> top > docs > PMC:1359074 > spans > 8456-25538 > annotations

PMC:1359074 / 8456-25538 JSONTXT

Annnotations TAB JSON ListView MergeView

2_test

Id Subject Object Predicate Lexical cue
16462943-11702786-85760988 328-330 11702786 denotes 13
16462943-10760285-85760989 1243-1245 10760285 denotes 14
16462943-1701019-85760990 1697-1699 1701019 denotes 29
16462943-1848707-85760991 2832-2834 1848707 denotes 30
16462943-2748594-85760992 2939-2941 2748594 denotes 31
16462943-12677004-85760993 3308-3310 12677004 denotes 32
16462943-11504872-85760994 4993-4994 11504872 denotes 5
16462943-11504872-85760995 5298-5299 11504872 denotes 5
16462943-11504872-85760996 5801-5802 11504872 denotes 5
16462943-283312-85760997 9863-9865 283312 denotes 33
T32068 328-330 11702786 denotes 13
T50025 1243-1245 10760285 denotes 14
T75422 1697-1699 1701019 denotes 29
T87948 2832-2834 1848707 denotes 30
T97917 2939-2941 2748594 denotes 31
T50696 3308-3310 12677004 denotes 32
T36890 4993-4994 11504872 denotes 5
T88558 5298-5299 11504872 denotes 5
T4443 5801-5802 11504872 denotes 5
T6698 9863-9865 283312 denotes 33

