Id |
Subject |
Object |
Predicate |
Lexical cue |
T13127 |
1683-1684 |
. |
denotes |
. |
T13126 |
1674-1683 |
NN |
denotes |
viability |
T13125 |
1664-1673 |
JJ |
denotes |
embryonic |
T13124 |
1653-1663 |
VBG |
denotes |
sustaining |
T13123 |
1649-1652 |
IN |
denotes |
for |
T13122 |
1638-1648 |
JJ |
denotes |
sufficient |
T13121 |
1628-1633 |
RB |
denotes |
alone |
T13120 |
1620-1627 |
NN |
denotes |
isoform |
T13119 |
1613-1619 |
DT |
denotes |
either |
T13118 |
1634-1637 |
VBD |
denotes |
was |
T13117 |
1608-1612 |
IN |
denotes |
that |
T13116 |
1605-1607 |
CC |
denotes |
or |
T13115 |
1603-1605 |
, |
denotes |
, |
T13114 |
1590-1603 |
NN |
denotes |
embryogenesis |
T13113 |
1583-1589 |
IN |
denotes |
during |
T13112 |
1561-1573 |
RB |
denotes |
specifically |
T13111 |
1557-1560 |
VBD |
denotes |
was |
T13110 |
1548-1549 |
HYPH |
denotes |
- |
T13109 |
1547-1548 |
NN |
denotes |
m |
T13108 |
1549-1556 |
NN |
denotes |
calpain |
T13107 |
1540-1546 |
DT |
denotes |
either |
T13106 |
1574-1582 |
VBN |
denotes |
required |
T13105 |
1535-1539 |
IN |
denotes |
that |
T13104 |
1517-1520 |
CD |
denotes |
two |
T13103 |
1512-1516 |
JJ |
denotes |
last |
T13102 |
1521-1534 |
NNS |
denotes |
possibilities |
T13101 |
1508-1511 |
DT |
denotes |
the |
T13100 |
1503-1507 |
IN |
denotes |
with |
T13099 |
1493-1497 |
VBD |
denotes |
were |
T13098 |
1490-1492 |
PRP |
denotes |
we |
T13097 |
1488-1490 |
, |
denotes |
, |
T13096 |
1483-1488 |
NN |
denotes |
point |
T13095 |
1478-1482 |
DT |
denotes |
that |
T13094 |
1498-1502 |
VBN |
denotes |
left |
T13093 |
1475-1477 |
IN |
denotes |
At |
T13092 |
1474-1684 |
sentence |
denotes |
At that point, we were left with the last two possibilities that either m-calpain was specifically required during embryogenesis, or that either isoform alone was sufficient for sustaining embryonic viability. |
T13091 |
1473-1474 |
. |
denotes |
. |
T13090 |
1472-1473 |
-RRB- |
denotes |
] |
T13089 |
1470-1472 |
CD |
denotes |
33 |
T13088 |
1469-1470 |
-LRB- |
denotes |
[ |
T13087 |
1455-1459 |
VBD |
denotes |
were |
T13086 |
1436-1446 |
NN |
denotes |
retraction |
T13085 |
1431-1435 |
NN |
denotes |
clot |
T13084 |
1427-1430 |
CC |
denotes |
and |
T13083 |
1447-1454 |
NNS |
denotes |
defects |
T13082 |
1415-1426 |
NN |
denotes |
aggregation |
T13081 |
1406-1414 |
NN |
denotes |
platelet |
T13080 |
1460-1468 |
VBN |
denotes |
observed |
T13079 |
1397-1405 |
IN |
denotes |
although |
T13078 |
1395-1397 |
, |
denotes |
, |
T13077 |
1388-1395 |
JJ |
denotes |
fertile |
T13076 |
1384-1387 |
CC |
denotes |
and |
T13075 |
1376-1383 |
JJ |
denotes |
healthy |
T13074 |
1369-1371 |
, |
denotes |
, |
T13073 |
1352-1361 |
JJ |
denotes |
catalytic |
T13072 |
1343-1344 |
HYPH |
denotes |
- |
T13071 |
1344-1351 |
NN |
denotes |
calpain |
T13070 |
1342-1343 |
NN |
denotes |
μ |
T13069 |
1362-1369 |
NN |
denotes |
subunit |
T13068 |
1338-1341 |
DT |
denotes |
the |
T13067 |
1333-1337 |
VBP |
denotes |
lack |
T12957 |
805-813 |
NN |
denotes |
knockout |
T12956 |
814-818 |
NNS |
denotes |
mice |
T12955 |
799-804 |
NN |
denotes |
Capn4 |
T12954 |
796-798 |
IN |
denotes |
in |
T12953 |
786-795 |
NN |
denotes |
lethality |
T12952 |
776-785 |
JJ |
denotes |
embryonic |
T12951 |
767-775 |
VBD |
denotes |
observed |
T12950 |
742-753 |
JJ |
denotes |
independent |
T12949 |
754-766 |
NNS |
denotes |
laboratories |
T12948 |
738-741 |
CD |
denotes |
Two |
T12947 |
737-870 |
sentence |
denotes |
Two independent laboratories observed embryonic lethality in Capn4 knockout mice, albeit at different stages of development [31,32]. |
T12946 |
736-737 |
. |
denotes |
. |
T12945 |
728-729 |
HYPH |
denotes |
- |
T12944 |
727-728 |
NN |
