj":"NN"},{"id":"T13198","span":{"begin":129,"end":132},"obj":"DT"},{"id":"T13197","span":{"begin":124,"end":128},"obj":"IN"},{"id":"T13196","span":{"begin":114,"end":123},"obj":"NN"},{"id":"T13195","span":{"begin":111,"end":113},"obj":"IN"},{"id":"T13194","span":{"begin":101,"end":107},"obj":"NN"},{"id":"T13193","span":{"begin":96,"end":100},"obj":"DT"},{"id":"T13192","span":{"begin":94,"end":96},"obj":","},{"id":"T13191","span":{"begin":86,"end":94},"obj":"NN"},{"id":"T13190","span":{"begin":77,"end":78},"obj":"HYPH"},{"id":"T13189","span":{"begin":78,"end":85},"obj":"NN"},{"id":"T13188","span":{"begin":76,"end":77},"obj":"NN"},{"id":"T13187","span":{"begin":68,"end":75},"obj":"VB"},{"id":"T13186","span":{"begin":65,"end":67},"obj":"TO"},{"id":"T13185","span":{"begin":108,"end":110},"obj":"VBZ"},{"id":"T13184","span":{"begin":51,"end":55},"obj":"RB"},{"id":"T13183","span":{"begin":47,"end":50},"obj":"VBD"},{"id":"T13182","span":{"begin":36,"end":41},"obj":"NN"},{"id":"T13181","span":{"begin":42,"end":46},"obj":"NN"},{"id":"T13180","span":{"begin":32,"end":35},"obj":"DT"},{"id":"T13179","span":{"begin":29,"end":31},"obj":"IN"},{"id":"T13178","span":{"begin":18,"end":28},"obj":"NN"},{"id":"T13177","span":{"begin":7,"end":17},"obj":"JJ"},{"id":"T13176","span":{"begin":56,"end":64},"obj":"VBN"},{"id":"T13175","span":{"begin":1,"end":6},"obj":"IN"},{"id":"T13174","span":{"begin":0,"end":266},"obj":"sentence"}],"relations":[{"id":"R2698","pred":"mark","subj":"T13175","obj":"T13176"},{"id":"R2699","pred":"advcl","subj":"T13176","obj":"T13185"},{"id":"R2700","pred":"amod","subj":"T13177","obj":"T13178"},{"id":"R2702","pred":"nsubjpass","subj":"T13178","obj":"T13176"},{"id":"R2704","pred":"prep","subj":"T13179","obj":"T13178"},{"id":"R2705","pred":"det","subj":"T13180","obj":"T13181"},{"id":"R2706","pred":"pobj","subj":"T13181","obj":"T13179"},{"id":"R2708","pred":"compound","subj":"T13182","obj":"T13181"},{"id":"R2709","pred":"auxpass","subj":"T13183","obj":"T13176"},{"id":"R2711","pred":"advmod","subj":"T13184","obj":"T13176"},{"id":"R2712","pred":"aux","subj":"T13186","obj":"T13187"},{"id":"R2713","pred":"xcomp","subj":"T13187","obj":"T13176"},{"id":"R2715","pred":"compound","subj":"T13188","obj":"T13189"},{"id":"R2716","pred":"compound","subj":"T13189","obj":"T13191"},{"id":"R2717","pred":"punct","subj":"T13190","obj":"T13189"},{"id":"R2719","pred":"dobj","subj":"T13191","obj":"T13187"},{"id":"R2720","pred":"punct","subj":"T13192","obj":"T13185"},{"id":"R2722","pred":"det","subj":"T13193","obj":"T13194"},{"id":"R2723","pred":"nsubj","subj":"T13194","obj":"T13185"},{"id":"R2725","pred":"prep","subj":"T13195","obj":"T13185"},{"id":"R2727","pred":"pobj","subj":"T13196","obj":"T13195"},{"id":"R2728","pred":"prep","subj":"T13197","obj":"T13196"},{"id":"R2729","pred":"det","subj":"T13198","obj":"T13199"},{"id":"R2730","pred":"pobj","subj":"T13199","obj":"T13197"},{"id":"R2731","pred":"acl","subj":"T13200","obj":"T13199"},{"id":"R2733","pred":"agent","subj":"T13201","obj":"T13200"},{"id":"R2734","pred":"pobj","subj":"T13202","obj":"T13201"