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T7965 11369-11374 NN denotes dimer
T4724 1092-1100 RB denotes somewhat
T10029 14996-15010 NN denotes erythropoiesis
T10028 14985-14995 JJ denotes definitive
T10027 14982-14984 IN denotes in
T10026 14972-14981 NN denotes functions
T10025 14967-14971 NN denotes Sox6
T10024 14962-14966 IN denotes that
T10023 14950-14961 VB denotes demonstrate
T10022 14948-14949 -COMMA- denotes ,
T10021 14947-14948 -RRB- denotes )
T10020 14946-14947 CD denotes 5
T10019 14939-14945 NN denotes Figure
T10018 14938-14939 -LRB- denotes (
T10017 14933-14937 NN denotes mice
T10016 14926-14932 JJ denotes mutant
T10015 14920-14925 NN denotes p100H
T10014 14911-14919 JJ denotes 14.5-dpc
T10013 14908-14910 IN denotes of
T10012 14902-14907 NN denotes cells
T10011 14896-14901 NN denotes liver
T10010 14892-14895 DT denotes the
T10009 14889-14891 IN denotes in
T10008 14879-14888 VB denotes expressed
T10007 14872-14878 RB denotes highly
T10006 14869-14871 VB denotes is
T10005 14862-14868 NN denotes globin
T10004 14859-14861 JJ denotes ɛy
T10003 14854-14858 IN denotes that
T10002 14842-14853 NN denotes observation
T10001 14838-14841 DT denotes the
T10000 14833-14837 IN denotes with
T9999 14824-14832 RB denotes together
T9998 14818-14823 VB denotes taken
T9997 14816-14817 -COMMA- denotes ,
T9996 14812-14816 NN denotes data
T9995 14806-14811 DT denotes These
T10498 16765-16775 NN denotes maturation
T10497 16760-16764 NN denotes cell
T10496 16756-16759 JJ denotes red
T10495 16749-16755 VB denotes affect
T10494 16745-16748 MD denotes may
T10493 16740-16744 NN denotes Sox6
T10492 16738-16739 -COMMA- denotes ,
T10491 16734-16738 NN denotes gene
T10490 16727-16733 NN denotes globin
T10489 16724-16726 JJ denotes ɛy
T10488 16720-16723 DT denotes the
T10487 16710-16719 VB denotes silencing
T10486 16702-16709 IN denotes besides
T10485 16697-16701 IN denotes that
T10484 16689-16696 VB denotes suggest
T10483 16676-16688 NN denotes observations
T10482 16670-16675 DT denotes These
T10481 16665-16668 NN denotes dpc
T10480 16660-16664 CD denotes 14.5
T10479 16657-16659 IN denotes as
T10478 16651-16656 RB denotes early
T10477 16648-16650 RB denotes as
T10476 16642-16647 VB denotes noted
T10475 16639-16641 VB denotes is
T10474 16628-16638 NN denotes alteration
T10473 16623-16627 DT denotes This
T10472 16620-16621 -RRB- denotes )
T10471 16618-16620 NN denotes 7B
T10470 16611-16617 NN denotes Figure
T10469 16610-16611 -LRB- denotes (
T10468 16606-16609 NN denotes dpc
T10467 16601-16605 CD denotes 18.5
T10466 16598-16600 IN denotes at
T10465 16585-16597 NN denotes erythrocytes
T10464 16575-16584 JJ denotes nucleated
T10463 16565-16574 VB denotes including
T10462 16559-16564 NN denotes cells
T10461 16549-16558 NN denotes precursor
T10460 16535-16548 JJ denotes hematopoietic
T10459 16532-16534 IN denotes in
T10458 16523-16531 NN denotes increase
T10457 16511-16522 JJ denotes significant
T10456 16509-16510 DT denotes a
T10455 16503-16508 VB denotes shows
T10454 16497-16502 NN denotes liver
T10453 16490-16496 JJ denotes mutant
T10452 16486-16489 DT denotes the
T10451 16484-16485 -COMMA- denotes ,
T10450 16476-16484 NN denotes addition
T10449 16473-16475 IN denotes In
T10448 16465-16471 NN denotes effect
T10447 16455-16464 JJ denotes transient
T10446 16453-16454 DT denotes a
T10445 16450-16452 VB denotes be
T10444 16446-16449 MD denotes may
T10443 16441-16445 DT denotes this
T10442 16436-16440 IN denotes that
T10441 16425-16435 VB denotes suggesting
T10440 16423-16424 -COMMA- denotes ,
T10439 16419-16423 NN denotes mice
T10438 16412-16418 JJ denotes mutant
T10437 16409-16411 CC denotes or
T10436 16406-16408 NN denotes WT
T10435 16399-16405 CC denotes either
T10434 16396-16398 IN denotes in
T10433 16390-16395 NN denotes cells
T10432 16386-16389 JJ denotes red
T10431 16376-16385 JJ denotes nucleated
T10430 16364-16375 VB denotes circulating
T10429 16360-16363 VB denotes see
T10428 16356-16359 RB denotes not
T10427 16353-16355 VB denotes do
T10426 16350-16352 PRP denotes we
T10425 16348-16349 -COMMA- denotes ,
T10424 16344-16348 CD denotes 10.5
T10423 16340-16343 NN denotes day
T10422 16330-16339 JJ denotes postnatal
T10421 16327-16329 IN denotes at
T10420 16325-16326 -COMMA- denotes ,
T10419 16318-16325 RB denotes However
T10418 16315-16316 -RRB- denotes )
T10417 16313-16315 NN denotes 7A
T10416 16306-16312 NN denotes Figure
T10415 16305-16306 -LRB- denotes (
T10414 16301-16304 NN denotes dpc
T10413 16296-16300 CD denotes 18.5
T10412 16292-16295 CC denotes and
T10411 16288-16291 NN denotes dpc
T10410 16283-16287 CD denotes 14.5
T10409 16280-16282 IN denotes at
T10408 16275-16279 NN denotes mice
T10407 16272-16274 JJ denotes WT
T10406 16269-16271 IN denotes in
T10405 16264-16268 IN denotes than
T10404 16259-16263 NN denotes mice
T10403 16252-16258 JJ denotes mutant
T10402 16246-16251 NN denotes p100H
T10401 16243-16245 IN denotes in
T10400 16231-16242 VB denotes circulating
T10399 16225-16230 NN denotes cells
T10398 16219-16224 NN denotes blood
T10397 16215-16218 JJ denotes red
T10396 16205-16214 JJ denotes nucleated
T10395 16200-16204 RB denotes more
T10394 16196-16199 VB denotes are
T10393 16190-16195 EX denotes there
T10392 16185-16189 IN denotes that
T10391 16177-16184 VB denotes noticed
T10390 16172-16176 VB denotes have
T10389 16169-16171 PRP denotes we
T10388 16167-16168 -COMMA- denotes ,
T10387 16153-16167 NN denotes erythropoiesis
T10386 16150-16152 IN denotes in
T10385 16142-16149 NN denotes effects
T10384 16137-16141 NN denotes Sox6
T10383 16131-16136 JJ denotes other
T10382 16127-16130 DT denotes the
T10381 16121-16126 IN denotes Among
T10380 16115-16120 NNP denotes Cells
T10379 16111-16114 NNP denotes Red
T10378 16101-16110 NNP denotes Nucleated
T10377 16098-16100 IN denotes of
T10376 16090-16097 NNP denotes Numbers
T10375 16083-16089 NNP denotes Higher
T10374 16078-16082 NNP denotes Have
T10373 16073-16077 NNP denotes Mice
T10372 16067-16072 NN denotes p100H
T10371 16060-16066 JJ denotes Mutant
T9994 14790-14804 NN denotes erythropoiesis
T9993 14788-14789 -COMMA- denotes ,
T9992 14779-14788 JJ denotes primitive
T9991 14775-14778 RB denotes not
T9990 14771-14774 CC denotes but
T9989 14769-14770 -COMMA- denotes ,
T9988 14759-14769 JJ denotes definitive
T9987 14754-14758 IN denotes with
T9986 14743-14753 JJ denotes coincident
T9985 14733-14742 RB denotes spatially
T9984 14729-14732 CC denotes and
T9983 14718-14728 RB denotes temporally
T9982 14715-14717 VB denotes is
T9981 14704-14714 NN denotes expression
T9980 14699-14703 NN denotes Sox6
T9979 14697-14698 -COMMA- denotes ,
T9978 14688-14697 RB denotes Therefore
T9977 14685-14686 -RRB- denotes )
T9976 14683-14685 NN denotes 6B
T9975 14676-14682 NN denotes Figure
T9974 14675-14676 -LRB- denotes (
T9973 14671-14674 NN denotes dpc
T9972 14667-14670 CD denotes 7.5
T9971 14664-14666 IN denotes at
T9970 14656-14663 NN denotes islands
T9969 14650-14655 NN denotes blood
T9968 14646-14649 NN denotes sac
T9967 14641-14645 NN denotes yolk
T9966 14638-14640 IN denotes in
T9965 14634-14637 RB denotes not
T9964 14630-14633 CC denotes but
T9963 14628-14629 -COMMA- denotes ,
T9962 14623-14628 NN denotes liver
T9961 14614-14622 NN denotes 12.5-dpc
T9960 14611-14613 IN denotes in
T9959 14599-14610 VB denotes transcribed
T9958 14592-14598 RB denotes highly
T9957 14589-14591 VB denotes is
T9956 14584-14588 NN denotes Sox6
T9955 14579-14583 IN denotes that
T9954 14573-14578 VB denotes shows
T9953 14559-14572 NN denotes hybridization
T9952 14554-14558 FW denotes situ
T9951 14551-14553 FW denotes in
T9950 14549-14550 -COMMA- denotes ,
T9949 14538-14549 RB denotes Furthermore
T9948 14531-14536 NN denotes liver
T9947 14527-14530 DT denotes the
T9946 14524-14526 IN denotes in
T9945 14509-14523 NN denotes erythropoiesis
T9944 14498-14508 JJ denotes definitive
T9943 14495-14497 IN denotes of
T9942 14489-14494 NN denotes onset
T9941 14480-14488 JJ denotes temporal
T9940 14476-14479 DT denotes the
T9939 14471-14475 IN denotes with
T9938 14460-14470 JJ denotes coincident
T9937 14458-14459 -COMMA- denotes ,
T9936 14455-14458 NN denotes dpc
T9935 14450-14454 CD denotes 10.5
T9934 14447-14449 IN denotes at
T9933 14437-14446 VB denotes beginning
T9932 14432-14436 NN denotes blot
T9931 14423-14431 JJ denotes Northern
T9930 14420-14422 IN denotes by
T9929 14409-14419 JJ denotes detectable
T9928 14406-14408 VB denotes is
T9927 14401-14405 NN denotes Sox6
T9926 14399-14400 -COMMA- denotes ,
T9925 14397-14399 NN denotes 6A
T9924 14390-14396 NN denotes Figure
T9923 14387-14389 IN denotes in
T9922 14381-14386 VB denotes shown
T9921 14378-14380 IN denotes As
T9920 14368-14376 VB denotes employed
T9919 14363-14367 VB denotes were
T9918 14356-14362 NN denotes assays
T9917 14342-14355 NN denotes hybridization
T9916 14337-14341 FW denotes situ
T9915 14334-14336 FW denotes in
T9914 14330-14333 CC denotes and
T9913 14325-14329 NN denotes blot
T9912 14316-14324 NN denotes Northern
T9911 14314-14315 -COMMA- denotes ,
T9910 14310-14314 NN denotes Sox6
T9909 14307-14309 IN denotes of
T9908 14299-14306 NN denotes pattern
T9907 14288-14298 NN denotes expression
T9906 14280-14287 JJ denotes spatial
T9905 14276-14279 CC denotes and
T9904 14267-14275 JJ denotes temporal
T9903 14263-14266 DT denotes the
T9902 14253-14262 VB denotes determine
T9901 14250-14252 TO denotes To
T9900 14234-14248 NN denotes erythropoiesis
T9899 14223-14233 JJ denotes definitive
T9898 14220-14222 IN denotes in
T9897 14210-14219 NN denotes regulator
T9896 14200-14209 JJ denotes important
T9895 14197-14199 DT denotes an
T9894 14194-14196 VB denotes is
T9878 14094-14105 RB denotes ectopically
T9877 14089-14093 NN denotes mice
T9876 14074-14088 JJ denotes Sox6-deficient
T9875 14069-14073 IN denotes that
T9874 14057-14068 NN denotes observation
T9873 14053-14056 DT denotes The
T9872 14038-14052 NN denotes Erythropoiesis
T9871 14027-14037 JJ denotes Definitive
T9870 14024-14026 IN denotes in
T9869 14019-14023 NN denotes Role
T9868 14017-14018 DT denotes a
T9867 14008-14016 VB denotes Suggests
T9866 14003-14007 NN denotes Sox6
T9865 14000-14002 IN denotes of
T9864 13992-13999 NN denotes Pattern
T9863 13981-13991 NN denotes Expression
T9862 13977-13980 DT denotes The
T9893 14189-14193 NN denotes Sox6
T9892 14184-14188 IN denotes that
T9891 14175-14183 VB denotes suggests
T9890 14173-14174 -COMMA- denotes ,
T9889 14167-14173 VB denotes mature
T9888 14161-14166 NN denotes cells
T9887 14151-14160 JJ denotes erythroid
T9886 14140-14150 JJ denotes definitive
T9885 14134-14139 WRB denotes where
T9884 14132-14133 -COMMA- denotes ,
T9883 14127-14132 NN denotes liver
T9882 14124-14126 IN denotes in
T9881 14117-14123 NN denotes globin
T9880 14114-14116 JJ denotes ɛy
T9879 14106-14113 VB denotes express
T9324 13342-13346 NN denotes mice
T9323 13332-13341 JJ denotes Sox6-null
T9322 13329-13331 IN denotes in
T9321 13319-13328 NN denotes mechanism
T9320 13309-13318 NN denotes silencing
T9319 13306-13308 JJ denotes ɛy
T9318 13302-13305 DT denotes the
T9317 13299-13301 IN denotes of
T9316 13292-13298 NN denotes defect
T9315 13282-13291 JJ denotes intrinsic
T9314 13279-13281 DT denotes an
T9313 13276-13278 VB denotes is
T9312 13270-13275 EX denotes there
T9311 13265-13269 IN denotes that
T9310 13254-13264 VB denotes suggesting
T9309 13252-13253 -COMMA- denotes ,
T9308 13247-13252 NN denotes liver
T9307 13241-13246 JJ denotes fetal
T9306 13237-13240 DT denotes the
T9305 13234-13236 IN denotes in
T9304 13227-13233 VB denotes mature
T9303 13222-13226 WDT denotes that
T9302 13216-13221 NN denotes cells
T9301 13206-13215 JJ denotes erythroid
T9300 13195-13205 JJ denotes definitive
T9299 13191-13194 DT denotes the
T9298 13188-13190 IN denotes in
T9297 13177-13187 NN denotes expression
T9296 13169-13176 JJ denotes ectopic
T9295 13166-13168 TO denotes to
T9294 13162-13165 JJ denotes due
T9293 13158-13161 VB denotes are
T9292 13155-13157 NN denotes ɛy
T9291 13152-13154 IN denotes of
T9290 13145-13151 NN denotes levels
T9289 13140-13144 JJ denotes high
T9288 13129-13139 JJ denotes persistent
T9287 13125-13128 DT denotes the
T9286 13120-13124 IN denotes that
T9285 13108-13119 VB denotes demonstrate
T9284 13103-13107 NN denotes data
T9283 13097-13102 DT denotes These
T9282 13094-13095 -RRB- denotes )
T9281 13093-13094 NN denotes F
T9280 13089-13092 CC denotes and
T9279 13087-13088 NN denotes E
T9278 13085-13086 CD denotes 5
T9277 13078-13084 NN denotes Figure
T9276 13077-13078 -LRB- denotes (
T9275 13072-13076 NN denotes mice
T9274 13065-13071 JJ denotes mutant
T9273 13059-13064 NN denotes p100H
T9272 13055-13058 CC denotes and
T9271 13052-13054 NN denotes WT
T9270 13047-13051 CC denotes both
T9269 13044-13046 IN denotes in
T9268 13035-13043 JJ denotes abundant
T9267 13027-13034 RB denotes equally
T9266 13024-13026 VB denotes is
T9265 13017-13023 NN denotes globin
T9264 13008-13016 NN denotes βmaj/min
T9263 13005-13007 IN denotes of
T9262 12994-13004 NN denotes expression
T9261 12990-12993 DT denotes the
T9260 12988-12989 -COMMA- denotes ,
T9259 12981-12988 RB denotes However
T9258 12978-12979 -RRB- denotes )
T9257 12975-12978 NN denotes A–D
T9256 12973-12974 CD denotes 5
T9255 12966-12972 NN denotes Figure
T9254 12965-12966 -LRB- denotes (
T9253 12957-12964 NN denotes mutants
T9252 12948-12956 JJ denotes 14.5-dpc
T9251 12945-12947 IN denotes of
T9250 12939-12944 NN denotes liver
T9249 12935-12938 DT denotes the
T9248 12932-12934 IN denotes in
T9247 12927-12931 VB denotes seen
T9246 12924-12926 VB denotes is
T9245 12913-12923 NN denotes expression
T9244 12908-12912 NN denotes mRNA
T9243 12905-12907 JJ denotes ɛy
T9242 12897-12904 JJ denotes ectopic
T9241 12888-12896 JJ denotes abundant
T9240 12886-12887 -COMMA- denotes ,
T9239 12878-12886 NN denotes contrast
T9238 12875-12877 IN denotes In
T9237 12868-12873 NN denotes fetus
T9236 12864-12867 DT denotes the
T9235 12861-12863 IN denotes in
T9234 12846-12860 NN denotes erythropoiesis
T9233 12835-12845 JJ denotes definitive
T9232 12832-12834 IN denotes of
T9231 12827-12831 NN denotes site
T9230 12823-12826 DT denotes the
T9229 12821-12822 -COMMA- denotes ,
T9228 12816-12821 NN denotes liver
T9227 12807-12815 NN denotes 14.5-dpc
T9226 12804-12806 NN denotes WT
T9225 12800-12803 DT denotes the
T9224 12797-12799 IN denotes in
T9223 12787-12796 VB denotes expressed
T9222 12783-12786 RB denotes not
T9221 12780-12782 VB denotes is
T9220 12773-12779 NN denotes globin
T9219 12770-12772 JJ denotes ɛy
T9218 12768-12769 -COMMA- denotes ,
T9217 12760-12768 VB denotes expected
T9216 12757-12759 IN denotes As
T9215 12754-12755 -RRB- denotes )
T9214 12753-12754 CD denotes 5
T9213 12746-12752 NN denotes Figure
T9212 12745-12746 -LRB- denotes (
T9211 12731-12744 NN denotes hybridization
T9210 12726-12730 FW denotes situ
T9209 12723-12725 FW denotes in
T9208 12720-12722 IN denotes by
T9207 12712-12719 NN denotes embryos
T9206 12706-12711 NN denotes mouse
T9205 12703-12705 IN denotes in
T9204 12691-12702 NN denotes transcripts
T9203 12684-12690 NN denotes globin
T9202 12681-12683 JJ denotes ɛy
T9201 12678-12680 IN denotes of
T9200 12670-12677 NN denotes pattern
T9199 12662-12669 JJ denotes spatial
T9198 12658-12661 DT denotes the
T9197 12649-12657 VB denotes examined
T9196 12646-12648 PRP denotes we
T9195 12644-12645 -COMMA- denotes ,
T9194 12632-12644 NN denotes erythrocytes
T9193 12621-12631 JJ denotes definitive
T9192 12618-12620 IN denotes in
T9191 12611-12617 NN denotes globin
T9190 12608-12610 JJ denotes ɛy
T9189 12605-12607 IN denotes of
T9188 12594-12604 NN denotes expression
T9187 12586-12593 JJ denotes ectopic
T9186 12583-12585 TO denotes to
T9185 12579-12582 JJ denotes due
T9184 12576-12578 VB denotes is
T9183 12573-12575 CC denotes or
T9182 12560-12572 NN denotes erythrocytes
T9181 12550-12559 JJ denotes primitive
T9180 12541-12549 JJ denotes residual
T9179 12538-12540 TO denotes to
T9178 12534-12537 JJ denotes due
T9177 12531-12533 VB denotes is
T9176 12524-12530 NN denotes globin
T9175 12521-12523 JJ denotes ɛy
T9174 12518-12520 IN denotes of
T9173 12507-12517 NN denotes expression
T9172 12496-12506 JJ denotes persistent
T9171 12492-12495 DT denotes the
T9170 12484-12491 IN denotes whether
T9169 12474-12483 VB denotes determine
T9168 12471-12473 TO denotes To
T9167 12457-12469 NN denotes erythrocytes
T9166 12446-12456 JJ denotes definitive
T9165 12443-12445 IN denotes in
T9164 12434-12442 JJ denotes silenced
T9163 12430-12433 CC denotes and
T9162 12417-12429 NN denotes erythrocytes
T9161 12407-12416 JJ denotes primitive
T9160 12404-12406 IN denotes in
T9159 12394-12403 VB denotes expressed
T9158 12382-12393 RB denotes exclusively
T9157 12379-12381 VB denotes is
T9156 12374-12378 NN denotes gene
T9155 12367-12373 NN denotes globin
T9154 12364-12366 JJ denotes ɛy
T9153 12360-12363 DT denotes the
T9152 12358-12359 -COMMA- denotes ,
T9151 12350-12358 RB denotes Normally
T9150 12344-12349 NN denotes Cells
T9149 12334-12343 JJ denotes Erythroid
T9148 12323-12333 JJ denotes Definitive
T9147 12320-12322 IN denotes in
T9146 12310-12319 NN denotes Mechanism
T9145 12292-12309 JJ denotes ɛy-Gene–Silencing
T9144 12288-12291 DT denotes the
T9143 12285-12287 IN denotes in
T9142 12278-12284 NN denotes Defect
T9141 12276-12277 DT denotes a
T9140 12273-12275 TO denotes to
T9139 12269-12272 JJ denotes Due
T9138 12266-12268 VB denotes Is
T9137 12261-12265 NN denotes Mice
T9136 12246-12260 JJ denotes Sox6-Deficient
T9135 12243-12245 IN denotes in
T9134 12236-12242 NN denotes Globin
T9133 12233-12235 JJ denotes ɛy
T9132 12230-12232 IN denotes of
T9131 12219-12229 NN denotes Expression
T9130 12208-12218 JJ denotes Persistent
T9129 12204-12207 DT denotes The
T7964 11367-11368 DT denotes a
T7963 11364-11366 IN denotes as
T7962 11355-11363 RB denotes probably
T7961 11353-11354 -COMMA- denotes ,
T7960 11345-11353 NN denotes promoter
T7959 11342-11344 JJ denotes ɛy
T7958 11338-11341 DT denotes the
T7957 11335-11337 TO denotes to
T7956 11327-11334 VB denotes binding
T7955 11318-11326 RB denotes directly
T7954 11315-11317 IN denotes by
T7953 11310-11314 NN denotes gene
T7952 11307-11309 JJ denotes ɛy
T7951 11303-11306 DT denotes the
T7950 11300-11302 IN denotes of
T7949 11290-11299 NN denotes repressor
T7948 11288-11289 DT denotes a
T7947 11285-11287 IN denotes as
T7946 11280-11284 VB denotes acts
T7945 11275-11279 NN denotes Sox6
T7944 11270-11274 IN denotes that
T7943 11261-11269 VB denotes indicate
T7942 11253-11260 RB denotes clearly
T7941 11251-11252 -RRB- denotes )
T7940 11250-11251 CD denotes 4
T7939 11246-11249 CC denotes and
T7938 11244-11245 CD denotes 3
T7937 11236-11243 NN denotes Figures
T7936 11235-11236 -LRB- denotes (
T7935 11230-11234 NN denotes data
T7934 11224-11229 JJ denotes above
T7933 11220-11223 DT denotes The
T7932 11217-11218 -RRB- denotes )
T7931 11215-11217 NN denotes 4A
T7930 11208-11214 NN denotes Figure
T7929 11207-11208 -LRB- denotes (
T7928 11199-11206 NN denotes control
T7927 11190-11198 JJ denotes negative
T7926 11188-11189 DT denotes a
T7925 11185-11187 IN denotes as
T7924 11180-11184 VB denotes used
T7923 11176-11179 VB denotes was
T7922 11172-11175 NN denotes IgG
T7921 11165-11171 JJ denotes Normal
T7920 11158-11163 NN denotes cells
T7919 11152-11157 NN denotes liver
T7918 11148-11151 CC denotes and
T7917 11142-11147 NN denotes cells
T7916 11138-11141 NN denotes MEL
T7915 11133-11137 CC denotes both
T7914 11130-11132 IN denotes in
T7913 11121-11129 NN denotes antibody
T7912 11116-11120 NN denotes Sox6
T7911 11111-11115 IN denotes with
T7910 11092-11110 VB denotes immunoprecipitated
T7909 11084-11091 RB denotes readily
T7908 11081-11083 VB denotes is
T7907 11072-11080 NN denotes promoter
T7906 11063-11071 JJ denotes proximal
T7905 11060-11062 JJ denotes ɛy
T7904 11056-11059 DT denotes the
T7903 11051-11055 IN denotes that
T7902 11045-11050 NN denotes shows
T7901 11043-11044 CD denotes 4
T7900 11036-11042 NN denotes Figure
T7899 11026-11034 NN denotes antibody
T7898 11021-11025 NN denotes Sox6
T7897 11015-11020 VB denotes using
T7896 11010-11014 NN denotes mice
T7895 11007-11009 JJ denotes WT
T7894 11003-11006 NN denotes dpc
T7893 10998-11002 CD denotes 15.5
T7892 10995-10997 IN denotes of
T7891 10989-10994 NN denotes cells
T7890 10983-10988 NN denotes liver
T7889 10978-10982 IN denotes from
T7888 10975-10977 CC denotes or
T7887 10969-10974 NN denotes cells
T7886 10965-10968 NN denotes MEL
T7885 10960-10964 IN denotes from
T7884 10941-10959 VB denotes immunoprecipitated
T7883 10937-10940 VB denotes was
T7882 10929-10936 NN denotes complex
T7881 10913-10928 JJ denotes Sox6-containing
T7880 10909-10912 DT denotes The
T7879 10906-10907 -RRB- denotes )
T7878 10905-10906 CD denotes 4
T7877 10898-10904 NN denotes Figure
T7876 10897-10898 -LRB- denotes (
T7875 10895-10896 -RRB- denotes )
T7874 10891-10895 NN denotes ChIP
T7873 10890-10891 -LRB- denotes (
T7872 10870-10889 NN denotes immunoprecipitation
T7871 10860-10869 NN denotes chromatin
T7870 10854-10859 VB denotes using
T7869 10849-10853 FW denotes vivo
T7868 10846-10848 FW denotes in
T7867 10837-10845 NN denotes promoter
T7866 10834-10836 JJ denotes ɛy
T7865 10830-10833 DT denotes the
T7864 10827-10829 TO denotes to
T7863 10821-10826 VB denotes binds
T7862 10816-10820 NN denotes Sox6
T7861 10808-10815 IN denotes whether
T7860 10801-10807 VB denotes tested
T7859 10796-10800 RB denotes also
T7858 10793-10795 PRP denotes We
T7857 10785-10791 NN denotes degree
T7856 10780-10784 JJ denotes same
T7855 10776-10779 DT denotes the
T7854 10773-10775 TO denotes to
T7853 10769-10772 RB denotes not
T7852 10765-10768 CC denotes but
T7851 10763-10764 -COMMA- denotes ,
T7850 10759-10763 NN denotes Sox6
T7849 10756-10758 IN denotes by
T7848 10753-10755 NN denotes ɛy
T7847 10750-10752 IN denotes of
T7846 10739-10749 NN denotes repression
T7845 10731-10738 JJ denotes maximal
T7844 10727-10730 IN denotes for
T7843 10718-10726 VB denotes required
T7842 10714-10717 VB denotes are
T7841 10708-10713 NN denotes sites
T7840 10703-10707 DT denotes both
T7839 10701-10702 -COMMA- denotes ,
T7838 10697-10701 RB denotes Thus
T7837 10694-10695 -RRB- denotes )
T7836 10692-10694 NN denotes 3F
T7835 10685-10691 NN denotes Figure
T7834 10684-10685 -LRB- denotes (
T7833 10676-10683 NN denotes studies
T7832 10663-10675 NN denotes transfection
T7831 10660-10662 IN denotes in
T7830 10649-10659 NN denotes repression
T7829 10640-10648 NN denotes promoter
T7828 10628-10639 JJ denotes significant
T7827 10625-10627 IN denotes in
T7826 10618-10624 VB denotes result
T7825 10614-10617 RB denotes not
T7824 10611-10613 VB denotes do
T7823 10609-10610 -RRB- denotes )
T7822 10598-10609 VB denotes mutagenized
T7821 10592-10597 NN denotes sites
T7820 10584-10591 NN denotes binding
T7819 10575-10583 NN denotes Sox/Sox6
T7818 10570-10574 CC denotes both
T7817 10567-10569 CC denotes or
T7816 10563-10566 CD denotes one
T7815 10556-10562 CC denotes either
T7814 10551-10555 IN denotes with
T7813 10550-10551 -LRB- denotes (
T7812 10539-10549 NN denotes constructs
T7811 10530-10538 NN denotes reporter
T7810 10521-10529 NN denotes promoter
T7809 10518-10520 JJ denotes ɛy
T7808 10511-10517 JJ denotes mutant
T7807 10507-10510 DT denotes the
T7806 10505-10506 -COMMA- denotes ,
T7805 10498-10505 NN denotes results
T7804 10493-10497 NN denotes EMSA
T7803 10489-10492 DT denotes the
T7802 10484-10488 IN denotes with
T7801 10473-10483 JJ denotes Consistent
T7800 10466-10471 NN denotes cells
T7799 10460-10465 NN denotes GM979
T7798 10455-10459 IN denotes into
T7797 10448-10454 NN denotes vector
T7796 10433-10447 NN denotes overexpression
T7795 10428-10432 NN denotes Sox6
T7794 10424-10427 DT denotes the
T7793 10419-10423 IN denotes with
T7792 10404-10418 VB denotes co-transfected
T7791 10399-10403 VB denotes were
T7790 10393-10398 NN denotes sites
T7789 10385-10392 NN denotes binding
T7788 10376-10384 NN denotes Sox/Sox6
T7787 10364-10375 VB denotes mutagenized
T7786 10359-10363 IN denotes with
T7785 10348-10358 NN denotes constructs
T7784 10339-10347 NN denotes reporter
T7783 10330-10338 NN denotes promoter
T7782 10327-10329 JJ denotes ɛy
T7781 10323-10326 DT denotes the
T7780 10321-10322 -COMMA- denotes ,
T7779 10316-10321 NN denotes sites
T7778 10308-10315 NN denotes binding
T7777 10299-10307 NN denotes Sox/Sox6
T7776 10292-10298 JJ denotes intact
T7775 10288-10291 DT denotes the
T7774 10285-10287 IN denotes of
T7773 10272-10284 NN denotes significance
T7772 10261-10271 JJ denotes functional
T7771 10257-10260 DT denotes the
T7770 10245-10256 VB denotes investigate
T7769 10242-10244 TO denotes To
T7768 10233-10240 NN denotes binding
T7767 10230-10232 NN denotes WT
T7766 10225-10229 IN denotes with
T7765 10215-10224 RB denotes partially
T7764 10207-10214 VB denotes compete
T7763 10203-10206 MD denotes may
T7762 10197-10202 NN denotes probe
T7761 10190-10196 JJ denotes mutant
T7760 10187-10189 NN denotes M2
T7759 10183-10186 DT denotes The
T7712 9939-9945 JJ denotes intact
T7711 9935-9938 DT denotes The
T7710 9932-9933 -RRB- denotes )
T7709 9930-9932 NN denotes 3D
T7708 9923-9929 NN denotes Figure
T7707 9922-9923 -LRB- denotes (
T7706 9916-9921 NN denotes cells
T7705 9912-9915 NN denotes MEL
T7704 9909-9911 IN denotes in
T7703 9900-9908 NN denotes sequence
T7702 9896-9899 NN denotes DNA
T7701 9891-9895 DT denotes this
T7700 9888-9890 TO denotes to
T7699 9882-9887 VB denotes binds
T7698 9873-9881 RB denotes directly
T7697 9868-9872 NN denotes Sox6
T7696 9865-9866 -RRB- denotes ]
T7695 9863-9865 CD denotes 33
T7694 9862-9863 -LRB- denotes [
T7693 9859-9861 VB denotes ɛy
T7692 9855-9858 RB denotes not
T7691 9851-9854 CC denotes but
T7690 9849-9850 -COMMA- denotes ,
T7689 9842-9849 NN denotes globins
T7688 9840-9841 NN denotes β
T7687 9834-9839 JJ denotes adult
T7686 9826-9833 VB denotes express
T7685 9824-9825 -COMMA- denotes ,
T7684 9820-9824 NN denotes line
T7683 9815-9819 NN denotes cell
T7682 9799-9814 JJ denotes erythroleukemic
T7681 9792-9798 JJ denotes murine
T7680 9790-9791 DT denotes a
T7679 9788-9789 -COMMA- denotes ,
T7678 9783-9788 NN denotes cells
T7677 9779-9782 NN denotes MEL
T7676 9772-9777 NN denotes probe
T7675 9766-9771 JJ denotes 36-bp
T7674 9761-9765 JJ denotes same
T7673 9757-9760 DT denotes the
T7672 9747-9756 VB denotes employing
T7671 9742-9746 NN denotes EMSA
T7670 9739-9741 IN denotes in
T7669 9734-9738 VB denotes used
T7668 9729-9733 VB denotes were
T7667 9723-9728 NN denotes cells
T7666 9719-9722 NN denotes MEL
T7665 9714-9718 IN denotes from
T7664 9705-9713 NN denotes extracts
T7663 9697-9704 JJ denotes nuclear
T7662 9695-9696 -COMMA- denotes ,
T7661 9691-9695 RB denotes Next
T7660 9688-9689 -RRB- denotes )
T7659 9686-9688 NN denotes 3C
T7658 9679-9685 NN denotes Figure
T7657 9678-9679 -LRB- denotes (
T7656 9670-9677 NN denotes results
T7655 9664-9669 DT denotes these
T7654 9654-9663 VB denotes confirmed
T7653 9649-9653 WDT denotes that
T7652 9644-9648 NN denotes EMSA
T7651 9636-9643 DT denotes another
T7650 9633-9635 IN denotes in
T7649 9628-9632 VB denotes used
T7648 9624-9627 VB denotes was
T7647 9619-9623 NN denotes Sox6
T7646 9609-9618 JJ denotes HA-tagged
T7645 9606-9608 DT denotes an
T7644 9604-9605 -COMMA- denotes ,
T7643 9599-9604 NN denotes probe
T7642 9595-9598 DT denotes the
T7641 9592-9594 TO denotes to
T7640 9586-9591 VB denotes binds
T7639 9579-9585 PRP denotes itself
T7638 9575-9578 NN denotes tag
T7637 9569-9574 NN denotes c-Myc
T7636 9565-9568 DT denotes the
T7635 9560-9564 IN denotes that
T7634 9548-9559 NN denotes possibility
T7633 9544-9547 DT denotes the
T7632 9540-9543 RP denotes out
T7631 9535-9539 VB denotes rule
T7630 9532-9534 TO denotes To
T7629 9517-9530 JJ denotes Sox6-specific
T7628 9514-9516 VB denotes is
T7627 9506-9513 NN denotes binding
T7626 9502-9505 DT denotes the
T7625 9497-9501 IN denotes that
T7624 9486-9496 VB denotes indicating
T7623 9484-9485 -COMMA- denotes ,
T7622 9480-9484 NN denotes band
T7621 9476-9479 DT denotes the
T7620 9465-9475 VB denotes supershift
T7619 9454-9464 NN denotes antibodies
T7618 9449-9453 NN denotes Sox6
T7617 9445-9448 CC denotes and
T7616 9439-9444 NN denotes c-Myc
T7615 9434-9438 CC denotes both
T7614 9432-9433 -COMMA- denotes ,
T7613 9424-9432 RB denotes Moreover
T7612 9415-9422 NN denotes protein
T7611 9410-9414 NN denotes Sox6
T7610 9403-9409 VB denotes tagged
T7609 9399-9402 DT denotes the
T7608 9396-9398 IN denotes by
T7607 9388-9395 VB denotes shifted
T7606 9384-9387 VB denotes was
T7605 9378-9383 NN denotes probe
T7604 9372-9377 JJ denotes 36-bp
T7603 9368-9371 DT denotes The
T7602 9365-9366 -RRB- denotes )
T7601 9363-9365 NN denotes 2C
T7600 9356-9362 NN denotes Figure
T7599 9355-9356 -LRB- denotes (
T7598 9343-9354 NN denotes experiments
T7597 9334-9342 NN denotes analysis
T7596 9325-9333 NN denotes deletion
T7595 9321-9324 DT denotes the
T7594 9318-9320 IN denotes by
T7593 9310-9317 VB denotes defined
T7592 9301-9309 NN denotes promoter
T7591 9298-9300 JJ denotes ɛy
T7590 9294-9297 DT denotes the
T7589 9287-9293 IN denotes within
T7588 9285-9286 -RRB- denotes )
T7587 9283-9285 NN denotes 3B
T7586 9276-9282 NN denotes Figure
T7585 9275-9276 -LRB- denotes (
T7584 9268-9274 NN denotes region
T7583 9262-9267 JJ denotes 36-bp
T7582 9258-9261 DT denotes the
T7581 9253-9257 IN denotes with
T7580 9243-9252 VB denotes associate
T7579 9232-9242 RB denotes physically
T7578 9229-9231 TO denotes to
T7577 9224-9228 JJ denotes able
T7576 9221-9223 VB denotes is
T7575 9216-9220 NN denotes Sox6
T7574 9213-9214 -RRB- denotes )
T7573 9211-9213 NN denotes 3A
T7572 9204-9210 NN denotes Figure
T7571 9203-9204 -LRB- denotes (
T7570 9197-9202 NN denotes sites
T7569 9189-9196 NN denotes binding
T7568 9180-9188 NN denotes Sox/Sox6
T7567 9177-9179 IN denotes in
T7566 9175-9176 -RRB- denotes )
T7565 9173-9175 NN denotes M3
T7564 9169-9172 CC denotes and
T7563 9166-9168 NN denotes M2
T7562 9165-9166 -LRB- denotes (
T7561 9157-9164 VB denotes mutated
T7560 9154-9156 CC denotes or
T7559 9152-9153 -COMMA- denotes ,
T7558 9151-9152 -RRB- denotes )
T7557 9149-9151 NN denotes M1
T7556 9148-9149 -LRB- denotes (
T7555 9138-9147 VB denotes truncated
T7554 9131-9137 CC denotes either
T7553 9129-9130 -COMMA- denotes ,
T7552 9126-9129 VB denotes are
T7551 9121-9125 WDT denotes that
T7550 9114-9120 NN denotes probes
T7549 9106-9113 VB denotes mutated
T7548 9100-9105 CD denotes three
T7547 9096-9099 VB denotes are
T7546 9091-9095 NN denotes EMSA
T7545 9087-9090 PRP-DOLLAR- denotes our
T7544 9084-9086 IN denotes in
T7543 9075-9083 VB denotes included
T7542 9070-9074 RB denotes Also
T7541 9063-9068 NN denotes sites
T7540 9055-9062 NN denotes binding
T7539 9046-9054 NN denotes Sox/Sox6
T7538 9036-9045 NN denotes consensus
T7537 9032-9035 CD denotes two
T7536 9023-9031 VB denotes contains
T7535 9017-9022 NN denotes probe
T7534 9012-9016 DT denotes This
T7533 9002-9010 NN denotes analyses
T7532 8993-9001 NN denotes deletion
T7531 8984-8992 NN denotes promoter
T7530 8980-8983 PRP-DOLLAR- denotes our
T7529 8977-8979 IN denotes in
T7528 8969-8976 VB denotes defined
T7527 8960-8968 NN denotes promoter
T7526 8957-8959 JJ denotes ɛy
T7525 8953-8956 DT denotes the
T7524 8950-8952 IN denotes of
T7523 8943-8949 NN denotes region
T7522 8934-8942 JJ denotes critical
T7521 8930-8933 DT denotes the
T7520 8927-8929 TO denotes to
T7519 8915-8926 VB denotes corresponds
T7518 8909-8914 NN denotes probe
T7517 8906-8908 NN denotes WT
T7516 8904-8905 -RRB- denotes )
T7515 8902-8904 NN denotes bp
T7514 8901-8902 -LRB- denotes (
T7513 8896-8900 NN denotes pair
T7512 8888-8895 NN denotes 36–base
T7511 8884-8887 DT denotes The
T7510 8880-8882 NN denotes 3A
T7509 8873-8879 NN denotes Figure
T7508 8870-8872 IN denotes in
T7507 8863-8869 VB denotes listed
T7506 8859-8862 VB denotes are
T7505 8854-8858 VB denotes used
T7504 8847-8853 NN denotes probes
T7503 8843-8846 DT denotes The
T7502 8835-8841 NN denotes system
T7501 8829-8834 FW denotes vitro
T7500 8826-8828 FW denotes in
T7499 8800-8825 NN denotes transcription/translation
T7498 8787-8799 JJ denotes lysate-based
T7497 8774-8786 NN denotes reticulocyte
T7443 8439-8442 DT denotes the
T7442 8436-8438 TO denotes to
T7441 8430-8435 VB denotes Binds
T7440 8421-8429 RB denotes Directly
T7439 8416-8420 NN denotes Sox6
T7438 8411-8415 IN denotes that
T7437 8406-8410 NNP denotes Show
T7436 8399-8405 NNP denotes Assays
T7435 8394-8398 NNP denotes ChIP
T7434 8390-8393 CC denotes and
T7433 8385-8389 NN denotes EMSA
T7758 10180-10181 -RRB- denotes )
T7757 10178-10180 NN denotes 3E
T7756 10171-10177 NN denotes Figure
T7755 10170-10171 -LRB- denotes (
T7754 10165-10169 NN denotes EMSA
T7753 10162-10164 IN denotes in
T7752 10154-10161 VB denotes compete
T7751 10151-10153 TO denotes to
T7750 10143-10150 NN denotes ability
T7749 10137-10142 PRP-DOLLAR- denotes their
T7748 10129-10136 VB denotes abolish
T7747 10127-10128 -RRB- denotes )
T7746 10125-10127 NN denotes M3
T7745 10121-10124 CC denotes and
T7744 10118-10120 NN denotes M1
T7743 10117-10118 -LRB- denotes (
T7742 10111-10116 NN denotes sites
T7741 10103-10110 NN denotes binding
T7740 10094-10102 NN denotes Sox/Sox6
T7739 10085-10093 JJ denotes putative
T7738 10082-10084 IN denotes of
T7737 10073-10081 NN denotes Ablation
T7736 10070-10071 -RRB- denotes )
T7735 10068-10070 NN denotes 3E
T7734 10061-10067 NN denotes Figure
T7733 10060-10061 -LRB- denotes (
T7732 10054-10059 NN denotes assay
T7731 10042-10053 NN denotes competition
T7730 10038-10041 DT denotes the
T7729 10035-10037 IN denotes in
T7728 10029-10034 VB denotes shown
T7727 10026-10028 IN denotes as
T7726 10024-10025 -COMMA- denotes ,
T7725 10017-10024 NN denotes binding
T7724 10013-10016 DT denotes the
T7723 10009-10012 IN denotes for
T7722 10000-10008 VB denotes required
T7721 9996-9999 VB denotes are
T7720 9990-9995 NN denotes probe
T7719 9986-9989 NN denotes DNA
T7718 9982-9985 DT denotes the
T7717 9979-9981 IN denotes of
T7716 9973-9978 NN denotes sites
T7715 9965-9972 NN denotes binding
T7714 9956-9964 NN denotes Sox/Sox6
T7713 9946-9955 NN denotes consensus
T7466 8589-8592 DT denotes the
T7496 8772-8773 DT denotes a
T7495 8769-8771 IN denotes in
T7494 8764-8768 NN denotes Sox6
T7493 8751-8763 JJ denotes c-Myc-tagged
T7492 8749-8750 DT denotes a
T7491 8743-8748 VB denotes using
T7490 8741-8742 -RRB- denotes )
T7489 8737-8741 NN denotes EMSA
T7488 8736-8737 -LRB- denotes (
T7487 8729-8735 NN denotes assays
T7486 8723-8728 NN denotes shift
T7485 8714-8722 NN denotes mobility
T7484 8698-8713 JJ denotes electrophoretic
T7483 8688-8697 VB denotes performed
T7482 8682-8687 RB denotes first
T7481 8679-8681 PRP denotes we
T7480 8677-8678 -COMMA- denotes ,
T7479 8669-8677 NN denotes promoter
T7478 8666-8668 JJ denotes ɛy
T7477 8662-8665 DT denotes the
T7476 8657-8661 IN denotes with
T7475 8646-8656 VB denotes associated
T7474 8637-8645 RB denotes directly
T7473 8634-8636 VB denotes is
T7472 8629-8633 NN denotes Sox6
T7471 8621-8628 IN denotes whether
T7470 8609-8620 VB denotes investigate
T7469 8606-8608 TO denotes To
T7468 8596-8604 NN denotes promoter
T7467 8593-8595 JJ denotes ɛy
T7465 8579-8588 VB denotes affecting
T7464 8565-8578 NN denotes intermediates
T7463 8554-8564 VB denotes regulating
T7462 8551-8553 IN denotes by
T7461 8548-8550 CC denotes or
T7460 8539-8547 NN denotes promoter
T7459 8535-8538 DT denotes the
T7458 8530-8534 IN denotes with
T7457 8522-8529 NN denotes contact
T7456 8513-8521 JJ denotes physical
T7455 8506-8512 JJ denotes direct
T7454 8498-8505 IN denotes through
T7453 8491-8497 CC denotes either
T7452 8489-8490 -COMMA- denotes ,
T7451 8481-8489 NN denotes promoter
T7450 8478-8480 JJ denotes ɛy
T7449 8474-8477 DT denotes the
T7448 8466-8473 VB denotes repress
T7447 8460-8465 MD denotes might
T7446 8455-8459 NN denotes Sox6
T7445 8446-8454 NN denotes Promoter
T7444 8443-8445 JJ denotes ɛy
T6147 5524-5532 NN denotes promoter
T6146 5521-5523 JJ denotes ɛy
T6145 5517-5520 DT denotes the
T6144 5507-5516 VB denotes represses
T6143 5502-5506 NN denotes Sox6
T6142 5497-5501 IN denotes that
T6141 5486-5496 VB denotes indicating
T6140 5484-5485 -COMMA- denotes ,
T6139 5483-5484 -RRB- denotes )
T6138 5481-5483 NN denotes 2B
T6137 5474-5480 NN denotes Figure
T6136 5473-5474 -LRB- denotes (
T6135 5467-5472 NN denotes assay
T6134 5454-5466 NN denotes transfection
T6133 5450-5453 DT denotes the
T6132 5447-5449 IN denotes in
T6131 5438-5446 NN denotes promoter
T6130 5435-5437 JJ denotes ɛy
T6129 5431-5434 DT denotes the
T6128 5423-5430 VB denotes repress
T6127 5420-5422 TO denotes to
T6126 5412-5419 NN denotes ability
T6125 5408-5411 DT denotes the
T6124 5400-5407 VB denotes retains
T6123 5395-5399 NN denotes Sox6
T6122 5392-5394 IN denotes of
T6121 5384-5391 NN denotes version
T6120 5377-5383 JJ denotes mutant
T6119 5372-5376 DT denotes this
T6118 5370-5371 -COMMA- denotes ,
T6117 5363-5370 RB denotes However
T6116 5355-5361 NN denotes domain
T6115 5347-5354 NN denotes binding
T6114 5343-5346 NN denotes DNA
T6113 5339-5342 NN denotes HMG
T6112 5335-5338 DT denotes the
T6111 5332-5334 IN denotes in
T6110 5328-5331 RB denotes not
T6109 5325-5327 VB denotes is
T6108 5318-5324 NN denotes change
T6107 5313-5317 NN denotes acid
T6106 5307-5312 JJ denotes amino
T6105 5302-5306 DT denotes This
T6104 5299-5300 -RRB- denotes ]
T6103 5298-5299 CD denotes 5
T6102 5297-5298 -LRB- denotes [
T6101 5285-5296 NN denotes interaction
T6100 5274-5284 JJ denotes Sox6-CtBP2
T6099 5266-5273 VB denotes abolish
T6098 5263-5265 TO denotes to
T6097 5252-5262 JJ denotes sufficient
T6096 5249-5251 VB denotes be
T6095 5246-5248 TO denotes to
T6094 5237-5245 VB denotes reported
T6093 5226-5236 RB denotes previously
T6092 5221-5225 VB denotes been
T6091 5217-5220 VB denotes has
T6090 5212-5216 WDT denotes that
T6089 5204-5211 NN denotes protein
T6088 5199-5203 NN denotes Sox6
T6087 5195-5198 DT denotes the
T6086 5192-5194 IN denotes in
T6085 5190-5191 -RRB- denotes )
T6084 5185-5190 NN denotes L386H
T6083 5184-5185 -LRB- denotes (
T6082 5175-5183 NN denotes mutation
T6081 5169-5174 NN denotes point
T6080 5167-5168 DT denotes a
T6079 5156-5166 VB denotes introduced
T6078 5153-5155 PRP denotes we
T6077 5151-5152 -COMMA- denotes ,
T6076 5143-5151 NN denotes promoter
T6075 5140-5142 JJ denotes ɛy
T6074 5136-5139 DT denotes the
T6073 5133-5135 IN denotes of
T6072 5122-5132 NN denotes repression
T6071 5117-5121 NN denotes Sox6
T6070 5113-5116 IN denotes for
T6069 5104-5112 VB denotes required
T6068 5101-5103 VB denotes is
T6067 5095-5100 NN denotes CtBP2
T6066 5090-5094 IN denotes with
T6065 5078-5089 NN denotes interaction
T6064 5074-5077 DT denotes the
T6063 5066-5073 IN denotes whether
T6062 5054-5065 VB denotes investigate
T6061 5051-5053 TO denotes To
T6060 5048-5049 -RRB- denotes )
T6059 5044-5048 NN denotes data
T6058 5032-5043 JJ denotes unpublished
T6057 5031-5032 -LRB- denotes (
T6056 5025-5030 NN denotes cells
T6055 5019-5024 NN denotes GM979
T6054 5016-5018 IN denotes in
T6053 5006-5015 VB denotes expressed
T6052 5003-5005 VB denotes is
T6051 4997-5002 NN denotes CtBP2
T6050 4994-4995 -RRB- denotes ]
T6049 4993-4994 CD denotes 5
T6048 4992-4993 -LRB- denotes [
T6047 4983-4991 NN denotes promoter
T6046 4977-4982 NN denotes fgf-3
T6045 4973-4976 DT denotes the
T6044 4970-4972 IN denotes on
T6043 4968-4969 -COMMA- denotes ,
T6042 4963-4968 NN denotes CtBP2
T6041 4961-4962 -COMMA- denotes ,
T6040 4949-4961 NN denotes co-repressor
T6039 4939-4948 VB denotes expressed
T6038 4932-4938 RB denotes widely
T6037 4930-4931 DT denotes a
T6036 4925-4929 IN denotes with
T6035 4916-4924 VB denotes interact
T6034 4913-4915 TO denotes to
T6033 4909-4912 CC denotes and
T6032 4899-4908 NN denotes repressor
T6031 4897-4898 DT denotes a
T6030 4894-4896 IN denotes as
T6029 4890-4893 VB denotes act
T6028 4887-4889 TO denotes to
T6027 4881-4886 VB denotes shown
T6026 4876-4880 VB denotes been
T6025 4872-4875 VB denotes has
T6024 4867-4871 NN denotes Sox6
T6023 3479-3484 NN denotes level
T6022 3463-3478 JJ denotes transcriptional
T6021 3459-3462 DT denotes the
T6020 3456-3458 IN denotes at
T6019 3447-3455 NN denotes promoter
T6018 3444-3446 JJ denotes ɛy
T6017 3440-3443 DT denotes the
T6016 3432-3439 VB denotes repress
T6015 3429-3431 TO denotes to
T6014 3424-3428 VB denotes acts
T6013 3419-3423 NN denotes Sox6
T6012 3414-3418 IN denotes that
T6011 3405-3413 VB denotes indicate
T6010 3400-3404 NN denotes data
T6009 3394-3399 DT denotes These
T6008 3391-3392 -RRB- denotes )
T6007 3389-3391 NN denotes 2B
T6006 3382-3388 NN denotes Figure
T6005 3381-3382 -LRB- denotes (
T6004 3372-3380 NN denotes activity
T6003 3366-3371 NN denotes E-Luc
T6002 3358-3365 VB denotes repress
T6001 3355-3357 TO denotes to
T6000 3349-3354 VB denotes fails
T5999 3347-3348 -RRB- denotes )
T5998 3341-3347 NN denotes allele
T5997 3335-3340 NN denotes mouse
T5996 3328-3334 NN denotes p 100H
T5995 3324-3327 DT denotes the
T5994 3321-3323 TO denotes to
T5993 3313-3320 JJ denotes similar
T5992 3312-3313 -LRB- denotes (
T5991 3310-3311 -RRB- denotes ]
T5990 3308-3310 CD denotes 32
T5989 3307-3308 -LRB- denotes [
T5988 3300-3306 NN denotes domain
T5987 3296-3299 NN denotes HMG
T5986 3292-3295 PRP-DOLLAR- denotes its
T5985 3286-3291 VB denotes lacks
T5984 3281-3285 WDT denotes that
T5983 3273-3280 NN denotes protein
T5982 3268-3272 NN denotes Sox6
T5981 3258-3267 VB denotes truncated
T5980 3256-3257 DT denotes a
T5979 3253-3255 IN denotes of
T5978 3238-3252 NN denotes overexpression
T5977 3236-3237 -COMMA- denotes ,
T5976 3228-3236 NN denotes contrast
T5975 3225-3227 IN denotes In
T5974 3222-3223 -RRB- denotes )
T5973 3220-3222 NN denotes 2B
T5972 3213-3219 NN denotes Figure
T5971 3212-3213 -LRB- denotes (
T5970 3203-3211 NN denotes activity
T5969 3194-3202 NN denotes reporter
T5968 3188-3193 NN denotes E-Luc
T5967 3185-3187 IN denotes of
T5966 3174-3184 NN denotes repression
T5965 3157-3173 JJ denotes dosage-dependent
T5964 3155-3156 DT denotes a
T5963 3152-3154 TO denotes to
T5962 3146-3151 VB denotes leads
T5961 3133-3145 NN denotes transfection