denotes |
m |
T12943 |
723-726 |
CC |
denotes |
and |
T12942 |
721-722 |
HYPH |
denotes |
- |
T12941 |
720-721 |
NN |
denotes |
μ |
T12940 |
729-736 |
NN |
denotes |
calpain |
T12939 |
715-719 |
CC |
denotes |
both |
T12938 |
712-714 |
IN |
denotes |
to |
T12937 |
705-711 |
JJ |
denotes |
common |
T12936 |
686-696 |
JJ |
denotes |
regulatory |
T12935 |
680-685 |
JJ |
denotes |
small |
T12934 |
697-704 |
NN |
denotes |
subunit |
T12933 |
676-679 |
DT |
denotes |
the |
T12932 |
667-675 |
VBG |
denotes |
encoding |
T12931 |
665-667 |
, |
denotes |
, |
T12930 |
655-660 |
NN |
denotes |
Capn4 |
T12929 |
661-665 |
NN |
denotes |
gene |
T12928 |
651-654 |
DT |
denotes |
the |
T12927 |
643-650 |
VB |
denotes |
disrupt |
T12926 |
640-642 |
TO |
denotes |
to |
T12925 |
629-634 |
RB |
denotes |
first |
T12924 |
625-628 |
VBD |
denotes |
was |
T12923 |
635-639 |
VBN |
denotes |
used |
T12922 |
620-624 |
DT |
denotes |
This |
T12921 |
619-737 |
sentence |
denotes |
This was first used to disrupt the Capn4 gene, encoding the small regulatory subunit common to both μ- and m-calpain. |
T12920 |
618-619 |
. |
denotes |
. |
T12919 |
602-609 |
NN |
denotes |
calpain |
T12918 |
610-618 |
NNS |
denotes |
isoforms |
T12917 |
591-601 |
JJ |
denotes |
individual |
T12916 |
588-590 |
IN |
denotes |
of |
T12915 |
570-581 |
JJ |
denotes |
physiologic |
T12914 |
582-587 |
NNS |
denotes |
roles |
T12913 |
566-569 |
DT |
denotes |
the |
T12912 |
558-565 |
VB |
denotes |
examine |
T12911 |
555-557 |
TO |
denotes |
to |
T12910 |
537-545 |
JJ |
denotes |
powerful |
T12909 |
546-554 |
NN |
denotes |
approach |
T12908 |
535-536 |
DT |
denotes |
a |
T12907 |
522-525 |
VBZ |
denotes |
has |
T12906 |
517-521 |
NNS |
denotes |
mice |
T12905 |
514-516 |
IN |
denotes |
in |
T12904 |
526-534 |
VBN |
denotes |
provided |
T12903 |
504-513 |
NN |
denotes |
targeting |
T12902 |
499-503 |
NN |
denotes |
Gene |
T12901 |
498-619 |
sentence |
denotes |
Gene targeting in mice has provided a powerful approach to examine the physiologic roles of individual calpain isoforms. |
T12900 |
497-498 |
. |
denotes |
. |
T12899 |
476-485 |
NN |
denotes |
substrate |
T12898 |
486-497 |
NN |
denotes |
specificity |
T12897 |
466-475 |
JJ |
denotes |
different |
T12896 |
461-465 |
VBP |
denotes |
have |
T12895 |
457-460 |
CC |
denotes |
and |
T12894 |
435-446 |
RB |
denotes |
differently |
T12893 |
432-434 |
VB |
denotes |
be |
T12892 |
428-431 |
MD |
denotes |
may |
T12891 |
447-456 |
VBN |
denotes |
regulated |
T12890 |
422-427 |
WDT |
denotes |
which |
T12889 |
413-421 |
NNS |
denotes |
isoforms |
T12888 |
405-412 |
JJ |
denotes |
unknown |
T12887 |
394-404 |
RB |
denotes |
previously |
T12886 |
391-393 |
IN |
denotes |
of |
T12885 |
384-390 |
NN |
denotes |
number |
T12884 |
382-383 |
DT |
denotes |
a |
T12883 |
379-381 |
IN |
denotes |
of |
T12882 |
369-378 |
NN |
denotes |
discovery |
T12881 |
365-368 |
DT |
denotes |
the |
T12880 |
362-364 |
IN |
denotes |
by |
T12879 |
342-349 |
RB |
denotes |
further |
T12878 |
337-341 |
VBN |
denotes |
been |
T12877 |
333-336 |
VBZ |
denotes |
has |
T12876 |
327-332 |
NN |
denotes |
story |
T12875 |
323-326 |
DT |
denotes |
the |
T12874 |
321-323 |
, |
denotes |
, |
T12873 |
310-314 |
JJ |
denotes |
past |
T12872 |
315-321 |
NN |
denotes |
decade |
T12871 |
306-309 |
DT |
denotes |
the |
T12870 |
350-361 |
VBN |
denotes |
complicated |
T12869 |
303-305 |
IN |
denotes |
In |
T12868 |
302-498 |
sentence |
denotes |
In the past decade, the story has been further complicated by the discovery of a number of previously unknown isoforms which may be differently regulated and have different substrate specificity. |
T12867 |
301-302 |
. |
