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PMC:1382200 / 0-2867 JSONTXT

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Id Subject Object Predicate Lexical cue
T665 0-1 NN denotes m
T666 2-9 NN denotes Calpain
T667 0-71 sentence denotes m-Calpain is required for preimplantation embryonic development in mice
T668 1-2 HYPH denotes -
T669 13-21 VBN denotes required
T670 10-12 VBZ denotes is
T671 22-25 IN denotes for
T672 26-41 NN denotes preimplantation
T673 52-63 NN denotes development
T674 42-51 JJ denotes embryonic
T675 64-66 IN denotes in
T677 71-72 sentence denotes
T678 82-92 sentence denotes Background
T679 82-92 NN denotes Background
T680 92-250 sentence denotes μ-calpain and m-calpain are ubiquitously expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death.
T681 93-94 NN denotes μ
T682 95-102 NN denotes calpain
T683 94-95 HYPH denotes -
T684 117-120 VBP denotes are
T685 103-106 CC denotes and
T686 107-108 NN denotes m
T687 109-116 NN denotes calpain
T688 108-109 HYPH denotes -
T689 121-133 RB denotes ubiquitously
T690 134-143 VBN denotes expressed
T691 144-153 NNS denotes proteases
T692 154-164 VBN denotes implicated
T693 165-167 IN denotes in
T694 168-176 JJ denotes cellular
T695 177-186 NN denotes migration
T696 186-188 , denotes ,
T697 188-192 NN denotes cell
T698 193-198 NN denotes cycle
T699 199-210 NN denotes progression
T700 210-212 , denotes ,
T701 212-224 JJ denotes degenerative
T702 225-234 NNS denotes processes
T703 235-238 CC denotes and
T704 239-243 NN denotes cell
T705 244-249 NN denotes death
T706 249-250 . denotes .
T707 250-424 sentence denotes These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (μ-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4.
T708 251-256 DT denotes These
T709 271-278 NNS denotes enzymes
T710 257-270 JJ denotes heterodimeric
T711 283-291 VBN denotes composed
T712 279-282 VBP denotes are
T713 292-294 IN denotes of
T714 295-303 JJ denotes distinct
T715 314-322 NNS denotes subunits
T716 304-313 JJ denotes catalytic
T717 322-324 , denotes ,
T718 324-331 VBN denotes encoded
T719 332-334 IN denotes by
T720 335-340 NN denotes Capn1
T721 341-342 -LRB- denotes (
T722 342-343 NN denotes μ
T723 344-351 NN denotes calpain
T724 343-344 HYPH denotes -
T725 351-352 -RRB- denotes )
T726 353-355 CC denotes or
T727 356-361 NN denotes Capn2
T728 362-363 -LRB- denotes (
T729 363-364 NN denotes m
T730 365-372 NN denotes calpain
T731 364-365 HYPH denotes -
T732 372-373 -RRB- denotes )
T733 373-375 , denotes ,
T734 375-378 CC denotes and
T735 379-380 DT denotes a
T736 399-406 NN denotes subunit
T737 381-387 JJ denotes common
T738 388-398 JJ denotes regulatory
T739 407-414 VBN denotes encoded
T740 415-417 IN denotes by
T741 418-423 NN denotes Capn4
T742 423-424 . denotes .
T743 424-645 sentence denotes Disruption of the mouse Capn4 gene abolished both μ-calpain and m-calpain activity, and resulted in embryonic lethality, thereby suggesting essential roles for one or both of these enzymes during mammalian embryogenesis.
T744 425-435 NN denotes Disruption
T745 460-469 VBD denotes abolished
T746 436-438 IN denotes of
T747 439-442 DT denotes the
T748 455-459 NN denotes gene
T749 443-448 NN denotes mouse
T750 449-454 NN denotes Capn4
T751 470-474 CC denotes both
T752 477-484 NN denotes calpain
T753 475-476 NN denotes μ
T754 476-477 HYPH denotes -
T755 499-507 NN denotes activity
T756 485-488 CC denotes and
T757 489-490 NN denotes m
T758 491-498 NN denotes calpain
T759 490-491 HYPH denotes -
T760 507-509 , denotes ,
T761 509-512 CC denotes and
T762 513-521 VBD denotes resulted
T763 522-524 IN denotes in
T764 525-534 JJ denotes embryonic
T765 535-544 NN denotes lethality
T766 544-546 , denotes ,
T767 546-553 RB denotes thereby
T768 554-564 VBG denotes suggesting
T769 565-574 JJ denotes essential
T770 575-580 NNS denotes roles
T771 581-584 IN denotes for
T772 585-588 CD denotes one
T773 589-591 CC denotes or
T774 592-596 DT denotes both
T775 597-599 IN denotes of
T776 600-605 DT denotes these
T777 606-613 NNS denotes enzymes
T778 614-620 IN denotes during
T779 621-630 JJ denotes mammalian
T780 631-644 NN denotes embryogenesis
T781 644-645 . denotes .
T782 645-853 sentence denotes Disruption of the Capn1 gene produced viable, fertile mice implying that either m-calpain could compensate for the loss of μ-calpain, or that the loss of m-calpain was responsible for death of Capn4-/- mice.
T783 646-656 NN denotes Disruption
T784 675-683 VBD denotes produced
T785 657-659 IN denotes of
T786 660-663 DT denotes the
T787 670-674 NN denotes gene
T788 664-669 NN denotes Capn1
T789 684-690 JJ denotes viable
T790 700-704 NNS denotes mice
T791 690-692 , denotes ,
T792 692-699 JJ denotes fertile
T793 705-713 VBG denotes implying
T794 714-718 IN denotes that
T795 742-752 VB denotes compensate
T796 719-725 DT denotes either
T797 726-727 NN denotes m
T798 728-735 NN denotes calpain
T799 727-728 HYPH denotes -
T800 736-741 MD denotes could
T801 753-756 IN denotes for
T802 757-760 DT denotes the
T803 761-765 NN denotes loss
T804 766-768 IN denotes of
T805 769-770 NN denotes μ
T806 771-778 NN denotes calpain
T807 770-771 HYPH denotes -
T808 778-780 , denotes ,
T809 780-782 CC denotes or
T810 783-787 IN denotes that
T811 810-813 VBD denotes was
T812 788-791 DT denotes the
T813 792-796 NN denotes loss
T814 797-799 IN denotes of
T815 800-801 NN denotes m
T816 802-809 NN denotes calpain
T817 801-802 HYPH denotes -
T818 814-825 JJ denotes responsible
T819 826-829 IN denotes for
T820 830-835 NN denotes death
T821 836-838 IN denotes of
T822 839-844 NN denotes Capn4
T823 848-852 NNS denotes mice
T824 844-845 SYM denotes -
T825 845-846 HYPH denotes /
T826 846-847 SYM denotes -
T827 852-853 . denotes .
T828 853-862 sentence denotes Results
T829 855-862 NNS denotes Results
T830 862-1069 sentence denotes To distinguish between the alternatives described above, we deleted an essential coding region in the mouse Capn2 gene in embryonic stems cells and transmitted this mutant allele through the mouse germline.
T831 863-865 TO denotes To
T832 866-877 VB denotes distinguish
T833 923-930 VBD denotes deleted
T834 878-885 IN denotes between
T835 886-889 DT denotes the
T836 890-902 NNS denotes alternatives
T837 903-912 VBN denotes described
T838 913-918 RB denotes above
T839 918-920 , denotes ,
T840 920-922 PRP denotes we
T841 931-933 DT denotes an
T842 951-957 NN denotes region
T843 934-943 JJ denotes essential
T844 944-950 NN denotes coding
T845 958-960 IN denotes in
T846 961-964 DT denotes the
T847 977-981 NN denotes gene
T848 965-970 NN denotes mouse
T849 971-976 NN denotes Capn2
T850 982-984 IN denotes in
T851 985-994 JJ denotes embryonic
T852 1001-1006 NNS denotes cells
T853 995-1000 VBZ denotes stems
T854 1007-1010 CC denotes and
T855 1011-1022 VBN denotes transmitted
T856 1023-1027 DT denotes this
T857 1035-1041 NN denotes allele
T858 1028-1034 NN denotes mutant
T859 1042-1049 IN denotes through
T860 1050-1053 DT denotes the
T861 1060-1068 NN denotes germline
T862 1054-1059 NN denotes mouse
T863 1068-1069 . denotes .