T5960 3123-3132 JJ denotes transient
T5959 3120-3122 IN denotes by
T5958 3114-3119 NN denotes cells
T5957 3108-3113 NN denotes GM979
T5956 3105-3107 IN denotes in
T5955 3100-3104 NN denotes Sox6
T5954 3097-3099 IN denotes of
T5953 3082-3096 NN denotes Overexpression
T5952 3079-3080 -RRB- denotes )
T5951 3072-3079 NNP denotes Methods
T5950 3068-3071 CC denotes and
T5949 3058-3067 NNP denotes Materials
T5948 3055-3057 IN denotes in
T5947 3046-3054 VB denotes detailed
T5946 3045-3046 -LRB- denotes (
T5945 3042-3044 NN denotes 2A
T5944 3035-3041 NN denotes Figure
T5943 3032-3034 IN denotes in
T5942 3026-3031 VB denotes shown
T5941 3023-3025 IN denotes as
T5940 3021-3022 -COMMA- denotes ,
T5939 3017-3021 NN denotes gene
T5938 3008-3016 NN denotes reporter
T5937 2997-3007 NN denotes luciferase
T5936 2993-2996 DT denotes the
T5935 2990-2992 IN denotes by
T5934 2981-2989 VB denotes followed
T5933 2979-2980 -COMMA- denotes ,
T5932 2978-2979 -RRB- denotes )
T6201 5814-5815 -RRB- denotes )
T6200 5812-5814 NN denotes 3A
T6199 5805-5811 NN denotes Figure
T6198 5804-5805 -LRB- denotes (
T6197 5802-5803 -RRB- denotes ]
T6196 5801-5802 CD denotes 5
T6195 5800-5801 -LRB- denotes [
T6194 5794-5799 NN denotes sites
T6193 5786-5793 NN denotes binding
T6192 5776-5785 NN denotes consensus
T6191 5767-5775 NN denotes Sox/Sox6
T6190 5763-5766 CD denotes two
T6189 5755-5762 VB denotes reveals
T6188 5748-5754 NN denotes region
T6187 5742-5747 JJ denotes short
T6186 5737-5741 DT denotes this
T6185 5734-5736 IN denotes of
T6184 5725-5733 NN denotes Analysis
T6183 5713-5723 NN denotes repression
T6182 5708-5712 NN denotes Sox6
T6181 5704-5707 IN denotes for
T6180 5695-5703 JJ denotes critical
T6179 5692-5694 VB denotes is
T6178 5687-5691 WDT denotes that
T6177 5678-5686 NN denotes promoter
T6176 5669-5677 JJ denotes proximal
T6175 5666-5668 JJ denotes ɛy
T6174 5662-5665 DT denotes the
T6173 5655-5661 IN denotes within
T6172 5653-5654 -RRB- denotes )
T6171 5650-5653 CD denotes −37
T6170 5647-5649 TO denotes to
T6169 5643-5646 CD denotes −63
T6168 5642-5643 -LRB- denotes (
T6167 5635-5641 NN denotes region
T6166 5633-5634 DT denotes a
T6165 5625-5632 VB denotes defined
T6164 5623-5624 -COMMA- denotes ,
T6163 5621-5623 NN denotes 2C
T6162 5614-5620 NN denotes Figure
T6161 5611-5613 IN denotes in
T6160 5605-5610 VB denotes shown
T6159 5602-5604 IN denotes as
T6158 5600-5601 -COMMA- denotes ,
T6157 5592-5600 NN denotes promoter
T6156 5589-5591 JJ denotes ɛy
T6155 5585-5588 DT denotes the
T6154 5582-5584 IN denotes of
T6153 5573-5581 NN denotes analysis
T6152 5564-5572 NN denotes Deletion
T6151 5556-5562 NN denotes manner
T6150 5538-5555 JJ denotes CtBP2-independent
T6149 5536-5537 DT denotes a
T6148 5533-5535 IN denotes in
T5931 2976-2978 NN denotes kb
T5930 2972-2975 CD denotes 2.2
T5929 2971-2972 -LRB- denotes (
T5928 2962-2970 NN denotes promoter
T5927 2953-2961 JJ denotes proximal
T5926 2950-2952 JJ denotes ɛy
T5925 2946-2949 DT denotes the
T5924 2943-2945 TO denotes to
T5923 2941-2942 -RRB- denotes ]
T5922 2939-2941 CD denotes 31
T5921 2938-2939 -LRB- denotes [
T5920 2936-2937 -RRB- denotes )
T5919 2934-2936 NN denotes kb
T5918 2930-2933 CD denotes 2.5
T5917 2929-2930 -LRB- denotes (
T5916 2921-2928 NN denotes element
T5915 2919-2920 -RRB- denotes )
T5914 2915-2919 NN denotes μLCR
T5913 2914-2915 -LRB- denotes (
T5912 2904-2913 NN denotes micro-LCR
T5911 2902-2903 DT denotes a
T5910 2895-2901 VB denotes fusing
T5909 2892-2894 IN denotes by
T5908 2890-2891 -RRB- denotes )
T5907 2885-2890 NN denotes E-Luc
T5906 2884-2885 -LRB- denotes (
T5905 2874-2883 NN denotes construct
T5904 2865-2873 NN denotes reporter
T5903 2856-2864 NN denotes promoter
T5902 2853-2855 JJ denotes ɛy
T5901 2850-2852 DT denotes an
T5900 2840-2849 VB denotes generated
T5899 2837-2839 PRP denotes We
T5898 2834-2835 -RRB- denotes ]
T5897 2832-2834 CD denotes 30
T5896 2831-2832 -LRB- denotes [
T5895 2823-2830 NN denotes globins
T5894 2818-2822 NN denotes beta
T5893 2812-2817 JJ denotes adult
T5892 2808-2811 CC denotes and
T5891 2805-2807 JJ denotes ɛy
T5890 2800-2804 CC denotes both
T5889 2790-2799 VB denotes expresses
T5888 2785-2789 WDT denotes that
T5887 2780-2784 NN denotes line
T5886 2775-2779 NN denotes cell
T5885 2759-2774 JJ denotes erythroleukemic
T5884 2752-2758 JJ denotes murine
T5883 2750-2751 DT denotes a
T5882 2748-2749 -COMMA- denotes ,
T5881 2743-2748 NN denotes cells
T5880 2737-2742 NN denotes GM979
T5879 2733-2736 CC denotes and
T5878 2727-2732 NN denotes assay
T5877 2714-2726 NN denotes transfection
T5876 2704-2713 JJ denotes transient
T5875 2698-2703 FW denotes vitro
T5874 2695-2697 FW denotes in
T5873 2692-2694 DT denotes an
T5872 2687-2691 VB denotes used
T5871 2684-2686 PRP denotes we
T5870 2682-2683 -COMMA- denotes ,
T5869 2677-2682 NN denotes level
T5868 2661-2676 JJ denotes transcriptional
T5867 2657-2660 DT denotes the
T5866 2654-2656 IN denotes at
T5865 2645-2653 NN denotes promoter
T5864 2640-2644 NN denotes gene
T5863 2637-2639 JJ denotes ɛy
T5862 2633-2636 DT denotes the
T5861 2630-2632 IN denotes on
T5860 2625-2629 VB denotes acts
T5859 2616-2624 RB denotes directly
T5858 2611-2615 NN denotes Sox6
T5857 2603-2610 IN denotes whether
T5856 2591-2602 VB denotes investigate
T5855 2588-2590 TO denotes To
T5854 2578-2586 NN denotes promoter
T5853 2575-2577 JJ denotes ɛy
T5852 2571-2574 DT denotes the
T5851 2568-2570 IN denotes of
T5850 2559-2567 NN denotes activity
T5849 2543-2558 JJ denotes transcriptional
T5848 2539-2542 RB denotes not
T5847 2537-2538 -COMMA- denotes ,
T5846 2533-2537 NN denotes mRNA
T5845 2530-2532 JJ denotes ɛy
T5844 2527-2529 IN denotes of
T5843 2520-2526 NN denotes levels
T5842 2507-2519 JJ denotes steady-state
T5841 2499-2506 NN denotes measure
T5840 2497-2498 -RRB- denotes )
T5839 2496-2497 CD denotes 1
T5838 2489-2495 NN denotes Figure
T5837 2488-2489 -LRB- denotes (
T5836 2481-2487 NN denotes assays
T5835 2477-2480 NN denotes PCR
T5834 2467-2476 JJ denotes Real-time
T5833 2461-2466 NNP denotes Level
T5832 2445-2460 NNP denotes Transcriptional
T5831 2441-2444 DT denotes the
T5830 2438-2440 IN denotes at
T5829 2429-2437 NN denotes Promoter
T5828 2424-2428 NN denotes Gene
T5827 2421-2423 JJ denotes ɛy
T5826 2417-2420 DT denotes the
T5825 2407-2416 VB denotes Represses
T5824 2398-2406 RB denotes Directly
T5823 2393-2397 NN denotes Sox6
T5822 2388-2392 DT denotes That
T5821 2379-2387 NNP denotes Indicate
T5820 2373-2378 NNP denotes Cells
T5819 2367-2372 NN denotes GM979
T5818 2361-2366 VB denotes Using
T5817 2353-2360 NN denotes Studies
T5816 2340-2352 NN denotes Transfection
T4754 1245-1246 -RRB- denotes ]
T4753 1243-1245 CD denotes 14
T4752 1242-1243 -LRB- denotes [
T4751 1235-1241 NN denotes defect
T4750 1229-1234 NN denotes heart
T4749 1225-1228 DT denotes the
T4748 1220-1224 IN denotes from
T4747 1209-1219 RB denotes presumably
T4746 1208-1209 -LRB- denotes (
T4745 1203-1207 NN denotes mice
T4744 1196-1202 JJ denotes mutant
T4743 1193-1195 IN denotes of
T4742 1183-1192 NN denotes lethality
T4741 1173-1182 JJ denotes Perinatal
T4740 1170-1171 -RRB- denotes )
T4739 1169-1170 CD denotes 1
T4738 1162-1168 NN denotes Figure
T4737 1161-1162 -LRB- denotes (
T4736 1157-1160 NN denotes dpc
T4735 1152-1156 CD denotes 18.5
T4734 1149-1151 IN denotes at
T4733 1144-1148 NN denotes mice
T4732 1141-1143 JJ denotes WT
T4731 1138-1140 IN denotes in
T4730 1133-1137 IN denotes than
T4729 1128-1132 NN denotes mice
T4728 1117-1127 JJ denotes homozygous
T4727 1111-1116 NN denotes p100H
T4726 1108-1110 IN denotes in
T4725 1101-1107 JJ denotes higher
T4723 1087-1091 RB denotes also
T4722 1084-1086 VB denotes is
T4721 1077-1083 NN denotes globin
T4720 1075-1076 NN denotes β
T4719 1069-1074 JJ denotes adult
T4718 1066-1068 IN denotes of
T4717 1060-1065 NN denotes level
T4716 1049-1059 NN denotes expression
T4715 1045-1048 DT denotes the
T4714 1043-1044 -COMMA- denotes ,
T4713 1035-1043 RB denotes Moreover
T4712 1032-1033 -RRB- denotes )
T4711 1031-1032 CD denotes 1
T4710 1024-1030 NN denotes Figure
T4709 1023-1024 -LRB- denotes (
T4708 1019-1022 NN denotes dpc
T4707 1014-1018 CD denotes 18.5
T4706 1011-1013 IN denotes at
T4705 1004-1010 NN denotes globin
T4704 1001-1003 JJ denotes ɛy
T4703 997-1000 IN denotes for
T4702 992-996 VB denotes seen
T4701 987-991 IN denotes than
T4700 980-986 NN denotes extent
T4699 973-979 JJ denotes lesser
T4698 968-972 RB denotes much
T4697 966-967 DT denotes a
T4696 963-965 TO denotes to
T4695 959-962 CC denotes but
T4694 957-958 -COMMA- denotes ,
T4693 953-957 NN denotes mice
T4692 950-952 JJ denotes WT
T4691 945-949 IN denotes with
T4690 936-944 VB denotes compared
T4689 934-935 -COMMA- denotes ,
T4688 930-934 NN denotes mice
T4687 919-929 JJ denotes homozygous
T4686 913-918 NN denotes p100H
T4685 910-912 IN denotes in
T4684 903-909 JJ denotes higher
T4683 898-902 RB denotes also
T4682 894-897 VB denotes are
T4681 892-893 -RRB- denotes )
T4680 889-892 NN denotes βh1
T4679 885-888 CC denotes and
T4678 883-884 NN denotes ζ
T4677 882-883 -LRB- denotes (
T4676 876-881 NN denotes genes
T4675 869-875 NN denotes globin
T4674 859-868 JJ denotes embryonic
T4673 855-858 CD denotes two
T4672 849-854 JJ denotes other
T4671 845-848 DT denotes the
T4670 842-844 IN denotes of
T4669 835-841 NN denotes levels
T4668 824-834 NN denotes expression
T4667 820-823 DT denotes the
T4666 818-819 -COMMA- denotes ,
T4665 805-818 RB denotes Interestingly
T4664 802-803 -RRB- denotes )
T4663 798-802 NN denotes data
T4662 786-797 JJ denotes unpublished
T4661 785-786 -LRB- denotes (
T4660 780-784 NN denotes mice
T4659 767-779 JJ denotes heterozygous
T4658 763-766 CC denotes and
T4657 760-762 NN denotes WT
T4656 752-759 IN denotes between
T4655 747-751 VB denotes seen
T4654 743-746 VB denotes was
T4653 732-742 NN denotes difference
T4652 729-731 DT denotes No
T4651 723-727 NN denotes mice
T4650 720-722 JJ denotes WT
T4649 717-719 IN denotes in
T4648 708-716 VB denotes observed
T4647 697-707 NN denotes expression
T4646 694-696 IN denotes in
T4645 686-693 NN denotes decline
T4644 682-685 DT denotes the
T4643 679-681 TO denotes to
T4642 670-678 NN denotes contrast
T4641 667-669 IN denotes in
T4640 665-666 -COMMA- denotes ,
T4639 661-665 NN denotes mice
T4638 654-660 JJ denotes mutant
T4637 651-653 IN denotes in
T4636 644-650 NN denotes points
T4635 639-643 NN denotes time
T4634 634-638 DT denotes both
T4633 631-633 IN denotes at
T4632 624-630 NN denotes levels
T4631 619-623 JJ denotes high
T4630 616-618 IN denotes at
T4629 606-615 VB denotes expressed
T4628 603-605 VB denotes is
T4627 598-602 NN denotes gene
T4626 595-597 JJ denotes ɛy
T4625 591-594 DT denotes the
T4624 589-590 -COMMA- denotes ,
T4623 588-589 CD denotes 1
T4622 581-587 NN denotes Figure
T4621 578-580 IN denotes in
T4620 572-577 VB denotes shown
T4619 569-571 IN denotes As
T4618 564-567 NN denotes dpc
T4617 559-563 CD denotes 18.5
T4616 555-558 CC denotes and
T4615 551-554 NN denotes dpc
T4614 546-550 CD denotes 15.5
T4613 544-545 -COMMA- denotes ,
T4612 538-544 NN denotes stages
T4611 524-537 JJ denotes developmental
T4610 520-523 CD denotes two
T4609 517-519 IN denotes at
T4608 510-516 NN denotes livers
T4607 504-509 NN denotes mouse
T4606 501-503 JJ denotes WT
T4605 497-500 CC denotes and
T4604 490-496 NN denotes mutant
T4603 484-489 NN denotes p100H
T4602 481-483 IN denotes in
T4601 475-480 NN denotes genes
T4600 468-474 NN denotes globin
T4599 462-467 JJ denotes other
T4598 459-461 IN denotes of
T4597 452-458 NN denotes levels
T4596 441-451 NN denotes expression
T4595 437-440 DT denotes the
T4594 426-436 VB denotes quantitate
T4593 423-425 TO denotes to
T4592 418-422 VB denotes used
T4591 414-417 VB denotes was
T4590 410-413 NN denotes PCR
T4589 400-409 JJ denotes Real-time
T4588 397-398 -RRB- denotes )
T4587 393-397 NN denotes data
T4586 381-392 JJ denotes unpublished
T4585 380-381 -LRB- denotes (
T4584 378-379 -RRB- denotes )
T4583 375-378 NN denotes PCR
T4582 374-375 -LRB- denotes (
T4581 365-373 NN denotes reaction
T4580 359-364 NN denotes chain
T4579 348-358 NN denotes polymerase
T4578 338-347 JJ denotes real-time
T4577 332-337 VB denotes using
T4576 330-331 -RRB- denotes ]
T4575 328-330 CD denotes 13
T4574 327-328 -LRB- denotes [
T4573 322-326 NN denotes Sox6
T4572 319-321 IN denotes of
T4571 312-318 NN denotes allele
T4570 302-311 JJ denotes knock-out
T4569 290-301 JJ denotes independent
T4568 287-289 DT denotes an
T4567 284-286 IN denotes in
T4566 274-283 VB denotes confirmed
T4565 270-273 VB denotes was
T4564 258-269 NN denotes observation
T4563 250-257 JJ denotes initial
T4562 245-249 DT denotes This
T4561 236-243 NN denotes targets
T4560 225-235 JJ denotes downstream
T4559 220-224 NN denotes Sox6
T4558 211-219 VB denotes identify
T4557 208-210 TO denotes to
T4556 194-207 NN denotes hybridization
T4555 182-193 JJ denotes subtractive
T4554 176-181 VB denotes using
T4553 170-175 NN denotes mouse
T4552 163-169 NN denotes p 100H
T4551 159-162 DT denotes the
T4550 156-158 IN denotes in
T4549 145-155 NN denotes transcript
T4548 133-144 VB denotes upregulated
T4547 130-132 DT denotes an
T4546 127-129 IN denotes as
T4545 116-126 VB denotes identified
T4544 106-115 RB denotes initially
T4543 102-105 VB denotes was
T4542 97-101 NN denotes gene
T4541 90-96 NN denotes globin
T4540 87-89 JJ denotes ɛy
T4539 83-86 DT denotes The
T4875 1921-1925 NN denotes mice
T4874 1918-1920 JJ denotes WT
T4873 1907-1917 JJ denotes homozygous
T4872 1903-1906 NN denotes dpc
T4871 1898-1902 CD denotes 18.5
T4870 1894-1897 CC denotes and
T4869 1890-1893 NN denotes dpc
T4868 1885-1889 CD denotes 15.5
T4867 1882-1884 IN denotes of
T4866 1875-1881 NN denotes livers
T4865 1871-1874 DT denotes the
T4864 1868-1870 IN denotes in
T4863 1857-1867 NN denotes expression
T4862 1848-1856 NN denotes βmaj/min
T4861 1845-1847 IN denotes of
T4860 1839-1844 NN denotes level
T4859 1835-1838 DT denotes the
T4858 1832-1834 TO denotes to
T4857 1821-1831 JJ denotes equivalent
T4856 1807-1820 RB denotes statistically
T4855 1804-1806 VB denotes is
T4854 1799-1803 NN denotes mice
T4853 1792-1798 JJ denotes mutant
T4852 1781-1791 JJ denotes homozygous
T4851 1777-1780 NN denotes dpc
T4850 1772-1776 CD denotes 18.5
T4849 1768-1771 CC denotes and
T4848 1764-1767 NN denotes dpc
T4847 1759-1763 CD denotes 15.5
T4846 1756-1758 IN denotes of
T4845 1749-1755 NN denotes livers
T4844 1745-1748 DT denotes the
T4843 1742-1744 IN denotes in
T4842 1731-1741 NN denotes expression
T4841 1728-1730 JJ denotes ɛy
T4840 1725-1727 IN denotes of
T4839 1719-1724 NN denotes level
T4838 1715-1718 DT denotes the
T4837 1710-1714 IN denotes that
T4836 1705-1709 VB denotes note
T4835 1702-1704 PRP denotes We
T4834 1699-1700 -RRB- denotes ]
T4833 1697-1699 CD denotes 29
T4832 1696-1697 -LRB- denotes [
T4831 1691-1695 NN denotes mice
T4830 1685-1690 JJ denotes fetal
T4829 1682-1684 JJ denotes WT
T4828 1678-1681 IN denotes for
T4827 1670-1677 NN denotes results
T4826 1660-1669 VB denotes published
T4825 1649-1659 RB denotes previously
T4824 1644-1648 IN denotes with
T4823 1634-1643 NN denotes agreement
T4822 1631-1633 IN denotes in
T4821 1627-1630 VB denotes are
T4820 1623-1626 CC denotes and
T4819 1615-1622 NN denotes samples
T4818 1611-1614 DT denotes all
T4817 1604-1610 IN denotes across
T4816 1593-1603 JJ denotes comparable
T4815 1588-1592 RB denotes thus
T4814 1584-1587 VB denotes are
T4813 1580-1583 CC denotes and
T4812 1573-1579 NN denotes levels
T4811 1564-1572 JJ denotes relative
T4810 1560-1563 VB denotes are
T4809 1554-1559 VB denotes shown
T4808 1547-1553 NN denotes levels
T4807 1543-1546 DT denotes the
T4806 1541-1542 -COMMA- denotes ,
T4805 1534-1541 NN denotes control
T4804 1525-1533 JJ denotes internal
T4803 1520-1524 JJ denotes same
T4802 1516-1519 DT denotes the
T4801 1511-1515 IN denotes with
T4800 1506-1510 NN denotes time
T4799 1501-1505 JJ denotes same
T4798 1497-1500 DT denotes the
T4797 1494-1496 IN denotes at
T4796 1484-1493 VB denotes performed
T4795 1479-1483 VB denotes were
T4794 1472-1478 NN denotes assays
T4793 1468-1471 DT denotes the
T4792 1465-1467 IN denotes of
T4791 1461-1464 DT denotes all
T4790 1453-1460 IN denotes Because
T4789 1450-1451 -RRB- denotes )
T4788 1446-1450 NN denotes bars
T4787 1440-1445 NN denotes error
T4786 1437-1439 IN denotes by
T4785 1431-1436 VB denotes shown
T4784 1428-1430 VB denotes is
T4783 1423-1427 NN denotes data
T4782 1419-1422 DT denotes the
T4781 1416-1418 IN denotes of
T4780 1406-1415 NN denotes deviation
T4779 1397-1405 JJ denotes standard
T4778 1396-1397 -LRB- denotes (
T4777 1385-1395 NN denotes triplicate
T4776 1382-1384 IN denotes in
T4775 1372-1381 VB denotes performed
T4774 1367-1371 VB denotes were
T4773 1362-1366 WDT denotes that
T4772 1354-1361 NN denotes results
T4771 1350-1353 NN denotes PCR
T4770 1345-1349 NN denotes time
T4769 1340-1344 JJ denotes real
T4768 1329-1339 NN denotes illustrate
T4767 1327-1328 CD denotes 1
T4766 1320-1326 NN denotes Figure
T4765 1317-1319 IN denotes in
T4764 1310-1316 NN denotes graphs
T4763 1306-1309 DT denotes The
T4762 1294-1304 NN denotes expression
T4761 1287-1293 NN denotes globin
T4760 1277-1286 JJ denotes postnatal
T4759 1266-1276 VB denotes evaluating
T4758 1261-1265 IN denotes from
T4757 1258-1260 PRP denotes us
T4756 1248-1257 VB denotes precludes
T4755 1246-1247 -RRB- denotes )
T4538 78-82 NN denotes Mice
T4537 63-77 JJ denotes Sox6-Deficient
T4536 60-62 IN denotes in
T4535 58-59 -COMMA- denotes ,
T4534 56-58 NNP denotes ɛy
T4533 54-55 -COMMA- denotes ,
T4532 48-54 NNP denotes Globin
T4531 38-47 NNP denotes Embryonic
T4530 34-37 DT denotes the
T4529 31-33 IN denotes of
T4528 20-30 NN denotes Expression
T4527 9-19 JJ denotes Persistent
R3099 T4528 T4527 arg1Of Expression,Persistent
R3100 T4528 T4529 arg1Of Expression,of
R3101 T4528 T4535 arg1Of Expression,","
R3102 T4528 T4536 arg1Of Expression,in
R3103 T4532 T4529 arg2Of Globin,of
R3104 T4532 T4530 arg1Of Globin,the
R3105 T4532 T4531 arg1Of Globin,Embryonic
R3106 T4532 T4533 arg1Of Globin,","
R3107 T4534 T4533 arg2Of ɛy,","
R3108 T4538 T4536 arg2Of Mice,in
R3109 T4538 T4537 arg1Of Mice,Sox6-Deficient
R3110 T4542 T4539 arg1Of gene,The
R3111 T4542 T4540 arg1Of gene,ɛy
R3112 T4542 T4541 arg1Of gene,globin
R3113 T4542 T4543 arg1Of gene,was
R3114 T4542 T4545 arg2Of gene,identified
R3115 T4545 T4543 arg2Of identified,was
R3116 T4545 T4544 arg1Of identified,initially
R3117 T4545 T4546 arg1Of identified,as
R3118 T4549 T4546 arg2Of transcript,as
R3119 T4549 T4547 arg1Of transcript,an
R3120 T4549 T4548 arg2Of transcript,upregulated
R3121 T4549 T4550 arg1Of transcript,in
R3122 T4553 T4550 arg2Of mouse,in
R3123 T4553 T4551 arg1Of mouse,the
R3124 T4553 T4552 arg1Of mouse,p 100H
R3125 T4553 T4554 arg1Of mouse,using
R3126 T4554 T4557 modOf using,to
R3127 T4556 T4554 arg2Of hybridization,using
R3128 T4556 T4555 arg1Of hybridization,subtractive
R3129 T4558 T4557 arg1Of identify,to
R3130 T4561 T4558 arg2Of targets,identify
R3131 T4561 T4559 arg1Of targets,Sox6
R3132 T4561 T4560 arg1Of targets,downstream
R3133 T4564 T4562 arg1Of observation,This
R3134 T4564 T4563 arg1Of observation,initial
R3135 T4564 T4565 arg1Of observation,was
R3136 T4564 T4566 arg2Of observation,confirmed
R3137 T4566 T4565 arg2Of confirmed,was
R3138 T4566 T4567 arg1Of confirmed,in
R3139 T4566 T4574 arg1Of confirmed,[
R3140 T4571 T4567 arg2Of allele,in
R3141 T4571 T4568 arg1Of allele,an
R3142 T4571 T4569 arg1Of allele,independent
R3143 T4571 T4570 arg1Of allele,knock-out
R3144 T4571 T4572 arg1Of allele,of
R3145 T4573 T4572 arg2Of Sox6,of
R3146 T4575 T4574 arg2Of 13,[
R3147 T4576 T4574 arg3Of ],[
R3148 T4577 T4566 arg3Of using,confirmed
R3149 T4581 T4577 arg2Of reaction,using
R3150 T4581 T4578 arg1Of reaction,real-time
R3151 T4581 T4579 arg1Of reaction,polymerase
R3152 T4581 T4580 arg1Of reaction,chain
R3153 T4581 T4582 arg1Of reaction,(
R3154 T4581 T4585 arg1Of reaction,(
R3155 T4583 T4582 arg2Of PCR,(
R3156 T4584 T4582 arg3Of ),(
R3157 T4587 T4585 arg2Of data,(
R3158 T4587 T4586 arg1Of data,unpublished
R3159 T4588 T4585 arg3Of ),(
R3160 T4590 T4589 arg1Of PCR,Real-time
R3161 T4590 T4591 arg1Of PCR,was
R3162 T4590 T4592 arg2Of PCR,used
R3163 T4592 T4591 arg2Of used,was
R3164 T4594 T4592 arg3Of quantitate,used
R3165 T4594 T4593 arg1Of quantitate,to
R3166 T4594 T4609 arg1Of quantitate,at
R3167 T4597 T4594 arg2Of levels,quantitate
R3168 T4597 T4595 arg1Of levels,the
R3169 T4597 T4596 arg1Of levels,expression
R3170 T4597 T4598 arg1Of levels,of
R3171 T4601 T4598 arg2Of genes,of
R3172 T4601 T4599 arg1Of genes,other
R3173 T4601 T4600 arg1Of genes,globin
R3174 T4601 T4602 arg1Of genes,in
R3175 T4604 T4603 arg1Of mutant,p100H
R3176 T4604 T4605 arg1Of mutant,and
R3177 T4605 T4602 arg2Of and,in
R3178 T4608 T4605 arg2Of livers,and
R3179 T4608 T4606 arg1Of livers,WT
R3180 T4608 T4607 arg1Of livers,mouse
R3181 T4612 T4610 arg1Of stages,two
R3182 T4612 T4611 arg1Of stages,developmental
R3183 T4612 T4613 arg1Of stages,","
R3184 T4613 T4616 arg1Of ",",and
R3185 T4615 T4613 arg2Of dpc,","
R3186 T4615 T4614 arg1Of dpc,15.5
R3187 T4616 T4609 arg2Of and,at
R3188 T4618 T4616 arg2Of dpc,and
R3189 T4618 T4617 arg1Of dpc,18.5
R3190 T4620 T4619 arg2Of shown,As
R3191 T4620 T4621 arg1Of shown,in
R3192 T4622 T4621 arg2Of Figure,in
R3193 T4622 T4623 arg1Of Figure,1
R3194 T4627 T4625 arg1Of gene,the
R3195 T4627 T4626 arg1Of gene,ɛy
R3196 T4627 T4628 arg1Of gene,is
R3197 T4627 T4629 arg2Of gene,expressed
R3198 T4629 T4619 arg1Of expressed,As
R3199 T4629 T4624 arg1Of expressed,","
R3200 T4629 T4628 arg2Of expressed,is
R3201 T4629 T4630 arg1Of expressed,at
R3202 T4629 T4633 arg1Of expressed,at
R3203 T4629 T4637 arg1Of expressed,in
R3204 T4629 T4640 arg1Of expressed,","
R3205 T4629 T4641 arg1Of expressed,in
R3206 T4632 T4630 arg2Of levels,at
R3207 T4632 T4631 arg1Of levels,high
R3208 T4636 T4633 arg2Of points,at
R3209 T4636 T4634 arg1Of points,both
R3210 T4636 T4635 arg1Of points,time
R3211 T4639 T4637 arg2Of mice,in
R3212 T4639 T4638 arg1Of mice,mutant
R3213 T4641 T4643 arg1Of in,to
R3214 T4642 T4641 arg2Of contrast,in
R3215 T4645 T4641 arg3Of decline,in
R3216 T4645 T4644 arg1Of decline,the
R3217 T4645 T4646 arg1Of decline,in
R3218 T4647 T4646 arg2Of expression,in
R3219 T4647 T4648 arg2Of expression,observed
R3220 T4648 T4649 arg1Of observed,in
R3221 T4651 T4649 arg2Of mice,in
R3222 T4651 T4650 arg1Of mice,WT
R3223 T4653 T4652 arg1Of difference,No
R3224 T4653 T4654 arg1Of difference,was
R3225 T4653 T4655 arg2Of difference,seen
R3226 T4655 T4654 arg2Of seen,was
R3227 T4655 T4656 arg1Of seen,between
R3228 T4657 T4658 arg1Of WT,and
R3229 T4659 T4658 arg2Of heterozygous,and
R3230 T4660 T4656 arg2Of mice,between
R3231 T4660 T4657 arg1Of mice,WT
R3232 T4660 T4659 arg1Of mice,heterozygous
R3233 T4660 T4661 arg1Of mice,(
R3234 T4663 T4661 arg2Of data,(
R3235 T4663 T4662 arg1Of data,unpublished
R3236 T4664 T4661 arg3Of ),(
R3237 T4669 T4667 arg1Of levels,the
R3238 T4669 T4668 arg1Of levels,expression
R3239 T4669 T4670 arg1Of levels,of
R3240 T4669 T4682 arg1Of levels,are
R3241 T4669 T4684 arg1Of levels,higher
R3242 T4676 T4670 arg2Of genes,of
R3243 T4676 T4671 arg1Of genes,the
R3244 T4676 T4672 arg1Of genes,other
R3245 T4676 T4673 arg1Of genes,two
R3246 T4676 T4674 arg1Of genes,embryonic
R3247 T4676 T4675 arg1Of genes,globin
R3248 T4676 T4677 arg1Of genes,(
R3249 T4678 T4679 arg1Of ζ,and
R3250 T4679 T4677 arg2Of and,(
R3251 T4680 T4679 arg2Of βh1,and
R3252 T4681 T4677 arg3Of ),(
R3253 T4682 T4665 arg1Of are,Interestingly
R3254 T4682 T4666 arg1Of are,","
R3255 T4682 T4683 arg1Of are,also
R3256 T4682 T4689 arg1Of are,","
R3257 T4682 T4690 arg1Of are,compared
R3258 T4684 T4682 arg2Of higher,are
R3259 T4684 T4685 arg1Of higher,in
R3260 T4688 T4685 arg2Of mice,in
R3261 T4688 T4686 arg1Of mice,p100H
R3262 T4688 T4687 arg1Of mice,homozygous
R3263 T4691 T4695 arg1Of with,but
R3264 T4693 T4691 arg2Of mice,with
R3265 T4693 T4692 arg1Of mice,WT
R3266 T4695 T4690 arg2Of but,compared
R3267 T4695 T4694 arg1Of but,","
R3268 T4696 T4695 arg2Of to,but
R3269 T4699 T4698 arg1Of lesser,much
R3270 T4700 T4696 arg2Of extent,to
R3271 T4700 T4697 arg1Of extent,a
R3272 T4700 T4699 arg1Of extent,lesser
R3273 T4700 T4701 arg1Of extent,than
R3274 T4702 T4701 arg2Of seen,than
R3275 T4702 T4703 arg1Of seen,for
R3276 T4702 T4706 arg1Of seen,at
R3277 T4705 T4703 arg2Of globin,for
R3278 T4705 T4704 arg1Of globin,ɛy
R3279 T4708 T4706 arg2Of dpc,at
R3280 T4708 T4707 arg1Of dpc,18.5
R3281 T4708 T4709 arg1Of dpc,(
R3282 T4710 T4709 arg2Of Figure,(
R3283 T4710 T4711 arg1Of Figure,1
R3284 T4712 T4709 arg3Of ),(
R3285 T4717 T4715 arg1Of level,the
R3286 T4717 T4716 arg1Of level,expression
R3287 T4717 T4718 arg1Of level,of
R3288 T4717 T4722 arg1Of level,is
R3289 T4717 T4725 arg1Of level,higher
R3290 T4721 T4718 arg2Of globin,of
R3291 T4721 T4719 arg1Of globin,adult
R3292 T4721 T4720 arg1Of globin,β
R3293 T4722 T4713 arg1Of is,Moreover
R3294 T4722 T4714 arg1Of is,","
R3295 T4722 T4723 arg1Of is,also
R3296 T4722 T4734 arg1Of is,at
R3297 T4725 T4722 arg2Of higher,is
R3298 T4725 T4724 arg1Of higher,somewhat
R3299 T4725 T4726 arg1Of higher,in
R3300 T4725 T4730 arg1Of higher,than
R3301 T4729 T4726 arg2Of mice,in
R3302 T4729 T4727 arg1Of mice,p100H
R3303 T4729 T4728 arg1Of mice,homozygous
R3304 T4731 T4730 arg2Of in,than
R3305 T4733 T4731 arg2Of mice,in
R3306 T4733 T4732 arg1Of mice,WT
R3307 T4736 T4734 arg2Of dpc,at
R3308 T4736 T4735 arg1Of dpc,18.5
R3309 T4736 T4737 arg1Of dpc,(
R3310 T4738 T4737 arg2Of Figure,(
R3311 T4738 T4739 arg1Of Figure,1
R3312 T4740 T4737 arg3Of ),(
R3313 T4742 T4741 arg1Of lethality,Perinatal
R3314 T4742 T4743 arg1Of lethality,of
R3315 T4742 T4746 arg1Of lethality,(
R3316 T4742 T4756 arg1Of lethality,precludes
R3317 T4745 T4743 arg2Of mice,of
R3318 T4745 T4744 arg1Of mice,mutant
R3319 T4748 T4746 arg2Of from,(
R3320 T4748 T4747 arg1Of from,presumably
R3321 T4751 T4748 arg2Of defect,from
R3322 T4751 T4749 arg1Of defect,the
R3323 T4751 T4750 arg1Of defect,heart
R3324 T4751 T4752 arg1Of defect,[
R3325 T4753 T4752 arg2Of 14,[
R3326 T4754 T4752 arg3Of ],[
R3327 T4755 T4746 arg3Of ),(
R3328 T4756 T4758 arg1Of precludes,from
R3329 T4757 T4756 arg2Of us,precludes
R3330 T4759 T4758 arg2Of evaluating,from
R3331 T4762 T4759 arg2Of expression,evaluating
R3332 T4762 T4760 arg1Of expression,postnatal
R3333 T4762 T4761 arg1Of expression,globin
R3334 T4764 T4763 arg1Of graphs,The
R3335 T4764 T4765 arg1Of graphs,in
R3336 T4764 T4773 arg1Of graphs,that
R3337 T4764 T4774 arg1Of graphs,were
R3338 T4764 T4775 arg2Of graphs,performed
R3339 T4772 T4765 arg2Of results,in
R3340 T4772 T4766 arg1Of results,Figure
R3341 T4772 T4767 arg1Of results,1
R3342 T4772 T4768 arg1Of results,illustrate
R3343 T4772 T4769 arg1Of results,real
R3344 T4772 T4770 arg1Of results,time
R3345 T4772 T4771 arg1Of results,PCR
R3346 T4775 T4774 arg2Of performed,were
R3347 T4775 T4776 arg1Of performed,in
R3348 T4777 T4776 arg2Of triplicate,in
R3349 T4777 T4778 arg1Of triplicate,(
R3350 T4780 T4779 arg1Of deviation,standard
R3351 T4780 T4781 arg1Of deviation,of
R3352 T4780 T4784 arg1Of deviation,is
R3353 T4780 T4785 arg2Of deviation,shown
R3354 T4783 T4781 arg2Of data,of
R3355 T4783 T4782 arg1Of data,the
R3356 T4785 T4778 arg2Of shown,(
R3357 T4785 T4784 arg2Of shown,is
R3358 T4788 T4785 arg1Of bars,shown
R3359 T4788 T4786 arg2Of bars,by
R3360 T4788 T4787 arg1Of bars,error
R3361 T4789 T4778 arg3Of ),(
R3362 T4791 T4792 arg1Of all,of
R3363 T4791 T4795 arg1Of all,were
R3364 T4791 T4796 arg2Of all,performed
R3365 T4794 T4792 arg2Of assays,of
R3366 T4794 T4793 arg1Of assays,the
R3367 T4796 T4790 arg2Of performed,Because
R3368 T4796 T4795 arg2Of performed,were
R3369 T4796 T4797 arg1Of performed,at
R3370 T4800 T4797 arg2Of time,at
R3371 T4800 T4798 arg1Of time,the
R3372 T4800 T4799 arg1Of time,same
R3373 T4800 T4801 arg1Of time,with
R3374 T4805 T4801 arg2Of control,with
R3375 T4805 T4802 arg1Of control,the
R3376 T4805 T4803 arg1Of control,same
R3377 T4805 T4804 arg1Of control,internal
R3378 T4808 T4807 arg1Of levels,the
R3379 T4808 T4809 arg2Of levels,shown
R3380 T4808 T4810 arg1Of levels,are
R3381 T4808 T4814 arg1Of levels,are
R3382 T4808 T4816 arg1Of levels,comparable
R3383 T4808 T4821 arg1Of levels,are
R3384 T4808 T4822 arg1Of levels,in
R3385 T4810 T4813 arg1Of are,and
R3386 T4812 T4810 arg2Of levels,are
R3387 T4812 T4811 arg1Of levels,relative
R3388 T4813 T4790 arg1Of and,Because
R3389 T4813 T4806 arg1Of and,","
R3390 T4814 T4815 arg1Of are,thus
R3391 T4814 T4817 arg1Of are,across
R3392 T4814 T4820 arg1Of are,and
R3393 T4816 T4814 arg2Of comparable,are
R3394 T4819 T4817 arg2Of samples,across
R3395 T4819 T4818 arg1Of samples,all
R3396 T4820 T4813 arg2Of and,and
R3397 T4821 T4820 arg2Of are,and
R3398 T4822 T4821 arg2Of in,are
R3399 T4823 T4822 arg2Of agreement,in
R3400 T4823 T4824 arg1Of agreement,with
R3401 T4826 T4825 arg1Of published,previously
R3402 T4827 T4824 arg2Of results,with
R3403 T4827 T4826 arg1Of results,published
R3404 T4827 T4828 arg1Of results,for
R3405 T4831 T4828 arg2Of mice,for
R3406 T4831 T4829 arg1Of mice,WT
R3407 T4831 T4830 arg1Of mice,fetal
R3408 T4831 T4832 arg1Of mice,[
R3409 T4833 T4832 arg2Of 29,[
R3410 T4834 T4832 arg3Of ],[
R3411 T4835 T4836 arg1Of We,note
R3412 T4839 T4838 arg1Of level,the
R3413 T4839 T4840 arg1Of level,of
R3414 T4839 T4855 arg1Of level,is
R3415 T4839 T4857 arg1Of level,equivalent
R3416 T4842 T4840 arg2Of expression,of
R3417 T4842 T4841 arg1Of expression,ɛy
R3418 T4842 T4843 arg1Of expression,in
R3419 T4845 T4843 arg2Of livers,in
R3420 T4845 T4844 arg1Of livers,the
R3421 T4845 T4846 arg1Of livers,of
R3422 T4848 T4847 arg1Of dpc,15.5
R3423 T4848 T4849 arg1Of dpc,and
R3424 T4849 T4846 arg2Of and,of
R3425 T4854 T4849 arg2Of mice,and
R3426 T4854 T4850 arg1Of mice,18.5
R3427 T4854 T4851 arg1Of mice,dpc
R3428 T4854 T4852 arg1Of mice,homozygous
R3429 T4854 T4853 arg1Of mice,mutant
R3430 T4855 T4836 arg2Of is,note
R3431 T4855 T4837 arg1Of is,that
R3432 T4857 T4855 arg2Of equivalent,is
R3433 T4857 T4856 arg1Of equivalent,statistically
R3434 T4857 T4858 arg1Of equivalent,to
R3435 T4860 T4858 arg2Of level,to
R3436 T4860 T4859 arg1Of level,the
R3437 T4860 T4861 arg1Of level,of
R3438 T4863 T4861 arg2Of expression,of
R3439 T4863 T4862 arg1Of expression,βmaj/min
R3440 T4863 T4864 arg1Of expression,in
R3441 T4866 T4864 arg2Of livers,in
R3442 T4866 T4865 arg1Of livers,the
R3443 T4866 T4867 arg1Of livers,of
R3444 T4869 T4868 arg1Of dpc,15.5
R3445 T4869 T4870 arg1Of dpc,and
R3446 T4870 T4867 arg2Of and,of
R3447 T4875 T4870 arg2Of mice,and
R3448 T4875 T4871 arg1Of mice,18.5
R3449 T4875 T4872 arg1Of mice,dpc
R3450 T4875 T4873 arg1Of mice,homozygous
R3451 T4875 T4874 arg1Of mice,WT
R3966 T5817 T5816 arg1Of Studies,Transfection
R3967 T5817 T5818 arg1Of Studies,Using
R3968 T5817 T5825 arg1Of Studies,Represses
R3969 T5821 T5819 arg1Of Indicate,GM979
R3970 T5821 T5820 arg1Of Indicate,Cells
R3971 T5823 T5818 arg2Of Sox6,Using
R3972 T5823 T5821 arg1Of Sox6,Indicate
R3973 T5823 T5822 arg1Of Sox6,That
R3974 T5825 T5824 arg1Of Represses,Directly
R3975 T5829 T5825 arg2Of Promoter,Represses
R3976 T5829 T5826 arg1Of Promoter,the
R3977 T5829 T5827 arg1Of Promoter,ɛy
R3978 T5829 T5828 arg1Of Promoter,Gene
R3979 T5829 T5830 arg1Of Promoter,at
R3980 T5833 T5830 arg2Of Level,at
R3981 T5833 T5831 arg1Of Level,the
R3982 T5833 T5832 arg1Of Level,Transcriptional
R3983 T5838 T5837 arg2Of Figure,(
R3984 T5838 T5839 arg1Of Figure,1
R3985 T5840 T5837 arg3Of ),(
R3986 T5843 T5834 arg1Of levels,Real-time
R3987 T5843 T5835 arg1Of levels,PCR
R3988 T5843 T5836 arg1Of levels,assays
R3989 T5843 T5837 arg1Of levels,(
R3990 T5843 T5841 arg1Of levels,measure
R3991 T5843 T5842 arg1Of levels,steady-state
R3992 T5843 T5844 arg1Of levels,of
R3993 T5846 T5844 arg2Of mRNA,of
R3994 T5846 T5845 arg1Of mRNA,ɛy
R3995 T5846 T5847 arg1Of mRNA,","
R3996 T5850 T5847 arg2Of activity,","
R3997 T5850 T5848 arg1Of activity,not
R3998 T5850 T5849 arg1Of activity,transcriptional
R3999 T5850 T5851 arg1Of activity,of
R4000 T5854 T5851 arg2Of promoter,of
R4001 T5854 T5852 arg1Of promoter,the
R4002 T5854 T5853 arg1Of promoter,ɛy
R4003 T5856 T5855 arg1Of investigate,To
R4004 T5858 T5860 arg1Of Sox6,acts
R4005 T5860 T5856 arg2Of acts,investigate
R4006 T5860 T5857 arg1Of acts,whether
R4007 T5860 T5859 arg1Of acts,directly
R4008 T5860 T5861 arg1Of acts,on
R4009 T5860 T5866 arg1Of acts,at
R4010 T5865 T5861 arg2Of promoter,on
R4011 T5865 T5862 arg1Of promoter,the
R4012 T5865 T5863 arg1Of promoter,ɛy
R4013 T5865 T5864 arg1Of promoter,gene
R4014 T5869 T5866 arg2Of level,at
R4015 T5869 T5867 arg1Of level,the
R4016 T5869 T5868 arg1Of level,transcriptional
R4017 T5871 T5856 arg1Of we,investigate
R4018 T5871 T5872 arg1Of we,used
R4019 T5872 T5855 modOf used,To
R4020 T5872 T5870 arg1Of used,","
R4021 T5875 T5874 arg1Of vitro,in
R4022 T5876 T5875 arg1Of transient,vitro
R4023 T5878 T5873 arg1Of assay,an
R4024 T5878 T5876 arg1Of assay,transient
R4025 T5878 T5877 arg1Of assay,transfection
R4026 T5878 T5879 arg1Of assay,and
R4027 T5879 T5872 arg2Of and,used
R4028 T5881 T5879 arg2Of cells,and
R4029 T5881 T5880 arg1Of cells,GM979
R4030 T5881 T5882 arg1Of cells,","
R4031 T5887 T5882 arg2Of line,","
R4032 T5887 T5883 arg1Of line,a
R4033 T5887 T5884 arg1Of line,murine
R4034 T5887 T5885 arg1Of line,erythroleukemic
R4035 T5887 T5886 arg1Of line,cell
R4036 T5887 T5888 arg1Of line,that
R4037 T5887 T5889 arg1Of line,expresses
R4038 T5891 T5892 arg1Of ɛy,and
R4039 T5893 T5892 arg2Of adult,and
R4040 T5895 T5889 arg2Of globins,expresses
R4041 T5895 T5890 arg1Of globins,both
R4042 T5895 T5891 arg1Of globins,ɛy
R4043 T5895 T5893 arg1Of globins,adult
R4044 T5895 T5894 arg1Of globins,beta
R4045 T5895 T5896 arg1Of globins,[
R4046 T5897 T5896 arg2Of 30,[
R4047 T5898 T5896 arg3Of ],[
R4048 T5899 T5900 arg1Of We,generated
R4049 T5899 T5910 arg1Of We,fusing
R4050 T5900 T5909 arg1Of generated,by
R4051 T5900 T5940 arg1Of generated,","
R4052 T5900 T5941 arg1Of generated,as
R4053 T5905 T5900 arg2Of construct,generated
R4054 T5905 T5901 arg1Of construct,an
R4055 T5905 T5902 arg1Of construct,ɛy
R4056 T5905 T5903 arg1Of construct,promoter
R4057 T5905 T5904 arg1Of construct,reporter
R4058 T5905 T5906 arg1Of construct,(
R4059 T5907 T5906 arg2Of E-Luc,(
R4060 T5908 T5906 arg3Of ),(
R4061 T5910 T5909 arg2Of fusing,by
R4062 T5910 T5933 arg1Of fusing,","
R4063 T5910 T5934 modOf fusing,followed
R4064 T5914 T5913 arg2Of μLCR,(
R4065 T5915 T5913 arg3Of ),(
R4066 T5916 T5910 arg2Of element,fusing
R4067 T5916 T5911 arg1Of element,a
R4068 T5916 T5912 arg1Of element,micro-LCR
R4069 T5916 T5913 arg1Of element,(
R4070 T5916 T5917 arg1Of element,(
R4071 T5916 T5921 arg1Of element,[
R4072 T5916 T5924 arg1Of element,to
R4073 T5919 T5917 arg2Of kb,(
R4074 T5919 T5918 arg1Of kb,2.5
R4075 T5920 T5917 arg3Of ),(
R4076 T5922 T5921 arg2Of 31,[
R4077 T5923 T5921 arg3Of ],[
R4078 T5928 T5924 arg2Of promoter,to
R4079 T5928 T5925 arg1Of promoter,the
R4080 T5928 T5926 arg1Of promoter,ɛy
R4081 T5928 T5927 arg1Of promoter,proximal
R4082 T5928 T5929 arg1Of promoter,(
R4083 T5931 T5929 arg2Of kb,(
R4084 T5931 T5930 arg1Of kb,2.2
R4085 T5932 T5929 arg3Of ),(
R4086 T5939 T5934 arg1Of gene,followed
R4087 T5939 T5935 arg2Of gene,by
R4088 T5939 T5936 arg1Of gene,the
R4089 T5939 T5937 arg1Of gene,luciferase
R4090 T5939 T5938 arg1Of gene,reporter
R4091 T5942 T5941 arg2Of shown,as
R4092 T5942 T5943 arg1Of shown,in
R4093 T5945 T5943 arg2Of 2A,in
R4094 T5945 T5944 arg1Of 2A,Figure
R4095 T5945 T5946 arg1Of 2A,(
R4096 T5947 T5946 arg2Of detailed,(
R4097 T5947 T5948 arg1Of detailed,in
R4098 T5949 T5950 arg1Of Materials,and
R4099 T5950 T5948 arg2Of and,in
R4100 T5951 T5950 arg2Of Methods,and
R4101 T5952 T5946 arg3Of ),(
R4102 T5953 T5954 arg1Of Overexpression,of
R4103 T5953 T5956 arg1Of Overexpression,in
R4104 T5953 T5959 arg1Of Overexpression,by
R4105 T5953 T5962 arg1Of Overexpression,leads
R4106 T5955 T5954 arg2Of Sox6,of
R4107 T5958 T5956 arg2Of cells,in
R4108 T5958 T5957 arg1Of cells,GM979
R4109 T5961 T5959 arg2Of transfection,by
R4110 T5961 T5960 arg1Of transfection,transient
R4111 T5962 T5963 arg1Of leads,to
R4112 T5966 T5963 arg2Of repression,to
R4113 T5966 T5964 arg1Of repression,a
R4114 T5966 T5965 arg1Of repression,dosage-dependent
R4115 T5966 T5967 arg1Of repression,of
R4116 T5970 T5967 arg2Of activity,of
R4117 T5970 T5968 arg1Of activity,E-Luc
R4118 T5970 T5969 arg1Of activity,reporter
R4119 T5970 T5971 arg1Of activity,(
R4120 T5973 T5971 arg2Of 2B,(
R4121 T5973 T5972 arg1Of 2B,Figure
R4122 T5974 T5971 arg3Of ),(
R4123 T5976 T5975 arg2Of contrast,In
R4124 T5978 T5979 arg1Of overexpression,of
R4125 T5978 T6000 arg1Of overexpression,fails
R4126 T5978 T6002 arg1Of overexpression,repress
R4127 T5983 T5979 arg2Of protein,of
R4128 T5983 T5980 arg1Of protein,a
R4129 T5983 T5981 arg2Of protein,truncated
R4130 T5983 T5982 arg1Of protein,Sox6
R4131 T5983 T5984 arg1Of protein,that
R4132 T5983 T5985 arg1Of protein,lacks
R4133 T5983 T5992 arg1Of protein,(
R4134 T5985 T5989 arg1Of lacks,[
R4135 T5988 T5985 arg2Of domain,lacks
R4136 T5988 T5986 arg1Of domain,its
R4137 T5988 T5987 arg1Of domain,HMG
R4138 T5990 T5989 arg2Of 32,[
R4139 T5991 T5989 arg3Of ],[
R4140 T5993 T5992 arg2Of similar,(
R4141 T5993 T5994 arg1Of similar,to
R4142 T5998 T5994 arg2Of allele,to
R4143 T5998 T5995 arg1Of allele,the
R4144 T5998 T5996 arg1Of allele,p 100H
R4145 T5998 T5997 arg1Of allele,mouse
R4146 T5999 T5992 arg3Of ),(
R4147 T6000 T5975 arg1Of fails,In
R4148 T6000 T5977 arg1Of fails,","
R4149 T6002 T6000 arg2Of repress,fails
R4150 T6002 T6001 arg1Of repress,to
R4151 T6004 T6002 arg2Of activity,repress
R4152 T6004 T6003 arg1Of activity,E-Luc
R4153 T6004 T6005 arg1Of activity,(
R4154 T6007 T6005 arg2Of 2B,(
R4155 T6007 T6006 arg1Of 2B,Figure
R4156 T6008 T6005 arg3Of ),(
R4157 T6010 T6009 arg1Of data,These
R4158 T6010 T6011 arg1Of data,indicate
R4159 T6013 T6014 arg1Of Sox6,acts
R4160 T6013 T6016 arg1Of Sox6,repress
R4161 T6014 T6011 arg2Of acts,indicate
R4162 T6014 T6012 arg1Of acts,that
R4163 T6016 T6014 arg2Of repress,acts
R4164 T6016 T6015 arg1Of repress,to
R4165 T6016 T6020 arg1Of repress,at
R4166 T6019 T6016 arg2Of promoter,repress
R4167 T6019 T6017 arg1Of promoter,the
R4168 T6019 T6018 arg1Of promoter,ɛy
R4169 T6023 T6020 arg2Of level,at
R4170 T6023 T6021 arg1Of level,the
R4171 T6023 T6022 arg1Of level,transcriptional
R4172 T6024 T6025 arg1Of Sox6,has
R4173 T6024 T6026 arg1Of Sox6,been
R4174 T6024 T6027 arg2Of Sox6,shown
R4175 T6024 T6029 arg1Of Sox6,act
R4176 T6024 T6035 arg1Of Sox6,interact
R4177 T6027 T6025 arg2Of shown,has
R4178 T6027 T6026 arg2Of shown,been
R4179 T6027 T6048 arg1Of shown,[
R4180 T6029 T6028 arg1Of act,to
R4181 T6029 T6030 arg1Of act,as
R4182 T6029 T6033 arg1Of act,and
R4183 T6032 T6030 arg2Of repressor,as
R4184 T6032 T6031 arg1Of repressor,a
R4185 T6033 T6027 arg3Of and,shown
R4186 T6035 T6033 arg2Of interact,and
R4187 T6035 T6034 arg1Of interact,to
R4188 T6035 T6036 arg1Of interact,with
R4189 T6039 T6038 arg1Of expressed,widely
R4190 T6040 T6036 arg2Of co-repressor,with
R4191 T6040 T6037 arg1Of co-repressor,a
R4192 T6040 T6039 arg1Of co-repressor,expressed
R4193 T6040 T6041 arg1Of co-repressor,","
R4194 T6040 T6043 arg1Of co-repressor,","
R4195 T6040 T6044 arg1Of co-repressor,on
R4196 T6042 T6041 arg2Of CtBP2,","
R4197 T6047 T6044 arg2Of promoter,on
R4198 T6047 T6045 arg1Of promoter,the
R4199 T6047 T6046 arg1Of promoter,fgf-3
R4200 T6049 T6048 arg2Of 5,[
R4201 T6050 T6048 arg3Of ],[
R4202 T6051 T6052 arg1Of CtBP2,is
R4203 T6051 T6053 arg2Of CtBP2,expressed
R4204 T6053 T6052 arg2Of expressed,is
R4205 T6053 T6054 arg1Of expressed,in
R4206 T6056 T6054 arg2Of cells,in
R4207 T6056 T6055 arg1Of cells,GM979
R4208 T6056 T6057 arg1Of cells,(
R4209 T6059 T6057 arg2Of data,(
R4210 T6059 T6058 arg1Of data,unpublished
R4211 T6060 T6057 arg3Of ),(
R4212 T6062 T6061 arg1Of investigate,To
R4213 T6065 T6064 arg1Of interaction,the
R4214 T6065 T6066 arg1Of interaction,with
R4215 T6065 T6068 arg1Of interaction,is
R4216 T6065 T6069 arg2Of interaction,required
R4217 T6067 T6066 arg2Of CtBP2,with
R4218 T6069 T6062 arg2Of required,investigate
R4219 T6069 T6063 arg1Of required,whether
R4220 T6069 T6068 arg2Of required,is
R4221 T6069 T6070 arg1Of required,for
R4222 T6072 T6070 arg2Of repression,for
R4223 T6072 T6071 arg1Of repression,Sox6
R4224 T6072 T6073 arg1Of repression,of
R4225 T6076 T6073 arg2Of promoter,of
R4226 T6076 T6074 arg1Of promoter,the
R4227 T6076 T6075 arg1Of promoter,ɛy
R4228 T6078 T6062 arg1Of we,investigate
R4229 T6078 T6079 arg1Of we,introduced
R4230 T6079 T6061 modOf introduced,To
R4231 T6079 T6077 arg1Of introduced,","
R4232 T6082 T6079 arg2Of mutation,introduced
R4233 T6082 T6080 arg1Of mutation,a
R4234 T6082 T6081 arg1Of mutation,point
R4235 T6082 T6083 arg1Of mutation,(
R4236 T6082 T6086 arg1Of mutation,in
R4237 T6084 T6083 arg2Of L386H,(
R4238 T6085 T6083 arg3Of ),(
R4239 T6089 T6086 arg2Of protein,in
R4240 T6089 T6087 arg1Of protein,the
R4241 T6089 T6088 arg1Of protein,Sox6
R4242 T6089 T6090 arg1Of protein,that
R4243 T6089 T6091 arg1Of protein,has
R4244 T6089 T6092 arg1Of protein,been
R4245 T6089 T6094 arg2Of protein,reported
R4246 T6089 T6096 arg1Of protein,be
R4247 T6089 T6097 arg1Of protein,sufficient
R4248 T6094 T6091 arg2Of reported,has
R4249 T6094 T6092 arg2Of reported,been
R4250 T6094 T6093 arg1Of reported,previously
R4251 T6096 T6094 arg3Of be,reported
R4252 T6096 T6095 arg1Of be,to
R4253 T6097 T6096 arg2Of sufficient,be
R4254 T6099 T6097 arg2Of abolish,sufficient
R4255 T6099 T6098 arg1Of abolish,to
R4256 T6101 T6099 arg2Of interaction,abolish
R4257 T6101 T6100 arg1Of interaction,Sox6-CtBP2
R4258 T6101 T6102 arg1Of interaction,[
R4259 T6103 T6102 arg2Of 5,[
R4260 T6104 T6102 arg3Of ],[
R4261 T6108 T6105 arg1Of change,This
R4262 T6108 T6106 arg1Of change,amino
R4263 T6108 T6107 arg1Of change,acid
R4264 T6108 T6109 arg1Of change,is
R4265 T6108 T6111 arg1Of change,in
R4266 T6109 T6110 arg1Of is,not
R4267 T6111 T6109 arg2Of in,is
R4268 T6116 T6111 arg2Of domain,in
R4269 T6116 T6112 arg1Of domain,the
R4270 T6116 T6113 arg1Of domain,HMG
R4271 T6116 T6114 arg1Of domain,DNA
R4272 T6116 T6115 arg1Of domain,binding