},{"id":"R2735","pred":"prep","subj":"T13203","obj":"T13202"},{"id":"R2737","pred":"det","subj":"T13204","obj":"T13205"},{"id":"R2738","pred":"pobj","subj":"T13205","obj":"T13203"},{"id":"R2740","pred":"nummod","subj":"T13206","obj":"T13205"},{"id":"R2741","pred":"npadvmod","subj":"T13207","obj":"T13208"},{"id":"R2742","pred":"amod","subj":"T13208","obj":"T13205"},{"id":"R2743","pred":"prep","subj":"T13209","obj":"T13210"},{"id":"R2745","pred":"relcl","subj":"T13210","obj":"T13205"},{"id":"R2746","pred":"pobj","subj":"T13211","obj":"T13209"},{"id":"R2747","pred":"compound","subj":"T13212","obj":"T13213"},{"id":"R2749","pred":"nsubjpass","subj":"T13213","obj":"T13210"},{"id":"R2750","pred":"prep","subj":"T13214","obj":"T13213"},{"id":"R2751","pred":"amod","subj":"T13215","obj":"T13216"},{"id":"R2752","pred":"pobj","subj":"T13216","obj":"T13214"},{"id":"R2754","pred":"auxpass","subj":"T13217","obj":"T13210"},{"id":"R2755","pred":"advmod","subj":"T13218","obj":"T13210"},{"id":"R2756","pred":"punct","subj":"T13219","obj":"T13220"},{"id":"R2759","pred":"parataxis","subj":"T13220","obj":"T13210"},{"id":"R2761","pred":"punct","subj":"T13221","obj":"T13220"},{"id":"R2762","pred":"punct","subj":"T13222","obj":"T13185"}],"text":" Since homozygous disruption of the Capn4 gene was also expected to abolish m-calpain activity, this result is in agreement with the phenotype presented by one of the two Capn4 targeted lines in which preimplantation lethality of null embryos was also observed [32]."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T12234","span":{"begin":235,"end":242},"obj":"UBERON:0000922"},{"id":"T12233","span":{"begin":204,"end":216},"obj":"GO:0007566"},{"id":"T12232","span":{"begin":171,"end":176},"obj":"PR:000005022"},{"id":"T12231","span":{"begin":42,"end":46},"obj":"SO:0000704"},{"id":"T12230","span":{"begin":36,"end":41},"obj":"PR:000005022"}],"text":" Since homozygous disruption of the Capn4 gene was also expected to abolish m-calpain activity, this result is in agreement with the phenotype presented by one of the two Capn4 targeted lines in which preimplantation lethality of null embryos was also observed [32]."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T12472","span":{"begin":235,"end":242},"obj":"UBERON:0000922"},{"id":"T12471","span":{"begin":230,"end":234},"obj":"SO_EXT:sequence_nullness"},{"id":"T12470","span":{"begin":217,"end":226},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T12469","span":{"begin":204,"end":216},"obj":"GO:0007566"},{"id":"T12468","span":{"begin":171,"end":176},"obj":"PR_EXT:000005022"},{"id":"T12467","span":{"begin":76,"end":85},"obj":"GO_PR_EXT:calpain_2_complex"},{"id":"T12466","span":{"begin":42,"end":46},"obj":"SO_EXT:0000704"},{"id":"T12465","span":{"begin":36,"end":41},"obj":"PR_EXT:000005022"}],"text":" Since homozygous disruption of the Capn4 gene was also expected to abolish m-calpain activity, this result is in agreement with the phenotype presented by one of the two Capn4 targeted lines in which preimplantation lethality of null embryos was also observed [32]."}