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PMC:1382200 / 16457-18141 JSONTXT

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Id Subject Object Predicate Lexical cue
T13127 1683-1684 . denotes .
T13126 1674-1683 NN denotes viability
T13125 1664-1673 JJ denotes embryonic
T13124 1653-1663 VBG denotes sustaining
T13123 1649-1652 IN denotes for
T13122 1638-1648 JJ denotes sufficient
T13121 1628-1633 RB denotes alone
T13120 1620-1627 NN denotes isoform
T13119 1613-1619 DT denotes either
T13118 1634-1637 VBD denotes was
T13117 1608-1612 IN denotes that
T13116 1605-1607 CC denotes or
T13115 1603-1605 , denotes ,
T13114 1590-1603 NN denotes embryogenesis
T13113 1583-1589 IN denotes during
T13112 1561-1573 RB denotes specifically
T13111 1557-1560 VBD denotes was
T13110 1548-1549 HYPH denotes -
T13109 1547-1548 NN denotes m
T13108 1549-1556 NN denotes calpain
T13107 1540-1546 DT denotes either
T13106 1574-1582 VBN denotes required
T13105 1535-1539 IN denotes that
T13104 1517-1520 CD denotes two
T13103 1512-1516 JJ denotes last
T13102 1521-1534 NNS denotes possibilities
T13101 1508-1511 DT denotes the
T13100 1503-1507 IN denotes with
T13099 1493-1497 VBD denotes were
T13098 1490-1492 PRP denotes we
T13097 1488-1490 , denotes ,
T13096 1483-1488 NN denotes point
T13095 1478-1482 DT denotes that
T13094 1498-1502 VBN denotes left
T13093 1475-1477 IN denotes At
T13092 1474-1684 sentence denotes At that point, we were left with the last two possibilities that either m-calpain was specifically required during embryogenesis, or that either isoform alone was sufficient for sustaining embryonic viability.
T13091 1473-1474 . denotes .
T13090 1472-1473 -RRB- denotes ]
T13089 1470-1472 CD denotes 33
T13088 1469-1470 -LRB- denotes [
T13087 1455-1459 VBD denotes were
T13086 1436-1446 NN denotes retraction
T13085 1431-1435 NN denotes clot
T13084 1427-1430 CC denotes and
T13083 1447-1454 NNS denotes defects
T13082 1415-1426 NN denotes aggregation
T13081 1406-1414 NN denotes platelet
T13080 1460-1468 VBN denotes observed
T13079 1397-1405 IN denotes although
T13078 1395-1397 , denotes ,
T13077 1388-1395 JJ denotes fertile
T13076 1384-1387 CC denotes and
T13075 1376-1383 JJ denotes healthy
T13074 1369-1371 , denotes ,
T13073 1352-1361 JJ denotes catalytic
T13072 1343-1344 HYPH denotes -
T13071 1344-1351 NN denotes calpain
T13070 1342-1343 NN denotes μ
T13069 1362-1369 NN denotes subunit
T13068 1338-1341 DT denotes the
T13067 1333-1337 VBP denotes lack
T12957 805-813 NN denotes knockout
T12956 814-818 NNS denotes mice
T12955 799-804 NN denotes Capn4
T12954 796-798 IN denotes in
T12953 786-795 NN denotes lethality
T12952 776-785 JJ denotes embryonic
T12951 767-775 VBD denotes observed
T12950 742-753 JJ denotes independent
T12949 754-766 NNS denotes laboratories
T12948 738-741 CD denotes Two
T12947 737-870 sentence denotes Two independent laboratories observed embryonic lethality in Capn4 knockout mice, albeit at different stages of development [31,32].
T12946 736-737 . denotes .
T12945 728-729 HYPH denotes -
T12944 727-728 NN denotes m
T12943 723-726 CC denotes and
T12942 721-722 HYPH denotes -
T12941 720-721 NN denotes μ
T12940 729-736 NN denotes calpain
T12939 715-719 CC denotes both
T12938 712-714 IN denotes to
T12937 705-711 JJ denotes common
T12936 686-696 JJ denotes regulatory
T12935 680-685 JJ denotes small
T12934 697-704 NN denotes subunit
T12933 676-679 DT denotes the
T12932 667-675 VBG denotes encoding
T12931 665-667 , denotes ,
T12930 655-660 NN denotes Capn4
T12929 661-665 NN denotes gene
T12928 651-654 DT denotes the
T12927 643-650 VB denotes disrupt
T12926 640-642 TO denotes to
T12925 629-634 RB denotes first
T12924 625-628 VBD denotes was
T12923 635-639 VBN denotes used
T12922 620-624 DT denotes This
T12921 619-737 sentence denotes This was first used to disrupt the Capn4 gene, encoding the small regulatory subunit common to both μ- and m-calpain.