T864 1069-1175 sentence denotes Breeding of heterozygous animals failed to produce homozygous mutant live offspring or implanted embryos.
T865 1070-1078 NN denotes Breeding
T866 1103-1109 VBD denotes failed
T867 1079-1081 IN denotes of
T868 1082-1094 JJ denotes heterozygous
T869 1095-1102 NNS denotes animals
T870 1110-1112 TO denotes to
T871 1113-1120 VB denotes produce
T872 1121-1131 JJ denotes homozygous
T873 1144-1153 NN denotes offspring
T874 1132-1138 NN denotes mutant
T875 1139-1143 JJ denotes live
T876 1154-1156 CC denotes or
T877 1157-1166 VBN denotes implanted
T878 1167-1174 NNS denotes embryos
T879 1174-1175 . denotes .
T880 1175-1332 sentence denotes A nested PCR genotyping protocol was established, and homozygous preimplantation mutant embryos were detected at the morula but not at the blastocyts stage.
T881 1176-1177 DT denotes A
T882 1200-1208 NN denotes protocol
T883 1178-1184 VBN denotes nested
T884 1185-1188 NN denotes PCR
T885 1189-1199 NN denotes genotyping
T886 1213-1224 VBN denotes established
T887 1209-1212 VBD denotes was
T888 1224-1226 , denotes ,
T889 1226-1229 CC denotes and
T890 1230-1240 JJ denotes homozygous
T891 1264-1271 NNS denotes embryos
T892 1241-1256 NN denotes preimplantation
T893 1257-1263 NN denotes mutant
T894 1277-1285 VBN denotes detected
T895 1272-1276 VBD denotes were
T896 1286-1288 IN denotes at
T897 1289-1292 DT denotes the
T898 1293-1299 NN denotes morula
T899 1300-1303 CC denotes but
T900 1304-1307 RB denotes not
T901 1308-1310 IN denotes at
T902 1311-1314 DT denotes the
T903 1315-1325 NNS denotes blastocyts
T904 1326-1331 NN denotes stage
T905 1331-1332 . denotes .
T906 1332-1344 sentence denotes Conclusion
T907 1334-1344 NN denotes Conclusion
T908 1344-1490 sentence denotes We conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage.
T909 1345-1347 PRP denotes We
T910 1348-1356 VBP denotes conclude
T911 1357-1361 IN denotes that
T912 1402-1409 VBZ denotes results
T913 1362-1372 JJ denotes homozygous
T914 1373-1383 NN denotes disruption
T915 1384-1386 IN denotes of
T916 1387-1390 DT denotes the
T917 1397-1401 NN denotes gene
T918 1391-1396 NN denotes Capn2
T919 1410-1412 IN denotes in
T920 1413-1429 JJ denotes pre-implantation
T921 1440-1449 NN denotes lethality
T922 1430-1439 JJ denotes embryonic
T923 1450-1457 IN denotes between
T924 1458-1461 DT denotes the
T925 1484-1489 NN denotes stage
T926 1462-1468 NN denotes morula
T927 1469-1472 CC denotes and
T928 1473-1483 NN denotes blastocyst
T929 1489-1490 . denotes .
T930 1490-1643 sentence denotes This establishes that μ-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo.
T931 1491-1495 DT denotes This
T932 1496-1507 VBZ denotes establishes
T933 1508-1512 IN denotes that
T934 1537-1541 VBP denotes have
T935 1513-1514 NN denotes μ
T936 1515-1522 NN denotes calpain
T937 1514-1515 HYPH denotes -
T938 1523-1526 CC denotes and
T939 1527-1528 NN denotes m
T940 1529-1536 NN denotes calpain
T941 1528-1529 HYPH denotes -
T942 1542-1550 JJ denotes distinct
T943 1551-1560 NNS denotes functions
T944 1560-1562 , denotes ,
T945 1562-1565 CC denotes and
T946 1566-1570 IN denotes that
T947 1581-1583 VBZ denotes is
T948 1571-1572 NN denotes m
T949 1573-1580 NN denotes calpain
T950 1572-1573 HYPH denotes -
T951 1584-1589 JJ denotes vital
T952 1590-1593 IN denotes for
T953 1594-1605 NN denotes development
T954 1606-1608 IN denotes of
T955 1609-1612 DT denotes the
T956 1636-1642 NN denotes embryo
T957 1613-1628 NN denotes preimplantation
T958 1629-1635 JJ denotes murine
T959 1642-1643 . denotes .
T3244 1656-1659 DT denotes The
T3245 1700-1709 NNS denotes proteases
T3246 1660-1663 CD denotes two
T3247 1664-1674 JJ denotes ubiquitous
T3248 1675-1678 NN denotes Ca2
T3249 1680-1689 JJ denotes dependent
T3250 1678-1679 SYM denotes +
T3251 1679-1680 HYPH denotes -
T3252 1689-1691 , denotes ,
T3253 1691-1699 NN denotes cysteine
T3254 1767-1770 VBP denotes are
T3255 1710-1715 VBN denotes known
T3256 1716-1718 IN denotes as
T3257 1719-1720 NN denotes μ
T3258 1721-1728 NN denotes calpain
T3259 1720-1721 HYPH denotes -
T3260 1729-1730 -LRB- denotes (
T3261 1730-1737 NN denotes calpain
T3262 1737-1738 HYPH denotes -
T3263 1738-1739 CD denotes 1
T3264 1739-1740 -RRB- denotes )
T3265 1741-1744 CC denotes and
T3266 1745-1746 NN denotes m
T3267 1747-1754 NN denotes calpain
T3268 1746-1747 HYPH denotes -
T3269 1755-1756 -LRB- denotes (
T3270 1756-1762 NN denotes capain
T3271 1762-1763 HYPH denotes -
T3272 1763-1764 CD denotes 2
T3273 1764-1765 -RRB- denotes )
T3274 1765-1767 , denotes ,
T3275 1771-1774 DT denotes the
T3276 1784-1791 NNS denotes members
T3277 1775-1783 NN denotes founding
T3278 1792-1794 IN denotes of
T3279 1795-1796 DT denotes a
T3280 1802-1808 NN denotes family
T3281 1797-1801 NN denotes gene
T3282 1809-1819 VBG denotes comprising
T3283 1820-1822 CD denotes 13
T3284 1823-1828 NNS denotes genes
T3285 1829-1831 IN denotes in
T3286 1832-1839 NNS denotes mammals
T3287 1840-1841 -LRB- denotes [
T3288 1841-1842 CD denotes 1
T3289 1842-1843 SYM denotes -
T3290 1843-1844 CD denotes 3
T3291 1844-1845 -RRB- denotes ]
T3292 1845-1846 . denotes .
T3293 1846-2079 sentence denotes Both are heterodimeric enzymes consisting of distinct 80 kDa catalytic subunits, encoded by the Capn1 (μ-80 k) and Capn2 (m-80 k) genes, respectively, that associate with a common 28 kDa regulatory subunit encoded by the Capn4 gene.