denotes |
. |
T12866 |
292-301 |
NNS |
denotes |
proteases |
T12865 |
286-291 |
JJ |
denotes |
other |
T12864 |
276-285 |
VBG |
denotes |
affecting |
T12863 |
268-275 |
IN |
denotes |
without |
T12862 |
259-267 |
NNS |
denotes |
calpains |
T12861 |
255-258 |
DT |
denotes |
the |
T12860 |
243-244 |
HYPH |
denotes |
- |
T12859 |
239-243 |
RB |
denotes |
down |
T12858 |
244-254 |
VBG |
denotes |
regulating |
T12857 |
226-238 |
RB |
denotes |
specifically |
T12856 |
223-225 |
IN |
denotes |
of |
T12855 |
215-222 |
JJ |
denotes |
capable |
T12854 |
204-214 |
NNS |
denotes |
inhibitors |
T12853 |
201-203 |
IN |
denotes |
of |
T12852 |
196-200 |
NN |
denotes |
lack |
T12851 |
192-195 |
DT |
denotes |
the |
T12850 |
189-191 |
IN |
denotes |
to |
T12849 |
185-188 |
IN |
denotes |
due |
T12848 |
176-179 |
VBZ |
denotes |
has |
T12847 |
171-175 |
DT |
denotes |
this |
T12846 |
169-171 |
, |
denotes |
, |
T12845 |
165-169 |
NN |
denotes |
part |
T12844 |
159-164 |
JJ |
denotes |
large |
T12843 |
180-184 |
VBN |
denotes |
been |
T12842 |
156-158 |
IN |
denotes |
In |
T12841 |
155-302 |
sentence |
denotes |
In large part, this has been due to the lack of inhibitors capable of specifically down-regulating the calpains without affecting other proteases. |
T12840 |
154-155 |
. |
denotes |
. |
T12839 |
147-154 |
JJ |
denotes |
elusive |
T12838 |
134-137 |
VBZ |
denotes |
has |
T12837 |
126-133 |
NNS |
denotes |
enzymes |
T12836 |
122-125 |
DT |
denotes |
the |
T12835 |
119-121 |
IN |
denotes |
of |
T12834 |
109-118 |
NNS |
denotes |
functions |
T12833 |
105-108 |
CC |
denotes |
and |
T12832 |
94-104 |
NNS |
denotes |
substrates |
T12831 |
90-93 |
DT |
denotes |
the |
T12830 |
87-89 |
IN |
denotes |
of |
T12829 |
67-72 |
JJ |
denotes |
clear |
T12828 |
73-86 |
NN |
denotes |
understanding |
T12827 |
65-66 |
DT |
denotes |
a |
T12826 |
63-65 |
, |
denotes |
, |
T12825 |
60-63 |
RB |
denotes |
ago |
T12824 |
52-59 |
NNS |
denotes |
decades |
T12823 |
47-51 |
CD |
denotes |
four |
T12822 |
138-146 |
VBN |
denotes |
remained |
T12821 |
30-35 |
RB |
denotes |
first |
T12820 |
26-29 |
VBD |
denotes |
was |
T12819 |
17-25 |
NN |
denotes |
activity |
T12818 |
9-16 |
NN |
denotes |
calpain |
T12817 |
36-46 |
VBN |
denotes |
identified |
T12816 |
0-8 |
IN |
denotes |
Although |
T13066 |
1327-1332 |
WDT |
denotes |
which |
T13065 |
1325-1327 |
, |
denotes |
, |
T13064 |
1319-1320 |
SYM |
denotes |
- |
T13063 |
1318-1319 |
HYPH |
denotes |
/ |
T13062 |
1317-1318 |
SYM |
denotes |
- |
T13061 |
1321-1325 |
NNS |
denotes |
mice |
T13060 |
1312-1317 |
NN |
denotes |
Capn1 |
T13059 |
1371-1375 |
VBD |
denotes |
were |
T13058 |
1307-1311 |
IN |
denotes |
that |
T13057 |
1284-1294 |
JJ |
denotes |
subsequent |
T13056 |
1295-1306 |
NN |
denotes |
observation |
T13055 |
1280-1283 |
DT |
denotes |
the |
T13054 |
1277-1279 |
IN |
denotes |
by |
T13053 |
1272-1276 |
RP |
denotes |
down |
T13052 |
1258-1262 |
VBD |
denotes |
were |
T13051 |
1263-1271 |
VBN |
denotes |
narrowed |
T13050 |
1250-1257 |
NNS |
denotes |
options |
T13049 |
1244-1249 |
DT |
denotes |
These |
T13048 |
1243-1474 |
sentence |
denotes |
These options were narrowed down by the subsequent observation that Capn1-/- mice, which lack the μ-calpain catalytic subunit, were healthy and fertile, although platelet aggregation and clot retraction defects were observed [33]. |
T13047 |
1242-1243 |
. |
denotes |
. |
T13046 |
1230-1233 |
VBD |
denotes |
was |
T13045 |
1222-1229 |
NN |
denotes |
isoform |
T13044 |
1216-1221 |
JJ |
denotes |
other |
T13043 |
1212-1215 |
DT |
denotes |
the |
T13042 |
1209-1211 |
CC |
denotes |
or |
T13041 |
1234-1242 |
VBN |
denotes |
required |
T13040 |
1205-1208 |
CD |