T12920 618-619 . denotes .
T12919 602-609 NN denotes calpain
T12918 610-618 NNS denotes isoforms
T12917 591-601 JJ denotes individual
T12916 588-590 IN denotes of
T12915 570-581 JJ denotes physiologic
T12914 582-587 NNS denotes roles
T12913 566-569 DT denotes the
T12912 558-565 VB denotes examine
T12911 555-557 TO denotes to
T12910 537-545 JJ denotes powerful
T12909 546-554 NN denotes approach
T12908 535-536 DT denotes a
T12907 522-525 VBZ denotes has
T12906 517-521 NNS denotes mice
T12905 514-516 IN denotes in
T12904 526-534 VBN denotes provided
T12903 504-513 NN denotes targeting
T12902 499-503 NN denotes Gene
T12901 498-619 sentence denotes Gene targeting in mice has provided a powerful approach to examine the physiologic roles of individual calpain isoforms.
T12900 497-498 . denotes .
T12899 476-485 NN denotes substrate
T12898 486-497 NN denotes specificity
T12897 466-475 JJ denotes different
T12896 461-465 VBP denotes have
T12895 457-460 CC denotes and
T12894 435-446 RB denotes differently
T12893 432-434 VB denotes be
T12892 428-431 MD denotes may
T12891 447-456 VBN denotes regulated
T12890 422-427 WDT denotes which
T12889 413-421 NNS denotes isoforms
T12888 405-412 JJ denotes unknown
T12887 394-404 RB denotes previously
T12886 391-393 IN denotes of
T12885 384-390 NN denotes number
T12884 382-383 DT denotes a
T12883 379-381 IN denotes of
T12882 369-378 NN denotes discovery
T12881 365-368 DT denotes the
T12880 362-364 IN denotes by
T12879 342-349 RB denotes further
T12878 337-341 VBN denotes been
T12877 333-336 VBZ denotes has
T12876 327-332 NN denotes story
T12875 323-326 DT denotes the
T12874 321-323 , denotes ,
T12873 310-314 JJ denotes past
T12872 315-321 NN denotes decade
T12871 306-309 DT denotes the
T12870 350-361 VBN denotes complicated
T12869 303-305 IN denotes In
T12868 302-498 sentence denotes In the past decade, the story has been further complicated by the discovery of a number of previously unknown isoforms which may be differently regulated and have different substrate specificity.
T12867 301-302 . denotes .
T12866 292-301 NNS denotes proteases
T12865 286-291 JJ denotes other
T12864 276-285 VBG denotes affecting
T12863 268-275 IN denotes without
T12862 259-267 NNS denotes calpains
T12861 255-258 DT denotes the
T12860 243-244 HYPH denotes -
T12859 239-243 RB denotes down
T12858 244-254 VBG denotes regulating
T12857 226-238 RB denotes specifically
T12856 223-225 IN denotes of
T12855 215-222 JJ denotes capable
T12854 204-214 NNS denotes inhibitors
T12853 201-203 IN denotes of
T12852 196-200 NN denotes lack
T12851 192-195 DT denotes the
T12850 189-191 IN denotes to
T12849 185-188 IN denotes due
T12848 176-179 VBZ denotes has
T12847 171-175 DT denotes this
T12846 169-171 , denotes ,
T12845 165-169 NN denotes part
T12844 159-164 JJ denotes large
T12843 180-184 VBN denotes been
T12842 156-158 IN denotes In
T12841 155-302 sentence denotes In large part, this has been due to the lack of inhibitors capable of specifically down-regulating the calpains without affecting other proteases.
T12840 154-155 . denotes .