T3294 1847-1851 DT denotes Both
T3295 1852-1855 VBP denotes are
T3296 1856-1869 JJ denotes heterodimeric
T3297 1870-1877 NNS denotes enzymes
T3298 1878-1888 VBG denotes consisting
T3299 1889-1891 IN denotes of
T3300 1892-1900 JJ denotes distinct
T3301 1918-1926 NNS denotes subunits
T3302 1901-1903 CD denotes 80
T3303 1904-1907 NN denotes kDa
T3304 1908-1917 JJ denotes catalytic
T3305 1926-1928 , denotes ,
T3306 1928-1935 VBN denotes encoded
T3307 1936-1938 IN denotes by
T3308 1939-1942 DT denotes the
T3309 1977-1982 NNS denotes genes
T3310 1943-1948 NN denotes Capn1
T3311 1949-1950 -LRB- denotes (
T3312 1955-1956 NN denotes k
T3313 1950-1951 NN denotes μ
T3314 1951-1952 HYPH denotes -
T3315 1952-1954 CD denotes 80
T3316 1956-1957 -RRB- denotes )
T3317 1958-1961 CC denotes and
T3318 1962-1967 NN denotes Capn2
T3319 1968-1969 -LRB- denotes (
T3320 1974-1975 NN denotes k
T3321 1969-1970 NN denotes m
T3322 1970-1971 HYPH denotes -
T3323 1971-1973 CD denotes 80
T3324 1975-1976 -RRB- denotes )
T3325 1982-1984 , denotes ,
T3326 1984-1996 RB denotes respectively
T3327 1996-1998 , denotes ,
T3328 1998-2002 WDT denotes that
T3329 2003-2012 VBP denotes associate
T3330 2013-2017 IN denotes with
T3331 2018-2019 DT denotes a
T3332 2045-2052 NN denotes subunit
T3333 2020-2026 JJ denotes common
T3334 2027-2029 CD denotes 28
T3335 2030-2033 NN denotes kDa
T3336 2034-2044 JJ denotes regulatory
T3337 2053-2060 VBN denotes encoded
T3338 2061-2063 IN denotes by
T3339 2064-2067 DT denotes the
T3340 2074-2078 NN denotes gene
T3341 2068-2073 NN denotes Capn4
T3342 2078-2079 . denotes .
T3343 2079-2249 sentence denotes The μ-80 k and m-80 k subunits share 62% amino acid sequence identity, and are very similar in terms of structure, protein chemistry, and in vitro substrate specificity.
T3344 2080-2083 DT denotes The
T3345 2102-2110 NNS denotes subunits
T3346 2084-2085 NN denotes μ
T3347 2089-2090 NN denotes k
T3348 2085-2086 HYPH denotes -
T3349 2086-2088 CD denotes 80
T3350 2091-2094 CC denotes and
T3351 2095-2096 NN denotes m
T3352 2100-2101 NN denotes k
T3353 2096-2097 HYPH denotes -
T3354 2097-2099 CD denotes 80
T3355 2111-2116 VBP denotes share
T3356 2117-2119 CD denotes 62
T3357 2119-2120 NN denotes %
T3358 2141-2149 NN denotes identity
T3359 2121-2126 NN denotes amino
T3360 2127-2131 NN denotes acid
T3361 2132-2140 NN denotes sequence
T3362 2149-2151 , denotes ,
T3363 2151-2154 CC denotes and
T3364 2155-2158 VBP denotes are
T3365 2159-2163 RB denotes very
T3366 2164-2171 JJ denotes similar
T3367 2172-2174 IN denotes in
T3368 2175-2180 NNS denotes terms
T3369 2181-2183 IN denotes of
T3370 2184-2193 NN denotes structure
T3371 2193-2195 , denotes ,
T3372 2195-2202 NN denotes protein
T3373 2203-2212 NN denotes chemistry
T3374 2212-2214 , denotes ,
T3375 2214-2217 CC denotes and
T3376 2218-2220 FW denotes in
T3377 2221-2226 FW denotes vitro
T3378 2237-2248 NN denotes specificity
T3379 2227-2236 NN denotes substrate
T3380 2248-2249 . denotes .
T3381 2249-2419 sentence denotes Despite these similarities, the differential expression patterns of μ- and m-calpain in mammalian tissues suggest they have some isoform specific and distinct functions.
T3382 2250-2257 IN denotes Despite
T3383 2356-2363 VBP denotes suggest
T3384 2258-2263 DT denotes these
T3385 2264-2276 NNS denotes similarities
T3386 2276-2278 , denotes ,
T3387 2278-2281 DT denotes the
T3388 2306-2314 NNS denotes patterns
T3389 2282-2294 JJ denotes differential
T3390 2295-2305 NN denotes expression
T3391 2315-2317 IN denotes of
T3392 2318-2319 NN denotes μ
T3393 2327-2334 NN denotes calpain
T3394 2319-2320 HYPH denotes -
T3395 2321-2324 CC denotes and
T3396 2325-2326 NN denotes m
T3397 2326-2327 HYPH denotes -
T3398 2335-2337 IN denotes in
T3399 2338-2347 JJ denotes mammalian
T3400 2348-2355 NNS denotes tissues
T3401 2364-2368 PRP denotes they
T3402 2369-2373 VBP denotes have
T3403 2374-2378 DT denotes some
T3404 2409-2418 NNS denotes functions
T3405 2379-2386 NN denotes isoform
T3406 2387-2395 JJ denotes specific
T3407 2396-2399 CC denotes and
T3408 2400-2408 JJ denotes distinct
T3409 2418-2419 . denotes .
T3410 2419-2581 sentence denotes The μ and m designations derive from the levels of Ca2+ required in vitro for optimal activation; 10–50 μM Ca2+ for μ-calpain and 0.3–0.35 mM Ca2+ for m-calpain.
T3411 2420-2423 DT denotes The
T3412 2432-2444 NNS denotes designations
T3413 2424-2425 NN denotes μ
T3414 2426-2429 CC denotes and
T3415 2430-2431 NN denotes m
T3416 2445-2451 VBP denotes derive
T3417 2452-2456 IN denotes from
T3418 2457-2460 DT denotes the
T3419 2461-2467 NNS denotes levels
T3420 2468-2470 IN denotes of
T3421 2471-2474 NN denotes Ca2
T3422 2474-2475 SYM denotes +
T3423 2476-2484 VBN denotes required
T3424 2485-2487 FW denotes in
T3425 2488-2493 FW denotes vitro
T3426 2494-2497 IN denotes for
T3427 2498-2505 JJ denotes optimal
T3428 2506-2516 NN denotes activation
T3429 2516-2517 : denotes ;
T3430 2518-2520 CD denotes 10
T3431 2521-2523 CD denotes 50
T3432 2520-2521 SYM denotes –
T3433 2524-2526 NN denotes μM
T3434 2527-2530 NN denotes Ca2
T3435 2530-2531 SYM denotes +
T3436 2532-2535 IN denotes for
T3437 2536-2537 NN denotes μ
T3438 2538-2545 NN denotes calpain
T3439 2537-2538 HYPH denotes -
T3440 2546-2549 CC denotes and
T3441 2550-2553 CD denotes 0.3
T3442 2554-2558 CD denotes 0.35
T3443 2553-2554 SYM denotes –
T3444 2559-2561 NN denotes mM
T3445 2562-2565 NN denotes Ca2
T3446 2565-2566 SYM denotes +
T3447 2567-2570 IN denotes for
T3448 2571-2572 NN denotes m
T3449 2573-2580 NN denotes calpain
T3450 2572-2573 HYPH denotes -
T3451 2580-2581 . denotes .
T3452 2581-2743 sentence denotes It is generally assumed that μ- and m-calpain maintain their differential sensitivities to calcium in vivo, although this has not yet been strictly demonstrated.
