Id |
Subject |
Object |
Predicate |
Lexical cue |
T3244 |
11-14 |
DT |
denotes |
The |
T3245 |
55-64 |
NNS |
denotes |
proteases |
T3246 |
15-18 |
CD |
denotes |
two |
T3247 |
19-29 |
JJ |
denotes |
ubiquitous |
T3248 |
30-33 |
NN |
denotes |
Ca2 |
T3249 |
35-44 |
JJ |
denotes |
dependent |
T3250 |
33-34 |
SYM |
denotes |
+ |
T3251 |
34-35 |
HYPH |
denotes |
- |
T3252 |
44-46 |
, |
denotes |
, |
T3253 |
46-54 |
NN |
denotes |
cysteine |
T3254 |
122-125 |
VBP |
denotes |
are |
T3255 |
65-70 |
VBN |
denotes |
known |
T3256 |
71-73 |
IN |
denotes |
as |
T3257 |
74-75 |
NN |
denotes |
μ |
T3258 |
76-83 |
NN |
denotes |
calpain |
T3259 |
75-76 |
HYPH |
denotes |
- |
T3260 |
84-85 |
-LRB- |
denotes |
( |
T3261 |
85-92 |
NN |
denotes |
calpain |
T3262 |
92-93 |
HYPH |
denotes |
- |
T3263 |
93-94 |
CD |
denotes |
1 |
T3264 |
94-95 |
-RRB- |
denotes |
) |
T3265 |
96-99 |
CC |
denotes |
and |
T3266 |
100-101 |
NN |
denotes |
m |
T3267 |
102-109 |
NN |
denotes |
calpain |
T3268 |
101-102 |
HYPH |
denotes |
- |
T3269 |
110-111 |
-LRB- |
denotes |
( |
T3270 |
111-117 |
NN |
denotes |
capain |
T3271 |
117-118 |
HYPH |
denotes |
- |
T3272 |
118-119 |
CD |
denotes |
2 |
T3273 |
119-120 |
-RRB- |
denotes |
) |
T3274 |
120-122 |
, |
denotes |
, |
T3275 |
126-129 |
DT |
denotes |
the |
T3276 |
139-146 |
NNS |
denotes |
members |
T3277 |
130-138 |
NN |
denotes |
founding |
T3278 |
147-149 |
IN |
denotes |
of |
T3279 |
150-151 |
DT |
denotes |
a |
T3280 |
157-163 |
NN |
denotes |
family |
T3281 |
152-156 |
NN |
denotes |
gene |
T3282 |
164-174 |
VBG |
denotes |
comprising |
T3283 |
175-177 |
CD |
denotes |
13 |
T3284 |
178-183 |
NNS |
denotes |
genes |
T3285 |
184-186 |
IN |
denotes |
in |
T3286 |
187-194 |
NNS |
denotes |
mammals |
T3287 |
195-196 |
-LRB- |
denotes |
[ |
T3288 |
196-197 |
CD |
denotes |
1 |
T3289 |
197-198 |
SYM |
denotes |
- |
T3290 |
198-199 |
CD |
denotes |
3 |
T3291 |
199-200 |
-RRB- |
denotes |
] |
T3292 |
200-201 |
. |
denotes |
. |
T3293 |
201-434 |
sentence |
denotes |
Both are heterodimeric enzymes consisting of distinct 80 kDa catalytic subunits, encoded by the Capn1 (μ-80 k) and Capn2 (m-80 k) genes, respectively, that associate with a common 28 kDa regulatory subunit encoded by the Capn4 gene. |
T3294 |
202-206 |
DT |
denotes |
Both |
T3295 |
207-210 |
VBP |
denotes |
are |
T3296 |
211-224 |
JJ |
denotes |
heterodimeric |
T3297 |
225-232 |
NNS |
denotes |
enzymes |
T3298 |
233-243 |
VBG |
denotes |
consisting |
T3299 |
244-246 |
IN |
denotes |
of |
T3300 |
247-255 |
JJ |
denotes |
distinct |
T3301 |
273-281 |
NNS |
denotes |
subunits |
T3302 |
256-258 |
CD |
denotes |
80 |
T3303 |
259-262 |
NN |
denotes |
kDa |
T3304 |
263-272 |
JJ |
denotes |
catalytic |
T3305 |
281-283 |
, |
denotes |
, |
T3306 |
283-290 |
VBN |
denotes |
encoded |
T3307 |
291-293 |
IN |
denotes |
by |
T3308 |
294-297 |
DT |
denotes |
the |
T3309 |
332-337 |
NNS |
denotes |
genes |
T3310 |
298-303 |
NN |
denotes |
Capn1 |
T3311 |
304-305 |
-LRB- |
denotes |
( |
T3312 |
310-311 |
NN |
denotes |
k |
T3313 |
305-306 |
NN |
denotes |
μ |
T3314 |
306-307 |
HYPH |
denotes |
- |
T3315 |
307-309 |
CD |
denotes |
80 |
T3316 |
311-312 |
-RRB- |
denotes |
) |
T3317 |
313-316 |
CC |
denotes |
and |
T3318 |
317-322 |
NN |
denotes |
Capn2 |
T3319 |
323-324 |
-LRB- |
denotes |
( |
T3320 |
329-330 |
NN |
denotes |
k |
T3321 |
324-325 |
NN |
denotes |
m |
T3322 |
325-326 |
HYPH |
denotes |
- |
T3323 |
326-328 |
CD |
denotes |
80 |
T3324 |
330-331 |
-RRB- |
denotes |
) |
T3325 |
337-339 |
, |
denotes |
, |
T3326 |
339-351 |
RB |
denotes |
respectively |
T3327 |
351-353 |
, |
denotes |
, |
T3328 |
353-357 |
WDT |
denotes |
that |
T3329 |
358-367 |
VBP |
denotes |
associate |
T3330 |
368-372 |
IN |
denotes |
with |
T3331 |
373-374 |
DT |
denotes |
a |
T3332 |
400-407 |
NN |
denotes |
subunit |
T3333 |
375-381 |
JJ |
denotes |
common |
T3334 |
382-384 |
CD |
denotes |
28 |
T3335 |
385-388 |
NN |
denotes |
kDa |
T3336 |
389-399 |
JJ |
denotes |
regulatory |
T3337 |
408-415 |
VBN |
denotes |
encoded |
T3338 |
416-418 |
IN |
denotes |
by |
T3339 |
419-422 |
DT |
denotes |
the |
T3340 |
429-433 |
NN |
denotes |
gene |
T3341 |
423-428 |
NN |
denotes |
Capn4 |
T3342 |
433-434 |
. |
denotes |
. |
T3343 |
434-604 |
sentence |
denotes |
The μ-80 k and m-80 k subunits share 62% amino acid sequence identity, and are very similar in terms of structure, protein chemistry, and in vitro substrate specificity. |
T3344 |
435-438 |
DT |
denotes |
The |
T3345 |
457-465 |
NNS |
denotes |
subunits |
T3346 |
439-440 |
NN |
denotes |
μ |
T3347 |
444-445 |
NN |
denotes |
k |
T3348 |
440-441 |
HYPH |
denotes |
- |
T3349 |
441-443 |
CD |
denotes |
80 |
T3350 |
446-449 |
CC |
denotes |
and |
T3351 |
450-451 |
NN |
denotes |
m |
T3352 |
455-456 |
NN |
denotes |
k |
T3353 |
451-452 |
HYPH |
denotes |
- |
T3354 |
452-454 |
CD |
denotes |
80 |
T3355 |
466-471 |
VBP |
denotes |
share |
T3356 |
472-474 |
CD |
denotes |
62 |
T3357 |
474-475 |
NN |
denotes |
% |
T3358 |
496-504 |
NN |
denotes |
identity |
T3359 |
476-481 |
NN |
denotes |
amino |
T3360 |
482-486 |
NN |
denotes |
acid |
T3361 |
487-495 |
NN |
denotes |
sequence |
T3362 |
504-506 |
, |
denotes |
, |
T3363 |
506-509 |
CC |
denotes |
and |
T3364 |
510-513 |
VBP |
denotes |
are |
T3365 |
514-518 |
RB |
denotes |
very |
T3366 |
519-526 |
JJ |
denotes |
similar |
T3367 |
527-529 |
IN |
denotes |
in |
T3368 |
530-535 |
NNS |
denotes |
terms |
T3369 |
536-538 |
IN |
denotes |
of |
T3370 |
539-548 |
NN |
denotes |
structure |
T3371 |
548-550 |
, |
denotes |
, |
T3372 |
550-557 |
NN |
denotes |
protein |
T3373 |
558-567 |
NN |
denotes |
chemistry |
T3374 |
567-569 |
, |
denotes |
, |
T3375 |
569-572 |
CC |
denotes |
and |
T3376 |
573-575 |
FW |
denotes |
in |
T3377 |
576-581 |
FW |
denotes |
vitro |
T3378 |
592-603 |
NN |
denotes |
specificity |
T3379 |
582-591 |
NN |
denotes |
substrate |
T3380 |
603-604 |
. |
denotes |
. |
T3381 |
604-774 |
sentence |
denotes |
Despite these similarities, the differential expression patterns of μ- and m-calpain in mammalian tissues suggest they have some isoform specific and distinct functions. |
T3382 |
605-612 |
IN |
denotes |
Despite |
T3383 |
711-718 |
VBP |
denotes |
suggest |
T3384 |
613-618 |
DT |
denotes |
these |
T3385 |
619-631 |
NNS |
denotes |
similarities |
T3386 |
631-633 |
, |
denotes |
, |
T3387 |
633-636 |
DT |
denotes |
the |
T3388 |
661-669 |
NNS |
denotes |
patterns |
T3389 |
637-649 |
JJ |
denotes |
differential |
T3390 |
650-660 |
NN |
denotes |
expression |
T3391 |
670-672 |
IN |
denotes |
of |
T3392 |
673-674 |
NN |
denotes |
μ |
T3393 |
682-689 |
NN |
denotes |
calpain |
T3394 |
674-675 |
HYPH |
denotes |
- |
T3395 |
676-679 |
CC |
denotes |
and |
T3396 |
680-681 |
NN |
denotes |
m |
T3397 |
681-682 |
HYPH |
denotes |
- |
T3398 |
690-692 |
IN |
denotes |
in |
T3399 |
693-702 |
JJ |
denotes |
mammalian |
T3400 |
703-710 |
NNS |
denotes |
tissues |
T3401 |
719-723 |
PRP |
denotes |
they |
T3402 |
724-728 |
VBP |
denotes |
have |
T3403 |
729-733 |
DT |
denotes |
some |
T3404 |
764-773 |
NNS |
denotes |
functions |
T3405 |
734-741 |
NN |
denotes |
isoform |
T3406 |
742-750 |
JJ |
denotes |
specific |
T3407 |
751-754 |
CC |
denotes |
and |
T3408 |
755-763 |
JJ |
denotes |
distinct |
T3409 |
773-774 |
. |
denotes |
. |
T3410 |
774-936 |
sentence |
denotes |
The μ and m designations derive from the levels of Ca2+ required in vitro for optimal activation; 10–50 μM Ca2+ for μ-calpain and 0.3–0.35 mM Ca2+ for m-calpain. |
T3411 |
775-778 |
DT |
denotes |
The |
T3412 |
787-799 |
NNS |
denotes |
designations |
T3413 |
779-780 |
NN |
denotes |
μ |
T3414 |
781-784 |
CC |
denotes |
and |
T3415 |
785-786 |
NN |
denotes |
m |
T3416 |
800-806 |
VBP |
denotes |
derive |
T3417 |
807-811 |
IN |
denotes |
from |
T3418 |
812-815 |
DT |
denotes |
the |
T3419 |
816-822 |
NNS |
denotes |
levels |
T3420 |
823-825 |
IN |
denotes |
of |
T3421 |
826-829 |
NN |
denotes |
Ca2 |
T3422 |
829-830 |
SYM |
denotes |
+ |
T3423 |
831-839 |
VBN |
denotes |
required |
T3424 |
840-842 |
FW |
denotes |
in |
T3425 |
843-848 |
FW |
denotes |
vitro |
T3426 |
849-852 |
IN |
denotes |
for |
T3427 |
853-860 |
JJ |
denotes |
optimal |
T3428 |
861-871 |
NN |
denotes |
activation |
T3429 |
871-872 |
: |
denotes |
; |
T3430 |
873-875 |
CD |
denotes |
10 |
T3431 |
876-878 |
CD |
denotes |
50 |
T3432 |
875-876 |
SYM |
denotes |
– |
T3433 |
879-881 |
NN |
denotes |
μM |
T3434 |
882-885 |
NN |
denotes |
Ca2 |
T3435 |
885-886 |
SYM |
denotes |
+ |
T3436 |
887-890 |
IN |
denotes |
for |
T3437 |
891-892 |
NN |
denotes |
μ |
T3438 |
893-900 |
NN |
denotes |
calpain |
T3439 |
892-893 |
HYPH |
denotes |
- |
T3440 |
901-904 |
CC |
denotes |
and |
T3441 |
905-908 |
CD |
denotes |
0.3 |
T3442 |
909-913 |
CD |
denotes |
0.35 |
T3443 |
908-909 |
SYM |
denotes |
– |
T3444 |
914-916 |
NN |
denotes |
mM |
T3445 |
917-920 |
NN |
denotes |
Ca2 |
T3446 |
920-921 |
SYM |
denotes |
+ |
T3447 |
922-925 |
IN |
denotes |
for |
T3448 |
926-927 |
NN |
denotes |
m |
T3449 |
928-935 |
NN |
denotes |
calpain |
T3450 |
927-928 |
HYPH |
denotes |
- |
T3451 |
935-936 |
. |
denotes |
. |
T3452 |
936-1098 |
sentence |
denotes |
It is generally assumed that μ- and m-calpain maintain their differential sensitivities to calcium in vivo, although this has not yet been strictly demonstrated. |
T3453 |
937-939 |
PRP |
denotes |
It |
T3454 |
953-960 |
VBN |
denotes |
assumed |
T3455 |
940-942 |
VBZ |
denotes |
is |
T3456 |
943-952 |
RB |
denotes |
generally |
T3457 |
961-965 |
IN |
denotes |
that |
T3458 |
983-991 |
VBP |
denotes |
maintain |
T3459 |
966-967 |
NN |
denotes |
μ |
T3460 |
975-982 |
NN |
denotes |
calpain |
T3461 |
967-968 |
HYPH |
denotes |
- |
T3462 |
969-972 |
CC |
denotes |
and |
T3463 |
973-974 |
NN |
denotes |
m |
T3464 |
974-975 |
HYPH |
denotes |
- |
T3465 |
992-997 |
PRP$ |
denotes |
their |
T3466 |
1011-1024 |
NNS |
denotes |
sensitivities |
T3467 |
998-1010 |
JJ |
denotes |
differential |
T3468 |
1025-1027 |
IN |
denotes |
to |
T3469 |
1028-1035 |
NN |
denotes |
calcium |
T3470 |
1036-1038 |
FW |
denotes |
in |
T3471 |
1039-1043 |
FW |
denotes |
vivo |
T3472 |
1043-1045 |
, |
denotes |
, |
T3473 |
1045-1053 |
IN |
denotes |
although |
T3474 |
1085-1097 |
VBN |
denotes |
demonstrated |
T3475 |
1054-1058 |
DT |
denotes |
this |
T3476 |
1059-1062 |
VBZ |
denotes |
has |
T3477 |
1063-1066 |
RB |
denotes |
not |
T3478 |
1067-1070 |
RB |
denotes |
yet |
T3479 |
1071-1075 |
VBN |
denotes |
been |
T3480 |
1076-1084 |
RB |
denotes |
strictly |
T3481 |
1097-1098 |
. |
denotes |
. |
T3482 |
1098-1284 |
sentence |
denotes |
Furthermore, since the cytoplasmic free Ca2+ concentration is typically less than 1 μM, it is also assumed that other in vivo factors must contribute to regulation of these enzymes [3]. |
T3483 |
1099-1110 |
RB |
denotes |
Furthermore |
T3484 |
1198-1205 |
VBN |
denotes |
assumed |
T3485 |
1110-1112 |
, |
denotes |
, |
T3486 |
1112-1117 |
IN |
denotes |
since |
T3487 |
1158-1160 |
VBZ |
denotes |
is |
T3488 |
1118-1121 |
DT |
denotes |
the |
T3489 |
1144-1157 |
NN |
denotes |
concentration |
T3490 |
1122-1133 |
JJ |
denotes |
cytoplasmic |
T3491 |
1134-1138 |
JJ |
denotes |
free |
T3492 |
1139-1142 |
NN |
denotes |
Ca2 |
T3493 |
1142-1143 |
SYM |
denotes |
+ |
T3494 |
1161-1170 |
RB |
denotes |
typically |
T3495 |
1171-1175 |
JJR |
denotes |
less |
T3496 |
1181-1182 |
CD |
denotes |
1 |
T3497 |
1176-1180 |
IN |
denotes |
than |
T3498 |
1183-1185 |
NN |
denotes |
μM |
T3499 |
1185-1187 |
, |
denotes |
, |
T3500 |
1187-1189 |
PRP |
denotes |
it |
T3501 |
1190-1192 |
VBZ |
denotes |
is |
T3502 |
1193-1197 |
RB |
denotes |
also |
T3503 |
1206-1210 |
IN |
denotes |
that |
T3504 |
1238-1248 |
VB |
denotes |
contribute |
T3505 |
1211-1216 |
JJ |
denotes |
other |
T3506 |
1225-1232 |
NNS |
denotes |
factors |
T3507 |
1217-1219 |
FW |
denotes |
in |
T3508 |
1220-1224 |
FW |
denotes |
vivo |
T3509 |
1233-1237 |
MD |
denotes |
must |
T3510 |
1249-1251 |
IN |
denotes |
to |
T3511 |
1252-1262 |
NN |
denotes |
regulation |
T3512 |
1263-1265 |
IN |
denotes |
of |
T3513 |
1266-1271 |
DT |
denotes |
these |
T3514 |
1272-1279 |
NNS |
denotes |
enzymes |
T3515 |
1280-1281 |
-LRB- |
denotes |