T12839 147-154 JJ denotes elusive
T12838 134-137 VBZ denotes has
T12837 126-133 NNS denotes enzymes
T12836 122-125 DT denotes the
T12835 119-121 IN denotes of
T12834 109-118 NNS denotes functions
T12833 105-108 CC denotes and
T12832 94-104 NNS denotes substrates
T12831 90-93 DT denotes the
T12830 87-89 IN denotes of
T12829 67-72 JJ denotes clear
T12828 73-86 NN denotes understanding
T12827 65-66 DT denotes a
T12826 63-65 , denotes ,
T12825 60-63 RB denotes ago
T12824 52-59 NNS denotes decades
T12823 47-51 CD denotes four
T12822 138-146 VBN denotes remained
T12821 30-35 RB denotes first
T12820 26-29 VBD denotes was
T12819 17-25 NN denotes activity
T12818 9-16 NN denotes calpain
T12817 36-46 VBN denotes identified
T12816 0-8 IN denotes Although
T13066 1327-1332 WDT denotes which
T13065 1325-1327 , denotes ,
T13064 1319-1320 SYM denotes -
T13063 1318-1319 HYPH denotes /
T13062 1317-1318 SYM denotes -
T13061 1321-1325 NNS denotes mice
T13060 1312-1317 NN denotes Capn1
T13059 1371-1375 VBD denotes were
T13058 1307-1311 IN denotes that
T13057 1284-1294 JJ denotes subsequent
T13056 1295-1306 NN denotes observation
T13055 1280-1283 DT denotes the
T13054 1277-1279 IN denotes by
T13053 1272-1276 RP denotes down
T13052 1258-1262 VBD denotes were
T13051 1263-1271 VBN denotes narrowed
T13050 1250-1257 NNS denotes options
T13049 1244-1249 DT denotes These
T13048 1243-1474 sentence denotes These options were narrowed down by the subsequent observation that Capn1-/- mice, which lack the μ-calpain catalytic subunit, were healthy and fertile, although platelet aggregation and clot retraction defects were observed [33].
T13047 1242-1243 . denotes .
T13046 1230-1233 VBD denotes was
T13045 1222-1229 NN denotes isoform
T13044 1216-1221 JJ denotes other
T13043 1212-1215 DT denotes the
T13042 1209-1211 CC denotes or
T13041 1234-1242 VBN denotes required
T13040 1205-1208 CD denotes one
T13039 1201-1204 CC denotes and
T13038 1199-1201 , denotes ,
T13037 1190-1199 JJ denotes redundant
T13036 1177-1178 HYPH denotes -
T13035 1176-1177 NN denotes m
T13034 1172-1175 CC denotes and
T13033 1170-1171 HYPH denotes -
T13032 1178-1185 NN denotes calpain
T13031 1169-1170 NN denotes μ
T13030 1167-1168 -RRB- denotes )
T13029 1186-1189 VBP denotes are
T13028 1166-1167 LS denotes 4
T13027 1163-1165 CC denotes or
T13026 1161-1163 , denotes ,
T13025 1149-1152 VBD denotes was
T13024 1140-1141 HYPH denotes -
T13023 1141-1148 NN denotes calpain
T13022 1139-1140 NN denotes m
T13021 1137-1138 -RRB- denotes )
T13020 1153-1161 VBN denotes required
T13019 1136-1137 LS denotes 3
T13018 1134-1135 : denotes ;
T13017 1122-1125 VBD denotes was
T13016 1113-1114 HYPH denotes -
T13015 1114-1121 NN denotes calpain
T13014 1112-1113 NN denotes μ
T13013 1110-1111 -RRB- denotes )
T13012 1126-1134 VBN denotes required
T13011 1109-1110 LS denotes 2
T13010 1107-1108 : denotes ;
T13009 1094-1098 VBD denotes were
T13008 1085-1093 NNS denotes isoforms
T13007 1080-1084 DT denotes both
T13006 1078-1079 -RRB- denotes )
T13005 1077-1078 LS denotes 1
T13004 1075-1077 : denotes :
T13003 1064-1075 NN denotes development
T13002 1054-1063 JJ denotes embryonic
T13001 1050-1053 IN denotes for
T13000 1038-1049 NN denotes requirement
T12999 1032-1037 PRP$ denotes their
T12998 1022-1031 VBG denotes regarding
T12997 1008-1021 NNS denotes possibilities
T12996 1003-1007 CD denotes four
T12995 993-1002 VBD denotes suggested
T12994 981-992 RB denotes furthermore
T12993 977-980 CC denotes and
T12992 975-977 , denotes ,
T12991 967-968 HYPH denotes -
T12990 966-967 NN denotes m
T12989 962-965 CC denotes and
T12988 960-961 HYPH denotes -
T12987 959-960 NN denotes μ
T12986 968-975 NN denotes calpain
T12985 954-958 CC denotes both
T12984 950-953 IN denotes for
T12983 938-940 VBZ denotes is
T12982 924-929 JJ denotes small
T12981 930-937 NN denotes subunit
T12980 920-923 DT denotes the
T12979 941-949 VBN denotes required
T12978 915-919 IN denotes that
T12977 904-914 NN denotes hypothesis
T12976 900-903 DT denotes the
T12975 1099-1107 VBN denotes required
T12974 890-899 VBD denotes supported
T12973 877-889 NNS denotes observations
T12972 871-876 DT denotes These
T12971 870-1243 sentence denotes These observations supported the hypothesis that the small subunit is required for both μ- and m-calpain, and furthermore suggested four possibilities regarding their requirement for embryonic development: 1) both isoforms were required; 2) μ-calpain was required; 3) m-calpain was required, or 4) μ- and m-calpain are redundant, and one or the other isoform was required.