R4273 T6121 T6119 arg1Of version,this
R4274 T6121 T6120 arg1Of version,mutant
R4275 T6121 T6122 arg1Of version,of
R4276 T6121 T6124 arg1Of version,retains
R4277 T6123 T6122 arg2Of Sox6,of
R4278 T6124 T6117 arg1Of retains,However
R4279 T6124 T6118 arg1Of retains,","
R4280 T6124 T6140 arg1Of retains,","
R4281 T6124 T6141 modOf retains,indicating
R4282 T6126 T6124 arg2Of ability,retains
R4283 T6126 T6125 arg1Of ability,the
R4284 T6126 T6127 modOf ability,to
R4285 T6128 T6127 arg1Of repress,to
R4286 T6131 T6128 arg2Of promoter,repress
R4287 T6131 T6129 arg1Of promoter,the
R4288 T6131 T6130 arg1Of promoter,ɛy
R4289 T6131 T6132 arg1Of promoter,in
R4290 T6135 T6132 arg2Of assay,in
R4291 T6135 T6133 arg1Of assay,the
R4292 T6135 T6134 arg1Of assay,transfection
R4293 T6135 T6136 arg1Of assay,(
R4294 T6138 T6136 arg2Of 2B,(
R4295 T6138 T6137 arg1Of 2B,Figure
R4296 T6139 T6136 arg3Of ),(
R4297 T6143 T6144 arg1Of Sox6,represses
R4298 T6144 T6141 arg2Of represses,indicating
R4299 T6144 T6142 arg1Of represses,that
R4300 T6144 T6148 arg1Of represses,in
R4301 T6147 T6144 arg2Of promoter,represses
R4302 T6147 T6145 arg1Of promoter,the
R4303 T6147 T6146 arg1Of promoter,ɛy
R4304 T6151 T6148 arg2Of manner,in
R4305 T6151 T6149 arg1Of manner,a
R4306 T6151 T6150 arg1Of manner,CtBP2-independent
R4307 T6153 T6152 arg1Of analysis,Deletion
R4308 T6153 T6154 arg1Of analysis,of
R4309 T6153 T6165 arg1Of analysis,defined
R4310 T6157 T6154 arg2Of promoter,of
R4311 T6157 T6155 arg1Of promoter,the
R4312 T6157 T6156 arg1Of promoter,ɛy
R4313 T6160 T6159 arg2Of shown,as
R4314 T6160 T6161 arg1Of shown,in
R4315 T6163 T6161 arg2Of 2C,in
R4316 T6163 T6162 arg1Of 2C,Figure
R4317 T6165 T6158 arg1Of defined,","
R4318 T6165 T6159 arg1Of defined,as
R4319 T6165 T6164 arg1Of defined,","
R4320 T6167 T6165 arg2Of region,defined
R4321 T6167 T6166 arg1Of region,a
R4322 T6167 T6168 arg1Of region,(
R4323 T6167 T6173 arg1Of region,within
R4324 T6171 T6168 arg2Of −37,(
R4325 T6171 T6169 arg1Of −37,−63
R4326 T6171 T6170 arg1Of −37,to
R4327 T6172 T6168 arg3Of ),(
R4328 T6177 T6173 arg2Of promoter,within
R4329 T6177 T6174 arg1Of promoter,the
R4330 T6177 T6175 arg1Of promoter,ɛy
R4331 T6177 T6176 arg1Of promoter,proximal
R4332 T6177 T6178 arg1Of promoter,that
R4333 T6177 T6179 arg1Of promoter,is
R4334 T6177 T6180 arg1Of promoter,critical
R4335 T6180 T6179 arg2Of critical,is
R4336 T6180 T6181 arg1Of critical,for
R4337 T6183 T6181 arg2Of repression,for
R4338 T6183 T6182 arg1Of repression,Sox6
R4339 T6184 T6185 arg1Of Analysis,of
R4340 T6184 T6189 arg1Of Analysis,reveals
R4341 T6188 T6185 arg2Of region,of
R4342 T6188 T6186 arg1Of region,this
R4343 T6188 T6187 arg1Of region,short
R4344 T6194 T6189 arg2Of sites,reveals
R4345 T6194 T6190 arg1Of sites,two
R4346 T6194 T6191 arg1Of sites,Sox/Sox6
R4347 T6194 T6192 arg1Of sites,consensus
R4348 T6194 T6193 arg1Of sites,binding
R4349 T6194 T6195 arg1Of sites,[
R4350 T6194 T6198 arg1Of sites,(
R4351 T6196 T6195 arg2Of 5,[
R4352 T6197 T6195 arg3Of ],[
R4353 T6200 T6198 arg2Of 3A,(
R4354 T6200 T6199 arg1Of 3A,Figure
R4355 T6201 T6198 arg3Of ),(
R5002 T7433 T7434 arg1Of EMSA,and
R5003 T7434 T7441 arg1Of and,Binds
R5004 T7437 T7435 arg1Of Show,ChIP
R5005 T7437 T7436 arg1Of Show,Assays
R5006 T7439 T7434 arg2Of Sox6,and
R5007 T7439 T7437 arg1Of Sox6,Show
R5008 T7439 T7438 arg1Of Sox6,that
R5009 T7441 T7440 arg1Of Binds,Directly
R5010 T7441 T7442 arg1Of Binds,to
R5011 T7445 T7442 arg2Of Promoter,to
R5012 T7445 T7443 arg1Of Promoter,the
R5013 T7445 T7444 arg1Of Promoter,ɛy
R5014 T7446 T7447 arg1Of Sox6,might
R5015 T7446 T7448 arg1Of Sox6,repress
R5016 T7446 T7463 arg1Of Sox6,regulating
R5017 T7448 T7447 arg2Of repress,might
R5018 T7448 T7452 arg1Of repress,","
R5019 T7448 T7454 arg1Of repress,through
R5020 T7448 T7462 arg1Of repress,by
R5021 T7451 T7448 arg2Of promoter,repress
R5022 T7451 T7449 arg1Of promoter,the
R5023 T7451 T7450 arg1Of promoter,ɛy
R5024 T7454 T7461 arg1Of through,or
R5025 T7457 T7454 arg2Of contact,through
R5026 T7457 T7455 arg1Of contact,direct
R5027 T7457 T7456 arg1Of contact,physical
R5028 T7457 T7458 arg1Of contact,with
R5029 T7460 T7458 arg2Of promoter,with
R5030 T7460 T7459 arg1Of promoter,the
R5031 T7461 T7453 arg1Of or,either
R5032 T7462 T7461 arg2Of by,or
R5033 T7463 T7462 arg2Of regulating,by
R5034 T7464 T7463 arg2Of intermediates,regulating
R5035 T7464 T7465 arg1Of intermediates,affecting
R5036 T7468 T7465 arg2Of promoter,affecting
R5037 T7468 T7466 arg1Of promoter,the
R5038 T7468 T7467 arg1Of promoter,ɛy
R5039 T7470 T7469 arg1Of investigate,To
R5040 T7472 T7473 arg1Of Sox6,is
R5041 T7472 T7475 arg2Of Sox6,associated
R5042 T7475 T7470 arg2Of associated,investigate
R5043 T7475 T7471 arg1Of associated,whether
R5044 T7475 T7473 arg2Of associated,is
R5045 T7475 T7474 arg1Of associated,directly
R5046 T7475 T7476 arg1Of associated,with
R5047 T7479 T7476 arg2Of promoter,with
R5048 T7479 T7477 arg1Of promoter,the
R5049 T7479 T7478 arg1Of promoter,ɛy
R5050 T7481 T7470 arg1Of we,investigate
R5051 T7481 T7483 arg1Of we,performed
R5052 T7481 T7491 arg1Of we,using
R5053 T7483 T7469 modOf performed,To
R5054 T7483 T7480 arg1Of performed,","
R5055 T7483 T7482 arg1Of performed,first
R5056 T7483 T7491 modOf performed,using
R5057 T7487 T7483 arg2Of assays,performed
R5058 T7487 T7484 arg1Of assays,electrophoretic
R5059 T7487 T7485 arg1Of assays,mobility
R5060 T7487 T7486 arg1Of assays,shift
R5061 T7487 T7488 arg1Of assays,(
R5062 T7489 T7488 arg2Of EMSA,(
R5063 T7490 T7488 arg3Of ),(
R5064 T7494 T7491 arg2Of Sox6,using
R5065 T7494 T7492 arg1Of Sox6,a
R5066 T7494 T7493 arg1Of Sox6,c-Myc-tagged
R5067 T7494 T7495 arg1Of Sox6,in
R5068 T7501 T7500 arg1Of vitro,in
R5069 T7502 T7495 arg2Of system,in
R5070 T7502 T7496 arg1Of system,a
R5071 T7502 T7497 arg1Of system,reticulocyte
R5072 T7502 T7498 arg1Of system,lysate-based
R5073 T7502 T7499 arg1Of system,transcription/translation
R5074 T7502 T7501 arg1Of system,vitro
R5075 T7504 T7503 arg1Of probes,The
R5076 T7504 T7505 arg2Of probes,used
R5077 T7504 T7506 arg1Of probes,are
R5078 T7504 T7507 arg2Of probes,listed
R5079 T7507 T7506 arg2Of listed,are
R5080 T7507 T7508 arg1Of listed,in
R5081 T7510 T7508 arg2Of 3A,in
R5082 T7510 T7509 arg1Of 3A,Figure
R5083 T7513 T7512 arg1Of pair,36–base
R5084 T7513 T7514 arg1Of pair,(
R5085 T7515 T7514 arg2Of bp,(
R5086 T7516 T7514 arg3Of ),(
R5087 T7518 T7511 arg1Of probe,The
R5088 T7518 T7513 arg1Of probe,pair
R5089 T7518 T7517 arg1Of probe,WT
R5090 T7518 T7519 arg1Of probe,corresponds
R5091 T7519 T7520 arg1Of corresponds,to
R5092 T7523 T7520 arg2Of region,to
R5093 T7523 T7521 arg1Of region,the
R5094 T7523 T7522 arg1Of region,critical
R5095 T7523 T7524 arg1Of region,of
R5096 T7527 T7524 arg2Of promoter,of
R5097 T7527 T7525 arg1Of promoter,the
R5098 T7527 T7526 arg1Of promoter,ɛy
R5099 T7527 T7528 arg2Of promoter,defined
R5100 T7528 T7529 arg1Of defined,in
R5101 T7533 T7529 arg2Of analyses,in
R5102 T7533 T7530 arg1Of analyses,our
R5103 T7533 T7531 arg1Of analyses,promoter
R5104 T7533 T7532 arg1Of analyses,deletion
R5105 T7535 T7534 arg1Of probe,This
R5106 T7535 T7536 arg1Of probe,contains
R5107 T7541 T7536 arg2Of sites,contains
R5108 T7541 T7537 arg1Of sites,two
R5109 T7541 T7538 arg1Of sites,consensus
R5110 T7541 T7539 arg1Of sites,Sox/Sox6
R5111 T7541 T7540 arg1Of sites,binding
R5112 T7543 T7542 arg1Of included,Also
R5113 T7543 T7544 arg1Of included,in
R5114 T7543 T7547 arg2Of included,are
R5115 T7643 T7641 arg2Of probe,to
R5116 T7643 T7642 arg1Of probe,the
R5117 T7647 T7645 arg1Of Sox6,an
R5118 T7647 T7646 arg1Of Sox6,HA-tagged
R5119 T7647 T7648 arg1Of Sox6,was
R5120 T7647 T7649 arg2Of Sox6,used
R5121 T7649 T7630 modOf used,To
R5122 T7649 T7644 arg1Of used,","
R5123 T7649 T7648 arg2Of used,was
R5124 T7649 T7650 arg1Of used,in
R5125 T7652 T7650 arg2Of EMSA,in
R5126 T7652 T7651 arg1Of EMSA,another
R5127 T7652 T7653 arg1Of EMSA,that
R5128 T7652 T7654 arg1Of EMSA,confirmed
R5129 T7656 T7654 arg2Of results,confirmed
R5130 T7656 T7655 arg1Of results,these
R5131 T7656 T7657 arg1Of results,(
R5132 T7659 T7657 arg2Of 3C,(
R5133 T7659 T7658 arg1Of 3C,Figure
R5134 T7660 T7657 arg3Of ),(
R5135 T7664 T7663 arg1Of extracts,nuclear
R5136 T7546 T7544 arg2Of EMSA,in
R5137 T7546 T7545 arg1Of EMSA,our
R5138 T7664 T7665 arg1Of extracts,from
R5139 T7664 T7668 arg1Of extracts,were
R5140 T7664 T7669 arg2Of extracts,used
R5141 T7550 T7543 arg2Of probes,included
R5142 T7550 T7547 arg1Of probes,are
R5143 T7550 T7548 arg1Of probes,three
R5144 T7550 T7549 arg2Of probes,mutated
R5145 T7550 T7551 arg1Of probes,that
R5146 T7550 T7552 arg1Of probes,are
R5147 T7667 T7665 arg2Of cells,from
R5148 T7552 T7553 arg1Of are,","
R5149 T7552 T7554 arg1Of are,either
R5150 T7555 T7556 arg1Of truncated,(
R5151 T7555 T7560 arg1Of truncated,or
R5152 T7557 T7556 arg2Of M1,(
R5153 T7558 T7556 arg3Of ),(
R5154 T7560 T7552 arg2Of or,are
R5155 T7560 T7559 arg1Of or,","
R5156 T7560 T7567 arg1Of or,in
R5157 T7667 T7666 arg1Of cells,MEL
R5158 T7563 T7564 arg1Of M2,and
R5159 T7669 T7661 arg1Of used,Next
R5160 T7564 T7560 arg2Of and,or
R5161 T7564 T7561 arg1Of and,mutated
R5162 T7564 T7562 arg2Of and,(
R5163 T7565 T7564 arg2Of M3,and
R5164 T7566 T7562 arg3Of ),(
R5165 T7669 T7662 arg1Of used,","
R5166 T7669 T7668 arg2Of used,were
R5167 T7669 T7670 arg1Of used,in
R5168 T7570 T7567 arg2Of sites,in
R5169 T7570 T7568 arg1Of sites,Sox/Sox6
R5170 T7570 T7569 arg1Of sites,binding
R5171 T7570 T7571 arg1Of sites,(
R5172 T7671 T7670 arg2Of EMSA,in
R5173 T7573 T7571 arg2Of 3A,(
R5174 T7573 T7572 arg1Of 3A,Figure
R5175 T7574 T7571 arg3Of ),(
R5176 T7575 T7576 arg1Of Sox6,is
R5177 T7575 T7577 arg1Of Sox6,able
R5178 T7575 T7580 arg1Of Sox6,associate
R5179 T7671 T7672 arg1Of EMSA,employing
R5180 T7577 T7576 arg2Of able,is
R5181 T7676 T7672 arg2Of probe,employing
R5182 T7580 T7577 arg2Of associate,able
R5183 T7580 T7578 arg1Of associate,to
R5184 T7580 T7579 arg1Of associate,physically
R5185 T7580 T7581 arg1Of associate,with
R5186 T7584 T7581 arg2Of region,with
R5187 T7584 T7582 arg1Of region,the
R5188 T7584 T7583 arg1Of region,36-bp
R5189 T7584 T7585 arg1Of region,(
R5190 T7584 T7589 arg1Of region,within
R5191 T7676 T7673 arg1Of probe,the
R5192 T7587 T7585 arg2Of 3B,(
R5193 T7587 T7586 arg1Of 3B,Figure
R5194 T7676 T7674 arg1Of probe,same
R5195 T7588 T7585 arg3Of ),(
R5196 T7676 T7675 arg1Of probe,36-bp
R5197 T7678 T7677 arg1Of cells,MEL
R5198 T7592 T7589 arg2Of promoter,within
R5199 T7592 T7590 arg1Of promoter,the
R5200 T7592 T7591 arg1Of promoter,ɛy
R5201 T7592 T7593 arg2Of promoter,defined
R5202 T7598 T7593 arg1Of experiments,defined
R5203 T7598 T7594 arg2Of experiments,by
R5204 T7598 T7595 arg1Of experiments,the
R5205 T7598 T7596 arg1Of experiments,deletion
R5206 T7598 T7597 arg1Of experiments,analysis
R5207 T7598 T7599 arg1Of experiments,(
R5208 T7678 T7679 arg1Of cells,","
R5209 T7678 T7686 arg1Of cells,express
R5210 T7601 T7599 arg2Of 2C,(
R5211 T7601 T7600 arg1Of 2C,Figure
R5212 T7602 T7599 arg3Of ),(
R5213 T7678 T7693 arg1Of cells,ɛy
R5214 T7684 T7679 arg2Of line,","
R5215 T7605 T7603 arg1Of probe,The
R5216 T7605 T7604 arg1Of probe,36-bp
R5217 T7605 T7606 arg1Of probe,was
R5218 T7605 T7607 arg2Of probe,shifted
R5219 T7607 T7606 arg2Of shifted,was
R5220 T7684 T7680 arg1Of line,a
R5221 T7684 T7681 arg1Of line,murine
R5222 T7684 T7682 arg1Of line,erythroleukemic
R5223 T7684 T7683 arg1Of line,cell
R5224 T7686 T7691 arg1Of express,but
R5225 T7612 T7607 arg1Of protein,shifted
R5226 T7612 T7608 arg2Of protein,by
R5227 T7612 T7609 arg1Of protein,the
R5228 T7612 T7610 arg2Of protein,tagged
R5229 T7612 T7611 arg1Of protein,Sox6
R5230 T7616 T7617 arg1Of c-Myc,and
R5231 T7689 T7686 arg2Of globins,express
R5232 T7617 T7615 arg1Of and,both
R5233 T7618 T7617 arg2Of Sox6,and
R5234 T7619 T7616 arg1Of antibodies,c-Myc
R5235 T7619 T7618 arg1Of antibodies,Sox6
R5236 T7619 T7620 arg1Of antibodies,supershift
R5237 T7620 T7613 arg1Of supershift,Moreover
R5238 T7620 T7614 arg1Of supershift,","
R5239 T7620 T7623 arg1Of supershift,","
R5240 T7620 T7624 modOf supershift,indicating
R5241 T7622 T7620 arg2Of band,supershift
R5242 T7622 T7621 arg1Of band,the
R5243 T7689 T7687 arg1Of globins,adult
R5244 T7689 T7688 arg1Of globins,β
R5245 T7691 T7685 arg1Of but,","
R5246 T7627 T7626 arg1Of binding,the
R5247 T7627 T7628 arg1Of binding,is
R5248 T7627 T7629 arg1Of binding,Sox6-specific
R5249 T7628 T7624 arg2Of is,indicating
R5250 T7628 T7625 arg1Of is,that
R5251 T7629 T7628 arg2Of Sox6-specific,is
R5252 T7631 T7630 arg1Of rule,To
R5253 T7631 T7632 arg1Of rule,out
R5254 T7691 T7690 arg1Of but,","
R5255 T7634 T7631 arg2Of possibility,rule
R5256 T7634 T7633 arg1Of possibility,the
R5257 T7691 T7692 arg1Of but,not
R5258 T7693 T7691 arg2Of ɛy,but
R5259 T7638 T7636 arg1Of tag,the
R5260 T7638 T7637 arg1Of tag,c-Myc
R5261 T7639 T7638 arg1Of itself,tag
R5262 T7639 T7640 arg1Of itself,binds
R5263 T7640 T7634 arg2Of binds,possibility
R5264 T7640 T7635 arg1Of binds,that
R5265 T7640 T7641 arg1Of binds,to
R5266 T7693 T7694 arg1Of ɛy,[
R5267 T7695 T7694 arg2Of 33,[
R5268 T7696 T7694 arg3Of ],[
R5269 T7697 T7699 arg1Of Sox6,binds
R5270 T7699 T7698 arg1Of binds,directly
R5271 T7699 T7700 arg1Of binds,to
R5272 T7703 T7700 arg2Of sequence,to
R5273 T7742 T7738 arg2Of sites,of
R5274 T7742 T7739 arg1Of sites,putative
R5275 T7742 T7740 arg1Of sites,Sox/Sox6
R5276 T7742 T7741 arg1Of sites,binding
R5277 T7742 T7743 arg1Of sites,(
R5278 T7744 T7745 arg1Of M1,and
R5279 T7745 T7743 arg2Of and,(
R5280 T7746 T7745 arg2Of M3,and
R5281 T7703 T7701 arg1Of sequence,this
R5282 T7747 T7743 arg3Of ),(
R5283 T7703 T7702 arg1Of sequence,DNA
R5284 T7703 T7704 arg1Of sequence,in
R5285 T7706 T7704 arg2Of cells,in
R5286 T7750 T7748 arg2Of ability,abolish
R5287 T7750 T7749 arg1Of ability,their
R5288 T7750 T7751 modOf ability,to
R5289 T7752 T7751 arg1Of compete,to
R5290 T7752 T7753 arg1Of compete,in
R5291 T7706 T7705 arg1Of cells,MEL
R5292 T7706 T7707 arg1Of cells,(
R5293 T7709 T7707 arg2Of 3D,(
R5294 T7754 T7753 arg2Of EMSA,in
R5295 T7754 T7755 arg1Of EMSA,(
R5296 T7709 T7708 arg1Of 3D,Figure
R5297 T7757 T7755 arg2Of 3E,(
R5298 T7757 T7756 arg1Of 3E,Figure
R5299 T7758 T7755 arg3Of ),(
R5300 T7710 T7707 arg3Of ),(
R5301 T7762 T7759 arg1Of probe,The
R5302 T7762 T7760 arg1Of probe,M2
R5303 T7762 T7761 arg1Of probe,mutant
R5304 T7762 T7763 arg1Of probe,may
R5305 T7762 T7764 arg1Of probe,compete
R5306 T7764 T7763 arg2Of compete,may
R5307 T7764 T7765 arg1Of compete,partially
R5308 T7764 T7766 arg1Of compete,with
R5309 T7716 T7711 arg1Of sites,The
R5310 T7768 T7766 arg2Of binding,with
R5311 T7768 T7767 arg1Of binding,WT
R5312 T7770 T7769 arg1Of investigate,To
R5313 T7773 T7770 arg2Of significance,investigate
R5314 T7773 T7771 arg1Of significance,the
R5315 T7773 T7772 arg1Of significance,functional
R5316 T7773 T7774 arg1Of significance,of
R5317 T7716 T7712 arg1Of sites,intact
R5318 T7716 T7713 arg1Of sites,consensus
R5319 T7716 T7714 arg1Of sites,Sox/Sox6
R5320 T7716 T7715 arg1Of sites,binding
R5321 T7716 T7717 arg1Of sites,of
R5322 T7779 T7774 arg2Of sites,of
R5323 T7779 T7775 arg1Of sites,the
R5324 T7779 T7776 arg1Of sites,intact
R5325 T7779 T7777 arg1Of sites,Sox/Sox6
R5326 T7779 T7778 arg1Of sites,binding
R5327 T7716 T7721 arg1Of sites,are
R5328 T7716 T7722 arg2Of sites,required
R5329 T7720 T7717 arg2Of probe,of
R5330 T7785 T7781 arg1Of constructs,the
R5331 T7785 T7782 arg1Of constructs,ɛy
R5332 T7785 T7783 arg1Of constructs,promoter
R5333 T7785 T7784 arg1Of constructs,reporter
R5334 T7785 T7786 arg1Of constructs,with
R5335 T7785 T7791 arg1Of constructs,were
R5336 T7785 T7792 arg2Of constructs,co-transfected
R5337 T7790 T7786 arg2Of sites,with
R5338 T7790 T7787 arg2Of sites,mutagenized
R5339 T7790 T7788 arg1Of sites,Sox/Sox6
R5340 T7790 T7789 arg1Of sites,binding
R5341 T7720 T7718 arg1Of probe,the
R5342 T7792 T7769 modOf co-transfected,To
R5343 T7792 T7780 arg1Of co-transfected,","
R5344 T7792 T7791 arg2Of co-transfected,were
R5345 T7792 T7793 arg1Of co-transfected,with
R5346 T7720 T7719 arg1Of probe,DNA
R5347 T7722 T7721 arg2Of required,are
R5348 T7797 T7793 arg2Of vector,with
R5349 T7797 T7794 arg1Of vector,the
R5350 T7797 T7795 arg1Of vector,Sox6
R5351 T7797 T7796 arg1Of vector,overexpression
R5352 T7797 T7798 arg1Of vector,into
R5353 T7800 T7798 arg2Of cells,into
R5354 T7800 T7799 arg1Of cells,GM979
R5355 T7801 T7802 arg1Of Consistent,with
R5356 T7722 T7723 arg1Of required,for
R5357 T7722 T7726 arg1Of required,","
R5358 T7805 T7802 arg2Of results,with
R5359 T7805 T7803 arg1Of results,the
R5360 T7805 T7804 arg1Of results,EMSA
R5361 T7722 T7727 arg1Of required,as
R5362 T7725 T7723 arg2Of binding,for
R5363 T7725 T7724 arg1Of binding,the
R5364 T7812 T7807 arg1Of constructs,the
R5365 T7812 T7808 arg1Of constructs,mutant
R5366 T7812 T7809 arg1Of constructs,ɛy
R5367 T7812 T7810 arg1Of constructs,promoter
R5368 T7812 T7811 arg1Of constructs,reporter
R5369 T7812 T7813 arg1Of constructs,(
R5370 T7812 T7824 arg1Of constructs,do
R5371 T7812 T7826 arg1Of constructs,result
R5372 T7814 T7813 arg2Of with,(
R5373 T7728 T7727 arg2Of shown,as
R5374 T7728 T7729 arg1Of shown,in
R5375 T7732 T7729 arg2Of assay,in
R5376 T7821 T7814 arg2Of sites,with
R5377 T7821 T7815 arg1Of sites,either
R5378 T7821 T7816 arg1Of sites,one
R5379 T7821 T7817 arg1Of sites,or
R5380 T7821 T7818 arg1Of sites,both
R5381 T7821 T7819 arg1Of sites,Sox/Sox6
R5382 T7821 T7820 arg1Of sites,binding
R5383 T7821 T7822 arg2Of sites,mutagenized
R5384 T7823 T7813 arg3Of ),(
R5385 T7826 T7801 arg1Of result,Consistent
R5386 T7826 T7806 arg1Of result,","
R5387 T7826 T7824 arg2Of result,do
R5388 T7826 T7825 arg1Of result,not
R5389 T7826 T7827 arg1Of result,in
R5390 T7830 T7827 arg2Of repression,in
R5391 T7732 T7730 arg1Of assay,the
R5392 T7732 T7731 arg1Of assay,competition
R5393 T7732 T7733 arg1Of assay,(
R5394 T7735 T7733 arg2Of 3E,(
R5395 T7830 T7828 arg1Of repression,significant
R5396 T7830 T7829 arg1Of repression,promoter
R5397 T7830 T7831 arg1Of repression,in
R5398 T7833 T7831 arg2Of studies,in
R5399 T7833 T7832 arg1Of studies,transfection
R5400 T7833 T7834 arg1Of studies,(
R5401 T7836 T7834 arg2Of 3F,(
R5402 T7836 T7835 arg1Of 3F,Figure
R5403 T7735 T7734 arg1Of 3E,Figure
R5404 T7736 T7733 arg3Of ),(
R5405 T7737 T7738 arg1Of Ablation,of
R5406 T7737 T7748 arg1Of Ablation,abolish
R5407 T7935 T7933 arg1Of data,The
R5408 T7837 T7834 arg3Of ),(
R5409 T7935 T7934 arg1Of data,above
R5410 T7841 T7840 arg1Of sites,both
R5411 T7841 T7842 arg1Of sites,are
R5412 T7841 T7843 arg2Of sites,required
R5413 T7935 T7936 arg1Of data,(
R5414 T7935 T7943 arg1Of data,indicate
R5415 T7843 T7838 arg1Of required,Thus
R5416 T7843 T7839 arg1Of required,","
R5417 T7843 T7842 arg2Of required,are
R5418 T7843 T7844 arg1Of required,for
R5419 T7843 T7854 arg1Of required,to
R5420 T7844 T7852 arg1Of for,but
R5421 T7938 T7939 arg1Of 3,and
R5422 T7846 T7844 arg2Of repression,for
R5423 T7846 T7845 arg1Of repression,maximal
R5424 T7846 T7847 arg1Of repression,of
R5425 T7846 T7849 arg1Of repression,by
R5426 T7848 T7847 arg2Of ɛy,of
R5427 T7850 T7849 arg2Of Sox6,by
R5428 T7939 T7936 arg2Of and,(
R5429 T7852 T7851 arg1Of but,","
R5430 T7939 T7937 arg1Of and,Figures
R5431 T7854 T7852 arg2Of to,but
R5432 T7854 T7853 arg1Of to,not
R5433 T7940 T7939 arg2Of 4,and
R5434 T7857 T7854 arg2Of degree,to
R5435 T7857 T7855 arg1Of degree,the
R5436 T7857 T7856 arg1Of degree,same
R5437 T7941 T7936 arg3Of ),(
R5438 T7858 T7860 arg1Of We,tested
R5439 T7860 T7859 arg1Of tested,also
R5440 T7943 T7942 arg1Of indicate,clearly
R5441 T7862 T7863 arg1Of Sox6,binds
R5442 T7863 T7860 arg2Of binds,tested
R5443 T7863 T7861 arg1Of binds,whether
R5444 T7945 T7946 arg1Of Sox6,acts
R5445 T7946 T7943 arg2Of acts,indicate
R5446 T7863 T7864 arg1Of binds,to
R5447 T7863 T7869 arg1Of binds,vivo
R5448 T7946 T7944 arg1Of acts,that
R5449 T7946 T7947 arg1Of acts,as
R5450 T7867 T7864 arg2Of promoter,to
R5451 T7867 T7865 arg1Of promoter,the
R5452 T7867 T7866 arg1Of promoter,ɛy
R5453 T7869 T7868 arg1Of vivo,in
R5454 T7870 T7863 arg2Of using,binds
R5455 T7872 T7870 arg2Of immunoprecipitation,using
R5456 T7872 T7871 arg1Of immunoprecipitation,chromatin
R5457 T7872 T7873 arg1Of immunoprecipitation,(
R5458 T7872 T7876 arg1Of immunoprecipitation,(
R5459 T7874 T7873 arg2Of ChIP,(
R5460 T7946 T7954 arg1Of acts,by
R5461 T7875 T7873 arg3Of ),(
R5462 T7949 T7947 arg2Of repressor,as
R5463 T7877 T7876 arg2Of Figure,(
R5464 T7877 T7878 arg1Of Figure,4
R5465 T7879 T7876 arg3Of ),(
R5466 T7949 T7948 arg1Of repressor,a
R5467 T7882 T7880 arg1Of complex,The
R5468 T7882 T7881 arg1Of complex,Sox6-containing
R5469 T7882 T7883 arg1Of complex,was
R5470 T7882 T7884 arg2Of complex,immunoprecipitated
R5471 T7884 T7883 arg2Of immunoprecipitated,was
R5472 T7884 T7885 arg1Of immunoprecipitated,from
R5473 T7884 T7889 arg1Of immunoprecipitated,from
R5474 T7949 T7950 arg1Of repressor,of
R5475 T7885 T7888 arg1Of from,or
R5476 T7953 T7950 arg2Of gene,of
R5477 T7887 T7885 arg2Of cells,from
R5478 T7887 T7886 arg1Of cells,MEL
R5479 T7889 T7888 arg2Of from,or
R5480 T7891 T7889 arg2Of cells,from
R5481 T7891 T7890 arg1Of cells,liver
R5482 T7891 T7892 arg1Of cells,of
R5483 T7953 T7951 arg1Of gene,the
R5484 T7953 T7952 arg1Of gene,ɛy
R5485 T7956 T7954 arg2Of binding,by
R5486 T7896 T7892 arg2Of mice,of
R5487 T7896 T7893 arg1Of mice,15.5
R5488 T7896 T7894 arg1Of mice,dpc
R5489 T7896 T7895 arg1Of mice,WT
R5490 T7896 T7897 arg1Of mice,using
R5491 T7956 T7955 arg1Of binding,directly
R5492 T7956 T7957 arg1Of binding,to
R5493 T7899 T7897 arg2Of antibody,using
R5494 T7899 T7898 arg1Of antibody,Sox6
R5495 T7956 T7961 arg1Of binding,","
R5496 T7956 T7963 arg1Of binding,as
R5497 T7960 T7957 arg2Of promoter,to
R5498 T7902 T7900 arg1Of shows,Figure
R5499 T7902 T7901 arg1Of shows,4
R5500 T7902 T7903 arg1Of shows,that
R5501 T7902 T7914 arg1Of shows,in
R5502 T7960 T7958 arg1Of promoter,the
R5503 T7907 T7904 arg1Of promoter,the
R5504 T7907 T7905 arg1Of promoter,ɛy
R5505 T7907 T7906 arg1Of promoter,proximal
R5506 T7907 T7908 arg1Of promoter,is
R5507 T7907 T7910 arg2Of promoter,immunoprecipitated
R5508 T7960 T7959 arg1Of promoter,ɛy
R5509 T7963 T7962 arg1Of as,probably
R5510 T7910 T7903 arg2Of immunoprecipitated,that
R5511 T7910 T7908 arg2Of immunoprecipitated,is
R5512 T7910 T7909 arg1Of immunoprecipitated,readily
R5513 T7910 T7911 arg1Of immunoprecipitated,with
R5514 T7913 T7911 arg2Of antibody,with
R5515 T7913 T7912 arg1Of antibody,Sox6
R5516 T7965 T7963 arg2Of dimer,as
R5517 T7917 T7916 arg1Of cells,MEL
R5518 T7917 T7918 arg1Of cells,and
R5519 T7918 T7914 arg2Of and,in
R5520 T7918 T7915 arg1Of and,both
R5521 T7920 T7918 arg2Of cells,and
R5522 T7920 T7919 arg1Of cells,liver
R5523 T7965 T7964 arg1Of dimer,a
R5524 T7922 T7921 arg1Of IgG,Normal
R5525 T7922 T7923 arg1Of IgG,was
R5526 T7922 T7924 arg2Of IgG,used
R5528 T7924 T7923 arg2Of used,was
R5529 T7924 T7925 arg1Of used,as
R5530 T7928 T7925 arg2Of control,as
R5531 T7928 T7926 arg1Of control,a
R5532 T7928 T7927 arg1Of control,negative
R5533 T7928 T7929 arg1Of control,(
R5534 T7931 T7929 arg2Of 4A,(
R5535 T7931 T7930 arg1Of 4A,Figure
R5536 T7932 T7929 arg3Of ),(
R6272 T9131 T9129 arg1Of Expression,The
R6273 T9131 T9130 arg1Of Expression,Persistent
R6274 T9131 T9132 arg1Of Expression,of
R6275 T9131 T9135 arg1Of Expression,in
R6276 T9131 T9138 arg1Of Expression,Is
R6277 T9131 T9140 arg1Of Expression,to
R6278 T9134 T9132 arg2Of Globin,of
R6279 T9134 T9133 arg1Of Globin,ɛy
R6280 T9137 T9135 arg2Of Mice,in
R6281 T9137 T9136 arg1Of Mice,Sox6-Deficient
R6282 T9140 T9138 arg2Of to,Is
R6283 T9140 T9139 arg1Of to,Due
R6284 T9142 T9140 arg2Of Defect,to
R6285 T9142 T9141 arg1Of Defect,a
R6286 T9142 T9143 arg1Of Defect,in
R6287 T9146 T9143 arg2Of Mechanism,in
R6288 T9146 T9144 arg1Of Mechanism,the
R6289 T9146 T9145 arg1Of Mechanism,ɛy-Gene–Silencing
R6290 T9146 T9147 arg1Of Mechanism,in
R6291 T9150 T9147 arg2Of Cells,in
R6292 T9150 T9148 arg1Of Cells,Definitive
R6293 T9150 T9149 arg1Of Cells,Erythroid
R6294 T9156 T9153 arg1Of gene,the
R6295 T9156 T9154 arg1Of gene,ɛy
R6296 T9156 T9155 arg1Of gene,globin
R6297 T9156 T9157 arg1Of gene,is
R6298 T9156 T9159 arg2Of gene,expressed
R6299 T9156 T9164 arg1Of gene,silenced
R6300 T9159 T9160 arg1Of expressed,in
R6301 T9159 T9163 arg1Of expressed,and
R6302 T9162 T9160 arg2Of erythrocytes,in
R6303 T9162 T9161 arg1Of erythrocytes,primitive
R6304 T9163 T9151 arg1Of and,Normally
R6305 T9163 T9152 arg1Of and,","
R6306 T9163 T9157 arg2Of and,is
R6307 T9163 T9158 arg1Of and,exclusively
R6308 T9163 T9165 arg1Of and,in
R6309 T9164 T9163 arg2Of silenced,and
R6310 T9167 T9165 arg2Of erythrocytes,in
R6311 T9167 T9166 arg1Of erythrocytes,definitive
R6312 T9169 T9168 arg1Of determine,To
R6313 T9173 T9171 arg1Of expression,the
R6314 T9173 T9172 arg1Of expression,persistent
R6315 T9173 T9174 arg1Of expression,of
R6316 T9173 T9177 arg1Of expression,is
R6317 T9173 T9178 arg1Of expression,due
R6318 T9173 T9184 arg1Of expression,is
R6319 T9173 T9185 arg1Of expression,due
R6320 T9176 T9174 arg2Of globin,of
R6321 T9176 T9175 arg1Of globin,ɛy
R6322 T9177 T9183 arg1Of is,or
R6323 T9178 T9177 arg2Of due,is
R6324 T9178 T9179 arg1Of due,to
R6325 T9182 T9179 arg2Of erythrocytes,to
R6326 T9182 T9180 arg1Of erythrocytes,residual
R6327 T9182 T9181 arg1Of erythrocytes,primitive
R6328 T9183 T9169 arg2Of or,determine
R6329 T9183 T9170 arg1Of or,whether
R6330 T9184 T9183 arg2Of is,or
R6331 T9185 T9184 arg2Of due,is
R6332 T9185 T9186 arg1Of due,to
R6333 T9188 T9186 arg2Of expression,to
R6334 T9188 T9187 arg1Of expression,ectopic
R6335 T9188 T9189 arg1Of expression,of
R6336 T9188 T9192 arg1Of expression,in
R6337 T9191 T9189 arg2Of globin,of
R6338 T9191 T9190 arg1Of globin,ɛy
R6339 T9194 T9192 arg2Of erythrocytes,in
R6340 T9194 T9193 arg1Of erythrocytes,definitive
R6341 T9196 T9197 arg1Of we,examined
R6342 T9197 T9168 modOf examined,To
R6343 T9197 T9195 arg1Of examined,","
R6344 T9197 T9205 arg1Of examined,in
R6345 T9197 T9208 arg1Of examined,by
R6346 T9200 T9197 arg2Of pattern,examined
R6347 T9200 T9198 arg1Of pattern,the
R6348 T9200 T9199 arg1Of pattern,spatial
R6349 T9200 T9201 arg1Of pattern,of
R6350 T9204 T9201 arg2Of transcripts,of
R6351 T9204 T9202 arg1Of transcripts,ɛy
R6352 T9204 T9203 arg1Of transcripts,globin
R6353 T9207 T9205 arg2Of embryos,in
R6354 T9207 T9206 arg1Of embryos,mouse
R6355 T9210 T9209 arg1Of situ,in
R6356 T9211 T9208 arg2Of hybridization,by
R6357 T9211 T9210 arg1Of hybridization,situ
R6358 T9211 T9212 arg1Of hybridization,(
R6359 T9213 T9212 arg2Of Figure,(
R6360 T9213 T9214 arg1Of Figure,5
R6361 T9215 T9212 arg3Of ),(
R6362 T9217 T9216 arg2Of expected,As
R6363 T9220 T9219 arg1Of globin,ɛy
R6364 T9220 T9221 arg1Of globin,is
R6365 T9220 T9223 arg2Of globin,expressed
R6366 T9223 T9216 arg1Of expressed,As
R6367 T9223 T9218 arg1Of expressed,","
R6368 T9223 T9221 arg2Of expressed,is
R6369 T9223 T9222 arg1Of expressed,not
R6370 T9223 T9224 arg1Of expressed,in
R6371 T9228 T9224 arg2Of liver,in
R6372 T9228 T9225 arg1Of liver,the
R6373 T9228 T9226 arg1Of liver,WT
R6374 T9228 T9227 arg1Of liver,14.5-dpc
R6375 T9228 T9229 arg1Of liver,","
R6376 T9231 T9229 arg2Of site,","
R6377 T9231 T9230 arg1Of site,the
R6378 T9231 T9232 arg1Of site,of
R6379 T9231 T9235 arg1Of site,in
R6380 T9234 T9232 arg2Of erythropoiesis,of
R6381 T9234 T9233 arg1Of erythropoiesis,definitive
R6382 T9237 T9235 arg2Of fetus,in
R6383 T9237 T9236 arg1Of fetus,the
R6384 T9239 T9238 arg2Of contrast,In
R6385 T9245 T9241 arg1Of expression,abundant
R6386 T9245 T9242 arg1Of expression,ectopic
R6387 T9245 T9243 arg1Of expression,ɛy
R6388 T9245 T9244 arg1Of expression,mRNA
R6389 T9245 T9246 arg1Of expression,is
R6390 T9245 T9247 arg2Of expression,seen
R6391 T9247 T9238 arg1Of seen,In
R6392 T9247 T9240 arg1Of seen,","
R6393 T9247 T9246 arg2Of seen,is
R6394 T9247 T9248 arg1Of seen,in
R6395 T9250 T9248 arg2Of liver,in
R6396 T9250 T9249 arg1Of liver,the
R6397 T9250 T9251 arg1Of liver,of
R6398 T9253 T9251 arg2Of mutants,of
R6399 T9253 T9252 arg1Of mutants,14.5-dpc
R6400 T9253 T9254 arg1Of mutants,(
R6401 T9257 T9254 arg2Of A–D,(
R6402 T9257 T9255 arg1Of A–D,Figure
R6403 T9257 T9256 arg1Of A–D,5
R6404 T9258 T9254 arg3Of ),(
R6405 T9262 T9261 arg1Of expression,the
R6406 T9262 T9263 arg1Of expression,of
R6407 T9262 T9266 arg1Of expression,is
R6408 T9262 T9268 arg1Of expression,abundant
R6409 T9265 T9263 arg2Of globin,of
R6410 T9265 T9264 arg1Of globin,βmaj/min
R6411 T9266 T9259 arg1Of is,However
R6412 T9266 T9260 arg1Of is,","
R6413 T9268 T9266 arg2Of abundant,is
R6414 T9268 T9267 arg1Of abundant,equally
R6415 T9268 T9269 arg1Of abundant,in
R6416 T9271 T9272 arg1Of WT,and
R6417 T9273 T9272 arg2Of p100H,and
R6418 T9275 T9269 arg2Of mice,in
R6419 T9275 T9270 arg1Of mice,both
R6420 T9275 T9271 arg1Of mice,WT
R6421 T9275 T9273 arg1Of mice,p100H
R6422 T9275 T9274 arg1Of mice,mutant
R6423 T9275 T9276 arg1Of mice,(
R6424 T9279 T9280 arg1Of E,and
R6425 T9280 T9276 arg2Of and,(
R6426 T9280 T9277 arg1Of and,Figure
R6427 T9280 T9278 arg1Of and,5
R6428 T9281 T9280 arg2Of F,and
R6429 T9282 T9276 arg3Of ),(
R6430 T9284 T9283 arg1Of data,These
R6431 T9284 T9285 arg1Of data,demonstrate
R6432 T9285 T9309 arg1Of demonstrate,","
R6433 T9285 T9310 modOf demonstrate,suggesting
R6434 T9290 T9287 arg1Of levels,the
R6435 T9290 T9288 arg1Of levels,persistent
R6436 T9290 T9289 arg1Of levels,high
R6437 T9290 T9291 arg1Of levels,of
R6438 T9290 T9293 arg1Of levels,are
R6439 T9290 T9294 arg1Of levels,due
R6440 T9292 T9291 arg2Of ɛy,of
R6441 T9293 T9285 arg2Of are,demonstrate
R6442 T9293 T9286 arg1Of are,that
R6443 T9294 T9293 arg2Of due,are
R6444 T9294 T9295 arg1Of due,to
R6445 T9297 T9295 arg2Of expression,to
R6446 T9297 T9296 arg1Of expression,ectopic
R6447 T9297 T9298 arg1Of expression,in
R6448 T9302 T9298 arg2Of cells,in
R6449 T9302 T9299 arg1Of cells,the
R6450 T9302 T9300 arg1Of cells,definitive
R6451 T9302 T9301 arg1Of cells,erythroid
R6452 T9302 T9303 arg1Of cells,that
R6453 T9302 T9304 arg1Of cells,mature
R6454 T9304 T9305 arg1Of mature,in
R6455 T9308 T9305 arg2Of liver,in
R6456 T9308 T9306 arg1Of liver,the
R6457 T9308 T9307 arg1Of liver,fetal
R6458 T9312 T9313 arg1Of there,is
R6459 T9313 T9310 arg2Of is,suggesting
R6460 T9313 T9311 arg1Of is,that
R6461 T9316 T9313 arg2Of defect,is
R6462 T9316 T9314 arg1Of defect,an
R6463 T9316 T9315 arg1Of defect,intrinsic
R6464 T9316 T9317 arg1Of defect,of
R6465 T9316 T9322 arg1Of defect,in
R6466 T9321 T9317 arg2Of mechanism,of
R6467 T9321 T9318 arg1Of mechanism,the
R6468 T9321 T9319 arg1Of mechanism,ɛy
R6469 T9321 T9320 arg1Of mechanism,silencing
R6470 T9324 T9322 arg2Of mice,in
R6471 T9324 T9323 arg1Of mice,Sox6-null
R6781 T9864 T9862 arg1Of Pattern,The
R6782 T9864 T9863 arg1Of Pattern,Expression
R6783 T9864 T9865 arg1Of Pattern,of
R6784 T9864 T9867 arg1Of Pattern,Suggests
R6785 T9866 T9865 arg2Of Sox6,of
R6786 T9867 T9870 arg1Of Suggests,in
R6787 T9869 T9867 arg2Of Role,Suggests
R6788 T9869 T9868 arg1Of Role,a
R6789 T9872 T9870 arg2Of Erythropoiesis,in
R6790 T9872 T9871 arg1Of Erythropoiesis,Definitive
R6791 T9874 T9873 arg1Of observation,The
R6792 T9874 T9891 arg1Of observation,suggests
R6793 T9877 T9876 arg1Of mice,Sox6-deficient
R6794 T9877 T9879 arg1Of mice,express
R6795 T9879 T9874 arg2Of express,observation
R6796 T9879 T9875 arg1Of express,that
R6797 T9879 T9878 arg1Of express,ectopically
R6798 T9879 T9882 arg1Of express,in
R6799 T9881 T9879 arg2Of globin,express
R6800 T9881 T9880 arg1Of globin,ɛy
R6801 T9883 T9882 arg2Of liver,in
R6802 T9883 T9884 arg1Of liver,","
R6803 T9883 T9885 arg1Of liver,where
R6804 T9888 T9886 arg1Of cells,definitive
R6805 T9888 T9887 arg1Of cells,erythroid
R6806 T9888 T9889 arg1Of cells,mature
R6807 T9889 T9885 arg2Of mature,where
R6808 T9891 T9890 arg1Of suggests,","
R6809 T9893 T9894 arg1Of Sox6,is
R6810 T9894 T9891 arg2Of is,suggests
R6811 T9894 T9892 arg1Of is,that
R6812 T9897 T9894 arg2Of regulator,is
R6813 T9897 T9895 arg1Of regulator,an
R6814 T9897 T9896 arg1Of regulator,important
R6815 T9897 T9898 arg1Of regulator,in
R6816 T9900 T9898 arg2Of erythropoiesis,in
R6817 T9900 T9899 arg1Of erythropoiesis,definitive
R6818 T9902 T9901 arg1Of determine,To
R6819 T9904 T9905 arg1Of temporal,and
R6820 T9906 T9905 arg2Of spatial,and
R6821 T9908 T9902 arg2Of pattern,determine
R6822 T9908 T9903 arg1Of pattern,the
R6823 T9908 T9904 arg1Of pattern,temporal
R6824 T9908 T9906 arg1Of pattern,spatial
R6825 T9908 T9907 arg1Of pattern,expression
R6826 T9908 T9909 arg1Of pattern,of
R6827 T9910 T9909 arg2Of Sox6,of
R6828 T9913 T9912 arg1Of blot,Northern
R6829 T9913 T9914 arg1Of blot,and
R6830 T9914 T9919 arg1Of and,were
R6831 T9914 T9920 arg2Of and,employed
R6832 T9916 T9915 arg1Of situ,in
R6833 T9918 T9914 arg2Of assays,and
R6834 T9918 T9916 arg1Of assays,situ
R6835 T9918 T9917 arg1Of assays,hybridization
R6836 T9920 T9901 modOf employed,To
R6837 T9920 T9911 arg1Of employed,","
R6838 T9920 T9919 arg2Of employed,were
R6839 T9922 T9921 arg2Of shown,As
R6840 T9922 T9923 arg1Of shown,in
R6841 T9925 T9923 arg2Of 6A,in
R6842 T9925 T9924 arg1Of 6A,Figure
R6843 T9927 T9928 arg1Of Sox6,is
R6844 T9927 T9929 arg1Of Sox6,detectable
R6845 T9928 T9921 arg1Of is,As
R6846 T9928 T9926 arg1Of is,","
R6847 T9928 T9937 arg1Of is,","
R6848 T9928 T9938 arg1Of is,coincident
R6849 T9929 T9928 arg2Of detectable,is
R6850 T9929 T9930 arg1Of detectable,by
R6851 T9932 T9930 arg2Of blot,by
R6852 T9932 T9931 arg1Of blot,Northern
R6853 T9932 T9933 arg1Of blot,beginning
R6854 T9933 T9934 arg1Of beginning,at
R6855 T9936 T9934 arg2Of dpc,at
R6856 T9936 T9935 arg1Of dpc,10.5
R6857 T9938 T9939 arg1Of coincident,with
R6858 T9942 T9939 arg2Of onset,with
R6859 T9942 T9940 arg1Of onset,the
R6860 T9942 T9941 arg1Of onset,temporal
R6861 T9942 T9943 arg1Of onset,of
R6862 T9942 T9946 arg1Of onset,in
R6863 T9945 T9943 arg2Of erythropoiesis,of
R6864 T9945 T9944 arg1Of erythropoiesis,definitive
R6865 T9948 T9946 arg2Of liver,in
R6866 T9948 T9947 arg1Of liver,the
R6867 T9952 T9951 arg1Of situ,in
R6868 T9953 T9952 arg1Of hybridization,situ
R6869 T9953 T9954 arg1Of hybridization,shows
R6870 T9954 T9949 arg1Of shows,Furthermore
R6871 T9954 T9950 arg1Of shows,","
R6872 T9956 T9957 arg1Of Sox6,is
R6873 T9956 T9959 arg2Of Sox6,transcribed
R6874 T9959 T9954 arg2Of transcribed,shows
R6875 T9959 T9955 arg1Of transcribed,that
R6876 T9959 T9957 arg2Of transcribed,is
R6877 T9959 T9958 arg1Of transcribed,highly
R6878 T9959 T9960 arg1Of transcribed,in
R6879 T9959 T9966 arg1Of transcribed,in
R6880 T9960 T9964 arg1Of in,but
R6881 T9962 T9960 arg2Of liver,in
R6882 T9962 T9961 arg1Of liver,12.5-dpc
R6883 T9964 T9963 arg1Of but,","
R6884 T9966 T9964 arg2Of in,but
R6885 T9966 T9965 arg1Of in,not
R6886 T9970 T9966 arg2Of islands,in
R6887 T9970 T9967 arg1Of islands,yolk
R6888 T9970 T9968 arg1Of islands,sac
R6889 T9970 T9969 arg1Of islands,blood
R6890 T9970 T9971 arg1Of islands,at
R6891 T9973 T9971 arg2Of dpc,at
R6892 T9973 T9972 arg1Of dpc,7.5
R6893 T9973 T9974 arg1Of dpc,(
R6894 T9976 T9974 arg2Of 6B,(
R6895 T9976 T9975 arg1Of 6B,Figure
R6896 T9977 T9974 arg3Of ),(
R6897 T9981 T9980 arg1Of expression,Sox6
R6898 T9981 T9982 arg1Of expression,is
R6899 T9981 T9986 arg1Of expression,coincident
R6900 T9982 T9978 arg1Of is,Therefore
R6901 T9982 T9979 arg1Of is,","
R6902 T9983 T9984 arg1Of temporally,and
R6903 T9985 T9984 arg2Of spatially,and
R6904 T9986 T9982 arg2Of coincident,is
R6905 T9986 T9983 arg1Of coincident,temporally
R6906 T9986 T9985 arg1Of coincident,spatially
R6907 T9986 T9987 arg1Of coincident,with
R6908 T9988 T9990 arg1Of definitive,but
R6909 T9990 T9989 arg1Of but,","
R6910 T9992 T9990 arg2Of primitive,but
R6911 T9992 T9991 arg1Of primitive,not
R6912 T9994 T9987 arg2Of erythropoiesis,with
R6913 T9994 T9988 arg1Of erythropoiesis,definitive
R6914 T9994 T9992 arg1Of erythropoiesis,primitive
R6915 T9994 T9993 arg1Of erythropoiesis,","
R6916 T9996 T9995 arg1Of data,These
R6917 T9996 T9998 arg2Of data,taken
R6918 T9996 T10023 arg1Of data,demonstrate
R6919 T9998 T9997 arg1Of taken,","
R6920 T9998 T9999 arg1Of taken,together
R6921 T9998 T10000 arg1Of taken,with
R6922 T10002 T10000 arg2Of observation,with
R6923 T10002 T10001 arg1Of observation,the
R6924 T10005 T10004 arg1Of globin,ɛy
R6925 T10005 T10006 arg1Of globin,is
R6926 T10005 T10008 arg2Of globin,expressed
R6927 T10008 T10002 arg2Of expressed,observation
R6928 T10008 T10003 arg1Of expressed,that
R6929 T10008 T10006 arg2Of expressed,is
R6930 T10008 T10007 arg1Of expressed,highly
R6931 T10008 T10009 arg1Of expressed,in
R6932 T10012 T10009 arg2Of cells,in
R6933 T10012 T10010 arg1Of cells,the
R6934 T10012 T10011 arg1Of cells,liver
R6935 T10012 T10013 arg1Of cells,of
R6936 T10017 T10013 arg2Of mice,of
R6937 T10017 T10014 arg1Of mice,14.5-dpc
R6938 T10017 T10015 arg1Of mice,p100H
R6939 T10017 T10016 arg1Of mice,mutant
R6940 T10017 T10018 arg1Of mice,(
R6941 T10019 T10018 arg2Of Figure,(
R6942 T10019 T10020 arg1Of Figure,5
R6943 T10021 T10018 arg3Of ),(
R6944 T10023 T10022 arg1Of demonstrate,","
R6945 T10023 T10027 arg1Of demonstrate,in
R6946 T10026 T10023 arg2Of functions,demonstrate
R6947 T10026 T10024 arg1Of functions,that
R6948 T10026 T10025 arg1Of functions,Sox6
R6949 T10029 T10027 arg2Of erythropoiesis,in
R6950 T10029 T10028 arg1Of erythropoiesis,definitive
R7164 T10376 T10371 arg1Of Numbers,Mutant
R7165 T10376 T10372 arg1Of Numbers,p100H
R7166 T10376 T10373 arg1Of Numbers,Mice
R7167 T10376 T10374 arg1Of Numbers,Have
R7168 T10376 T10375 arg1Of Numbers,Higher
R7169 T10376 T10377 arg1Of Numbers,of
R7170 T10380 T10377 arg2Of Cells,of
R7171 T10380 T10378 arg1Of Cells,Nucleated
R7172 T10380 T10379 arg1Of Cells,Red
R7173 T10385 T10381 arg2Of effects,Among
R7174 T10385 T10382 arg1Of effects,the
R7175 T10385 T10383 arg1Of effects,other
R7176 T10385 T10384 arg1Of effects,Sox6
R7177 T10385 T10386 arg1Of effects,in
R7178 T10387 T10386 arg2Of erythropoiesis,in
R7179 T10389 T10390 arg1Of we,have
R7180 T10389 T10391 arg1Of we,noticed
R7181 T10391 T10381 arg1Of noticed,Among
R7182 T10391 T10388 arg1Of noticed,","
R7183 T10391 T10390 arg2Of noticed,have
R7184 T10393 T10394 arg1Of there,are
R7185 T10394 T10391 arg2Of are,noticed
R7186 T10394 T10392 arg1Of are,that
R7187 T10394 T10405 arg1Of are,than
R7188 T10394 T10409 arg1Of are,at
R7189 T10396 T10395 arg1Of nucleated,more
R7190 T10399 T10394 arg2Of cells,are
R7191 T10399 T10396 arg1Of cells,nucleated
R7192 T10399 T10397 arg1Of cells,red
R7193 T10399 T10398 arg1Of cells,blood
R7194 T10399 T10400 arg1Of cells,circulating
R7195 T10400 T10401 arg1Of circulating,in
R7196 T10404 T10401 arg2Of mice,in
R7197 T10404 T10402 arg1Of mice,p100H
R7198 T10404 T10403 arg1Of mice,mutant
R7199 T10406 T10405 arg2Of in,than
R7200 T10408 T10406 arg2Of mice,in
R7201 T10408 T10407 arg1Of mice,WT
R7202 T10411 T10410 arg1Of dpc,14.5
R7203 T10411 T10412 arg1Of dpc,and
R7204 T10412 T10409 arg2Of and,at
R7205 T10414 T10412 arg2Of dpc,and
R7206 T10414 T10413 arg1Of dpc,18.5
R7207 T10414 T10415 arg1Of dpc,(
R7208 T10417 T10415 arg2Of 7A,(
R7209 T10417 T10416 arg1Of 7A,Figure
R7210 T10418 T10415 arg3Of ),(
R7211 T10423 T10421 arg2Of day,at
R7212 T10423 T10422 arg1Of day,postnatal
R7213 T10423 T10424 arg1Of day,10.5
R7214 T10426 T10427 arg1Of we,do
R7215 T10426 T10429 arg1Of we,see
R7216 T10429 T10419 arg1Of see,However
R7217 T10429 T10420 arg1Of see,","
R7218 T10429 T10421 arg1Of see,at
R7219 T10429 T10425 arg1Of see,","
R7220 T10429 T10427 arg2Of see,do
R7221 T10429 T10428 arg1Of see,not
R7222 T10429 T10440 arg1Of see,","
R7223 T10429 T10441 modOf see,suggesting
R7224 T10430 T10429 arg2Of circulating,see
R7225 T10432 T10431 arg1Of red,nucleated
R7226 T10433 T10430 arg2Of cells,circulating
R7227 T10433 T10432 arg1Of cells,red
R7228 T10433 T10434 arg1Of cells,in
R7229 T10436 T10437 arg1Of WT,or
R7230 T10437 T10434 arg2Of or,in
R7231 T10437 T10435 arg1Of or,either
R7232 T10439 T10437 arg2Of mice,or
R7233 T10439 T10438 arg1Of mice,mutant
R7234 T10443 T10444 arg1Of this,may
R7235 T10443 T10445 arg1Of this,be
R7236 T10445 T10441 arg2Of be,suggesting
R7237 T10445 T10442 arg1Of be,that
R7238 T10445 T10444 arg2Of be,may
R7239 T10448 T10445 arg2Of effect,be
R7240 T10448 T10446 arg1Of effect,a
R7241 T10448 T10447 arg1Of effect,transient
R7242 T10450 T10449 arg2Of addition,In
R7243 T10454 T10452 arg1Of liver,the
R7244 T10454 T10453 arg1Of liver,mutant
R7245 T10454 T10455 arg1Of liver,shows
R7246 T10455 T10449 arg1Of shows,In
R7247 T10455 T10451 arg1Of shows,","
R7248 T10458 T10455 arg2Of increase,shows
R7249 T10458 T10456 arg1Of increase,a
R7250 T10458 T10457 arg1Of increase,significant
R7251 T10458 T10459 arg1Of increase,in
R7252 T10462 T10459 arg2Of cells,in
R7253 T10462 T10460 arg1Of cells,hematopoietic
R7254 T10462 T10461 arg1Of cells,precursor
R7255 T10462 T10463 arg1Of cells,including
R7256 T10465 T10463 arg2Of erythrocytes,including
R7257 T10465 T10464 arg1Of erythrocytes,nucleated
R7258 T10465 T10466 arg1Of erythrocytes,at
R7259 T10468 T10466 arg2Of dpc,at
R7260 T10468 T10467 arg1Of dpc,18.5
R7261 T10468 T10469 arg1Of dpc,(
R7262 T10471 T10469 arg2Of 7B,(
R7263 T10471 T10470 arg1Of 7B,Figure
R7264 T10472 T10469 arg3Of ),(
R7265 T10474 T10473 arg1Of alteration,This
R7266 T10474 T10475 arg1Of alteration,is
R7267 T10474 T10476 arg2Of alteration,noted
R7268 T10476 T10475 arg2Of noted,is
R7269 T10476 T10478 arg1Of noted,early
R7270 T10478 T10477 arg1Of early,as
R7271 T10478 T10479 arg1Of early,as
R7272 T10481 T10479 arg2Of dpc,as
R7273 T10481 T10480 arg1Of dpc,14.5
R7274 T10483 T10482 arg1Of observations,These
R7275 T10483 T10484 arg1Of observations,suggest
R7276 T10487 T10486 arg2Of silencing,besides
R7277 T10491 T10487 arg2Of gene,silencing
R7278 T10491 T10488 arg1Of gene,the
R7279 T10491 T10489 arg1Of gene,ɛy
R7280 T10491 T10490 arg1Of gene,globin
R7281 T10493 T10487 arg1Of Sox6,silencing
R7282 T10493 T10494 arg1Of Sox6,may
R7283 T10493 T10495 arg1Of Sox6,affect
R7284 T10495 T10484 arg2Of affect,suggest
R7285 T10495 T10485 arg1Of affect,that
R7286 T10495 T10486 arg1Of affect,besides
R7287 T10495 T10492 arg1Of affect,","
R7288 T10495 T10494 arg2Of affect,may
R7289 T10498 T10495 arg2Of maturation,affect
R7290 T10498 T10496 arg1Of maturation,red
R7291 T10498 T10497 arg1Of maturation,cell