denotes |
one |
T13039 |
1201-1204 |
CC |
denotes |
and |
T13038 |
1199-1201 |
, |
denotes |
, |
T13037 |
1190-1199 |
JJ |
denotes |
redundant |
T13036 |
1177-1178 |
HYPH |
denotes |
- |
T13035 |
1176-1177 |
NN |
denotes |
m |
T13034 |
1172-1175 |
CC |
denotes |
and |
T13033 |
1170-1171 |
HYPH |
denotes |
- |
T13032 |
1178-1185 |
NN |
denotes |
calpain |
T13031 |
1169-1170 |
NN |
denotes |
μ |
T13030 |
1167-1168 |
-RRB- |
denotes |
) |
T13029 |
1186-1189 |
VBP |
denotes |
are |
T13028 |
1166-1167 |
LS |
denotes |
4 |
T13027 |
1163-1165 |
CC |
denotes |
or |
T13026 |
1161-1163 |
, |
denotes |
, |
T13025 |
1149-1152 |
VBD |
denotes |
was |
T13024 |
1140-1141 |
HYPH |
denotes |
- |
T13023 |
1141-1148 |
NN |
denotes |
calpain |
T13022 |
1139-1140 |
NN |
denotes |
m |
T13021 |
1137-1138 |
-RRB- |
denotes |
) |
T13020 |
1153-1161 |
VBN |
denotes |
required |
T13019 |
1136-1137 |
LS |
denotes |
3 |
T13018 |
1134-1135 |
: |
denotes |
; |
T13017 |
1122-1125 |
VBD |
denotes |
was |
T13016 |
1113-1114 |
HYPH |
denotes |
- |
T13015 |
1114-1121 |
NN |
denotes |
calpain |
T13014 |
1112-1113 |
NN |
denotes |
μ |
T13013 |
1110-1111 |
-RRB- |
denotes |
) |
T13012 |
1126-1134 |
VBN |
denotes |
required |
T13011 |
1109-1110 |
LS |
denotes |
2 |
T13010 |
1107-1108 |
: |
denotes |
; |
T13009 |
1094-1098 |
VBD |
denotes |
were |
T13008 |
1085-1093 |
NNS |
denotes |
isoforms |
T13007 |
1080-1084 |
DT |
denotes |
both |
T13006 |
1078-1079 |
-RRB- |
denotes |
) |
T13005 |
1077-1078 |
LS |
denotes |
1 |
T13004 |
1075-1077 |
: |
denotes |
: |
T13003 |
1064-1075 |
NN |
denotes |
development |
T13002 |
1054-1063 |
JJ |
denotes |
embryonic |
T13001 |
1050-1053 |
IN |
denotes |
for |
T13000 |
1038-1049 |
NN |
denotes |
requirement |
T12999 |
1032-1037 |
PRP$ |
denotes |
their |
T12998 |
1022-1031 |
VBG |
denotes |
regarding |
T12997 |
1008-1021 |
NNS |
denotes |
possibilities |
T12996 |
1003-1007 |
CD |
denotes |
four |
T12995 |
993-1002 |
VBD |
denotes |
suggested |
T12994 |
981-992 |
RB |
denotes |
furthermore |
T12993 |
977-980 |
CC |
denotes |
and |
T12992 |
975-977 |
, |
denotes |
, |
T12991 |
967-968 |
HYPH |
denotes |
- |
T12990 |
966-967 |
NN |
denotes |
m |
T12989 |
962-965 |
CC |
denotes |
and |
T12988 |
960-961 |
HYPH |
denotes |
- |
T12987 |
959-960 |
NN |
denotes |
μ |
T12986 |
968-975 |
NN |
denotes |
calpain |
T12985 |
954-958 |
CC |
denotes |
both |
T12984 |
950-953 |
IN |
denotes |
for |
T12983 |
938-940 |
VBZ |
denotes |
is |
T12982 |
924-929 |
JJ |
denotes |
small |
T12981 |
930-937 |
NN |
denotes |
subunit |
T12980 |
920-923 |
DT |
denotes |
the |
T12979 |
941-949 |
VBN |
denotes |
required |
T12978 |
915-919 |
IN |
denotes |
that |
T12977 |
904-914 |
NN |
denotes |
hypothesis |
T12976 |
900-903 |
DT |
denotes |
the |
T12975 |
1099-1107 |
VBN |
denotes |
required |
T12974 |
890-899 |
VBD |
denotes |
supported |
T12973 |
877-889 |
NNS |
denotes |
observations |
T12972 |
871-876 |
DT |
denotes |
These |
T12971 |
870-1243 |
sentence |
denotes |
These observations supported the hypothesis that the small subunit is required for both μ- and m-calpain, and furthermore suggested four possibilities regarding their requirement for embryonic development: 1) both isoforms were required; 2) μ-calpain was required; 3) m-calpain was required, or 4) μ- and m-calpain are redundant, and one or the other isoform was required. |
T12970 |
869-870 |
. |
denotes |
. |
T12969 |
868-869 |
-RRB- |
denotes |
] |
T12968 |
865-866 |
, |
denotes |
, |
T12967 |
863-865 |
CD |
denotes |
31 |
T12966 |
866-868 |
CD |
denotes |
32 |
T12965 |
862-863 |
-LRB- |
denotes |
[ |
T12964 |
850-861 |
NN |
denotes |
development |
T12963 |
847-849 |
IN |
denotes |
of |