[ |
T3516 |
1281-1282 |
CD |
denotes |
3 |
T3517 |
1282-1283 |
-RRB- |
denotes |
] |
T3518 |
1283-1284 |
. |
denotes |
. |
T3519 |
1284-1454 |
sentence |
denotes |
Without apriori knowledge of the factors regulating calpain activity or their relevant substrates, elucidation of biological functions for calpains presents a challenge. |
T3520 |
1285-1292 |
IN |
denotes |
Without |
T3521 |
1433-1441 |
VBZ |
denotes |
presents |
T3522 |
1293-1300 |
FW |
denotes |
apriori |
T3523 |
1301-1310 |
NN |
denotes |
knowledge |
T3524 |
1311-1313 |
IN |
denotes |
of |
T3525 |
1314-1317 |
DT |
denotes |
the |
T3526 |
1318-1325 |
NNS |
denotes |
factors |
T3527 |
1326-1336 |
VBG |
denotes |
regulating |
T3528 |
1337-1344 |
NN |
denotes |
calpain |
T3529 |
1345-1353 |
NN |
denotes |
activity |
T3530 |
1354-1356 |
CC |
denotes |
or |
T3531 |
1357-1362 |
PRP$ |
denotes |
their |
T3532 |
1372-1382 |
NNS |
denotes |
substrates |
T3533 |
1363-1371 |
JJ |
denotes |
relevant |
T3534 |
1382-1384 |
, |
denotes |
, |
T3535 |
1384-1395 |
NN |
denotes |
elucidation |
T3536 |
1396-1398 |
IN |
denotes |
of |
T3537 |
1399-1409 |
JJ |
denotes |
biological |
T3538 |
1410-1419 |
NNS |
denotes |
functions |
T3539 |
1420-1423 |
IN |
denotes |
for |
T3540 |
1424-1432 |
NNS |
denotes |
calpains |
T3541 |
1442-1443 |
DT |
denotes |
a |
T3542 |
1444-1453 |
NN |
denotes |
challenge |
T3543 |
1453-1454 |
. |
denotes |
. |
T3544 |
1454-1869 |
sentence |
denotes |
Research on calpains has linked them with a wide variety of functions including muscle growth, development, degeneration (3), neuronal growth and neurodegeneration [4], cell cycle progression [5,6], signal cascades triggered by integrins and growth factors [7], membrane protrusion [8], remodeling of the cytoskeleton and cell migration [9-15], and regulation of cell death via both necrosis and apoptosis [16-22]. |
T3545 |
1455-1463 |
NN |
denotes |
Research |
T3546 |
1480-1486 |
VBN |
denotes |
linked |
T3547 |
1464-1466 |
IN |
denotes |
on |
T3548 |
1467-1475 |
NNS |
denotes |
calpains |
T3549 |
1476-1479 |
VBZ |
denotes |
has |
T3550 |
1487-1491 |
PRP |
denotes |
them |
T3551 |
1492-1496 |
IN |
denotes |
with |
T3552 |
1497-1498 |
DT |
denotes |
a |
T3553 |
1504-1511 |
NN |
denotes |
variety |
T3554 |
1499-1503 |
JJ |
denotes |
wide |
T3555 |
1512-1514 |
IN |
denotes |
of |
T3556 |
1515-1524 |
NNS |
denotes |
functions |
T3557 |
1525-1534 |
VBG |
denotes |
including |
T3558 |
1535-1541 |
NN |
denotes |
muscle |
T3559 |
1542-1548 |
NN |
denotes |
growth |
T3560 |
1548-1550 |
, |
denotes |
, |
T3561 |
1550-1561 |
NN |
denotes |
development |
T3562 |
1561-1563 |
, |
denotes |
, |
T3563 |
1563-1575 |
NN |
denotes |
degeneration |
T3564 |
1576-1577 |
-LRB- |
denotes |
( |
T3565 |
1577-1578 |
CD |
denotes |
3 |
T3566 |
1578-1579 |
-RRB- |
denotes |
) |
T3567 |
1579-1581 |
, |
denotes |
, |
T3568 |
1581-1589 |
JJ |
denotes |
neuronal |
T3569 |
1590-1596 |
NN |
denotes |
growth |
T3570 |
1597-1600 |
CC |
denotes |
and |
T3571 |
1601-1618 |
NN |
denotes |
neurodegeneration |
T3572 |
1619-1620 |
-LRB- |
denotes |
[ |
T3573 |
1620-1621 |
CD |
denotes |
4 |
T3574 |
1621-1622 |
-RRB- |
denotes |
] |
T3575 |
1622-1624 |
, |
denotes |
, |
T3576 |
1624-1628 |
NN |
denotes |
cell |
T3577 |
1629-1634 |
NN |
denotes |
cycle |
T3578 |
1635-1646 |
NN |
denotes |
progression |
T3579 |
1647-1648 |
-LRB- |
denotes |
[ |
T3580 |
1650-1651 |
CD |
denotes |
6 |
T3581 |
1648-1649 |
CD |
denotes |
5 |
T3582 |
1649-1650 |
, |
denotes |
, |
T3583 |
1651-1652 |
-RRB- |
denotes |
] |
T3584 |
1652-1654 |
, |
denotes |
, |
T3585 |
1654-1660 |
NN |
denotes |
signal |
T3586 |
1661-1669 |
NNS |
denotes |
cascades |
T3587 |
1670-1679 |
VBN |
denotes |
triggered |
T3588 |
1680-1682 |
IN |
denotes |
by |
T3589 |
1683-1692 |
NNS |
denotes |
integrins |
T3590 |
1693-1696 |
CC |
denotes |
and |
T3591 |
1697-1703 |
NN |
denotes |
growth |
T3592 |
1704-1711 |
NNS |
denotes |
factors |
T3593 |
1712-1713 |
-LRB- |
denotes |
[ |
T3594 |
1713-1714 |
CD |
denotes |
7 |
T3595 |
1714-1715 |
-RRB- |
denotes |
] |
T3596 |
1715-1717 |
, |
denotes |
, |
T3597 |
1717-1725 |
NN |
denotes |
membrane |
T3598 |
1726-1736 |
NN |
denotes |
protrusion |
T3599 |
1737-1738 |
-LRB- |
denotes |
[ |
T3600 |
1738-1739 |
CD |
denotes |
8 |
T3601 |
1739-1740 |
-RRB- |
denotes |
] |
T3602 |
1740-1742 |
, |
denotes |
, |
T3603 |
1742-1752 |
VBG |
denotes |
remodeling |
T3604 |
1753-1755 |
IN |
denotes |
of |
T3605 |
1756-1759 |
DT |
denotes |
the |
T3606 |
1760-1772 |
NN |
denotes |
cytoskeleton |
T3607 |
1773-1776 |
CC |
denotes |
and |
T3608 |
1777-1781 |
NN |
denotes |
cell |
T3609 |
1782-1791 |
NN |
denotes |
migration |
T3610 |
1792-1793 |
-LRB- |
denotes |
[ |
T3611 |
1793-1794 |
CD |
denotes |
9 |
T3612 |
1794-1795 |
SYM |
denotes |
- |
T3613 |
1795-1797 |
CD |
denotes |
15 |
T3614 |
1797-1798 |
-RRB- |
denotes |
] |
T3615 |
1798-1800 |
, |
denotes |
, |
T3616 |
1800-1803 |
CC |
denotes |
and |
T3617 |
1804-1814 |
NN |
denotes |
regulation |
T3618 |
1815-1817 |
IN |
denotes |
of |
T3619 |
1818-1822 |
NN |
denotes |
cell |
T3620 |
1823-1828 |
NN |
denotes |
death |
T3621 |
1829-1832 |
IN |
denotes |
via |
T3622 |
1833-1837 |
CC |
denotes |
both |
T3623 |
1838-1846 |
NN |
denotes |
necrosis |
T3624 |
1847-1850 |
CC |
denotes |
and |
T3625 |
1851-1860 |
NN |
denotes |
apoptosis |
T3626 |
1861-1862 |
-LRB- |
denotes |
[ |
T3627 |
1862-1864 |
CD |
denotes |
16 |
T3628 |
1864-1865 |
SYM |
denotes |
- |
T3629 |
1865-1867 |
CD |
denotes |
22 |
T3630 |
1867-1868 |
-RRB- |
denotes |
] |
T3631 |
1868-1869 |
. |
denotes |
. |
T3632 |
1869-2021 |
sentence |
denotes |
To date, the literature suggests a complex interplay between caspases and calpains [23,24] and impact of calpain on cell death pathway components [25]. |
T3633 |
1870-1872 |
IN |
denotes |
To |
T3634 |
1894-1902 |
VBZ |
denotes |
suggests |
T3635 |
1873-1877 |
NN |
denotes |
date |
T3636 |
1877-1879 |
, |
denotes |
, |
T3637 |
1879-1882 |
DT |
denotes |
the |
T3638 |
1883-1893 |
NN |
denotes |
literature |
T3639 |
1903-1904 |
DT |
denotes |
a |
T3640 |
1913-1922 |
NN |
denotes |
interplay |
T3641 |
1905-1912 |
JJ |
denotes |
complex |
T3642 |
1923-1930 |
IN |
denotes |
between |
T3643 |
1931-1939 |
NNS |
denotes |
caspases |
T3644 |
1940-1943 |
CC |
denotes |
and |
T3645 |
1944-1952 |
NNS |
denotes |
calpains |
T3646 |
1953-1954 |
-LRB- |
denotes |
[ |
T3647 |
1957-1959 |
CD |
denotes |
24 |
T3648 |
1954-1956 |
CD |
denotes |
23 |
T3649 |
1956-1957 |
, |
denotes |
, |
T3650 |
1959-1960 |
-RRB- |
denotes |
] |
T3651 |
1961-1964 |
CC |
denotes |
and |
T3652 |
1965-1971 |
NN |
denotes |
impact |
T3653 |
1972-1974 |
IN |
denotes |
of |
T3654 |
1975-1982 |
NN |
denotes |
calpain |
T3655 |
1983-1985 |
IN |
denotes |
on |
T3656 |
1986-1990 |
NN |
denotes |
cell |
T3657 |
1991-1996 |
NN |
denotes |
death |
T3658 |
2005-2015 |
NNS |
denotes |
components |
T3659 |
1997-2004 |
NN |
denotes |
pathway |
T3660 |
2016-2017 |
-LRB- |
denotes |
[ |
T3661 |
2017-2019 |
CD |
denotes |
25 |
T3662 |
2019-2020 |
-RRB- |
denotes |
] |
T3663 |
2020-2021 |
. |
denotes |
. |
T3664 |
2021-2184 |
sentence |
denotes |
The lack of highly specific cell-permeable inhibitors of calpains contributes to the challenge of investigating and defining calpain functions in these processes. |
T3665 |
2022-2025 |
DT |
denotes |
The |
T3666 |
2026-2030 |
NN |
denotes |
lack |
T3667 |
2088-2099 |
VBZ |
denotes |
contributes |
T3668 |
2031-2033 |
IN |
denotes |
of |
T3669 |
2034-2040 |
RB |
denotes |
highly |
T3670 |
2041-2049 |
JJ |
denotes |
specific |
T3671 |
2065-2075 |
NNS |
denotes |
inhibitors |
T3672 |
2050-2054 |
NN |
denotes |
cell |
T3673 |
2055-2064 |
JJ |
denotes |
permeable |
T3674 |
2054-2055 |
HYPH |
denotes |
- |
T3675 |
2076-2078 |
IN |
denotes |
of |
T3676 |
2079-2087 |
NNS |
denotes |
calpains |
T3677 |
2100-2102 |
IN |
denotes |
to |
T3678 |
2103-2106 |
DT |
denotes |
the |
T3679 |
2107-2116 |
NN |
denotes |
challenge |
T3680 |
2117-2119 |
IN |
denotes |
of |
T3681 |
2120-2133 |
VBG |
denotes |
investigating |
T3682 |
2134-2137 |
CC |
denotes |
and |
T3683 |
2138-2146 |
VBG |
denotes |
defining |
T3684 |
2147-2154 |
NN |
denotes |
calpain |
T3685 |
2155-2164 |
NNS |
denotes |
functions |
T3686 |
2165-2167 |
IN |
denotes |
in |
T3687 |
2168-2173 |
DT |
denotes |
these |
T3688 |
2174-2183 |
NNS |
denotes |
processes |
T3689 |
2183-2184 |
. |
denotes |
. |
T3690 |
2184-2391 |
sentence |
denotes |
Although over-expression of calpastatin, the endogenous protein inhibitor of μ- and m-calpain provides an important approach for these efforts, it will not distinguish isoform specific functions [24,26,27]. |
T3691 |
2185-2193 |
IN |
denotes |
Although |
T3692 |
2279-2287 |
VBZ |
denotes |
provides |
T3693 |
2194-2209 |
NN |
denotes |
over-expression |
T3694 |
2210-2212 |
IN |
denotes |
of |
T3695 |
2213-2224 |
NN |
denotes |
calpastatin |
T3696 |
2224-2226 |
, |
denotes |
, |
T3697 |
2226-2229 |
DT |
denotes |
the |
T3698 |
2249-2258 |
NN |
denotes |
inhibitor |
T3699 |
2230-2240 |
JJ |
denotes |
endogenous |
T3700 |
2241-2248 |
NN |
denotes |
protein |
T3701 |
2259-2261 |
IN |
denotes |
of |
T3702 |
2262-2263 |
NN |
denotes |
μ |
T3703 |
2271-2278 |
NN |
denotes |
calpain |
T3704 |
2263-2264 |
HYPH |
denotes |
- |
T3705 |
2265-2268 |
CC |
denotes |
and |
T3706 |
2269-2270 |
NN |
denotes |
m |
T3707 |
2270-2271 |
HYPH |
denotes |
- |
T3708 |
2341-2352 |
VB |
denotes |
distinguish |
T3709 |
2288-2290 |
DT |
denotes |
an |
T3710 |
2301-2309 |
NN |
denotes |
approach |
T3711 |
2291-2300 |
JJ |
denotes |
important |
T3712 |
2310-2313 |
IN |
denotes |
for |
T3713 |
2314-2319 |
DT |
denotes |
these |
T3714 |
2320-2327 |
NNS |
denotes |
efforts |
T3715 |
2327-2329 |
, |
denotes |
, |
T3716 |
2329-2331 |
PRP |
denotes |
it |
T3717 |
2332-2336 |
MD |
denotes |
will |
T3718 |
2337-2340 |
RB |
denotes |
not |
T3719 |
2353-2360 |
NN |
denotes |
isoform |
T3720 |
2361-2369 |
JJ |
denotes |
specific |
T3721 |
2370-2379 |
NNS |
denotes |
functions |
T3722 |
2380-2381 |
-LRB- |
denotes |
[ |
T3723 |
2387-2389 |
CD |
denotes |
27 |
T3724 |
2381-2383 |
CD |
denotes |
24 |
T3725 |
2383-2384 |
, |
denotes |
, |
T3726 |
2384-2386 |
CD |
denotes |
26 |
T3727 |
2386-2387 |
, |
denotes |
, |
T3728 |
2389-2390 |
-RRB- |
denotes |
] |
T3729 |
2390-2391 |
. |
denotes |
. |
T3730 |
2391-2631 |
sentence |
denotes |
Some work has suggested isoform specific roles, such as a role for m-calpain in epidermal growth factor (EGF)-induced cell motility [28,29] and a role for μ-calpain in interferon-inducible protein 9-induced migration of keratinocytes [28]. |
T3731 |
2392-2396 |
DT |
denotes |
Some |
T3732 |
2397-2401 |
NN |
denotes |
work |
T3733 |
2406-2415 |
VBN |
denotes |
suggested |
T3734 |
2402-2405 |
VBZ |
denotes |
has |
T3735 |
2416-2423 |
NN |
denotes |
isoform |
T3736 |
2424-2432 |
JJ |
denotes |
specific |
T3737 |
2433-2438 |
NNS |
denotes |
roles |
T3738 |
2438-2440 |
, |
denotes |
, |
T3739 |
2440-2444 |
JJ |
denotes |
such |
T3740 |
2445-2447 |
IN |
denotes |
as |
T3741 |
2448-2449 |
DT |
denotes |
a |
T3742 |
2450-2454 |
NN |
denotes |
role |
T3743 |
2455-2458 |
IN |
denotes |
for |
T3744 |
2459-2460 |
NN |
denotes |
m |
T3745 |
2461-2468 |
NN |
denotes |
calpain |
T3746 |
2460-2461 |
HYPH |
denotes |
- |
T3747 |
2469-2471 |
IN |
denotes |
in |
T3748 |
2472-2481 |
JJ |
denotes |
epidermal |
T3749 |
2489-2495 |
NN |
denotes |
factor |
T3750 |
2482-2488 |
NN |
denotes |
growth |
T3751 |
2502-2509 |
VBN |
denotes |
induced |
T3752 |
2496-2497 |
-LRB- |
denotes |
( |
T3753 |
2497-2500 |
NN |
denotes |
EGF |
T3754 |
2500-2501 |
-RRB- |
denotes |
) |
T3755 |
2501-2502 |
HYPH |
denotes |
- |
T3756 |
2515-2523 |
NN |
denotes |
motility |
T3757 |
2510-2514 |
NN |
denotes |
cell |
T3758 |
2524-2525 |
-LRB- |
denotes |
[ |
T3759 |
2528-2530 |
CD |
denotes |
29 |
T3760 |
2525-2527 |
CD |
denotes |
28 |
T3761 |
2527-2528 |
, |
denotes |
, |
T3762 |
2530-2531 |
-RRB- |
denotes |
] |
T3763 |
2532-2535 |
CC |
denotes |
and |
T3764 |
2536-2537 |
DT |
denotes |
a |
T3765 |
2538-2542 |
NN |
denotes |
role |
T3766 |
2543-2546 |
IN |
denotes |
for |
T3767 |
2547-2548 |
NN |
denotes |
μ |
T3768 |
2549-2556 |
NN |
denotes |