T12970 869-870 . denotes .
T12969 868-869 -RRB- denotes ]
T12968 865-866 , denotes ,
T12967 863-865 CD denotes 31
T12966 866-868 CD denotes 32
T12965 862-863 -LRB- denotes [
T12964 850-861 NN denotes development
T12963 847-849 IN denotes of
T12962 840-846 NNS denotes stages
T12961 830-839 JJ denotes different
T12960 827-829 IN denotes at
T12959 820-826 IN denotes albeit
T12958 818-820 , denotes ,
R2370 T12875 T12876 det the,story
R2373 T12816 T12817 mark Although,identified
R2374 T12876 T12870 nsubjpass story,complicated
R2375 T12877 T12870 aux has,complicated
R2376 T12817 T12822 advcl identified,remained
R2377 T12818 T12819 compound calpain,activity
R2378 T12878 T12870 auxpass been,complicated
R2379 T12819 T12817 nsubjpass activity,identified
R2380 T12820 T12817 auxpass was,identified
R2381 T12821 T12817 advmod first,identified
R2382 T12879 T12870 advmod further,complicated
R2383 T12823 T12824 nummod four,decades
R2384 T12880 T12870 agent by,complicated
R2385 T12824 T12825 npadvmod decades,ago
R2386 T12825 T12817 advmod ago,identified
R2387 T12826 T12822 punct ", ",remained
R2388 T12881 T12882 det the,discovery
R2389 T12827 T12828 det a,understanding
R2390 T12828 T12822 nsubj understanding,remained
R2391 T12882 T12880 pobj discovery,by
R2392 T12829 T12828 amod clear,understanding
R2393 T12830 T12828 prep of,understanding
R2394 T12831 T12832 det the,substrates
R2395 T12883 T12882 prep of,discovery
R2396 T12884 T12885 det a,number
R2397 T12832 T12830 pobj substrates,of
R2398 T12885 T12883 pobj number,of
R2399 T12833 T12832 cc and,substrates
R2400 T12834 T12832 conj functions,substrates
R2401 T12886 T12885 prep of,number
R2402 T12835 T12832 prep of,substrates
R2403 T12836 T12837 det the,enzymes
R2404 T12887 T12888 advmod previously,unknown
R2405 T12837 T12835 pobj enzymes,of
R2406 T12838 T12822 aux has,remained
R2407 T12839 T12822 acomp elusive,remained
R2408 T12840 T12822 punct .,remained
R2409 T12842 T12843 prep In,been
R2410 T12844 T12845 amod large,part
R2411 T12845 T12842 pobj part,In
R2412 T12846 T12843 punct ", ",been
R2413 T12847 T12843 nsubj this,been
R2414 T12848 T12843 aux has,been
R2415 T12849 T12843 prep due,been
R2416 T12850 T12849 pcomp to,due
R2417 T12888 T12889 amod unknown,isoforms
R2418 T12851 T12852 det the,lack
R2419 T12852 T12849 pobj lack,due
R2420 T12853 T12852 prep of,lack
R2421 T12854 T12853 pobj inhibitors,of
R2422 T12855 T12854 amod capable,inhibitors
R2423 T12856 T12855 prep of,capable
R2424 T12889 T12886 pobj isoforms,of
R2425 T12857 T12858 advmod specifically,regulating
R2426 T12858 T12856 pcomp regulating,of
R2427 T12859 T12858 advmod down,regulating
R2428 T12890 T12891 dep which,regulated
R2429 T12860 T12858 punct -,regulating
R2430 T12861 T12862 det the,calpains
R2431 T12862 T12858 dobj calpains,regulating
R2432 T12891 T12889 relcl regulated,isoforms
R2433 T12863 T12858 prep without,regulating
R2434 T12864 T12863 pcomp affecting,without
R2435 T12865 T12866 amod other,proteases
R2436 T12892 T12891 aux may,regulated
R2437 T12866 T12864 dobj proteases,affecting
R2438 T12867 T12843 punct .,been
R2439 T12893 T12891 auxpass be,regulated
R2440 T12869 T12870 prep In,complicated