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T7238 10575-10597 Antecedent denotes Sox/Sox6 binding sites
T7237 10703-10713 Anaphor denotes both sites
T7236 9262-9274 Antecedent denotes 36-bp region
T7235 9891-9908 Anaphor denotes this DNA sequence
R4979 T7235 T7236 boundBy this DNA sequence,36-bp region
R4980 T7237 T7238 boundBy both sites,Sox/Sox6 binding sites

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T7272 11275-11279 Protein denotes Sox6
T7271 11116-11120 Protein denotes Sox6
T7270 11060-11062 Protein denotes ɛy
T7269 11021-11025 Protein denotes Sox6
T7268 10913-10917 Protein denotes Sox6
T7267 10834-10836 Protein denotes ɛy
T7266 10816-10820 Protein denotes Sox6
T7265 10759-10763 Protein denotes Sox6
T7264 10753-10755 Protein denotes ɛy
T7263 10518-10520 Protein denotes ɛy
T7262 10428-10432 Protein denotes Sox6
T7261 10327-10329 Protein denotes ɛy
T7260 9868-9872 Protein denotes Sox6
T7259 9859-9861 Protein denotes ɛy
T7258 9840-9849 Protein denotes β globins
T7257 9619-9623 Protein denotes Sox6
T7256 9609-9611 Protein denotes HA
T7255 9569-9574 Protein denotes c-Myc
T7254 9517-9521 Protein denotes Sox6
T7253 9449-9453 Protein denotes Sox6
T7252 9439-9444 Protein denotes c-Myc
T7251 9410-9414 Protein denotes Sox6
T7250 9298-9300 Protein denotes ɛy
T7249 9216-9220 Protein denotes Sox6
T5681 5140-5142 Protein denotes ɛy
T5680 5117-5121 Protein denotes Sox6
T5679 5095-5100 Protein denotes CtBP2
T5678 4997-5002 Protein denotes CtBP2
T5677 4977-4982 Protein denotes fgf-3
T5676 4963-4968 Protein denotes CtBP2
T5675 4867-4871 Protein denotes Sox6
T5674 3444-3446 Protein denotes ɛy
T5673 3419-3423 Protein denotes Sox6
T5672 3268-3272 Protein denotes Sox6
T5671 3100-3104 Protein denotes Sox6
T5670 2997-3007 Protein denotes luciferase
T5669 2950-2952 Protein denotes ɛy
T5668 2853-2855 Protein denotes ɛy
T5667 2818-2830 Protein denotes beta globins
T5666 2805-2807 Protein denotes ɛy
T5665 2637-2639 Protein denotes ɛy
T5664 2611-2615 Protein denotes Sox6
T5663 2575-2577 Protein denotes ɛy
T5662 2530-2532 Protein denotes ɛy
T5661 2421-2423 Protein denotes ɛy
T5660 2393-2397 Protein denotes Sox6
T9085 13332-13336 Protein denotes Sox6
T9084 13306-13308 Protein denotes ɛy
T9083 13155-13157 Protein denotes ɛy
T9082 13013-13023 Protein denotes min globin
T9081 13008-13012 Protein denotes βmaj
T9080 12905-12907 Protein denotes ɛy
T9079 12770-12779 Protein denotes ɛy globin
T9078 12681-12690 Protein denotes ɛy globin
T9077 12608-12617 Protein denotes ɛy globin
T9076 12521-12530 Protein denotes ɛy globin
T9075 12364-12373 Protein denotes ɛy globin
T9074 12292-12294 Protein denotes ɛy
T9073 12246-12250 Protein denotes Sox6
T9072 12233-12242 Protein denotes ɛy Globin
T10362 16740-16744 Protein denotes Sox6
T10361 16724-16733 Protein denotes ɛy globin
T10360 16137-16141 Protein denotes Sox6
T4486 1853-1856 Protein denotes min
T4485 1848-1852 Protein denotes βmaj
T4484 1728-1730 Protein denotes ɛy
T4483 1075-1083 Protein denotes β globin
T4482 1001-1010 Protein denotes ɛy globin
T4481 889-892 Protein denotes βh1
T4480 883-884 Protein denotes ζ
T4479 595-597 Protein denotes ɛy
T4478 322-326 Protein denotes Sox6
T4477 220-224 Protein denotes Sox6
T4476 87-96 Protein denotes ɛy globin
T4475 63-67 Protein denotes Sox6
T4474 56-58 Protein denotes ɛy
T4473 48-54 Protein denotes Globin
T7248 8957-8959 Protein denotes ɛy
T7247 8764-8768 Protein denotes Sox6
T7246 8751-8756 Protein denotes c-Myc
T7245 8666-8668 Protein denotes ɛy
T7244 8629-8633 Protein denotes Sox6
T7243 8593-8595 Protein denotes ɛy
T7242 8478-8480 Protein denotes ɛy
T7241 8455-8459 Protein denotes Sox6
T7240 8443-8445 Protein denotes ɛy
T7239 8416-8420 Protein denotes Sox6
T9829 14967-14971 Protein denotes Sox6
T9828 14859-14868 Protein denotes ɛy globin
T9827 14699-14703 Protein denotes Sox6
T9826 14584-14588 Protein denotes Sox6
T9825 14401-14405 Protein denotes Sox6
T9824 14310-14314 Protein denotes Sox6
T9823 14189-14193 Protein denotes Sox6
T9822 14114-14123 Protein denotes ɛy globin
T9821 14074-14078 Protein denotes Sox6
T9820 14003-14007 Protein denotes Sox6
T5692 5708-5712 Protein denotes Sox6
T5691 5666-5668 Protein denotes ɛy
T5690 5589-5591 Protein denotes ɛy
T5689 5538-5543 Protein denotes CtBP2
T5688 5521-5523 Protein denotes ɛy
T5687 5502-5506 Protein denotes Sox6
T5686 5435-5437 Protein denotes ɛy
T5685 5395-5399 Protein denotes Sox6
T5684 5279-5284 Protein denotes CtBP2
T5683 5274-5278 Protein denotes Sox6
T5682 5199-5203 Protein denotes Sox6
T7274 11342-11344 Protein denotes ɛy
T7273 11307-11309 Protein denotes ɛy

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T10037 14967-14971 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10036 14699-14703 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10035 14584-14588 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10034 14401-14405 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10033 14310-14314 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10032 14189-14193 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10031 14074-14078 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10030 14003-14007 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10500 16740-16744 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T10499 16137-16141 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T9326 13332-13336 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7974 9449-9453 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7973 9410-9414 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7972 9216-9220 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7971 9184-9188 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7970 9050-9054 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7969 8764-8768 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7968 8629-8633 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7967 8455-8459 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7966 8416-8420 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7989 11275-11279 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7988 11116-11120 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7987 11021-11025 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7986 10913-10917 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7985 10816-10820 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7984 10759-10763 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7983 10579-10583 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7982 10428-10432 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7981 10380-10384 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7980 10303-10307 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7979 10098-10102 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7978 9960-9964 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7977 9868-9872 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7976 9619-9623 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T7975 9517-9521 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6220 5538-5543 http://www.uniprot.org/uniprot/P56545 denotes CtBP2
T6219 5279-5284 http://www.uniprot.org/uniprot/P56545 denotes CtBP2
T6218 5095-5100 http://www.uniprot.org/uniprot/P56545 denotes CtBP2
T6217 4997-5002 http://www.uniprot.org/uniprot/P56545 denotes CtBP2
T6216 4963-4968 http://www.uniprot.org/uniprot/P56545 denotes CtBP2
T9325 12246-12250 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6212 5502-5506 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6211 5395-5399 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6210 5274-5278 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6209 5199-5203 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6208 5117-5121 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6207 4867-4871 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6206 3419-3423 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6205 3268-3272 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6204 3100-3104 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6203 2611-2615 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6202 2393-2397 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T4878 322-326 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T4877 220-224 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T4876 63-67 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6215 2997-3007 http://www.uniprot.org/uniprot/P08659 denotes luciferase
T6214 5771-5775 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T6213 5708-5712 http://www.uniprot.org/uniprot/P35712 denotes Sox6

UBERON-AE

Id Subject Object Predicate Lexical cue
T10346 16497-16502 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T10345 16219-16224 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T9781 14650-14663 http://purl.obolibrary.org/obo/UBERON_0003061 denotes blood islands
T9780 14650-14655 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T9779 14646-14649 http://purl.obolibrary.org/obo/UBERON_0009856 denotes sac
T9778 14641-14663 http://purl.obolibrary.org/obo/UBERON_0011919 denotes yolk sac blood islands
T9777 14641-14649 http://purl.obolibrary.org/obo/UBERON_0001040 denotes yolk sac
T9776 14641-14645 http://purl.obolibrary.org/obo/UBERON_2000084 denotes yolk
T9775 14896-14901 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9774 14623-14628 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9773 14531-14536 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9772 14127-14132 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9023 13247-13252 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9022 12939-12944 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9021 12816-12821 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9020 12712-12719 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T7140 11152-11157 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T7139 10983-10988 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T4426 1229-1234 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T4425 1875-1881 http://purl.obolibrary.org/obo/UBERON_0002107 denotes livers
T4424 1749-1755 http://purl.obolibrary.org/obo/UBERON_0002107 denotes livers
T4423 510-516 http://purl.obolibrary.org/obo/UBERON_0002107 denotes livers

GO-BP

Id Subject Object Predicate Lexical cue
T9800 14779-14804 http://purl.obolibrary.org/obo/GO_0060319 denotes primitive, erythropoiesis
T9799 14862-14868 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9798 14117-14123 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9797 14996-15010 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T9796 14790-14804 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T9795 14509-14523 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T9794 14234-14248 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T9793 14038-14052 http://purl.obolibrary.org/obo/GO_0030218 denotes Erythropoiesis
T9792 14985-15010 http://purl.obolibrary.org/obo/GO_0060318 denotes definitive erythropoiesis
T9791 14498-14523 http://purl.obolibrary.org/obo/GO_0060318 denotes definitive erythropoiesis
T9790 14223-14248 http://purl.obolibrary.org/obo/GO_0060318 denotes definitive erythropoiesis
T9789 14027-14052 http://purl.obolibrary.org/obo/GO_0060318 denotes Definitive Erythropoiesis
T9039 12846-12860 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T5610 2823-2830 http://purl.obolibrary.org/obo/GO_0005344 denotes globins
T5609 3463-3478 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T5608 2661-2676 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T5607 2543-2558 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T5606 2533-2558 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA, not transcriptional
T10355 16760-16775 http://purl.obolibrary.org/obo/GO_0048469 denotes cell maturation
T10354 16727-16733 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T10353 16153-16167 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T9038 12835-12860 http://purl.obolibrary.org/obo/GO_0060318 denotes definitive erythropoiesis
T9037 13017-13023 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9036 12773-12779 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9035 12684-12690 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9034 12611-12617 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9033 12524-12530 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9032 12367-12373 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9031 12236-12242 http://purl.obolibrary.org/obo/GO_0005344 denotes Globin
T7168 9842-9849 http://purl.obolibrary.org/obo/GO_0005344 denotes globins
T7167 8814-8825 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T7166 8800-8813 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4445 1287-1293 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4444 1077-1083 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4443 1004-1010 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4442 869-875 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4441 468-474 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4440 90-96 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4439 48-54 http://purl.obolibrary.org/obo/GO_0005344 denotes Globin

GO-MF

Id Subject Object Predicate Lexical cue
T7275 9055-9062 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7289 9842-9849 http://purl.obolibrary.org/obo/GO_0005344 denotes globins
T7288 11121-11129 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T7287 11026-11034 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T7286 9454-9464 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T7285 11327-11334 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7284 10584-10591 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7283 10385-10392 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7282 10308-10315 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7281 10233-10240 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7280 10103-10110 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7279 10017-10024 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7278 9965-9972 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7277 9506-9513 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7276 9189-9196 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T4493 1287-1293 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4492 1077-1083 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4491 1004-1010 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4490 869-875 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4489 468-474 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4488 90-96 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T4487 48-54 http://purl.obolibrary.org/obo/GO_0005344 denotes Globin
T9831 14862-14868 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9830 14117-14123 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T5697 5786-5793 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5696 5347-5354 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5695 5343-5361 http://purl.obolibrary.org/obo/GO_0050692 denotes DNA binding domain
T5694 5343-5354 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T5693 2823-2830 http://purl.obolibrary.org/obo/GO_0005344 denotes globins
T10363 16727-16733 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9092 13017-13023 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9091 12773-12779 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9090 12684-12690 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9089 12611-12617 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9088 12524-12530 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9087 12367-12373 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T9086 12236-12242 http://purl.obolibrary.org/obo/GO_0005344 denotes Globin

GO-CC

Id Subject Object Predicate Lexical cue
T10367 16760-16764 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10366 16559-16564 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10365 16390-16395 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10364 16225-16230 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9834 14641-14645 http://purl.obolibrary.org/obo/GO_0060417 denotes yolk
T9833 14902-14907 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9832 14161-14166 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9093 13216-13221 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7304 10860-10869 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T7303 11158-11163 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7302 11142-11147 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7301 10989-10994 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7300 10969-10974 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7299 10466-10471 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7298 9916-9921 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7297 9783-9788 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7296 9723-9728 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7295 11121-11129 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T7294 11026-11034 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T7293 9454-9464 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T7292 11121-11129 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T7291 11026-11034 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T7290 9454-9464 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T5700 5025-5030 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5699 3114-3119 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5698 2743-2748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T10352 16670-16776 Sentence denotes These observations suggest that besides silencing the ɛy globin gene, Sox6 may affect red cell maturation.
T10351 16623-16669 Sentence denotes This alteration is noted as early as 14.5 dpc.
T10350 16473-16622 Sentence denotes In addition, the mutant liver shows a significant increase in hematopoietic precursor cells including nucleated erythrocytes at 18.5 dpc (Figure 7B).
T10349 16318-16472 Sentence denotes However, at postnatal day 10.5, we do not see circulating nucleated red cells in either WT or mutant mice, suggesting that this may be a transient effect.
T10348 16121-16317 Sentence denotes Among the other Sox6 effects in erythropoiesis, we have noticed that there are more nucleated red blood cells circulating in p100H mutant mice than in WT mice at 14.5 dpc and 18.5 dpc (Figure 7A).
T10347 16060-16120 Sentence denotes Mutant p100H Mice Have Higher Numbers of Nucleated Red Cells
T9788 14806-15011 Sentence denotes These data, taken together with the observation that ɛy globin is highly expressed in the liver cells of 14.5-dpc p100H mutant mice (Figure 5), demonstrate that Sox6 functions in definitive erythropoiesis.
T9787 14688-14805 Sentence denotes Therefore, Sox6 expression is temporally and spatially coincident with definitive, but not primitive, erythropoiesis.
T9786 14538-14687 Sentence denotes Furthermore, in situ hybridization shows that Sox6 is highly transcribed in 12.5-dpc liver, but not in yolk sac blood islands at 7.5 dpc (Figure 6B).
T9785 14378-14537 Sentence denotes As shown in Figure 6A, Sox6 is detectable by Northern blot beginning at 10.5 dpc, coincident with the temporal onset of definitive erythropoiesis in the liver.
T9784 14250-14377 Sentence denotes To determine the temporal and spatial expression pattern of Sox6, Northern blot and in situ hybridization assays were employed.
T9783 14053-14249 Sentence denotes The observation that Sox6-deficient mice ectopically express ɛy globin in liver, where definitive erythroid cells mature, suggests that Sox6 is an important regulator in definitive erythropoiesis.
T9782 13977-14052 Sentence denotes The Expression Pattern of Sox6 Suggests a Role in Definitive Erythropoiesis
T9030 13097-13347 Sentence denotes These data demonstrate that the persistent high levels of ɛy are due to ectopic expression in the definitive erythroid cells that mature in the fetal liver, suggesting that there is an intrinsic defect of the ɛy silencing mechanism in Sox6-null mice.
T9029 12981-13096 Sentence denotes However, the expression of βmaj/min globin is equally abundant in both WT and p100H mutant mice (Figure 5 E and F).
T9028 12875-12980 Sentence denotes In contrast, abundant ectopic ɛy mRNA expression is seen in the liver of 14.5-dpc mutants (Figure 5 A–D).
T9027 12757-12874 Sentence denotes As expected, ɛy globin is not expressed in the WT 14.5-dpc liver, the site of definitive erythropoiesis in the fetus.
T9026 12471-12756 Sentence denotes To determine whether the persistent expression of ɛy globin is due to residual primitive erythrocytes or is due to ectopic expression of ɛy globin in definitive erythrocytes, we examined the spatial pattern of ɛy globin transcripts in mouse embryos by in situ hybridization (Figure 5).
T9025 12350-12470 Sentence denotes Normally, the ɛy globin gene is exclusively expressed in primitive erythrocytes and silenced in definitive erythrocytes.
T9024 12204-12349 Sentence denotes The Persistent Expression of ɛy Globin in Sox6-Deficient Mice Is Due to a Defect in the ɛy-Gene–Silencing Mechanism in Definitive Erythroid Cells
T7165 11220-11375 Sentence denotes The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer.
T7164 11165-11219 Sentence denotes Normal IgG was used as a negative control (Figure 4A).
T7163 11036-11164 Sentence denotes Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells.
T7162 10909-11035 Sentence denotes The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody.
T7161 10793-10908 Sentence denotes We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4).
T7160 10697-10792 Sentence denotes Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree.
T7159 10473-10696 Sentence denotes Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F).
T7158 10242-10472 Sentence denotes To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells.
T7157 10183-10241 Sentence denotes The M2 mutant probe may compete partially with WT binding.
T7156 10073-10182 Sentence denotes Ablation of putative Sox/Sox6 binding sites (M1 and M3) abolish their ability to compete in EMSA (Figure 3E).
T5605 5725-5816 Sentence denotes Analysis of this short region reveals two Sox/Sox6 consensus binding sites [5] (Figure 3A).
T5604 5564-5724 Sentence denotes Deletion analysis of the ɛy promoter, as shown in Figure 2C, defined a region (−63 to −37) within the ɛy proximal promoter that is critical for Sox6 repression.
T5603 5363-5563 Sentence denotes However, this mutant version of Sox6 retains the ability to repress the ɛy promoter in the transfection assay (Figure 2B), indicating that Sox6 represses the ɛy promoter in a CtBP2-independent manner.
T5602 5302-5362 Sentence denotes This amino acid change is not in the HMG DNA binding domain.
T5601 5051-5301 Sentence denotes To investigate whether the interaction with CtBP2 is required for Sox6 repression of the ɛy promoter, we introduced a point mutation (L386H) in the Sox6 protein that has been previously reported to be sufficient to abolish Sox6-CtBP2 interaction [5].
T5600 4997-5050 Sentence denotes CtBP2 is expressed in GM979 cells (unpublished data).
T5599 4867-4996 Sentence denotes Sox6 has been shown to act as a repressor and to interact with a widely expressed co-repressor, CtBP2, on the fgf-3 promoter [5].
T5598 3394-3485 Sentence denotes These data indicate that Sox6 acts to repress the ɛy promoter at the transcriptional level.
T5597 3225-3393 Sentence denotes In contrast, overexpression of a truncated Sox6 protein that lacks its HMG domain [32] (similar to the p 100H mouse allele) fails to repress E-Luc activity (Figure 2B).
T5596 3082-3224 Sentence denotes Overexpression of Sox6 in GM979 cells by transient transfection leads to a dosage-dependent repression of E-Luc reporter activity (Figure 2B).
T5595 2837-3081 Sentence denotes We generated an ɛy promoter reporter construct (E-Luc) by fusing a micro-LCR (μLCR) element (2.5 kb) [31] to the ɛy proximal promoter (2.2 kb), followed by the luciferase reporter gene, as shown in Figure 2A (detailed in Materials and Methods).
T5594 2588-2836 Sentence denotes To investigate whether Sox6 directly acts on the ɛy gene promoter at the transcriptional level, we used an in vitro transient transfection assay and GM979 cells, a murine erythroleukemic cell line that expresses both ɛy and adult beta globins [30].
T5593 2467-2587 Sentence denotes Real-time PCR assays (Figure 1) measure steady-state levels of ɛy mRNA, not transcriptional activity of the ɛy promoter.
T5592 2340-2466 Sentence denotes Transfection Studies Using GM979 Cells Indicate That Sox6 Directly Represses the ɛy Gene Promoter at the Transcriptional Level
T4438 1702-1926 Sentence denotes We note that the level of ɛy expression in the livers of 15.5 dpc and 18.5 dpc homozygous mutant mice is statistically equivalent to the level of βmaj/min expression in the livers of 15.5 dpc and 18.5 dpc homozygous WT mice.
T7155 9935-10072 Sentence denotes The intact consensus Sox/Sox6 binding sites of the DNA probe are required for the binding, as shown in the competition assay (Figure 3E).
T7154 9868-9934 Sentence denotes Sox6 directly binds to this DNA sequence in MEL cells (Figure 3D).
T7153 9779-9867 Sentence denotes MEL cells, a murine erythroleukemic cell line, express adult β globins, but not ɛy [33].
T7152 9691-9778 Sentence denotes Next, nuclear extracts from MEL cells were used in EMSA employing the same 36-bp probe.
T7151 9532-9690 Sentence denotes To rule out the possibility that the c-Myc tag itself binds to the probe, an HA-tagged Sox6 was used in another EMSA that confirmed these results (Figure 3C).
T7150 9424-9531 Sentence denotes Moreover, both c-Myc and Sox6 antibodies supershift the band, indicating that the binding is Sox6-specific.
T7149 9368-9423 Sentence denotes The 36-bp probe was shifted by the tagged Sox6 protein.
T7148 9216-9367 Sentence denotes Sox6 is able to physically associate with the 36-bp region (Figure 3B) within the ɛy promoter defined by the deletion analysis experiments (Figure 2C).
T7147 9070-9215 Sentence denotes Also included in our EMSA are three mutated probes that are, either truncated (M1), or mutated (M2 and M3) in Sox/Sox6 binding sites (Figure 3A).
T7146 9012-9069 Sentence denotes This probe contains two consensus Sox/Sox6 binding sites.
T7145 8884-9011 Sentence denotes The 36–base pair (bp) WT probe corresponds to the critical region of the ɛy promoter defined in our promoter deletion analyses.
T7144 8843-8883 Sentence denotes The probes used are listed in Figure 3A.
T7143 8606-8842 Sentence denotes To investigate whether Sox6 is directly associated with the ɛy promoter, we first performed electrophoretic mobility shift assays (EMSA) using a c-Myc-tagged Sox6 in a reticulocyte lysate-based transcription/translation in vitro system.
T7142 8455-8605 Sentence denotes Sox6 might repress the ɛy promoter, either through direct physical contact with the promoter or by regulating intermediates affecting the ɛy promoter.
T7141 8385-8454 Sentence denotes EMSA and ChIP Assays Show that Sox6 Directly Binds to the ɛy Promoter
T4437 1453-1701 Sentence denotes Because all of the assays were performed at the same time with the same internal control, the levels shown are relative levels and are thus comparable across all samples and are in agreement with previously published results for WT fetal mice [29].
T4436 1306-1452 Sentence denotes The graphs in Figure 1 illustrate real time PCR results that were performed in triplicate (standard deviation of the data is shown by error bars).
T4435 1173-1305 Sentence denotes Perinatal lethality of mutant mice (presumably from the heart defect [14]) precludes us from evaluating postnatal globin expression.
T4434 1035-1172 Sentence denotes Moreover, the expression level of adult β globin is also somewhat higher in p100H homozygous mice than in WT mice at 18.5 dpc (Figure 1).
T4433 805-1034 Sentence denotes Interestingly, the expression levels of the other two embryonic globin genes (ζ and βh1) are also higher in p100H homozygous mice, compared with WT mice, but to a much lesser extent than seen for ɛy globin at 18.5 dpc (Figure 1).
T4432 729-804 Sentence denotes No difference was seen between WT and heterozygous mice (unpublished data).
T4431 569-728 Sentence denotes As shown in Figure 1, the ɛy gene is expressed at high levels at both time points in mutant mice, in contrast to the decline in expression observed in WT mice.
T4430 400-568 Sentence denotes Real-time PCR was used to quantitate the expression levels of other globin genes in p100H mutant and WT mouse livers at two developmental stages, 15.5 dpc and 18.5 dpc.
T4429 245-399 Sentence denotes This initial observation was confirmed in an independent knock-out allele of Sox6 [13] using real-time polymerase chain reaction (PCR) (unpublished data).
T4428 83-244 Sentence denotes The ɛy globin gene was initially identified as an upregulated transcript in the p 100H mouse using subtractive hybridization to identify Sox6 downstream targets.
T4427 9-82 Sentence denotes Persistent Expression of the Embryonic Globin, ɛy, in Sox6-Deficient Mice
T55 0-7 Sentence denotes Results
T56 9-82 Sentence denotes Persistent Expression of the Embryonic Globin, ɛy, in Sox6-Deficient Mice
T57 83-244 Sentence denotes The ɛy globin gene was initially identified as an upregulated transcript in the p 100H mouse using subtractive hybridization to identify Sox6 downstream targets.
T58 245-399 Sentence denotes This initial observation was confirmed in an independent knock-out allele of Sox6 [13] using real-time polymerase chain reaction (PCR) (unpublished data).
T59 400-568 Sentence denotes Real-time PCR was used to quantitate the expression levels of other globin genes in p100H mutant and WT mouse livers at two developmental stages, 15.5 dpc and 18.5 dpc.
T60 569-728 Sentence denotes As shown in Figure 1, the ɛy gene is expressed at high levels at both time points in mutant mice, in contrast to the decline in expression observed in WT mice.
T61 729-804 Sentence denotes No difference was seen between WT and heterozygous mice (unpublished data).
T62 805-1034 Sentence denotes Interestingly, the expression levels of the other two embryonic globin genes (ζ and βh1) are also higher in p100H homozygous mice, compared with WT mice, but to a much lesser extent than seen for ɛy globin at 18.5 dpc (Figure 1).
T63 1035-1172 Sentence denotes Moreover, the expression level of adult β globin is also somewhat higher in p100H homozygous mice than in WT mice at 18.5 dpc (Figure 1).
T64 1173-1305 Sentence denotes Perinatal lethality of mutant mice (presumably from the heart defect [14]) precludes us from evaluating postnatal globin expression.
T65 1306-1452 Sentence denotes The graphs in Figure 1 illustrate real time PCR results that were performed in triplicate (standard deviation of the data is shown by error bars).
T66 1453-1701 Sentence denotes Because all of the assays were performed at the same time with the same internal control, the levels shown are relative levels and are thus comparable across all samples and are in agreement with previously published results for WT fetal mice [29].
T67 1702-1926 Sentence denotes We note that the level of ɛy expression in the livers of 15.5 dpc and 18.5 dpc homozygous mutant mice is statistically equivalent to the level of βmaj/min expression in the livers of 15.5 dpc and 18.5 dpc homozygous WT mice.
T68 1927-1966 Sentence denotes Figure 1 Real-Time PCR of Globin Genes
T69 1967-2153 Sentence denotes The levels of expression of ɛy, βh1, zeta, and βmaj/min were measured at 15.5 dpc and 18.5 dpc in homozygous WT and p100H mutant littermates by real-time PCR (see Materials and Methods).
T70 2154-2297 Sentence denotes Relative expression levels in the livers of each genotype are graphed for each globin gene (performed in triplicate and normalized with GAPDH).
T71 2298-2338 Sentence denotes Standard deviation is indicated by bars.
T72 2340-2466 Sentence denotes Transfection Studies Using GM979 Cells Indicate That Sox6 Directly Represses the ɛy Gene Promoter at the Transcriptional Level
T73 2467-2587 Sentence denotes Real-time PCR assays (Figure 1) measure steady-state levels of ɛy mRNA, not transcriptional activity of the ɛy promoter.
T74 2588-2836 Sentence denotes To investigate whether Sox6 directly acts on the ɛy gene promoter at the transcriptional level, we used an in vitro transient transfection assay and GM979 cells, a murine erythroleukemic cell line that expresses both ɛy and adult beta globins [30].
T75 2837-3081 Sentence denotes We generated an ɛy promoter reporter construct (E-Luc) by fusing a micro-LCR (μLCR) element (2.5 kb) [31] to the ɛy proximal promoter (2.2 kb), followed by the luciferase reporter gene, as shown in Figure 2A (detailed in Materials and Methods).
T76 3082-3224 Sentence denotes Overexpression of Sox6 in GM979 cells by transient transfection leads to a dosage-dependent repression of E-Luc reporter activity (Figure 2B).
T77 3225-3393 Sentence denotes In contrast, overexpression of a truncated Sox6 protein that lacks its HMG domain [32] (similar to the p 100H mouse allele) fails to repress E-Luc activity (Figure 2B).
T78 3394-3485 Sentence denotes These data indicate that Sox6 acts to repress the ɛy promoter at the transcriptional level.
T79 3486-3533 Sentence denotes Figure 2 The Effect of Sox6 on the ɛy Promoter
T80 3534-3616 Sentence denotes (A) Constructs of the ɛy promoter reporter (E-luc) and Sox6 overexpression vector.
T81 3617-3795 Sentence denotes The E-luc reporter construct consists of a 2.5-kb μLCR element, a 2.2-kb ɛy proximal promoter, and the luciferase reporter in the pGL-3 basic plasmid (see Materials and Methods).
T82 3796-3842 Sentence denotes Sox6 expression is driven by the CMV promoter.
T83 3843-3912 Sentence denotes (B) Sox6 represses ɛy promoter activity in a dosage-dependent manner.
T84 3913-4339 Sentence denotes In GM979 cells, the E-Luc ɛy promoter reporter construct was co-transfected (1) without overexpression of Sox6; (2–4) with increasing amounts of CMV-Sox6 overexpression vector; (5) with a truncated version of Sox6 that lacks its HMG domain; (6) with a mutant version of Sox6 (L386H) that has previously been shown to abolish interaction with CtBP2; or (7) with an empty reporter plasmid (without ɛy promoter and μLCR element).
T85 4340-4404 Sentence denotes (C) Promoter deletion analyses to delimit the critical sequence.
T86 4405-4730 Sentence denotes The 2.2-kb proximal promoter or deletions of it, as indicated on the left (numbering relative to +1 = the transcription start site of ɛy globin, see Materials and Methods), were engineered in reporter constructs as in (A) and were transfected along with CMV driven Sox6 to GM979 cells (see Materials and Methods for details).
T87 4731-4825 Sentence denotes The relative repression by Sox6 on the activity of the different reporter constructs is shown.
T88 4826-4866 Sentence denotes All experiments were done in triplicate.
T89 4867-4996 Sentence denotes Sox6 has been shown to act as a repressor and to interact with a widely expressed co-repressor, CtBP2, on the fgf-3 promoter [5].
T90 4997-5050 Sentence denotes CtBP2 is expressed in GM979 cells (unpublished data).
T91 5051-5301 Sentence denotes To investigate whether the interaction with CtBP2 is required for Sox6 repression of the ɛy promoter, we introduced a point mutation (L386H) in the Sox6 protein that has been previously reported to be sufficient to abolish Sox6-CtBP2 interaction [5].
T92 5302-5362 Sentence denotes This amino acid change is not in the HMG DNA binding domain.
T93 5363-5563 Sentence denotes However, this mutant version of Sox6 retains the ability to repress the ɛy promoter in the transfection assay (Figure 2B), indicating that Sox6 represses the ɛy promoter in a CtBP2-independent manner.
T94 5564-5724 Sentence denotes Deletion analysis of the ɛy promoter, as shown in Figure 2C, defined a region (−63 to −37) within the ɛy proximal promoter that is critical for Sox6 repression.
T95 5725-5816 Sentence denotes Analysis of this short region reveals two Sox/Sox6 consensus binding sites [5] (Figure 3A).
T96 5817-5912 Sentence denotes Figure 3 Analysis of the Minimal Region (36 bp) of the Proximal ɛy Promoter Responsive to Sox6
T97 5913-5989 Sentence denotes (A) The sequence of the 36-bp fragment and its mutant versions used in EMSA.
T98 5990-6135 Sentence denotes The WT 36-bp DNA sequence (−63 to −28) of the ɛy globin proximal promoter contains two Sox/Sox6 consensus binding sites, shown in bold underline.
T99 6136-6264 Sentence denotes Versions with truncation of this sequence (M1) or mutation of one of the two consensus binding sites (M2 and M3) are also shown.
T100 6265-6297 Sentence denotes (B) EMSA with c-Myc-tagged Sox6.
T101 6298-6470 Sentence denotes EMSA was performed using the 36-bp radio-labeled WT probe (as shown in (A)) and c-Myc tagged Sox6 translated in vitro using reticulocyte lysate (see Materials and Methods).
T102 6471-6856 Sentence denotes Lane 1: radio-labeled free probe (run out of the gel); Lane 2: no competition, no antibody; Lane 3: competition with 200-fold excess cold probe, no antibody; Lane 4: no competition, c-Myc antibody (producing a supershift); Lane 5: no competition, Sox6 antibody (producing a supershift); Lane 6: no competion, no antibody using in vitro translated vector containing c-Myc, but not Sox6.
T103 6857-6886 Sentence denotes (C) EMSA with HA-tagged Sox6.
T104 6887-6967 Sentence denotes EMSA was performed similarly as in (B) using HA-tagged Sox6 translated in vitro.
T105 6968-7187 Sentence denotes Lane 1: radio-labeled free probe (run out of the gel); Lane 2: no competition, no antibody; Lane 3: competition with 200-fold excess cold probe, no antibody; Lane 4: no competition, HA antibody (producing a supershift).
T106 7188-7252 Sentence denotes (D) EMSA using MEL cell nuclear extracts and the 36-bp WT probe.
T107 7253-7474 Sentence denotes Lane 1: radio-labeled free probe (run out of the gel); Lane 2: no competition, no antibody; Lane 3: competition with 200-fold excess cold probe, no antibody; Lane 4: no competition, Sox6 antibody (producing a supershift).
T108 7475-7568 Sentence denotes (E) EMSA with c-Myc-tagged Sox6, WT and mutant versions of the 36-bp fragment in competition.
T109 7569-7673 Sentence denotes EMSA was performed using the radio-labeled 36-bp WT probe and the c-Myc tagged Sox6 translated in vitro.
T110 7674-7744 Sentence denotes Lane 1: radio-labeled free probe; Lane 2: no competition, no antibody.
T111 7745-7877 Sentence denotes Competition was performed using 200-fold excess cold probes corresponding to WT (Lane 3), M1 (Lane 4), M2 (Lane 5), and M3 (Lane 6).
T112 7878-7957 Sentence denotes (F) Both consensus Sox/Sox6 binding sites are required for Sox6 responsiveness.
T113 7958-8124 Sentence denotes GM979 cells were transfected with a reporter construct (Figure 2A) containing −63 to +45 of the ɛy proximal promoter together with the CMV-Sox6 overexpression vector.
T114 8125-8213 Sentence denotes Mutations of the consensus binding sites were also tested (M3, M2, M2 plus M3, see (A)).
T115 8214-8284 Sentence denotes The fold repression of Sox6 with the WT or mutant constructs is shown.
T116 8285-8383 Sentence denotes The baseline activities of the mutagenized reporter constructs are comparable to the WT construct.
T117 8385-8454 Sentence denotes EMSA and ChIP Assays Show that Sox6 Directly Binds to the ɛy Promoter
T118 8455-8605 Sentence denotes Sox6 might repress the ɛy promoter, either through direct physical contact with the promoter or by regulating intermediates affecting the ɛy promoter.
T119 8606-8842 Sentence denotes To investigate whether Sox6 is directly associated with the ɛy promoter, we first performed electrophoretic mobility shift assays (EMSA) using a c-Myc-tagged Sox6 in a reticulocyte lysate-based transcription/translation in vitro system.
T120 8843-8883 Sentence denotes The probes used are listed in Figure 3A.
T121 8884-9011 Sentence denotes The 36–base pair (bp) WT probe corresponds to the critical region of the ɛy promoter defined in our promoter deletion analyses.
T122 9012-9069 Sentence denotes This probe contains two consensus Sox/Sox6 binding sites.
T123 9070-9215 Sentence denotes Also included in our EMSA are three mutated probes that are, either truncated (M1), or mutated (M2 and M3) in Sox/Sox6 binding sites (Figure 3A).
T124 9216-9367 Sentence denotes Sox6 is able to physically associate with the 36-bp region (Figure 3B) within the ɛy promoter defined by the deletion analysis experiments (Figure 2C).
T125 9368-9423 Sentence denotes The 36-bp probe was shifted by the tagged Sox6 protein.
T126 9424-9531 Sentence denotes Moreover, both c-Myc and Sox6 antibodies supershift the band, indicating that the binding is Sox6-specific.
T127 9532-9690 Sentence denotes To rule out the possibility that the c-Myc tag itself binds to the probe, an HA-tagged Sox6 was used in another EMSA that confirmed these results (Figure 3C).
T128 9691-9778 Sentence denotes Next, nuclear extracts from MEL cells were used in EMSA employing the same 36-bp probe.
T129 9779-9867 Sentence denotes MEL cells, a murine erythroleukemic cell line, express adult β globins, but not ɛy [33].
T130 9868-9934 Sentence denotes Sox6 directly binds to this DNA sequence in MEL cells (Figure 3D).
T131 9935-10072 Sentence denotes The intact consensus Sox/Sox6 binding sites of the DNA probe are required for the binding, as shown in the competition assay (Figure 3E).
T132 10073-10182 Sentence denotes Ablation of putative Sox/Sox6 binding sites (M1 and M3) abolish their ability to compete in EMSA (Figure 3E).
T133 10183-10241 Sentence denotes The M2 mutant probe may compete partially with WT binding.
T134 10242-10472 Sentence denotes To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells.
T135 10473-10696 Sentence denotes Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F).
T136 10697-10792 Sentence denotes Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree.
T137 10793-10908 Sentence denotes We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4).
T138 10909-11035 Sentence denotes The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody.
T139 11036-11164 Sentence denotes Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells.
T140 11165-11219 Sentence denotes Normal IgG was used as a negative control (Figure 4A).
T141 11220-11375 Sentence denotes The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer.
T142 11376-11396 Sentence denotes Figure 4 ChIP Assay
T143 11397-11496 Sentence denotes MEL cells (A) and 15.5-dpc fetal liver cells (B) were treated as detailed in Materials and Methods.
T144 11497-11718 Sentence denotes 10% of the sample was saved as total input (Inp); remaining samples were divided: plus Sox6 antibody (Ab+), minus Sox6 antibody (Ab−), as well as no DNA (DNA−) and normal rabbit IgG (IgG) that served as negative controls.
T145 11719-11838 Sentence denotes Other controls for these experiments included PCR within the promoter of the α-globin gene and intron 24 of the p gene.
T146 11839-11877 Sentence denotes Both were negative (unpublished data).
T147 11878-12008 Sentence denotes PCR was carried out using primer pairs flanking the Sox/Sox6 binding sites (see Material and Methods) of the ɛy proximal promoter.
T148 12009-12098 Sentence denotes For all reactions, we used 2 μl of immuno-precipitated DNA and 2 μl of 1/100 total input.
T149 12099-12158 Sentence denotes Semiquantitative PCR was done within the exponential range.
T150 12159-12202 Sentence denotes Multiple independent experiments were done.
T151 12204-12349 Sentence denotes The Persistent Expression of ɛy Globin in Sox6-Deficient Mice Is Due to a Defect in the ɛy-Gene–Silencing Mechanism in Definitive Erythroid Cells
T152 12350-12470 Sentence denotes Normally, the ɛy globin gene is exclusively expressed in primitive erythrocytes and silenced in definitive erythrocytes.
T153 12471-12756 Sentence denotes To determine whether the persistent expression of ɛy globin is due to residual primitive erythrocytes or is due to ectopic expression of ɛy globin in definitive erythrocytes, we examined the spatial pattern of ɛy globin transcripts in mouse embryos by in situ hybridization (Figure 5).
T154 12757-12874 Sentence denotes As expected, ɛy globin is not expressed in the WT 14.5-dpc liver, the site of definitive erythropoiesis in the fetus.
T155 12875-12980 Sentence denotes In contrast, abundant ectopic ɛy mRNA expression is seen in the liver of 14.5-dpc mutants (Figure 5 A–D).
T156 12981-13096 Sentence denotes However, the expression of βmaj/min globin is equally abundant in both WT and p100H mutant mice (Figure 5 E and F).
T157 13097-13347 Sentence denotes These data demonstrate that the persistent high levels of ɛy are due to ectopic expression in the definitive erythroid cells that mature in the fetal liver, suggesting that there is an intrinsic defect of the ɛy silencing mechanism in Sox6-null mice.
T158 13348-13450 Sentence denotes Figure 5 In Situ Hybridization of ɛy and βmaj/min transcripts in WT and p100H Mutant Mice at 14.5 dpc
T159 13451-13575 Sentence denotes Expression of ɛy globin (A–D) and β globin (E and F) in sagittal sections of 14.5-dpc fetuses is shown in pseudocolor (red).
T160 13576-13589 Sentence denotes (A) WT fetus.
T161 13590-13624 Sentence denotes (B) p100H Homozygous mutant fetus.
T162 13625-13657 Sentence denotes (C and D) Inset boxes are shown.
T163 13658-13737 Sentence denotes Prominent expression of ɛy globin is only detected in the liver of mutant mice.
T164 13738-13830 Sentence denotes (E and F) In contrast, both WT and mutant mouse livers express adult βmaj/min, respectively.
T165 13831-13911 Sentence denotes No signals were detected above background using sense probes (unpublished data).
T166 13912-13975 Sentence denotes The size bars represent 1 mm for (A) and (B); 100 μm for (C–F).
T167 13977-14052 Sentence denotes The Expression Pattern of Sox6 Suggests a Role in Definitive Erythropoiesis
T168 14053-14249 Sentence denotes The observation that Sox6-deficient mice ectopically express ɛy globin in liver, where definitive erythroid cells mature, suggests that Sox6 is an important regulator in definitive erythropoiesis.
T169 14250-14377 Sentence denotes To determine the temporal and spatial expression pattern of Sox6, Northern blot and in situ hybridization assays were employed.
T170 14378-14537 Sentence denotes As shown in Figure 6A, Sox6 is detectable by Northern blot beginning at 10.5 dpc, coincident with the temporal onset of definitive erythropoiesis in the liver.
T171 14538-14687 Sentence denotes Furthermore, in situ hybridization shows that Sox6 is highly transcribed in 12.5-dpc liver, but not in yolk sac blood islands at 7.5 dpc (Figure 6B).
T172 14688-14805 Sentence denotes Therefore, Sox6 expression is temporally and spatially coincident with definitive, but not primitive, erythropoiesis.
T173 14806-15011 Sentence denotes These data, taken together with the observation that ɛy globin is highly expressed in the liver cells of 14.5-dpc p100H mutant mice (Figure 5), demonstrate that Sox6 functions in definitive erythropoiesis.
T174 15012-15084 Sentence denotes Figure 6 Expression Pattern of Sox6 by Northern Blot and In Situ Assays
T175 15085-15157 Sentence denotes (A) Sox6 expression during embryonic development shown by Northern blot.
T176 15158-15254 Sentence denotes Each lane contains 20 μg of total RNA from embryos whose ages are listed above each lane as dpc.
T177 15255-15356 Sentence denotes The filter was hybridized with a 32P-labeled 575-bp mouse Sox6 cDNA fragment (nucleotides 1353–1927).
T178 15357-15422 Sentence denotes Numbers on the left are sizes of standard marker fragments in kb.
T179 15423-15474 Sentence denotes (B) Sox6 expression shown by in situ hybridization.
T180 15475-15483 Sentence denotes Panel i:
T181 15484-15658 Sentence denotes Sagittal section through an E12.5 mouse embryo using antisense Sox6. mRNA distribution is represented by pseudocolored red signal superimposed on the counterstained specimen.
T182 15659-15781 Sentence denotes Sox6 transcripts are detected primarily in the fetal liver, developing nervous system, chondrocytes and craniofacial area.
T183 15782-15791 Sentence denotes Panel ii:
T184 15792-15849 Sentence denotes The sense control probe shows no signal above background.
T185 15850-15912 Sentence denotes Panel iii: E7.5 embryo hybridized to antisense probe for Sox6.
T186 15913-16026 Sentence denotes No signal is detected above background specifically in blood islands (or with the sense probe, unpublished data).
T187 16027-16058 Sentence denotes The size bars represent 100 μm.
T188 16060-16120 Sentence denotes Mutant p100H Mice Have Higher Numbers of Nucleated Red Cells
T189 16121-16317 Sentence denotes Among the other Sox6 effects in erythropoiesis, we have noticed that there are more nucleated red blood cells circulating in p100H mutant mice than in WT mice at 14.5 dpc and 18.5 dpc (Figure 7A).
T190 16318-16472 Sentence denotes However, at postnatal day 10.5, we do not see circulating nucleated red cells in either WT or mutant mice, suggesting that this may be a transient effect.
T191 16473-16622 Sentence denotes In addition, the mutant liver shows a significant increase in hematopoietic precursor cells including nucleated erythrocytes at 18.5 dpc (Figure 7B).
T192 16623-16669 Sentence denotes This alteration is noted as early as 14.5 dpc.
T193 16670-16776 Sentence denotes These observations suggest that besides silencing the ɛy globin gene, Sox6 may affect red cell maturation.
T194 16777-16848 Sentence denotes Figure 7 The Blood and Liver Phenotype of WT and p100H Homozygous Mice
T195 16849-16967 Sentence denotes (A) Red blood cells of WT mice (left panels) and p100H homozygous mice (right panels) are shown at the indicated ages.
T196 16968-17082 Sentence denotes (B) Liver cells of WT mice (left panels) and p100H homozygous mice (right panels) are shown at the indicated ages.

simple1

Id Subject Object Predicate Lexical cue
T10370 16740-16744 Protein denotes Sox6
T10369 16724-16733 Protein denotes ɛy globin
T10368 16137-16141 Protein denotes Sox6
T9861 14967-14971 Protein denotes Sox6
T9860 14859-14868 Protein denotes ɛy globin
T9859 14699-14703 Protein denotes Sox6
T9858 14584-14588 Protein denotes Sox6
T9857 14401-14405 Protein denotes Sox6
T9856 14310-14314 Protein denotes Sox6
T9855 14189-14193 Protein denotes Sox6
T9854 14114-14123 Protein denotes ɛy globin
T9853 14074-14078 Protein denotes Sox6
T9852 14003-14007 Protein denotes Sox6
T9128 13332-13336 Protein denotes Sox6
T9127 13306-13308 Protein denotes ɛy
T9126 13155-13157 Protein denotes ɛy
T9125 13013-13023 Protein denotes min globin
T9124 13008-13012 Protein denotes βmaj
T9123 12905-12907 Protein denotes ɛy
T9122 12770-12779 Protein denotes ɛy globin
T9121 12681-12690 Protein denotes ɛy globin
T9120 12608-12617 Protein denotes ɛy globin
T9119 12521-12530 Protein denotes ɛy globin
T9118 12364-12373 Protein denotes ɛy globin
T9117 12292-12294 Protein denotes ɛy
T9116 12246-12250 Protein denotes Sox6
T9115 12233-12242 Protein denotes ɛy Globin
T7432 11342-11344 Protein denotes ɛy
T7431 11307-11309 Protein denotes ɛy
T7430 11275-11279 Protein denotes Sox6
T7429 11116-11120 Protein denotes Sox6
T7428 11060-11062 Protein denotes ɛy
T7427 11021-11025 Protein denotes Sox6
T7426 10913-10917 Protein denotes Sox6
T7425 10834-10836 Protein denotes ɛy
T7424 10816-10820 Protein denotes Sox6
T7423 10759-10763 Protein denotes Sox6
T7422 10753-10755 Protein denotes ɛy
T7421 10518-10520 Protein denotes ɛy
T7420 10428-10432 Protein denotes Sox6
T7419 10327-10329 Protein denotes ɛy
T7418 9868-9872 Protein denotes Sox6
T7417 9859-9861 Protein denotes ɛy
T7416 9840-9849 Protein denotes β globins
T7415 9619-9623 Protein denotes Sox6
T7414 9609-9611 Protein denotes HA
T7413 9569-9574 Protein denotes c-Myc
T7412 9517-9521 Protein denotes Sox6
T7411 9449-9453 Protein denotes Sox6
T7410 9439-9444 Protein denotes c-Myc
T7409 9410-9414 Protein denotes Sox6
T7408 9298-9300 Protein denotes ɛy
T7407 9216-9220 Protein denotes Sox6
T7406 8957-8959 Protein denotes ɛy
T7405 8764-8768 Protein denotes Sox6
T7404 8751-8756 Protein denotes c-Myc
T7403 8666-8668 Protein denotes ɛy
T7402 8629-8633 Protein denotes Sox6
T7401 8593-8595 Protein denotes ɛy
T7400 8478-8480 Protein denotes ɛy
T7399 8455-8459 Protein denotes Sox6
T7398 8443-8445 Protein denotes ɛy
T7397 8416-8420 Protein denotes Sox6
T5815 5708-5712 Protein denotes Sox6
T5814 5666-5668 Protein denotes ɛy
T5813 5589-5591 Protein denotes ɛy
T5812 5538-5543 Protein denotes CtBP2
T5811 5521-5523 Protein denotes ɛy
T5810 5502-5506 Protein denotes Sox6
T5809 5435-5437 Protein denotes ɛy
T5808 5395-5399 Protein denotes Sox6
T5807 5279-5284 Protein denotes CtBP2
T5806 5274-5278 Protein denotes Sox6
T5805 5199-5203 Protein denotes Sox6
T5804 5140-5142 Protein denotes ɛy
T5803 5117-5121 Protein denotes Sox6
T5802 5095-5100 Protein denotes CtBP2
T5801 4997-5002 Protein denotes CtBP2
T5800 4977-4982 Protein denotes fgf-3
T5799 4963-4968 Protein denotes CtBP2
T5798 4867-4871 Protein denotes Sox6
T5797 3444-3446 Protein denotes ɛy
T5796 3419-3423 Protein denotes Sox6
T5795 3268-3272 Protein denotes Sox6
T5794 3100-3104 Protein denotes Sox6
T5793 2997-3007 Protein denotes luciferase
T5792 2950-2952 Protein denotes ɛy
T5791 2853-2855 Protein denotes ɛy
T5790 2818-2830 Protein denotes beta globins
T5789 2805-2807 Protein denotes ɛy
T5788 2637-2639 Protein denotes ɛy
T5787 2611-2615 Protein denotes Sox6
T5786 2575-2577 Protein denotes ɛy
T5785 2530-2532 Protein denotes ɛy
T5784 2421-2423 Protein denotes ɛy
T5783 2393-2397 Protein denotes Sox6
T4526 1853-1856 Protein denotes min
T4525 1848-1852 Protein denotes βmaj
T4524 1728-1730 Protein denotes ɛy
T4523 1075-1083 Protein denotes β globin
T4522 1001-1010 Protein denotes ɛy globin
T4521 889-892 Protein denotes βh1
T4520 883-884 Protein denotes ζ
T4519 595-597 Protein denotes ɛy
T4518 322-326 Protein denotes Sox6
T4517 220-224 Protein denotes Sox6
T4516 87-96 Protein denotes ɛy globin
T4515 63-67 Protein denotes Sox6
T4514 56-58 Protein denotes ɛy
T4513 48-54 Protein denotes Globin