calpain |
T3769 |
2548-2549 |
HYPH |
denotes |
- |
T3770 |
2557-2559 |
IN |
denotes |
in |
T3771 |
2560-2570 |
NN |
denotes |
interferon |
T3772 |
2571-2580 |
JJ |
denotes |
inducible |
T3773 |
2570-2571 |
HYPH |
denotes |
- |
T3774 |
2599-2608 |
NN |
denotes |
migration |
T3775 |
2581-2588 |
NN |
denotes |
protein |
T3776 |
2591-2598 |
VBN |
denotes |
induced |
T3777 |
2589-2590 |
CD |
denotes |
9 |
T3778 |
2590-2591 |
HYPH |
denotes |
- |
T3779 |
2609-2611 |
IN |
denotes |
of |
T3780 |
2612-2625 |
NNS |
denotes |
keratinocytes |
T3781 |
2626-2627 |
-LRB- |
denotes |
[ |
T3782 |
2627-2629 |
CD |
denotes |
28 |
T3783 |
2629-2630 |
-RRB- |
denotes |
] |
T3784 |
2630-2631 |
. |
denotes |
. |
T3785 |
2631-2816 |
sentence |
denotes |
A cell permeable calpain inhibitor (which likely inhibits other thiol-proteases as well) has been used to select cells lacking μ-calpain which display reduced proliferation rates [30]. |
T3786 |
2632-2633 |
DT |
denotes |
A |
T3787 |
2657-2666 |
NN |
denotes |
inhibitor |
T3788 |
2634-2638 |
NN |
denotes |
cell |
T3789 |
2639-2648 |
JJ |
denotes |
permeable |
T3790 |
2649-2656 |
NN |
denotes |
calpain |
T3791 |
2730-2734 |
VBN |
denotes |
used |
T3792 |
2667-2668 |
-LRB- |
denotes |
( |
T3793 |
2668-2673 |
WDT |
denotes |
which |
T3794 |
2681-2689 |
VBZ |
denotes |
inhibits |
T3795 |
2674-2680 |
RB |
denotes |
likely |
T3796 |
2690-2695 |
JJ |
denotes |
other |
T3797 |
2702-2711 |
NNS |
denotes |
proteases |
T3798 |
2696-2701 |
NN |
denotes |
thiol |
T3799 |
2701-2702 |
HYPH |
denotes |
- |
T3800 |
2712-2714 |
RB |
denotes |
as |
T3801 |
2715-2719 |
RB |
denotes |
well |
T3802 |
2719-2720 |
-RRB- |
denotes |
) |
T3803 |
2721-2724 |
VBZ |
denotes |
has |
T3804 |
2725-2729 |
VBN |
denotes |
been |
T3805 |
2735-2737 |
TO |
denotes |
to |
T3806 |
2738-2744 |
VB |
denotes |
select |
T3807 |
2745-2750 |
NNS |
denotes |
cells |
T3808 |
2751-2758 |
VBG |
denotes |
lacking |
T3809 |
2759-2760 |
NN |
denotes |
μ |
T3810 |
2761-2768 |
NN |
denotes |
calpain |
T3811 |
2760-2761 |
HYPH |
denotes |
- |
T3812 |
2769-2774 |
WDT |
denotes |
which |
T3813 |
2775-2782 |
VBP |
denotes |
display |
T3814 |
2783-2790 |
VBN |
denotes |
reduced |
T3815 |
2805-2810 |
NNS |
denotes |
rates |
T3816 |
2791-2804 |
NN |
denotes |
proliferation |
T3817 |
2811-2812 |
-LRB- |
denotes |
[ |
T3818 |
2812-2814 |
CD |
denotes |
30 |
T3819 |
2814-2815 |
-RRB- |
denotes |
] |
T3820 |
2815-2816 |
. |
denotes |
. |
T3821 |
2816-2949 |
sentence |
denotes |
Interestingly, m-calpain expression persisted in these cells, suggesting a possible requirement of m-calpain for cell survival [30]. |
T3822 |
2817-2830 |
RB |
denotes |
Interestingly |
T3823 |
2853-2862 |
VBD |
denotes |
persisted |
T3824 |
2830-2832 |
, |
denotes |
, |
T3825 |
2832-2833 |
NN |
denotes |
m |
T3826 |
2834-2841 |
NN |
denotes |
calpain |
T3827 |
2833-2834 |
HYPH |
denotes |
- |
T3828 |
2842-2852 |
NN |
denotes |
expression |
T3829 |
2863-2865 |
IN |
denotes |
in |
T3830 |
2866-2871 |
DT |
denotes |
these |
T3831 |
2872-2877 |
NNS |
denotes |
cells |
T3832 |
2877-2879 |
, |
denotes |
, |
T3833 |
2879-2889 |
VBG |
denotes |
suggesting |
T3834 |
2890-2891 |
DT |
denotes |
a |
T3835 |
2901-2912 |
NN |
denotes |
requirement |
T3836 |
2892-2900 |
JJ |
denotes |
possible |
T3837 |
2913-2915 |
IN |
denotes |
of |
T3838 |
2916-2917 |
NN |
denotes |
m |
T3839 |
2918-2925 |
NN |
denotes |
calpain |
T3840 |
2917-2918 |
HYPH |
denotes |
- |
T3841 |
2926-2929 |
IN |
denotes |
for |
T3842 |
2930-2934 |
NN |
denotes |
cell |
T3843 |
2935-2943 |
NN |
denotes |
survival |
T3844 |
2944-2945 |
-LRB- |
denotes |
[ |
T3845 |
2945-2947 |
CD |
denotes |
30 |
T3846 |
2947-2948 |
-RRB- |
denotes |
] |
T3847 |
2948-2949 |
. |
denotes |
. |
T3848 |
2949-3134 |
sentence |
denotes |
Targeted gene deletion in mice provides a powerful approach to determining the physiological roles of μ- and m-calpain and the opportunity to approach their isoform specific functions. |
T3849 |
2950-2958 |
VBN |
denotes |
Targeted |
T3850 |
2964-2972 |
NN |
denotes |
deletion |
T3851 |
2959-2963 |
NN |
denotes |
gene |
T3852 |
2981-2989 |
VBZ |
denotes |
provides |
T3853 |
2973-2975 |
IN |
denotes |
in |
T3854 |
2976-2980 |
NNS |
denotes |
mice |
T3855 |
2990-2991 |
DT |
denotes |
a |
T3856 |
3001-3009 |
NN |
denotes |
approach |
T3857 |
2992-3000 |
JJ |
denotes |
powerful |
T3858 |
3010-3012 |
IN |
denotes |
to |
T3859 |
3013-3024 |
VBG |
denotes |
determining |
T3860 |
3025-3028 |
DT |
denotes |
the |
T3861 |
3043-3048 |
NNS |
denotes |
roles |
T3862 |
3029-3042 |
JJ |
denotes |
physiological |
T3863 |
3049-3051 |
IN |
denotes |
of |
T3864 |
3052-3053 |
NN |
denotes |
μ |
T3865 |
3061-3068 |
NN |
denotes |
calpain |
T3866 |
3053-3054 |
HYPH |
denotes |
- |
T3867 |
3055-3058 |
CC |
denotes |
and |
T3868 |
3059-3060 |
NN |
denotes |
m |
T3869 |
3060-3061 |
HYPH |
denotes |
- |
T3870 |
3069-3072 |
CC |
denotes |
and |
T3871 |
3073-3076 |
DT |
denotes |
the |
T3872 |
3077-3088 |
NN |
denotes |
opportunity |
T3873 |
3089-3091 |
TO |
denotes |
to |
T3874 |
3092-3100 |
VB |
denotes |
approach |
T3875 |
3101-3106 |
PRP$ |
denotes |
their |
T3876 |
3124-3133 |
NNS |
denotes |
functions |
T3877 |
3107-3114 |
NN |
denotes |
isoform |
T3878 |
3115-3123 |
JJ |
denotes |
specific |
T3879 |
3133-3134 |
. |
denotes |
. |
T3880 |
3134-3272 |
sentence |
denotes |
Initial studies targeted Capn4 based on the prediction that loss of this calpain subunit would abolish activity of both μ- and m-calpain. |
T3881 |
3135-3142 |
JJ |
denotes |
Initial |
T3882 |
3143-3150 |
NNS |
denotes |
studies |
T3883 |
3151-3159 |
VBD |
denotes |
targeted |
T3884 |
3160-3165 |
NN |
denotes |
Capn4 |
T3885 |
3166-3171 |
VBN |
denotes |
based |
T3886 |
3172-3174 |
IN |
denotes |
on |
T3887 |
3175-3178 |
DT |
denotes |
the |
T3888 |
3179-3189 |
NN |
denotes |
prediction |
T3889 |
3190-3194 |
IN |
denotes |
that |
T3890 |
3230-3237 |
VB |
denotes |
abolish |
T3891 |
3195-3199 |
NN |
denotes |
loss |
T3892 |
3200-3202 |
IN |
denotes |
of |
T3893 |
3203-3207 |
DT |
denotes |
this |
T3894 |
3216-3223 |
NN |
denotes |
subunit |
T3895 |
3208-3215 |
NN |
denotes |
calpain |
T3896 |
3224-3229 |
MD |
denotes |
would |
T3897 |
3238-3246 |
NN |
denotes |
activity |
T3898 |
3247-3249 |
IN |
denotes |
of |
T3899 |
3250-3254 |
CC |
denotes |
both |
T3900 |
3255-3256 |
NN |
denotes |
μ |
T3901 |
3264-3271 |
NN |
denotes |
calpain |
T3902 |
3256-3257 |
HYPH |
denotes |
- |
T3903 |
3258-3261 |
CC |
denotes |
and |
T3904 |
3262-3263 |
NN |
denotes |
m |
T3905 |
3263-3264 |
HYPH |
denotes |
- |
T3906 |
3271-3272 |
. |
denotes |
. |
T3907 |
3272-3425 |
sentence |
denotes |
Capn4-/- murine embryos died between days 10 and 11 of gestation, and there was no detectable μ- or m-calpain activity in these or younger embryos [31]. |
T3908 |
3273-3278 |
NN |
denotes |
Capn4 |
T3909 |
3289-3296 |
NNS |
denotes |
embryos |
T3910 |
3278-3279 |
SYM |
denotes |
- |
T3911 |
3279-3280 |
HYPH |
denotes |
/ |
T3912 |
3280-3281 |
SYM |
denotes |
- |
T3913 |
3282-3288 |
JJ |
denotes |
murine |
T3914 |
3297-3301 |
VBD |
denotes |
died |
T3915 |
3302-3309 |
IN |
denotes |
between |
T3916 |
3310-3314 |
NNS |
denotes |
days |
T3917 |
3315-3317 |
CD |
denotes |
10 |
T3918 |
3318-3321 |
CC |
denotes |
and |
T3919 |
3322-3324 |
CD |
denotes |
11 |
T3920 |
3325-3327 |
IN |
denotes |
of |
T3921 |
3328-3337 |
NN |
denotes |
gestation |
T3922 |
3337-3339 |
, |
denotes |
, |
T3923 |
3339-3342 |
CC |
denotes |
and |
T3924 |
3343-3348 |
EX |
denotes |
there |
T3925 |
3349-3352 |
VBD |
denotes |
was |
T3926 |
3353-3355 |
DT |
denotes |
no |
T3927 |
3383-3391 |
NN |
denotes |
activity |
T3928 |
3356-3366 |
JJ |
denotes |
detectable |
T3929 |
3367-3368 |
NN |
denotes |
μ |
T3930 |
3375-3382 |
NN |
denotes |
calpain |
T3931 |
3368-3369 |
HYPH |
denotes |
- |
T3932 |
3370-3372 |
CC |
denotes |
or |
T3933 |
3373-3374 |
NN |
denotes |
m |
T3934 |
3374-3375 |
HYPH |
denotes |
- |
T3935 |
3392-3394 |
IN |
denotes |
in |
T3936 |
3395-3400 |
DT |
denotes |
these |
T3937 |
3401-3403 |
CC |
denotes |
or |
T3938 |
3404-3411 |
JJR |
denotes |
younger |
T3939 |
3412-3419 |
NNS |
denotes |
embryos |
T3940 |
3420-3421 |
-LRB- |
denotes |
[ |
T3941 |
3421-3423 |
CD |
denotes |
31 |
T3942 |
3423-3424 |
-RRB- |
denotes |
] |
T3943 |
3424-3425 |
. |
denotes |
. |
T3944 |
3425-3758 |
sentence |
denotes |
Capn4-/- murine embryonic fibroblasts (MEFs) could be cultured from these embryos, although they also lacked calpain activity as assessed by casein zymography or by the formation of characteristic spectrin breakdown products, and they displayed migration defects consistent with a role for calpain in release of focal adhesions [9]. |
T3945 |
3426-3431 |
NN |
denotes |
Capn4 |
T3946 |
3480-3488 |
VBN |
denotes |
cultured |
T3947 |
3431-3432 |
SYM |
denotes |
- |
T3948 |
3432-3433 |
HYPH |
denotes |
/ |
T3949 |
3433-3434 |
SYM |
denotes |
- |
T3950 |
3435-3441 |
JJ |
denotes |
murine |
T3951 |
3452-3463 |
NNS |
denotes |
fibroblasts |
T3952 |
3442-3451 |
JJ |
denotes |
embryonic |
T3953 |
3464-3465 |
-LRB- |
denotes |
( |
T3954 |
3465-3469 |
NNS |
denotes |
MEFs |
T3955 |
3469-3470 |
-RRB- |
denotes |
) |
T3956 |
3471-3476 |
MD |
denotes |
could |
T3957 |
3477-3479 |
VB |
denotes |
be |
T3958 |
3489-3493 |
IN |
denotes |
from |
T3959 |
3494-3499 |
DT |
denotes |
these |
T3960 |
3500-3507 |
NNS |
denotes |
embryos |
T3961 |
3507-3509 |
, |
denotes |
, |
T3962 |
3509-3517 |
IN |
denotes |
although |
T3963 |
3528-3534 |
VBD |
denotes |
lacked |
T3964 |
3518-3522 |
PRP |
denotes |
they |
T3965 |
3523-3527 |
RB |
denotes |
also |
T3966 |
3535-3542 |
NN |
denotes |
calpain |
T3967 |
3543-3551 |
NN |
denotes |
activity |
T3968 |
3552-3554 |
IN |
denotes |
as |
T3969 |
3555-3563 |
VBN |
denotes |
assessed |
T3970 |
3564-3566 |
IN |
denotes |
by |
T3971 |
3567-3573 |
NN |
denotes |
casein |
T3972 |
3574-3584 |
NN |
denotes |
zymography |
T3973 |
3585-3587 |
CC |
denotes |
or |
T3974 |
3588-3590 |
IN |
denotes |
by |
T3975 |
3591-3594 |
DT |
denotes |
the |
T3976 |
3595-3604 |
NN |
denotes |
formation |
T3977 |
3605-3607 |
IN |
denotes |
of |
T3978 |
3608-3622 |
JJ |
denotes |
characteristic |
T3979 |
3642-3650 |
NNS |
denotes |
products |
T3980 |
3623-3631 |
NN |
denotes |
spectrin |
T3981 |
3632-3641 |
NN |
denotes |
breakdown |
T3982 |
3650-3652 |
, |
denotes |
, |
T3983 |
3652-3655 |
CC |
denotes |
and |
T3984 |
3656-3660 |
PRP |
denotes |
they |
T3985 |
3661-3670 |
VBD |
denotes |
displayed |
T3986 |
3671-3680 |
NN |
denotes |
migration |
T3987 |
3681-3688 |
NNS |
denotes |
defects |
T3988 |
3689-3699 |
JJ |
denotes |
consistent |
T3989 |
3700-3704 |
IN |
denotes |
with |
T3990 |
3705-3706 |
DT |
denotes |
a |
T3991 |
3707-3711 |
NN |
denotes |
role |
T3992 |
3712-3715 |
IN |
denotes |
for |
T3993 |
3716-3723 |
NN |
denotes |
calpain |
T3994 |
3724-3726 |
IN |
denotes |
in |
T3995 |
3727-3734 |
NN |
denotes |
release |
T3996 |
3735-3737 |
IN |
denotes |
of |
T3997 |
3738-3743 |
JJ |
denotes |
focal |
T3998 |
3744-3753 |
NNS |
denotes |
adhesions |
T3999 |
3754-3755 |
-LRB- |
denotes |
[ |
T4000 |
3755-3756 |
CD |
denotes |
9 |
T4001 |
3756-3757 |
-RRB- |
denotes |
] |
T4002 |
3757-3758 |
. |
denotes |
. |
T4003 |
3758-3937 |
sentence |
denotes |
An independently derived Capn4 knockout, involving a more extensive deletion of the gene, resulted in an earlier embryonic lethality, apparently at a pre-implantation stage [32]. |
T4004 |
3759-3761 |
DT |
denotes |
An |
T4005 |
3790-3798 |
NN |
denotes |
knockout |
T4006 |
3762-3775 |
RB |
denotes |
independently |
T4007 |
3776-3783 |
VBN |
denotes |
derived |
T4008 |
3784-3789 |
NN |
denotes |
Capn4 |
T4009 |
3849-3857 |
VBD |
denotes |
resulted |
T4010 |
3798-3800 |
, |
denotes |
, |
T4011 |
3800-3809 |
VBG |
denotes |
involving |
T4012 |
3810-3811 |
DT |
denotes |
a |
T4013 |
3827-3835 |
NN |
denotes |
deletion |
T4014 |
3812-3816 |
RBR |
denotes |
more |
T4015 |
3817-3826 |
JJ |
denotes |
extensive |
T4016 |
3836-3838 |
IN |
denotes |
of |
T4017 |
3839-3842 |
DT |
denotes |
the |
T4018 |
3843-3847 |
NN |
denotes |
gene |
T4019 |
3847-3849 |
, |
denotes |
, |
T4020 |
3858-3860 |
IN |
denotes |
in |
T4021 |
3861-3863 |
DT |