R2441 T12894 T12891 advmod differently,regulated
R2442 T12871 T12872 det the,decade
R2443 T12872 T12869 pobj decade,In
R2444 T12873 T12872 amod past,decade
R2445 T12895 T12891 cc and,regulated
R2446 T12874 T12870 punct ", ",complicated
R2447 T12896 T12891 conj have,regulated
R2448 T12897 T12898 amod different,specificity
R2449 T12898 T12896 dobj specificity,have
R2450 T12899 T12898 compound substrate,specificity
R2451 T12981 T12979 nsubjpass subunit,required
R2452 T12900 T12870 punct .,complicated
R2453 T12982 T12981 amod small,subunit
R2454 T12983 T12979 auxpass is,required
R2455 T12902 T12903 compound Gene,targeting
R2456 T12984 T12979 prep for,required
R2457 T12985 T12986 preconj both,calpain
R2458 T12903 T12904 nsubj targeting,provided
R2459 T12905 T12903 prep in,targeting
R2460 T12986 T12984 pobj calpain,for
R2461 T12987 T12986 nmod μ,calpain
R2462 T12988 T12987 punct -,μ
R2463 T12989 T12987 cc and,μ
R2464 T12990 T12987 conj m,μ
R2465 T12991 T12986 punct -,calpain
R2466 T12992 T12974 punct ", ",supported
R2467 T12993 T12974 cc and,supported
R2468 T12994 T12995 advmod furthermore,suggested
R2469 T12906 T12905 pobj mice,in
R2470 T12995 T12974 conj suggested,supported
R2471 T12996 T12997 nummod four,possibilities
R2472 T12997 T12995 dobj possibilities,suggested
R2473 T12907 T12904 aux has,provided
R2474 T12998 T12997 prep regarding,possibilities
R2475 T12999 T13000 poss their,requirement
R2476 T13000 T12998 pobj requirement,regarding
R2477 T12908 T12909 det a,approach
R2478 T13001 T13000 prep for,requirement
R2479 T13002 T13003 amod embryonic,development
R2480 T13003 T13001 pobj development,for
R2481 T12909 T12904 dobj approach,provided
R2482 T13004 T12975 punct : ,required
R2483 T13005 T12975 meta 1,required
R2484 T13006 T13005 punct ),1
R2485 T12910 T12909 amod powerful,approach
R2486 T13007 T13008 det both,isoforms
R2487 T13008 T12975 nsubjpass isoforms,required
R2488 T12911 T12912 aux to,examine
R2489 T13009 T12975 auxpass were,required
R2490 T13010 T12975 punct ;,required
R2491 T13011 T13012 meta 2,required
R2492 T13012 T12975 conj required,required
R2493 T13013 T13011 punct ),2
R2494 T12912 T12909 advcl examine,approach
R2495 T13014 T13015 compound μ,calpain
R2496 T13015 T13012 nsubjpass calpain,required
R2497 T13016 T13015 punct -,calpain
R2498 T12913 T12914 det the,roles
R2499 T13017 T13012 auxpass was,required
R2500 T13018 T13012 punct ;,required
R2501 T13019 T13020 meta 3,required
R2502 T12914 T12912 dobj roles,examine
R2503 T13020 T13012 conj required,required
R2504 T13021 T13019 punct ),3
R2505 T13022 T13023 compound m,calpain
R2506 T12915 T12914 amod physiologic,roles
R2507 T13023 T13020 nsubjpass calpain,required
R2508 T13024 T13023 punct -,calpain
R2509 T13025 T13020 auxpass was,required
R2510 T12916 T12914 prep of,roles
R2511 T13026 T13020 punct ", ",required
R2512 T13027 T13020 cc or,required
R2513 T13028 T13029 meta 4,are
R2514 T13029 T13020 conj are,required
R2515 T13030 T13028 punct ),4
R2516 T13031 T13032 nmod μ,calpain
R2517 T13032 T13029 nsubj calpain,are
R2518 T13033 T13031 punct -,μ
R2519 T12917 T12918 amod individual,isoforms
R2520 T13034 T13031 cc and,μ
R2521 T13035 T13031 conj m,μ