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T10681 16710-16719 Negative_regulation denotes silencing
T10680 16740-16744 Protein denotes Sox6
T10679 16724-16733 Protein denotes ɛy globin
T10678 16137-16141 Protein denotes Sox6
T10321 14879-14888 Gene_expression denotes expressed
T10320 14704-14714 Gene_expression denotes expression
T10319 14599-14610 Transcription denotes transcribed
T10318 14288-14298 Gene_expression denotes expression
T10317 14106-14113 Gene_expression denotes express
T10316 14079-14088 Negative_regulation denotes deficient
T10315 13981-13991 Gene_expression denotes Expression
T10314 14859-14868 Protein denotes ɛy globin
T10313 14967-14971 Protein denotes Sox6
T10312 14699-14703 Protein denotes Sox6
T10311 14584-14588 Protein denotes Sox6
T10310 14401-14405 Protein denotes Sox6
T10309 14310-14314 Protein denotes Sox6
T10308 14189-14193 Protein denotes Sox6
T10307 14114-14123 Protein denotes ɛy globin
T10306 14074-14078 Protein denotes Sox6
T10305 14003-14007 Protein denotes Sox6
T9712 13292-13298 Negative_regulation denotes defect
T9711 13177-13187 Gene_expression denotes expression
T9710 13337-13341 Negative_regulation denotes null
T9709 12994-13004 Gene_expression denotes expression
T9708 12913-12923 Transcription denotes expression
T9707 12787-12796 Gene_expression denotes expressed
T9706 12507-12517 Gene_expression denotes expression
T9705 12579-12582 Positive_regulation denotes due
T9704 12594-12604 Gene_expression denotes expression
T9703 12394-12403 Gene_expression denotes expressed
T9702 12434-12442 Negative_regulation denotes silenced
T9701 12251-12260 Negative_regulation denotes Deficient
T9700 12219-12229 Gene_expression denotes Expression
T9699 13332-13336 Protein denotes Sox6
T9698 13306-13308 Protein denotes ɛy
T9697 13155-13157 Protein denotes ɛy
T9696 13013-13023 Protein denotes min globin
T9695 13008-13012 Protein denotes βmaj
T9694 12905-12907 Protein denotes ɛy
T9693 12770-12779 Protein denotes ɛy globin
T9692 12681-12690 Protein denotes ɛy globin
T9691 12608-12617 Protein denotes ɛy globin
T9690 12521-12530 Protein denotes ɛy globin
T9689 12364-12373 Protein denotes ɛy globin
T9688 12292-12294 Protein denotes ɛy
T9687 12246-12250 Protein denotes Sox6
T9686 12233-12242 Protein denotes ɛy Globin
T8910 11290-11299 Negative_regulation denotes repressor
T8909 11327-11334 Binding denotes binding
T8908 11092-11110 Binding denotes immunoprecipitated
T8907 10821-10826 Binding denotes binds
T8906 10739-10749 Negative_regulation denotes repression
T8905 10718-10726 Positive_regulation denotes required
T8904 10433-10447 Gene_expression denotes overexpression
T8903 9882-9887 Binding denotes binds
T8902 9826-9833 Gene_expression denotes express
T8901 9586-9591 Binding denotes binds
T8900 9243-9252 Binding denotes associate
T8899 8646-8656 Binding denotes associated
T8898 8554-8564 Regulation denotes regulating
T8897 8579-8588 Regulation denotes affecting
T8896 8466-8473 Negative_regulation denotes repress
T8895 8430-8435 Binding denotes Binds
T8894 11342-11344 Protein denotes ɛy
T8893 11307-11309 Protein denotes ɛy
T8892 11275-11279 Protein denotes Sox6
T8891 11116-11120 Protein denotes Sox6
T8890 11060-11062 Protein denotes ɛy
T8889 11021-11025 Protein denotes Sox6
T8888 10913-10917 Protein denotes Sox6
T8887 10834-10836 Protein denotes ɛy
T8886 10816-10820 Protein denotes Sox6
T8885 10759-10763 Protein denotes Sox6
T8884 10753-10755 Protein denotes ɛy
T8883 10518-10520 Protein denotes ɛy
T8882 10428-10432 Protein denotes Sox6
T8881 10327-10329 Protein denotes ɛy
T8880 9868-9872 Protein denotes Sox6
T8879 9859-9861 Protein denotes ɛy
T8878 9840-9849 Protein denotes β globins
T8877 9619-9623 Protein denotes Sox6
T8876 9609-9611 Protein denotes HA
T8875 9569-9574 Protein denotes c-Myc
T8874 9517-9521 Protein denotes Sox6
T8873 9449-9453 Protein denotes Sox6
T8872 9439-9444 Protein denotes c-Myc
T8871 9410-9414 Protein denotes Sox6
T8870 9298-9300 Protein denotes ɛy
T8869 9216-9220 Protein denotes Sox6
T8868 8957-8959 Protein denotes ɛy
T8867 8764-8768 Protein denotes Sox6
T8866 8751-8756 Protein denotes c-Myc
T8865 8666-8668 Protein denotes ɛy
T8864 8629-8633 Protein denotes Sox6
T8863 8593-8595 Protein denotes ɛy
T8862 8478-8480 Protein denotes ɛy
T8861 8455-8459 Protein denotes Sox6
T8860 8443-8445 Protein denotes ɛy
T8859 8416-8420 Protein denotes Sox6
T6932 5713-5723 Negative_regulation denotes repression
T6931 5507-5516 Negative_regulation denotes represses
T6930 5423-5430 Negative_regulation denotes repress
T6929 5078-5089 Binding denotes interaction
T6928 5122-5132 Negative_regulation denotes repression
T6927 5285-5296 Binding denotes interaction
T6926 5266-5273 Negative_regulation denotes abolish
T6925 5104-5112 Positive_regulation denotes required
T6924 5006-5015 Gene_expression denotes expressed
T6923 4939-4948 Gene_expression denotes expressed
T6922 4916-4924 Binding denotes interact
T6921 3432-3439 Negative_regulation denotes repress
T6920 3238-3252 Gene_expression denotes overexpression
T6919 3238-3252 Positive_regulation denotes overexpression
T6918 3082-3096 Positive_regulation denotes Overexpression
T6917 3082-3096 Gene_expression denotes Overexpression
T6916 2625-2629 Positive_regulation denotes acts
T6915 2790-2799 Gene_expression denotes expresses
T6914 5708-5712 Protein denotes Sox6
T6913 5666-5668 Protein denotes ɛy
T6912 5589-5591 Protein denotes ɛy
T6911 5538-5543 Protein denotes CtBP2
T6910 5521-5523 Protein denotes ɛy
T6909 5502-5506 Protein denotes Sox6
T6908 5435-5437 Protein denotes ɛy
T6907 5395-5399 Protein denotes Sox6
T6906 5279-5284 Protein denotes CtBP2
T6905 5274-5278 Protein denotes Sox6
T6904 5199-5203 Protein denotes Sox6
T6903 5140-5142 Protein denotes ɛy
T6902 5117-5121 Protein denotes Sox6
T6901 5095-5100 Protein denotes CtBP2
T6900 4997-5002 Protein denotes CtBP2
T6899 4977-4982 Protein denotes fgf-3
T6898 4963-4968 Protein denotes CtBP2
T6897 4867-4871 Protein denotes Sox6
T6896 3444-3446 Protein denotes ɛy
T6895 3419-3423 Protein denotes Sox6
T6894 3268-3272 Protein denotes Sox6
T6893 3100-3104 Protein denotes Sox6
T6892 2853-2855 Protein denotes ɛy
T6891 2997-3007 Protein denotes luciferase
T6890 2950-2952 Protein denotes ɛy
T6889 2818-2830 Protein denotes beta globins
T6888 2805-2807 Protein denotes ɛy
T6887 2637-2639 Protein denotes ɛy
T6886 2611-2615 Protein denotes Sox6
T6885 2575-2577 Protein denotes ɛy
T6884 2530-2532 Protein denotes ɛy
T6883 2421-2423 Protein denotes ɛy
T6882 2393-2397 Protein denotes Sox6
T5425 1731-1741 Gene_expression denotes expression
T5424 1719-1724 Negative_regulation denotes level
T5423 1857-1867 Gene_expression denotes expression
T5422 1049-1059 Gene_expression denotes expression
T5421 903-909 Positive_regulation denotes higher
T5420 824-834 Gene_expression denotes expression
T5419 606-615 Gene_expression denotes expressed
T5418 133-144 Positive_regulation denotes upregulated
T5417 236-243 Regulation denotes targets
T5416 68-77 Negative_regulation denotes Deficient
T5415 20-30 Gene_expression denotes Expression
T5414 1853-1856 Protein denotes min
T5413 1848-1852 Protein denotes βmaj
T5412 1728-1730 Protein denotes ɛy
T5411 1075-1083 Protein denotes β globin
T5410 889-892 Protein denotes βh1
T5409 883-884 Protein denotes ζ
T5408 1001-1010 Protein denotes ɛy globin
T5407 595-597 Protein denotes ɛy
T5406 322-326 Protein denotes Sox6
T5405 220-224 Protein denotes Sox6
T5404 87-96 Protein denotes ɛy globin
T5403 63-67 Protein denotes Sox6
T5402 56-58 Protein denotes ɛy
T5401 48-54 Protein denotes Globin
R3870 T5401 T5415 themeOf Globin,Expression
R3871 T5402 T5415 themeOf ɛy,Expression
R3872 T5403 T5416 themeOf Sox6,Deficient
R3873 T5404 T5418 themeOf ɛy globin,upregulated
R3874 T5405 T5417 themeOf Sox6,targets
R3875 T5407 T5419 themeOf ɛy,expressed
R3876 T5409 T5421 themeOf ζ,higher
R3877 T5409 T5420 themeOf ζ,expression
R3878 T5410 T5421 themeOf βh1,higher
R3879 T5410 T5420 themeOf βh1,expression
R3880 T5411 T5422 themeOf β globin,expression
R3881 T5412 T5425 themeOf ɛy,expression
R3882 T5413 T5423 themeOf βmaj,expression
R3883 T5414 T5423 themeOf min,expression
R3884 T5425 T5424 themeOf expression,level
R4864 T6886 T6916 causeOf Sox6,acts
R4865 T6887 T6916 themeOf ɛy,acts
R4866 T6888 T6915 themeOf ɛy,expresses
R4867 T6889 T6915 themeOf beta globins,expresses
R4868 T6893 T6917 themeOf Sox6,Overexpression
R4869 T6894 T6920 themeOf Sox6,overexpression
R4870 T6895 T6921 causeOf Sox6,repress
R4871 T6896 T6921 themeOf ɛy,repress
R4872 T6898 T6922 themeOf CtBP2,interact
R4873 T6898 T6923 themeOf CtBP2,expressed
R4874 T6899 T6922 themeOf fgf-3,interact
R4875 T6899 T6923 themeOf fgf-3,expressed
R4876 T6900 T6924 themeOf CtBP2,expressed
R4877 T6901 T6929 themeOf CtBP2,interaction
R4878 T6902 T6928 themeOf Sox6,repression
R4879 T6903 T6928 themeOf ɛy,repression
R4880 T6905 T6927 themeOf Sox6,interaction
R4881 T6906 T6927 themeOf CtBP2,interaction
R4882 T6907 T6930 causeOf Sox6,repress
R4883 T6908 T6930 themeOf ɛy,repress
R4884 T6909 T6931 causeOf Sox6,represses
R4885 T6910 T6931 themeOf ɛy,represses
R4886 T6914 T6932 themeOf Sox6,repression
R4887 T6917 T6918 themeOf Overexpression,Overexpression
R4888 T6920 T6919 themeOf overexpression,overexpression
R4889 T6927 T6926 themeOf interaction,abolish
R4890 T6927 T6926 themeOf interaction,abolish
R4891 T6928 T6925 themeOf repression,required
R4892 T6928 T6925 themeOf repression,required
R4893 T6929 T6925 causeOf interaction,required
R4894 T6929 T6925 causeOf interaction,required
R6203 T8859 T8895 themeOf Sox6,Binds
R6204 T8861 T8898 causeOf Sox6,regulating
R6205 T8862 T8896 themeOf ɛy,repress
R6206 T8863 T8897 themeOf ɛy,affecting
R6207 T8864 T8899 themeOf Sox6,associated
R6208 T8869 T8900 themeOf Sox6,associate
R6209 T8870 T8900 themeOf ɛy,associate
R6210 T8875 T8901 themeOf c-Myc,binds
R6211 T8878 T8902 themeOf β globins,express
R6212 T8880 T8903 themeOf Sox6,binds
R6213 T8882 T8904 themeOf Sox6,overexpression
R6214 T8884 T8906 themeOf ɛy,repression
R6215 T8885 T8906 causeOf Sox6,repression
R6216 T8886 T8907 themeOf Sox6,binds
R6217 T8887 T8907 themeOf ɛy,binds
R6218 T8890 T8908 themeOf ɛy,immunoprecipitated
R6219 T8892 T8909 themeOf Sox6,binding
R6220 T8893 T8910 themeOf ɛy,repressor
R6221 T8893 T8909 themeOf ɛy,binding
R6222 T8894 T8909 themeOf ɛy,binding
R6223 T8894 T8909 themeOf ɛy,binding
R6224 T8897 T8898 themeOf affecting,regulating
R6225 T8906 T8905 themeOf repression,required
R6745 T9686 T9700 themeOf ɛy Globin,Expression
R6746 T9687 T9701 themeOf Sox6,Deficient
R6747 T9689 T9702 themeOf ɛy globin,silenced
R6748 T9689 T9703 themeOf ɛy globin,expressed
R6749 T9690 T9706 themeOf ɛy globin,expression
R6750 T9691 T9704 themeOf ɛy globin,expression
R6751 T9693 T9707 themeOf ɛy globin,expressed
R6752 T9694 T9708 themeOf ɛy,expression
R6753 T9695 T9709 themeOf βmaj,expression
R6754 T9696 T9709 themeOf min globin,expression
R6755 T9697 T9711 themeOf ɛy,expression
R6756 T9698 T9712 themeOf ɛy,defect
R6757 T9699 T9710 themeOf Sox6,null
R6758 T9704 T9705 themeOf expression,due
R6759 T9706 T9705 themeOf expression,due
R7152 T10305 T10315 themeOf Sox6,Expression
R7153 T10306 T10316 themeOf Sox6,deficient
R7154 T10307 T10317 themeOf ɛy globin,express
R7155 T10309 T10318 themeOf Sox6,expression
R7156 T10311 T10319 themeOf Sox6,transcribed
R7157 T10312 T10320 themeOf Sox6,expression
R7158 T10314 T10321 themeOf ɛy globin,expressed
R7159 T10317 T10316 themeOf express,deficient
R7433 T10679 T10681 themeOf ɛy globin,silencing

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T10053 14879-14888 Gene_expression denotes expressed
T10052 14704-14714 Gene_expression denotes expression
T10051 14288-14298 Gene_expression denotes expression
T10050 14079-14088 Negative_regulation denotes deficient
T10049 14106-14113 Gene_expression denotes express
T10048 13981-13991 Gene_expression denotes Expression
T10047 14859-14868 Protein denotes ɛy globin
T10046 14967-14971 Protein denotes Sox6
T10045 14699-14703 Protein denotes Sox6
T10044 14584-14588 Protein denotes Sox6
T10043 14401-14405 Protein denotes Sox6
T10042 14310-14314 Protein denotes Sox6
T10041 14189-14193 Protein denotes Sox6
T10040 14114-14123 Protein denotes ɛy globin
T10039 14074-14078 Protein denotes Sox6
T10038 14003-14007 Protein denotes Sox6
T10505 16710-16719 Negative_regulation denotes silencing
T10504 16142-16149 Regulation denotes effects
T10503 16740-16744 Protein denotes Sox6
T10502 16724-16733 Protein denotes ɛy globin
T10501 16137-16141 Protein denotes Sox6
T9332 12608-12617 Protein denotes ɛy globin
T9331 12521-12530 Protein denotes ɛy globin
T9330 12364-12373 Protein denotes ɛy globin
T9329 12292-12294 Protein denotes ɛy
T9328 12246-12250 Protein denotes Sox6
T9327 12233-12242 Protein denotes ɛy Globin
T9352 13177-13187 Gene_expression denotes expression
T9351 13292-13298 Negative_regulation denotes defect
T9350 13337-13341 Negative_regulation denotes null
T9349 12994-13004 Gene_expression denotes expression
T9348 12913-12923 Transcription denotes expression
T9347 12787-12796 Gene_expression denotes expressed
T9346 12507-12517 Gene_expression denotes expression
T9345 12594-12604 Gene_expression denotes expression
T9344 12579-12582 Positive_regulation denotes due
T9343 12394-12403 Gene_expression denotes expressed
T9342 12251-12260 Negative_regulation denotes Deficient
T9341 12219-12229 Gene_expression denotes Expression
T9340 13332-13336 Protein denotes Sox6
T9339 13306-13308 Protein denotes ɛy
T9338 13155-13157 Protein denotes ɛy
T9337 13013-13023 Protein denotes min globin
T9336 13008-13012 Protein denotes βmaj
T9335 12905-12907 Protein denotes ɛy
T9334 12770-12779 Protein denotes ɛy globin
T9333 12681-12690 Protein denotes ɛy globin
T8038 11327-11334 Binding denotes binding
T8037 10821-10826 Binding denotes binds
T8036 10739-10749 Negative_regulation denotes repression
T8035 10718-10726 Positive_regulation denotes required
T8034 10433-10447 Positive_regulation denotes overexpression
T8033 9882-9887 Binding denotes binds
T8032 9826-9833 Gene_expression denotes express
T8031 9586-9591 Binding denotes binds
T8030 9243-9252 Binding denotes associate
T8029 8646-8656 Binding denotes associated
T8028 8554-8564 Regulation denotes regulating
T8027 8579-8588 Regulation denotes affecting
T8026 8430-8435 Binding denotes Binds
T8025 11342-11344 Protein denotes ɛy
T8024 11307-11309 Protein denotes ɛy
T8023 11275-11279 Protein denotes Sox6
T8022 11116-11120 Protein denotes Sox6
T8021 11060-11062 Protein denotes ɛy
T8020 11021-11025 Protein denotes Sox6
T8019 10913-10917 Protein denotes Sox6
T8018 10834-10836 Protein denotes ɛy
T8017 10816-10820 Protein denotes Sox6
T8016 10759-10763 Protein denotes Sox6
T8015 10753-10755 Protein denotes ɛy
T8014 10518-10520 Protein denotes ɛy
T8013 10428-10432 Protein denotes Sox6
T8012 10327-10329 Protein denotes ɛy
T8011 9868-9872 Protein denotes Sox6
T8010 9859-9861 Protein denotes ɛy
T8009 9840-9849 Protein denotes β globins
T8008 9619-9623 Protein denotes Sox6
T8007 9609-9611 Protein denotes HA
T8006 9569-9574 Protein denotes c-Myc
T8005 9517-9521 Protein denotes Sox6
T8004 9449-9453 Protein denotes Sox6
T8003 9439-9444 Protein denotes c-Myc
T8002 9410-9414 Protein denotes Sox6
T8001 9298-9300 Protein denotes ɛy
T8000 9216-9220 Protein denotes Sox6
T7999 8957-8959 Protein denotes ɛy
T7998 8764-8768 Protein denotes Sox6
T7997 8751-8756 Protein denotes c-Myc
T7996 8666-8668 Protein denotes ɛy
T7995 8629-8633 Protein denotes Sox6
T7994 8593-8595 Protein denotes ɛy
T7993 8478-8480 Protein denotes ɛy
T7992 8455-8459 Protein denotes Sox6
T7991 8443-8445 Protein denotes ɛy
T7990 8416-8420 Protein denotes Sox6
T6270 5713-5723 Negative_regulation denotes repression
T6269 5423-5430 Negative_regulation denotes repress
T6268 5544-5555 Regulation denotes independent
T6267 5507-5516 Negative_regulation denotes represses
T6266 5078-5089 Binding denotes interaction
T6265 5285-5296 Binding denotes interaction
T6264 5104-5112 Positive_regulation denotes required
T6263 5266-5273 Negative_regulation denotes abolish
T6262 5122-5132 Negative_regulation denotes repression
T6261 5006-5015 Gene_expression denotes expressed
T6260 4939-4948 Gene_expression denotes expressed
T6259 4916-4924 Binding denotes interact
T6258 3432-3439 Negative_regulation denotes repress
T6257 3238-3252 Positive_regulation denotes overexpression
T6256 3082-3096 Positive_regulation denotes Overexpression
T6255 2625-2629 Binding denotes acts
T6254 2790-2799 Gene_expression denotes expresses
T6253 5708-5712 Protein denotes Sox6
T6228 2818-2830 Protein denotes beta globins
T6227 2805-2807 Protein denotes ɛy
T6226 2637-2639 Protein denotes ɛy
T6225 2611-2615 Protein denotes Sox6
T6224 2575-2577 Protein denotes ɛy
T6223 2530-2532 Protein denotes ɛy
T6222 2421-2423 Protein denotes ɛy
T6221 2393-2397 Protein denotes Sox6
T4901 1857-1867 Gene_expression denotes expression
T4900 1731-1741 Gene_expression denotes expression
T4899 1049-1059 Gene_expression denotes expression
T4898 824-834 Gene_expression denotes expression
T4897 697-707 Gene_expression denotes expression
T4896 606-615 Gene_expression denotes expressed
T4895 236-243 Regulation denotes targets
T4894 68-77 Negative_regulation denotes Deficient
T4893 20-30 Gene_expression denotes Expression
T4892 1853-1856 Protein denotes min
T4891 1848-1852 Protein denotes βmaj
T4890 1728-1730 Protein denotes ɛy
T4889 1075-1083 Protein denotes β globin
T4888 889-892 Protein denotes βh1
T4887 883-884 Protein denotes ζ
T4886 1001-1010 Protein denotes ɛy globin
T4885 595-597 Protein denotes ɛy
T4884 322-326 Protein denotes Sox6
T4883 220-224 Protein denotes Sox6
T4882 87-96 Protein denotes ɛy globin
T4881 63-67 Protein denotes Sox6
T4880 56-58 Protein denotes ɛy
T4879 48-54 Protein denotes Globin
T6252 5666-5668 Protein denotes ɛy
T6251 5589-5591 Protein denotes ɛy
T6250 5538-5543 Protein denotes CtBP2
T6249 5521-5523 Protein denotes ɛy
T6248 5502-5506 Protein denotes Sox6
T6247 5435-5437 Protein denotes ɛy
T6246 5395-5399 Protein denotes Sox6
T6245 5279-5284 Protein denotes CtBP2
T6244 5274-5278 Protein denotes Sox6
T6243 5199-5203 Protein denotes Sox6
T6242 5140-5142 Protein denotes ɛy
T6241 5117-5121 Protein denotes Sox6
T6240 5095-5100 Protein denotes CtBP2
T6239 4997-5002 Protein denotes CtBP2
T6238 4977-4982 Protein denotes fgf-3
T6237 4963-4968 Protein denotes CtBP2
T6236 4867-4871 Protein denotes Sox6
T6235 3444-3446 Protein denotes ɛy
T6234 3419-3423 Protein denotes Sox6
T6233 3268-3272 Protein denotes Sox6
T6232 3100-3104 Protein denotes Sox6
T6231 2853-2855 Protein denotes ɛy
T6230 2997-3007 Protein denotes luciferase
T6229 2950-2952 Protein denotes ɛy
R3452 T4880 T4893 themeOf ɛy,Expression
R3453 T4881 T4894 themeOf Sox6,Deficient
R3454 T4883 T4895 themeOf Sox6,targets
R3455 T4885 T4896 themeOf ɛy,expressed
R3456 T4885 T4897 themeOf ɛy,expression
R3457 T4887 T4898 themeOf ζ,expression
R3458 T4888 T4898 themeOf βh1,expression
R3459 T4889 T4899 themeOf β globin,expression
R3460 T4890 T4900 themeOf ɛy,expression
R3461 T4891 T4901 themeOf βmaj,expression
R3462 T4892 T4901 themeOf min,expression
R4356 T6225 T6255 themeOf Sox6,acts
R4357 T6227 T6254 themeOf ɛy,expresses
R4358 T6232 T6256 themeOf Sox6,Overexpression
R4359 T6233 T6257 themeOf Sox6,overexpression
R4360 T6234 T6258 causeOf Sox6,repress
R4361 T6235 T6258 themeOf ɛy,repress
R4362 T6236 T6259 themeOf Sox6,interact
R4363 T6236 T6259 themeOf Sox6,interact
R4364 T6237 T6259 themeOf CtBP2,interact
R4365 T6237 T6260 themeOf CtBP2,expressed
R4366 T6238 T6259 themeOf fgf-3,interact
R4367 T6238 T6260 themeOf fgf-3,expressed
R4368 T6239 T6261 themeOf CtBP2,expressed
R4369 T6240 T6266 themeOf CtBP2,interaction
R4370 T6241 T6262 themeOf Sox6,repression
R4371 T6244 T6265 themeOf Sox6,interaction
R4372 T6245 T6265 themeOf CtBP2,interaction
R4373 T6247 T6269 themeOf ɛy,repress
R4374 T6248 T6267 causeOf Sox6,represses
R4375 T6249 T6267 themeOf ɛy,represses
R4376 T6250 T6268 themeOf CtBP2,independent
R4377 T6253 T6270 themeOf Sox6,repression
R4378 T6262 T6264 themeOf repression,required
R4379 T6265 T6263 themeOf interaction,abolish
R4380 T6265 T6263 themeOf interaction,abolish
R5527 T8023 T8038 themeOf Sox6,binding
R5537 T7990 T8026 themeOf Sox6,Binds
R5538 T7992 T8028 causeOf Sox6,regulating
R5539 T8024 T8038 themeOf ɛy,binding
R5540 T8025 T8038 themeOf ɛy,binding
R5541 T7994 T8027 themeOf ɛy,affecting
R5542 T8025 T8038 themeOf ɛy,binding
R5543 T8027 T8028 themeOf affecting,regulating
R5544 T7995 T8029 themeOf Sox6,associated
R5545 T8036 T8035 themeOf repression,required
R5546 T8001 T8030 themeOf ɛy,associate
R5548 T8006 T8031 themeOf c-Myc,binds
R5551 T8010 T8032 themeOf ɛy,express
R5552 T8011 T8033 themeOf Sox6,binds
R5554 T8013 T8034 themeOf Sox6,overexpression
R5556 T8015 T8036 themeOf ɛy,repression
R5558 T8016 T8036 causeOf Sox6,repression
R5560 T8016 T8035 causeOf Sox6,required
R5562 T8017 T8037 themeOf Sox6,binds
R5564 T8018 T8037 themeOf ɛy,binds
R6472 T9327 T9341 themeOf ɛy Globin,Expression
R6473 T9328 T9342 themeOf Sox6,Deficient
R6474 T9330 T9343 themeOf ɛy globin,expressed
R6475 T9331 T9346 themeOf ɛy globin,expression
R6476 T9332 T9345 themeOf ɛy globin,expression
R6477 T9334 T9347 themeOf ɛy globin,expressed
R6478 T9335 T9348 themeOf ɛy,expression
R6479 T9336 T9349 themeOf βmaj,expression
R6480 T9337 T9349 themeOf min globin,expression
R6481 T9338 T9352 themeOf ɛy,expression
R6482 T9339 T9351 themeOf ɛy,defect
R6483 T9340 T9350 themeOf Sox6,null
R6484 T9345 T9344 themeOf expression,due
R6485 T9346 T9344 themeOf expression,due
R6951 T10038 T10048 themeOf Sox6,Expression
R6952 T10039 T10050 themeOf Sox6,deficient
R6953 T10040 T10049 themeOf ɛy globin,express
R6954 T10042 T10051 themeOf Sox6,expression
R6955 T10045 T10052 themeOf Sox6,expression
R6956 T10047 T10053 themeOf ɛy globin,expressed
R7292 T10501 T10504 themeOf Sox6,effects
R7293 T10502 T10505 themeOf ɛy globin,silencing

DLUT931

Id Subject Object Predicate Lexical cue
T10079 14879-14888 Gene_expression denotes expressed
T10078 14704-14714 Gene_expression denotes expression
T10077 14288-14298 Gene_expression denotes expression
T10076 14106-14113 Gene_expression denotes express
T10075 14079-14088 Negative_regulation denotes deficient
T10074 13981-13991 Gene_expression denotes Expression
T10073 14859-14868 Protein denotes ɛy globin
T10072 14967-14971 Protein denotes Sox6
T10071 14699-14703 Protein denotes Sox6
T10070 14584-14588 Protein denotes Sox6
T10069 14401-14405 Protein denotes Sox6
T10068 14310-14314 Protein denotes Sox6
T10067 14189-14193 Protein denotes Sox6
T10066 14114-14123 Protein denotes ɛy globin
T10065 14074-14078 Protein denotes Sox6
T10064 14003-14007 Protein denotes Sox6
T10518 16710-16719 Negative_regulation denotes silencing
T10517 16142-16149 Regulation denotes effects
T10516 16740-16744 Protein denotes Sox6
T10515 16724-16733 Protein denotes ɛy globin
T10514 16137-16141 Protein denotes Sox6
T9401 13162-13165 Positive_regulation denotes due
T9400 13337-13341 Negative_regulation denotes null
T9399 13309-13318 Negative_regulation denotes silencing
T9398 13292-13298 Negative_regulation denotes defect
T9397 13177-13187 Gene_expression denotes expression
T9396 13035-13043 Positive_regulation denotes abundant
T9395 12994-13004 Gene_expression denotes expression
T9394 12897-12904 Positive_regulation denotes ectopic
T9393 12913-12923 Transcription denotes expression
T9392 12787-12796 Gene_expression denotes expressed
T9391 12691-12702 Transcription denotes transcripts
T9390 12594-12604 Gene_expression denotes expression
T9389 12579-12582 Positive_regulation denotes due
T9388 12534-12537 Positive_regulation denotes due
T9387 12507-12517 Gene_expression denotes expression
T9386 12434-12442 Negative_regulation denotes silenced
T9385 12394-12403 Gene_expression denotes expressed
T9384 12295-12309 Gene_expression denotes Gene–Silencing
T9383 12269-12272 Positive_regulation denotes Due
T9382 12251-12260 Negative_regulation denotes Deficient
T9381 12219-12229 Gene_expression denotes Expression
T9380 13332-13336 Protein denotes Sox6
T9379 13306-13308 Protein denotes ɛy
T9378 13155-13157 Protein denotes ɛy
T9377 13013-13023 Protein denotes min globin
T9376 13008-13012 Protein denotes βmaj
T9375 12905-12907 Protein denotes ɛy
T9374 12770-12779 Protein denotes ɛy globin
T9373 12681-12690 Protein denotes ɛy globin
T9372 12608-12617 Protein denotes ɛy globin
T9371 12521-12530 Protein denotes ɛy globin
T9370 12364-12373 Protein denotes ɛy globin
T9369 12292-12294 Protein denotes ɛy
T9368 12246-12250 Protein denotes Sox6
T9367 12233-12242 Protein denotes ɛy Globin
T8092 11327-11334 Binding denotes binding
T8091 11290-11299 Negative_regulation denotes repressor
T8090 10821-10826 Binding denotes binds
T8089 10718-10726 Positive_regulation denotes required
T8088 10739-10749 Negative_regulation denotes repression
T8087 10433-10447 Gene_expression denotes overexpression
T8086 10404-10418 Gene_expression denotes co-transfected
T8085 9882-9887 Binding denotes binds
T8084 9826-9833 Gene_expression denotes express
T8083 9612-9618 Binding denotes tagged
T8082 9586-9591 Binding denotes binds
T8081 9506-9513 Binding denotes binding
T8080 9243-9252 Binding denotes associate
T8079 8646-8656 Binding denotes associated
T8078 8554-8564 Regulation denotes regulating
T8077 8579-8588 Regulation denotes affecting
T8076 8522-8529 Binding denotes contact
T8075 8430-8435 Binding denotes Binds
T8074 11342-11344 Protein denotes ɛy
T8073 11307-11309 Protein denotes ɛy
T8072 11275-11279 Protein denotes Sox6
T8071 11116-11120 Protein denotes Sox6
T8070 11060-11062 Protein denotes ɛy
T8069 11021-11025 Protein denotes Sox6
T8068 10913-10917 Protein denotes Sox6
T8067 10834-10836 Protein denotes ɛy
T8066 10816-10820 Protein denotes Sox6
T8065 10759-10763 Protein denotes Sox6
T8064 10753-10755 Protein denotes ɛy
T8063 10518-10520 Protein denotes ɛy
T8062 10428-10432 Protein denotes Sox6
T8061 10327-10329 Protein denotes ɛy
T8060 9868-9872 Protein denotes Sox6
T8059 9859-9861 Protein denotes ɛy
T8058 9840-9849 Protein denotes β globins
T8057 9619-9623 Protein denotes Sox6
T8056 9609-9611 Protein denotes HA
T8055 9569-9574 Protein denotes c-Myc
T8054 9517-9521 Protein denotes Sox6
T8053 9449-9453 Protein denotes Sox6
T8052 9439-9444 Protein denotes c-Myc
T8051 9410-9414 Protein denotes Sox6
T8050 9298-9300 Protein denotes ɛy
T8049 9216-9220 Protein denotes Sox6
T8048 8957-8959 Protein denotes ɛy
T8047 8764-8768 Protein denotes Sox6
T8046 8751-8756 Protein denotes c-Myc
T8045 8666-8668 Protein denotes ɛy
T8044 8629-8633 Protein denotes Sox6
T8043 8593-8595 Protein denotes ɛy
T8042 8478-8480 Protein denotes ɛy
T8041 8455-8459 Protein denotes Sox6
T8040 8443-8445 Protein denotes ɛy
T8039 8416-8420 Protein denotes Sox6
T6322 5713-5723 Negative_regulation denotes repression
T6321 5544-5555 Regulation denotes independent
T6320 5507-5516 Negative_regulation denotes represses
T6319 5423-5430 Negative_regulation denotes repress
T6318 5266-5273 Negative_regulation denotes abolish
T6317 5104-5112 Positive_regulation denotes required
T6316 5285-5296 Binding denotes interaction
T6315 5175-5183 Regulation denotes mutation
T6314 5122-5132 Negative_regulation denotes repression
T6313 5078-5089 Binding denotes interaction
T6312 5006-5015 Gene_expression denotes expressed
T6311 4939-4948 Gene_expression denotes expressed
T6310 4916-4924 Binding denotes interact
T6309 3432-3439 Negative_regulation denotes repress
T6308 3238-3252 Positive_regulation denotes overexpression
T6307 3082-3096 Positive_regulation denotes Overexpression
T6306 2790-2799 Gene_expression denotes expresses
T6305 2625-2629 Positive_regulation denotes acts
T6304 2407-2416 Negative_regulation denotes Represses
T6303 5708-5712 Protein denotes Sox6
T6302 5666-5668 Protein denotes ɛy
T6301 5589-5591 Protein denotes ɛy
T6300 5538-5543 Protein denotes CtBP2
T6299 5521-5523 Protein denotes ɛy
T6298 5502-5506 Protein denotes Sox6
T6297 5435-5437 Protein denotes ɛy
T6296 5395-5399 Protein denotes Sox6
T6295 5279-5284 Protein denotes CtBP2
T6294 5274-5278 Protein denotes Sox6
T6293 5199-5203 Protein denotes Sox6
T6292 5140-5142 Protein denotes ɛy
T6291 5117-5121 Protein denotes Sox6
T6290 5095-5100 Protein denotes CtBP2
T6289 4997-5002 Protein denotes CtBP2
T6288 4977-4982 Protein denotes fgf-3
T6287 4963-4968 Protein denotes CtBP2
T6286 4867-4871 Protein denotes Sox6
T6285 3444-3446 Protein denotes ɛy
T6284 3419-3423 Protein denotes Sox6
T6283 3268-3272 Protein denotes Sox6
T6282 3100-3104 Protein denotes Sox6
T6281 2853-2855 Protein denotes ɛy
T6280 2997-3007 Protein denotes luciferase
T6279 2950-2952 Protein denotes ɛy
T6278 2818-2830 Protein denotes beta globins
T6277 2805-2807 Protein denotes ɛy
T6276 2637-2639 Protein denotes ɛy
T6275 2611-2615 Protein denotes Sox6
T6274 2575-2577 Protein denotes ɛy
T6273 2530-2532 Protein denotes ɛy
T6272 2421-2423 Protein denotes ɛy
T6271 2393-2397 Protein denotes Sox6
T4943 1821-1831 Positive_regulation denotes equivalent
T4942 1719-1724 Negative_regulation denotes level
T4941 1857-1867 Gene_expression denotes expression
T4940 1731-1741 Gene_expression denotes expression
T4939 1101-1107 Positive_regulation denotes higher
T4938 1049-1059 Gene_expression denotes expression
T4937 903-909 Positive_regulation denotes higher
T4936 824-834 Gene_expression denotes expression
T4935 697-707 Gene_expression denotes expression
T4934 606-615 Gene_expression denotes expressed
T4933 236-243 Regulation denotes targets
T4932 9-19 Negative_regulation denotes Persistent
T4931 68-77 Negative_regulation denotes Deficient
T4930 20-30 Gene_expression denotes Expression
T4929 1853-1856 Protein denotes min
T4928 1848-1852 Protein denotes βmaj
T4927 1728-1730 Protein denotes ɛy
T4926 1075-1083 Protein denotes β globin
T4925 889-892 Protein denotes βh1
T4924 883-884 Protein denotes ζ
T4923 1001-1010 Protein denotes ɛy globin
T4922 595-597 Protein denotes ɛy
T4921 322-326 Protein denotes Sox6
T4920 220-224 Protein denotes Sox6
T4919 87-96 Protein denotes ɛy globin
T4918 63-67 Protein denotes Sox6
T4917 56-58 Protein denotes ɛy
T4916 48-54 Protein denotes Globin
R3463 T4916 T4930 themeOf Globin,Expression
R3464 T4917 T4930 themeOf ɛy,Expression
R3465 T4918 T4931 themeOf Sox6,Deficient
R3466 T4920 T4933 themeOf Sox6,targets
R3467 T4922 T4934 themeOf ɛy,expressed
R3468 T4922 T4935 themeOf ɛy,expression
R3469 T4924 T4936 themeOf ζ,expression
R3470 T4924 T4937 themeOf ζ,higher
R3471 T4925 T4936 themeOf βh1,expression
R3472 T4925 T4937 themeOf βh1,higher
R3473 T4926 T4938 themeOf β globin,expression
R3474 T4927 T4940 themeOf ɛy,expression
R3475 T4928 T4941 themeOf βmaj,expression
R3476 T4929 T4941 themeOf min,expression
R3477 T4930 T4932 themeOf Expression,Persistent
R3478 T4930 T4932 themeOf Expression,Persistent
R3479 T4936 T4937 themeOf expression,higher
R3480 T4936 T4937 themeOf expression,higher
R3481 T4938 T4939 themeOf expression,higher
R3482 T4940 T4942 themeOf expression,level
R3483 T4941 T4943 themeOf expression,equivalent
R3484 T4941 T4943 themeOf expression,equivalent
R4381 T6271 T6304 causeOf Sox6,Represses
R4382 T6272 T6304 themeOf ɛy,Represses
R4383 T6275 T6305 causeOf Sox6,acts
R4384 T6276 T6305 themeOf ɛy,acts
R4385 T6277 T6306 themeOf ɛy,expresses
R4386 T6278 T6306 themeOf beta globins,expresses
R4387 T6282 T6307 themeOf Sox6,Overexpression
R4388 T6283 T6308 themeOf Sox6,overexpression
R4389 T6284 T6309 causeOf Sox6,repress
R4390 T6285 T6309 themeOf ɛy,repress
R4391 T6286 T6310 themeOf Sox6,interact
R4392 T6286 T6310 themeOf Sox6,interact
R4393 T6287 T6310 themeOf CtBP2,interact
R4394 T6287 T6310 themeOf CtBP2,interact
R4395 T6288 T6311 themeOf fgf-3,expressed
R4396 T6288 T6310 themeOf fgf-3,interact
R4397 T6288 T6310 themeOf fgf-3,interact
R4398 T6289 T6312 themeOf CtBP2,expressed
R4399 T6290 T6313 themeOf CtBP2,interaction
R4400 T6291 T6314 themeOf Sox6,repression
R4401 T6292 T6314 themeOf ɛy,repression
R4402 T6293 T6315 themeOf Sox6,mutation
R4403 T6294 T6316 themeOf Sox6,interaction
R4404 T6295 T6316 themeOf CtBP2,interaction
R4405 T6297 T6319 themeOf ɛy,repress
R4406 T6298 T6320 causeOf Sox6,represses
R4407 T6299 T6320 themeOf ɛy,represses
R4408 T6300 T6321 causeOf CtBP2,independent
R4409 T6303 T6322 themeOf Sox6,repression
R4410 T6313 T6317 causeOf interaction,required
R4411 T6313 T6317 causeOf interaction,required
R4412 T6314 T6317 themeOf repression,required
R4413 T6314 T6317 themeOf repression,required
R4414 T6316 T6318 themeOf interaction,abolish
R4415 T6320 T6321 themeOf represses,independent
R5547 T8039 T8075 themeOf Sox6,Binds
R5549 T8040 T8075 themeOf ɛy,Binds
R5550 T8042 T8076 themeOf ɛy,contact
R5553 T8043 T8077 themeOf ɛy,affecting
R5555 T8044 T8079 themeOf Sox6,associated
R5557 T8045 T8079 themeOf ɛy,associated
R5559 T8049 T8080 themeOf Sox6,associate
R5561 T8050 T8080 themeOf ɛy,associate
R5563 T8054 T8081 themeOf Sox6,binding
R5565 T8055 T8082 themeOf c-Myc,binds
R5566 T8056 T8083 themeOf HA,tagged
R5567 T8057 T8083 themeOf Sox6,tagged
R5568 T8058 T8084 themeOf β globins,express
R5569 T8059 T8084 themeOf ɛy,express
R5570 T8060 T8085 themeOf Sox6,binds
R5571 T8061 T8086 themeOf ɛy,co-transfected
R5574 T8062 T8087 themeOf Sox6,overexpression
R5575 T8062 T8086 themeOf Sox6,co-transfected
R5576 T8064 T8088 themeOf ɛy,repression
R5578 T8065 T8088 themeOf Sox6,repression
R5580 T8066 T8090 themeOf Sox6,binds
R5582 T8067 T8090 themeOf ɛy,binds
R5583 T8072 T8091 causeOf Sox6,repressor
R5584 T8072 T8092 themeOf Sox6,binding
R5585 T8073 T8091 themeOf ɛy,repressor
R5587 T8073 T8091 themeOf ɛy,repressor
R5588 T8074 T8092 themeOf ɛy,binding
R5590 T8077 T8078 themeOf affecting,regulating
R5593 T8088 T8089 themeOf repression,required
R5599 T8088 T8089 themeOf repression,required
R5601 T8092 T8091 causeOf binding,repressor
R6486 T9367 T9381 themeOf ɛy Globin,Expression
R6487 T9368 T9382 themeOf Sox6,Deficient
R6488 T9369 T9384 themeOf ɛy,Gene–Silencing
R6489 T9370 T9385 themeOf ɛy globin,expressed
R6490 T9370 T9386 themeOf ɛy globin,silenced
R6491 T9371 T9387 themeOf ɛy globin,expression
R6492 T9372 T9390 themeOf ɛy globin,expression
R6493 T9373 T9391 themeOf ɛy globin,transcripts
R6494 T9374 T9392 themeOf ɛy globin,expressed
R6495 T9375 T9393 themeOf ɛy,expression
R6496 T9376 T9395 themeOf βmaj,expression
R6497 T9377 T9395 themeOf min globin,expression
R6498 T9378 T9397 themeOf ɛy,expression
R6499 T9379 T9398 themeOf ɛy,defect
R6500 T9379 T9399 themeOf ɛy,silencing
R6501 T9380 T9400 themeOf Sox6,null
R6502 T9381 T9383 themeOf Expression,Due
R6503 T9387 T9388 themeOf expression,due
R6504 T9387 T9389 themeOf expression,due
R6505 T9390 T9389 themeOf expression,due
R6506 T9393 T9394 themeOf expression,ectopic
R6507 T9395 T9396 themeOf expression,abundant
R6508 T9395 T9396 themeOf expression,abundant
R6509 T9397 T9401 themeOf expression,due
R6510 T9399 T9398 themeOf silencing,defect
R6957 T10064 T10074 themeOf Sox6,Expression
R6958 T10065 T10075 themeOf Sox6,deficient
R6959 T10066 T10076 themeOf ɛy globin,express
R6960 T10068 T10077 themeOf Sox6,expression
R6961 T10071 T10078 themeOf Sox6,expression
R6962 T10073 T10079 themeOf ɛy globin,expressed
R7295 T10514 T10517 themeOf Sox6,effects
R7296 T10515 T10518 themeOf ɛy globin,silencing
R7297 T10516 T10518 causeOf Sox6,silencing

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Negation
T10677 16710-16739 Negative_regulation denotes silencing the ɛy globin gene,
T10676 16532-16564 Entity denotes in hematopoietic precursor cells
T10675 16575-16597 Entity denotes nucleated erythrocytes
T10674 16720-16738 Protein denotes the ɛy globin gene
T10673 16660-16668 Entity denotes 14.5 dpc
T10672 16296-16304 Entity denotes 18.5 dpc
T10671 16283-16291 Entity denotes 14.5 dpc
T10670 16246-16263 Protein denotes p100H mutant mice
T10669 16376-16395 Entity denotes nucleated red cells
T10668 16098-16120 Entity denotes of Nucleated Red Cells
T10667 16127-16168 Protein denotes the other Sox6 effects in erythropoiesis,
T10666 16740-16744 Protein denotes Sox6
T10665 16272-16316 Protein denotes WT mice at 14.5 dpc and 18.5 dpc (Figure 7A)
T10664 16606-16621 Entity denotes dpc (Figure 7B)
T10663 16412-16424 Protein denotes mutant mice,
T10662 16060-16077 Protein denotes Mutant p100H Mice
T10661 16098-16120 Protein denotes of Nucleated Red Cells
T10660 16724-16733 Protein denotes ɛy globin
T10304 14699-14714 Gene_expression denotes Sox6 expression
T10303 14551-14686 Transcription denotes in situ hybridization shows that Sox6 is highly transcribed in 12.5-dpc liver, but not in yolk sac blood islands at 7.5 dpc (Figure 6B)
T10302 14699-14703 Protein denotes Sox6
T10301 14114-14123 Protein denotes ɛy globin
T10300 14003-14007 Protein denotes Sox6
T10299 14911-14948 Protein denotes 14.5-dpc p100H mutant mice (Figure 5)
T10298 14401-14405 Protein denotes Sox6
T10297 14140-14166 Entity denotes definitive erythroid cells
T10296 14646-14649 Protein denotes sac
T10295 14854-14868 Protein denotes that ɛy globin
T10294 14967-14971 Protein denotes Sox6
T10293 14667-14686 Entity denotes 7.5 dpc (Figure 6B)
T10292 14584-14588 Protein denotes Sox6
T10291 14017-14023 Entity denotes a Role
T10290 14641-14645 Entity denotes yolk
T10289 14455-14536 Entity denotes dpc, coincident with the temporal onset of definitive erythropoiesis in the liver
T10288 14310-14314 Protein denotes Sox6
T10287 14074-14093 Protein denotes Sox6-deficient mice
T10286 14189-14193 Protein denotes Sox6
T10285 14892-14948 Entity denotes the liver cells of 14.5-dpc p100H mutant mice (Figure 5)
T9685 12360-12469 Gene_expression denotes the ɛy globin gene is exclusively expressed in primitive erythrocytes and silenced in definitive erythrocytes
T9684 12770-12822 Gene_expression denotes ɛy globin is not expressed in the WT 14.5-dpc liver, true
T9683 12605-12644 Localization denotes of ɛy globin in definitive erythrocytes
T9682 12360-12469 Negative_regulation denotes the ɛy globin gene is exclusively expressed in primitive erythrocytes and silenced in definitive erythrocytes
T9681 12204-12260 Gene_expression denotes The Persistent Expression of ɛy Globin in Sox6-Deficient
T9680 12586-12644 Gene_expression denotes ectopic expression of ɛy globin in definitive erythrocytes
T9679 12492-12530 Gene_expression denotes the persistent expression of ɛy globin
T9678 12875-12964 Transcription denotes In contrast, abundant ectopic ɛy mRNA expression is seen in the liver of 14.5-dpc mutants
T9677 12875-12964 Gene_expression denotes In contrast, abundant ectopic ɛy mRNA expression is seen in the liver of 14.5-dpc mutants
T9676 12990-13023 Gene_expression denotes the expression of βmaj/min globin
T9675 12323-12349 Entity denotes Definitive Erythroid Cells
T9674 12360-12378 Protein denotes the ɛy globin gene
T9673 12230-12242 Protein denotes of ɛy Globin
T9672 12605-12644 Protein denotes of ɛy globin in definitive erythrocytes
T9671 13155-13157 Protein denotes ɛy
T9670 12541-12572 Entity denotes residual primitive erythrocytes
T9669 12367-12373 Protein denotes globin
T9668 13332-13346 Protein denotes Sox6-null mice
T9667 12360-12378 Protein denotes the ɛy globin gene
T9666 13059-13076 Protein denotes p100H mutant mice
T9665 12684-12690 Entity denotes globin
T9664 12908-12912 Protein denotes mRNA
T9663 13093-13094 Entity denotes F
T9662 12261-12265 Protein denotes Mice
T9661 12966-12978 Entity denotes Figure 5 A–D
T9660 12681-12702 Protein denotes ɛy globin transcripts
T9659 13191-13252 Entity denotes the definitive erythroid cells that mature in the fetal liver
T9658 12770-12779 Protein denotes ɛy globin
T9657 12446-12469 Entity denotes definitive erythrocytes
T9656 12621-12644 Entity denotes definitive erythrocytes
T9655 13008-13012 Protein denotes βmaj
T9654 13005-13023 Protein denotes of βmaj/min globin
T9653 12681-12702 Protein denotes ɛy globin transcripts
T9652 12246-12260 Protein denotes Sox6-Deficient
T9651 13306-13308 Protein denotes ɛy
T9650 12518-12530 Protein denotes of ɛy globin
T9649 12888-12923 Protein denotes abundant ectopic ɛy mRNA expression
T9648 12407-12429 Entity denotes primitive erythrocytes
T8858 10085-10136 Binding denotes putative Sox/Sox6 binding sites (M1 and M3) abolish
T8857 10793-10896 Binding denotes We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP)
T8856 11318-11344 Binding denotes directly binding to the ɛy
T8855 9935-9995 Binding denotes The intact consensus Sox/Sox6 binding sites of the DNA probe
T8854 10385-10398 Binding denotes binding sites
T8853 9868-9933 Binding denotes Sox6 directly binds to this DNA sequence in MEL cells (Figure 3D)
T8852 9396-9422 Binding denotes by the tagged Sox6 protein
T8851 9032-9068 Binding denotes two consensus Sox/Sox6 binding sites
T8850 8629-8677 Binding denotes Sox6 is directly associated with the ɛy promoter
T8849 8385-8454 Binding denotes EMSA and ChIP Assays Show that Sox6 Directly Binds to the ɛy Promoter
T8848 10225-10240 Binding denotes with WT binding
T8847 9050-9054 Protein denotes Sox6
T8846 8749-8841 Protein denotes a c-Myc-tagged Sox6 in a reticulocyte lysate-based transcription/translation in vitro system
T8845 10570-10597 Entity denotes both Sox/Sox6 binding sites
T8844 8666-8668 Protein denotes ɛy
T8843 10380-10384 Protein denotes Sox6
T8842 10860-10869 Entity denotes chromatin
T8841 8984-8992 Entity denotes promoter
T8840 9973-9978 Entity denotes sites
T8839 11335-11344 Protein denotes to the ɛy
T8838 10118-10120 Entity denotes M1
T8837 9216-9220 Protein denotes Sox6
T8836 10625-10695 Entity denotes in significant promoter repression in transfection studies (Figure 3F)
T8835 9166-9168 Entity denotes M2
T8834 8629-8633 Protein denotes Sox6
T8833 10759-10764 Protein denotes Sox6,
T8832 10094-10102 Protein denotes Sox/Sox6
T8831 10428-10432 Protein denotes Sox6
T8830 10998-11034 Protein denotes 15.5 dpc WT mice using Sox6 antibody
T8829 8416-8420 Protein denotes Sox6
T8828 10834-10836 Protein denotes ɛy
T8827 10098-10102 Protein denotes Sox6
T8826 8535-8547 Entity denotes the promoter
T8825 8957-8959 Protein denotes ɛy
T8824 9859-9866 Protein denotes ɛy [33]
T8823 10111-10128 Entity denotes sites (M1 and M3)
T8822 9439-9444 Protein denotes c-Myc
T8821 9184-9188 Protein denotes Sox6
T8820 10038-10071 Entity denotes the competition assay (Figure 3E)
T8819 10299-10307 Protein denotes Sox/Sox6
T8818 10909-10917 Protein denotes The Sox6
T8817 10385-10398 Entity denotes binding sites
T8816 9896-9899 Entity denotes DNA
T8815 9517-9530 Protein denotes Sox6-specific
T8814 9569-9574 Protein denotes c-Myc
T8813 10376-10384 Protein denotes Sox/Sox6
T8812 9434-9470 Entity denotes both c-Myc and Sox6 antibodies super
T8811 11367-11374 Entity denotes a dimer
T8810 10703-10713 Entity denotes both sites
T8809 10575-10583 Protein denotes Sox/Sox6
T8808 9173-9175 Entity denotes M3
T8807 11275-11279 Protein denotes Sox6
T8806 11133-11163 Entity denotes both MEL cells and liver cells
T8805 9032-9068 Entity denotes two consensus Sox/Sox6 binding sites
T8804 9149-9151 Entity denotes M1
T8803 11303-11314 Protein denotes the ɛy gene
T8802 9449-9453 Protein denotes Sox6
T8801 10816-10820 Protein denotes Sox6
T8800 8657-8677 Entity denotes with the ɛy promoter
T8799 10827-10896 Entity denotes to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP)
T8798 8950-8968 Entity denotes of the ɛy promoter
T8797 9046-9054 Protein denotes Sox/Sox6
T8796 9982-9995 Entity denotes the DNA probe
T8795 9935-9995 Protein denotes The intact consensus Sox/Sox6 binding sites of the DNA probe
T8794 11303-11314 Protein denotes the ɛy gene
T8793 11021-11025 Protein denotes Sox6
T8792 8774-8786 Entity denotes reticulocyte
T8791 10460-10471 Entity denotes GM979 cells
T8790 10323-10384 Entity denotes the ɛy promoter reporter constructs with mutagenized Sox/Sox6
T8789 11056-11062 Protein denotes the ɛy
T8788 10376-10384 Protein denotes Sox/Sox6
T8787 9046-9054 Protein denotes Sox/Sox6
T8786 9609-9623 Protein denotes HA-tagged Sox6
T8785 10507-10549 Entity denotes the mutant ɛy promoter reporter constructs
T8784 8436-8454 Entity denotes to the ɛy Promoter
T8783 11345-11353 Entity denotes promoter
T8782 8478-8480 Protein denotes ɛy
T8781 8565-8604 Entity denotes intermediates affecting the ɛy promoter
T8780 10303-10307 Protein denotes Sox6
T8779 10575-10583 Protein denotes Sox/Sox6
T8778 8593-8595 Protein denotes ɛy
T8777 9834-9866 Protein denotes adult β globins, but not ɛy [33]
T8776 8443-8445 Protein denotes ɛy
T8775 11111-11129 Entity denotes with Sox6 antibody
T8774 9868-9872 Protein denotes Sox6
T8773 10750-10755 Protein denotes of ɛy
T8772 10187-10189 Entity denotes M2
T8771 10518-10520 Protein denotes ɛy
T8770 9294-9366 Entity denotes the ɛy promoter defined by the deletion analysis experiments (Figure 2C)
T8769 9396-9422 Protein denotes by the tagged Sox6 protein
T8768 10327-10329 Protein denotes ɛy
T8767 11072-11080 Entity denotes promoter
T8766 11003-11006 Entity denotes dpc
T8765 11116-11120 Protein denotes Sox6
T8764 9298-9300 Protein denotes ɛy
T8763 9180-9188 Protein denotes Sox/Sox6
T8762 8589-8604 Entity denotes the ɛy promoter
T8761 10299-10307 Protein denotes Sox/Sox6
T8760 8455-8459 Protein denotes Sox6
T8759 9180-9188 Protein denotes Sox/Sox6
T8758 11021-11034 Protein denotes Sox6 antibody
T8757 10094-10102 Protein denotes Sox/Sox6
T8756 10579-10583 Protein denotes Sox6
T8755 8474-8490 Entity denotes the ɛy promoter,
T8754 9410-9414 Protein denotes Sox6
T6881 5274-5300 Binding denotes Sox6-CtBP2 interaction [5]
T6880 5074-5100 Binding denotes the interaction with CtBP2
T6879 3082-3145 Gene_expression denotes Overexpression of Sox6 in GM979 cells by transient transfection
T6878 3082-3145 Positive_regulation denotes Overexpression of Sox6 in GM979 cells by transient transfection
T6877 4997-5049 Gene_expression denotes CtBP2 is expressed in GM979 cells (unpublished data)
T6876 5589-5591 Protein denotes ɛy
T6875 5582-5600 Entity denotes of the ɛy promoter
T6874 2568-2586 Entity denotes of the ɛy promoter
T6873 5133-5151 Entity denotes of the ɛy promoter
T6872 3292-3311 Entity denotes its HMG domain [32]
T6871 5708-5712 Protein denotes Sox6
T6870 5502-5506 Protein denotes Sox6
T6869 2812-2835 Protein denotes adult beta globins [30]
T6868 2421-2423 Protein denotes ɛy
T6867 2633-2653 Entity denotes the ɛy gene promoter
T6866 2367-2378 Entity denotes GM979 Cells
T6865 2990-3022 Protein denotes by the luciferase reporter gene,
T6864 5140-5142 Protein denotes ɛy
T6863 4867-4871 Protein denotes Sox6
T6862 5199-5203 Protein denotes Sox6
T6861 2850-2873 Entity denotes an ɛy promoter reporter
T6860 5538-5555 Protein denotes CtBP2-independent
T6859 2915-2919 Protein denotes μLCR
T6858 3228-3280 Protein denotes contrast, overexpression of a truncated Sox6 protein
T6857 2530-2538 Protein denotes ɛy mRNA,
T6856 3444-3446 Protein denotes ɛy
T6855 5395-5399 Protein denotes Sox6
T6854 2737-2749 Entity denotes GM979 cells,
T6853 5195-5251 Protein denotes the Sox6 protein that has been previously reported to be
T6852 2946-2979 Entity denotes the ɛy proximal promoter (2.2 kb)
T6851 3440-3455 Entity denotes the ɛy promoter
T6850 4973-4995 Entity denotes the fgf-3 promoter [5]
T6849 2950-2952 Protein denotes ɛy
T6848 5302-5317 Entity denotes This amino acid
T6847 2853-2855 Protein denotes ɛy
T6846 5517-5532 Entity denotes the ɛy promoter
T6845 3321-3347 Protein denotes to the p 100H mouse allele
T6844 2477-2480 Protein denotes PCR
T6843 3419-3423 Protein denotes Sox6
T6842 5274-5300 Protein denotes Sox6-CtBP2 interaction [5]
T6841 5335-5361 Entity denotes the HMG DNA binding domain
T6840 4963-4968 Protein denotes CtBP2
T6839 3097-3104 Protein denotes of Sox6
T6838 5662-5686 Entity denotes the ɛy proximal promoter
T6837 5450-5484 Entity denotes the transfection assay (Figure 2B)
T6836 5431-5485 Entity denotes the ɛy promoter in the transfection assay (Figure 2B),
T6835 5279-5284 Protein denotes CtBP2
T6834 2388-2397 Protein denotes That Sox6
T6833 5521-5523 Protein denotes ɛy
T6832 5435-5437 Protein denotes ɛy
T6831 5019-5049 Entity denotes GM979 cells (unpublished data)
T6830 2633-2653 Protein denotes the ɛy gene promoter
T6829 4973-4995 Protein denotes the fgf-3 promoter [5]
T6828 2997-3007 Protein denotes luciferase
T6827 2575-2577 Protein denotes ɛy
T6826 5794-5803 Entity denotes sites [5]
T6825 5117-5121 Protein denotes Sox6
T6824 2611-2615 Protein denotes Sox6
T6823 2530-2532 Protein denotes ɛy
T6822 4997-5002 Protein denotes CtBP2
T6821 5666-5668 Protein denotes ɛy
T6820 2417-2466 Entity denotes the ɛy Gene Promoter at the Transcriptional Level
T6819 5763-5785 Protein denotes two Sox/Sox6 consensus
T6818 2805-2807 Protein denotes ɛy
T6817 3268-3272 Protein denotes Sox6
T6816 2637-2639 Protein denotes ɛy
T6815 2417-2466 Protein denotes the ɛy Gene Promoter at the Transcriptional Level
T6814 3108-3145 Entity denotes GM979 cells by transient transfection
T6813 5090-5100 Protein denotes with CtBP2
T5345 720-727 Protein denotes WT mice
T5400 130-243 Positive_regulation denotes an upregulated transcript in the p 100H mouse using subtractive hybridization to identify Sox6 downstream targets
T5399 1728-1803 Gene_expression denotes ɛy expression in the livers of 15.5 dpc and 18.5 dpc homozygous mutant mice
T5398 682-727 Regulation denotes the decline in expression observed in WT mice
T5397 1258-1304 Gene_expression denotes us from evaluating postnatal globin expression
T5396 578-630 Gene_expression denotes in Figure 1, the ɛy gene is expressed at high levels
T5395 9-82 Gene_expression denotes Persistent Expression of the Embryonic Globin, ɛy, in Sox6-Deficient Mice
T5394 83-101 Protein denotes The ɛy globin gene
T5393 1350-1353 Protein denotes PCR
T5392 1885-1893 Entity denotes 15.5 dpc
T5391 1848-1856 Protein denotes βmaj/min
T5390 945-957 Protein denotes with WT mice
T5389 559-567 Entity denotes 18.5 dpc
T5388 1682-1700 Protein denotes WT fetal mice [29]
T5387 1287-1293 Protein denotes globin
T5386 322-326 Protein denotes Sox6
T5385 1728-1730 Protein denotes ɛy
T5384 1069-1083 Protein denotes adult β globin
T5383 546-554 Entity denotes 15.5 dpc
T5382 1759-1767 Entity denotes 15.5 dpc
T5381 400-413 Protein denotes Real-time PCR
T5380 1193-1207 Protein denotes of mutant mice
T5379 889-892 Protein denotes βh1
T5378 38-47 Protein denotes Embryonic
T5377 1014-1033 Entity denotes 18.5 dpc (Figure 1)
T5376 913-958 Protein denotes p100H homozygous mice, compared with WT mice,
T5375 56-58 Protein denotes ɛy
T5374 1848-1856 Protein denotes βmaj/min
T5373 1152-1171 Entity denotes 18.5 dpc (Figure 1)
T5372 1141-1171 Protein denotes WT mice at 18.5 dpc (Figure 1)
T5371 591-602 Protein denotes the ɛy gene
T5370 1777-1780 Entity denotes dpc
T5369 468-474 Protein denotes globin
T5368 90-96 Protein denotes globin
T5367 595-597 Protein denotes ɛy
T5366 767-803 Protein denotes heterozygous mice (unpublished data)
T5365 1772-1803 Protein denotes 18.5 dpc homozygous mutant mice
T5364 1898-1925 Protein denotes 18.5 dpc homozygous WT mice
T5363 287-331 Protein denotes an independent knock-out allele of Sox6 [13]
T5362 1853-1856 Protein denotes min
T5361 1903-1906 Entity denotes dpc
T5360 31-59 Protein denotes of the Embryonic Globin, ɛy,
T5359 375-378 Protein denotes PCR
T5358 63-67 Protein denotes Sox6
T5357 83-101 Protein denotes The ɛy globin gene
T5356 845-893 Protein denotes the other two embryonic globin genes (ζ and βh1)
T5355 654-665 Protein denotes mutant mice
T5354 859-868 Protein denotes embryonic
T5353 462-480 Protein denotes other globin genes
T5352 883-884 Protein denotes ζ
T5351 845-893 Protein denotes the other two embryonic globin genes (ζ and βh1)
T5350 1001-1010 Protein denotes ɛy globin
T5349 63-82 Protein denotes Sox6-Deficient Mice
T5348 220-235 Protein denotes Sox6 downstream
T5347 130-243 Protein denotes an upregulated transcript in the p 100H mouse using subtractive hybridization to identify Sox6 downstream targets
T5346 1111-1132 Protein denotes p100H homozygous mice
R3865 T5347 T5400 themeOf an upregulated transcript in the p 100H mouse using subtractive hybridization to identify Sox6 downstream targets,an upregulated transcript in the p 100H mouse using subtractive hybridization to identify Sox6 downstream targets
R3866 T5360 T5395 themeOf "of the Embryonic Globin, ɛy,","Persistent Expression of the Embryonic Globin, ɛy, in Sox6-Deficient Mice"
R3867 T5371 T5396 themeOf the ɛy gene,"in Figure 1, the ɛy gene is expressed at high levels"
R3868 T5385 T5399 themeOf ɛy,ɛy expression in the livers of 15.5 dpc and 18.5 dpc homozygous mutant mice
R3869 T5387 T5397 themeOf globin,us from evaluating postnatal globin expression
R4850 T6813 T6880 themeOf with CtBP2,the interaction with CtBP2
R4851 T6822 T6877 themeOf CtBP2,CtBP2 is expressed in GM979 cells (unpublished data)
R4852 T6835 T6881 themeOf CtBP2,Sox6-CtBP2 interaction [5]
R4853 T6836 T6832 partOf "the ɛy promoter in the transfection assay (Figure 2B),",ɛy
R4854 T6838 T6821 partOf the ɛy proximal promoter,ɛy
R4855 T6839 T6878 themeOf of Sox6,Overexpression of Sox6 in GM979 cells by transient transfection
R4856 T6839 T6879 themeOf of Sox6,Overexpression of Sox6 in GM979 cells by transient transfection
R4857 T6846 T6833 partOf the ɛy promoter,ɛy
R4858 T6850 T6829 partOf the fgf-3 promoter [5],the fgf-3 promoter [5]
R4859 T6851 T6856 partOf the ɛy promoter,ɛy
R4860 T6852 T6849 partOf the ɛy proximal promoter (2.2 kb),ɛy
R4861 T6873 T6864 partOf of the ɛy promoter,ɛy
R4862 T6874 T6827 partOf of the ɛy promoter,ɛy
R4863 T6875 T6876 partOf of the ɛy promoter,ɛy
R6168 T8755 T8782 partOf "the ɛy promoter,",ɛy
R6170 T8757 T8858 themeOf Sox/Sox6,putative Sox/Sox6 binding sites (M1 and M3) abolish
R6173 T8762 T8778 partOf the ɛy promoter,ɛy
R6177 T8769 T8852 themeOf by the tagged Sox6 protein,by the tagged Sox6 protein
R6178 T8770 T8764 partOf the ɛy promoter defined by the deletion analysis experiments (Figure 2C),ɛy
R6181 T8774 T8853 themeOf Sox6,Sox6 directly binds to this DNA sequence in MEL cells (Figure 3D)
R6186 T8784 T8776 partOf to the ɛy Promoter,ɛy
R6187 T8784 T8849 themeOf to the ɛy Promoter,EMSA and ChIP Assays Show that Sox6 Directly Binds to the ɛy Promoter
R6188 T8785 T8771 partOf the mutant ɛy promoter reporter constructs,ɛy
R6190 T8817 T8854 themeOf binding sites,binding sites
R6191 T8790 T8768 partOf the ɛy promoter reporter constructs with mutagenized Sox/Sox6,ɛy
R6192 T8795 T8855 themeOf The intact consensus Sox/Sox6 binding sites of the DNA probe,The intact consensus Sox/Sox6 binding sites of the DNA probe
R6193 T8798 T8825 partOf of the ɛy promoter,ɛy
R6194 T8799 T8828 partOf to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP),ɛy
R6195 T8799 T8857 themeOf to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP),We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP)
R6196 T8800 T8844 partOf with the ɛy promoter,ɛy
R6197 T8800 T8850 themeOf with the ɛy promoter,Sox6 is directly associated with the ɛy promoter
R6198 T8801 T8857 themeOf Sox6,We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP)
R6199 T8829 T8849 themeOf Sox6,EMSA and ChIP Assays Show that Sox6 Directly Binds to the ɛy Promoter
R6200 T8805 T8851 themeOf two consensus Sox/Sox6 binding sites,two consensus Sox/Sox6 binding sites
R6201 T8834 T8850 themeOf Sox6,Sox6 is directly associated with the ɛy promoter
R6202 T8839 T8856 themeOf to the ɛy,directly binding to the ɛy
R6734 T9650 T9679 themeOf of ɛy globin,the persistent expression of ɛy globin
R6735 T9654 T9676 themeOf of βmaj/min globin,the expression of βmaj/min globin
R6736 T9656 T9683 locationOf definitive erythrocytes,of ɛy globin in definitive erythrocytes
R6737 T9658 T9684 themeOf ɛy globin,"ɛy globin is not expressed in the WT 14.5-dpc liver,"
R6738 T9664 T9677 themeOf mRNA,"In contrast, abundant ectopic ɛy mRNA expression is seen in the liver of 14.5-dpc mutants"
R6739 T9664 T9678 themeOf mRNA,"In contrast, abundant ectopic ɛy mRNA expression is seen in the liver of 14.5-dpc mutants"
R6740 T9667 T9682 themeOf the ɛy globin gene,the ɛy globin gene is exclusively expressed in primitive erythrocytes and silenced in definitive erythrocytes
R6741 T9667 T9685 themeOf the ɛy globin gene,the ɛy globin gene is exclusively expressed in primitive erythrocytes and silenced in definitive erythrocytes
R6742 T9672 T9680 themeOf of ɛy globin in definitive erythrocytes,ectopic expression of ɛy globin in definitive erythrocytes
R6743 T9672 T9683 themeOf of ɛy globin in definitive erythrocytes,of ɛy globin in definitive erythrocytes
R6744 T9673 T9681 themeOf of ɛy Globin,The Persistent Expression of ɛy Globin in Sox6-Deficient
R7150 T10292 T10303 themeOf Sox6,"in situ hybridization shows that Sox6 is highly transcribed in 12.5-dpc liver, but not in yolk sac blood islands at 7.5 dpc (Figure 6B)"
R7151 T10302 T10304 themeOf Sox6,Sox6 expression
R7432 T10674 T10677 themeOf the ɛy globin gene,"silencing the ɛy globin gene,"