T12962 |
840-846 |
NNS |
denotes |
stages |
T12961 |
830-839 |
JJ |
denotes |
different |
T12960 |
827-829 |
IN |
denotes |
at |
T12959 |
820-826 |
IN |
denotes |
albeit |
T12958 |
818-820 |
, |
denotes |
, |
R2370 |
T12875 |
T12876 |
det |
the,story |
R2373 |
T12816 |
T12817 |
mark |
Although,identified |
R2374 |
T12876 |
T12870 |
nsubjpass |
story,complicated |
R2375 |
T12877 |
T12870 |
aux |
has,complicated |
R2376 |
T12817 |
T12822 |
advcl |
identified,remained |
R2377 |
T12818 |
T12819 |
compound |
calpain,activity |
R2378 |
T12878 |
T12870 |
auxpass |
been,complicated |
R2379 |
T12819 |
T12817 |
nsubjpass |
activity,identified |
R2380 |
T12820 |
T12817 |
auxpass |
was,identified |
R2381 |
T12821 |
T12817 |
advmod |
first,identified |
R2382 |
T12879 |
T12870 |
advmod |
further,complicated |
R2383 |
T12823 |
T12824 |
nummod |
four,decades |
R2384 |
T12880 |
T12870 |
agent |
by,complicated |
R2385 |
T12824 |
T12825 |
npadvmod |
decades,ago |
R2386 |
T12825 |
T12817 |
advmod |
ago,identified |
R2387 |
T12826 |
T12822 |
punct |
", ",remained |
R2388 |
T12881 |
T12882 |
det |
the,discovery |
R2389 |
T12827 |
T12828 |
det |
a,understanding |
R2390 |
T12828 |
T12822 |
nsubj |
understanding,remained |
R2391 |
T12882 |
T12880 |
pobj |
discovery,by |
R2392 |
T12829 |
T12828 |
amod |
clear,understanding |
R2393 |
T12830 |
T12828 |
prep |
of,understanding |
R2394 |
T12831 |
T12832 |
det |
the,substrates |
R2395 |
T12883 |
T12882 |
prep |
of,discovery |
R2396 |
T12884 |
T12885 |
det |
a,number |
R2397 |
T12832 |
T12830 |
pobj |
substrates,of |
R2398 |
T12885 |
T12883 |
pobj |
number,of |
R2399 |
T12833 |
T12832 |
cc |
and,substrates |
R2400 |
T12834 |
T12832 |
conj |
functions,substrates |
R2401 |
T12886 |
T12885 |
prep |
of,number |
R2402 |
T12835 |
T12832 |
prep |
of,substrates |
R2403 |
T12836 |
T12837 |
det |
the,enzymes |
R2404 |
T12887 |
T12888 |
advmod |
previously,unknown |
R2405 |
T12837 |
T12835 |
pobj |
enzymes,of |
R2406 |
T12838 |
T12822 |
aux |
has,remained |
R2407 |
T12839 |
T12822 |
acomp |
elusive,remained |
R2408 |
T12840 |
T12822 |
punct |
.,remained |
R2409 |
T12842 |
T12843 |
prep |
In,been |
R2410 |
T12844 |
T12845 |
amod |
large,part |
R2411 |
T12845 |
T12842 |
pobj |
part,In |
R2412 |
T12846 |
T12843 |
punct |
", ",been |
R2413 |
T12847 |
T12843 |
nsubj |
this,been |
R2414 |
T12848 |
T12843 |
aux |
has,been |
R2415 |
T12849 |
T12843 |
prep |
due,been |
R2416 |
T12850 |
T12849 |
pcomp |
to,due |
R2417 |
T12888 |
T12889 |
amod |
unknown,isoforms |
R2418 |
T12851 |
T12852 |
det |
the,lack |
R2419 |
T12852 |
T12849 |
pobj |
lack,due |
R2420 |
T12853 |
T12852 |
prep |
of,lack |
R2421 |
T12854 |
T12853 |
pobj |
inhibitors,of |
R2422 |
T12855 |
T12854 |
amod |
capable,inhibitors |
R2423 |
T12856 |
T12855 |
prep |
of,capable |
R2424 |
T12889 |
T12886 |
pobj |
isoforms,of |
R2425 |
T12857 |
T12858 |
advmod |
specifically,regulating |
R2426 |
T12858 |
T12856 |
pcomp |
regulating,of |
R2427 |
T12859 |
T12858 |
advmod |
down,regulating |
R2428 |
T12890 |
T12891 |
dep |
which,regulated |
R2429 |
T12860 |
T12858 |
punct |
-,regulating |
R2430 |
T12861 |
T12862 |
det |
the,calpains |
R2431 |
T12862 |
T12858 |
dobj |
calpains,regulating |
R2432 |
T12891 |
T12889 |
relcl |
regulated,isoforms |
R2433 |
T12863 |
T12858 |
prep |
without,regulating |
R2434 |
T12864 |
T12863 |
pcomp |
affecting,without |
R2435 |
T12865 |
T12866 |
amod |
other,proteases |
R2436 |
T12892 |
T12891 |
aux |
may,regulated |
R2437 |
T12866 |
T12864 |
dobj |
proteases,affecting |
R2438 |
T12867 |
T12843 |
punct |
.,been |
R2439 |
T12893 |
T12891 |
auxpass |
be,regulated |
R2440 |
T12869 |
T12870 |
prep |
In,complicated |
R2441 |
T12894 |