R2522 T13036 T13032 punct -,calpain
R2523 T12918 T12916 pobj isoforms,of
R2524 T13037 T13029 acomp redundant,are
R2525 T13038 T13029 punct ", ",are
R2526 T13039 T13029 cc and,are
R2527 T12919 T12918 compound calpain,isoforms
R2528 T13040 T13041 nsubjpass one,required
R2529 T13041 T13029 conj required,are
R2530 T13042 T13040 cc or,one
R2531 T12920 T12904 punct .,provided
R2532 T13043 T13044 det the,other
R2533 T13044 T13045 nmod other,isoform
R2534 T13045 T13040 conj isoform,one
R2535 T12922 T12923 nsubjpass This,used
R2536 T13046 T13041 auxpass was,required
R2537 T13047 T12975 punct .,required
R2538 T13049 T13050 det These,options
R2539 T12924 T12923 auxpass was,used
R2540 T13050 T13051 nsubjpass options,narrowed
R2541 T13052 T13051 auxpass were,narrowed
R2542 T13053 T13051 prt down,narrowed
R2543 T13054 T13051 agent by,narrowed
R2544 T12925 T12923 advmod first,used
R2545 T13055 T13056 det the,observation
R2546 T13056 T13054 pobj observation,by
R2547 T13057 T13056 amod subsequent,observation
R2548 T13058 T13059 mark that,were
R2549 T12926 T12927 aux to,disrupt
R2550 T12927 T12923 advcl disrupt,used
R2551 T13059 T13056 acl were,observation
R2552 T12928 T12929 det the,gene
R2553 T13060 T13061 nmod Capn1,mice
R2554 T13061 T13059 nsubj mice,were
R2555 T13062 T13060 punct -,Capn1
R2556 T13063 T13060 punct /,Capn1
R2557 T12929 T12927 dobj gene,disrupt
R2558 T13064 T13060 punct -,Capn1
R2559 T13065 T13061 punct ", ",mice
R2560 T12930 T12929 compound Capn4,gene
R2561 T13066 T13067 dep which,lack
R2562 T13067 T13061 relcl lack,mice
R2563 T13068 T13069 det the,subunit
R2564 T13069 T13067 dobj subunit,lack
R2565 T13070 T13071 nmod μ,calpain
R2566 T13071 T13069 nmod calpain,subunit
R2567 T13072 T13071 punct -,calpain
R2568 T13073 T13069 amod catalytic,subunit
R2569 T13074 T13059 punct ", ",were
R2570 T13075 T13059 acomp healthy,were
R2571 T13076 T13075 cc and,healthy
R2572 T12931 T12923 punct ", ",used
R2573 T13077 T13075 conj fertile,healthy
R2574 T13078 T13059 punct ", ",were
R2575 T13079 T13080 mark although,observed
R2576 T12932 T12923 advcl encoding,used
R2577 T13080 T13059 advcl observed,were
R2578 T13081 T13082 nmod platelet,aggregation
R2579 T12933 T12934 det the,subunit
R2580 T13082 T13083 nmod aggregation,defects
R2581 T13083 T13080 nsubjpass defects,observed
R2582 T13084 T13082 cc and,aggregation
R2583 T13085 T13086 compound clot,retraction
R2584 T12934 T12932 dobj subunit,encoding
R2585 T13086 T13082 conj retraction,aggregation
R2586 T12935 T12934 amod small,subunit
R2587 T12936 T12934 amod regulatory,subunit
R2588 T12937 T12934 amod common,subunit
R2589 T13087 T13080 auxpass were,observed
R2590 T12938 T12937 prep to,common
R2591 T13088 T13089 punct [,33
R2592 T13089 T13059 parataxis 33,were
R2593 T13090 T13089 punct ],33
R2594 T12939 T12940 preconj both,calpain
R2595 T13091 T13051 punct .,narrowed
R2596 T12940 T12938 pobj calpain,to
R2597 T13093 T13094 prep At,left
R2598 T13095 T13096 det that,point
R2599 T12941 T12940 nmod μ,calpain
R2600 T13096 T13093 pobj point,At
R2601 T13097 T13094 punct ", ",left
R2602 T13098 T13094 nsubjpass we,left
R2603 T12942 T12941 punct -,μ
R2604 T13099 T13094 auxpass were,left