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T10267 15010-15011 . denotes .
T10654 16775-16776 . denotes .
T10653 16765-16775 NN denotes maturation
T10652 16760-16764 NN denotes cell
T10651 16756-16759 JJ denotes red
T10266 14996-15010 NNS denotes erythropoiesis
T10265 14985-14995 JJ denotes definitive
T10264 14982-14984 IN denotes in
T10263 14972-14981 NNS denotes functions
T10262 14967-14971 JJ denotes Sox6
T10261 14962-14966 IN denotes that
T10260 14950-14961 VBP denotes demonstrate
T10259 14948-14949 , denotes ,
T10258 14947-14948 -RRB- denotes )
T10257 14946-14947 CD denotes 5
T10256 14939-14945 NN denotes Figure
T10255 14938-14939 -LRB- denotes (
T10254 14933-14937 NNS denotes mice
T10253 14926-14932 JJ denotes mutant
T10252 14920-14925 JJ denotes p100H
T10251 14911-14919 JJ denotes 14.5-dpc
T10250 14908-14910 IN denotes of
T10249 14902-14907 NNS denotes cells
T10248 14896-14901 NN denotes liver
T10247 14892-14895 DT denotes the
T10246 14889-14891 IN denotes in
T10245 14879-14888 VBN denotes expressed
T10244 14872-14878 RB denotes highly
T10243 14869-14871 VBZ denotes is
T10242 14862-14868 NN denotes globin
T10241 14859-14861 JJ denotes ɛy
T10240 14854-14858 IN denotes that
T10239 14842-14853 NN denotes observation
T10238 14838-14841 DT denotes the
T10237 14833-14837 IN denotes with
T10236 14824-14832 RB denotes together
T10235 14818-14823 VBN denotes taken
T10234 14816-14817 , denotes ,
T10233 14812-14816 NNS denotes data
T10232 14806-14811 DT denotes These
T10231 14804-14805 . denotes .
T10230 14790-14804 NNS denotes erythropoiesis
T10229 14788-14789 , denotes ,
T10228 14779-14788 JJ denotes primitive
T10227 14775-14778 RB denotes not
T10226 14771-14774 CC denotes but
T10225 14769-14770 , denotes ,
T10224 14759-14769 JJ denotes definitive
T10223 14754-14758 IN denotes with
T10222 14743-14753 JJ denotes coincident
T10221 14733-14742 RB denotes spatially
T10220 14729-14732 CC denotes and
T10219 14718-14728 RB denotes temporally
T10218 14715-14717 VBZ denotes is
T10217 14704-14714 NN denotes expression
T10216 14699-14703 JJ denotes Sox6
T10215 14697-14698 , denotes ,
T10214 14688-14697 RB denotes Therefore
T10213 14686-14687 . denotes .
T10212 14685-14686 -RRB- denotes )
T10211 14683-14685 NN denotes 6B
T10210 14676-14682 NN denotes Figure
T10209 14675-14676 -LRB- denotes (
T10208 14671-14674 NN denotes dpc
T10207 14667-14670 CD denotes 7.5
T10206 14664-14666 IN denotes at
T10205 14656-14663 NNS denotes islands
T10204 14650-14655 NN denotes blood
T10203 14646-14649 NN denotes sac
T10202 14641-14645 NN denotes yolk
T10201 14638-14640 IN denotes in
T10200 14634-14637 RB denotes not
T10199 14630-14633 CC denotes but
T10198 14628-14629 , denotes ,
T10197 14623-14628 NN denotes liver
T10196 14614-14622 JJ denotes 12.5-dpc
T10195 14611-14613 IN denotes in
T10194 14599-14610 VBN denotes transcribed
T10193 14592-14598 RB denotes highly
T10192 14589-14591 VBZ denotes is
T10191 14584-14588 NNP denotes Sox6
T10190 14579-14583 IN denotes that
T10189 14573-14578 VBZ denotes shows
T10188 14559-14572 NN denotes hybridization
T10187 14554-14558 NN denotes situ
T10186 14551-14553 IN denotes in
T10185 14549-14550 , denotes ,
T10184 14538-14549 RB denotes Furthermore
T10183 14536-14537 . denotes .
T10182 14531-14536 NN denotes liver
T10181 14527-14530 DT denotes the
T10180 14524-14526 IN denotes in
T10179 14509-14523 NNS denotes erythropoiesis
T10178 14498-14508 JJ denotes definitive
T10177 14495-14497 IN denotes of
T10176 14489-14494 NN denotes onset
T10175 14480-14488 JJ denotes temporal
T10174 14476-14479 DT denotes the
T10173 14471-14475 IN denotes with
T10172 14460-14470 JJ denotes coincident
T10171 14458-14459 , denotes ,
T10170 14455-14458 NN denotes dpc
T10169 14450-14454 CD denotes 10.5
T10168 14447-14449 IN denotes at
T10167 14437-14446 NN denotes beginning
T10166 14432-14436 NN denotes blot
T10165 14423-14431 NNP denotes Northern
T10164 14420-14422 IN denotes by
T10163 14409-14419 JJ denotes detectable
T10162 14406-14408 VBZ denotes is
T10161 14401-14405 NNP denotes Sox6
T10160 14399-14400 , denotes ,
T10159 14397-14399 CD denotes 6A
T10158 14390-14396 NN denotes Figure
T10157 14387-14389 IN denotes in
T10156 14381-14386 VBN denotes shown
T10155 14378-14380 IN denotes As
T10154 14376-14377 . denotes .
T10153 14368-14376 VBN denotes employed
T10152 14363-14367 VBD denotes were
T10151 14356-14362 NNS denotes assays
T10150 14342-14355 NN denotes hybridization
T10149 14337-14341 NN denotes situ
T10148 14334-14336 IN denotes in
T10147 14330-14333 CC denotes and
T10146 14325-14329 NN denotes blot
T10145 14316-14324 NNP denotes Northern
T10144 14314-14315 , denotes ,
T10143 14310-14314 NNP denotes Sox6
T10142 14307-14309 IN denotes of
T10109 14089-14093 NNS denotes mice
T10108 14074-14088 JJ denotes Sox6-deficient
T10107 14069-14073 WDT denotes that
T10106 14057-14068 NN denotes observation
T10105 14053-14056 DT denotes The
T10104 14038-14052 NNPS denotes Erythropoiesis
T10103 14027-14037 JJ denotes Definitive
T10102 14024-14026 IN denotes in
T10101 14019-14023 NN denotes Role
T10100 14017-14018 DT denotes a
T10099 14008-14016 VBZ denotes Suggests
T10098 14003-14007 NNP denotes Sox6
T10097 14000-14002 IN denotes of
T10096 13992-13999 NNP denotes Pattern
T10095 13981-13991 NNP denotes Expression
T10094 13977-13980 DT denotes The
T10650 16749-16755 VB denotes affect
T10649 16745-16748 MD denotes may
T10648 16740-16744 NNP denotes Sox6
T10647 16738-16739 , denotes ,
T10646 16734-16738 NN denotes gene
T10645 16727-16733 NN denotes globin
T10644 16724-16726 JJ denotes ɛy
T10643 16720-16723 DT denotes the
T10642 16710-16719 VBG denotes silencing
T10641 16702-16709 IN denotes besides
T10640 16697-16701 IN denotes that
T10639 16689-16696 VBP denotes suggest
T10638 16676-16688 NNS denotes observations
T10637 16670-16675 DT denotes These
T10636 16668-16669 . denotes .
T10635 16665-16668 NN denotes dpc
T10634 16660-16664 CD denotes 14.5
T10633 16657-16659 IN denotes as
T10632 16651-16656 JJ denotes early
T10631 16648-16650 IN denotes as
T10630 16642-16647 VBN denotes noted
T10629 16639-16641 VBZ denotes is
T10628 16628-16638 NN denotes alteration
T10627 16623-16627 DT denotes This
T10626 16621-16622 . denotes .
T10625 16620-16621 -RRB- denotes )
T10624 16618-16620 NN denotes 7B
T10623 16611-16617 NN denotes Figure
T10622 16610-16611 -LRB- denotes (
T10621 16606-16609 NN denotes dpc
T10620 16601-16605 CD denotes 18.5
T10619 16598-16600 IN denotes at
T10618 16585-16597 NNS denotes erythrocytes
T10617 16575-16584 JJ denotes nucleated
T10616 16565-16574 VBG denotes including
T10615 16559-16564 NNS denotes cells
T10614 16549-16558 NN denotes precursor
T10613 16535-16548 JJ denotes hematopoietic
T10612 16532-16534 IN denotes in
T10611 16523-16531 NN denotes increase
T10610 16511-16522 JJ denotes significant
T10609 16509-16510 DT denotes a
T10608 16503-16508 VBZ denotes shows
T10607 16497-16502 NN denotes liver
T10606 16490-16496 JJ denotes mutant
T10605 16486-16489 DT denotes the
T10604 16484-16485 , denotes ,
T10603 16476-16484 NN denotes addition
T10602 16473-16475 IN denotes In
T10601 16471-16472 . denotes .
T10600 16465-16471 NN denotes effect
T10599 16455-16464 JJ denotes transient
T10598 16453-16454 DT denotes a
T10597 16450-16452 VB denotes be
T10596 16446-16449 MD denotes may
T10595 16441-16445 DT denotes this
T10594 16436-16440 IN denotes that
T10593 16425-16435 VBG denotes suggesting
T10592 16423-16424 , denotes ,
T10591 16419-16423 NNS denotes mice
T10590 16412-16418 JJ denotes mutant
T10589 16409-16411 CC denotes or
T10588 16406-16408 NNP denotes WT
T10587 16399-16405 DT denotes either
T10586 16396-16398 IN denotes in
T10585 16390-16395 NNS denotes cells
T10584 16386-16389 JJ denotes red
T10547 16205-16214 JJ denotes nucleated
T10546 16200-16204 RBR denotes more
T10545 16196-16199 VBP denotes are
T10544 16190-16195 EX denotes there
T10543 16185-16189 IN denotes that
T10542 16177-16184 VBN denotes noticed
T10541 16172-16176 VBP denotes have
T10540 16169-16171 PRP denotes we
T10539 16167-16168 , denotes ,
T10538 16153-16167 NN denotes erythropoiesis
T10537 16150-16152 IN denotes in
T10536 16142-16149 NNS denotes effects
T10535 16137-16141 JJ denotes Sox6
T10534 16131-16136 JJ denotes other
T10533 16127-16130 DT denotes the
T10532 16121-16126 IN denotes Among
T10531 16115-16120 NNP denotes Cells
T10530 16111-16114 NNP denotes Red
T10529 16101-16110 NNP denotes Nucleated
T10528 16098-16100 IN denotes of
T10527 16090-16097 NNS denotes Numbers
T10526 16083-16089 JJR denotes Higher
T10525 16078-16082 NNP denotes Have
T10524 16073-16077 NNP denotes Mice
T10523 16067-16072 NNP denotes p100H
T10522 16060-16066 JJ denotes Mutant
T10583 16376-16385 JJ denotes nucleated
T10582 16364-16375 VBG denotes circulating
T10581 16360-16363 VB denotes see
T10580 16356-16359 RB denotes not
T10579 16353-16355 VBP denotes do
T10578 16350-16352 PRP denotes we
T10577 16348-16349 , denotes ,
T10576 16344-16348 CD denotes 10.5
T10575 16340-16343 NN denotes day
T10574 16330-16339 JJ denotes postnatal
T10573 16327-16329 IN denotes at
T10572 16325-16326 , denotes ,
T10571 16318-16325 RB denotes However
T10570 16316-16317 . denotes .
T10569 16315-16316 -RRB- denotes )
T10568 16313-16315 NN denotes 7A
T10567 16306-16312 NN denotes Figure
T10566 16305-16306 -LRB- denotes (
T10565 16301-16304 NN denotes dpc
T10564 16296-16300 CD denotes 18.5
T10563 16292-16295 CC denotes and
T10562 16288-16291 NN denotes dpc
T10561 16283-16287 CD denotes 14.5
T10560 16280-16282 IN denotes at
T10559 16275-16279 NNS denotes mice
T10558 16272-16274 NNP denotes WT
T10557 16269-16271 IN denotes in
T10556 16264-16268 IN denotes than
T10555 16259-16263 NNS denotes mice
T10554 16252-16258 JJ denotes mutant
T10553 16246-16251 JJ denotes p100H
T10552 16243-16245 IN denotes in
T10551 16231-16242 VBG denotes circulating
T10550 16225-16230 NNS denotes cells
T10549 16219-16224 NN denotes blood
T10548 16215-16218 JJ denotes red
T10141 14299-14306 NN denotes pattern
T10140 14288-14298 NN denotes expression
T10139 14280-14287 JJ denotes spatial
T10138 14276-14279 CC denotes and
T10137 14267-14275 JJ denotes temporal
T10136 14263-14266 DT denotes the
T10135 14253-14262 VB denotes determine
T10134 14250-14252 TO denotes To
T10133 14248-14249 . denotes .
T10132 14234-14248 NNS denotes erythropoiesis
T10131 14223-14233 JJ denotes definitive
T10130 14220-14222 IN denotes in
T10129 14210-14219 NN denotes regulator
T10128 14200-14209 JJ denotes important
T10127 14197-14199 DT denotes an
T10126 14194-14196 VBZ denotes is
T10125 14189-14193 NNP denotes Sox6
T10124 14184-14188 IN denotes that
T10123 14175-14183 VBZ denotes suggests
T10122 14173-14174 , denotes ,
T10121 14167-14173 VBP denotes mature
T10120 14161-14166 NNS denotes cells
T10119 14151-14160 JJ denotes erythroid
T10118 14140-14150 JJ denotes definitive
T10117 14134-14139 WRB denotes where
T10116 14132-14133 , denotes ,
T10115 14127-14132 NN denotes liver
T10114 14124-14126 IN denotes in
T10113 14117-14123 NN denotes globin
T10112 14114-14116 JJ denotes ɛy
T10111 14106-14113 VBP denotes express
T10110 14094-14105 RB denotes ectopically
T9586 13108-13119 VBP denotes demonstrate
T9585 13103-13107 NNS denotes data
T9584 13097-13102 DT denotes These
T9583 13095-13096 . denotes .
T9582 13094-13095 -RRB- denotes )
T9581 13093-13094 NN denotes F
T9580 13089-13092 CC denotes and
T9579 13087-13088 NNP denotes E
T9578 13085-13086 CD denotes 5
T9577 13078-13084 NN denotes Figure
T9576 13077-13078 -LRB- denotes (
T9575 13072-13076 NNS denotes mice
T9574 13065-13071 JJ denotes mutant
T9573 13059-13064 NNP denotes p100H
T9572 13055-13058 CC denotes and
T9571 13052-13054 NNP denotes WT
T9570 13047-13051 DT denotes both
T9569 13044-13046 IN denotes in
T9568 13035-13043 JJ denotes abundant
T9567 13027-13034 RB denotes equally
T9566 13024-13026 VBZ denotes is
T9565 13017-13023 NN denotes globin
T9564 13013-13016 NN denotes min
T9563 13012-13013 NN denotes /
T9562 13008-13012 NN denotes βmaj
T9561 13005-13007 IN denotes of
T9560 12994-13004 NN denotes expression
T9559 12990-12993 DT denotes the
T9558 12988-12989 , denotes ,
T9557 12981-12988 RB denotes However
T9556 12979-12980 . denotes .
T9555 12978-12979 -RRB- denotes )
T9554 12977-12978 NNP denotes D
T9553 12975-12976 DT denotes A
T9552 12973-12974 CD denotes 5
T9551 12966-12972 NN denotes Figure
T9550 12965-12966 -LRB- denotes (
T9549 12957-12964 NNS denotes mutants
T9548 12948-12956 JJ denotes 14.5-dpc
T9547 12945-12947 IN denotes of
T9546 12939-12944 NN denotes liver
T9545 12935-12938 DT denotes the
T9544 12932-12934 IN denotes in
T9543 12927-12931 VBN denotes seen
T9542 12924-12926 VBZ denotes is
T9541 12913-12923 NN denotes expression
T9540 12908-12912 NNP denotes mRNA
T9539 12905-12907 NN denotes ɛy
T9538 12897-12904 JJ denotes ectopic
T9537 12888-12896 JJ denotes abundant
T9536 12886-12887 , denotes ,
T9535 12878-12886 NN denotes contrast
T9534 12875-12877 IN denotes In
T9533 12873-12874 . denotes .
T9532 12868-12873 NN denotes fetus
T9531 12864-12867 DT denotes the
T9530 12861-12863 IN denotes in
T9529 12846-12860 NNS denotes erythropoiesis
T9528 12835-12845 JJ denotes definitive
T9527 12832-12834 IN denotes of
T9526 12827-12831 NN denotes site
T9525 12823-12826 DT denotes the
T9524 12821-12822 , denotes ,
T9523 12816-12821 NN denotes liver
T9522 12807-12815 JJ denotes 14.5-dpc
T9521 12804-12806 NNP denotes WT
T9520 12800-12803 DT denotes the
T9519 12797-12799 IN denotes in
T9518 12787-12796 VBN denotes expressed
T9517 12783-12786 RB denotes not
T9516 12780-12782 VBZ denotes is
T9515 12773-12779 NN denotes globin
T9514 12770-12772 JJ denotes ɛy
T9513 12768-12769 , denotes ,
T9512 12760-12768 VBN denotes expected
T9511 12757-12759 IN denotes As
T9510 12755-12756 . denotes .
T9509 12754-12755 -RRB- denotes )
T9508 12753-12754 CD denotes 5
T9507 12746-12752 NN denotes Figure
T9506 12745-12746 -LRB- denotes (
T9505 12731-12744 NN denotes hybridization
T9504 12726-12730 NN denotes situ
T9503 12723-12725 IN denotes in
T9502 12720-12722 IN denotes by
T9501 12712-12719 NNS denotes embryos
T9500 12706-12711 NN denotes mouse
T9499 12703-12705 IN denotes in
T9498 12691-12702 NNS denotes transcripts
T9497 12684-12690 NN denotes globin
T9496 12681-12683 JJ denotes ɛy
T9495 12678-12680 IN denotes of
T9494 12670-12677 NN denotes pattern
T9493 12662-12669 JJ denotes spatial
T9492 12658-12661 DT denotes the
T9491 12649-12657 VBD denotes examined
T9490 12646-12648 PRP denotes we
T9489 12644-12645 , denotes ,
T9488 12632-12644 NNS denotes erythrocytes
T9487 12621-12631 JJ denotes definitive
T9486 12618-12620 IN denotes in
T9485 12611-12617 NN denotes globin
T9484 12608-12610 JJ denotes ɛy
T9483 12605-12607 IN denotes of
T9482 12594-12604 NN denotes expression
T9481 12586-12593 JJ denotes ectopic
T9480 12583-12585 TO denotes to
T9479 12579-12582 JJ denotes due
T9478 12576-12578 VBZ denotes is
T9477 12573-12575 CC denotes or
T9476 12560-12572 NNS denotes erythrocytes
T9475 12550-12559 JJ denotes primitive
T9474 12541-12549 JJ denotes residual
T9473 12538-12540 TO denotes to
T9472 12534-12537 JJ denotes due
T9471 12531-12533 VBZ denotes is
T9470 12524-12530 NN denotes globin
T9469 12521-12523 JJ denotes ɛy
T9468 12518-12520 IN denotes of
T9467 12507-12517 NN denotes expression
T9466 12496-12506 JJ denotes persistent
T9465 12492-12495 DT denotes the
T9464 12484-12491 IN denotes whether
T9463 12474-12483 VB denotes determine
T9462 12471-12473 TO denotes To
T9461 12469-12470 . denotes .
T9460 12457-12469 NNS denotes erythrocytes
T9459 12446-12456 JJ denotes definitive
T9458 12443-12445 IN denotes in
T9457 12434-12442 VBN denotes silenced
T9456 12430-12433 CC denotes and
T9455 12417-12429 NNS denotes erythrocytes
T9454 12407-12416 JJ denotes primitive
T9453 12404-12406 IN denotes in
T9452 12394-12403 VBN denotes expressed
T9451 12382-12393 RB denotes exclusively
T9450 12379-12381 VBZ denotes is
T9449 12374-12378 NN denotes gene
T9448 12367-12373 NN denotes globin
T9447 12364-12366 JJ denotes ɛy
T9446 12360-12363 DT denotes the
T9445 12358-12359 , denotes ,
T9444 12350-12358 NNP denotes Normally
T9443 12344-12349 NNP denotes Cells
T9442 12334-12343 NNP denotes Erythroid
T9441 12323-12333 NNP denotes Definitive
T9440 12320-12322 IN denotes in
T9439 12310-12319 NNP denotes Mechanism
T9438 12300-12309 VBG denotes Silencing
T9437 12292-12299 JJ denotes ɛy-Gene
T9436 12288-12291 DT denotes the
T9435 12285-12287 IN denotes in
T9434 12278-12284 NN denotes Defect
T9433 12276-12277 DT denotes a
T9432 12273-12275 TO denotes to
T9431 12269-12272 JJ denotes Due
T9430 12266-12268 VBZ denotes Is
T9429 12261-12265 NNP denotes Mice
T9428 12246-12260 NNP denotes Sox6-Deficient
T9427 12243-12245 IN denotes in
T9426 12236-12242 NNP denotes Globin
T9425 12233-12235 NNP denotes ɛy
T9424 12230-12232 IN denotes of
T9423 12219-12229 NNP denotes Expression
T9422 12208-12218 NNP denotes Persistent
T9421 12204-12207 DT denotes The
T9626 13346-13347 . denotes .
T9625 13342-13346 NNS denotes mice
T9624 13332-13341 JJ denotes Sox6-null
T9623 13329-13331 IN denotes in
T9622 13319-13328 NN denotes mechanism
T9621 13309-13318 VBG denotes silencing
T9620 13306-13308 NN denotes ɛy
T9619 13302-13305 DT denotes the
T9618 13299-13301 IN denotes of
T9617 13292-13298 NN denotes defect
T9616 13282-13291 JJ denotes intrinsic
T9615 13279-13281 DT denotes an
T9614 13276-13278 VBZ denotes is
T9613 13270-13275 EX denotes there
T9612 13265-13269 IN denotes that
T9611 13254-13264 VBG denotes suggesting
T9610 13252-13253 , denotes ,
T9609 13247-13252 NN denotes liver
T9608 13241-13246 JJ denotes fetal
T9607 13237-13240 DT denotes the
T9606 13234-13236 IN denotes in
T9605 13227-13233 VBP denotes mature
T9604 13222-13226 WDT denotes that
T9603 13216-13221 NNS denotes cells
T9602 13206-13215 JJ denotes erythroid
T9601 13195-13205 JJ denotes definitive
T9600 13191-13194 DT denotes the
T9599 13188-13190 IN denotes in
T9598 13177-13187 NN denotes expression
T9597 13169-13176 JJ denotes ectopic
T9596 13166-13168 TO denotes to
T9595 13162-13165 JJ denotes due
T9594 13158-13161 VBP denotes are
T9593 13155-13157 NN denotes ɛy
T9592 13152-13154 IN denotes of
T9591 13145-13151 NNS denotes levels
T9590 13140-13144 JJ denotes high
T9589 13129-13139 JJ denotes persistent
T9588 13125-13128 DT denotes the
T9587 13120-13124 IN denotes that
T8697 11374-11375 . denotes .
T8696 11369-11374 NN denotes dimer
T8695 11367-11368 DT denotes a
T8694 11364-11366 IN denotes as
T8693 11355-11363 RB denotes probably
T8692 11353-11354 , denotes ,
T8691 11345-11353 NN denotes promoter
T8690 11342-11344 JJ denotes ɛy
T8689 11338-11341 DT denotes the
T8688 11335-11337 TO denotes to
T8687 11327-11334 JJ denotes binding
T8686 11318-11326 RB denotes directly
T8685 11315-11317 IN denotes by
T8684 11310-11314 NN denotes gene
T8683 11307-11309 JJ denotes ɛy
T8682 11303-11306 DT denotes the
T8681 11300-11302 IN denotes of
T8680 11290-11299 NN denotes repressor
T8679 11288-11289 DT denotes a
T8678 11285-11287 IN denotes as
T8677 11280-11284 NNS denotes acts
T8676 11275-11279 JJ denotes Sox6
T8675 11270-11274 IN denotes that
T8674 11261-11269 VBP denotes indicate
T8673 11253-11260 RB denotes clearly
T8672 11251-11252 -RRB- denotes )
T8671 11250-11251 CD denotes 4
T8670 11246-11249 CC denotes and
T8669 11244-11245 CD denotes 3
T8668 11236-11243 NNS denotes Figures
T8667 11235-11236 -LRB- denotes (
T8666 11230-11234 NNS denotes data
T8665 11224-11229 IN denotes above
T8664 11220-11223 DT denotes The
T8663 11218-11219 . denotes .
T8662 11217-11218 -RRB- denotes )
T8661 11215-11217 NN denotes 4A
T8660 11208-11214 NN denotes Figure
T8659 11207-11208 -LRB- denotes (
T8658 11199-11206 NN denotes control
T8657 11190-11198 JJ denotes negative
T8656 11188-11189 DT denotes a
T8655 11185-11187 IN denotes as
T8654 11180-11184 VBN denotes used
T8653 11176-11179 VBD denotes was
T8652 11172-11175 NNP denotes IgG
T8651 11165-11171 JJ denotes Normal
T8650 11163-11164 . denotes .
T8649 11158-11163 NNS denotes cells
T8648 11152-11157 NN denotes liver
T8647 11148-11151 CC denotes and
T8646 11142-11147 NNS denotes cells
T8645 11138-11141 NNP denotes MEL
T8644 11133-11137 DT denotes both
T8643 11130-11132 IN denotes in
T8642 11121-11129 NN denotes antibody
T8641 11116-11120 JJ denotes Sox6
T8640 11111-11115 IN denotes with
T8639 11092-11110 VBN denotes immunoprecipitated
T8638 11084-11091 RB denotes readily
T8637 11081-11083 VBZ denotes is
T8636 11072-11080 NN denotes promoter
T8635 11063-11071 JJ denotes proximal
T8634 11060-11062 JJ denotes ɛy
T8633 11056-11059 DT denotes the
T8632 11051-11055 IN denotes that
T8631 11045-11050 NNS denotes shows
T8630 11043-11044 CD denotes 4
T8629 11036-11042 NN denotes Figure
T8628 11034-11035 . denotes .
T8627 11026-11034 NN denotes antibody
T8626 11021-11025 JJ denotes Sox6
T8625 11015-11020 VBG denotes using
T8624 11010-11014 NNS denotes mice
T8623 11007-11009 NNP denotes WT
T8622 11003-11006 NN denotes dpc
T8621 10998-11002 CD denotes 15.5
T8620 10995-10997 IN denotes of
T8619 10989-10994 NNS denotes cells
T8618 10983-10988 NN denotes liver
T8617 10978-10982 IN denotes from
T8616 10975-10977 CC denotes or
T8615 10969-10974 NNS denotes cells
T8614 10965-10968 NNP denotes MEL
T8613 10960-10964 IN denotes from
T8612 10941-10959 VBN denotes immunoprecipitated
T8611 10937-10940 VBD denotes was
T8610 10929-10936 NN denotes complex
T8609 10913-10928 JJ denotes Sox6-containing
T8608 10909-10912 DT denotes The
T8607 10907-10908 . denotes .
T8606 10906-10907 -RRB- denotes )
T8605 10905-10906 CD denotes 4
T8604 10898-10904 NN denotes Figure
T8603 10897-10898 -LRB- denotes (
T8602 10895-10896 -RRB- denotes )
T8601 10891-10895 NNP denotes ChIP
T8600 10890-10891 -LRB- denotes (
T8599 10870-10889 NN denotes immunoprecipitation
T8598 10860-10869 NN denotes chromatin
T8597 10854-10859 VBG denotes using
T8596 10849-10853 NN denotes vivo
T8595 10846-10848 IN denotes in
T8594 10837-10845 NN denotes promoter
T8593 10834-10836 JJ denotes ɛy
T8592 10830-10833 DT denotes the
T8591 10827-10829 TO denotes to
T8590 10821-10826 NNS denotes binds
T8589 10816-10820 JJ denotes Sox6
T8588 10808-10815 IN denotes whether
T8587 10801-10807 VBD denotes tested
T8586 10796-10800 RB denotes also
T8585 10793-10795 PRP denotes We
T8584 10791-10792 . denotes .
T8583 10785-10791 NN denotes degree
T8582 10780-10784 JJ denotes same
T8581 10776-10779 DT denotes the
T8580 10773-10775 TO denotes to
T8579 10769-10772 RB denotes not
T8578 10765-10768 CC denotes but
T8577 10763-10764 , denotes ,
T8576 10759-10763 NNP denotes Sox6
T8575 10756-10758 IN denotes by
T8574 10753-10755 NN denotes ɛy
T8573 10750-10752 IN denotes of
T8572 10739-10749 NN denotes repression
T8571 10731-10738 JJ denotes maximal
T8570 10727-10730 IN denotes for
T8569 10718-10726 VBN denotes required
T8568 10714-10717 VBP denotes are
T8567 10708-10713 NNS denotes sites
T8566 10703-10707 DT denotes both
T8565 10701-10702 , denotes ,
T8564 10697-10701 RB denotes Thus
T8563 10695-10696 . denotes .
T8562 10694-10695 -RRB- denotes )
T8561 10692-10694 CD denotes 3F
T8560 10685-10691 NN denotes Figure
T8559 10684-10685 -LRB- denotes (
T8558 10676-10683 NNS denotes studies
T8557 10663-10675 NN denotes transfection
T8556 10660-10662 IN denotes in
T8555 10649-10659 NN denotes repression
T8554 10640-10648 NN denotes promoter
T8553 10628-10639 JJ denotes significant
T8552 10625-10627 IN denotes in
T8551 10618-10624 VB denotes result
T8550 10614-10617 RB denotes not
T8549 10611-10613 VBP denotes do
T8548 10609-10610 -RRB- denotes )
T8547 10598-10609 VBN denotes mutagenized
T8546 10592-10597 NNS denotes sites
T8545 10584-10591 JJ denotes binding
T8544 10575-10583 JJ denotes Sox/Sox6
T8543 10570-10574 DT denotes both
T8542 10567-10569 CC denotes or
T8541 10563-10566 CD denotes one
T8540 10556-10562 DT denotes either
T8539 10551-10555 IN denotes with
T8538 10550-10551 -LRB- denotes (
T8537 10539-10549 NNS denotes constructs
T8536 10530-10538 NN denotes reporter
T8535 10521-10529 NN denotes promoter
T8534 10518-10520 NN denotes ɛy
T8533 10511-10517 JJ denotes mutant
T8532 10507-10510 DT denotes the
T8531 10505-10506 , denotes ,
T8530 10498-10505 NNS denotes results
T8529 10493-10497 NNP denotes EMSA
T8528 10489-10492 DT denotes the
T8527 10484-10488 IN denotes with
T8526 10473-10483 JJ denotes Consistent
T8525 10471-10472 . denotes .
T8524 10466-10471 NNS denotes cells
T8523 10460-10465 NNP denotes GM979
T8522 10455-10459 IN denotes into
T8521 10448-10454 NN denotes vector
T8520 10433-10447 NN denotes overexpression
T8519 10428-10432 JJ denotes Sox6
T8518 10424-10427 DT denotes the
T8517 10419-10423 IN denotes with
T8516 10404-10418 VBN denotes co-transfected
T8515 10399-10403 VBD denotes were
T8514 10393-10398 NNS denotes sites
T8513 10385-10392 JJ denotes binding
T8512 10376-10384 NNP denotes Sox/Sox6
T8511 10364-10375 VBN denotes mutagenized
T8510 10359-10363 IN denotes with
T8509 10348-10358 NNS denotes constructs
T8508 10339-10347 NN denotes reporter
T8507 10330-10338 NN denotes promoter
T8506 10327-10329 JJ denotes ɛy
T8505 10323-10326 DT denotes the
T8504 10321-10322 , denotes ,
T8503 10316-10321 NNS denotes sites
T8502 10308-10315 JJ denotes binding
T8501 10299-10307 NNP denotes Sox/Sox6
T8500 10292-10298 JJ denotes intact
T8499 10288-10291 DT denotes the
T8498 10285-10287 IN denotes of
T8497 10272-10284 NN denotes significance
T8496 10261-10271 JJ denotes functional
T8495 10257-10260 DT denotes the
T8494 10245-10256 VB denotes investigate
T8493 10242-10244 TO denotes To
T8492 10240-10241 . denotes .
T8491 10233-10240 JJ denotes binding
T8490 10230-10232 NNP denotes WT
T8489 10225-10229 IN denotes with
T8488 10215-10224 RB denotes partially
T8487 10207-10214 VB denotes compete
T8486 10203-10206 MD denotes may
T8221 8884-8887 DT denotes The
T8220 8882-8883 . denotes .
T8219 8880-8882 NN denotes 3A
T8218 8873-8879 NN denotes Figure
T8217 8870-8872 IN denotes in
T8216 8863-8869 VBN denotes listed
T8215 8859-8862 VBP denotes are
T8214 8854-8858 VBN denotes used
T8213 8847-8853 NNS denotes probes
T8212 8843-8846 DT denotes The
T8211 8841-8842 . denotes .
T8210 8835-8841 NN denotes system
T8209 8829-8834 NN denotes vitro
T8208 8826-8828 IN denotes in
T8207 8800-8825 NN denotes transcription/translation
T8206 8787-8799 JJ denotes lysate-based
T8205 8774-8786 NN denotes reticulocyte
T8204 8772-8773 DT denotes a
T8203 8769-8771 IN denotes in
T8202 8764-8768 NN denotes Sox6
T8201 8751-8763 JJ denotes c-Myc-tagged
T8200 8749-8750 DT denotes a
T8199 8743-8748 VBG denotes using
T8198 8741-8742 -RRB- denotes )
T8197 8737-8741 NNP denotes EMSA
T8196 8736-8737 -LRB- denotes (
T8195 8729-8735 NNS denotes assays
T8194 8723-8728 NN denotes shift
T8193 8714-8722 NN denotes mobility
T8192 8698-8713 JJ denotes electrophoretic
T8191 8688-8697 VBD denotes performed
T8190 8682-8687 RB denotes first
T8189 8679-8681 PRP denotes we
T8188 8677-8678 , denotes ,
T8187 8669-8677 NN denotes promoter
T8186 8666-8668 JJ denotes ɛy
T8185 8662-8665 DT denotes the
T8184 8657-8661 IN denotes with
T8183 8646-8656 VBN denotes associated
T8182 8637-8645 RB denotes directly
T8181 8634-8636 VBZ denotes is
T8180 8629-8633 NNP denotes Sox6
T8179 8621-8628 IN denotes whether
T8178 8609-8620 VB denotes investigate
T8177 8606-8608 TO denotes To
T8176 8604-8605 . denotes .
T8175 8596-8604 NN denotes promoter
T8174 8593-8595 JJ denotes ɛy
T8173 8589-8592 DT denotes the
T8172 8579-8588 VBG denotes affecting
T8171 8565-8578 NNS denotes intermediates
T8170 8554-8564 VBG denotes regulating
T8169 8551-8553 IN denotes by
T8168 8548-8550 CC denotes or
T8167 8539-8547 NN denotes promoter
T8166 8535-8538 DT denotes the
T8165 8530-8534 IN denotes with
T8164 8522-8529 NN denotes contact
T8163 8513-8521 JJ denotes physical
T8162 8506-8512 JJ denotes direct
T8161 8498-8505 IN denotes through
T8160 8491-8497 CC denotes either
T8159 8489-8490 , denotes ,
T8158 8481-8489 NN denotes promoter
T8157 8478-8480 JJ denotes ɛy
T8156 8474-8477 DT denotes the
T8155 8466-8473 VB denotes repress
T8154 8460-8465 MD denotes might
T8153 8455-8459 NNP denotes Sox6
T8152 8446-8454 NNP denotes Promoter
T8151 8443-8445 NN denotes ɛy
T8150 8439-8442 DT denotes the
T8149 8436-8438 TO denotes to
T8148 8430-8435 VBZ denotes Binds
T8147 8421-8429 RB denotes Directly
T8146 8416-8420 NNP denotes Sox6
T8145 8411-8415 IN denotes that
T8144 8406-8410 NNP denotes Show
T8143 8399-8405 NNP denotes Assays
T8142 8394-8398 NNP denotes ChIP
T8141 8390-8393 CC denotes and
T8140 8385-8389 NNP denotes EMSA
T8411 9855-9858 RB denotes not
T8410 9851-9854 CC denotes but
T8409 9849-9850 , denotes ,
T8408 9842-9849 NNS denotes globins
T8407 9840-9841 NN denotes β
T8406 9834-9839 NN denotes adult
T8405 9826-9833 JJ denotes express
T8404 9824-9825 , denotes ,
T8403 9820-9824 NN denotes line
T8402 9815-9819 NN denotes cell
T8401 9799-9814 JJ denotes erythroleukemic
T8400 9792-9798 JJ denotes murine
T8399 9790-9791 DT denotes a
T8398 9788-9789 , denotes ,
T8397 9783-9788 NNS denotes cells
T8396 9779-9782 NNP denotes MEL
T8395 9777-9778 . denotes .
T8394 9772-9777 NN denotes probe
T8393 9766-9771 JJ denotes 36-bp
T8392 9761-9765 JJ denotes same
T8391 9757-9760 DT denotes the
T8390 9747-9756 VBG denotes employing
T8389 9742-9746 NNP denotes EMSA
T8388 9739-9741 IN denotes in
T8387 9734-9738 VBN denotes used
T8386 9729-9733 VBD denotes were
T8385 9723-9728 NNS denotes cells
T8384 9719-9722 NNP denotes MEL
T8383 9714-9718 IN denotes from
T8382 9705-9713 NNS denotes extracts
T8381 9697-9704 JJ denotes nuclear
T8380 9695-9696 , denotes ,
T8379 9691-9695 JJ denotes Next
T8378 9689-9690 . denotes .
T8377 9688-9689 -RRB- denotes )
T8376 9686-9688 NN denotes 3C
T8375 9679-9685 NN denotes Figure
T8374 9678-9679 -LRB- denotes (
T8373 9670-9677 NNS denotes results
T8372 9664-9669 DT denotes these
T8371 9654-9663 VBD denotes confirmed
T8370 9649-9653 WDT denotes that
T8369 9644-9648 NNP denotes EMSA
T8368 9636-9643 DT denotes another
T8367 9633-9635 IN denotes in
T8366 9628-9632 VBN denotes used
T8365 9624-9627 VBD denotes was
T8364 9619-9623 NN denotes Sox6
T8363 9609-9618 JJ denotes HA-tagged
T8362 9606-9608 DT denotes an
T8361 9604-9605 , denotes ,
T8360 9599-9604 NN denotes probe
T8359 9595-9598 DT denotes the
T8358 9592-9594 TO denotes to
T8357 9586-9591 VBZ denotes binds
T8356 9579-9585 PRP denotes itself
T8355 9575-9578 NN denotes tag
T8354 9569-9574 JJ denotes c-Myc
T8353 9565-9568 DT denotes the
T8352 9560-9564 IN denotes that
T8351 9548-9559 NN denotes possibility
T8350 9544-9547 DT denotes the
T8349 9540-9543 RP denotes out
T8348 9535-9539 VB denotes rule
T8347 9532-9534 TO denotes To
T8346 9530-9531 . denotes .
T8345 9517-9530 JJ denotes Sox6-specific
T8344 9514-9516 VBZ denotes is
T8343 9506-9513 JJ denotes binding
T8342 9502-9505 DT denotes the
T8341 9497-9501 IN denotes that
T8340 9486-9496 VBG denotes indicating
T8339 9484-9485 , denotes ,
T8338 9480-9484 NN denotes band
T8337 9476-9479 DT denotes the
T8336 9465-9475 VBP denotes supershift
T8335 9454-9464 NNS denotes antibodies
T8334 9449-9453 JJ denotes Sox6
T8333 9445-9448 CC denotes and
T8332 9439-9444 JJ denotes c-Myc
T8331 9434-9438 DT denotes both
T8330 9432-9433 , denotes ,
T8329 9424-9432 RB denotes Moreover
T8328 9422-9423 . denotes .
T8327 9415-9422 NN denotes protein
T8326 9410-9414 NNP denotes Sox6
T8325 9403-9409 VBN denotes tagged
T8324 9399-9402 DT denotes the
T8323 9396-9398 IN denotes by
T8322 9388-9395 VBN denotes shifted
T8321 9384-9387 VBD denotes was
T8320 9378-9383 NN denotes probe
T8319 9372-9377 JJ denotes 36-bp
T8318 9368-9371 DT denotes The
T8317 9366-9367 . denotes .
T8316 9365-9366 -RRB- denotes )
T8315 9363-9365 CD denotes 2C
T8314 9356-9362 NN denotes Figure
T8313 9355-9356 -LRB- denotes (
T8312 9343-9354 NNS denotes experiments
T8311 9334-9342 NN denotes analysis
T8310 9325-9333 NN denotes deletion
T8309 9321-9324 DT denotes the
T8308 9318-9320 IN denotes by
T8307 9310-9317 VBN denotes defined
T8306 9301-9309 NN denotes promoter
T8305 9298-9300 JJ denotes ɛy
T8304 9294-9297 DT denotes the
T8303 9287-9293 IN denotes within
T8302 9285-9286 -RRB- denotes )
T8301 9283-9285 NN denotes 3B
T8300 9276-9282 NN denotes Figure
T8299 9275-9276 -LRB- denotes (
T8298 9268-9274 NN denotes region
T8297 9262-9267 JJ denotes 36-bp
T8296 9258-9261 DT denotes the
T8295 9253-9257 IN denotes with
T8294 9243-9252 JJ denotes associate
T8293 9232-9242 RB denotes physically
T8292 9229-9231 TO denotes to
T8291 9224-9228 JJ denotes able
T8290 9221-9223 VBZ denotes is
T8289 9216-9220 NNP denotes Sox6
T8288 9214-9215 . denotes .
T8287 9213-9214 -RRB- denotes )
T8286 9211-9213 NN denotes 3A
T8285 9204-9210 NN denotes Figure
T8284 9203-9204 -LRB- denotes (
T8283 9197-9202 NNS denotes sites
T8282 9189-9196 JJ denotes binding
T8281 9180-9188 NNP denotes Sox/Sox6
T8280 9177-9179 IN denotes in
T8279 9175-9176 -RRB- denotes )
T8278 9173-9175 CD denotes M3
T8277 9169-9172 CC denotes and
T8276 9166-9168 CD denotes M2
T8275 9165-9166 -LRB- denotes (
T8274 9157-9164 VBN denotes mutated
T8273 9154-9156 CC denotes or
T8272 9152-9153 , denotes ,
T8271 9151-9152 -RRB- denotes )
T8270 9149-9151 CD denotes M1
T8269 9148-9149 -LRB- denotes (
T8268 9138-9147 VBN denotes truncated
T8267 9131-9137 CC denotes either
T8266 9129-9130 , denotes ,
T8265 9126-9129 VBP denotes are
T8264 9121-9125 WDT denotes that
T8263 9114-9120 NNS denotes probes
T8262 9106-9113 VBN denotes mutated
T8261 9100-9105 CD denotes three
T8260 9096-9099 VBP denotes are
T8259 9091-9095 NNP denotes EMSA
T8258 9087-9090 PRP$ denotes our
T8257 9084-9086 IN denotes in
T8256 9075-9083 VBN denotes included
T8255 9070-9074 RB denotes Also
T8254 9068-9069 . denotes .
T8253 9063-9068 NNS denotes sites
T8252 9055-9062 JJ denotes binding
T8251 9046-9054 NNP denotes Sox/Sox6
T8250 9036-9045 NN denotes consensus
T8249 9032-9035 CD denotes two
T8248 9023-9031 VBZ denotes contains
T8247 9017-9022 NN denotes probe
T8246 9012-9016 DT denotes This
T8245 9010-9011 . denotes .
T8244 9002-9010 NNS denotes analyses
T8243 8993-9001 NN denotes deletion
T8242 8984-8992 NN denotes promoter
T8241 8980-8983 PRP$ denotes our
T8240 8977-8979 IN denotes in
T8239 8969-8976 VBN denotes defined
T8238 8960-8968 NN denotes promoter
T8237 8957-8959 JJ denotes ɛy
T8236 8953-8956 DT denotes the
T8235 8950-8952 IN denotes of
T8234 8943-8949 NN denotes region
T8233 8934-8942 JJ denotes critical
T8232 8930-8933 DT denotes the
T8231 8927-8929 TO denotes to
T8230 8915-8926 NNS denotes corresponds
T8229 8909-8914 NN denotes probe
T8228 8906-8908 NN denotes WT
T8227 8904-8905 -RRB- denotes )
T8226 8902-8904 NN denotes bp
T8225 8901-8902 -LRB- denotes (
T8224 8896-8900 NN denotes pair
T8223 8891-8895 NN denotes base
T8222 8888-8890 CD denotes 36
T8485 10197-10202 NN denotes probe
T8484 10190-10196 JJ denotes mutant
T8483 10187-10189 NNP denotes M2
T8482 10183-10186 DT denotes The
T8481 10181-10182 . denotes .
T8480 10180-10181 -RRB- denotes )
T8479 10178-10180 NNP denotes 3E
T8478 10171-10177 NNP denotes Figure
T8477 10170-10171 -LRB- denotes (
T8476 10165-10169 NNP denotes EMSA
T8475 10162-10164 IN denotes in
T8474 10154-10161 VB denotes compete
T8473 10151-10153 TO denotes to
T8472 10143-10150 NN denotes ability
T8471 10137-10142 PRP$ denotes their
T8470 10129-10136 VBP denotes abolish
T8469 10127-10128 -RRB- denotes )
T8468 10125-10127 CD denotes M3
T8467 10121-10124 CC denotes and
T8466 10118-10120 CD denotes M1
T8465 10117-10118 -LRB- denotes (
T8464 10111-10116 NNS denotes sites
T8463 10103-10110 JJ denotes binding
T8462 10094-10102 NNP denotes Sox/Sox6
T8461 10085-10093 JJ denotes putative
T8460 10082-10084 IN denotes of
T8459 10073-10081 NNP denotes Ablation
T8458 10071-10072 . denotes .
T8457 10070-10071 -RRB- denotes )
T8456 10068-10070 CD denotes 3E
T8455 10061-10067 NN denotes Figure
T8454 10060-10061 -LRB- denotes (
T8453 10054-10059 NN denotes assay
T8452 10042-10053 NN denotes competition
T8451 10038-10041 DT denotes the
T8450 10035-10037 IN denotes in
T8449 10029-10034 VBN denotes shown
T8448 10026-10028 IN denotes as
T8447 10024-10025 , denotes ,
T8446 10017-10024 JJ denotes binding
T8445 10013-10016 DT denotes the
T8444 10009-10012 IN denotes for
T8443 10000-10008 VBN denotes required
T8442 9996-9999 VBP denotes are
T8441 9990-9995 NN denotes probe
T8440 9986-9989 NNP denotes DNA
T8439 9982-9985 DT denotes the
T8438 9979-9981 IN denotes of
T8437 9973-9978 NNS denotes sites
T8436 9965-9972 JJ denotes binding
T8435 9956-9964 NNP denotes Sox/Sox6
T8434 9946-9955 NN denotes consensus
T8433 9939-9945 JJ denotes intact
T8432 9935-9938 DT denotes The
T8431 9933-9934 . denotes .
T8430 9932-9933 -RRB- denotes )
T8429 9930-9932 CD denotes 3D
T8428 9923-9929 NN denotes Figure
T8427 9922-9923 -LRB- denotes (
T8426 9916-9921 NNS denotes cells
T8425 9912-9915 NNP denotes MEL
T8424 9909-9911 IN denotes in
T8423 9900-9908 NN denotes sequence
T8422 9896-9899 NN denotes DNA
T8421 9891-9895 DT denotes this
T8420 9888-9890 TO denotes to
T8419 9882-9887 VBZ denotes binds
T8418 9873-9881 RB denotes directly
T8417 9868-9872 JJ denotes Sox6
T8416 9866-9867 . denotes .
T8415 9865-9866 NNP denotes ]
T8414 9863-9865 CD denotes 33
T8413 9862-9863 NNP denotes [
T8412 9859-9861 VB denotes ɛy
T6763 5815-5816 . denotes .
T6762 5814-5815 -RRB- denotes )
T6761 5812-5814 NNP denotes 3A
T6760 5805-5811 NNP denotes Figure
T6759 5804-5805 -LRB- denotes (
T6758 5802-5803 NNP denotes ]
T6757 5801-5802 CD denotes 5
T6756 5800-5801 VBP denotes [
T6755 5794-5799 NNS denotes sites
T6754 5786-5793 JJ denotes binding
T6753 5776-5785 NN denotes consensus
T6752 5767-5775 JJ denotes Sox/Sox6
T6751 5763-5766 CD denotes two
T6750 5755-5762 VBZ denotes reveals
T6749 5748-5754 NN denotes region
T6748 5742-5747 JJ denotes short
T6747 5737-5741 DT denotes this
T6746 5734-5736 IN denotes of
T6745 5725-5733 NN denotes Analysis
T6744 5723-5724 . denotes .
T6743 5713-5723 NN denotes repression
T6742 5708-5712 JJ denotes Sox6
T6741 5704-5707 IN denotes for
T6740 5695-5703 JJ denotes critical
T6739 5692-5694 VBZ denotes is
T6738 5687-5691 WDT denotes that
T6737 5678-5686 NN denotes promoter
T6736 5669-5677 JJ denotes proximal
T6735 5666-5668 JJ denotes ɛy
T6734 5662-5665 DT denotes the
T6733 5655-5661 IN denotes within
T6732 5653-5654 -RRB- denotes )
T6731 5651-5653 CD denotes 37
T6730 5650-5651 CD denotes −
T6729 5647-5649 TO denotes to
T6728 5644-5646 CD denotes 63
T6727 5643-5644 FW denotes −
T6726 5642-5643 -LRB- denotes (
T6725 5635-5641 NN denotes region
T6724 5633-5634 DT denotes a
T6723 5625-5632 VBD denotes defined
T6722 5623-5624 , denotes ,
T6721 5621-5623 CD denotes 2C
T6720 5614-5620 NN denotes Figure
T6719 5611-5613 IN denotes in
T6718 5605-5610 VBN denotes shown
T6717 5602-5604 IN denotes as
T6716 5600-5601 , denotes ,
T6715 5592-5600 NN denotes promoter
T6714 5589-5591 JJ denotes ɛy
T6713 5585-5588 DT denotes the
T6712 5582-5584 IN denotes of
T6711 5573-5581 NN denotes analysis
T6710 5564-5572 NN denotes Deletion
T6709 5562-5563 . denotes .
T6708 5556-5562 NN denotes manner
T6707 5538-5555 JJ denotes CtBP2-independent
T6706 5536-5537 DT denotes a
T6705 5533-5535 IN denotes in
T6704 5524-5532 NN denotes promoter
T6703 5521-5523 JJ denotes ɛy
T6702 5517-5520 DT denotes the
T6701 5507-5516 NNS denotes represses
T6700 5502-5506 JJ denotes Sox6
T6699 5497-5501 IN denotes that
T6698 5486-5496 VBG denotes indicating
T6697 5484-5485 , denotes ,
T6696 5483-5484 -RRB- denotes )
T6695 5481-5483 NN denotes 2B
T6694 5474-5480 NN denotes Figure
T6693 5473-5474 -LRB- denotes (
T6692 5467-5472 NN denotes assay
T6691 5454-5466 NN denotes transfection
T6690 5450-5453 DT denotes the
T6689 5447-5449 IN denotes in
T6688 5438-5446 NN denotes promoter
T6687 5435-5437 JJ denotes ɛy
T6686 5431-5434 DT denotes the
T6685 5423-5430 VB denotes repress
T6684 5420-5422 TO denotes to
T6683 5412-5419 NN denotes ability
T6682 5408-5411 DT denotes the
T6681 5400-5407 VBZ denotes retains
T6680 5395-5399 JJ denotes Sox6
T6679 5392-5394 IN denotes of
T6678 5384-5391 NN denotes version
T6677 5377-5383 JJ denotes mutant
T6676 5372-5376 DT denotes this
T6675 5370-5371 , denotes ,
T6674 5363-5370 RB denotes However
T6673 5361-5362 . denotes .
T6672 5355-5361 NN denotes domain
T6671 5347-5354 JJ denotes binding
T6670 5343-5346 NNP denotes DNA
T6669 5339-5342 NNP denotes HMG
T6668 5335-5338 DT denotes the
T6667 5332-5334 IN denotes in
T6666 5328-5331 RB denotes not
T6665 5325-5327 VBZ denotes is
T6664 5318-5324 NN denotes change
T6663 5313-5317 NN denotes acid
T6662 5307-5312 JJ denotes amino
T6661 5302-5306 DT denotes This
T6660 5300-5301 . denotes .
T6659 5299-5300 NNP denotes ]
T6658 5298-5299 CD denotes 5
T6657 5297-5298 NN denotes [
T6656 5285-5296 NN denotes interaction
T6655 5274-5284 JJ denotes Sox6-CtBP2
T6654 5266-5273 VB denotes abolish
T6653 5263-5265 TO denotes to
T6652 5252-5262 JJ denotes sufficient
T6651 5249-5251 VB denotes be
T6650 5246-5248 TO denotes to
T6649 5237-5245 VBN denotes reported
T6648 5226-5236 RB denotes previously
T6647 5221-5225 VBN denotes been
T6646 5217-5220 VBZ denotes has
T6645 5212-5216 WDT denotes that
T6644 5204-5211 NN denotes protein
T6643 5199-5203 JJ denotes Sox6
T6642 5195-5198 DT denotes the
T6641 5192-5194 IN denotes in
T6640 5190-5191 -RRB- denotes )
T6639 5185-5190 NNP denotes L386H
T6638 5184-5185 -LRB- denotes (
T6637 5175-5183 NN denotes mutation
T6636 5169-5174 NN denotes point
T6635 5167-5168 DT denotes a
T6634 5156-5166 VBD denotes introduced
T6633 5153-5155 PRP denotes we
T6632 5151-5152 , denotes ,
T6631 5143-5151 NN denotes promoter
T6630 5140-5142 JJ denotes ɛy
T6629 5136-5139 DT denotes the
T6628 5133-5135 IN denotes of
T6627 5122-5132 NN denotes repression
T6626 5117-5121 JJ denotes Sox6
T6625 5113-5116 IN denotes for
T6624 5104-5112 VBN denotes required
T6623 5101-5103 VBZ denotes is
T6622 5095-5100 NNP denotes CtBP2
T6621 5090-5094 IN denotes with
T6620 5078-5089 NN denotes interaction
T6619 5074-5077 DT denotes the
T6618 5066-5073 IN denotes whether
T6617 5054-5065 VB denotes investigate
T6616 5051-5053 TO denotes To
T6615 5049-5050 . denotes .
T6614 5048-5049 -RRB- denotes )
T6613 5044-5048 NNS denotes data
T6612 5032-5043 JJ denotes unpublished
T6611 5031-5032 -LRB- denotes (
T6610 5025-5030 NNS denotes cells
T6609 5019-5024 NNP denotes GM979
T6608 5016-5018 IN denotes in
T6607 5006-5015 VBN denotes expressed
T6606 5003-5005 VBZ denotes is
T6605 4997-5002 NNP denotes CtBP2
T6604 4995-4996 . denotes .
T6603 4994-4995 NNP denotes ]
T6602 4993-4994 CD denotes 5
T6601 4992-4993 NN denotes [
T6600 4983-4991 NN denotes promoter
T6599 4977-4982 JJ denotes fgf-3
T6598 4973-4976 DT denotes the
T6597 4970-4972 IN denotes on
T6596 4968-4969 , denotes ,
T6595 4963-4968 NNP denotes CtBP2
T6594 4961-4962 , denotes ,
T6593 4949-4961 NN denotes co-repressor
T6592 4939-4948 VBN denotes expressed
T6591 4932-4938 RB denotes widely
T6590 4930-4931 DT denotes a
T6589 4925-4929 IN denotes with
T6588 4916-4924 VB denotes interact
T6587 4913-4915 TO denotes to
T6586 4909-4912 CC denotes and
T6585 4899-4908 NN denotes repressor
T6584 4897-4898 DT denotes a
T6583 4894-4896 IN denotes as
T6582 4890-4893 VB denotes act
T6581 4887-4889 TO denotes to
T6580 4881-4886 VBN denotes shown
T6579 4876-4880 VBN denotes been
T6578 4872-4875 VBZ denotes has
T6577 4867-4871 NNP denotes Sox6
T6576 3484-3485 . denotes .
T6575 3479-3484 NN denotes level
T6574 3463-3478 JJ denotes transcriptional
T6573 3459-3462 DT denotes the
T6572 3456-3458 IN denotes at
T6571 3447-3455 NN denotes promoter
T6570 3444-3446 JJ denotes ɛy
T6569 3440-3443 DT denotes the
T6447 2835-2836 . denotes .
T6446 2834-2835 NNP denotes ]
T6445 2832-2834 CD denotes 30
T6444 2831-2832 NNP denotes [
T6443 2823-2830 NNS denotes globins
T6442 2818-2822 JJ denotes beta
T6441 2812-2817 NN denotes adult
T6440 2808-2811 CC denotes and
T6439 2805-2807 NN denotes ɛy
T6438 2800-2804 DT denotes both
T6437 2790-2799 VBZ denotes expresses
T6436 2785-2789 WDT denotes that
T6435 2780-2784 NN denotes line
T6434 2775-2779 NN denotes cell
T6433 2759-2774 JJ denotes erythroleukemic
T6432 2752-2758 JJ denotes murine
T6431 2750-2751 DT denotes a
T6430 2748-2749 , denotes ,
T6429 2743-2748 NNS denotes cells
T6428 2737-2742 NNP denotes GM979
T6427 2733-2736 CC denotes and
T6426 2727-2732 NN denotes assay
T6425 2714-2726 NN denotes transfection
T6424 2704-2713 NN denotes transient
T6423 2698-2703 NN denotes vitro
T6422 2695-2697 IN denotes in
T6421 2692-2694 DT denotes an
T6420 2687-2691 VBD denotes used
T6419 2684-2686 PRP denotes we
T6418 2682-2683 , denotes ,
T6417 2677-2682 NN denotes level
T6416 2661-2676 JJ denotes transcriptional
T6415 2657-2660 DT denotes the
T6414 2654-2656 IN denotes at
T6413 2645-2653 NN denotes promoter
T6412 2640-2644 NN denotes gene
T6411 2637-2639 JJ denotes ɛy
T6410 2633-2636 DT denotes the
T6409 2630-2632 IN denotes on
T6408 2625-2629 VBZ denotes acts
T6407 2616-2624 RB denotes directly
T6406 2611-2615 JJ denotes Sox6
T6405 2603-2610 IN denotes whether
T6404 2591-2602 VB denotes investigate
T6403 2588-2590 TO denotes To
T6402 2586-2587 . denotes .
T6401 2578-2586 NN denotes promoter
T6400 2575-2577 JJ denotes ɛy
T6399 2571-2574 DT denotes the
T6398 2568-2570 IN denotes of
T6397 2559-2567 NN denotes activity
T6396 2543-2558 JJ denotes transcriptional
T6395 2539-2542 RB denotes not
T6394 2537-2538 , denotes ,
T6393 2533-2537 NNP denotes mRNA
T6392 2530-2532 JJ denotes ɛy
T6391 2527-2529 IN denotes of
T6390 2520-2526 NNS denotes levels
T6389 2507-2519 JJ denotes steady-state
T6388 2499-2506 NN denotes measure
T6387 2497-2498 -RRB- denotes )
T6386 2496-2497 CD denotes 1
T6385 2489-2495 NN denotes Figure
T6384 2488-2489 -LRB- denotes (
T6383 2481-2487 NNS denotes assays
T6382 2477-2480 NNP denotes PCR
T6381 2467-2476 JJ denotes Real-time
T6380 2461-2466 NNP denotes Level
T6379 2445-2460 NNP denotes Transcriptional
T6378 2441-2444 DT denotes the
T6377 2438-2440 IN denotes at
T6376 2429-2437 NNP denotes Promoter
T6375 2424-2428 NNP denotes Gene
T6374 2421-2423 NN denotes ɛy
T6373 2417-2420 DT denotes the
T6372 2407-2416 NNPS denotes Represses
T6371 2398-2406 RB denotes Directly
T6370 2393-2397 NNP denotes Sox6
T6369 2388-2392 WDT denotes That
T6368 2379-2387 NNP denotes Indicate
T6367 2373-2378 NNP denotes Cells
T6366 2367-2372 NNP denotes GM979
T6365 2361-2366 VBG denotes Using
T6364 2353-2360 NNP denotes Studies
T6363 2340-2352 NNP denotes Transfection
T6568 3432-3439 VB denotes repress
T6567 3429-3431 TO denotes to
T6566 3424-3428 NNS denotes acts
T6565 3419-3423 JJ denotes Sox6
T6564 3414-3418 IN denotes that
T6563 3405-3413 VBP denotes indicate
T6562 3400-3404 NNS denotes data
T6561 3394-3399 DT denotes These
T6560 3392-3393 . denotes .
T6559 3391-3392 -RRB- denotes )
T6558 3389-3391 NN denotes 2B
T6557 3382-3388 NN denotes Figure
T6556 3381-3382 -LRB- denotes (
T6555 3372-3380 NN denotes activity
T6554 3366-3371 JJ denotes E-Luc
T6553 3358-3365 VB denotes repress
T6552 3355-3357 TO denotes to
T6551 3349-3354 VBZ denotes fails
T6550 3347-3348 -RRB- denotes )
T6549 3341-3347 NN denotes allele
T6548 3335-3340 NN denotes mouse
T6547 3328-3334 JJ denotes p 100H
T6546 3324-3327 DT denotes the
T6545 3321-3323 TO denotes to
T6544 3313-3320 JJ denotes similar
T6543 3312-3313 -LRB- denotes (
T6542 3310-3311 NNP denotes ]
T6541 3308-3310 CD denotes 32
T6540 3307-3308 NNP denotes [
T6539 3300-3306 NN denotes domain
T6538 3296-3299 NNP denotes HMG
T6537 3292-3295 PRP$ denotes its
T6536 3286-3291 VBZ denotes lacks
T6535 3281-3285 WDT denotes that
T6534 3273-3280 NN denotes protein
T6533 3268-3272 NNP denotes Sox6
T6532 3258-3267 VBN denotes truncated
T6531 3256-3257 DT denotes a
T6530 3253-3255 IN denotes of
T6529 3238-3252 NN denotes overexpression
T6528 3236-3237 , denotes ,
T6527 3228-3236 NN denotes contrast
T6526 3225-3227 IN denotes In
T6525 3223-3224 . denotes .
T6524 3222-3223 -RRB- denotes )
T6523 3220-3222 NN denotes 2B
T6522 3213-3219 NN denotes Figure
T6521 3212-3213 -LRB- denotes (
T6520 3203-3211 NN denotes activity
T6519 3194-3202 NN denotes reporter
T6518 3188-3193 JJ denotes E-Luc
T6517 3185-3187 IN denotes of
T6516 3174-3184 NN denotes repression
T6515 3157-3173 JJ denotes dosage-dependent
T6514 3155-3156 DT denotes a
T6513 3152-3154 TO denotes to
T6512 3146-3151 VBZ denotes leads
T6511 3133-3145 NN denotes transfection
T6510 3123-3132 JJ denotes transient
T6509 3120-3122 IN denotes by
T6508 3114-3119 NNS denotes cells
T6507 3108-3113 NNP denotes GM979
T6506 3105-3107 IN denotes in
T6505 3100-3104 NNP denotes Sox6
T6504 3097-3099 IN denotes of
T6503 3082-3096 NNP denotes Overexpression
T6502 3080-3081 . denotes .
T6501 3079-3080 -RRB- denotes )
T6500 3072-3079 NNPS denotes Methods
T6499 3068-3071 CC denotes and
T6498 3058-3067 NNPS denotes Materials
T6497 3055-3057 IN denotes in
T6496 3046-3054 VBN denotes detailed
T6495 3045-3046 -LRB- denotes (
T6494 3042-3044 CD denotes 2A
T6493 3035-3041 NN denotes Figure
T6492 3032-3034 IN denotes in
T6491 3026-3031 VBN denotes shown
T6490 3023-3025 IN denotes as
T6489 3021-3022 , denotes ,
T6488 3017-3021 NN denotes gene
T6487 3008-3016 NN denotes reporter
T6486 2997-3007 NN denotes luciferase
T6485 2993-2996 DT denotes the
T6484 2990-2992 IN denotes by
T6483 2981-2989 VBN denotes followed
T6482 2979-2980 , denotes ,
T6481 2978-2979 -RRB- denotes )
T6480 2976-2978 NN denotes kb
T6479 2972-2975 CD denotes 2.2
T6478 2971-2972 -LRB- denotes (
T6477 2962-2970 NN denotes promoter
T6476 2953-2961 JJ denotes proximal
T6475 2950-2952 JJ denotes ɛy
T6474 2946-2949 DT denotes the
T6473 2943-2945 TO denotes to
T6472 2941-2942 NNP denotes ]
T6471 2939-2941 CD denotes 31
T6470 2938-2939 NNP denotes [
T6469 2936-2937 -RRB- denotes )
T6468 2934-2936 NN denotes kb
T6467 2930-2933 CD denotes 2.5
T6466 2929-2930 -LRB- denotes (
T6465 2921-2928 NN denotes element
T6464 2919-2920 -RRB- denotes )
T6463 2915-2919 NNP denotes μLCR
T6462 2914-2915 -LRB- denotes (
T6461 2904-2913 NN denotes micro-LCR
T6460 2902-2903 DT denotes a
T6459 2895-2901 NN denotes fusing
T6458 2892-2894 IN denotes by
T6457 2890-2891 -RRB- denotes )
T6456 2885-2890 JJ denotes E-Luc
T6455 2884-2885 -LRB- denotes (
T6454 2874-2883 VBP denotes construct
T6453 2865-2873 NN denotes reporter
T6452 2856-2864 NN denotes promoter
T6451 2853-2855 JJ denotes ɛy
T6450 2850-2852 DT denotes an
T6449 2840-2849 VBD denotes generated
T6448 2837-2839 PRP denotes We
T5325 1925-1926 . denotes .
T5324 1921-1925 NNS denotes mice
T5323 1918-1920 NNP denotes WT
T5322 1907-1917 JJ denotes homozygous
T5321 1903-1906 NN denotes dpc
T5320 1898-1902 CD denotes 18.5
T5319 1894-1897 CC denotes and
T5318 1890-1893 NN denotes dpc
T5317 1885-1889 CD denotes 15.5
T5316 1882-1884 IN denotes of
T5315 1875-1881 NNS denotes livers
T5314 1871-1874 DT denotes the
T5313 1868-1870 IN denotes in
T5312 1857-1867 NN denotes expression
T5311 1853-1856 NN denotes min
T5310 1852-1853 NN denotes /
T5309 1848-1852 NN denotes βmaj
T5308 1845-1847 IN denotes of
T5307 1839-1844 NN denotes level
T5306 1835-1838 DT denotes the
T5305 1832-1834 TO denotes to
T5304 1821-1831 JJ denotes equivalent
T5303 1807-1820 RB denotes statistically
T5302 1804-1806 VBZ denotes is
T5301 1799-1803 NNS denotes mice
T5300 1792-1798 JJ denotes mutant
T5299 1781-1791 JJ denotes homozygous
T5298 1777-1780 NN denotes dpc
T5297 1772-1776 CD denotes 18.5
T5296 1768-1771 CC denotes and
T5295 1764-1767 NN denotes dpc
T5294 1759-1763 CD denotes 15.5
T5293 1756-1758 IN denotes of
T5292 1749-1755 NNS denotes livers
T5291 1745-1748 DT denotes the
T5290 1742-1744 IN denotes in
T5289 1731-1741 NN denotes expression
T5288 1728-1730 JJ denotes ɛy
T5287 1725-1727 IN denotes of
T5286 1719-1724 NN denotes level
T5285 1715-1718 DT denotes the
T5284 1710-1714 IN denotes that
T5283 1705-1709 VBP denotes note
T5282 1702-1704 PRP denotes We
T5281 1700-1701 . denotes .
T5280 1699-1700 NNP denotes ]
T5279 1697-1699 CD denotes 29
T5278 1696-1697 NNP denotes [
T5277 1691-1695 NNS denotes mice
T5276 1685-1690 JJ denotes fetal
T5275 1682-1684 NNP denotes WT
T5274 1678-1681 IN denotes for
T5273 1670-1677 NNS denotes results
T5272 1660-1669 VBN denotes published
T5271 1649-1659 RB denotes previously
T5270 1644-1648 IN denotes with
T5269 1634-1643 NN denotes agreement
T5268 1631-1633 IN denotes in
T5267 1627-1630 VBP denotes are
T5266 1623-1626 CC denotes and
T5265 1615-1622 NNS denotes samples
T5264 1611-1614 DT denotes all
T5263 1604-1610 IN denotes across
T5262 1593-1603 JJ denotes comparable
T5261 1588-1592 RB denotes thus
T5260 1584-1587 VBP denotes are
T5259 1580-1583 CC denotes and
T5258 1573-1579 NNS denotes levels
T5257 1564-1572 JJ denotes relative
T5256 1560-1563 VBP denotes are
T5255 1554-1559 VBN denotes shown
T5254 1547-1553 NNS denotes levels
T5253 1543-1546 DT denotes the
T5252 1541-1542 , denotes ,
T5251 1534-1541 NN denotes control
T5250 1525-1533 JJ denotes internal
T5249 1520-1524 JJ denotes same
T5248 1516-1519 DT denotes the
T5247 1511-1515 IN denotes with
T5246 1506-1510 NN denotes time
T5245 1501-1505 JJ denotes same
T5244 1497-1500 DT denotes the
T5243 1494-1496 IN denotes at
T5242 1484-1493 VBN denotes performed
T5241 1479-1483 VBD denotes were
T5240 1472-1478 NNS denotes assays
T5239 1468-1471 DT denotes the
T5238 1465-1467 IN denotes of
T5237 1461-1464 DT denotes all
T5236 1453-1460 IN denotes Because
T5235 1451-1452 . denotes .
T5234 1450-1451 -RRB- denotes )
T5233 1446-1450 NNS denotes bars
T5232 1440-1445 NN denotes error
T5231 1437-1439 IN denotes by
T5230 1431-1436 VBN denotes shown
T5229 1428-1430 VBZ denotes is
T5228 1423-1427 NN denotes data
T5227 1419-1422 DT denotes the
T5226 1416-1418 IN denotes of
T5225 1406-1415 NN denotes deviation
T5224 1397-1405 JJ denotes standard
T5223 1396-1397 -LRB- denotes (
T5222 1385-1395 NN denotes triplicate
T5221 1382-1384 IN denotes in
T5220 1372-1381 VBN denotes performed
T5219 1367-1371 VBD denotes were
T5218 1362-1366 WDT denotes that
T5217 1354-1361 NNS denotes results
T5216 1350-1353 NNP denotes PCR
T5215 1345-1349 NN denotes time
T5214 1340-1344 JJ denotes real
T5213 1329-1339 VBP denotes illustrate
T5212 1327-1328 CD denotes 1
T5211 1320-1326 NN denotes Figure
T5210 1317-1319 IN denotes in
T5209 1310-1316 NNS denotes graphs
T5208 1306-1309 DT denotes The
T5207 1304-1305 . denotes .
T5206 1294-1304 NN denotes expression
T5205 1287-1293 NN denotes globin
T5204 1277-1286 JJ denotes postnatal
T5203 1266-1276 VBG denotes evaluating
T5202 1261-1265 IN denotes from
T5201 1258-1260 PRP denotes us
T5200 1248-1257 VBZ denotes precludes
T5199 1246-1247 -RRB- denotes )
T5198 1245-1246 NNP denotes ]
T5197 1243-1245 CD denotes 14
T5196 1242-1243 NNP denotes [
T5195 1235-1241 NN denotes defect
T5194 1229-1234 NN denotes heart
T5193 1225-1228 DT denotes the
T5192 1220-1224 IN denotes from
T5191 1209-1219 RB denotes presumably
T5190 1208-1209 -LRB- denotes (
T5189 1203-1207 NNS denotes mice
T5188 1196-1202 JJ denotes mutant
T5187 1193-1195 IN denotes of
T5186 1183-1192 NN denotes lethality
T5185 1173-1182 JJ denotes Perinatal
T5184 1171-1172 . denotes .
T5183 1170-1171 -RRB- denotes )
T5182 1169-1170 CD denotes 1
T5181 1162-1168 NN denotes Figure
T5180 1161-1162 -LRB- denotes (
T5179 1157-1160 NN denotes dpc
T5178 1152-1156 CD denotes 18.5
T5177 1149-1151 IN denotes at
T5176 1144-1148 NNS denotes mice
T5175 1141-1143 NNP denotes WT
T5174 1138-1140 IN denotes in
T5173 1133-1137 IN denotes than
T5172 1128-1132 NNS denotes mice
T5171 1117-1127 JJ denotes homozygous
T5170 1111-1116 JJ denotes p100H
T5169 1108-1110 IN denotes in
T5168 1101-1107 JJR denotes higher
T5167 1092-1100 RB denotes somewhat
T5166 1087-1091 RB denotes also
T5165 1084-1086 VBZ denotes is
T5164 1077-1083 NN denotes globin
T5163 1075-1076 NN denotes β
T5162 1069-1074 NN denotes adult
T5161 1066-1068 IN denotes of
T5160 1060-1065 NN denotes level
T5159 1049-1059 NN denotes expression
T5158 1045-1048 DT denotes the
T5157 1043-1044 , denotes ,
T5156 1035-1043 RB denotes Moreover
T5155 1033-1034 . denotes .
T5154 1032-1033 -RRB- denotes )
T5153 1031-1032 CD denotes 1
T5152 1024-1030 NN denotes Figure
T5151 1023-1024 -LRB- denotes (
T5150 1019-1022 NN denotes dpc
T5149 1014-1018 CD denotes 18.5
T5148 1011-1013 IN denotes at
T5147 1004-1010 NN denotes globin
T5146 1001-1003 JJ denotes ɛy
T5145 997-1000 IN denotes for
T5144 992-996 VBN denotes seen
T5143 987-991 IN denotes than
T5142 980-986 NN denotes extent
T5141 973-979 JJR denotes lesser
T5140 968-972 JJ denotes much
T5139 966-967 DT denotes a
T5138 963-965 TO denotes to
T5137 959-962 CC denotes but
T5136 957-958 , denotes ,
T5135 953-957 NNS denotes mice
T5134 950-952 NNP denotes WT
T5133 945-949 IN denotes with
T5132 936-944 VBN denotes compared
T5131 934-935 , denotes ,
T5130 930-934 NNS denotes mice
T5129 919-929 JJ denotes homozygous
T5128 913-918 JJ denotes p100H
T5127 910-912 IN denotes in
T5126 903-909 JJR denotes higher
T5125 898-902 RB denotes also
T5124 894-897 VBP denotes are
T5123 892-893 -RRB- denotes )
T5122 889-892 CD denotes βh1
T5121 885-888 CC denotes and
T5120 883-884 NN denotes ζ
T5119 882-883 -LRB- denotes (
T5118 876-881 NNS denotes genes
T5117 869-875 NN denotes globin
T5116 859-868 JJ denotes embryonic
T5115 855-858 CD denotes two
T5114 849-854 JJ denotes other
T5113 845-848 DT denotes the
T5112 842-844 IN denotes of
T5111 835-841 NNS denotes levels
T5110 824-834 NN denotes expression
T5109 820-823 DT denotes the
T5108 818-819 , denotes ,
T5107 805-818 RB denotes Interestingly
T5106 803-804 . denotes .
T5105 802-803 -RRB- denotes )
T5104 798-802 NNS denotes data
T5103 786-797 JJ denotes unpublished
T5102 785-786 -LRB- denotes (
T5101 780-784 NNS denotes mice
T5100 767-779 JJ denotes heterozygous
T5099 763-766 CC denotes and
T5098 760-762 NNP denotes WT
T5097 752-759 IN denotes between
T5096 747-751 VBN denotes seen
T5095 743-746 VBD denotes was
T5094 732-742 NN denotes difference
T5093 729-731 DT denotes No
T5092 727-728 . denotes .
T5091 723-727 NNS denotes mice
T5090 720-722 NNP denotes WT
T5089 717-719 IN denotes in
T5088 708-716 VBN denotes observed
T5087 697-707 NN denotes expression
T5086 694-696 IN denotes in
T5085 686-693 NN denotes decline
T5084 682-685 DT denotes the
T5083 679-681 TO denotes to
T5082 670-678 NN denotes contrast
T5081 667-669 IN denotes in
T5080 665-666 , denotes ,
T5079 661-665 NNS denotes mice
T5078 654-660 JJ denotes mutant
T5077 651-653 IN denotes in
T5076 644-650 NNS denotes points
T5075 639-643 NN denotes time
T5074 634-638 DT denotes both
T5073 631-633 IN denotes at
T5072 624-630 NNS denotes levels
T5071 619-623 JJ denotes high
T5070 616-618 IN denotes at
T5069 606-615 VBN denotes expressed
T5068 603-605 VBZ denotes is
T5067 598-602 NN denotes gene
T5066 595-597 JJ denotes ɛy
T5065 591-594 DT denotes the
T5064 589-590 , denotes ,
T5063 588-589 CD denotes 1
T5062 581-587 NN denotes Figure
T5061 578-580 IN denotes in
T5060 572-577 VBN denotes shown
T5059 569-571 IN denotes As
T5058 567-568 . denotes .
T5057 564-567 NN denotes dpc
T5056 559-563 CD denotes 18.5
T5055 555-558 CC denotes and
T5054 551-554 NN denotes dpc
T5053 546-550 CD denotes 15.5
T5052 544-545 , denotes ,
T5051 538-544 NNS denotes stages
T5050 524-537 JJ denotes developmental
T5049 520-523 CD denotes two
T5048 517-519 IN denotes at
T5047 510-516 NNS denotes livers
T5046 504-509 NN denotes mouse
T5045 501-503 NNP denotes WT
T5044 497-500 CC denotes and
T5043 490-496 JJ denotes mutant
T5042 484-489 JJ denotes p100H
T5041 481-483 IN denotes in
T5040 475-480 NNS denotes genes
T5039 468-474 NN denotes globin
T5038 462-467 JJ denotes other
T5037 459-461 IN denotes of
T5036 452-458 NNS denotes levels
T5035 441-451 NN denotes expression
T5034 437-440 DT denotes the
T5033 426-436 VB denotes quantitate
T5032 423-425 TO denotes to
T5031 418-422 VBN denotes used
T5030 414-417 VBD denotes was
T5029 410-413 NNP denotes PCR
T5028 400-409 JJ denotes Real-time
T5027 398-399 . denotes .
T5026 397-398 -RRB- denotes )
T5025 393-397 NNS denotes data
T5024 381-392 JJ denotes unpublished
T5023 380-381 -LRB- denotes (
T5022 378-379 -RRB- denotes )
T5021 375-378 NNP denotes PCR
T5020 374-375 -LRB- denotes (
T5019 365-373 NN denotes reaction
T5018 359-364 NN denotes chain
T5017 348-358 NN denotes polymerase
T5016 338-347 JJ denotes real-time
T5015 332-337 VBG denotes using
T5014 330-331 NNP denotes ]
T5013 328-330 CD denotes 13
T5012 327-328 NNP denotes [
T5011 322-326 NNP denotes Sox6
T5010 319-321 IN denotes of
T5009 312-318 NN denotes allele
T5008 302-311 JJ denotes knock-out
T5007 290-301 JJ denotes independent
T5006 287-289 DT denotes an
T5005 284-286 IN denotes in
T5004 274-283 VBN denotes confirmed
T5003 270-273 VBD denotes was
T5002 258-269 NN denotes observation
T5001 250-257 JJ denotes initial
T5000 245-249 DT denotes This
T4999 243-244 . denotes .
T4998 236-243 NNS denotes targets
T4997 225-235 JJ denotes downstream
T4996 220-224 JJ denotes Sox6
T4995 211-219 VB denotes identify
T4994 208-210 TO denotes to
T4993 194-207 NN denotes hybridization
T4992 182-193 JJ denotes subtractive
T4991 176-181 VBG denotes using
T4990 170-175 NN denotes mouse
T4989 163-169 JJ denotes p 100H
T4988 159-162 DT denotes the
T4987 156-158 IN denotes in
T4986 145-155 NN denotes transcript
T4985 133-144 JJ denotes upregulated
T4984 130-132 DT denotes an
T4983 127-129 IN denotes as
T4982 116-126 VBN denotes identified
T4981 106-115 RB denotes initially
T4980 102-105 VBD denotes was
T4979 97-101 NN denotes gene
T4978 90-96 NN denotes globin
T4977 87-89 JJ denotes ɛy