T12891 |
advmod |
differently,regulated |
R2442 |
T12871 |
T12872 |
det |
the,decade |
R2443 |
T12872 |
T12869 |
pobj |
decade,In |
R2444 |
T12873 |
T12872 |
amod |
past,decade |
R2445 |
T12895 |
T12891 |
cc |
and,regulated |
R2446 |
T12874 |
T12870 |
punct |
", ",complicated |
R2447 |
T12896 |
T12891 |
conj |
have,regulated |
R2448 |
T12897 |
T12898 |
amod |
different,specificity |
R2449 |
T12898 |
T12896 |
dobj |
specificity,have |
R2450 |
T12899 |
T12898 |
compound |
substrate,specificity |
R2451 |
T12981 |
T12979 |
nsubjpass |
subunit,required |
R2452 |
T12900 |
T12870 |
punct |
.,complicated |
R2453 |
T12982 |
T12981 |
amod |
small,subunit |
R2454 |
T12983 |
T12979 |
auxpass |
is,required |
R2455 |
T12902 |
T12903 |
compound |
Gene,targeting |
R2456 |
T12984 |
T12979 |
prep |
for,required |
R2457 |
T12985 |
T12986 |
preconj |
both,calpain |
R2458 |
T12903 |
T12904 |
nsubj |
targeting,provided |
R2459 |
T12905 |
T12903 |
prep |
in,targeting |
R2460 |
T12986 |
T12984 |
pobj |
calpain,for |
R2461 |
T12987 |
T12986 |
nmod |
μ,calpain |
R2462 |
T12988 |
T12987 |
punct |
-,μ |
R2463 |
T12989 |
T12987 |
cc |
and,μ |
R2464 |
T12990 |
T12987 |
conj |
m,μ |
R2465 |
T12991 |
T12986 |
punct |
-,calpain |
R2466 |
T12992 |
T12974 |
punct |
", ",supported |
R2467 |
T12993 |
T12974 |
cc |
and,supported |
R2468 |
T12994 |
T12995 |
advmod |
furthermore,suggested |
R2469 |
T12906 |
T12905 |
pobj |
mice,in |
R2470 |
T12995 |
T12974 |
conj |
suggested,supported |
R2471 |
T12996 |
T12997 |
nummod |
four,possibilities |
R2472 |
T12997 |
T12995 |
dobj |
possibilities,suggested |
R2473 |
T12907 |
T12904 |
aux |
has,provided |
R2474 |
T12998 |
T12997 |
prep |
regarding,possibilities |
R2475 |
T12999 |
T13000 |
poss |
their,requirement |
R2476 |
T13000 |
T12998 |
pobj |
requirement,regarding |
R2477 |
T12908 |
T12909 |
det |
a,approach |
R2478 |
T13001 |
T13000 |
prep |
for,requirement |
R2479 |
T13002 |
T13003 |
amod |
embryonic,development |
R2480 |
T13003 |
T13001 |
pobj |
development,for |
R2481 |
T12909 |
T12904 |
dobj |
approach,provided |
R2482 |
T13004 |
T12975 |
punct |
: ,required |
R2483 |
T13005 |
T12975 |
meta |
1,required |
R2484 |
T13006 |
T13005 |
punct |
),1 |
R2485 |
T12910 |
T12909 |
amod |
powerful,approach |
R2486 |
T13007 |
T13008 |
det |
both,isoforms |
R2487 |
T13008 |
T12975 |
nsubjpass |
isoforms,required |
R2488 |
T12911 |
T12912 |
aux |
to,examine |
R2489 |
T13009 |
T12975 |
auxpass |
were,required |
R2490 |
T13010 |
T12975 |
punct |
;,required |
R2491 |
T13011 |
T13012 |
meta |
2,required |
R2492 |
T13012 |
T12975 |
conj |
required,required |
R2493 |
T13013 |
T13011 |
punct |
),2 |
R2494 |
T12912 |
T12909 |
advcl |
examine,approach |
R2495 |
T13014 |
T13015 |
compound |
μ,calpain |
R2496 |
T13015 |
T13012 |
nsubjpass |
calpain,required |
R2497 |
T13016 |
T13015 |
punct |
-,calpain |
R2498 |
T12913 |
T12914 |
det |
the,roles |
R2499 |
T13017 |
T13012 |
auxpass |
was,required |
R2500 |
T13018 |
T13012 |
punct |
;,required |
R2501 |
T13019 |
T13020 |
meta |
3,required |
R2502 |
T12914 |
T12912 |
dobj |
roles,examine |
R2503 |
T13020 |
T13012 |
conj |
required,required |
R2504 |
T13021 |
T13019 |
punct |
),3 |
R2505 |
T13022 |
T13023 |
compound |
m,calpain |
R2506 |
T12915 |
T12914 |
amod |
physiologic,roles |
R2507 |
T13023 |
T13020 |
nsubjpass |
calpain,required |
R2508 |
T13024 |
T13023 |
punct |
-,calpain |
R2509 |
T13025 |
T13020 |
auxpass |
was,required |
R2510 |
T12916 |
T12914 |
prep |
of,roles |
R2511 |
T13026 |
T13020 |
punct |
", ",required |
R2512 |
T13027 |
T13020 |
cc |
or,required |
R2513 |
T13028 |
T13029 |
meta |
4,are |
R2514 |
T13029 |
T13020 |
conj |
are,required |
R2515 |
T13030 |
T13028 |