R2605 T13100 T13094 prep with,left
R2606 T13101 T13102 det the,possibilities
R2607 T12943 T12941 cc and,μ
R2608 T13102 T13100 pobj possibilities,with
R2609 T13103 T13102 amod last,possibilities
R2610 T13104 T13102 nummod two,possibilities
R2611 T12944 T12941 conj m,μ
R2612 T13105 T13106 mark that,required
R2613 T13106 T13102 advcl required,possibilities
R2614 T13107 T13108 det either,calpain
R2615 T13108 T13106 nsubjpass calpain,required
R2616 T13109 T13108 compound m,calpain
R2617 T13110 T13108 punct -,calpain
R2618 T13111 T13106 auxpass was,required
R2619 T13112 T13106 advmod specifically,required
R2620 T13113 T13106 prep during,required
R2621 T12945 T12940 punct -,calpain
R2622 T13114 T13113 pobj embryogenesis,during
R2623 T13115 T13106 punct ", ",required
R2624 T13116 T13106 cc or,required
R2625 T13117 T13118 mark that,was
R2626 T12946 T12923 punct .,used
R2627 T13118 T13106 conj was,required
R2628 T13119 T13120 det either,isoform
R2629 T13120 T13118 nsubj isoform,was
R2630 T13121 T13120 advmod alone,isoform
R2631 T13122 T13118 acomp sufficient,was
R2632 T12948 T12949 nummod Two,laboratories
R2633 T13123 T13122 prep for,sufficient
R2634 T13124 T13123 pcomp sustaining,for
R2635 T13125 T13126 amod embryonic,viability
R2636 T12949 T12951 nsubj laboratories,observed
R2637 T13126 T13124 dobj viability,sustaining
R2638 T13127 T13094 punct .,left
R2640 T12950 T12949 amod independent,laboratories
R2643 T12952 T12953 amod embryonic,lethality
R2650 T12953 T12951 dobj lethality,observed
R2654 T12954 T12951 prep in,observed
R2658 T12955 T12956 compound Capn4,mice
R2662 T12956 T12954 pobj mice,in
R2666 T12957 T12956 compound knockout,mice
R2672 T12958 T12951 punct ", ",observed
R2674 T12959 T12960 dep albeit,at
R2675 T12960 T12951 prep at,observed
R2677 T12961 T12962 amod different,stages
R2680 T12962 T12960 pobj stages,at
R2684 T12963 T12962 prep of,stages
R2687 T12964 T12963 pobj development,of
R2691 T12965 T12966 punct [,32
R2695 T12966 T12951 parataxis 32,observed
R2697 T12967 T12966 nummod 31,32
R2701 T12968 T12966 punct ",",32
R2703 T12969 T12966 punct ],32
R2707 T12970 T12951 punct .,observed
R2710 T12972 T12973 det These,observations
R2714 T12973 T12974 nsubj observations,supported
R2718 T12974 T12975 ccomp supported,required
R2721 T12976 T12977 det the,hypothesis
R2724 T12977 T12974 dobj hypothesis,supported
R2726 T12978 T12979 mark that,required
R2732 T12979 T12977 acl required,hypothesis
R2736 T12980 T12981 det the,subunit

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12223 1664-1673 UBERON:0000922 denotes embryonic
T12222 1620-1627 SO:0001060 denotes isoform
T12221 1590-1603 GO:0009790 denotes embryogenesis
T12220 1406-1426 GO:0070527 denotes platelet aggregation
T12219 1406-1414 CL:0000233 denotes platelet
T12218 1342-1369 PR:000005009 denotes μ-calpain catalytic subunit
T12217 1321-1325 NCBITaxon:10088 denotes mice
T12216 1312-1317 PR:000005009 denotes Capn1
T12215 1222-1229 SO:0001060 denotes isoform
T12214 1085-1093 SO:0001060 denotes isoforms
T12213 1054-1075 GO:0009790 denotes embryonic development
T12212 1054-1063 UBERON:0000922 denotes embryonic
T12211 814-818 NCBITaxon:10088 denotes mice