T3453 2582-2584 PRP denotes It
T3454 2598-2605 VBN denotes assumed
T3455 2585-2587 VBZ denotes is
T3456 2588-2597 RB denotes generally
T3457 2606-2610 IN denotes that
T3458 2628-2636 VBP denotes maintain
T3459 2611-2612 NN denotes μ
T3460 2620-2627 NN denotes calpain
T3461 2612-2613 HYPH denotes -
T3462 2614-2617 CC denotes and
T3463 2618-2619 NN denotes m
T3464 2619-2620 HYPH denotes -
T3465 2637-2642 PRP$ denotes their
T3466 2656-2669 NNS denotes sensitivities
T3467 2643-2655 JJ denotes differential
T3468 2670-2672 IN denotes to
T3469 2673-2680 NN denotes calcium
T3470 2681-2683 FW denotes in
T3471 2684-2688 FW denotes vivo
T3472 2688-2690 , denotes ,
T3473 2690-2698 IN denotes although
T3474 2730-2742 VBN denotes demonstrated
T3475 2699-2703 DT denotes this
T3476 2704-2707 VBZ denotes has
T3477 2708-2711 RB denotes not
T3478 2712-2715 RB denotes yet
T3479 2716-2720 VBN denotes been
T3480 2721-2729 RB denotes strictly
T3481 2742-2743 . denotes .
T3483 2744-2755 RB denotes Furthermore
T3484 2843-2850 VBN denotes assumed
T3485 2755-2757 , denotes ,
T3486 2757-2762 IN denotes since
T3487 2803-2805 VBZ denotes is
T3488 2763-2766 DT denotes the
T3489 2789-2802 NN denotes concentration
T3490 2767-2778 JJ denotes cytoplasmic
T3491 2779-2783 JJ denotes free
T3492 2784-2787 NN denotes Ca2
T3493 2787-2788 SYM denotes +
T3494 2806-2815 RB denotes typically
T3495 2816-2820 JJR denotes less
T3496 2826-2827 CD denotes 1
T3497 2821-2825 IN denotes than
T3498 2828-2830 NN denotes μM
T3499 2830-2832 , denotes ,
T3500 2832-2834 PRP denotes it
T3501 2835-2837 VBZ denotes is
T3502 2838-2842 RB denotes also
T3503 2851-2855 IN denotes that
T3505 2856-2861 JJ denotes other
T3507 2862-2864 FW denotes in
T676 67-71 NNS denotes mice
R73 T747 T748 det the,gene
R74 T748 T746 pobj gene,of
R3 T665 T666 compound m,Calpain
R4 T666 T669 nsubjpass Calpain,required
R5 T668 T666 punct -,Calpain
R6 T670 T669 auxpass is,required
R7 T671 T669 prep for,required
R8 T672 T673 nmod preimplantation,development
R9 T673 T671 pobj development,for
R10 T674 T673 amod embryonic,development
R11 T675 T669 prep in,required
R12 T681 T682 compound μ,calpain
R14 T683 T682 punct -,calpain
R15 T685 T682 cc and,calpain
R16 T686 T687 compound m,calpain
R18 T688 T687 punct -,calpain
R19 T689 T690 advmod ubiquitously,expressed
R20 T690 T691 amod expressed,proteases
R21 T691 T684 attr proteases,are
R22 T692 T691 acl implicated,proteases
R23 T693 T692 prep in,implicated
R24 T694 T695 amod cellular,migration
R25 T695 T693 pobj migration,in
R26 T696 T695 punct ", ",migration
R27 T697 T698 compound cell,cycle
R28 T698 T699 compound cycle,progression
R29 T699 T695 conj progression,migration
R30 T700 T699 punct ", ",progression
R31 T701 T702 amod degenerative,processes
R32 T702 T699 conj processes,progression
R33 T703 T702 cc and,processes
R34 T704 T705 compound cell,death
R35 T705 T702 conj death,processes
R36 T706 T684 punct .,are
R37 T708 T709 det These,enzymes
R39 T710 T709 amod heterodimeric,enzymes
R40 T712 T711 auxpass are,composed
R41 T713 T711 prep of,composed
R42 T714 T715 amod distinct,subunits
R44 T716 T715 amod catalytic,subunits
R45 T717 T715 punct ", ",subunits
R46 T718 T715 acl encoded,subunits
R47 T719 T718 agent by,encoded
R48 T720 T719 pobj Capn1,by
R49 T721 T720 punct (,Capn1
R50 T722 T723 compound μ,calpain
R52 T724 T723 punct -,calpain
R53 T725 T720 punct ),Capn1
R54 T726 T720 cc or,Capn1
R55 T727 T720 conj Capn2,Capn1
R56 T728 T727 punct (,Capn2
R57 T729 T730 compound m,calpain
R59 T731 T730 punct -,calpain
R60 T732 T715 punct ),subunits
R61 T733 T715 punct ", ",subunits
R62 T734 T715 cc and,subunits
R63 T735 T736 det a,subunit
R64 T736 T715 conj subunit,subunits
R65 T737 T736 amod common,subunit
R66 T738 T736 amod regulatory,subunit
R67 T739 T736 acl encoded,subunit
R68 T740 T739 agent by,encoded
R69 T741 T740 pobj Capn4,by
R70 T742 T711 punct .,composed
R71 T744 T745 nsubj Disruption,abolished
R72 T746 T744 prep of,Disruption
R75 T749 T748 compound mouse,gene
R76 T750 T748 compound Capn4,gene
R77 T751 T752 preconj both,calpain
R78 T752 T755 nmod calpain,activity
R79 T753 T752 nmod μ,calpain
R80 T754 T752 punct -,calpain
R81 T755 T745 dobj activity,abolished
R82 T756 T752 cc and,calpain
R83 T757 T758 compound m,calpain
R84 T758 T752 conj calpain,calpain
R85 T759 T758 punct -,calpain
R86 T760 T745 punct ", ",abolished
R87 T761 T745 cc and,abolished
R88 T762 T745 conj resulted,abolished
R89 T763 T762 prep in,resulted
R90 T764 T765 amod embryonic,lethality
R91 T765 T763 pobj lethality,in
R92 T766 T762 punct ", ",resulted
R93 T767 T768 advmod thereby,suggesting
R94 T768 T762 advcl suggesting,resulted
R95 T769 T770 amod essential,roles
R96 T770 T768 dobj roles,suggesting
R97 T771 T770 prep for,roles
R98 T772 T771 pobj one,for
R99 T773 T772 cc or,one
R100 T774 T772 conj both,one
R101 T775 T772 prep of,one
R102 T776 T777 det these,enzymes
R103 T777 T775 pobj enzymes,of
R104 T778 T770 prep during,roles
R105 T779 T780 amod mammalian,embryogenesis
R106 T780 T778 pobj embryogenesis,during
R107 T781 T745 punct .,abolished
R108 T783 T784 nsubj Disruption,produced
R109 T785 T783 prep of,Disruption
R110 T786 T787 det the,gene
R112 T788 T787 compound Capn1,gene
R113 T789 T790 amod viable,mice
R114 T790 T784 dobj mice,produced
R115 T791 T790 punct ", ",mice
R116 T792 T790 amod fertile,mice
R117 T793 T784 advcl implying,produced
R118 T794 T795 mark that,compensate
R119 T795 T793 advcl compensate,implying
R120 T796 T795 mark either,compensate
R121 T797 T798 compound m,calpain
R122 T798 T795 nsubj calpain,compensate
R123 T799 T798 punct -,calpain
R124 T800 T795 aux could,compensate
R125 T801 T795 prep for,compensate
R126 T802 T803 det the,loss
R127 T803 T801 pobj loss,for
R128 T804 T803 prep of,loss
R129 T805 T806 compound μ,calpain
R131 T807 T806 punct -,calpain
R132 T808 T795 punct ", ",compensate
R133 T809 T795 cc or,compensate
R134 T810 T811 mark that,was
R135 T811 T795 conj was,compensate