punct |
),4 |
R2516 |
T13031 |
T13032 |
nmod |
μ,calpain |
R2517 |
T13032 |
T13029 |
nsubj |
calpain,are |
R2518 |
T13033 |
T13031 |
punct |
-,μ |
R2519 |
T12917 |
T12918 |
amod |
individual,isoforms |
R2520 |
T13034 |
T13031 |
cc |
and,μ |
R2521 |
T13035 |
T13031 |
conj |
m,μ |
R2522 |
T13036 |
T13032 |
punct |
-,calpain |
R2523 |
T12918 |
T12916 |
pobj |
isoforms,of |
R2524 |
T13037 |
T13029 |
acomp |
redundant,are |
R2525 |
T13038 |
T13029 |
punct |
", ",are |
R2526 |
T13039 |
T13029 |
cc |
and,are |
R2527 |
T12919 |
T12918 |
compound |
calpain,isoforms |
R2528 |
T13040 |
T13041 |
nsubjpass |
one,required |
R2529 |
T13041 |
T13029 |
conj |
required,are |
R2530 |
T13042 |
T13040 |
cc |
or,one |
R2531 |
T12920 |
T12904 |
punct |
.,provided |
R2532 |
T13043 |
T13044 |
det |
the,other |
R2533 |
T13044 |
T13045 |
nmod |
other,isoform |
R2534 |
T13045 |
T13040 |
conj |
isoform,one |
R2535 |
T12922 |
T12923 |
nsubjpass |
This,used |
R2536 |
T13046 |
T13041 |
auxpass |
was,required |
R2537 |
T13047 |
T12975 |
punct |
.,required |
R2538 |
T13049 |
T13050 |
det |
These,options |
R2539 |
T12924 |
T12923 |
auxpass |
was,used |
R2540 |
T13050 |
T13051 |
nsubjpass |
options,narrowed |
R2541 |
T13052 |
T13051 |
auxpass |
were,narrowed |
R2542 |
T13053 |
T13051 |
prt |
down,narrowed |
R2543 |
T13054 |
T13051 |
agent |
by,narrowed |
R2544 |
T12925 |
T12923 |
advmod |
first,used |
R2545 |
T13055 |
T13056 |
det |
the,observation |
R2546 |
T13056 |
T13054 |
pobj |
observation,by |
R2547 |
T13057 |
T13056 |
amod |
subsequent,observation |
R2548 |
T13058 |
T13059 |
mark |
that,were |
R2549 |
T12926 |
T12927 |
aux |
to,disrupt |
R2550 |
T12927 |
T12923 |
advcl |
disrupt,used |
R2551 |
T13059 |
T13056 |
acl |
were,observation |
R2552 |
T12928 |
T12929 |
det |
the,gene |
R2553 |
T13060 |
T13061 |
nmod |
Capn1,mice |
R2554 |
T13061 |
T13059 |
nsubj |
mice,were |
R2555 |
T13062 |
T13060 |
punct |
-,Capn1 |
R2556 |
T13063 |
T13060 |
punct |
/,Capn1 |
R2557 |
T12929 |
T12927 |
dobj |
gene,disrupt |
R2558 |
T13064 |
T13060 |
punct |
-,Capn1 |
R2559 |
T13065 |
T13061 |
punct |
", ",mice |
R2560 |
T12930 |
T12929 |
compound |
Capn4,gene |
R2561 |
T13066 |
T13067 |
dep |
which,lack |
R2562 |
T13067 |
T13061 |
relcl |
lack,mice |
R2563 |
T13068 |
T13069 |
det |
the,subunit |
R2564 |
T13069 |
T13067 |
dobj |
subunit,lack |
R2565 |
T13070 |
T13071 |
nmod |
μ,calpain |
R2566 |
T13071 |
T13069 |
nmod |
calpain,subunit |
R2567 |
T13072 |
T13071 |
punct |
-,calpain |
R2568 |
T13073 |
T13069 |
amod |
catalytic,subunit |
R2569 |
T13074 |
T13059 |
punct |
", ",were |
R2570 |
T13075 |
T13059 |
acomp |
healthy,were |
R2571 |
T13076 |
T13075 |
cc |
and,healthy |
R2572 |
T12931 |
T12923 |
punct |
", ",used |
R2573 |
T13077 |
T13075 |
conj |
fertile,healthy |
R2574 |
T13078 |
T13059 |
punct |
", ",were |
R2575 |
T13079 |
T13080 |
mark |
although,observed |
R2576 |
T12932 |
T12923 |
advcl |
encoding,used |
R2577 |
T13080 |
T13059 |
advcl |
observed,were |
R2578 |
T13081 |
T13082 |
nmod |
platelet,aggregation |
R2579 |
T12933 |
T12934 |
det |
the,subunit |
R2580 |
T13082 |
T13083 |
nmod |
aggregation,defects |
R2581 |
T13083 |
T13080 |
nsubjpass |
defects,observed |
R2582 |
T13084 |
T13082 |
cc |
and,aggregation |
R2583 |
T13085 |
T13086 |
compound |
clot,retraction |
R2584 |
T12934 |
T12932 |
dobj |
subunit,encoding |
R2585 |
T13086 |
T13082 |
conj |
retraction,aggregation |
R2586 |
T12935 |
T12934 |
amod |
small,subunit |
R2587 |
T12936 |
T12934 |
amod |
regulatory,subunit |
R2588 |
T12937 |
T12934 |
amod |
common,subunit |
R2589 |
T13087 |
T13080 |
auxpass |
were,observed |
R2590 |
T12938 |
T12937 |
prep |
to,common |
R2591 |
T13088 |
T13089 |
punct |
[,33 |