denotes |
an |
T4022 |
3882-3891 |
NN |
denotes |
lethality |
T4023 |
3864-3871 |
JJR |
denotes |
earlier |
T4024 |
3872-3881 |
JJ |
denotes |
embryonic |
T4025 |
3891-3893 |
, |
denotes |
, |
T4026 |
3893-3903 |
RB |
denotes |
apparently |
T4027 |
3904-3906 |
IN |
denotes |
at |
T4028 |
3907-3908 |
DT |
denotes |
a |
T4029 |
3926-3931 |
NN |
denotes |
stage |
T4030 |
3909-3925 |
JJ |
denotes |
pre-implantation |
T4031 |
3932-3933 |
-LRB- |
denotes |
[ |
T4032 |
3933-3935 |
CD |
denotes |
32 |
T4033 |
3935-3936 |
-RRB- |
denotes |
] |
T4034 |
3936-3937 |
. |
denotes |
. |
T4035 |
3937-4254 |
sentence |
denotes |
The different times of embryonic lethality suggested that the first reported Capn4-/- mice [31] were targeted with a hypomorphic mutation, which retained some small level of calpain activity, allowing for their survival to mid-gestation, while the second reported Capn4-/- mice [32] represented a true null mutation. |
T4036 |
3938-3941 |
DT |
denotes |
The |
T4037 |
3952-3957 |
NNS |
denotes |
times |
T4038 |
3942-3951 |
JJ |
denotes |
different |
T4039 |
3981-3990 |
VBD |
denotes |
suggested |
T4040 |
3958-3960 |
IN |
denotes |
of |
T4041 |
3961-3970 |
JJ |
denotes |
embryonic |
T4042 |
3971-3980 |
NN |
denotes |
lethality |
T4043 |
3991-3995 |
IN |
denotes |
that |
T4044 |
4039-4047 |
VBN |
denotes |
targeted |
T4045 |
3996-3999 |
DT |
denotes |
the |
T4046 |
4024-4028 |
NNS |
denotes |
mice |
T4047 |
4000-4005 |
JJ |
denotes |
first |
T4048 |
4006-4014 |
VBN |
denotes |
reported |
T4049 |
4015-4020 |
NN |
denotes |
Capn4 |
T4050 |
4020-4021 |
SYM |
denotes |
- |
T4051 |
4021-4022 |
HYPH |
denotes |
/ |
T4052 |
4022-4023 |
SYM |
denotes |
- |
T4053 |
4029-4030 |
-LRB- |
denotes |
[ |
T4054 |
4030-4032 |
CD |
denotes |
31 |
T4055 |
4032-4033 |
-RRB- |
denotes |
] |
T4056 |
4034-4038 |
VBD |
denotes |
were |
T4057 |
4048-4052 |
IN |
denotes |
with |
T4058 |
4053-4054 |
DT |
denotes |
a |
T4059 |
4067-4075 |
NN |
denotes |
mutation |
T4060 |
4055-4066 |
JJ |
denotes |
hypomorphic |
T4061 |
4075-4077 |
, |
denotes |
, |
T4062 |
4077-4082 |
WDT |
denotes |
which |
T4063 |
4083-4091 |
VBD |
denotes |
retained |
T4064 |
4092-4096 |
DT |
denotes |
some |
T4065 |
4103-4108 |
NN |
denotes |
level |
T4066 |
4097-4102 |
JJ |
denotes |
small |
T4067 |
4109-4111 |
IN |
denotes |
of |
T4068 |
4112-4119 |
NN |
denotes |
calpain |
T4069 |
4120-4128 |
NN |
denotes |
activity |
T4070 |
4128-4130 |
, |
denotes |
, |
T4071 |
4130-4138 |
VBG |
denotes |
allowing |
T4072 |
4139-4142 |
IN |
denotes |
for |
T4073 |
4143-4148 |
PRP$ |
denotes |
their |
T4074 |
4149-4157 |
NN |
denotes |
survival |
T4075 |
4158-4160 |
IN |
denotes |
to |
T4076 |
4161-4174 |
NN |
denotes |
mid-gestation |
T4077 |
4174-4176 |
, |
denotes |
, |
T4078 |
4176-4181 |
IN |
denotes |
while |
T4079 |
4221-4232 |
VBD |
denotes |
represented |
T4080 |
4182-4185 |
DT |
denotes |
the |
T4081 |
4211-4215 |
NNS |
denotes |
mice |
T4082 |
4186-4192 |
JJ |
denotes |
second |
T4083 |
4193-4201 |
VBN |
denotes |
reported |
T4084 |
4202-4207 |
NN |
denotes |
Capn4 |
T4085 |
4207-4208 |
SYM |
denotes |
- |
T4086 |
4208-4209 |
HYPH |
denotes |
/ |
T4087 |
4209-4210 |
SYM |
denotes |
- |
T4088 |
4216-4217 |
-LRB- |
denotes |
[ |
T4089 |
4217-4219 |
CD |
denotes |
32 |
T4090 |
4219-4220 |
-RRB- |
denotes |
] |
T4091 |
4233-4234 |
DT |
denotes |
a |
T4092 |
4245-4253 |
NN |
denotes |
mutation |
T4093 |
4235-4239 |
JJ |
denotes |
true |
T4094 |
4240-4244 |
JJ |
denotes |
null |
T4095 |
4253-4254 |
. |
denotes |
. |
T4096 |
4254-4488 |
sentence |
denotes |
Disruption of Capn1, encoding the μ-calpain catalytic subunit, was subsequently reported to result in fertile, viable mice with some mild defects in the μ-calpain rich platelets relating to their aggregation and clot retraction [33]. |
T4097 |
4255-4265 |
NN |
denotes |
Disruption |
T4098 |
4335-4343 |
VBN |
denotes |
reported |
T4099 |
4266-4268 |
IN |
denotes |
of |
T4100 |
4269-4274 |
NN |
denotes |
Capn1 |
T4101 |
4274-4276 |
, |
denotes |
, |
T4102 |
4276-4284 |
VBG |
denotes |
encoding |
T4103 |
4285-4288 |
DT |
denotes |
the |
T4104 |
4309-4316 |
NN |
denotes |
subunit |
T4105 |
4289-4290 |
NN |
denotes |
μ |
T4106 |
4291-4298 |
NN |
denotes |
calpain |
T4107 |
4290-4291 |
HYPH |
denotes |
- |
T4108 |
4299-4308 |
JJ |
denotes |
catalytic |
T4109 |
4316-4318 |
, |
denotes |
, |
T4110 |
4318-4321 |
VBD |
denotes |
was |
T4111 |
4322-4334 |
RB |
denotes |
subsequently |
T4112 |
4344-4346 |
TO |
denotes |
to |
T4113 |
4347-4353 |
VB |
denotes |
result |
T4114 |
4354-4356 |
IN |
denotes |
in |
T4115 |
4357-4364 |
JJ |
denotes |
fertile |
T4116 |
4373-4377 |
NNS |
denotes |
mice |
T4117 |
4364-4366 |
, |
denotes |
, |
T4118 |
4366-4372 |
JJ |
denotes |
viable |
T4119 |
4378-4382 |
IN |
denotes |
with |
T4120 |
4383-4387 |
DT |
denotes |
some |
T4121 |
4393-4400 |
NNS |
denotes |
defects |
T4122 |
4388-4392 |
JJ |
denotes |
mild |
T4123 |
4401-4403 |
IN |
denotes |
in |
T4124 |
4404-4407 |
DT |
denotes |
the |
T4125 |
4423-4432 |
NNS |
denotes |
platelets |
T4126 |
4408-4409 |
NN |
denotes |
μ |
T4127 |
4410-4417 |
NN |
denotes |
calpain |
T4128 |
4409-4410 |
HYPH |
denotes |
- |
T4129 |
4418-4422 |
JJ |
denotes |
rich |
T4130 |
4433-4441 |
VBG |
denotes |
relating |
T4131 |
4442-4444 |
IN |
denotes |
to |
T4132 |
4445-4450 |
PRP$ |
denotes |
their |
T4133 |
4451-4462 |
NN |
denotes |
aggregation |
T4134 |
4463-4466 |
CC |
denotes |
and |
T4135 |
4467-4471 |
NN |
denotes |
clot |
T4136 |
4472-4482 |
NN |
denotes |
retraction |
T4137 |
4483-4484 |
-LRB- |
denotes |
[ |
T4138 |
4484-4486 |
CD |
denotes |
33 |
T4139 |
4486-4487 |
-RRB- |
denotes |
] |
T4140 |
4487-4488 |
. |
denotes |
. |
T4141 |
4488-4636 |
sentence |
denotes |
The fact that Capn4 null mice die during embryogenesis indicates that at least one of the ubiquitous calpains is essential for development to term. |
T4142 |
4489-4492 |
DT |
denotes |
The |
T4143 |
4493-4497 |
NN |
denotes |
fact |
T4144 |
4544-4553 |
VBZ |
denotes |
indicates |
T4145 |
4498-4502 |
IN |
denotes |
that |
T4146 |
4519-4522 |
VBP |
denotes |
die |
T4147 |
4503-4508 |
NN |
denotes |
Capn4 |
T4148 |
4509-4513 |
JJ |
denotes |
null |
T4149 |
4514-4518 |
NNS |
denotes |
mice |
T4150 |
4523-4529 |
IN |
denotes |
during |
T4151 |
4530-4543 |
NN |
denotes |
embryogenesis |
T4152 |
4554-4558 |
IN |
denotes |
that |
T4153 |
4599-4601 |
VBZ |
denotes |
is |
T4154 |
4559-4561 |
RB |
denotes |
at |
T4155 |
4568-4571 |
CD |
denotes |
one |
T4156 |
4562-4567 |
RBS |
denotes |
least |
T4157 |
4572-4574 |
IN |
denotes |
of |
T4158 |
4575-4578 |
DT |
denotes |
the |
T4159 |
4590-4598 |
NNS |
denotes |
calpains |
T4160 |
4579-4589 |
JJ |
denotes |
ubiquitous |
T4161 |
4602-4611 |
JJ |
denotes |
essential |
T4162 |
4612-4615 |
IN |
denotes |
for |
T4163 |
4616-4627 |
NN |
denotes |
development |
T4164 |
4628-4630 |
IN |
denotes |
to |
T4165 |
4631-4635 |
NN |
denotes |
term |
T4166 |
4635-4636 |
. |
denotes |
. |
T4167 |
4636-4899 |
sentence |
denotes |
The viability of Capn1-deficient mice does not however distinguish between two possibilities: either that m-calpain is specifically required during embryogenesis, or that either form of calpain alone is sufficient and can compensate for the absence of the other. |
T4168 |
4637-4640 |
DT |
denotes |
The |
T4169 |
4641-4650 |
NN |
denotes |
viability |
T4170 |
4692-4703 |
VB |
denotes |
distinguish |
T4171 |
4651-4653 |
IN |
denotes |
of |
T4172 |
4654-4659 |
NN |
denotes |
Capn1 |
T4173 |
4660-4669 |
JJ |
denotes |
deficient |
T4174 |
4659-4660 |
HYPH |
denotes |
- |
T4175 |
4670-4674 |
NNS |
denotes |
mice |
T4176 |
4675-4679 |
VBZ |
denotes |
does |
T4177 |
4680-4683 |
RB |
denotes |
not |
T4178 |
4684-4691 |
RB |
denotes |
however |
T4179 |
4704-4711 |
IN |
denotes |
between |
T4180 |
4712-4715 |
CD |
denotes |
two |
T4181 |
4716-4729 |
NNS |
denotes |
possibilities |
T4182 |
4729-4731 |
: |
denotes |
: |
T4183 |
4731-4737 |
CC |
denotes |
either |
T4184 |
4769-4777 |
VBN |
denotes |
required |
T4185 |
4738-4742 |
IN |
denotes |
that |
T4186 |
4743-4744 |
NN |
denotes |
m |
T4187 |
4745-4752 |
NN |
denotes |
calpain |
T4188 |
4744-4745 |
HYPH |
denotes |
- |
T4189 |
4753-4755 |
VBZ |
denotes |
is |
T4190 |
4756-4768 |
RB |
denotes |
specifically |
T4191 |
4778-4784 |
IN |
denotes |
during |
T4192 |
4785-4798 |
NN |
denotes |
embryogenesis |
T4193 |
4798-4800 |
, |
denotes |
, |
T4194 |
4800-4802 |
CC |
denotes |
or |
T4195 |
4803-4807 |
IN |
denotes |
that |
T4196 |
4837-4839 |
VBZ |
denotes |
is |
T4197 |
4808-4814 |
CC |
denotes |
either |
T4198 |
4815-4819 |
NN |
denotes |
form |
T4199 |
4820-4822 |
IN |
denotes |
of |
T4200 |
4823-4830 |
NN |
denotes |
calpain |
T4201 |
4831-4836 |
RB |
denotes |
alone |
T4202 |
4840-4850 |
JJ |
denotes |
sufficient |
T4203 |
4851-4854 |
CC |
denotes |
and |
T4204 |
4855-4858 |
MD |
denotes |
can |
T4205 |
4859-4869 |
VB |
denotes |
compensate |
T4206 |
4870-4873 |
IN |
denotes |
for |
T4207 |
4874-4877 |
DT |
denotes |
the |
T4208 |
4878-4885 |
NN |
denotes |
absence |
T4209 |
4886-4888 |
IN |
denotes |
of |
T4210 |
4889-4892 |
DT |
denotes |
the |
T4211 |
4893-4898 |
JJ |
denotes |
other |
T4212 |
4898-4899 |
. |
denotes |
. |
T4213 |
4899-5001 |
sentence |
denotes |
To resolve this question, we have now knocked out the Capn2 gene encoding the m-80 k subunit in mice. |
T4214 |
4900-4902 |
TO |
denotes |
To |
T4215 |
4903-4910 |
VB |
denotes |
resolve |
T4216 |
4938-4945 |
VBN |
denotes |
knocked |
T4217 |
4911-4915 |
DT |
denotes |
this |
T4218 |
4916-4924 |
NN |
denotes |
question |
T4219 |
4924-4926 |
, |
denotes |
, |
T4220 |
4926-4928 |
PRP |
denotes |
we |
T4221 |
4929-4933 |
VBP |
denotes |
have |
T4222 |
4934-4937 |
RB |
denotes |
now |
T4223 |
4946-4949 |
RP |
denotes |
out |
T4224 |
4950-4953 |
DT |
denotes |
the |
T4225 |
4960-4964 |
NN |
denotes |
gene |
T4226 |
4954-4959 |
NN |
denotes |
Capn2 |
T4227 |
4965-4973 |
VBG |
denotes |
encoding |
T4228 |
4974-4977 |
DT |
denotes |
the |
T4229 |
4985-4992 |
NN |
denotes |
subunit |
T4230 |
4978-4979 |
NN |
denotes |
m |
T4231 |
4983-4984 |
NN |
denotes |
k |
T4232 |
4979-4980 |
HYPH |
denotes |
- |
T4233 |
4980-4982 |
CD |
denotes |
80 |
T4234 |
4993-4995 |
IN |
denotes |
in |
T4235 |
4996-5000 |
NNS |
denotes |
mice |
T4236 |
5000-5001 |
. |
denotes |
. |
T4237 |
5001-5146 |
sentence |
denotes |
We report here that Capn2 null embryos died prior to the implantation stage, indicating that m-calpain is indispensable for early embryogenesis. |
T4238 |
5002-5004 |
PRP |
denotes |
We |
T4239 |
5005-5011 |
VBP |
denotes |
report |
T4240 |
5012-5016 |
RB |
denotes |
here |
T4241 |
5017-5021 |
IN |
denotes |
that |
T4242 |
5041-5045 |
VBD |
denotes |
died |
T4243 |
5022-5027 |
NN |
denotes |
Capn2 |
T4244 |
5028-5032 |
JJ |
denotes |
null |
T4245 |
5033-5040 |
NNS |
denotes |
embryos |
T4246 |
5046-5051 |
JJ |
denotes |
prior |
T4247 |
5052-5054 |
IN |
denotes |
to |
T4248 |
5055-5058 |
DT |
denotes |
the |
T4249 |
5072-5077 |
NN |
denotes |
stage |
T4250 |
5059-5071 |
NN |
denotes |
implantation |
T4251 |
5077-5079 |
, |
denotes |
, |
T4252 |
5079-5089 |
VBG |
denotes |
indicating |
T4253 |
5090-5094 |
IN |
denotes |
that |
T4254 |
5105-5107 |
VBZ |
denotes |
is |
T4255 |
5095-5096 |
NN |
denotes |
m |
T4256 |
5097-5104 |
NN |
denotes |
calpain |
T4257 |
5096-5097 |
HYPH |
denotes |
- |
T4258 |
5108-5121 |
JJ |
denotes |
indispensable |
T4259 |
5122-5125 |
IN |
denotes |
for |
T4260 |
5126-5131 |
JJ |
denotes |
early |
T4261 |
5132-5145 |
NN |
denotes |
embryogenesis |
T4262 |
5145-5146 |
. |
denotes |
. |
T4263 |
5146-5300 |
sentence |
denotes |
This role cannot be fulfilled by μ-calpain, which is expressed in embryonic stem (ES) cells [31] and is assumed to be present at this stage of gestation. |
T4264 |
5147-5151 |
DT |
denotes |
This |
T4265 |
5152-5156 |
NN |
denotes |
role |
T4266 |
5167-5176 |
VBN |
denotes |
fulfilled |
T4267 |
5157-5160 |
MD |
denotes |
can |
T4268 |
5160-5163 |
RB |
denotes |
not |
T4269 |
5164-5166 |
VB |
denotes |
be |
T4270 |
5177-5179 |
IN |
denotes |
by |
T4271 |
5180-5181 |
NN |
denotes |
μ |
T4272 |
5182-5189 |
NN |
denotes |
calpain |
T4273 |
5181-5182 |
HYPH |
