PMC:1382200 / 1249-1576 JSONTXT

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mutant embryos were detected at the morula but not at the blastocyts stage.\n\nConclusion\nWe conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-cal"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T568","span":{"begin":15,"end":22},"obj":"UBERON:0000922"},{"id":"T569","span":{"begin":44,"end":50},"obj":"UBERON:0000085"},{"id":"T570","span":{"begin":66,"end":76},"obj":"UBERON:0000358"},{"id":"T571","span":{"begin":142,"end":147},"obj":"PR:000005015"},{"id":"T572","span":{"begin":148,"end":152},"obj":"SO:0000704"},{"id":"T573","span":{"begin":168,"end":180},"obj":"GO:0007566"},{"id":"T574","span":{"begin":181,"end":190},"obj":"UBERON:0000922"},{"id":"T575","span":{"begin":213,"end":219},"obj":"UBERON:0000085"},{"id":"T576","span":{"begin":224,"end":234},"obj":"UBERON:0000358"}],"text":"ntation mutant embryos were detected at the morula but not at the blastocyts stage.\n\nConclusion\nWe conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-cal"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T646","span":{"begin":8,"end":14},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T647","span":{"begin":15,"end":22},"obj":"UBERON:0000922"},{"id":"T648","span":{"begin":44,"end":50},"obj":"UBERON:0000085"},{"id":"T649","span":{"begin":66,"end":76},"obj":"UBERON:0000358"},{"id":"T650","span":{"begin":142,"end":147},"obj":"PR_EXT:000005015"},{"id":"T651","span":{"begin":148,"end":152},"obj":"SO_EXT:0000704"},{"id":"T652","span":{"begin":168,"end":180},"obj":"GO:0007566"},{"id":"T653","span":{"begin":181,"end":190},"obj":"UBERON:0000922"},{"id":"T654","span":{"begin":191,"end":200},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T655","span":{"begin":213,"end":219},"obj":"UBERON:0000085"},{"id":"T656","span":{"begin":224,"end":234},"obj":"UBERON:0000358"},{"id":"T657","span":{"begin":264,"end":273},"obj":"GO_PR_EXT:calpain_1_complex"},{"id":"T658","span":{"begin":278,"end":287},"obj":"GO_PR_EXT:calpain_2_complex"}],"text":"ntation mutant embryos were detected at the morula but not at the blastocyts stage.\n\nConclusion\nWe conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-cal"}