R2592 |
T13089 |
T13059 |
parataxis |
33,were |
R2593 |
T13090 |
T13089 |
punct |
],33 |
R2594 |
T12939 |
T12940 |
preconj |
both,calpain |
R2595 |
T13091 |
T13051 |
punct |
.,narrowed |
R2596 |
T12940 |
T12938 |
pobj |
calpain,to |
R2597 |
T13093 |
T13094 |
prep |
At,left |
R2598 |
T13095 |
T13096 |
det |
that,point |
R2599 |
T12941 |
T12940 |
nmod |
μ,calpain |
R2600 |
T13096 |
T13093 |
pobj |
point,At |
R2601 |
T13097 |
T13094 |
punct |
", ",left |
R2602 |
T13098 |
T13094 |
nsubjpass |
we,left |
R2603 |
T12942 |
T12941 |
punct |
-,μ |
R2604 |
T13099 |
T13094 |
auxpass |
were,left |
R2605 |
T13100 |
T13094 |
prep |
with,left |
R2606 |
T13101 |
T13102 |
det |
the,possibilities |
R2607 |
T12943 |
T12941 |
cc |
and,μ |
R2608 |
T13102 |
T13100 |
pobj |
possibilities,with |
R2609 |
T13103 |
T13102 |
amod |
last,possibilities |
R2610 |
T13104 |
T13102 |
nummod |
two,possibilities |
R2611 |
T12944 |
T12941 |
conj |
m,μ |
R2612 |
T13105 |
T13106 |
mark |
that,required |
R2613 |
T13106 |
T13102 |
advcl |
required,possibilities |
R2614 |
T13107 |
T13108 |
det |
either,calpain |
R2615 |
T13108 |
T13106 |
nsubjpass |
calpain,required |
R2616 |
T13109 |
T13108 |
compound |
m,calpain |
R2617 |
T13110 |
T13108 |
punct |
-,calpain |
R2618 |
T13111 |
T13106 |
auxpass |
was,required |
R2619 |
T13112 |
T13106 |
advmod |
specifically,required |
R2620 |
T13113 |
T13106 |
prep |
during,required |
R2621 |
T12945 |
T12940 |
punct |
-,calpain |
R2622 |
T13114 |
T13113 |
pobj |
embryogenesis,during |
R2623 |
T13115 |
T13106 |
punct |
", ",required |
R2624 |
T13116 |
T13106 |
cc |
or,required |
R2625 |
T13117 |
T13118 |
mark |
that,was |
R2626 |
T12946 |
T12923 |
punct |
.,used |
R2627 |
T13118 |
T13106 |
conj |
was,required |
R2628 |
T13119 |
T13120 |
det |
either,isoform |
R2629 |
T13120 |
T13118 |
nsubj |
isoform,was |
R2630 |
T13121 |
T13120 |
advmod |
alone,isoform |
R2631 |
T13122 |
T13118 |
acomp |
sufficient,was |
R2632 |
T12948 |
T12949 |
nummod |
Two,laboratories |
R2633 |
T13123 |
T13122 |
prep |
for,sufficient |
R2634 |
T13124 |
T13123 |
pcomp |
sustaining,for |
R2635 |
T13125 |
T13126 |
amod |
embryonic,viability |
R2636 |
T12949 |
T12951 |
nsubj |
laboratories,observed |
R2637 |
T13126 |
T13124 |
dobj |
viability,sustaining |
R2638 |
T13127 |
T13094 |
punct |
.,left |
R2640 |
T12950 |
T12949 |
amod |
independent,laboratories |
R2643 |
T12952 |
T12953 |
amod |
embryonic,lethality |
R2650 |
T12953 |
T12951 |
dobj |
lethality,observed |
R2654 |
T12954 |
T12951 |
prep |
in,observed |
R2658 |
T12955 |
T12956 |
compound |
Capn4,mice |
R2662 |
T12956 |
T12954 |
pobj |
mice,in |
R2666 |
T12957 |
T12956 |
compound |
knockout,mice |
R2672 |
T12958 |
T12951 |
punct |
", ",observed |
R2674 |
T12959 |
T12960 |
dep |
albeit,at |
R2675 |
T12960 |
T12951 |
prep |
at,observed |
R2677 |
T12961 |
T12962 |
amod |
different,stages |
R2680 |
T12962 |
T12960 |
pobj |
stages,at |
R2684 |
T12963 |
T12962 |
prep |
of,stages |
R2687 |
T12964 |
T12963 |
pobj |
development,of |
R2691 |
T12965 |
T12966 |
punct |
[,32 |
R2695 |
T12966 |
T12951 |
parataxis |
32,observed |
R2697 |
T12967 |
T12966 |
nummod |
31,32 |
R2701 |
T12968 |
T12966 |
punct |
",",32 |
R2703 |
T12969 |
T12966 |
punct |
],32 |
R2707 |
T12970 |
T12951 |
punct |
.,observed |
R2710 |
T12972 |
T12973 |
det |
These,observations |
R2714 |
T12973 |
T12974 |
nsubj |
observations,supported |
R2718 |
T12974 |
T12975 |
ccomp |
supported,required |
R2721 |
T12976 |
T12977 |
det |
the,hypothesis |
R2724 |
T12977 |
T12974 |
dobj |
hypothesis,supported |
R2726 |
T12978 |
T12979 |
mark |
that,required |
R2732 |
T12979 |
T12977 |
acl |
required,hypothesis |
R2736 |
T12980 |
T12981 |
det |
the,subunit |