denotes |
- |
T4274 |
5189-5191 |
, |
denotes |
, |
T4275 |
5191-5196 |
WDT |
denotes |
which |
T4276 |
5200-5209 |
VBN |
denotes |
expressed |
T4277 |
5197-5199 |
VBZ |
denotes |
is |
T4278 |
5210-5212 |
IN |
denotes |
in |
T4279 |
5213-5222 |
JJ |
denotes |
embryonic |
T4280 |
5223-5227 |
NN |
denotes |
stem |
T4281 |
5233-5238 |
NNS |
denotes |
cells |
T4282 |
5228-5229 |
-LRB- |
denotes |
( |
T4283 |
5229-5231 |
NN |
denotes |
ES |
T4284 |
5231-5232 |
-RRB- |
denotes |
) |
T4285 |
5239-5240 |
-LRB- |
denotes |
[ |
T4286 |
5240-5242 |
CD |
denotes |
31 |
T4287 |
5242-5243 |
-RRB- |
denotes |
] |
T4288 |
5244-5247 |
CC |
denotes |
and |
T4289 |
5248-5250 |
VBZ |
denotes |
is |
T4290 |
5251-5258 |
VBN |
denotes |
assumed |
T4291 |
5259-5261 |
TO |
denotes |
to |
T4292 |
5262-5264 |
VB |
denotes |
be |
T4293 |
5265-5272 |
JJ |
denotes |
present |
T4294 |
5273-5275 |
IN |
denotes |
at |
T4295 |
5276-5280 |
DT |
denotes |
this |
T4296 |
5281-5286 |
NN |
denotes |
stage |
T4297 |
5287-5289 |
IN |
denotes |
of |
T4298 |
5290-5299 |
NN |
denotes |
gestation |
T4299 |
5299-5300 |
. |
denotes |
. |
T4300 |
5300-5423 |
sentence |
denotes |
This demonstrates unequivocally that m-calpain and μ-calpain have distinct physiological roles during early embryogenesis. |
T4301 |
5301-5305 |
DT |
denotes |
This |
T4302 |
5306-5318 |
VBZ |
denotes |
demonstrates |
T4303 |
5319-5332 |
RB |
denotes |
unequivocally |
T4304 |
5333-5337 |
IN |
denotes |
that |
T4305 |
5362-5366 |
VBP |
denotes |
have |
T4306 |
5338-5339 |
NN |
denotes |
m |
T4307 |
5340-5347 |
NN |
denotes |
calpain |
T4308 |
5339-5340 |
HYPH |
denotes |
- |
T4309 |
5348-5351 |
CC |
denotes |
and |
T4310 |
5352-5353 |
NN |
denotes |
μ |
T4311 |
5354-5361 |
NN |
denotes |
calpain |
T4312 |
5353-5354 |
HYPH |
denotes |
- |
T4313 |
5367-5375 |
JJ |
denotes |
distinct |
T4314 |
5390-5395 |
NNS |
denotes |
roles |
T4315 |
5376-5389 |
JJ |
denotes |
physiological |
T4316 |
5396-5402 |
IN |
denotes |
during |
T4317 |
5403-5408 |
JJ |
denotes |
early |
T4318 |
5409-5422 |
NN |
denotes |
embryogenesis |
T4319 |
5422-5423 |
. |
denotes |
. |
R282 |
T3323 |
T3320 |
nummod |
80,k |
R287 |
T3324 |
T3320 |
punct |
),k |
R288 |
T3325 |
T3306 |
punct |
", ",encoded |
R289 |
T3326 |
T3306 |
advmod |
respectively,encoded |
R290 |
T3244 |
T3245 |
det |
The,proteases |
R291 |
T3327 |
T3301 |
punct |
", ",subunits |
R292 |
T3245 |
T3254 |
nsubj |
proteases,are |
R293 |
T3246 |
T3245 |
nummod |
two,proteases |
R294 |
T3328 |
T3329 |
dep |
that,associate |
R295 |
T3247 |
T3245 |
amod |
ubiquitous,proteases |
R296 |
T3248 |
T3249 |
npadvmod |
Ca2,dependent |
R297 |
T3329 |
T3301 |
relcl |
associate,subunits |
R298 |
T3249 |
T3245 |
amod |
dependent,proteases |
R299 |
T3250 |
T3248 |
punct |
+,Ca2 |
R300 |
T3251 |
T3249 |
punct |
-,dependent |
R301 |
T3330 |
T3329 |
prep |
with,associate |
R302 |
T3252 |
T3245 |
punct |
", ",proteases |
R303 |
T3253 |
T3245 |
compound |
cysteine,proteases |
R304 |
T3255 |
T3245 |
acl |
known,proteases |
R305 |
T3331 |
T3332 |
det |
a,subunit |
R306 |
T3256 |
T3255 |
prep |
as,known |
R307 |
T3257 |
T3258 |
compound |
μ,calpain |
R308 |
T3258 |
T3256 |
pobj |
calpain,as |
R309 |
T3332 |
T3330 |
pobj |
subunit,with |
R310 |
T3259 |
T3258 |
punct |
-,calpain |
R311 |
T3260 |
T3258 |
punct |
(,calpain |
R312 |
T3261 |
T3258 |
appos |
calpain,calpain |
R313 |
T3333 |
T3332 |
amod |
common,subunit |
R314 |
T3262 |
T3261 |
punct |
-,calpain |
R315 |
T3263 |
T3261 |
nummod |
1,calpain |
R316 |
T3264 |
T3258 |
punct |
),calpain |
R317 |
T3334 |
T3335 |
nummod |
28,kDa |
R318 |
T3265 |
T3258 |
cc |
and,calpain |
R319 |
T3335 |
T3332 |
nmod |
kDa,subunit |
R320 |
T3266 |
T3267 |
compound |
m,calpain |
R321 |
T3267 |
T3258 |
conj |
calpain,calpain |
R322 |
T3268 |
T3267 |
punct |
-,calpain |
R323 |
T3269 |
T3267 |
punct |
(,calpain |
R324 |
T3270 |
T3267 |
appos |
capain,calpain |
R325 |
T3271 |
T3270 |
punct |
-,capain |
R326 |
T3272 |
T3270 |
nummod |
2,capain |
R327 |
T3273 |
T3254 |
punct |
),are |
R328 |
T3274 |
T3254 |
punct |
", ",are |
R329 |
T3275 |
T3276 |
det |
the,members |
R330 |
T3276 |
T3254 |
attr |
members,are |
R331 |
T3277 |
T3276 |
compound |
founding,members |
R332 |
T3278 |
T3276 |
prep |
of,members |
R333 |
T3336 |
T3332 |
amod |
regulatory,subunit |
R334 |
T3279 |
T3280 |
det |
a,family |
R335 |
T3280 |
T3278 |
pobj |
family,of |
R336 |
T3281 |
T3280 |
compound |
gene,family |
R337 |
T3282 |
T3280 |
acl |
comprising,family |
R338 |
T3337 |
T3332 |
acl |
encoded,subunit |
R339 |
T3283 |
T3284 |
nummod |
13,genes |
R340 |
T3284 |
T3282 |
dobj |
genes,comprising |
R341 |
T3285 |
T3282 |
prep |
in,comprising |
R342 |
T3338 |
T3337 |
agent |
by,encoded |
R343 |
T3286 |
T3285 |
pobj |
mammals,in |
R344 |
T3287 |
T3288 |
punct |
[,1 |
R345 |
T3288 |
T3254 |
parataxis |
1,are |
R346 |
T3339 |
T3340 |
det |
the,gene |
R347 |
T3289 |
T3290 |
punct |
-,3 |
R348 |
T3290 |
T3288 |
prep |
3,1 |
R349 |
T3291 |
T3288 |
punct |
],1 |
R350 |
T3340 |
T3338 |
pobj |
gene,by |
R351 |
T3292 |
T3254 |
punct |
.,are |
R352 |
T3341 |
T3340 |
compound |
Capn4,gene |
R353 |
T3294 |
T3295 |
nsubj |
Both,are |
R354 |
T3296 |
T3297 |
amod |
heterodimeric,enzymes |
R355 |
T3342 |
T3295 |
punct |
.,are |
R356 |
T3297 |
T3295 |
attr |
enzymes,are |
R357 |
T3298 |
T3297 |
acl |
consisting,enzymes |
R358 |
T3299 |
T3298 |
prep |
of,consisting |
R359 |
T3344 |
T3345 |
det |
The,subunits |
R360 |
T3300 |
T3301 |
amod |
distinct,subunits |
R361 |
T3301 |
T3299 |
pobj |
subunits,of |
R362 |
T3302 |
T3303 |
nummod |
80,kDa |
R363 |
T3303 |
T3301 |
nmod |
kDa,subunits |
R364 |
T3345 |
T3355 |
nsubj |
subunits,share |
R365 |
T3304 |
T3301 |
amod |
catalytic,subunits |
R366 |
T3305 |
T3301 |
punct |
", ",subunits |
R367 |
T3346 |
T3347 |
nmod |
μ,k |
R368 |
T3347 |
T3345 |
nmod |
k,subunits |
R369 |
T3306 |
T3301 |
acl |
encoded,subunits |
R370 |
T3307 |
T3306 |
agent |
by,encoded |
R371 |
T3348 |
T3346 |
punct |
-,μ |
R372 |
T3308 |
T3309 |
det |
the,genes |
R373 |
T3309 |
T3307 |
pobj |
genes,by |
R374 |
T3310 |
T3309 |
nmod |
Capn1,genes |
R375 |
T3311 |
T3312 |
punct |
(,k |
R376 |
T3349 |
T3346 |
nummod |
80,μ |
R377 |
T3312 |
T3310 |
parataxis |
k,Capn1 |
R378 |
T3313 |
T3312 |
nmod |
μ,k |
R379 |
T3314 |
T3312 |
punct |
-,k |
R380 |
T3315 |
T3312 |
nummod |
80,k |
R381 |
T3350 |
T3347 |
cc |
and,k |
R382 |
T3316 |
T3312 |
punct |
),k |
R383 |
T3317 |
T3310 |
cc |
and,Capn1 |
R384 |
T3318 |
T3310 |
conj |
Capn2,Capn1 |
R385 |
T3351 |
T3352 |
nmod |
m,k |
R386 |
T3319 |
T3320 |
punct |
(,k |
R387 |
T3320 |
T3318 |
parataxis |
k,Capn2 |
R388 |
T3321 |
T3320 |
nmod |
m,k |
R389 |
T3352 |
T3347 |
conj |
k,k |
R390 |
T3322 |
T3320 |
punct |
-,k |
R391 |
T3353 |
T3351 |
punct |
-,m |
R392 |
T3354 |
T3351 |
nummod |
80,m |
R393 |
T3356 |
T3357 |
nummod |
62,% |
R394 |
T3429 |
T3419 |
punct |
;,levels |
R395 |
T3357 |
T3358 |
compound |
%,identity |
R396 |
T3430 |
T3431 |
quantmod |
10,50 |
R397 |
T3431 |
T3433 |
nummod |
50,μM |
R398 |
T3358 |
T3355 |
dobj |
identity,share |
R399 |
T3432 |
T3431 |
punct |
–,50 |
R400 |
T3433 |
T3434 |
compound |
μM,Ca2 |
R401 |
T3434 |
T3419 |
appos |
Ca2,levels |
R402 |
T3359 |
T3360 |
compound |
amino,acid |
R403 |
T3435 |
T3434 |
punct |
+,Ca2 |
R404 |
T3436 |
T3434 |
prep |
for,Ca2 |
R405 |
T3437 |
T3438 |
compound |
μ,calpain |
R406 |
T3360 |
T3358 |
compound |
acid,identity |
R407 |
T3438 |
T3436 |
pobj |
calpain,for |
R408 |
T3439 |
T3438 |
punct |
-,calpain |
R409 |
T3440 |
T3434 |
cc |
and,Ca2 |
R410 |
T3361 |
T3358 |
compound |
sequence,identity |
R411 |
T3441 |
T3442 |
quantmod |
0.3,0.35 |
R412 |
T3442 |
T3444 |
nummod |
0.35,mM |
R413 |
T3443 |
T3442 |
punct |
–,0.35 |
R414 |
T3362 |
T3355 |
punct |
", ",share |
R415 |
T3444 |
T3445 |
compound |
mM,Ca2 |
R416 |
T3445 |
T3434 |
conj |
Ca2,Ca2 |
R417 |
T3363 |
T3355 |
cc |
and,share |
R418 |
T3446 |
T3445 |
punct |
+,Ca2 |
R419 |
T3447 |
T3445 |
prep |
for,Ca2 |
R420 |
T3448 |
T3449 |
compound |
m,calpain |
R421 |
T3449 |
T3447 |
pobj |
calpain,for |
R422 |
T3364 |
T3355 |
conj |
are,share |
R423 |
T3450 |
T3449 |
punct |
-,calpain |
R424 |
T3451 |
T3416 |
punct |
.,derive |
R425 |
T3453 |
T3454 |
nsubjpass |
It,assumed |
R426 |
T3365 |
T3366 |
advmod |
very,similar |
R427 |
T3455 |
T3454 |
auxpass |
is,assumed |
R428 |
T3456 |
T3454 |
advmod |
generally,assumed |
R429 |
T3457 |
T3458 |
mark |
that,maintain |
R430 |
T3366 |
T3364 |
acomp |
similar,are |
R431 |
T3458 |
T3454 |
ccomp |
maintain,assumed |
R432 |
T3459 |
T3460 |
nmod |
μ,calpain |
R433 |
T3367 |
T3364 |
prep |
in,are |
R434 |
T3460 |
T3458 |
nsubj |
calpain,maintain |
R435 |
T3461 |
T3459 |
punct |
-,μ |
R436 |
T3462 |
T3459 |
cc |
and,μ |
R437 |
T3463 |
T3459 |
conj |
m,μ |
R438 |
T3368 |
T3367 |
pobj |
terms,in |
R439 |
T3464 |
T3460 |
punct |
-,calpain |
R440 |
T3465 |
T3466 |
poss |
their,sensitivities |
R441 |
T3466 |
T3458 |
dobj |
sensitivities,maintain |
R442 |
T3369 |
T3368 |
prep |
of,terms |
R443 |
T3467 |
T3466 |
amod |
differential,sensitivities |
R444 |
T3468 |
T3466 |
prep |
to,sensitivities |
R445 |
T3370 |
T3369 |
pobj |
structure,of |
R446 |
T3469 |
T3468 |
pobj |
calcium,to |
R447 |
T3470 |
T3471 |
advmod |
in,vivo |
R448 |
T3471 |
T3458 |
advmod |
vivo,maintain |
R449 |
T3371 |
T3370 |
punct |
", ",structure |
R450 |
T3472 |
T3458 |
punct |
", ",maintain |
R451 |
T3473 |
T3474 |
mark |
although,demonstrated |
R452 |
T3372 |
T3373 |
compound |
protein,chemistry |
R453 |
T3373 |
T3370 |
conj |
chemistry,structure |
R454 |
T3474 |
T3458 |
advcl |
demonstrated,maintain |
R455 |
T3475 |
T3474 |
nsubjpass |
this,demonstrated |
R456 |
T3476 |
T3474 |
aux |
has,demonstrated |
R457 |
T3374 |
T3373 |
punct |
", ",chemistry |
R458 |
T3477 |
T3474 |
neg |
not,demonstrated |
R459 |
T3478 |
T3474 |
advmod |
yet,demonstrated |
R460 |
T3375 |
T3373 |
cc |
and,chemistry |
R461 |
T3479 |
T3474 |
auxpass |
been,demonstrated |
R462 |
T3480 |
T3474 |
advmod |
strictly,demonstrated |
R463 |
T3481 |
T3454 |
punct |
.,assumed |
R464 |
T3376 |
T3377 |
advmod |
in,vitro |
R465 |
T3483 |
T3484 |
advmod |
Furthermore,assumed |
R466 |
T3377 |
T3378 |
amod |
vitro,specificity |
R467 |
T3485 |
T3484 |
punct |
", ",assumed |
R468 |
T3486 |
T3487 |
mark |
since,is |
R469 |
T3378 |
T3373 |
conj |
specificity,chemistry |
R470 |
T3487 |
T3484 |
advcl |
is,assumed |
R471 |
T3488 |
T3489 |
det |
the,concentration |
R472 |
T3379 |
T3378 |
compound |
substrate,specificity |
R473 |
T3489 |
T3487 |
nsubj |
concentration,is |
R474 |
T3490 |
T3491 |
amod |
cytoplasmic,free |
R475 |
T3491 |
T3489 |
amod |
free,concentration |
R476 |
T3380 |
T3355 |
punct |
.,share |
R477 |
T3492 |
T3489 |
nmod |
Ca2,concentration |
R478 |
T3493 |
T3492 |
punct |
+,Ca2 |
R479 |
T3494 |
T3487 |
advmod |
typically,is |
R480 |
T3495 |
T3496 |
amod |
less,1 |
R481 |
T3496 |
T3498 |
nummod |
1,μM |
R482 |
T3497 |
T3496 |
quantmod |
than,1 |
R483 |
T3382 |
T3383 |
prep |
Despite,suggest |
R484 |
T3498 |
T3487 |
attr |
μM,is |
R485 |
T3499 |
T3484 |
punct |
", ",assumed |
R486 |
T3500 |
T3484 |
nsubjpass |
it,assumed |
R487 |
T3501 |
T3484 |
auxpass |
is,assumed |
R488 |
T3384 |
T3385 |
det |
these,similarities |
R489 |
T3502 |
T3484 |
advmod |
also,assumed |
R490 |
T3503 |
T3504 |
mark |
that,contribute |
R491 |
T3504 |
T3484 |
ccomp |
contribute,assumed |
R492 |
T3505 |
T3506 |
amod |
other,factors |
R493 |
T3506 |
T3504 |
nsubj |
factors,contribute |
R494 |
T3385 |
T3382 |
pobj |
similarities,Despite |
R495 |
T3507 |
T3508 |
advmod |
in,vivo |
R496 |
T3508 |
T3506 |
amod |
vivo,factors |
R497 |
T3509 |
T3504 |
aux |
must,contribute |
R498 |
T3510 |
T3504 |
prep |
to,contribute |
R499 |
T3386 |
T3383 |
punct |
", ",suggest |
R500 |
T3511 |
T3510 |
pobj |
regulation,to |
R501 |
T3512 |
T3511 |
prep |
of,regulation |
R502 |
T3387 |
T3388 |
det |
the,patterns |
R503 |
T3513 |
T3514 |
det |
these,enzymes |
R504 |
T3514 |
T3512 |
pobj |
enzymes,of |
R505 |
T3515 |
T3516 |
punct |
[,3 |
R506 |
T3388 |
T3383 |
nsubj |
patterns,suggest |
R507 |
T3516 |
T3504 |
parataxis |
3,contribute |
R508 |
T3517 |
T3516 |
punct |
],3 |
R509 |
T3518 |
T3484 |
punct |
.,assumed |
R510 |
T3520 |
T3521 |
prep |
Without,presents |
R511 |
T3389 |