T12210 799-804 PR:000005022 denotes Capn4
T12209 776-785 UBERON:0000922 denotes embryonic
T12208 686-696 GO:0065007 denotes regulatory
T12207 661-665 SO:0000704 denotes gene
T12206 655-660 PR:000005022 denotes Capn4
T12205 610-618 SO:0001060 denotes isoforms
T12204 517-521 NCBITaxon:10088 denotes mice
T12203 499-503 SO:0000704 denotes Gene
T12202 447-456 GO:0065007 denotes regulated
T12201 413-421 SO:0001060 denotes isoforms
T12200 204-214 CHEBI:35222 denotes inhibitors

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12453 1664-1673 UBERON:0000922 denotes embryonic
T12452 1620-1627 SO_EXT:0001060 denotes isoform
T12451 1590-1603 GO:0009790 denotes embryogenesis
T12450 1547-1556 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12449 1406-1426 GO:0070527 denotes platelet aggregation
T12448 1406-1414 CL:0000233 denotes platelet
T12447 1352-1361 GO_MOP_EXT:catalysis denotes catalytic
T12446 1342-1369 PR_EXT:000005009 denotes μ-calpain catalytic subunit
T12445 1342-1351 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T12444 1321-1325 NCBITaxon:10088 denotes mice
T12443 1319-1320 SO_EXT:sequence_nullness_or_absence denotes -
T12442 1317-1318 SO_EXT:sequence_nullness_or_absence denotes -
T12441 1312-1317 PR_EXT:000005009 denotes Capn1
T12440 1222-1229 SO_EXT:0001060 denotes isoform
T12439 1176-1185 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12438 1178-1185 GO_PR_EXT:calpain_1_complex denotes calpain
T12437 1169-1171 _FRAGMENT denotes μ-
T12436 1139-1148 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12435 1112-1121 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T12434 1085-1093 SO_EXT:0001060 denotes isoforms
T12433 1054-1075 GO:0009790 denotes embryonic development
T12432 1054-1063 UBERON:0000922 denotes embryonic
T12431 966-975 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12430 968-975 GO_PR_EXT:calpain_1_complex denotes calpain
T12429 959-961 _FRAGMENT denotes μ-
T12428 814-818 NCBITaxon:10088 denotes mice
T12427 799-804 PR_EXT:000005022 denotes Capn4
T12426 786-795 GO_EXT:fatality_or_lethality denotes lethality
T12425 776-785 UBERON:0000922 denotes embryonic
T12424 727-736 GO_PR_EXT:calpain_2_complex denotes m-calpain
T12423 729-736 GO_PR_EXT:calpain_1_complex denotes calpain
T12422 720-722 _FRAGMENT denotes μ-
T12421 686-696 GO:0065007 denotes regulatory
T12420 667-675 SO_EXT:sequence_coding_function denotes encoding
T12419 661-665 SO_EXT:0000704 denotes gene
T12418 655-660 PR_EXT:000005022 denotes Capn4
T12417 610-618 SO_EXT:0001060 denotes isoforms
T12416 570-581 GO_PATO_EXT:physiological_process_or_quality denotes physiologic
T12415 517-521 NCBITaxon:10088 denotes mice
T12414 499-503 SO_EXT:0000704 denotes Gene
T12413 447-456 GO:0065007 denotes regulated
T12412 413-421 SO_EXT:0001060 denotes isoforms
T12411 292-301 GO_EXT:0008233 denotes proteases
T12410 239-254 GO_EXT:negative_regulation denotes down-regulating
T12409 204-214 CHEBI_EXT:35222 denotes inhibitors
T12408 126-133 CHEBI_GO_SO_EXT:enzyme denotes enzymes
R2358 T12423 T12422 _lexicallyChainedTo calpain,μ-
R2361 T12430 T12429 _lexicallyChainedTo calpain,μ-
R2362 T12438 T12437 _lexicallyChainedTo calpain,μ-