R136 T812 T813 det the,loss
R137 T813 T811 nsubj loss,was
R138 T814 T813 prep of,loss
R139 T815 T816 compound m,calpain
R140 T816 T814 pobj calpain,of
R141 T817 T816 punct -,calpain
R142 T818 T811 acomp responsible,was
R143 T819 T818 prep for,responsible
R144 T820 T819 pobj death,for
R145 T821 T820 prep of,death
R146 T822 T823 nmod Capn4,mice
R147 T823 T821 pobj mice,of
R148 T824 T822 punct -,Capn4
R149 T825 T822 punct /,Capn4
R150 T826 T822 punct -,Capn4
R151 T827 T784 punct .,produced
R152 T831 T832 aux To,distinguish
R153 T832 T833 advcl distinguish,deleted
R154 T834 T832 prep between,distinguish
R155 T835 T836 det the,alternatives
R156 T836 T834 pobj alternatives,between
R157 T837 T836 acl described,alternatives
R158 T838 T837 advmod above,described
R159 T839 T833 punct ", ",deleted
R160 T840 T833 nsubj we,deleted
R161 T841 T842 det an,region
R162 T842 T833 dobj region,deleted
R163 T843 T842 amod essential,region
R164 T844 T842 compound coding,region
R165 T845 T842 prep in,region
R166 T846 T847 det the,gene
R167 T847 T845 pobj gene,in
R168 T848 T847 compound mouse,gene
R169 T849 T847 compound Capn2,gene
R170 T850 T833 prep in,deleted
R171 T851 T852 amod embryonic,cells
R173 T853 T852 nmod stems,cells
R174 T854 T833 cc and,deleted
R175 T855 T833 conj transmitted,deleted
R176 T856 T857 det this,allele
R178 T858 T857 compound mutant,allele
R179 T859 T855 prep through,transmitted
R180 T860 T861 det the,germline
R182 T862 T861 compound mouse,germline
R183 T863 T833 punct .,deleted
R184 T865 T866 nsubj Breeding,failed
R185 T867 T865 prep of,Breeding
R186 T868 T869 amod heterozygous,animals
R187 T869 T867 pobj animals,of
R188 T870 T871 aux to,produce
R189 T871 T866 xcomp produce,failed
R190 T872 T873 amod homozygous,offspring
R191 T873 T871 dobj offspring,produce
R192 T874 T873 nmod mutant,offspring
R193 T875 T873 amod live,offspring
R194 T876 T873 cc or,offspring
R195 T877 T878 amod implanted,embryos
R196 T878 T873 conj embryos,offspring
R197 T879 T866 punct .,failed
R198 T881 T882 det A,protocol
R199 T882 T886 nsubjpass protocol,established
R200 T883 T882 amod nested,protocol
R201 T884 T882 compound PCR,protocol
R202 T885 T882 compound genotyping,protocol
R203 T887 T886 auxpass was,established
R204 T888 T886 punct ", ",established
R205 T889 T886 cc and,established
R206 T890 T891 amod homozygous,embryos
R207 T891 T894 nsubjpass embryos,detected
R208 T892 T891 compound preimplantation,embryos
R209 T893 T891 compound mutant,embryos
R211 T895 T894 auxpass were,detected
R212 T896 T894 prep at,detected
R213 T897 T898 det the,morula
R214 T898 T896 pobj morula,at
R215 T899 T894 cc but,detected
R216 T900 T894 conj not,detected
R217 T901 T900 prep at,not
R218 T902 T903 det the,blastocyts
R219 T903 T901 pobj blastocyts,at
R220 T904 T900 dobj stage,not
R221 T905 T894 punct .,detected
R222 T909 T910 nsubj We,conclude
R223 T911 T912 mark that,results
R224 T912 T910 ccomp results,conclude
R225 T913 T914 amod homozygous,disruption
R226 T914 T912 nsubj disruption,results
R227 T915 T914 prep of,disruption
R228 T916 T917 det the,gene
R229 T917 T915 pobj gene,of
R230 T918 T917 compound Capn2,gene
R231 T919 T912 prep in,results
R232 T920 T921 amod pre-implantation,lethality
R234 T922 T921 amod embryonic,lethality
R235 T923 T912 prep between,results
R236 T924 T925 det the,stage
R237 T925 T923 pobj stage,between
R238 T926 T925 nmod morula,stage
R239 T927 T926 cc and,morula
R240 T928 T926 conj blastocyst,morula
R241 T929 T910 punct .,conclude
R242 T931 T932 nsubj This,establishes
R243 T933 T934 mark that,have
R244 T934 T932 advcl have,establishes
R245 T935 T936 compound μ,calpain
R246 T936 T934 nsubj calpain,have
R247 T937 T936 punct -,calpain
R248 T938 T936 cc and,calpain
R249 T939 T940 compound m,calpain
R250 T940 T936 conj calpain,calpain
R251 T941 T940 punct -,calpain
R252 T942 T943 amod distinct,functions
R253 T943 T934 dobj functions,have
R254 T944 T934 punct ", ",have
R255 T945 T934 cc and,have
R256 T946 T947 mark that,is
R257 T947 T934 conj is,have
R258 T948 T949 compound m,calpain
R259 T949 T947 nsubj calpain,is
R260 T950 T949 punct -,calpain
R261 T951 T947 acomp vital,is
R262 T952 T951 prep for,vital
R263 T953 T952 pobj development,for
R264 T954 T953 prep of,development
R265 T955 T956 det the,embryo
R266 T956 T954 pobj embryo,of
R267 T957 T956 nmod preimplantation,embryo
R268 T958 T956 amod murine,embryo
R269 T959 T932 punct .,establishes
R270 T676 T675 pobj mice,in
R282 T3323 T3320 nummod 80,k
R287 T3324 T3320 punct ),k
R288 T3325 T3306 punct ", ",encoded
R289 T3326 T3306 advmod respectively,encoded
R290 T3244 T3245 det The,proteases
R291 T3327 T3301 punct ", ",subunits
R292 T3245 T3254 nsubj proteases,are
R293 T3246 T3245 nummod two,proteases
R294 T3328 T3329 dep that,associate
R295 T3247 T3245 amod ubiquitous,proteases
R296 T3248 T3249 npadvmod Ca2,dependent
R297 T3329 T3301 relcl associate,subunits
R298 T3249 T3245 amod dependent,proteases
R299 T3250 T3248 punct +,Ca2
R300 T3251 T3249 punct -,dependent
R301 T3330 T3329 prep with,associate
R302 T3252 T3245 punct ", ",proteases
R303 T3253 T3245 compound cysteine,proteases
R304 T3255 T3245 acl known,proteases
R305 T3331 T3332 det a,subunit
R306 T3256 T3255 prep as,known
R307 T3257 T3258 compound μ,calpain
R308 T3258 T3256 pobj calpain,as
R309 T3332 T3330 pobj subunit,with
R310 T3259 T3258 punct -,calpain
R311 T3260 T3258 punct (,calpain
R312 T3261 T3258 appos calpain,calpain
R313 T3333 T3332 amod common,subunit
R314 T3262 T3261 punct -,calpain
R315 T3263 T3261 nummod 1,calpain
R316 T3264 T3258 punct ),calpain
R317 T3334 T3335 nummod 28,kDa
R318 T3265 T3258 cc and,calpain
R319 T3335 T3332 nmod kDa,subunit
R320 T3266 T3267 compound m,calpain
R321 T3267 T3258 conj calpain,calpain
R322 T3268 T3267 punct -,calpain
R323 T3269 T3267 punct (,calpain
R324 T3270 T3267 appos capain,calpain
R325 T3271 T3270 punct -,capain
R326 T3272 T3270 nummod 2,capain
R327 T3273 T3254 punct ),are
R328 T3274 T3254 punct ", ",are