T3388 |
amod |
differential,patterns |
R512 |
T3522 |
T3523 |
nmod |
apriori,knowledge |
R513 |
T3523 |
T3520 |
pobj |
knowledge,Without |
R514 |
T3390 |
T3388 |
compound |
expression,patterns |
R515 |
T3524 |
T3523 |
prep |
of,knowledge |
R516 |
T3525 |
T3526 |
det |
the,factors |
R517 |
T3526 |
T3524 |
pobj |
factors,of |
R518 |
T3391 |
T3388 |
prep |
of,patterns |
R519 |
T3527 |
T3526 |
acl |
regulating,factors |
R520 |
T3528 |
T3529 |
compound |
calpain,activity |
R521 |
T3529 |
T3527 |
dobj |
activity,regulating |
R522 |
T3392 |
T3393 |
nmod |
μ,calpain |
R523 |
T3530 |
T3526 |
cc |
or,factors |
R524 |
T3531 |
T3532 |
poss |
their,substrates |
R525 |
T3532 |
T3526 |
conj |
substrates,factors |
R526 |
T3393 |
T3391 |
pobj |
calpain,of |
R527 |
T3533 |
T3532 |
amod |
relevant,substrates |
R528 |
T3534 |
T3521 |
punct |
", ",presents |
R529 |
T3394 |
T3392 |
punct |
-,μ |
R530 |
T3535 |
T3521 |
nsubj |
elucidation,presents |
R531 |
T3395 |
T3392 |
cc |
and,μ |
R532 |
T3536 |
T3535 |
prep |
of,elucidation |
R533 |
T3537 |
T3538 |
amod |
biological,functions |
R534 |
T3538 |
T3536 |
pobj |
functions,of |
R535 |
T3539 |
T3535 |
prep |
for,elucidation |
R536 |
T3396 |
T3392 |
conj |
m,μ |
R537 |
T3540 |
T3539 |
pobj |
calpains,for |
R538 |
T3541 |
T3542 |
det |
a,challenge |
R539 |
T3542 |
T3521 |
dobj |
challenge,presents |
R540 |
T3397 |
T3393 |
punct |
-,calpain |
R541 |
T3543 |
T3521 |
punct |
.,presents |
R542 |
T3398 |
T3388 |
prep |
in,patterns |
R543 |
T3545 |
T3546 |
nsubj |
Research,linked |
R544 |
T3547 |
T3545 |
prep |
on,Research |
R545 |
T3399 |
T3400 |
amod |
mammalian,tissues |
R546 |
T3548 |
T3547 |
pobj |
calpains,on |
R547 |
T3549 |
T3546 |
aux |
has,linked |
R548 |
T3550 |
T3546 |
dobj |
them,linked |
R549 |
T3400 |
T3398 |
pobj |
tissues,in |
R550 |
T3551 |
T3546 |
prep |
with,linked |
R551 |
T3552 |
T3553 |
det |
a,variety |
R552 |
T3401 |
T3402 |
nsubj |
they,have |
R553 |
T3553 |
T3551 |
pobj |
variety,with |
R554 |
T3554 |
T3553 |
amod |
wide,variety |
R555 |
T3555 |
T3553 |
prep |
of,variety |
R556 |
T3402 |
T3383 |
advcl |
have,suggest |
R557 |
T3556 |
T3555 |
pobj |
functions,of |
R558 |
T3557 |
T3553 |
prep |
including,variety |
R559 |
T3558 |
T3559 |
compound |
muscle,growth |
R560 |
T3403 |
T3404 |
det |
some,functions |
R561 |
T3559 |
T3557 |
pobj |
growth,including |
R562 |
T3404 |
T3402 |
dobj |
functions,have |
R563 |
T3560 |
T3559 |
punct |
", ",growth |
R564 |
T3405 |
T3406 |
npadvmod |
isoform,specific |
R565 |
T3561 |
T3559 |
conj |
development,growth |
R566 |
T3562 |
T3561 |
punct |
", ",development |
R567 |
T3563 |
T3561 |
conj |
degeneration,development |
R568 |
T3406 |
T3404 |
amod |
specific,functions |
R569 |
T3564 |
T3565 |
punct |
(,3 |
R570 |
T3407 |
T3406 |
cc |
and,specific |
R571 |
T3565 |
T3563 |
parataxis |
3,degeneration |
R572 |
T3408 |
T3406 |
conj |
distinct,specific |
R573 |
T3566 |
T3565 |
punct |
),3 |
R574 |
T3567 |
T3563 |
punct |
", ",degeneration |
R575 |
T3409 |
T3383 |
punct |
.,suggest |
R578 |
T3411 |
T3412 |
det |
The,designations |
R579 |
T3570 |
T3569 |
cc |
and,growth |
R580 |
T3571 |
T3569 |
conj |
neurodegeneration,growth |
R581 |
T3572 |
T3573 |
punct |
[,4 |
R582 |
T3573 |
T3571 |
parataxis |
4,neurodegeneration |
R583 |
T3574 |
T3573 |
punct |
],4 |
R584 |
T3575 |
T3569 |
punct |
", ",growth |
R585 |
T3576 |
T3577 |
compound |
cell,cycle |
R586 |
T3412 |
T3416 |
nsubj |
designations,derive |
R587 |
T3577 |
T3578 |
compound |
cycle,progression |
R588 |
T3578 |
T3569 |
conj |
progression,growth |
R589 |
T3413 |
T3412 |
nmod |
μ,designations |
R590 |
T3579 |
T3580 |
punct |
[,6 |
R591 |
T3580 |
T3578 |
parataxis |
6,progression |
R592 |
T3581 |
T3580 |
nummod |
5,6 |
R593 |
T3414 |
T3413 |
cc |
and,μ |
R594 |
T3582 |
T3580 |
punct |
",",6 |
R595 |
T3583 |
T3580 |
punct |
],6 |
R596 |
T3584 |
T3578 |
punct |
", ",progression |
R597 |
T3415 |
T3413 |
conj |
m,μ |
R598 |
T3585 |
T3586 |
compound |
signal,cascades |
R599 |
T3586 |
T3578 |
conj |
cascades,progression |
R600 |
T3587 |
T3586 |
acl |
triggered,cascades |
R601 |
T3417 |
T3416 |
prep |
from,derive |
R602 |
T3588 |
T3587 |
agent |
by,triggered |
R603 |
T3589 |
T3588 |
pobj |
integrins,by |
R604 |
T3590 |
T3589 |
cc |
and,integrins |
R605 |
T3591 |
T3592 |
compound |
growth,factors |
R606 |
T3418 |
T3419 |
det |
the,levels |
R607 |
T3592 |
T3589 |
conj |
factors,integrins |
R608 |
T3593 |
T3594 |
punct |
[,7 |
R609 |
T3594 |
T3587 |
parataxis |
7,triggered |
R610 |
T3419 |
T3417 |
pobj |
levels,from |
R611 |
T3595 |
T3594 |
punct |
],7 |
R612 |
T3596 |
T3586 |
punct |
", ",cascades |
R613 |
T3597 |
T3598 |
compound |
membrane,protrusion |
R614 |
T3598 |
T3586 |
conj |
protrusion,cascades |
R615 |
T3420 |
T3419 |
prep |
of,levels |
R616 |
T3599 |
T3600 |
punct |
[,8 |
R617 |
T3600 |
T3598 |
parataxis |
8,protrusion |
R618 |
T3421 |
T3420 |
pobj |
Ca2,of |
R619 |
T3601 |
T3600 |
punct |
],8 |
R620 |
T3602 |
T3598 |
punct |
", ",protrusion |
R621 |
T3603 |
T3598 |
conj |
remodeling,protrusion |
R622 |
T3422 |
T3421 |
punct |
+,Ca2 |
R623 |
T3604 |
T3603 |
prep |
of,remodeling |
R624 |
T3605 |
T3606 |
det |
the,cytoskeleton |
R625 |
T3606 |
T3604 |
pobj |
cytoskeleton,of |
R626 |
T3423 |
T3419 |
acl |
required,levels |
R627 |
T3607 |
T3603 |
cc |
and,remodeling |
R628 |
T3608 |
T3609 |
compound |
cell,migration |
R629 |
T3609 |
T3603 |
conj |
migration,remodeling |
R630 |
T3424 |
T3425 |
advmod |
in,vitro |
R631 |
T3610 |
T3611 |
punct |
[,9 |
R632 |
T3611 |
T3609 |
parataxis |
9,migration |
R633 |
T3612 |
T3613 |
punct |
-,15 |
R634 |
T3613 |
T3611 |
appos |
15,9 |
R635 |
T3614 |
T3611 |
punct |
],9 |
R636 |
T3615 |
T3603 |
punct |
", ",remodeling |
R637 |
T3425 |
T3423 |
advmod |
vitro,required |
R638 |
T3616 |
T3603 |
cc |
and,remodeling |
R639 |
T3617 |
T3603 |
conj |
regulation,remodeling |
R640 |
T3426 |
T3423 |
prep |
for,required |
R641 |
T3618 |
T3617 |
prep |
of,regulation |
R642 |
T3619 |
T3620 |
compound |
cell,death |
R643 |
T3620 |
T3618 |
pobj |
death,of |
R644 |
T3621 |
T3617 |
prep |
via,regulation |
R645 |
T3427 |
T3428 |
amod |
optimal,activation |
R646 |
T3622 |
T3623 |
preconj |
both,necrosis |
R647 |
T3623 |
T3621 |
pobj |
necrosis,via |
R648 |
T3624 |
T3623 |
cc |
and,necrosis |
R649 |
T3428 |
T3426 |
pobj |
activation,for |
R650 |
T3625 |
T3623 |
conj |
apoptosis,necrosis |
R651 |
T3626 |
T3627 |
punct |
[,16 |
R652 |
T3627 |
T3617 |
parataxis |
16,regulation |
R653 |
T3640 |
T3634 |
dobj |
interplay,suggests |
R654 |
T3628 |
T3629 |
punct |
-,22 |
R655 |
T3629 |
T3627 |
appos |
22,16 |
R656 |
T3630 |
T3627 |
punct |
],16 |
R657 |
T3631 |
T3546 |
punct |
.,linked |
R658 |
T3641 |
T3640 |
amod |
complex,interplay |
R659 |
T3633 |
T3634 |
prep |
To,suggests |
R660 |
T3642 |
T3640 |
prep |
between,interplay |
R661 |
T3635 |
T3633 |
pobj |
date,To |
R662 |
T3636 |
T3634 |
punct |
", ",suggests |
R663 |
T3643 |
T3642 |
pobj |
caspases,between |
R664 |
T3637 |
T3638 |
det |
the,literature |
R665 |
T3638 |
T3634 |
nsubj |
literature,suggests |
R666 |
T3639 |
T3640 |
det |
a,interplay |
R667 |
T3644 |
T3643 |
cc |
and,caspases |
R668 |
T3645 |
T3643 |
conj |
calpains,caspases |
R669 |
T3646 |
T3647 |
punct |
[,24 |
R670 |
T3647 |
T3640 |
parataxis |
24,interplay |
R671 |
T3746 |
T3745 |
punct |
-,calpain |
R672 |
T3747 |
T3742 |
prep |
in,role |
R673 |
T3648 |
T3647 |
nummod |
23,24 |
R674 |
T3748 |
T3749 |
amod |
epidermal,factor |
R675 |
T3749 |
T3751 |
npadvmod |
factor,induced |
R676 |
T3750 |
T3749 |
compound |
growth,factor |
R677 |
T3649 |
T3647 |
punct |
",",24 |
R678 |
T3751 |
T3756 |
amod |
induced,motility |
R679 |
T3752 |
T3749 |
punct |
(,factor |
R680 |
T3650 |
T3647 |
punct |
],24 |
R681 |
T3753 |
T3749 |
appos |
EGF,factor |
R682 |
T3754 |
T3751 |
punct |
),induced |
R683 |
T3755 |
T3751 |
punct |
-,induced |
R684 |
T3651 |
T3640 |
cc |
and,interplay |
R685 |
T3756 |
T3747 |
pobj |
motility,in |
R686 |
T3757 |
T3756 |
compound |
cell,motility |
R687 |
T3758 |
T3759 |
punct |
[,29 |
R688 |
T3759 |
T3742 |
parataxis |
29,role |
R689 |
T3760 |
T3759 |
nummod |
28,29 |
R690 |
T3761 |
T3759 |
punct |
",",29 |
R691 |
T3652 |
T3640 |
conj |
impact,interplay |
R692 |
T3762 |
T3759 |
punct |
],29 |
R693 |
T3763 |
T3742 |
cc |
and,role |
R694 |
T3764 |
T3765 |
det |
a,role |
R695 |
T3653 |
T3652 |
prep |
of,impact |
R696 |
T3765 |
T3742 |
conj |
role,role |
R697 |
T3766 |
T3765 |
prep |
for,role |
R698 |
T3654 |
T3653 |
pobj |
calpain,of |
R699 |
T3767 |
T3768 |
compound |
μ,calpain |
R700 |
T3768 |
T3766 |
pobj |
calpain,for |
R701 |
T3769 |
T3768 |
punct |
-,calpain |
R702 |
T3655 |
T3652 |
prep |
on,impact |
R703 |
T3770 |
T3765 |
prep |
in,role |
R704 |
T3771 |
T3772 |
npadvmod |
interferon,inducible |
R705 |
T3772 |
T3774 |
amod |
inducible,migration |
R706 |
T3656 |
T3657 |
compound |
cell,death |
R707 |
T3773 |
T3772 |
punct |
-,inducible |
R708 |
T3774 |
T3770 |
pobj |
migration,in |
R709 |
T3775 |
T3776 |
npadvmod |
protein,induced |
R710 |
T3657 |
T3658 |
compound |
death,components |
R711 |
T3776 |
T3774 |
amod |
induced,migration |
R712 |
T3777 |
T3775 |
nummod |
9,protein |
R713 |
T3778 |
T3776 |
punct |
-,induced |
R714 |
T3658 |
T3655 |
pobj |
components,on |
R715 |
T3779 |
T3774 |
prep |
of,migration |
R716 |
T3780 |
T3779 |
pobj |
keratinocytes,of |
R717 |
T3781 |
T3782 |
punct |
[,28 |
R718 |
T3659 |
T3658 |
compound |
pathway,components |
R719 |
T3782 |
T3765 |
parataxis |
28,role |
R720 |
T3783 |
T3782 |
punct |
],28 |
R721 |
T3784 |
T3733 |
punct |
.,suggested |
R722 |
T3660 |
T3661 |
punct |
[,25 |
R723 |
T3786 |
T3787 |
det |
A,inhibitor |
R724 |
T3661 |
T3652 |
parataxis |
25,impact |
R725 |
T3787 |
T3791 |
nsubjpass |
inhibitor,used |
R726 |
T3788 |
T3789 |
npadvmod |
cell,permeable |
R727 |
T3789 |
T3787 |
amod |
permeable,inhibitor |
R728 |
T3790 |
T3787 |
compound |
calpain,inhibitor |
R729 |
T3662 |
T3661 |
punct |
],25 |
R730 |
T3792 |
T3787 |
punct |
(,inhibitor |
R731 |
T3663 |
T3634 |
punct |
.,suggests |
R732 |
T3793 |
T3794 |
dep |
which,inhibits |
R733 |
T3794 |
T3787 |
relcl |
inhibits,inhibitor |
R734 |
T3795 |
T3794 |
advmod |
likely,inhibits |
R735 |
T3665 |
T3666 |
det |
The,lack |
R736 |
T3796 |
T3797 |
amod |
other,proteases |
R737 |
T3797 |
T3794 |
dobj |
proteases,inhibits |
R738 |
T3798 |
T3797 |
compound |
thiol,proteases |
R739 |
T3799 |
T3797 |
punct |
-,proteases |
R740 |
T3800 |
T3801 |
advmod |
as,well |
R741 |
T3801 |
T3794 |
advmod |
well,inhibits |
R742 |
T3802 |
T3791 |
punct |
),used |
R743 |
T3666 |
T3667 |
nsubj |
lack,contributes |
R744 |
T3803 |
T3791 |
aux |
has,used |
R745 |
T3804 |
T3791 |
auxpass |
been,used |
R746 |
T3805 |
T3806 |
aux |
to,select |
R747 |
T3668 |
T3666 |
prep |
of,lack |
R748 |
T3806 |
T3791 |
advcl |
select,used |
R749 |
T3807 |
T3806 |
dobj |
cells,select |
R750 |
T3808 |
T3807 |
acl |
lacking,cells |
R751 |
T3809 |
T3810 |
compound |
μ,calpain |
R752 |
T3669 |
T3670 |
advmod |
highly,specific |
R753 |
T3670 |
T3671 |
amod |
specific,inhibitors |
R754 |
T3810 |
T3808 |
dobj |
calpain,lacking |
R755 |
T3671 |
T3668 |
pobj |
inhibitors,of |
R756 |
T3811 |
T3810 |
punct |
-,calpain |
R757 |
T3812 |
T3813 |
dep |
which,display |
R758 |
T3813 |
T3807 |
relcl |
display,cells |
R759 |
T3672 |
T3673 |
npadvmod |
cell,permeable |
R760 |
T3814 |
T3815 |
amod |
reduced,rates |
R761 |
T3815 |
T3813 |
dobj |
rates,display |
R762 |
T3816 |
T3815 |
compound |
proliferation,rates |
R763 |
T3673 |
T3671 |
amod |
permeable,inhibitors |
R764 |
T3817 |
T3818 |
punct |
[,30 |
R765 |
T3818 |
T3813 |
parataxis |
30,display |
R766 |
T3819 |
T3818 |
punct |
],30 |
R767 |
T3674 |
T3673 |
punct |
-,permeable |
R768 |
T3820 |
T3791 |
punct |
.,used |
R769 |
T3675 |
T3671 |
prep |
of,inhibitors |
R770 |
T3822 |
T3823 |
advmod |
Interestingly,persisted |
R771 |
T3676 |
T3675 |
pobj |
calpains,of |
R772 |
T3824 |
T3823 |
punct |
", ",persisted |
R773 |
T3825 |
T3826 |
compound |
m,calpain |
R774 |
T3826 |
T3828 |
compound |
calpain,expression |
R775 |
T3677 |
T3667 |
prep |
to,contributes |
R776 |
T3827 |
T3826 |
punct |
-,calpain |
R777 |
T3828 |
T3823 |
nsubj |
expression,persisted |
R778 |
T3829 |
T3823 |
prep |
in,persisted |
R779 |
T3678 |
T3679 |
det |
the,challenge |
R780 |
T3830 |
T3831 |
det |
these,cells |
R781 |
T3831 |
T3829 |
pobj |
cells,in |
R782 |
T3832 |
T3823 |
punct |
", ",persisted |
R783 |
T3679 |
T3677 |
pobj |
challenge,to |
R784 |
T3833 |
T3823 |
advcl |
suggesting,persisted |
R785 |
T3834 |
T3835 |
det |
a,requirement |
R786 |
T3835 |
T3833 |
dobj |
requirement,suggesting |
R787 |
T3680 |
T3679 |
prep |
of,challenge |
R788 |
T3836 |
T3835 |
amod |
possible,requirement |
R789 |
T3837 |
T3835 |
prep |
of,requirement |
R790 |
T3681 |
T3680 |
pcomp |
investigating,of |
R791 |
T3838 |
T3839 |
compound |
m,calpain |
R792 |
T3839 |
T3837 |
pobj |
calpain,of |
R793 |
T3840 |
T3839 |
punct |
-,calpain |
R794 |
T3841 |
T3835 |
prep |
for,requirement |
R795 |
T3842 |
T3843 |
compound |
cell,survival |
R796 |
T3843 |
T3841 |
pobj |
survival,for |
R797 |
T3682 |
T3681 |
cc |
and,investigating |
R798 |
T3844 |
T3845 |
punct |
[,30 |
R799 |
T3845 |
T3823 |
parataxis |
30,persisted |
R800 |
T3846 |
T3845 |
punct |
],30 |
R801 |
T3683 |
T3681 |
conj |
defining,investigating |
R802 |
T3847 |
T3823 |
punct |
.,persisted |
R803 |
T3684 |
T3685 |
compound |
calpain,functions |
R804 |
T3849 |
T3850 |
amod |
Targeted,deletion |
R805 |
T3685 |
T3683 |
dobj |
functions,defining |
R806 |
T3686 |
T3683 |
prep |
in,defining |
R807 |
T3850 |
T3852 |
nsubj |
deletion,provides |
R808 |
T3687 |
T3688 |
det |
these,processes |
R809 |
T3851 |
T3850 |
compound |
gene,deletion |
R810 |
T3853 |
T3850 |
prep |
in,deletion |
R811 |
T3688 |
T3686 |
pobj |
processes,in |
R812 |
T3854 |
T3853 |
pobj |
mice,in |
R813 |
T3855 |
T3856 |
det |
a,approach |
R814 |
T3689 |
T3667 |
punct |
.,contributes |
R815 |
T3856 |
T3852 |
dobj |
approach,provides |
R816 |
T3691 |
T3692 |
mark |
Although,provides |
R817 |
T3857 |
T3856 |
amod |
powerful,approach |
R818 |
T3858 |
T3856 |
prep |
to,approach |
R819 |
T3859 |
T3858 |
pcomp |
determining,to |
R820 |
T3860 |
T3861 |
det |
the,roles |
R821 |
T3692 |
T3708 |
advcl |
provides,distinguish |
R822 |
T3861 |
T3859 |
dobj |
roles,determining |
R823 |
T3862 |
T3861 |
amod |
physiological,roles |
R824 |
T3863 |
T3861 |
prep |
of,roles |
R825 |
T3693 |
T3692 |
nsubj |
over-expression,provides |
R826 |
T3864 |
T3865 |
nmod |
μ,calpain |
R827 |
T3865 |
T3863 |
pobj |
calpain,of |
R828 |
T3694 |
T3693 |
prep |
of,over-expression |
R829 |
T3866 |
T3864 |
punct |
-,μ |
R830 |
T3867 |
T3864 |
cc |
and,μ |
R831 |
T3868 |
T3864 |
conj |
m,μ |
R832 |
T3695 |
T3694 |
pobj |
calpastatin,of |
R833 |
T3869 |
T3865 |
punct |
-,calpain |
R834 |
T3870 |
T3856 |
cc |
and,approach |
R835 |
T3871 |
T3872 |
det |
the,opportunity |
R836 |
T3696 |
T3695 |
punct |
", ",calpastatin |
R837 |
T3872 |
T3856 |
conj |
opportunity,approach |
R838 |
T3873 |
T3874 |
aux |
to,approach |
R839 |
T3697 |
T3698 |
det |
the,inhibitor |
R840 |
T3874 |
T3872 |
acl |
approach,opportunity |
R841 |
T3875 |
T3876 |
poss |
their,functions |
R842 |
T3876 |
T3874 |
dobj |
functions,approach |
R843 |
T3877 |
T3878 |
npadvmod |
isoform,specific |
R844 |
T3878 |
T3876 |
amod |
specific,functions |
R845 |
T3879 |
T3852 |
punct |
.,provides |
R846 |
T3698 |
T3695 |
appos |
inhibitor,calpastatin |
R847 |
T3881 |
T3882 |
amod |
Initial,studies |
R848 |
T3882 |
T3883 |
nsubj |
studies,targeted |
R849 |
T3699 |
T3698 |
amod |
endogenous,inhibitor |
R850 |
T3884 |
T3883 |
dobj |
Capn4,targeted |
R851 |
T3885 |
T3883 |
prep |
based,targeted |
R852 |
T3700 |
T3698 |
compound |
protein,inhibitor |
R853 |
T3886 |
T3885 |
prep |
on,based |
R854 |
T3887 |
T3888 |
det |
the,prediction |
R855 |
T3888 |
T3886 |
pobj |
prediction,on |
R856 |
T3889 |
T3890 |
mark |
that,abolish |
R857 |
T3701 |
T3698 |
prep |
of,inhibitor |
R858 |
T3890 |
T3888 |
acl |
abolish,prediction |
R859 |
T3702 |
T3703 |
nmod |
μ,calpain |
R860 |
T3891 |
T3890 |
nsubj |
loss,abolish |
R861 |
T3892 |
T3891 |
prep |
of,loss |
R862 |
T3893 |
T3894 |
det |
this,subunit |
R863 |
T3894 |
T3892 |
pobj |
subunit,of |
R864 |
T3703 |
T3701 |
pobj |
calpain,of |
R865 |
T3895 |
T3894 |
compound |
calpain,subunit |
R866 |
T3896 |
T3890 |
aux |
would,abolish |
R867 |
T3704 |
T3702 |
punct |
-,μ |
R868 |
T3897 |
T3890 |
dobj |
activity,abolish |
R869 |
T3705 |
T3702 |
cc |
and,μ |
R870 |
T3898 |
T3897 |
prep |
of,activity |
R871 |
T3899 |
T3900 |
preconj |
both,μ |
R872 |
T3706 |
T3702 |
conj |
m,μ |
R873 |
T3900 |
T3901 |
nmod |
μ,calpain |
R874 |
T3901 |
T3898 |
pobj |
calpain,of |
R875 |
T3707 |
T3703 |
punct |
-,calpain |
R876 |
T3902 |
T3900 |
punct |
-,μ |
R877 |
T3903 |
T3900 |
cc |
and,μ |
R878 |
T3904 |
T3900 |
conj |
m,μ |
R879 |
T3709 |
T3710 |
det |
an,approach |
R880 |
T3905 |
T3901 |
punct |
-,calpain |
R881 |
T3906 |
T3883 |
punct |
.,targeted |
R882 |
T3908 |
T3909 |
nmod |
Capn4,embryos |
R883 |
T3710 |
T3692 |
dobj |
approach,provides |
R884 |
T3909 |
T3914 |
nsubj |
embryos,died |
R885 |
T3910 |
T3908 |
punct |
-,Capn4 |
R886 |
T3911 |
T3908 |
punct |
/,Capn4 |
R887 |
T3711 |
T3710 |
amod |
important,approach |
R888 |
T3912 |
T3908 |
punct |
-,Capn4 |
R889 |
T3913 |
T3909 |
amod |
murine,embryos |
R890 |
T3712 |
T3710 |
prep |
for,approach |
R891 |
T3915 |
T3914 |
prep |
between,died |
R892 |
T3916 |
T3917 |
nmod |
days,10 |
R893 |
T3713 |
T3714 |
det |
these,efforts |
R894 |
T3917 |
T3915 |
pobj |
10,between |
R895 |
T3918 |
T3917 |
cc |
and,10 |
R896 |
T3919 |
T3917 |
conj |
11,10 |
R897 |
T3920 |
T3917 |
prep |
of,10 |
R898 |
T3921 |
T3920 |
pobj |
gestation,of |
R899 |
T3922 |
T3914 |
punct |
", ",died |
R900 |
T3714 |
T3712 |
pobj |
efforts,for |
R901 |
T3923 |
T3914 |
cc |
and,died |
R902 |
T3924 |
T3925 |
expl |
there,was |
R903 |
T3925 |
T3914 |
conj |
was,died |
R904 |
T3715 |
T3708 |
punct |
", ",distinguish |
R905 |
T3926 |
T3927 |
det |
no,activity |
R906 |
T3927 |
T3925 |
attr |
activity,was |
R907 |
T3928 |
T3927 |
amod |
detectable,activity |
R908 |
T3716 |
T3708 |
nsubj |
it,distinguish |
R909 |
T3929 |
T3930 |
nmod |
μ,calpain |
R910 |
T3930 |
T3927 |
compound |
calpain,activity |
R911 |
T3931 |
T3929 |
punct |
-,μ |
R912 |
T3717 |
T3708 |
aux |
will,distinguish |
R913 |
T3932 |
T3929 |
cc |
or,μ |
R914 |
T3933 |
T3929 |
conj |
m,μ |
R915 |
T3718 |
T3708 |
neg |
not,distinguish |
R916 |
T3934 |
T3930 |
punct |
-,calpain |
R917 |
T3935 |
T3925 |
prep |
in,was |
R918 |
T3936 |
T3935 |
pobj |
these,in |
R919 |
T3937 |
T3936 |
cc |
or,these |
R920 |
T3719 |
T3720 |
npadvmod |
isoform,specific |
R921 |
T3938 |
T3939 |
amod |
younger,embryos |
R922 |
T3939 |
T3936 |
conj |
embryos,these |
R923 |
T3720 |
T3721 |
amod |
specific,functions |
R924 |
T3940 |
T3941 |
punct |
[,31 |
R925 |
T3941 |
T3925 |
parataxis |
31,was |
R926 |
T3942 |
T3941 |
punct |
],31 |
R927 |
T3721 |
T3708 |
dobj |
functions,distinguish |
R928 |
T3943 |
T3925 |
punct |
.,was |
R929 |
T3945 |
T3946 |
nsubjpass |
Capn4,cultured |
R930 |
T3722 |
T3723 |
punct |
[,27 |
R931 |
T3947 |
T3945 |
punct |
-,Capn4 |
R932 |
T3948 |
T3945 |
punct |
/,Capn4 |
R933 |
T3723 |
T3708 |
parataxis |
27,distinguish |
R934 |
T3949 |
T3945 |
punct |
-,Capn4 |
R935 |
T3950 |
T3951 |
amod |
murine,fibroblasts |
R936 |
T3724 |
T3723 |
nummod |
24,27 |
R937 |
T3725 |
T3723 |
punct |
",",27 |
R938 |
T3951 |
T3945 |
appos |
fibroblasts,Capn4 |
R939 |
T3726 |
T3723 |
nummod |
26,27 |
R940 |
T3952 |
T3951 |
amod |
embryonic,fibroblasts |
R941 |
T3727 |
T3723 |
punct |
",",27 |
R942 |
T3953 |
T3951 |
punct |
(,fibroblasts |
R943 |
T3954 |
T3951 |
appos |
MEFs,fibroblasts |
R944 |
T3728 |
T3723 |
punct |
],27 |
R945 |
T3729 |
T3708 |
punct |
.,distinguish |
R946 |
T3955 |
T3946 |
punct |
),cultured |
R947 |
T3731 |
T3732 |
det |
Some,work |
R948 |
T3956 |
T3946 |
aux |
could,cultured |
R949 |
T3957 |
T3946 |
auxpass |
be,cultured |
R950 |
T3958 |
T3946 |
prep |
from,cultured |
R951 |
T3959 |
T3960 |
det |
these,embryos |
R952 |
T3960 |
T3958 |
pobj |
embryos,from |
R953 |
T3961 |
T3946 |
punct |
", ",cultured |
R954 |
T3962 |
T3963 |
mark |
although,lacked |
R955 |
T3732 |
T3733 |
nsubj |
work,suggested |
R956 |
T3963 |
T3946 |
advcl |
lacked,cultured |
R957 |
T3964 |
T3963 |
nsubj |
they,lacked |
R958 |
T3965 |
T3963 |
advmod |
also,lacked |
R959 |
T3734 |
T3733 |
aux |
has,suggested |
R960 |
T3966 |
T3967 |
compound |
calpain,activity |
R961 |
T3967 |
T3963 |
dobj |
activity,lacked |
R962 |
T3968 |
T3969 |
mark |
as,assessed |
R963 |
T3969 |
T3963 |
advcl |
assessed,lacked |
R964 |
T3735 |
T3736 |
npadvmod |
isoform,specific |
R965 |
T3970 |
T3969 |
prep |
by,assessed |
R966 |
T3971 |
T3972 |
compound |
casein,zymography |
R967 |
T3972 |
T3970 |
pobj |
zymography,by |
R968 |
T3736 |
T3737 |
amod |
specific,roles |
R969 |
T3973 |
T3970 |
cc |
or,by |
R970 |
T3974 |
T3970 |
conj |
by,by |
R971 |
T3737 |
T3733 |
dobj |
roles,suggested |
R972 |
T3975 |
T3976 |
det |
the,formation |
R973 |
T3976 |
T3974 |
pobj |
formation,by |
R974 |
T3738 |
T3737 |
punct |
", ",roles |
R975 |
T3977 |
T3976 |
prep |
of,formation |
R976 |
T3978 |
T3979 |
amod |
characteristic,products |
R977 |
T3979 |
T3977 |
pobj |
products,of |
R978 |
T3739 |
T3740 |
amod |
such,as |
R979 |
T3980 |
T3981 |
compound |
spectrin,breakdown |
R980 |
T3981 |
T3979 |
compound |
breakdown,products |
R981 |
T3740 |
T3737 |
prep |
as,roles |
R982 |
T3741 |
T3742 |
det |
a,role |
R983 |
T3982 |
T3963 |
punct |
", ",lacked |
R984 |
T3983 |
T3963 |
cc |
and,lacked |
R985 |
T3742 |
T3740 |
pobj |
role,as |
R986 |
T3984 |
T3985 |
nsubj |
they,displayed |
R987 |
T3985 |
T3963 |
conj |
displayed,lacked |
R988 |
T3986 |
T3987 |
compound |
migration,defects |
R989 |
T3743 |
T3742 |
prep |
for,role |
R990 |
T3987 |
T3985 |
dobj |
defects,displayed |
R991 |
T3988 |
T3987 |
amod |
consistent,defects |
R992 |
T3989 |
T3988 |
prep |
with,consistent |
R993 |
T3744 |
T3745 |
compound |
m,calpain |
R994 |
T3990 |
T3991 |
det |
a,role |
R995 |
T3991 |
T3989 |
pobj |
role,with |
R996 |
T3745 |
T3743 |
pobj |
calpain,for |
R997 |
T3992 |
T3991 |
prep |
for,role |
R998 |
T3993 |
T3992 |
pobj |
calpain,for |
R999 |
T3994 |
T3991 |
prep |
in,role |
R1000 |
T3995 |
T3994 |
pobj |
release,in |
R1001 |
T3996 |
T3995 |
prep |
of,release |
R1002 |
T3997 |
T3998 |
amod |
focal,adhesions |
R1003 |
T4061 |
T4059 |
punct |
", ",mutation |
R1004 |
T3998 |
T3996 |
pobj |
adhesions,of |
R1005 |
T3999 |
T4000 |
punct |
[,9 |
R1006 |
T4000 |
T3985 |
parataxis |
9,displayed |
R1007 |
T4001 |
T4000 |
punct |
],9 |
R1008 |
T4002 |
T3946 |
punct |
.,cultured |
R1009 |
T4062 |
T4063 |
dep |
which,retained |
R1010 |
T4004 |
T4005 |
det |
An,knockout |
R1011 |
T4005 |
T4009 |
nsubj |
knockout,resulted |
R1012 |
T4063 |
T4059 |
relcl |
retained,mutation |
R1013 |
T4006 |
T4007 |
advmod |
independently,derived |
R1014 |
T4007 |
T4005 |
amod |
derived,knockout |
R1015 |
T4008 |
T4005 |
compound |
Capn4,knockout |
R1016 |
T4064 |
T4065 |
det |
some,level |
R1017 |
T4010 |
T4005 |
punct |
", ",knockout |
R1018 |
T4011 |
T4005 |
prep |
involving,knockout |
R1019 |
T4065 |
T4063 |
dobj |
level,retained |
R1020 |
T4012 |
T4013 |
det |
a,deletion |
R1021 |
T4013 |
T4011 |
pobj |
deletion,involving |
R1022 |
T4014 |
T4015 |
advmod |
more,extensive |
R1023 |
T4066 |
T4065 |
amod |
small,level |
R1024 |
T4015 |
T4013 |
amod |
extensive,deletion |
R1025 |
T4016 |
T4013 |
prep |
of,deletion |
R1026 |
T4067 |
T4065 |
prep |
of,level |
R1027 |
T4017 |
T4018 |
det |
the,gene |
R1028 |
T4018 |
T4016 |
pobj |
gene,of |
R1029 |
T4019 |
T4009 |
punct |
", ",resulted |
R1030 |
T4020 |
T4009 |
prep |
in,resulted |
R1031 |
T4068 |
T4069 |
compound |
calpain,activity |
R1032 |
T4021 |
T4022 |
det |
an,lethality |
R1033 |
T4022 |
T4020 |
pobj |
lethality,in |
R1034 |
T4069 |
T4067 |
pobj |
activity,of |
R1035 |
T4023 |
T4022 |
amod |
earlier,lethality |
R1036 |
T4024 |
T4022 |
amod |
embryonic,lethality |
R1037 |
T4025 |
T4009 |
punct |
", ",resulted |
R1038 |
T4070 |
T4044 |
punct |
", ",targeted |
R1039 |
T4026 |
T4027 |
advmod |
apparently,at |
R1040 |
T4027 |
T4009 |
prep |
at,resulted |
R1041 |
T4028 |
T4029 |
det |
a,stage |
R1042 |
T4029 |
T4027 |
pobj |
stage,at |
R1043 |
T4071 |
T4044 |
advcl |
allowing,targeted |
R1044 |
T4030 |
T4029 |
amod |
pre-implantation,stage |
R1045 |
T4031 |
T4032 |
punct |
[,32 |
R1046 |
T4032 |