R329 T3275 T3276 det the,members
R330 T3276 T3254 attr members,are
R331 T3277 T3276 compound founding,members
R332 T3278 T3276 prep of,members
R333 T3336 T3332 amod regulatory,subunit
R334 T3279 T3280 det a,family
R335 T3280 T3278 pobj family,of
R336 T3281 T3280 compound gene,family
R337 T3282 T3280 acl comprising,family
R338 T3337 T3332 acl encoded,subunit
R339 T3283 T3284 nummod 13,genes
R340 T3284 T3282 dobj genes,comprising
R341 T3285 T3282 prep in,comprising
R342 T3338 T3337 agent by,encoded
R343 T3286 T3285 pobj mammals,in
R344 T3287 T3288 punct [,1
R345 T3288 T3254 parataxis 1,are
R346 T3339 T3340 det the,gene
R347 T3289 T3290 punct -,3
R348 T3290 T3288 prep 3,1
R349 T3291 T3288 punct ],1
R350 T3340 T3338 pobj gene,by
R351 T3292 T3254 punct .,are
R352 T3341 T3340 compound Capn4,gene
R353 T3294 T3295 nsubj Both,are
R354 T3296 T3297 amod heterodimeric,enzymes
R355 T3342 T3295 punct .,are
R356 T3297 T3295 attr enzymes,are
R357 T3298 T3297 acl consisting,enzymes
R358 T3299 T3298 prep of,consisting
R359 T3344 T3345 det The,subunits
R360 T3300 T3301 amod distinct,subunits
R361 T3301 T3299 pobj subunits,of
R362 T3302 T3303 nummod 80,kDa
R363 T3303 T3301 nmod kDa,subunits
R364 T3345 T3355 nsubj subunits,share
R365 T3304 T3301 amod catalytic,subunits
R366 T3305 T3301 punct ", ",subunits
R367 T3346 T3347 nmod μ,k
R368 T3347 T3345 nmod k,subunits
R369 T3306 T3301 acl encoded,subunits
R370 T3307 T3306 agent by,encoded
R371 T3348 T3346 punct -,μ
R372 T3308 T3309 det the,genes
R373 T3309 T3307 pobj genes,by
R374 T3310 T3309 nmod Capn1,genes
R375 T3311 T3312 punct (,k
R376 T3349 T3346 nummod 80,μ
R377 T3312 T3310 parataxis k,Capn1
R378 T3313 T3312 nmod μ,k
R379 T3314 T3312 punct -,k
R380 T3315 T3312 nummod 80,k
R381 T3350 T3347 cc and,k
R382 T3316 T3312 punct ),k
R383 T3317 T3310 cc and,Capn1
R384 T3318 T3310 conj Capn2,Capn1
R385 T3351 T3352 nmod m,k
R386 T3319 T3320 punct (,k
R387 T3320 T3318 parataxis k,Capn2
R388 T3321 T3320 nmod m,k
R389 T3352 T3347 conj k,k
R390 T3322 T3320 punct -,k
R391 T3353 T3351 punct -,m
R392 T3354 T3351 nummod 80,m
R393 T3356 T3357 nummod 62,%
R394 T3429 T3419 punct ;,levels
R395 T3357 T3358 compound %,identity
R396 T3430 T3431 quantmod 10,50
R397 T3431 T3433 nummod 50,μM
R398 T3358 T3355 dobj identity,share
R399 T3432 T3431 punct –,50
R400 T3433 T3434 compound μM,Ca2
R401 T3434 T3419 appos Ca2,levels
R402 T3359 T3360 compound amino,acid
R403 T3435 T3434 punct +,Ca2
R404 T3436 T3434 prep for,Ca2
R405 T3437 T3438 compound μ,calpain
R406 T3360 T3358 compound acid,identity
R407 T3438 T3436 pobj calpain,for
R408 T3439 T3438 punct -,calpain
R409 T3440 T3434 cc and,Ca2
R410 T3361 T3358 compound sequence,identity
R411 T3441 T3442 quantmod 0.3,0.35
R412 T3442 T3444 nummod 0.35,mM
R413 T3443 T3442 punct –,0.35
R414 T3362 T3355 punct ", ",share
R415 T3444 T3445 compound mM,Ca2
R416 T3445 T3434 conj Ca2,Ca2
R417 T3363 T3355 cc and,share
R418 T3446 T3445 punct +,Ca2
R419 T3447 T3445 prep for,Ca2
R420 T3448 T3449 compound m,calpain
R421 T3449 T3447 pobj calpain,for
R422 T3364 T3355 conj are,share
R423 T3450 T3449 punct -,calpain
R424 T3451 T3416 punct .,derive
R425 T3453 T3454 nsubjpass It,assumed
R426 T3365 T3366 advmod very,similar
R427 T3455 T3454 auxpass is,assumed
R428 T3456 T3454 advmod generally,assumed
R429 T3457 T3458 mark that,maintain
R430 T3366 T3364 acomp similar,are
R431 T3458 T3454 ccomp maintain,assumed
R432 T3459 T3460 nmod μ,calpain
R433 T3367 T3364 prep in,are
R434 T3460 T3458 nsubj calpain,maintain
R435 T3461 T3459 punct -,μ
R436 T3462 T3459 cc and,μ
R437 T3463 T3459 conj m,μ
R438 T3368 T3367 pobj terms,in
R439 T3464 T3460 punct -,calpain
R440 T3465 T3466 poss their,sensitivities
R441 T3466 T3458 dobj sensitivities,maintain
R442 T3369 T3368 prep of,terms
R443 T3467 T3466 amod differential,sensitivities
R444 T3468 T3466 prep to,sensitivities
R445 T3370 T3369 pobj structure,of
R446 T3469 T3468 pobj calcium,to
R447 T3470 T3471 advmod in,vivo
R448 T3471 T3458 advmod vivo,maintain
R449 T3371 T3370 punct ", ",structure
R450 T3472 T3458 punct ", ",maintain
R451 T3473 T3474 mark although,demonstrated
R452 T3372 T3373 compound protein,chemistry
R453 T3373 T3370 conj chemistry,structure
R454 T3474 T3458 advcl demonstrated,maintain
R455 T3475 T3474 nsubjpass this,demonstrated
R456 T3476 T3474 aux has,demonstrated
R457 T3374 T3373 punct ", ",chemistry
R458 T3477 T3474 neg not,demonstrated
R459 T3478 T3474 advmod yet,demonstrated
R460 T3375 T3373 cc and,chemistry
R461 T3479 T3474 auxpass been,demonstrated
R462 T3480 T3474 advmod strictly,demonstrated
R463 T3481 T3454 punct .,assumed
R464 T3376 T3377 advmod in,vitro
R465 T3483 T3484 advmod Furthermore,assumed
R466 T3377 T3378 amod vitro,specificity
R467 T3485 T3484 punct ", ",assumed
R468 T3486 T3487 mark since,is
R469 T3378 T3373 conj specificity,chemistry
R470 T3487 T3484 advcl is,assumed
R471 T3488 T3489 det the,concentration
R472 T3379 T3378 compound substrate,specificity
R473 T3489 T3487 nsubj concentration,is
R474 T3490 T3491 amod cytoplasmic,free
R475 T3491 T3489 amod free,concentration
R476 T3380 T3355 punct .,share
R477 T3492 T3489 nmod Ca2,concentration
R478 T3493 T3492 punct +,Ca2
R479 T3494 T3487 advmod typically,is
R480 T3495 T3496 amod less,1
R481 T3496 T3498 nummod 1,μM
R482 T3497 T3496 quantmod than,1
R483 T3382 T3383 prep Despite,suggest
R484 T3498 T3487 attr μM,is
R485 T3499 T3484 punct ", ",assumed
R486 T3500 T3484 nsubjpass it,assumed
R487 T3501 T3484 auxpass is,assumed
R488 T3384 T3385 det these,similarities
R489 T3502 T3484 advmod also,assumed
R494 T3385 T3382 pobj similarities,Despite
R499 T3386 T3383 punct ", ",suggest
R502 T3387 T3388 det the,patterns
R506 T3388 T3383 nsubj patterns,suggest
R511 T3389 T3388 amod differential,patterns
R514 T3390 T3388 compound expression,patterns
R518 T3391 T3388 prep of,patterns
R522 T3392 T3393 nmod μ,calpain
R526 T3393 T3391 pobj calpain,of
R529 T3394 T3392 punct -,μ
R531 T3395 T3392 cc and,μ
R536 T3396 T3392 conj m,μ