T4009 |
parataxis |
32,resulted |
R1047 |
T4072 |
T4071 |
prep |
for,allowing |
R1048 |
T4033 |
T4032 |
punct |
],32 |
R1049 |
T4034 |
T4009 |
punct |
.,resulted |
R1050 |
T4073 |
T4074 |
poss |
their,survival |
R1051 |
T4036 |
T4037 |
det |
The,times |
R1052 |
T4037 |
T4039 |
nsubj |
times,suggested |
R1053 |
T4038 |
T4037 |
amod |
different,times |
R1054 |
T4040 |
T4037 |
prep |
of,times |
R1055 |
T4074 |
T4072 |
pobj |
survival,for |
R1056 |
T4041 |
T4042 |
amod |
embryonic,lethality |
R1057 |
T4042 |
T4040 |
pobj |
lethality,of |
R1058 |
T4043 |
T4044 |
mark |
that,targeted |
R1060 |
T4044 |
T4039 |
ccomp |
targeted,suggested |
R1061 |
T4045 |
T4046 |
det |
the,mice |
R1062 |
T4046 |
T4044 |
nsubjpass |
mice,targeted |
R1063 |
T4076 |
T4075 |
pobj |
mid-gestation,to |
R1064 |
T4047 |
T4046 |
amod |
first,mice |
R1065 |
T4048 |
T4046 |
amod |
reported,mice |
R1066 |
T4077 |
T4044 |
punct |
", ",targeted |
R1067 |
T4078 |
T4079 |
mark |
while,represented |
R1068 |
T4079 |
T4044 |
advcl |
represented,targeted |
R1069 |
T4080 |
T4081 |
det |
the,mice |
R1071 |
T4082 |
T4081 |
amod |
second,mice |
R1072 |
T4083 |
T4081 |
amod |
reported,mice |
R1073 |
T4084 |
T4081 |
nmod |
Capn4,mice |
R1074 |
T4085 |
T4084 |
punct |
-,Capn4 |
R1075 |
T4086 |
T4084 |
punct |
/,Capn4 |
R1076 |
T4087 |
T4084 |
punct |
-,Capn4 |
R1077 |
T4088 |
T4089 |
punct |
[,32 |
R1078 |
T4049 |
T4046 |
nmod |
Capn4,mice |
R1079 |
T4089 |
T4081 |
parataxis |
32,mice |
R1080 |
T4090 |
T4089 |
punct |
],32 |
R1081 |
T4050 |
T4049 |
punct |
-,Capn4 |
R1082 |
T4091 |
T4092 |
det |
a,mutation |
R1083 |
T4051 |
T4049 |
punct |
/,Capn4 |
R1084 |
T4052 |
T4049 |
punct |
-,Capn4 |
R1085 |
T4092 |
T4079 |
dobj |
mutation,represented |
R1086 |
T4053 |
T4054 |
punct |
[,31 |
R1087 |
T4054 |
T4046 |
parataxis |
31,mice |
R1088 |
T4093 |
T4092 |
amod |
true,mutation |
R1089 |
T4055 |
T4054 |
punct |
],31 |
R1090 |
T4094 |
T4092 |
amod |
null,mutation |
R1091 |
T4056 |
T4044 |
auxpass |
were,targeted |
R1092 |
T4057 |
T4044 |
prep |
with,targeted |
R1093 |
T4058 |
T4059 |
det |
a,mutation |
R1094 |
T4095 |
T4039 |
punct |
.,suggested |
R1095 |
T4059 |
T4057 |
pobj |
mutation,with |
R1096 |
T4060 |
T4059 |
amod |
hypomorphic,mutation |
R1097 |
T4097 |
T4098 |
nsubjpass |
Disruption,reported |
R1098 |
T4099 |
T4097 |
prep |
of,Disruption |
R1099 |
T4100 |
T4099 |
pobj |
Capn1,of |
R1100 |
T4101 |
T4097 |
punct |
", ",Disruption |
R1101 |
T4102 |
T4097 |
acl |
encoding,Disruption |
R1102 |
T4168 |
T4169 |
det |
The,viability |
R1103 |
T4169 |
T4170 |
nsubj |
viability,distinguish |
R1104 |
T4171 |
T4169 |
prep |
of,viability |
R1105 |
T4172 |
T4173 |
npadvmod |
Capn1,deficient |
R1106 |
T4173 |
T4175 |
amod |
deficient,mice |
R1107 |
T4174 |
T4173 |
punct |
-,deficient |
R1108 |
T4103 |
T4104 |
det |
the,subunit |
R1109 |
T4175 |
T4171 |
pobj |
mice,of |
R1110 |
T4176 |
T4170 |
aux |
does,distinguish |
R1111 |
T4177 |
T4170 |
neg |
not,distinguish |
R1112 |
T4104 |
T4102 |
dobj |
subunit,encoding |
R1113 |
T4178 |
T4170 |
advmod |
however,distinguish |
R1114 |
T4179 |
T4170 |
prep |
between,distinguish |
R1115 |
T4180 |
T4181 |
nummod |
two,possibilities |
R1116 |
T4105 |
T4106 |
nmod |
μ,calpain |
R1117 |
T4181 |
T4179 |
pobj |
possibilities,between |
R1118 |
T4182 |
T4181 |
punct |
: ,possibilities |
R1119 |
T4106 |
T4104 |
nmod |
calpain,subunit |
R1120 |
T4183 |
T4184 |
preconj |
either,required |
R1121 |
T4184 |
T4181 |
advcl |
required,possibilities |
R1122 |
T4185 |
T4184 |
mark |
that,required |
R1123 |
T4107 |
T4106 |
punct |
-,calpain |
R1124 |
T4186 |
T4187 |
compound |
m,calpain |
R1125 |
T4187 |
T4184 |
nsubjpass |
calpain,required |
R1126 |
T4188 |
T4187 |
punct |
-,calpain |
R1127 |
T4108 |
T4104 |
amod |
catalytic,subunit |
R1128 |
T4189 |
T4184 |
auxpass |
is,required |
R1129 |
T4190 |
T4184 |
advmod |
specifically,required |
R1130 |
T4109 |
T4098 |
punct |
", ",reported |
R1131 |
T4191 |
T4184 |
prep |
during,required |
R1132 |
T4192 |
T4191 |
pobj |
embryogenesis,during |
R1133 |
T4193 |
T4184 |
punct |
", ",required |
R1134 |
T4110 |
T4098 |
auxpass |
was,reported |
R1135 |
T4194 |
T4184 |
cc |
or,required |
R1136 |
T4195 |
T4196 |
mark |
that,is |
R1137 |
T4196 |
T4184 |
conj |
is,required |
R1138 |
T4111 |
T4098 |
advmod |
subsequently,reported |
R1139 |
T4197 |
T4198 |
preconj |
either,form |
R1140 |
T4198 |
T4196 |
nsubj |
form,is |
R1141 |
T4199 |
T4198 |
prep |
of,form |
R1142 |
T4112 |
T4113 |
aux |
to,result |
R1143 |
T4200 |
T4199 |
pobj |
calpain,of |
R1144 |
T4201 |
T4198 |
advmod |
alone,form |
R1145 |
T4202 |
T4196 |
acomp |
sufficient,is |
R1146 |
T4113 |
T4098 |
xcomp |
result,reported |
R1147 |
T4203 |
T4196 |
cc |
and,is |
R1148 |
T4204 |
T4205 |
aux |
can,compensate |
R1149 |
T4114 |
T4113 |
prep |
in,result |
R1150 |
T4205 |
T4196 |
conj |
compensate,is |
R1151 |
T4206 |
T4205 |
prep |
for,compensate |
R1152 |
T4207 |
T4208 |
det |
the,absence |
R1153 |
T4115 |
T4116 |
amod |
fertile,mice |
R1154 |
T4208 |
T4206 |
pobj |
absence,for |
R1155 |
T4209 |
T4208 |
prep |
of,absence |
R1156 |
T4210 |
T4211 |
det |
the,other |
R1157 |
T4211 |
T4209 |
pobj |
other,of |
R1158 |
T4212 |
T4170 |
punct |
.,distinguish |
R1159 |
T4116 |
T4114 |
pobj |
mice,in |
R1160 |
T4214 |
T4215 |
aux |
To,resolve |
R1161 |
T4215 |
T4216 |
advcl |
resolve,knocked |
R1162 |
T4117 |
T4116 |
punct |
", ",mice |
R1163 |
T4217 |
T4218 |
det |
this,question |
R1164 |
T4218 |
T4215 |
dobj |
question,resolve |
R1165 |
T4118 |
T4116 |
amod |
viable,mice |
R1166 |
T4219 |
T4216 |
punct |
", ",knocked |
R1167 |
T4220 |
T4216 |
nsubj |
we,knocked |
R1168 |
T4221 |
T4216 |
aux |
have,knocked |
R1169 |
T4119 |
T4116 |
prep |
with,mice |
R1170 |
T4222 |
T4216 |
advmod |
now,knocked |
R1171 |
T4223 |
T4216 |
prt |
out,knocked |
R1172 |
T4224 |
T4225 |
det |
the,gene |
R1173 |
T4120 |
T4121 |
det |
some,defects |
R1174 |
T4225 |
T4216 |
dobj |
gene,knocked |
R1175 |
T4226 |
T4225 |
compound |
Capn2,gene |
R1176 |
T4227 |
T4225 |
acl |
encoding,gene |
R1177 |
T4121 |
T4119 |
pobj |
defects,with |
R1178 |
T4228 |
T4229 |
det |
the,subunit |
R1179 |
T4229 |
T4227 |
dobj |
subunit,encoding |
R1180 |
T4230 |
T4231 |
nmod |
m,k |
R1181 |
T4122 |
T4121 |
amod |
mild,defects |
R1182 |
T4231 |
T4229 |
compound |
k,subunit |
R1183 |
T4232 |
T4231 |
punct |
-,k |
R1184 |
T4233 |
T4231 |
nummod |
80,k |
R1185 |
T4123 |
T4121 |
prep |
in,defects |
R1186 |
T4234 |
T4227 |
prep |
in,encoding |
R1187 |
T4124 |
T4125 |
det |
the,platelets |
R1188 |
T4125 |
T4123 |
pobj |
platelets,in |
R1189 |
T4126 |
T4127 |
compound |
μ,calpain |
R1190 |
T4235 |
T4234 |
pobj |
mice,in |
R1191 |
T4236 |
T4216 |
punct |
.,knocked |
R1192 |
T4127 |
T4129 |
npadvmod |
calpain,rich |
R1193 |
T4238 |
T4239 |
nsubj |
We,report |
R1194 |
T4128 |
T4127 |
punct |
-,calpain |
R1195 |
T4240 |
T4239 |
advmod |
here,report |
R1196 |
T4241 |
T4242 |
mark |
that,died |
R1197 |
T4242 |
T4239 |
ccomp |
died,report |
R1198 |
T4129 |
T4125 |
amod |
rich,platelets |
R1199 |
T4243 |
T4244 |
npadvmod |
Capn2,null |
R1200 |
T4244 |
T4245 |
amod |
null,embryos |
R1201 |
T4130 |
T4121 |
acl |
relating,defects |
R1202 |
T4245 |
T4242 |
nsubj |
embryos,died |
R1203 |
T4246 |
T4247 |
amod |
prior,to |
R1204 |
T4131 |
T4130 |
prep |
to,relating |
R1205 |
T4247 |
T4242 |
prep |
to,died |
R1206 |
T4248 |
T4249 |
det |
the,stage |
R1207 |
T4249 |
T4247 |
pobj |
stage,to |
R1208 |
T4250 |
T4249 |
compound |
implantation,stage |
R1209 |
T4251 |
T4242 |
punct |
", ",died |
R1210 |
T4252 |
T4242 |
advcl |
indicating,died |
R1211 |
T4132 |
T4133 |
poss |
their,aggregation |
R1212 |
T4253 |
T4254 |
mark |
that,is |
R1213 |
T4254 |
T4252 |
ccomp |
is,indicating |
R1214 |
T4255 |
T4256 |
compound |
m,calpain |
R1215 |
T4133 |
T4131 |
pobj |
aggregation,to |
R1216 |
T4256 |
T4254 |
nsubj |
calpain,is |
R1217 |
T4257 |
T4256 |
punct |
-,calpain |
R1218 |
T4258 |
T4254 |
acomp |
indispensable,is |
R1219 |
T4134 |
T4133 |
cc |
and,aggregation |
R1220 |
T4259 |
T4258 |
prep |
for,indispensable |
R1221 |
T4260 |
T4261 |
amod |
early,embryogenesis |
R1222 |
T4261 |
T4259 |
pobj |
embryogenesis,for |
R1223 |
T4135 |
T4136 |
compound |
clot,retraction |
R1224 |
T4262 |
T4239 |
punct |
.,report |
R1225 |
T4264 |
T4265 |
det |
This,role |
R1226 |
T4136 |
T4133 |
conj |
retraction,aggregation |
R1227 |
T4265 |
T4266 |
nsubjpass |
role,fulfilled |
R1228 |
T4267 |
T4266 |
aux |
can,fulfilled |
R1229 |
T4137 |
T4138 |
punct |
[,33 |
R1230 |
T4268 |
T4266 |
neg |
not,fulfilled |
R1231 |
T4269 |
T4266 |
auxpass |
be,fulfilled |
R1232 |
T4270 |
T4266 |
agent |
by,fulfilled |
R1233 |
T4138 |
T4098 |
parataxis |
33,reported |
R1234 |
T4271 |
T4272 |
compound |
μ,calpain |
R1235 |
T4272 |
T4270 |
pobj |
calpain,by |
R1236 |
T4139 |
T4138 |
punct |
],33 |
R1237 |
T4140 |
T4098 |
punct |
.,reported |
R1238 |
T4142 |
T4143 |
det |
The,fact |
R1239 |
T4273 |
T4272 |
punct |
-,calpain |
R1240 |
T4274 |
T4272 |
punct |
", ",calpain |
R1241 |
T4275 |
T4276 |
dep |
which,expressed |
R1242 |
T4143 |
T4144 |
nsubj |
fact,indicates |
R1243 |
T4276 |
T4272 |
relcl |
expressed,calpain |
R1244 |
T4277 |
T4276 |
auxpass |
is,expressed |
R1245 |
T4278 |
T4276 |
prep |
in,expressed |
R1246 |
T4145 |
T4146 |
mark |
that,die |
R1247 |
T4279 |
T4280 |
amod |
embryonic,stem |
R1248 |
T4280 |
T4281 |
nmod |
stem,cells |
R1249 |
T4281 |
T4278 |
pobj |
cells,in |
R1250 |
T4282 |
T4280 |
punct |
(,stem |
R1251 |
T4146 |
T4143 |
acl |
die,fact |
R1252 |
T4283 |
T4280 |
appos |
ES,stem |
R1253 |
T4284 |
T4281 |
punct |
),cells |
R1254 |
T4285 |
T4286 |
punct |
[,31 |
R1255 |
T4147 |
T4148 |
npadvmod |
Capn4,null |
R1256 |
T4286 |
T4276 |
parataxis |
31,expressed |
R1257 |
T4287 |
T4286 |
punct |
],31 |
R1258 |
T4288 |
T4276 |
cc |
and,expressed |
R1259 |
T4148 |
T4149 |
amod |
null,mice |
R1260 |
T4289 |
T4290 |
auxpass |
is,assumed |
R1261 |
T4290 |
T4276 |
conj |
assumed,expressed |
R1262 |
T4291 |
T4292 |
aux |
to,be |
R1263 |
T4292 |
T4290 |
xcomp |
be,assumed |
R1264 |
T4293 |
T4292 |
acomp |
present,be |
R1265 |
T4294 |
T4293 |
prep |
at,present |
R1266 |
T4149 |
T4146 |
nsubj |
mice,die |
R1270 |
T4150 |
T4146 |
prep |
during,die |
R1271 |
T4298 |
T4297 |
pobj |
gestation,of |
R1272 |
T4299 |
T4266 |
punct |
.,fulfilled |
R1273 |
T4151 |
T4150 |
pobj |
embryogenesis,during |
R1274 |
T4301 |
T4302 |
nsubj |
This,demonstrates |
R1275 |
T4152 |
T4153 |
mark |
that,is |
R1276 |
T4303 |
T4302 |
advmod |
unequivocally,demonstrates |
R1277 |
T4304 |
T4305 |
mark |
that,have |
R1278 |
T4305 |
T4302 |
ccomp |
have,demonstrates |
R1279 |
T4153 |
T4144 |
ccomp |
is,indicates |
R1280 |
T4306 |
T4307 |
compound |
m,calpain |
R1281 |
T4307 |
T4305 |
nsubj |
calpain,have |
R1282 |
T4308 |
T4307 |
punct |
-,calpain |
R1283 |
T4154 |
T4155 |
advmod |
at,one |
R1284 |
T4309 |
T4307 |
cc |
and,calpain |
R1285 |
T4310 |
T4311 |
compound |
μ,calpain |
R1286 |
T4311 |
T4307 |
conj |
calpain,calpain |
R1287 |
T4155 |
T4153 |
nsubj |
one,is |
R1288 |
T4312 |
T4311 |
punct |
-,calpain |
R1289 |
T4313 |
T4314 |
amod |
distinct,roles |
R1290 |
T4314 |
T4305 |
dobj |
roles,have |
R1291 |
T4156 |
T4155 |
advmod |
least,one |
R1292 |
T4315 |
T4314 |
amod |
physiological,roles |
R1293 |
T4316 |
T4305 |
prep |
during,have |
R1294 |
T4317 |
T4318 |
amod |
early,embryogenesis |
R1295 |
T4157 |
T4155 |
prep |
of,one |
R1296 |
T4318 |
T4316 |
pobj |
embryogenesis,during |
R1297 |
T4319 |
T4302 |
punct |
.,demonstrates |
R1298 |
T4158 |
T4159 |
det |
the,calpains |
R1299 |
T4159 |
T4157 |
pobj |
calpains,of |
R1300 |
T4160 |
T4159 |
amod |
ubiquitous,calpains |
R1301 |
T4161 |
T4153 |
acomp |
essential,is |
R1302 |
T4162 |
T4161 |
prep |
for,essential |
R1303 |
T4163 |
T4162 |
pobj |
development,for |
R1304 |
T4164 |
T4163 |
prep |
to,development |
R1305 |
T4165 |
T4164 |
pobj |
term,to |
R1306 |
T4166 |
T4144 |
punct |
.,indicates |
R576 |
T3568 |
T3569 |
amod |
neuronal,growth |
R577 |
T3569 |
T3563 |
conj |
growth,degeneration |
R1059 |
T4075 |
T4074 |
prep |
to,survival |
R1070 |
T4081 |
T4079 |
nsubj |
mice,represented |
R1267 |
T4295 |
T4296 |
det |
this,stage |
R1268 |
T4296 |
T4294 |
pobj |
stage,at |
R1269 |
T4297 |
T4296 |
prep |
of,stage |