R540 T3397 T3393 punct -,calpain
R542 T3398 T3388 prep in,patterns
R545 T3399 T3400 amod mammalian,tissues
R549 T3400 T3398 pobj tissues,in
R552 T3401 T3402 nsubj they,have
R556 T3402 T3383 advcl have,suggest
R560 T3403 T3404 det some,functions
R562 T3404 T3402 dobj functions,have
R564 T3405 T3406 npadvmod isoform,specific
R568 T3406 T3404 amod specific,functions
R570 T3407 T3406 cc and,specific
R572 T3408 T3406 conj distinct,specific
R575 T3409 T3383 punct .,suggest
R578 T3411 T3412 det The,designations
R586 T3412 T3416 nsubj designations,derive
R589 T3413 T3412 nmod μ,designations
R593 T3414 T3413 cc and,μ
R597 T3415 T3413 conj m,μ
R601 T3417 T3416 prep from,derive
R606 T3418 T3419 det the,levels
R610 T3419 T3417 pobj levels,from
R615 T3420 T3419 prep of,levels
R618 T3421 T3420 pobj Ca2,of
R622 T3422 T3421 punct +,Ca2
R626 T3423 T3419 acl required,levels
R630 T3424 T3425 advmod in,vitro
R637 T3425 T3423 advmod vitro,required
R640 T3426 T3423 prep for,required
R645 T3427 T3428 amod optimal,activation
R649 T3428 T3426 pobj activation,for
R13 T682 T684 nsubj calpain,are
R17 T687 T682 conj calpain,calpain
R38 T709 T711 nsubjpass enzymes,composed
R43 T715 T713 pobj subunits,of
R51 T723 T720 appos calpain,Capn1
R58 T730 T727 appos calpain,Capn2
R111 T787 T785 pobj gene,of
R130 T806 T804 pobj calpain,of
R172 T852 T850 pobj cells,in
R177 T857 T855 dobj allele,transmitted
R181 T861 T859 pobj germline,through
R210 T894 T886 conj detected,established
R233 T921 T919 pobj lethality,in

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T533 29-41 GO:0007566 denotes implantation
T534 42-51 UBERON:0000922 denotes embryonic
T535 42-63 GO:0009790 denotes embryonic development
T536 67-71 NCBITaxon:10088 denotes mice
T537 134-143 GO:0010467 denotes expressed
T538 168-186 GO:0016477 denotes cellular migration
T539 188-198 GO:0007049 denotes cell cycle
T540 239-249 GO:0008219 denotes cell death
T541 335-340 PR:000005009 denotes Capn1
T542 356-361 PR:000005015 denotes Capn2
T543 388-398 GO:0065007 denotes regulatory
T544 418-423 PR:000005022 denotes Capn4
T545 443-448 NCBITaxon:10088 denotes mouse
T546 449-454 PR:000005022 denotes Capn4
T547 455-459 SO:0000704 denotes gene
T548 525-534 UBERON:0000922 denotes embryonic
T549 621-630 NCBITaxon:40674 denotes mammalian
T550 631-644 GO:0009790 denotes embryogenesis
T551 664-669 PR:000005009 denotes Capn1
T552 670-674 SO:0000704 denotes gene
T553 700-704 NCBITaxon:10088 denotes mice
T554 830-835 GO:0016265 denotes death
T555 839-844 PR:000005022 denotes Capn4
T556 848-852 NCBITaxon:10088 denotes mice
T557 965-970 NCBITaxon:10088 denotes mouse
T558 971-976 PR:000005015 denotes Capn2
T559 977-981 SO:0000704 denotes gene
T560 985-994 UBERON:0000922 denotes embryonic
T561 985-1006 CL:0002322 denotes embryonic stems cells
T562 1035-1041 SO:0001023 denotes allele
T563 1054-1059 NCBITaxon:10088 denotes mouse
T564 1095-1102 NCBITaxon:33208 denotes animals
T565 1157-1166 GO:0007566 denotes implanted
T566 1167-1174 UBERON:0000922 denotes embryos
T567 1244-1256 GO:0007566 denotes implantation
T568 1264-1271 UBERON:0000922 denotes embryos
T569 1293-1299 UBERON:0000085 denotes morula
T570 1315-1325 UBERON:0000358 denotes blastocyts
T571 1391-1396 PR:000005015 denotes Capn2
T572 1397-1401 SO:0000704 denotes gene
T573 1417-1429 GO:0007566 denotes implantation
T574 1430-1439 UBERON:0000922 denotes embryonic
T575 1462-1468 UBERON:0000085 denotes morula
T576 1473-1483 UBERON:0000358 denotes blastocyst
T577 1594-1608 _FRAGMENT denotes development of
T578 1636-1642 GO:0009790 denotes embryo
T579 1616-1628 GO:0007566 denotes implantation
T580 1629-1635 NCBITaxon:39107 denotes murine
T581 1636-1642 UBERON:0000922 denotes embryo
T2933 1797-1801 SO:0000704 denotes gene
T2934 1823-1828 SO:0000704 denotes genes
T2935 1832-1839 NCBITaxon:40674 denotes mammals
T2936 1943-1948 PR:000005009 denotes Capn1
T2937 1950-1956 PR:000005009 denotes μ-80 k
T2938 1962-1967 PR:000005015 denotes Capn2
T2939 1969-1975 PR:000005015 denotes m-80 k
T2940 1977-1982 SO:0000704 denotes genes
T2941 2034-2044 GO:0065007 denotes regulatory
T2942 2068-2073 PR:000005022 denotes Capn4
T2943 2074-2078 SO:0000704 denotes gene
T2944 2084-2090 _FRAGMENT denotes μ-80 k
T2945 2102-2110 PR:000005009 denotes subunits
T2946 2095-2110 PR:000005015 denotes m-80 k subunits
T2947 2295-2305 GO:0010467 denotes expression
T2948 2338-2347 NCBITaxon:40674 denotes mammalian
T2949 2348-2355 UBERON:0000479 denotes tissues
T2950 2379-2386 SO:0001060 denotes isoform
T2951 2471-2475 CHEBI:29108 denotes Ca2+
T2952 2527-2531 CHEBI:29108 denotes Ca2+
T2953 2562-2566 CHEBI:29108 denotes Ca2+
T2954 2767-2778 GO:0005737 denotes cytoplasmic
T2955 2784-2788 CHEBI:29108 denotes Ca2+
T2931 1675-1679 CHEBI:29108 denotes Ca2+
T2932 1756-1764 PR:000005015 denotes capain-2
R271 T2945 T2944 _lexicallyChainedTo subunits,μ-80 k
R1 T578 T577 _lexicallyChainedTo embryo,development of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T582 0-9 GO_PR_EXT:calpain_2_complex denotes m-Calpain
T583 29-41 GO:0007566 denotes implantation
T584 42-51 UBERON:0000922 denotes embryonic
T585 42-63 GO:0009790 denotes embryonic development
T586 67-71 NCBITaxon:10088 denotes mice
T587 93-102 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T588 107-116 GO_PR_EXT:calpain_2_complex denotes m-calpain
T589 134-143 GO:0010467 denotes expressed
T590 144-153 GO_EXT:0008233 denotes proteases
T591 168-176 CL_GO_EXT:cell denotes cellular
T592 168-186 GO:0016477 denotes cellular migration
T593 188-192 CL_GO_EXT:cell denotes cell
T594 188-198 GO:0007049 denotes cell cycle
T595 239-243 CL_GO_EXT:cell denotes cell
T596 239-249 GO:0008219 denotes cell death
T597 263-270 GO_EXT:dimer_macromolecular_complex denotes dimeric
T598 271-278 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T599 304-313 GO_MOP_EXT:catalysis denotes catalytic
T600 324-331 SO_EXT:sequence_coding_function denotes encoded
T601 335-340 PR_EXT:000005009 denotes Capn1
T602 342-351 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T603 356-361 PR_EXT:000005015 denotes Capn2
T604 363-372 GO_PR_EXT:calpain_2_complex denotes m-calpain
T605 388-398 GO:0065007 denotes regulatory
T606 407-414 SO_EXT:sequence_coding_function denotes encoded
T607 418-423 PR_EXT:000005022 denotes Capn4
T608 443-448 NCBITaxon:10088 denotes mouse
T609 449-454 PR_EXT:000005022 denotes Capn4
T610 455-459 SO_EXT:0000704 denotes gene
T611 475-484 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T612 489-498 GO_PR_EXT:calpain_2_complex denotes m-calpain
T613 525-534 UBERON:0000922 denotes embryonic
T614 535-544 GO_EXT:fatality_or_lethality denotes lethality
T615 606-613 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T616 621-630 NCBITaxon:40674 denotes mammalian
T617 631-644 GO:0009790 denotes embryogenesis
T618 664-669 PR_EXT:000005009 denotes Capn1
T619 670-674 SO_EXT:0000704 denotes gene
T620 700-704 NCBITaxon:10088 denotes mice
T621 726-735 GO_PR_EXT:calpain_2_complex denotes m-calpain
T622 769-778 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T623 800-809 GO_PR_EXT:calpain_2_complex denotes m-calpain
T624 830-835 GO:0016265 denotes death
T625 839-844 PR_EXT:000005022 denotes Capn4
T626 844-845 SO_EXT:sequence_nullness_or_absence denotes -
T627 846-847 SO_EXT:sequence_nullness_or_absence denotes -
T628 848-852 NCBITaxon:10088 denotes mice
T629 923-930 SO_EXT:sequence_deletion_process denotes deleted
T630 944-957 SO_EXT:coding_sequence denotes coding region
T631 965-970 NCBITaxon:10088 denotes mouse
T632 971-976 PR_EXT:000005015 denotes Capn2
T633 977-981 SO_EXT:0000704 denotes gene
T634 985-994 UBERON:0000922 denotes embryonic
T635 985-1006 CL:0002322 denotes embryonic stems cells
T636 1001-1006 CL_GO_EXT:cell denotes cells
T637 1028-1034 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T638 1035-1041 SO_EXT:0001023 denotes allele
T639 1054-1059 NCBITaxon:10088 denotes mouse
T640 1070-1078 GO_EXT:breeding denotes Breeding
T641 1095-1102 NCBITaxon:33208 denotes animals
T642 1132-1138 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T643 1157-1166 GO:0007566 denotes implanted
T644 1167-1174 UBERON:0000922 denotes embryos
T645 1244-1256 GO:0007566 denotes implantation
T646 1257-1263 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T647 1264-1271 UBERON:0000922 denotes embryos
T648 1293-1299 UBERON:0000085 denotes morula
T649 1315-1325 UBERON:0000358 denotes blastocyts
T650 1391-1396 PR_EXT:000005015 denotes Capn2
T651 1397-1401 SO_EXT:0000704 denotes gene
T652 1417-1429 GO:0007566 denotes implantation
T653 1430-1439 UBERON:0000922 denotes embryonic
T654 1440-1449 GO_EXT:fatality_or_lethality denotes lethality
T655 1462-1468 UBERON:0000085 denotes morula
T656 1473-1483 UBERON:0000358 denotes blastocyst
T657 1513-1522 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T658 1527-1536 GO_PR_EXT:calpain_2_complex denotes m-calpain
T659 1571-1580 GO_PR_EXT:calpain_2_complex denotes m-calpain
T660 1594-1608 _FRAGMENT denotes development of
T661 1636-1642 GO:0009790 denotes embryo
T662 1616-1628 GO:0007566 denotes implantation
T663 1629-1635 NCBITaxon:39107 denotes murine
T664 1636-1642 UBERON:0000922 denotes embryo
T3038 1691-1699 CHEBI_SO_EXT:cysteine denotes cysteine
T3039 1691-1709 GO_EXT:0008234 denotes cysteine proteases
T3040 1719-1728 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3041 1730-1739 GO_PR_EXT:calpain_1_complex denotes calpain-1
T3042 1745-1754 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3043 1756-1764 PR_EXT:000005015 denotes capain-2
T3044 1756-1764 GO_PR_EXT:calpain_2_complex denotes capain-2
T3045 1797-1801 SO_EXT:0000704 denotes gene
T3046 1823-1828 SO_EXT:0000704 denotes genes
T3047 1832-1839 NCBITaxon:40674 denotes mammals
T3048 1862-1869 GO_EXT:dimer_macromolecular_complex denotes dimeric
T3049 1870-1877 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T3050 1908-1917 GO_MOP_EXT:catalysis denotes catalytic
T3051 1928-1935 SO_EXT:sequence_coding_function denotes encoded
T3052 1943-1948 PR_EXT:000005009 denotes Capn1
T3053 1950-1956 PR_EXT:000005009 denotes μ-80 k
T3054 1962-1967 PR_EXT:000005015 denotes Capn2
T3055 1969-1975 PR_EXT:000005015 denotes m-80 k
T3056 1977-1982 SO_EXT:0000704 denotes genes
T3057 2034-2044 GO:0065007 denotes regulatory
T3058 2053-2060 SO_EXT:sequence_coding_function denotes encoded
T3059 2068-2073 PR_EXT:000005022 denotes Capn4
T3060 2074-2078 SO_EXT:0000704 denotes gene
T3061 2084-2090 _FRAGMENT denotes μ-80 k
T3062 2102-2110 PR_EXT:000005009 denotes subunits
T3063 2095-2110 PR_EXT:000005015 denotes m-80 k subunits
T3064 2121-2131 CHEBI_SO_EXT:amino_acid denotes amino acid
T3065 2132-2140 SO_EXT:biological_sequence denotes sequence
T3066 2195-2202 CHEBI_PR_EXT:protein denotes protein
T3067 2295-2305 GO:0010467 denotes expression
T3068 2318-2320 _FRAGMENT denotes μ-
T3069 2327-2334 GO_PR_EXT:calpain_1_complex denotes calpain
T3070 2325-2334 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3071 2338-2347 NCBITaxon:40674 denotes mammalian
T3072 2348-2355 UBERON:0000479 denotes tissues
T3073 2379-2386 SO_EXT:0001060 denotes isoform
T3074 2471-2475 CHEBI:29108 denotes Ca2+
T3075 2527-2531 CHEBI:29108 denotes Ca2+
T3076 2536-2545 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3077 2562-2566 CHEBI:29108 denotes Ca2+
T3078 2571-2580 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3079 2611-2613 _FRAGMENT denotes μ-
T3080 2620-2627 GO_PR_EXT:calpain_1_complex denotes calpain
T3081 2618-2627 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3082 2673-2680 CHEBI_EXT:calcium denotes calcium
T3083 2767-2778 GO:0005737 denotes cytoplasmic
T3084 2784-2788 CHEBI:29108 denotes Ca2+
T3037 1675-1679 CHEBI:29108 denotes Ca2+
R274 T3062 T3061 _lexicallyChainedTo subunits,μ-80 k
R275 T3069 T3068 _lexicallyChainedTo calpain,μ-
R278 T3080 T3079 _lexicallyChainedTo calpain,μ-
R2 T661 T660 _lexicallyChainedTo embryo,development of