T4976 83-86 DT denotes The
T4975 78-82 NNP denotes Mice
T4974 63-77 JJ denotes Sox6-Deficient
T4973 60-62 IN denotes in
T4972 58-59 , denotes ,
T4971 56-58 NN denotes ɛy
T4970 54-55 , denotes ,
T4969 48-54 NNP denotes Globin
T4968 38-47 NNP denotes Embryonic
T4967 34-37 DT denotes the
T4966 31-33 IN denotes of
T4965 20-30 NN denotes Expression
T4964 9-19 JJ denotes Persistent
R3495 T4964 T4965 amod Persistent,Expression
R3496 T4965 T4965 ROOT Expression,Expression
R3497 T4966 T4965 prep of,Expression
R3498 T4967 T4969 det the,Globin
R3499 T4968 T4969 compound Embryonic,Globin
R3500 T4969 T4966 pobj Globin,of
R3501 T4970 T4969 punct ",",Globin
R3502 T4971 T4965 intj ɛy,Expression
R3503 T4972 T4965 punct ",",Expression
R3504 T4973 T4965 prep in,Expression
R3505 T4974 T4975 amod Sox6-Deficient,Mice
R3506 T4975 T4973 pobj Mice,in
R3507 T4976 T4979 det The,gene
R3508 T4977 T4979 amod ɛy,gene
R3509 T4978 T4979 compound globin,gene
R3510 T4979 T4982 nsubjpass gene,identified
R3511 T4980 T4982 auxpass was,identified
R3512 T4981 T4982 advmod initially,identified
R3513 T4982 T4982 ROOT identified,identified
R3514 T4983 T4982 prep as,identified
R3515 T4984 T4986 det an,transcript
R3516 T4985 T4986 amod upregulated,transcript
R3517 T4986 T4983 pobj transcript,as
R3518 T4987 T4986 prep in,transcript
R3519 T4988 T4990 det the,mouse
R3520 T4989 T4990 amod p 100H,mouse
R3521 T4990 T4987 pobj mouse,in
R3522 T4991 T4986 acl using,transcript
R3523 T4992 T4993 amod subtractive,hybridization
R3524 T4993 T4991 dobj hybridization,using
R3525 T4994 T4995 aux to,identify
R3526 T4995 T4991 xcomp identify,using
R3527 T4996 T4998 amod Sox6,targets
R3528 T4997 T4998 amod downstream,targets
R3529 T4998 T4995 dobj targets,identify
R3530 T4999 T4982 punct .,identified
R3531 T5000 T5002 det This,observation
R3532 T5001 T5002 amod initial,observation
R3533 T5002 T5004 nsubjpass observation,confirmed
R3534 T5003 T5004 auxpass was,confirmed
R3535 T5004 T5004 ROOT confirmed,confirmed
R3536 T5005 T5004 prep in,confirmed
R3537 T5006 T5009 det an,allele
R3538 T5007 T5009 amod independent,allele
R3539 T5008 T5009 amod knock-out,allele
R3540 T5009 T5005 pobj allele,in
R3541 T5010 T5009 prep of,allele
R3542 T5011 T5012 compound Sox6,[
R3543 T5012 T5010 pobj [,of
R3544 T5013 T5014 nummod 13,]
R3545 T5014 T5009 appos ],allele
R3546 T5015 T5004 advcl using,confirmed
R3547 T5016 T5019 amod real-time,reaction
R3548 T5017 T5019 compound polymerase,reaction
R3549 T5018 T5019 compound chain,reaction
R3550 T5019 T5015 dobj reaction,using
R3551 T5020 T5019 punct (,reaction
R3552 T5021 T5019 appos PCR,reaction
R3553 T5022 T5019 punct ),reaction
R3554 T5023 T5019 punct (,reaction
R3555 T5024 T5025 amod unpublished,data
R3556 T5025 T5019 appos data,reaction
R3557 T5026 T5019 punct ),reaction
R3558 T5027 T5004 punct .,confirmed
R3559 T5028 T5029 compound Real-time,PCR
R3560 T5029 T5031 nsubjpass PCR,used
R3561 T5030 T5031 auxpass was,used
R3562 T5031 T5031 ROOT used,used
R3563 T5032 T5033 aux to,quantitate
R3564 T5033 T5031 xcomp quantitate,used
R3565 T5034 T5036 det the,levels
R3566 T5035 T5036 compound expression,levels
R3567 T5036 T5033 dobj levels,quantitate
R3568 T5037 T5036 prep of,levels
R3569 T5038 T5040 amod other,genes
R3570 T5039 T5040 compound globin,genes
R3571 T5040 T5037 pobj genes,of
R3572 T5041 T5040 prep in,genes
R3573 T5042 T5043 amod p100H,mutant
R3574 T5043 T5047 amod mutant,livers
R3575 T5044 T5043 cc and,mutant
R3576 T5045 T5047 compound WT,livers
R3577 T5046 T5047 compound mouse,livers
R3578 T5047 T5041 pobj livers,in
R3579 T5048 T5033 prep at,quantitate
R3580 T5049 T5051 nummod two,stages
R3581 T5050 T5051 amod developmental,stages
R3582 T5051 T5048 pobj stages,at
R3583 T5052 T5051 punct ",",stages
R3584 T5053 T5057 nummod 15.5,dpc
R3585 T5054 T5057 nmod dpc,dpc
R3586 T5055 T5054 cc and,dpc
R3587 T5056 T5057 nummod 18.5,dpc
R3588 T5057 T5051 appos dpc,stages
R3589 T5058 T5031 punct .,used
R3590 T5059 T5060 mark As,shown
R3591 T5060 T5069 advcl shown,expressed
R3592 T5061 T5060 prep in,shown
R3593 T5062 T5061 pobj Figure,in
R3594 T5063 T5062 nummod 1,Figure
R3595 T5064 T5069 punct ",",expressed
R3596 T5065 T5067 det the,gene
R3597 T5066 T5067 amod ɛy,gene
R3598 T5067 T5069 nsubjpass gene,expressed
R3599 T5068 T5069 auxpass is,expressed
R3600 T5069 T5069 ROOT expressed,expressed
R3601 T5070 T5069 prep at,expressed
R3602 T5071 T5072 amod high,levels
R3603 T5072 T5070 pobj levels,at
R3604 T5073 T5072 prep at,levels
R3605 T5074 T5075 det both,time
R3606 T5075 T5076 compound time,points
R3607 T5076 T5073 pobj points,at
R3608 T5077 T5072 prep in,levels
R3609 T5078 T5079 amod mutant,mice
R3610 T5079 T5077 pobj mice,in
R3611 T5080 T5069 punct ",",expressed
R3612 T5081 T5069 prep in,expressed
R3613 T5082 T5081 pobj contrast,in
R3614 T5083 T5082 prep to,contrast
R3615 T5084 T5085 det the,decline
R3616 T5085 T5083 pobj decline,to
R3617 T5086 T5085 prep in,decline
R3618 T5087 T5086 pobj expression,in
R3619 T5088 T5085 acl observed,decline
R3620 T5089 T5088 prep in,observed
R3621 T5090 T5091 compound WT,mice
R3622 T5091 T5089 pobj mice,in
R3623 T5092 T5069 punct .,expressed
R3624 T5093 T5094 det No,difference
R3625 T5094 T5096 nsubjpass difference,seen
R3626 T5095 T5096 auxpass was,seen
R3627 T5096 T5096 ROOT seen,seen
R3628 T5097 T5096 prep between,seen
R3629 T5098 T5101 nmod WT,mice
R3630 T5099 T5098 cc and,WT
R3631 T5100 T5098 conj heterozygous,WT
R3632 T5101 T5097 pobj mice,between
R3633 T5102 T5104 punct (,data
R3634 T5103 T5104 amod unpublished,data
R3635 T5104 T5101 appos data,mice
R3636 T5105 T5101 punct ),mice
R3637 T5106 T5096 punct .,seen
R3638 T5107 T5124 advmod Interestingly,are
R3639 T5108 T5124 punct ",",are
R3640 T5109 T5111 det the,levels
R3641 T5110 T5111 compound expression,levels
R3642 T5111 T5124 nsubj levels,are
R3643 T5112 T5111 prep of,levels
R3644 T5113 T5118 det the,genes
R3645 T5114 T5118 amod other,genes
R3646 T5115 T5118 nummod two,genes
R3647 T5116 T5118 amod embryonic,genes
R3648 T5117 T5118 compound globin,genes
R3649 T5118 T5112 pobj genes,of
R3650 T5119 T5118 punct (,genes
R3651 T5120 T5118 appos ζ,genes
R3652 T5121 T5120 cc and,ζ
R3653 T5122 T5120 conj βh1,ζ
R3654 T5123 T5118 punct ),genes
R3655 T5124 T5124 ROOT are,are
R3656 T5125 T5124 advmod also,are
R3657 T5126 T5124 acomp higher,are
R3658 T5127 T5126 prep in,higher
R3659 T5128 T5130 amod p100H,mice
R3660 T5129 T5130 amod homozygous,mice
R3661 T5130 T5127 pobj mice,in
R3662 T5131 T5124 punct ",",are
R3663 T5132 T5124 prep compared,are
R3664 T5133 T5132 prep with,compared
R3665 T5134 T5135 compound WT,mice
R3666 T5135 T5133 pobj mice,with
R3667 T5136 T5124 punct ",",are
R3668 T5137 T5124 cc but,are
R3669 T5138 T5144 prep to,seen
R3670 T5139 T5142 det a,extent
R3671 T5140 T5141 advmod much,lesser
R3672 T5141 T5142 amod lesser,extent
R3673 T5142 T5138 pobj extent,to
R3674 T5143 T5144 mark than,seen
R3675 T5144 T5124 conj seen,are
R3676 T5145 T5144 prep for,seen
R3677 T5146 T5147 amod ɛy,globin
R3678 T5147 T5145 pobj globin,for
R3679 T5148 T5144 prep at,seen
R3680 T5149 T5150 nummod 18.5,dpc
R3681 T5150 T5148 pobj dpc,at
R3682 T5151 T5152 punct (,Figure
R3683 T5152 T5144 conj Figure,seen
R3684 T5153 T5152 nummod 1,Figure
R3685 T5154 T5152 punct ),Figure
R3686 T5155 T5124 punct .,are
R3687 T5156 T5165 advmod Moreover,is
R3688 T5157 T5165 punct ",",is
R3689 T5158 T5160 det the,level
R3690 T5159 T5160 compound expression,level
R3691 T5160 T5165 nsubj level,is
R3692 T5161 T5160 prep of,level
R3693 T5162 T5164 amod adult,globin
R3694 T5163 T5164 compound β,globin
R3695 T5164 T5161 pobj globin,of
R3696 T5165 T5165 ROOT is,is
R3697 T5166 T5165 advmod also,is
R3698 T5167 T5168 advmod somewhat,higher
R3699 T5168 T5165 acomp higher,is
R3700 T5169 T5168 prep in,higher
R3701 T5170 T5172 amod p100H,mice
R3702 T5171 T5172 amod homozygous,mice
R3703 T5172 T5169 pobj mice,in
R3704 T5173 T5168 prep than,higher
R3705 T5174 T5173 prep in,than
R3706 T5175 T5176 compound WT,mice
R3707 T5176 T5174 pobj mice,in
R3708 T5177 T5165 prep at,is
R3709 T5178 T5179 nummod 18.5,dpc
R3710 T5179 T5177 pobj dpc,at
R3711 T5180 T5181 punct (,Figure
R3712 T5181 T5165 npadvmod Figure,is
R3713 T5182 T5181 nummod 1,Figure
R3714 T5183 T5181 punct ),Figure
R3715 T5184 T5165 punct .,is
R3716 T5185 T5186 amod Perinatal,lethality
R3717 T5186 T5200 nsubj lethality,precludes
R3718 T5187 T5186 prep of,lethality
R3719 T5188 T5189 amod mutant,mice
R3720 T5189 T5187 pobj mice,of
R3721 T5190 T5192 punct (,from
R3722 T5191 T5192 advmod presumably,from
R3723 T5192 T5186 prep from,lethality
R3724 T5193 T5195 det the,defect
R3725 T5194 T5195 compound heart,defect
R3726 T5195 T5192 pobj defect,from
R3727 T5196 T5200 nsubj [,precludes
R3728 T5197 T5198 nummod 14,]
R3729 T5198 T5196 appos ],[
R3730 T5199 T5196 punct ),[
R3731 T5200 T5200 ROOT precludes,precludes
R3732 T5201 T5200 dobj us,precludes
R3733 T5202 T5200 prep from,precludes
R3734 T5203 T5202 pcomp evaluating,from
R3735 T5204 T5206 amod postnatal,expression
R3736 T5205 T5206 compound globin,expression
R3737 T5206 T5203 dobj expression,evaluating
R3738 T5207 T5200 punct .,precludes
R3739 T5208 T5209 det The,graphs
R3740 T5209 T5213 nsubj graphs,illustrate
R3741 T5210 T5209 prep in,graphs
R3742 T5211 T5210 pobj Figure,in
R3743 T5212 T5211 nummod 1,Figure
R3744 T5213 T5213 ROOT illustrate,illustrate
R3745 T5214 T5215 amod real,time
R3746 T5215 T5217 compound time,results
R3747 T5216 T5217 compound PCR,results
R3748 T5217 T5213 dobj results,illustrate
R3749 T5218 T5220 nsubjpass that,performed
R3750 T5219 T5220 auxpass were,performed
R3751 T5220 T5217 relcl performed,results
R3752 T5221 T5220 prep in,performed
R3753 T5222 T5221 pobj triplicate,in
R3754 T5223 T5222 punct (,triplicate
R3755 T5224 T5225 amod standard,deviation
R3756 T5225 T5230 nsubjpass deviation,shown
R3757 T5226 T5225 prep of,deviation
R3758 T5227 T5228 det the,data
R3759 T5228 T5226 pobj data,of
R3760 T5229 T5230 auxpass is,shown
R3761 T5230 T5213 ccomp shown,illustrate
R3762 T5231 T5230 agent by,shown
R3763 T5232 T5233 compound error,bars
R3764 T5233 T5231 pobj bars,by
R3765 T5234 T5230 punct ),shown
R3766 T5235 T5213 punct .,illustrate
R3767 T5236 T5242 mark Because,performed
R3768 T5237 T5242 nsubjpass all,performed
R3769 T5238 T5237 prep of,all
R3770 T5239 T5240 det the,assays
R3771 T5240 T5238 pobj assays,of
R3772 T5241 T5242 auxpass were,performed
R3773 T5242 T5256 advcl performed,are
R3774 T5243 T5242 prep at,performed
R3775 T5244 T5246 det the,time
R3776 T5245 T5246 amod same,time
R3777 T5246 T5243 pobj time,at
R3778 T5247 T5242 prep with,performed
R3779 T5248 T5251 det the,control
R3780 T5249 T5251 amod same,control
R3781 T5250 T5251 amod internal,control
R3782 T5251 T5247 pobj control,with
R3783 T5252 T5256 punct ",",are
R3784 T5253 T5254 det the,levels
R3785 T5254 T5256 nsubj levels,are
R3786 T5255 T5254 acl shown,levels
R3787 T5256 T5256 ROOT are,are
R3788 T5257 T5258 amod relative,levels
R3789 T5258 T5256 attr levels,are
R3790 T5259 T5256 cc and,are
R3791 T5260 T5256 conj are,are
R3792 T5261 T5262 advmod thus,comparable
R3793 T5262 T5260 acomp comparable,are
R3794 T5263 T5260 prep across,are
R3795 T5264 T5265 det all,samples
R3796 T5265 T5263 pobj samples,across
R3797 T5266 T5260 cc and,are
R3798 T5267 T5260 conj are,are
R3799 T5268 T5267 prep in,are
R3800 T5269 T5268 pobj agreement,in
R3801 T5270 T5269 prep with,agreement
R3802 T5271 T5272 advmod previously,published
R3803 T5272 T5273 amod published,results
R3804 T5273 T5270 pobj results,with
R3805 T5274 T5273 prep for,results
R3806 T5275 T5277 nmod WT,mice
R3807 T5276 T5277 amod fetal,mice
R3808 T5277 T5274 pobj mice,for
R3809 T5278 T5280 nmod [,]
R3810 T5279 T5280 nummod 29,]
R3811 T5280 T5277 appos ],mice
R3812 T5281 T5256 punct .,are
R3813 T5282 T5283 nsubj We,note
R3814 T5283 T5283 ROOT note,note
R3815 T5284 T5302 mark that,is
R3816 T5285 T5286 det the,level
R3817 T5286 T5302 nsubj level,is
R3818 T5287 T5286 prep of,level
R3819 T5288 T5289 amod ɛy,expression
R3820 T5289 T5287 pobj expression,of
R3821 T5290 T5286 prep in,level
R3822 T5291 T5292 det the,livers
R3823 T5292 T5290 pobj livers,in
R3824 T5293 T5292 prep of,livers
R3825 T5294 T5301 nummod 15.5,mice
R3826 T5295 T5301 nmod dpc,mice
R3827 T5296 T5295 cc and,dpc
R3828 T5297 T5298 nummod 18.5,dpc
R3829 T5298 T5301 nmod dpc,mice
R3830 T5299 T5301 amod homozygous,mice
R3831 T5300 T5301 amod mutant,mice
R3832 T5301 T5293 pobj mice,of
R3833 T5302 T5283 ccomp is,note
R3834 T5303 T5304 advmod statistically,equivalent
R3835 T5304 T5302 acomp equivalent,is
R3836 T5305 T5304 prep to,equivalent
R3837 T5306 T5307 det the,level
R3838 T5307 T5305 pobj level,to
R3839 T5308 T5307 prep of,level
R3840 T5309 T5312 compound βmaj,expression
R3841 T5310 T5312 compound /,expression
R3842 T5311 T5312 compound min,expression
R3843 T5312 T5308 pobj expression,of
R3844 T5313 T5307 prep in,level
R3845 T5314 T5315 det the,livers
R3846 T5315 T5313 pobj livers,in
R3847 T5316 T5315 prep of,livers
R3848 T5317 T5324 nummod 15.5,mice
R3849 T5318 T5324 nmod dpc,mice
R3850 T5319 T5318 cc and,dpc
R3851 T5320 T5321 nummod 18.5,dpc
R3852 T5321 T5324 nmod dpc,mice
R3853 T5322 T5324 amod homozygous,mice
R3854 T5323 T5324 compound WT,mice
R3855 T5324 T5316 pobj mice,of
R3856 T5325 T5283 punct .,note
R4427 T6364 T6365 compound Studies,Using
R4428 T6365 T6365 ROOT Using,Using
R4429 T6366 T6368 compound GM979,Indicate
R4430 T6367 T6368 compound Cells,Indicate
R4431 T6368 T6365 dobj Indicate,Using
R4432 T6369 T6365 nsubj That,Using
R4433 T6370 T6372 nsubj Sox6,Represses
R4434 T6371 T6372 advmod Directly,Represses
R4435 T6372 T6369 nsubj Represses,That
R4436 T6373 T6374 det the,ɛy
R4437 T6374 T6376 compound ɛy,Promoter
R4438 T6375 T6376 compound Gene,Promoter
R4439 T6376 T6372 dobj Promoter,Represses
R4440 T6377 T6376 prep at,Promoter
R4441 T6378 T6383 det the,assays
R4442 T6379 T6380 compound Transcriptional,Level
R4443 T6380 T6383 nmod Level,assays
R4444 T6381 T6383 amod Real-time,assays
R4445 T6382 T6383 compound PCR,assays
R4446 T6383 T6377 pobj assays,at
R4447 T6384 T6383 punct (,assays
R4448 T6385 T6383 appos Figure,assays
R4449 T6386 T6385 nummod 1,Figure
R4450 T6387 T6385 punct ),Figure
R4451 T6388 T6397 nmod measure,activity
R4452 T6389 T6390 amod steady-state,levels
R4453 T6390 T6388 dobj levels,measure
R4454 T6391 T6390 prep of,levels
R4455 T6392 T6393 compound ɛy,mRNA
R4456 T6393 T6391 pobj mRNA,of
R4457 T6394 T6393 punct ",",mRNA
R4458 T6395 T6397 neg not,activity
R4459 T6396 T6397 amod transcriptional,activity
R4460 T6397 T6383 appos activity,assays
R4461 T6398 T6397 prep of,activity
R4462 T6399 T6401 det the,promoter
R4463 T6400 T6401 amod ɛy,promoter
R4464 T6401 T6398 pobj promoter,of
R4465 T6402 T6365 punct .,Using
R4466 T6403 T6404 aux To,investigate
R4467 T6404 T6420 advcl investigate,used
R4468 T6405 T6408 mark whether,acts
R4469 T6406 T6408 nsubj Sox6,acts
R4470 T6407 T6408 advmod directly,acts
R4471 T6408 T6404 ccomp acts,investigate
R4472 T6409 T6408 prep on,acts
R4473 T6410 T6413 det the,promoter
R4474 T6411 T6413 amod ɛy,promoter
R4475 T6412 T6413 compound gene,promoter
R4476 T6413 T6409 pobj promoter,on
R4477 T6414 T6413 prep at,promoter
R4478 T6415 T6417 det the,level
R4479 T6416 T6417 amod transcriptional,level
R4480 T6417 T6414 pobj level,at
R4481 T6418 T6420 punct ",",used
R4482 T6419 T6420 nsubj we,used
R4483 T6420 T6420 ROOT used,used
R4484 T6421 T6426 det an,assay
R4485 T6422 T6426 nmod in,assay
R4486 T6423 T6426 amod vitro,assay
R4487 T6424 T6426 nmod transient,assay
R4488 T6425 T6426 compound transfection,assay
R4489 T6426 T6420 dobj assay,used
R4490 T6427 T6426 cc and,assay
R4491 T6428 T6429 compound GM979,cells
R4492 T6429 T6426 conj cells,assay
R4493 T6430 T6420 punct ",",used
R4494 T6431 T6435 det a,line
R4495 T6432 T6435 amod murine,line
R4496 T6433 T6435 amod erythroleukemic,line
R4497 T6434 T6435 compound cell,line
R4498 T6435 T6420 dobj line,used
R4499 T6436 T6437 nsubj that,expresses
R4500 T6437 T6435 relcl expresses,line
R4501 T6438 T6439 det both,ɛy
R4502 T6439 T6437 dobj ɛy,expresses
R4503 T6440 T6439 cc and,ɛy
R4504 T6441 T6443 amod adult,globins
R4505 T6442 T6443 compound beta,globins
R4506 T6443 T6446 dep globins,]
R4507 T6444 T6446 nmod [,]
R4508 T6445 T6446 nummod 30,]
R4509 T6446 T6439 conj ],ɛy
R4510 T6447 T6420 punct .,used
R4511 T6448 T6449 nsubj We,generated
R4512 T6449 T6449 ROOT generated,generated
R4513 T6450 T6453 det an,reporter
R4514 T6451 T6453 amod ɛy,reporter
R4515 T6452 T6453 compound promoter,reporter
R4516 T6453 T6454 nsubj reporter,construct
R4517 T6454 T6449 ccomp construct,generated
R4518 T6455 T6456 punct (,E-Luc
R4519 T6456 T6454 dep E-Luc,construct
R4520 T6457 T6456 punct ),E-Luc
R4521 T6458 T6454 prep by,construct
R4522 T6459 T6458 pcomp fusing,by
R4523 T6460 T6461 det a,micro-LCR
R4524 T6461 T6459 dobj micro-LCR,fusing
R4525 T6462 T6463 punct (,μLCR
R4526 T6463 T6461 appos μLCR,micro-LCR
R4527 T6464 T6463 punct ),μLCR
R4528 T6465 T6461 conj element,micro-LCR
R4529 T6466 T6465 punct (,element
R4530 T6467 T6468 nummod 2.5,kb
R4531 T6468 T6465 appos kb,element
R4532 T6469 T6465 punct ),element
R4533 T6470 T6472 nmod [,]
R4534 T6471 T6472 nummod 31,]
R4535 T6472 T6461 appos ],micro-LCR
R4536 T6473 T6459 prep to,fusing
R4537 T6474 T6477 det the,promoter
R4538 T6475 T6477 amod ɛy,promoter
R4539 T6476 T6477 amod proximal,promoter
R4540 T6477 T6473 pobj promoter,to
R4541 T6478 T6477 punct (,promoter
R4542 T6479 T6480 nummod 2.2,kb
R4543 T6480 T6477 appos kb,promoter
R4544 T6481 T6477 punct ),promoter
R4545 T6482 T6459 punct ",",fusing
R4546 T6483 T6454 advcl followed,construct
R4547 T6484 T6483 agent by,followed
R4548 T6485 T6488 det the,gene
R4549 T6486 T6488 compound luciferase,gene
R4550 T6487 T6488 compound reporter,gene
R4551 T6488 T6484 pobj gene,by
R4552 T6489 T6483 punct ",",followed
R4553 T6490 T6491 mark as,shown
R4554 T6491 T6454 advcl shown,construct
R4555 T6492 T6491 prep in,shown
R4556 T6493 T6492 pobj Figure,in
R4557 T6494 T6493 nummod 2A,Figure
R4558 T6495 T6496 punct (,detailed
R4559 T6496 T6454 advcl detailed,construct
R4560 T6497 T6496 prep in,detailed
R4561 T6498 T6497 pobj Materials,in
R4562 T6499 T6498 cc and,Materials
R4563 T6500 T6498 conj Methods,Materials
R4564 T6501 T6496 punct ),detailed
R4565 T6502 T6449 punct .,generated
R4566 T6503 T6512 nsubj Overexpression,leads
R4567 T6504 T6503 prep of,Overexpression
R4568 T6505 T6504 pobj Sox6,of
R4569 T6506 T6503 prep in,Overexpression
R4570 T6507 T6508 compound GM979,cells
R4571 T6508 T6506 pobj cells,in
R4572 T6509 T6503 agent by,Overexpression
R4573 T6510 T6511 amod transient,transfection
R4574 T6511 T6509 pobj transfection,by
R4575 T6512 T6512 ROOT leads,leads
R4576 T6513 T6512 prep to,leads
R4577 T6514 T6516 det a,repression
R4578 T6515 T6516 amod dosage-dependent,repression
R4579 T6516 T6513 pobj repression,to
R4580 T6517 T6516 prep of,repression
R4581 T6518 T6520 amod E-Luc,activity
R4582 T6519 T6520 compound reporter,activity
R4583 T6520 T6517 pobj activity,of
R4584 T6521 T6523 punct (,2B
R4585 T6522 T6523 compound Figure,2B
R4586 T6523 T6520 appos 2B,activity
R4587 T6524 T6520 punct ),activity
R4588 T6525 T6512 punct .,leads
R4589 T6526 T6551 prep In,fails
R4590 T6527 T6526 pobj contrast,In
R4591 T6528 T6551 punct ",",fails
R4592 T6529 T6551 nsubj overexpression,fails
R4593 T6530 T6529 prep of,overexpression
R4594 T6531 T6534 det a,protein
R4595 T6532 T6534 amod truncated,protein
R4596 T6533 T6534 compound Sox6,protein
R4597 T6534 T6530 pobj protein,of
R4598 T6535 T6536 nsubj that,lacks
R4599 T6536 T6534 relcl lacks,protein
R4600 T6537 T6539 poss its,domain
R4601 T6538 T6539 compound HMG,domain
R4602 T6539 T6536 dobj domain,lacks
R4603 T6540 T6542 nmod [,]
R4604 T6541 T6542 nummod 32,]
R4605 T6542 T6539 appos ],domain
R4606 T6543 T6542 punct (,]
R4607 T6544 T6542 amod similar,]
R4608 T6545 T6544 prep to,similar
R4609 T6546 T6549 det the,allele
R4610 T6547 T6549 amod p 100H,allele
R4611 T6548 T6549 compound mouse,allele
R4612 T6549 T6545 pobj allele,to
R4613 T6550 T6542 punct ),]
R4614 T6551 T6551 ROOT fails,fails
R4615 T6552 T6553 aux to,repress
R4616 T6553 T6551 xcomp repress,fails
R4617 T6554 T6555 amod E-Luc,activity
R4618 T6555 T6553 dobj activity,repress
R4619 T6556 T6558 punct (,2B
R4620 T6557 T6558 compound Figure,2B
R4621 T6558 T6555 appos 2B,activity
R4622 T6559 T6558 punct ),2B
R4623 T6560 T6551 punct .,fails
R4624 T6561 T6562 det These,data
R4625 T6562 T6563 nsubj data,indicate
R4626 T6563 T6563 ROOT indicate,indicate
R4627 T6564 T6568 mark that,repress
R4628 T6565 T6566 amod Sox6,acts
R4629 T6566 T6568 nsubj acts,repress
R4630 T6567 T6568 aux to,repress
R4631 T6568 T6563 ccomp repress,indicate
R4632 T6569 T6571 det the,promoter
R4633 T6570 T6571 amod ɛy,promoter
R4634 T6571 T6568 dobj promoter,repress
R4635 T6572 T6571 prep at,promoter
R4636 T6573 T6575 det the,level
R4637 T6574 T6575 amod transcriptional,level
R4638 T6575 T6572 pobj level,at
R4639 T6576 T6563 punct .,indicate
R4640 T6577 T6580 nsubjpass Sox6,shown
R4641 T6578 T6580 aux has,shown
R4642 T6579 T6580 auxpass been,shown
R4643 T6580 T6580 ROOT shown,shown
R4644 T6581 T6582 aux to,act
R4645 T6582 T6580 xcomp act,shown
R4646 T6583 T6582 prep as,act
R4647 T6584 T6585 det a,repressor
R4648 T6585 T6583 pobj repressor,as
R4649 T6586 T6582 cc and,act
R4650 T6587 T6588 aux to,interact
R4651 T6588 T6582 conj interact,act
R4652 T6589 T6588 prep with,interact
R4653 T6590 T6593 det a,co-repressor
R4654 T6591 T6592 advmod widely,expressed
R4655 T6592 T6593 amod expressed,co-repressor
R4656 T6593 T6589 pobj co-repressor,with
R4657 T6594 T6593 punct ",",co-repressor
R4658 T6595 T6593 appos CtBP2,co-repressor
R4659 T6596 T6588 punct ",",interact
R4660 T6597 T6588 prep on,interact
R4661 T6598 T6600 det the,promoter
R4662 T6599 T6600 amod fgf-3,promoter
R4663 T6600 T6597 pobj promoter,on
R4664 T6601 T6603 nmod [,]
R4665 T6602 T6601 nummod 5,[
R4666 T6603 T6600 appos ],promoter
R4667 T6604 T6580 punct .,shown
R4668 T6605 T6607 nsubjpass CtBP2,expressed
R4669 T6606 T6607 auxpass is,expressed
R4670 T6607 T6607 ROOT expressed,expressed
R4671 T6608 T6607 prep in,expressed
R4672 T6609 T6610 compound GM979,cells
R4673 T6610 T6608 pobj cells,in
R4674 T6611 T6613 punct (,data
R4675 T6612 T6613 amod unpublished,data
R4676 T6613 T6610 appos data,cells
R4677 T6614 T6607 punct ),expressed
R4678 T6615 T6607 punct .,expressed
R4679 T6616 T6617 aux To,investigate
R4680 T6617 T6634 advcl investigate,introduced
R4681 T6618 T6624 mark whether,required
R4682 T6619 T6620 det the,interaction
R4683 T6620 T6624 nsubjpass interaction,required
R4684 T6621 T6620 prep with,interaction
R4685 T6622 T6621 pobj CtBP2,with
R4686 T6623 T6624 auxpass is,required
R4687 T6624 T6617 ccomp required,investigate
R4688 T6625 T6624 prep for,required
R4689 T6626 T6627 amod Sox6,repression
R4690 T6627 T6625 pobj repression,for
R4691 T6628 T6627 prep of,repression
R4692 T6629 T6631 det the,promoter
R4693 T6630 T6631 amod ɛy,promoter
R4694 T6631 T6628 pobj promoter,of
R4695 T6632 T6634 punct ",",introduced
R4696 T6633 T6634 nsubj we,introduced
R4697 T6634 T6634 ROOT introduced,introduced
R4698 T6635 T6637 det a,mutation
R4699 T6636 T6637 compound point,mutation
R4700 T6637 T6634 dobj mutation,introduced
R4701 T6638 T6637 punct (,mutation
R4702 T6639 T6637 appos L386H,mutation
R4703 T6640 T6637 punct ),mutation
R4704 T6641 T6634 prep in,introduced
R4705 T6642 T6644 det the,protein
R4706 T6643 T6644 amod Sox6,protein
R4707 T6644 T6641 pobj protein,in
R4708 T6645 T6649 nsubjpass that,reported
R4709 T6646 T6649 aux has,reported
R4710 T6647 T6649 auxpass been,reported
R4711 T6648 T6649 advmod previously,reported
R4712 T6649 T6644 relcl reported,protein
R4713 T6650 T6651 aux to,be
R4714 T6651 T6649 xcomp be,reported
R4715 T6652 T6651 acomp sufficient,be
R4716 T6653 T6654 aux to,abolish
R4717 T6654 T6652 xcomp abolish,sufficient
R4718 T6655 T6656 amod Sox6-CtBP2,interaction
R4719 T6656 T6654 dobj interaction,abolish
R4720 T6657 T6659 nmod [,]
R4721 T6658 T6657 nummod 5,[
R4722 T6659 T6644 appos ],protein
R4723 T6660 T6634 punct .,introduced
R4724 T6661 T6664 det This,change
R4725 T6662 T6664 amod amino,change
R4726 T6663 T6664 compound acid,change
R4727 T6664 T6665 nsubj change,is
R4728 T6665 T6665 ROOT is,is
R4729 T6666 T6665 neg not,is
R4730 T6667 T6665 prep in,is
R4731 T6668 T6672 det the,domain
R4732 T6669 T6670 compound HMG,DNA
R4733 T6670 T6672 compound DNA,domain
R4734 T6671 T6672 amod binding,domain
R4735 T6672 T6667 pobj domain,in
R4736 T6673 T6665 punct .,is
R4737 T6674 T6681 advmod However,retains
R4738 T6675 T6681 punct ",",retains
R4739 T6676 T6678 det this,version
R4740 T6677 T6678 amod mutant,version
R4741 T6678 T6681 nsubj version,retains
R4742 T6679 T6678 prep of,version
R4743 T6680 T6679 pobj Sox6,of
R4744 T6681 T6681 ROOT retains,retains
R4745 T6682 T6683 det the,ability
R4746 T6683 T6681 dobj ability,retains
R4747 T6684 T6685 aux to,repress
R4748 T6685 T6683 acl repress,ability
R4749 T6686 T6688 det the,promoter
R4750 T6687 T6688 amod ɛy,promoter
R4751 T6688 T6685 dobj promoter,repress
R4752 T6689 T6688 prep in,promoter
R4753 T6690 T6692 det the,assay
R4754 T6691 T6692 compound transfection,assay
R4755 T6692 T6689 pobj assay,in
R4756 T6693 T6695 punct (,2B
R4757 T6694 T6695 compound Figure,2B
R4758 T6695 T6692 appos 2B,assay
R4759 T6696 T6692 punct ),assay
R4760 T6697 T6681 punct ",",retains
R4761 T6698 T6681 advcl indicating,retains
R4762 T6699 T6701 mark that,represses
R4763 T6700 T6701 nsubj Sox6,represses
R4764 T6701 T6698 ccomp represses,indicating
R4765 T6702 T6704 det the,promoter
R4766 T6703 T6704 amod ɛy,promoter
R4767 T6704 T6701 dobj promoter,represses
R4768 T6705 T6704 prep in,promoter
R4769 T6706 T6708 det a,manner
R4770 T6707 T6708 amod CtBP2-independent,manner
R4771 T6708 T6705 pobj manner,in
R4772 T6709 T6681 punct .,retains
R4773 T6710 T6711 compound Deletion,analysis
R4774 T6711 T6723 nsubj analysis,defined
R4775 T6712 T6711 prep of,analysis
R4776 T6713 T6715 det the,promoter
R4777 T6714 T6715 amod ɛy,promoter
R4778 T6715 T6712 pobj promoter,of
R4779 T6716 T6711 punct ",",analysis
R4780 T6717 T6718 mark as,shown
R4781 T6718 T6711 advcl shown,analysis
R4782 T6719 T6718 prep in,shown
R4783 T6720 T6719 pobj Figure,in
R4784 T6721 T6720 nummod 2C,Figure
R4785 T6722 T6723 punct ",",defined
R4786 T6723 T6723 ROOT defined,defined
R4787 T6724 T6725 det a,region
R4788 T6725 T6723 dobj region,defined
R4789 T6726 T6727 punct (,−
R4790 T6727 T6728 amod −,63
R4791 T6728 T6723 npadvmod 63,defined
R4792 T6729 T6728 prep to,63
R4793 T6730 T6729 pobj −,to
R4794 T6731 T6730 appos 37,−
R4795 T6732 T6730 punct ),−
R4796 T6733 T6729 prep within,to
R4797 T6734 T6737 det the,promoter
R4798 T6735 T6737 amod ɛy,promoter
R4799 T6736 T6737 amod proximal,promoter
R4800 T6737 T6733 pobj promoter,within
R4801 T6738 T6739 nsubj that,is
R4802 T6739 T6737 relcl is,promoter
R4803 T6740 T6739 acomp critical,is
R4804 T6741 T6740 prep for,critical
R4805 T6742 T6743 amod Sox6,repression
R4806 T6743 T6741 pobj repression,for
R4807 T6744 T6723 punct .,defined
R4808 T6745 T6750 nsubj Analysis,reveals
R4809 T6746 T6745 prep of,Analysis
R4810 T6747 T6749 det this,region
R4811 T6748 T6749 amod short,region
R4812 T6749 T6746 pobj region,of
R4813 T6750 T6750 ROOT reveals,reveals
R4814 T6751 T6755 nummod two,sites
R4815 T6752 T6755 amod Sox/Sox6,sites
R4816 T6753 T6755 nmod consensus,sites
R4817 T6754 T6755 amod binding,sites
R4818 T6755 T6750 dobj sites,reveals
R4819 T6756 T6758 nmod [,]
R4820 T6757 T6758 nummod 5,]
R4821 T6758 T6761 compound ],3A
R4822 T6759 T6760 punct (,Figure
R4823 T6760 T6761 compound Figure,3A
R4824 T6761 T6750 oprd 3A,reveals
R4825 T6762 T6750 punct ),reveals
R4826 T6763 T6750 punct .,reveals
R5604 T8230 T8230 ROOT corresponds,corresponds
R5605 T8231 T8230 prep to,corresponds
R5606 T8232 T8234 det the,region
R5607 T8233 T8234 amod critical,region
R5608 T8234 T8231 pobj region,to
R5609 T8140 T8155 nsubj EMSA,repress
R5610 T8141 T8140 cc and,EMSA
R5611 T8142 T8144 compound ChIP,Show
R5612 T8235 T8234 prep of,region
R5613 T8143 T8144 compound Assays,Show
R5614 T8144 T8140 conj Show,EMSA
R5615 T8145 T8148 mark that,Binds
R5616 T8236 T8238 det the,promoter
R5617 T8146 T8148 nsubj Sox6,Binds
R5618 T8147 T8148 advmod Directly,Binds
R5619 T8148 T8155 advcl Binds,repress
R5620 T8149 T8148 prep to,Binds
R5621 T8237 T8238 amod ɛy,promoter
R5622 T8150 T8151 det the,ɛy
R5623 T8151 T8155 nsubj ɛy,repress
R5624 T8152 T8153 compound Promoter,Sox6
R5625 T8153 T8151 appos Sox6,ɛy
R5626 T8238 T8235 pobj promoter,of
R5627 T8154 T8155 aux might,repress
R5628 T8155 T8155 ROOT repress,repress
R5629 T8239 T8238 acl defined,promoter
R5630 T8156 T8158 det the,promoter
R5631 T8157 T8158 amod ɛy,promoter
R5632 T8158 T8155 dobj promoter,repress
R5633 T8240 T8239 prep in,defined
R5634 T8159 T8155 punct ",",repress
R5635 T8160 T8161 preconj either,through
R5636 T8161 T8155 prep through,repress
R5637 T8162 T8164 amod direct,contact
R5638 T8241 T8244 poss our,analyses
R5639 T8163 T8164 amod physical,contact
R5640 T8164 T8161 pobj contact,through
R5641 T8165 T8164 prep with,contact
R5642 T8242 T8243 compound promoter,deletion
R5643 T8166 T8167 det the,promoter
R5644 T8167 T8165 pobj promoter,with
R5645 T8168 T8165 cc or,with
R5646 T8243 T8244 compound deletion,analyses
R5647 T8169 T8155 prep by,repress
R5648 T8170 T8169 pcomp regulating,by
R5649 T8171 T8170 dobj intermediates,regulating
R5650 T8244 T8240 pobj analyses,in
R5651 T8172 T8171 acl affecting,intermediates
R5652 T8173 T8175 det the,promoter
R5653 T8245 T8230 punct .,corresponds
R5654 T8174 T8175 amod ɛy,promoter
R5655 T8175 T8172 dobj promoter,affecting
R5656 T8176 T8155 punct .,repress
R5657 T8177 T8178 aux To,investigate
R5658 T8178 T8191 advcl investigate,performed
R5659 T8179 T8183 mark whether,associated
R5660 T8180 T8183 nsubjpass Sox6,associated
R5661 T8181 T8183 auxpass is,associated
R5662 T8246 T8247 det This,probe
R5663 T8182 T8183 advmod directly,associated
R5664 T8183 T8178 ccomp associated,investigate
R5665 T8184 T8183 prep with,associated
R5666 T8185 T8187 det the,promoter
R5667 T8247 T8248 nsubj probe,contains
R5668 T8186 T8187 amod ɛy,promoter
R5669 T8187 T8184 pobj promoter,with
R5670 T8188 T8191 punct ",",performed
R5671 T8189 T8191 nsubj we,performed
R5672 T8248 T8248 ROOT contains,contains
R5673 T8190 T8191 advmod first,performed
R5674 T8191 T8191 ROOT performed,performed
R5675 T8192 T8194 amod electrophoretic,shift
R5676 T8193 T8194 compound mobility,shift
R5677 T8194 T8195 compound shift,assays
R5678 T8195 T8191 dobj assays,performed
R5679 T8249 T8253 nummod two,sites
R5680 T8196 T8195 punct (,assays
R5681 T8197 T8195 appos EMSA,assays
R5682 T8198 T8195 punct ),assays
R5683 T8199 T8191 advcl using,performed
R5684 T8200 T8202 det a,Sox6
R5685 T8250 T8253 compound consensus,sites
R5686 T8201 T8202 amod c-Myc-tagged,Sox6
R5687 T8251 T8253 nmod Sox/Sox6,sites
R5688 T8202 T8199 dobj Sox6,using
R5689 T8203 T8199 prep in,using
R5690 T8204 T8207 det a,transcription/translation
R5691 T8252 T8253 amod binding,sites
R5692 T8205 T8207 nmod reticulocyte,transcription/translation
R5693 T8206 T8207 amod lysate-based,transcription/translation
R5694 T8207 T8203 pobj transcription/translation,in
R5695 T8253 T8248 dobj sites,contains
R5696 T8208 T8207 prep in,transcription/translation
R5697 T8209 T8210 amod vitro,system
R5698 T8254 T8248 punct .,contains
R5699 T8210 T8208 pobj system,in
R5700 T8211 T8191 punct .,performed
R5701 T8255 T8256 advmod Also,included
R5702 T8212 T8213 det The,probes
R5703 T8213 T8216 nsubjpass probes,listed
R5704 T8214 T8213 acl used,probes
R5705 T8215 T8216 auxpass are,listed
R5706 T8216 T8216 ROOT listed,listed
R5707 T8217 T8216 prep in,listed
R5708 T8256 T8256 ROOT included,included
R5709 T8218 T8219 compound Figure,3A
R5710 T8219 T8217 pobj 3A,in
R5711 T8220 T8216 punct .,listed
R5712 T8257 T8256 prep in,included
R5713 T8221 T8224 det The,pair
R5714 T8222 T8223 nummod 36,base
R5715 T8223 T8224 compound base,pair
R5716 T8258 T8259 poss our,EMSA
R5717 T8224 T8224 ROOT pair,pair
R5718 T8225 T8224 punct (,pair
R5719 T8226 T8224 appos bp,pair
R5720 T8259 T8257 pobj EMSA,in
R5721 T8227 T8224 punct ),pair
R5722 T8228 T8229 compound WT,probe
R5723 T8229 T8230 nsubj probe,corresponds
R5724 T8260 T8256 auxpass are,included
R5725 T8261 T8263 nummod three,probes
R5726 T8262 T8263 amod mutated,probes
R5727 T8263 T8256 nsubjpass probes,included
R5728 T8327 T8323 pobj protein,by
R5729 T8264 T8265 nsubj that,are
R5730 T8328 T8322 punct .,shifted
R5731 T8329 T8336 advmod Moreover,supershift
R5732 T8330 T8336 punct ",",supershift
R5733 T8265 T8263 relcl are,probes
R5734 T8331 T8332 preconj both,c-Myc
R5735 T8332 T8336 nsubj c-Myc,supershift
R5736 T8266 T8265 punct ",",are
R5737 T8333 T8332 cc and,c-Myc
R5738 T8334 T8332 conj Sox6,c-Myc
R5739 T8335 T8332 conj antibodies,c-Myc
R5740 T8267 T8268 preconj either,truncated
R5741 T8336 T8336 ROOT supershift,supershift
R5742 T8337 T8338 det the,band
R5743 T8268 T8265 acomp truncated,are
R5744 T8338 T8336 dobj band,supershift
R5745 T8339 T8336 punct ",",supershift
R5746 T8340 T8336 advcl indicating,supershift
R5747 T8269 T8268 punct (,truncated
R5748 T8341 T8344 mark that,is
R5749 T8342 T8343 det the,binding
R5750 T8343 T8344 nsubj binding,is
R5751 T8270 T8268 npadvmod M1,truncated
R5752 T8344 T8340 ccomp is,indicating
R5753 T8345 T8344 acomp Sox6-specific,is
R5754 T8346 T8336 punct .,supershift
R5755 T8347 T8348 aux To,rule
R5756 T8348 T8366 advcl rule,used
R5757 T8349 T8348 prt out,rule
R5758 T8271 T8268 punct ),truncated
R5759 T8350 T8351 det the,possibility
R5760 T8351 T8348 dobj possibility,rule
R5761 T8352 T8357 mark that,binds
R5762 T8272 T8265 punct ",",are
R5763 T8353 T8355 det the,tag
R5764 T8354 T8355 amod c-Myc,tag
R5765 T8355 T8357 nsubj tag,binds
R5766 T8273 T8265 cc or,are
R5767 T8356 T8355 appos itself,tag
R5768 T8357 T8351 acl binds,possibility
R5769 T8274 T8265 conj mutated,are
R5770 T8275 T8274 punct (,mutated
R5771 T8358 T8357 prep to,binds
R5772 T8276 T8274 dobj M2,mutated
R5773 T8359 T8360 det the,probe
R5774 T8360 T8358 pobj probe,to
R5775 T8361 T8366 punct ",",used
R5776 T8277 T8276 cc and,M2
R5777 T8362 T8364 det an,Sox6
R5778 T8363 T8364 amod HA-tagged,Sox6
R5779 T8364 T8366 nsubjpass Sox6,used
R5780 T8278 T8276 conj M3,M2
R5781 T8365 T8366 auxpass was,used
R5782 T8366 T8366 ROOT used,used
R5783 T8279 T8276 punct ),M2
R5784 T8367 T8366 prep in,used
R5785 T8368 T8369 det another,EMSA
R5786 T8369 T8367 pobj EMSA,in
R5787 T8280 T8274 prep in,mutated
R5788 T8370 T8371 nsubj that,confirmed
R5789 T8371 T8366 ccomp confirmed,used
R5790 T8372 T8373 det these,results
R5791 T8281 T8280 pobj Sox/Sox6,in
R5792 T8373 T8371 dobj results,confirmed
R5793 T8374 T8376 punct (,3C
R5794 T8375 T8376 compound Figure,3C
R5795 T8282 T8283 amod binding,sites
R5796 T8376 T8373 appos 3C,results
R5797 T8377 T8376 punct ),3C
R5798 T8378 T8366 punct .,used
R5799 T8283 T8280 pobj sites,in
R5800 T8379 T8382 advmod Next,extracts
R5801 T8380 T8382 punct ",",extracts
R5802 T8284 T8286 punct (,3A
R5803 T8381 T8382 amod nuclear,extracts
R5804 T8382 T8387 nsubjpass extracts,used
R5805 T8383 T8382 prep from,extracts
R5806 T8384 T8385 compound MEL,cells
R5807 T8385 T8383 pobj cells,from
R5808 T8386 T8387 auxpass were,used
R5809 T8387 T8387 ROOT used,used
R5810 T8285 T8286 compound Figure,3A
R5811 T8388 T8387 prep in,used
R5812 T8389 T8388 pobj EMSA,in
R5813 T8390 T8387 advcl employing,used
R5814 T8286 T8274 npadvmod 3A,mutated
R5815 T8391 T8394 det the,probe
R5816 T8392 T8394 amod same,probe
R5817 T8393 T8394 amod 36-bp,probe
R5818 T8287 T8263 punct ),probes
R5819 T8394 T8390 dobj probe,employing
R5820 T8395 T8387 punct .,used
R5821 T8396 T8397 compound MEL,cells
R5822 T8288 T8256 punct .,included
R5823 T8397 T8397 ROOT cells,cells
R5824 T8398 T8397 punct ",",cells
R5825 T8399 T8403 det a,line
R5826 T8289 T8290 nsubj Sox6,is
R5827 T8400 T8403 amod murine,line
R5828 T8401 T8402 compound erythroleukemic,cell
R5829 T8402 T8403 compound cell,line
R5830 T8290 T8290 ROOT is,is
R5831 T8403 T8397 appos line,cells
R5832 T8404 T8403 punct ",",line
R5833 T8405 T8408 amod express,globins
R5834 T8291 T8290 acomp able,is
R5835 T8406 T8408 compound adult,globins
R5836 T8407 T8408 compound β,globins
R5837 T8408 T8403 conj globins,line
R5838 T8292 T8294 aux to,associate
R5839 T8409 T8408 punct ",",globins
R5840 T8410 T8408 cc but,globins
R5841 T8411 T8412 neg not,ɛy
R5842 T8293 T8294 advmod physically,associate
R5843 T8412 T8408 conj ɛy,globins
R5844 T8413 T8415 nmod [,]
R5845 T8414 T8415 nummod 33,]
R5846 T8294 T8291 xcomp associate,able
R5847 T8415 T8415 ROOT ],]
R5848 T8416 T8415 punct .,]
R5849 T8417 T8419 amod Sox6,binds
R5850 T8295 T8294 prep with,associate
R5851 T8418 T8419 advmod directly,binds
R5852 T8419 T8419 ROOT binds,binds
R5853 T8420 T8419 prep to,binds
R5854 T8296 T8298 det the,region
R5855 T8421 T8423 det this,sequence
R5856 T8422 T8423 compound DNA,sequence
R5857 T8423 T8420 pobj sequence,to
R5858 T8297 T8298 amod 36-bp,region
R5859 T8298 T8295 pobj region,with
R5860 T8424 T8423 prep in,sequence
R5861 T8299 T8301 punct (,3B
R5862 T8300 T8301 compound Figure,3B
R5863 T8425 T8426 compound MEL,cells
R5864 T8301 T8298 appos 3B,region
R5865 T8426 T8424 pobj cells,in
R5866 T8302 T8298 punct ),region
R5867 T8427 T8428 punct (,Figure
R5868 T8428 T8426 appos Figure,cells
R5869 T8303 T8294 prep within,associate
R5870 T8429 T8428 nummod 3D,Figure
R5871 T8430 T8428 punct ),Figure
R5872 T8431 T8419 punct .,binds
R5873 T8304 T8306 det the,promoter
R5874 T8432 T8434 det The,consensus
R5875 T8433 T8434 amod intact,consensus
R5876 T8434 T8434 ROOT consensus,consensus
R5877 T8305 T8306 amod ɛy,promoter
R5878 T8435 T8434 appos Sox/Sox6,consensus
R5879 T8306 T8303 pobj promoter,within
R5880 T8436 T8437 amod binding,sites
R5881 T8307 T8306 acl defined,promoter
R5882 T8437 T8443 nsubjpass sites,required
R5883 T8438 T8437 prep of,sites
R5884 T8308 T8307 agent by,defined
R5885 T8439 T8441 det the,probe
R5886 T8440 T8441 compound DNA,probe
R5887 T8309 T8312 det the,experiments
R5888 T8441 T8438 pobj probe,of
R5889 T8442 T8443 auxpass are,required
R5890 T8443 T8434 relcl required,consensus
R5891 T8310 T8312 compound deletion,experiments
R5892 T8444 T8443 prep for,required
R5893 T8445 T8446 det the,binding
R5894 T8311 T8312 compound analysis,experiments
R5895 T8446 T8444 pobj binding,for
R5896 T8447 T8443 punct ",",required
R5897 T8312 T8308 pobj experiments,by
R5898 T8448 T8449 mark as,shown
R5899 T8449 T8443 advcl shown,required
R5900 T8450 T8449 prep in,shown
R5901 T8313 T8314 punct (,Figure
R5902 T8451 T8453 det the,assay
R5903 T8452 T8453 compound competition,assay
R5904 T8314 T8312 appos Figure,experiments
R5905 T8453 T8450 pobj assay,in
R5906 T8454 T8455 punct (,Figure
R5907 T8455 T8453 appos Figure,assay
R5908 T8456 T8455 nummod 3E,Figure
R5909 T8457 T8455 punct ),Figure
R5910 T8458 T8443 punct .,required
R5911 T8459 T8470 nsubj Ablation,abolish
R5912 T8315 T8314 nummod 2C,Figure
R5913 T8460 T8459 prep of,Ablation
R5914 T8461 T8464 amod putative,sites
R5915 T8462 T8464 nmod Sox/Sox6,sites
R5916 T8316 T8314 punct ),Figure
R5917 T8463 T8464 amod binding,sites
R5918 T8464 T8460 pobj sites,of
R5919 T8317 T8290 punct .,is
R5920 T8465 T8464 punct (,sites
R5921 T8466 T8464 appos M1,sites
R5922 T8467 T8466 cc and,M1
R5923 T8468 T8466 conj M3,M1
R5924 T8318 T8320 det The,probe
R5925 T8469 T8464 punct ),sites
R5926 T8470 T8470 ROOT abolish,abolish
R5927 T8319 T8320 compound 36-bp,probe
R5928 T8471 T8472 poss their,ability
R5929 T8472 T8470 dobj ability,abolish
R5930 T8473 T8474 aux to,compete
R5931 T8320 T8322 nsubjpass probe,shifted
R5932 T8474 T8472 acl compete,ability
R5933 T8475 T8474 prep in,compete
R5934 T8476 T8475 pobj EMSA,in
R5935 T8321 T8322 auxpass was,shifted
R5936 T8477 T8479 punct (,3E
R5937 T8478 T8479 compound Figure,3E
R5938 T8479 T8476 appos 3E,EMSA
R5939 T8322 T8322 ROOT shifted,shifted
R5940 T8480 T8479 punct ),3E
R5941 T8481 T8470 punct .,abolish
R5942 T8482 T8485 det The,probe
R5943 T8323 T8322 agent by,shifted
R5944 T8483 T8485 compound M2,probe
R5945 T8484 T8485 amod mutant,probe
R5946 T8485 T8487 nsubj probe,compete
R5947 T8324 T8327 det the,protein
R5948 T8486 T8487 aux may,compete
R5949 T8487 T8487 ROOT compete,compete
R5950 T8488 T8487 advmod partially,compete
R5951 T8325 T8327 amod tagged,protein
R5952 T8489 T8487 prep with,compete
R5953 T8490 T8489 pobj WT,with
R5954 T8491 T8487 advcl binding,compete
R5955 T8326 T8327 compound Sox6,protein
R5956 T8492 T8487 punct .,compete
R5957 T8493 T8494 aux To,investigate
R5958 T8494 T8516 advcl investigate,co-transfected
R5959 T8495 T8497 det the,significance
R5960 T8496 T8497 amod functional,significance
R5961 T8497 T8494 dobj significance,investigate
R5962 T8521 T8517 pobj vector,with
R5963 T8498 T8497 prep of,significance
R5964 T8499 T8503 det the,sites
R5965 T8500 T8503 amod intact,sites
R5966 T8522 T8521 prep into,vector
R5967 T8501 T8503 nmod Sox/Sox6,sites
R5968 T8502 T8503 amod binding,sites
R5969 T8503 T8498 pobj sites,of
R5970 T8523 T8524 compound GM979,cells
R5971 T8504 T8503 punct ",",sites
R5972 T8505 T8508 det the,reporter
R5973 T8506 T8508 amod ɛy,reporter
R5974 T8524 T8522 pobj cells,into
R5975 T8507 T8508 compound promoter,reporter
R5976 T8508 T8509 nsubj reporter,constructs
R5977 T8509 T8494 dobj constructs,investigate
R5978 T8525 T8516 punct .,co-transfected
R5979 T8510 T8509 prep with,constructs
R5980 T8511 T8512 compound mutagenized,Sox/Sox6
R5981 T8512 T8514 nmod Sox/Sox6,sites
R5982 T8526 T8537 advmod Consistent,constructs
R5983 T8513 T8514 amod binding,sites
R5984 T8514 T8510 pobj sites,with
R5985 T8527 T8526 prep with,Consistent
R5986 T8515 T8516 auxpass were,co-transfected
R5987 T8528 T8530 det the,results
R5988 T8516 T8516 ROOT co-transfected,co-transfected
R5989 T8517 T8516 prep with,co-transfected
R5990 T8529 T8530 compound EMSA,results
R5991 T8518 T8521 det the,vector
R5992 T8519 T8521 amod Sox6,vector
R5993 T8520 T8521 compound overexpression,vector
R5994 T8530 T8527 pobj results,with
R5995 T8531 T8537 punct ",",constructs
R5996 T8532 T8536 det the,reporter
R5997 T8533 T8536 amod mutant,reporter
R5998 T8534 T8536 compound ɛy,reporter
R5999 T8618 T8619 compound liver,cells
R6000 T8535 T8536 compound promoter,reporter
R6001 T8619 T8617 pobj cells,from
R6002 T8620 T8619 prep of,cells
R6003 T8536 T8537 nsubj reporter,constructs
R6004 T8621 T8624 nummod 15.5,mice
R6005 T8622 T8623 compound dpc,WT
R6006 T8537 T8551 nsubj constructs,result
R6007 T8623 T8624 compound WT,mice
R6008 T8624 T8620 pobj mice,of
R6009 T8625 T8612 advcl using,immunoprecipitated
R6010 T8626 T8627 amod Sox6,antibody
R6011 T8627 T8625 dobj antibody,using
R6012 T8628 T8612 punct .,immunoprecipitated
R6013 T8629 T8631 nsubj Figure,shows
R6014 T8538 T8539 punct (,with
R6015 T8630 T8629 nummod 4,Figure
R6016 T8631 T8631 ROOT shows,shows
R6017 T8539 T8537 prep with,constructs
R6018 T8632 T8639 mark that,immunoprecipitated
R6019 T8633 T8636 det the,promoter
R6020 T8540 T8541 det either,one
R6021 T8634 T8636 amod ɛy,promoter
R6022 T8635 T8636 amod proximal,promoter
R6023 T8541 T8539 pobj one,with
R6024 T8636 T8639 nsubjpass promoter,immunoprecipitated
R6025 T8637 T8639 auxpass is,immunoprecipitated
R6026 T8638 T8639 advmod readily,immunoprecipitated
R6027 T8542 T8541 cc or,one
R6028 T8639 T8631 ccomp immunoprecipitated,shows
R6029 T8640 T8639 prep with,immunoprecipitated
R6030 T8641 T8642 amod Sox6,antibody
R6031 T8543 T8546 det both,sites
R6032 T8642 T8640 pobj antibody,with
R6033 T8643 T8639 prep in,immunoprecipitated
R6034 T8644 T8646 det both,cells
R6035 T8544 T8546 amod Sox/Sox6,sites
R6036 T8645 T8646 compound MEL,cells
R6037 T8646 T8643 pobj cells,in
R6038 T8545 T8546 amod binding,sites
R6039 T8647 T8646 cc and,cells
R6040 T8648 T8649 compound liver,cells
R6041 T8649 T8646 conj cells,cells
R6042 T8650 T8631 punct .,shows
R6043 T8546 T8541 conj sites,one
R6044 T8651 T8652 compound Normal,IgG
R6045 T8652 T8654 nsubjpass IgG,used
R6046 T8547 T8541 amod mutagenized,one
R6047 T8653 T8654 auxpass was,used
R6048 T8654 T8654 ROOT used,used
R6049 T8655 T8654 prep as,used
R6050 T8548 T8539 punct ),with
R6051 T8656 T8658 det a,control
R6052 T8657 T8658 amod negative,control
R6053 T8658 T8655 pobj control,as
R6054 T8549 T8551 aux do,result
R6055 T8659 T8661 punct (,4A
R6056 T8660 T8661 compound Figure,4A
R6057 T8661 T8658 appos 4A,control
R6058 T8662 T8661 punct ),4A
R6059 T8663 T8654 punct .,used
R6060 T8664 T8666 det The,data
R6061 T8665 T8666 amod above,data
R6062 T8550 T8551 neg not,result
R6063 T8666 T8674 nsubj data,indicate
R6064 T8667 T8668 punct (,Figures
R6065 T8551 T8551 ROOT result,result
R6066 T8668 T8674 nsubj Figures,indicate
R6067 T8669 T8668 nummod 3,Figures
R6068 T8670 T8669 cc and,3
R6069 T8671 T8668 appos 4,Figures
R6070 T8552 T8551 prep in,result
R6071 T8553 T8555 amod significant,repression
R6072 T8672 T8668 punct ),Figures
R6073 T8673 T8674 advmod clearly,indicate
R6074 T8554 T8555 compound promoter,repression
R6075 T8674 T8674 ROOT indicate,indicate
R6076 T8675 T8687 mark that,binding
R6077 T8676 T8677 amod Sox6,acts
R6078 T8555 T8552 pobj repression,in
R6079 T8677 T8687 nsubj acts,binding
R6080 T8678 T8677 prep as,acts
R6081 T8556 T8555 prep in,repression
R6082 T8679 T8680 det a,repressor
R6083 T8680 T8678 pobj repressor,as
R6084 T8681 T8680 prep of,repressor
R6085 T8557 T8558 compound transfection,studies
R6086 T8682 T8684 det the,gene
R6087 T8683 T8684 compound ɛy,gene
R6088 T8684 T8681 pobj gene,of
R6089 T8558 T8556 pobj studies,in
R6090 T8685 T8677 prep by,acts
R6091 T8686 T8687 advmod directly,binding
R6092 T8687 T8674 ccomp binding,indicate
R6093 T8559 T8560 punct (,Figure
R6094 T8688 T8687 prep to,binding
R6095 T8689 T8691 det the,promoter
R6096 T8560 T8558 appos Figure,studies
R6097 T8690 T8691 amod ɛy,promoter
R6098 T8691 T8688 pobj promoter,to
R6099 T8692 T8674 punct ",",indicate
R6100 T8561 T8560 nummod 3F,Figure
R6101 T8693 T8694 advmod probably,as
R6102 T8694 T8674 prep as,indicate
R6103 T8695 T8696 det a,dimer
R6104 T8562 T8560 punct ),Figure
R6105 T8696 T8694 pobj dimer,as
R6106 T8697 T8674 punct .,indicate
R6107 T8563 T8551 punct .,result
R6108 T8564 T8569 advmod Thus,required
R6109 T8565 T8569 punct ",",required
R6110 T8566 T8567 det both,sites
R6111 T8567 T8569 nsubjpass sites,required
R6112 T8568 T8569 auxpass are,required
R6113 T8569 T8569 ROOT required,required
R6114 T8570 T8569 prep for,required
R6115 T8571 T8572 amod maximal,repression
R6116 T8572 T8570 pobj repression,for
R6119 T8573 T8572 prep of,repression
R6120 T8574 T8573 pobj ɛy,of
R6122 T8575 T8569 agent by,required
R6123 T8576 T8575 pobj Sox6,by
R6124 T8577 T8569 punct ",",required
R6126 T8578 T8569 cc but,required
R6127 T8579 T8580 neg not,to
R6129 T8580 T8569 xcomp to,required
R6131 T8581 T8583 det the,degree
R6133 T8582 T8583 amod same,degree
R6136 T8583 T8580 pobj degree,to
R6139 T8584 T8569 punct .,required
R6141 T8585 T8587 nsubj We,tested
R6142 T8586 T8587 advmod also,tested
R6143 T8587 T8587 ROOT tested,tested
R6145 T8588 T8590 nmod whether,binds
R6146 T8589 T8590 amod Sox6,binds
R6149 T8590 T8587 dobj binds,tested
R6151 T8591 T8590 prep to,binds
R6152 T8592 T8594 det the,promoter
R6153 T8593 T8594 amod ɛy,promoter
R6154 T8594 T8591 pobj promoter,to
R6157 T8595 T8594 prep in,promoter
R6159 T8596 T8595 pobj vivo,in
R6160 T8597 T8590 acl using,binds
R6161 T8598 T8599 compound chromatin,immunoprecipitation
R6162 T8599 T8597 dobj immunoprecipitation,using
R6163 T8600 T8599 punct (,immunoprecipitation
R6164 T8601 T8599 appos ChIP,immunoprecipitation
R6165 T8602 T8599 punct ),immunoprecipitation
R6166 T8603 T8604 punct (,Figure
R6167 T8604 T8590 appos Figure,binds
R6169 T8605 T8604 nummod 4,Figure
R6171 T8606 T8604 punct ),Figure
R6172 T8607 T8587 punct .,tested
R6174 T8608 T8610 det The,complex
R6175 T8609 T8610 amod Sox6-containing,complex
R6176 T8610 T8612 nsubjpass complex,immunoprecipitated
R6179 T8611 T8612 auxpass was,immunoprecipitated
R6180 T8612 T8612 ROOT immunoprecipitated,immunoprecipitated
R6182 T8613 T8612 prep from,immunoprecipitated
R6183 T8614 T8615 compound MEL,cells
R6184 T8615 T8613 pobj cells,from
R6185 T8616 T8613 cc or,from
R6189 T8617 T8613 conj from,from
R6518 T9421 T9423 det The,Expression
R6519 T9422 T9423 compound Persistent,Expression
R6520 T9423 T9423 ROOT Expression,Expression
R6521 T9424 T9423 prep of,Expression
R6522 T9425 T9426 compound ɛy,Globin
R6523 T9426 T9424 pobj Globin,of
R6524 T9427 T9423 prep in,Expression
R6525 T9428 T9427 pobj Sox6-Deficient,in
R6526 T9429 T9430 nsubj Mice,Is
R6527 T9430 T9430 ROOT Is,Is
R6528 T9431 T9430 acomp Due,Is
R6529 T9432 T9431 prep to,Due
R6530 T9433 T9434 det a,Defect
R6531 T9434 T9432 pobj Defect,to
R6532 T9435 T9434 prep in,Defect
R6533 T9436 T9437 det the,ɛy-Gene
R6534 T9437 T9435 pobj ɛy-Gene,in
R6535 T9438 T9431 xcomp Silencing,Due
R6536 T9439 T9438 dobj Mechanism,Silencing
R6537 T9440 T9438 prep in,Silencing
R6538 T9441 T9444 compound Definitive,Normally
R6539 T9442 T9444 compound Erythroid,Normally
R6540 T9443 T9444 compound Cells,Normally
R6541 T9444 T9440 pobj Normally,in
R6542 T9445 T9452 punct ",",expressed
R6543 T9446 T9449 det the,gene
R6544 T9447 T9449 amod ɛy,gene
R6545 T9448 T9449 compound globin,gene
R6546 T9449 T9452 nsubjpass gene,expressed
R6547 T9450 T9452 auxpass is,expressed
R6548 T9451 T9452 advmod exclusively,expressed
R6549 T9452 T9430 ccomp expressed,Is
R6550 T9453 T9452 prep in,expressed
R6551 T9454 T9455 amod primitive,erythrocytes
R6552 T9455 T9453 pobj erythrocytes,in
R6553 T9456 T9452 cc and,expressed
R6554 T9457 T9452 conj silenced,expressed
R6555 T9458 T9457 prep in,silenced
R6556 T9459 T9460 amod definitive,erythrocytes
R6557 T9460 T9458 pobj erythrocytes,in
R6558 T9461 T9452 punct .,expressed
R6559 T9462 T9463 aux To,determine
R6560 T9463 T9463 ROOT determine,determine
R6561 T9464 T9471 mark whether,is
R6562 T9465 T9467 det the,expression
R6563 T9466 T9467 amod persistent,expression
R6564 T9467 T9471 nsubj expression,is
R6565 T9468 T9467 prep of,expression
R6566 T9469 T9470 amod ɛy,globin
R6567 T9470 T9468 pobj globin,of
R6568 T9471 T9463 ccomp is,determine
R6569 T9472 T9471 acomp due,is
R6570 T9473 T9472 prep to,due
R6571 T9474 T9476 amod residual,erythrocytes
R6572 T9475 T9476 amod primitive,erythrocytes
R6573 T9476 T9473 pobj erythrocytes,to
R6574 T9477 T9471 cc or,is
R6575 T9478 T9471 conj is,is
R6576 T9479 T9478 acomp due,is
R6577 T9480 T9479 prep to,due
R6578 T9481 T9482 amod ectopic,expression
R6579 T9482 T9480 pobj expression,to
R6580 T9483 T9482 prep of,expression
R6581 T9484 T9485 amod ɛy,globin
R6582 T9485 T9483 pobj globin,of
R6583 T9486 T9479 prep in,due
R6584 T9487 T9488 amod definitive,erythrocytes
R6585 T9488 T9486 pobj erythrocytes,in
R6586 T9489 T9491 punct ",",examined
R6587 T9490 T9491 nsubj we,examined
R6588 T9491 T9478 ccomp examined,is
R6589 T9492 T9494 det the,pattern
R6590 T9493 T9494 amod spatial,pattern
R6591 T9494 T9491 dobj pattern,examined
R6592 T9495 T9494 prep of,pattern
R6593 T9496 T9498 amod ɛy,transcripts
R6594 T9497 T9498 compound globin,transcripts
R6595 T9498 T9495 pobj transcripts,of
R6596 T9499 T9491 prep in,examined
R6597 T9500 T9501 compound mouse,embryos
R6598 T9501 T9499 pobj embryos,in
R6599 T9502 T9491 prep by,examined
R6600 T9503 T9491 prep in,examined
R6601 T9504 T9505 compound situ,hybridization
R6602 T9505 T9503 pobj hybridization,in
R6603 T9506 T9507 punct (,Figure
R6604 T9507 T9491 parataxis Figure,examined
R6605 T9508 T9507 nummod 5,Figure
R6606 T9509 T9507 punct ),Figure
R6607 T9510 T9463 punct .,determine
R6608 T9511 T9512 mark As,expected
R6609 T9512 T9518 advcl expected,expressed
R6610 T9513 T9518 punct ",",expressed
R6611 T9514 T9515 amod ɛy,globin
R6612 T9515 T9518 nsubjpass globin,expressed
R6613 T9516 T9518 auxpass is,expressed
R6614 T9517 T9518 neg not,expressed
R6615 T9518 T9518 ROOT expressed,expressed
R6616 T9519 T9518 prep in,expressed
R6617 T9520 T9523 det the,liver
R6618 T9521 T9523 nmod WT,liver
R6619 T9522 T9523 amod 14.5-dpc,liver
R6620 T9523 T9519 pobj liver,in
R6621 T9524 T9523 punct ",",liver
R6622 T9525 T9526 det the,site
R6623 T9526 T9523 appos site,liver
R6624 T9527 T9526 prep of,site
R6625 T9528 T9529 amod definitive,erythropoiesis
R6626 T9529 T9527 pobj erythropoiesis,of
R6627 T9530 T9526 prep in,site
R6628 T9531 T9532 det the,fetus
R6629 T9532 T9530 pobj fetus,in
R6630 T9533 T9518 punct .,expressed
R6631 T9534 T9543 prep In,seen
R6632 T9535 T9534 pobj contrast,In
R6633 T9536 T9543 punct ",",seen
R6634 T9537 T9541 amod abundant,expression
R6635 T9538 T9539 amod ectopic,ɛy
R6636 T9539 T9541 compound ɛy,expression
R6637 T9540 T9541 compound mRNA,expression
R6638 T9541 T9543 nsubjpass expression,seen
R6639 T9542 T9543 auxpass is,seen
R6640 T9543 T9543 ROOT seen,seen
R6641 T9544 T9543 prep in,seen
R6642 T9545 T9546 det the,liver
R6643 T9546 T9544 pobj liver,in
R6644 T9547 T9546 prep of,liver
R6645 T9548 T9549 amod 14.5-dpc,mutants
R6646 T9549 T9547 pobj mutants,of
R6647 T9550 T9551 punct (,Figure
R6648 T9551 T9543 dobj Figure,seen
R6649 T9552 T9551 nummod 5,Figure
R6650 T9553 T9551 appos A,Figure
R6651 T9554 T9553 appos D,A
R6652 T9555 T9551 punct ),Figure
R6653 T9556 T9543 punct .,seen
R6654 T9557 T9566 advmod However,is
R6655 T9558 T9566 punct ",",is
R6657 T9560 T9566 nsubj expression,is
R6658 T9561 T9560 prep of,expression
R6659 T9562 T9565 compound βmaj,globin
R6660 T9563 T9565 compound /,globin
R6661 T9564 T9565 compound min,globin
R6662 T9565 T9561 pobj globin,of
R6663 T9566 T9566 ROOT is,is
R6664 T9567 T9568 advmod equally,abundant
R6665 T9568 T9566 acomp abundant,is
R6666 T9569 T9568 prep in,abundant
R6667 T9570 T9571 preconj both,WT
R6668 T9571 T9575 nmod WT,mice
R6669 T9572 T9571 cc and,WT
R6670 T9573 T9571 conj p100H,WT
R6671 T9574 T9575 amod mutant,mice
R6672 T9575 T9569 pobj mice,in
R6673 T9576 T9577 punct (,Figure
R6674 T9577 T9575 appos Figure,mice
R6675 T9578 T9577 nummod 5,Figure
R6676 T9579 T9577 appos E,Figure
R6677 T9580 T9579 cc and,E
R6678 T9581 T9579 conj F,E
R6679 T9582 T9581 punct ),F
R6680 T9583 T9566 punct .,is
R6681 T9584 T9585 det These,data
R6682 T9585 T9586 nsubj data,demonstrate
R6683 T9586 T9586 ROOT demonstrate,demonstrate
R6684 T9587 T9594 mark that,are
R6685 T9588 T9591 det the,levels
R6686 T9589 T9591 amod persistent,levels
R6687 T9590 T9591 amod high,levels
R6688 T9591 T9594 nsubj levels,are
R6689 T9592 T9591 prep of,levels
R6690 T9593 T9592 pobj ɛy,of
R6691 T9594 T9586 ccomp are,demonstrate
R6692 T9595 T9594 acomp due,are
R6693 T9596 T9597 aux to,ectopic
R6694 T9597 T9595 xcomp ectopic,due
R6695 T9598 T9597 dobj expression,ectopic
R6696 T9599 T9597 prep in,ectopic
R6697 T9600 T9603 det the,cells
R6698 T9601 T9603 amod definitive,cells
R6699 T9602 T9603 amod erythroid,cells
R6700 T9603 T9599 pobj cells,in
R6701 T9604 T9605 nsubj that,mature
R6702 T9605 T9603 relcl mature,cells
R6703 T9606 T9605 prep in,mature
R6704 T9607 T9609 det the,liver
R6705 T9608 T9609 amod fetal,liver
R6706 T9609 T9606 pobj liver,in
R6707 T9610 T9586 punct ",",demonstrate
R6708 T9611 T9586 advcl suggesting,demonstrate
R6709 T9612 T9614 mark that,is
R6710 T9613 T9614 expl there,is
R6711 T9614 T9611 ccomp is,suggesting
R6712 T9615 T9617 det an,defect
R6713 T9616 T9617 amod intrinsic,defect
R6714 T9617 T9614 attr defect,is
R6715 T9618 T9617 prep of,defect
R6716 T9619 T9620 det the,ɛy
R6717 T9620 T9618 pobj ɛy,of
R6718 T9621 T9617 acl silencing,defect
R6719 T9622 T9621 dobj mechanism,silencing
R6720 T9623 T9621 prep in,silencing
R6721 T9624 T9625 amod Sox6-null,mice
R6722 T9625 T9623 pobj mice,in
R6723 T9626 T9586 punct .,demonstrate
R6969 T10094 T10096 det The,Pattern
R6970 T10095 T10096 compound Expression,Pattern
R6971 T10096 T10099 nsubj Pattern,Suggests
R6972 T10097 T10096 prep of,Pattern
R6973 T10098 T10097 pobj Sox6,of
R6974 T10099 T10099 ROOT Suggests,Suggests
R6975 T10100 T10101 det a,Role
R6976 T10101 T10099 dobj Role,Suggests
R6977 T10102 T10101 prep in,Role
R6978 T10103 T10104 amod Definitive,Erythropoiesis
R6979 T10104 T10102 pobj Erythropoiesis,in
R6980 T10105 T10106 det The,observation
R6981 T10106 T10123 nsubj observation,suggests
R6982 T10107 T10111 mark that,express
R6983 T10108 T10109 amod Sox6-deficient,mice
R6984 T10109 T10111 nsubj mice,express
R6985 T10110 T10111 advmod ectopically,express
R6986 T10111 T10106 acl express,observation
R6987 T10112 T10113 amod ɛy,globin
R6988 T10113 T10111 dobj globin,express
R6989 T10114 T10113 prep in,globin
R6990 T10115 T10114 pobj liver,in
R6991 T10116 T10115 punct ",",liver
R6992 T10117 T10121 advmod where,mature
R6993 T10118 T10120 amod definitive,cells
R6994 T10119 T10120 amod erythroid,cells
R6995 T10120 T10121 nsubj cells,mature
R6996 T10121 T10115 relcl mature,liver
R6997 T10122 T10123 punct ",",suggests
R6998 T10123 T10123 ROOT suggests,suggests
R6999 T10124 T10126 mark that,is
R7000 T10125 T10126 nsubj Sox6,is
R7001 T10126 T10123 ccomp is,suggests
R7002 T10127 T10129 det an,regulator
R7003 T10128 T10129 amod important,regulator
R7004 T10129 T10126 attr regulator,is
R7005 T10130 T10129 prep in,regulator
R7006 T10131 T10132 amod definitive,erythropoiesis
R7007 T10132 T10130 pobj erythropoiesis,in
R7008 T10133 T10123 punct .,suggests
R7009 T10134 T10135 aux To,determine
R7010 T10135 T10153 advcl determine,employed
R7011 T10136 T10141 det the,pattern
R7012 T10137 T10141 amod temporal,pattern
R7013 T10138 T10137 cc and,temporal
R7014 T10139 T10137 conj spatial,temporal
R7015 T10140 T10141 compound expression,pattern
R7016 T10141 T10135 dobj pattern,determine
R7017 T10142 T10141 prep of,pattern
R7018 T10143 T10142 pobj Sox6,of
R7019 T10144 T10143 punct ",",Sox6
R7020 T10145 T10146 compound Northern,blot
R7021 T10146 T10141 conj blot,pattern
R7022 T10147 T10146 cc and,blot
R7023 T10148 T10146 conj in,blot
R7024 T10149 T10151 compound situ,assays
R7025 T10150 T10151 compound hybridization,assays
R7026 T10151 T10148 pobj assays,in
R7027 T10152 T10153 auxpass were,employed
R7028 T10153 T10153 ROOT employed,employed
R7029 T10154 T10153 punct .,employed
R7030 T10155 T10156 mark As,shown
R7031 T10156 T10162 advcl shown,is
R7032 T10157 T10156 prep in,shown
R7033 T10158 T10157 pobj Figure,in
R7034 T10159 T10158 nummod 6A,Figure
R7035 T10160 T10162 punct ",",is
R7036 T10161 T10162 nsubj Sox6,is
R7037 T10162 T10162 ROOT is,is
R7038 T10163 T10162 acomp detectable,is
R7039 T10164 T10163 prep by,detectable
R7040 T10165 T10166 compound Northern,blot
R7041 T10166 T10164 pobj blot,by
R7042 T10167 T10162 advcl beginning,is
R7043 T10168 T10167 prep at,beginning
R7044 T10169 T10170 nummod 10.5,dpc
R7045 T10170 T10168 pobj dpc,at
R7046 T10171 T10170 punct ",",dpc
R7047 T10172 T10170 amod coincident,dpc
R7048 T10173 T10172 prep with,coincident
R7049 T10174 T10176 det the,onset
R7050 T10175 T10176 amod temporal,onset
R7051 T10176 T10173 pobj onset,with
R7052 T10177 T10176 prep of,onset
R7053 T10178 T10179 amod definitive,erythropoiesis
R7054 T10179 T10177 pobj erythropoiesis,of
R7055 T10180 T10179 prep in,erythropoiesis
R7056 T10181 T10182 det the,liver
R7057 T10182 T10180 pobj liver,in
R7058 T10183 T10162 punct .,is
R7059 T10184 T10189 advmod Furthermore,shows
R7060 T10185 T10189 punct ",",shows
R7061 T10186 T10189 prep in,shows
R7062 T10187 T10188 compound situ,hybridization
R7063 T10188 T10189 compound hybridization,shows
R7064 T10189 T10189 ROOT shows,shows
R7065 T10190 T10194 mark that,transcribed
R7066 T10191 T10194 nsubjpass Sox6,transcribed
R7067 T10192 T10194 auxpass is,transcribed
R7068 T10193 T10194 advmod highly,transcribed
R7069 T10194 T10189 ccomp transcribed,shows
R7070 T10195 T10194 prep in,transcribed
R7071 T10196 T10197 amod 12.5-dpc,liver
R7072 T10197 T10195 pobj liver,in
R7073 T10198 T10194 punct ",",transcribed
R7074 T10199 T10194 cc but,transcribed
R7075 T10200 T10201 neg not,in
R7076 T10201 T10206 prep in,at
R7077 T10202 T10203 compound yolk,sac
R7078 T10203 T10205 compound sac,islands
R7079 T10204 T10205 compound blood,islands
R7080 T10205 T10201 pobj islands,in
R7081 T10206 T10194 conj at,transcribed
R7082 T10207 T10208 nummod 7.5,dpc
R7083 T10208 T10206 pobj dpc,at
R7084 T10209 T10211 punct (,6B
R7085 T10210 T10211 compound Figure,6B
R7086 T10211 T10208 appos 6B,dpc
R7087 T10212 T10211 punct ),6B
R7088 T10213 T10189 punct .,shows
R7089 T10214 T10218 advmod Therefore,is
R7090 T10215 T10218 punct ",",is
R7091 T10216 T10217 amod Sox6,expression
R7092 T10217 T10218 nsubj expression,is
R7093 T10218 T10218 ROOT is,is
R7094 T10219 T10222 advmod temporally,coincident
R7095 T10220 T10219 cc and,temporally
R7096 T10221 T10219 conj spatially,temporally
R7097 T10222 T10218 acomp coincident,is
R7098 T10223 T10222 prep with,coincident
R7099 T10224 T10223 pobj definitive,with
R7100 T10225 T10222 punct ",",coincident
R7101 T10226 T10222 cc but,coincident
R7102 T10227 T10228 neg not,primitive
R7103 T10228 T10222 conj primitive,coincident
R7104 T10229 T10228 punct ",",primitive
R7105 T10230 T10228 conj erythropoiesis,primitive
R7106 T10231 T10218 punct .,is
R7107 T10232 T10233 det These,data
R7108 T10233 T10260 nsubj data,demonstrate
R7109 T10234 T10233 punct ",",data
R7110 T10235 T10233 acl taken,data
R7111 T10236 T10235 advmod together,taken
R7112 T10237 T10235 prep with,taken
R7113 T10238 T10239 det the,observation
R7114 T10239 T10237 pobj observation,with
R7115 T10240 T10245 mark that,expressed
R7116 T10241 T10242 amod ɛy,globin
R7117 T10242 T10245 nsubjpass globin,expressed
R7118 T10243 T10245 auxpass is,expressed
R7119 T10244 T10245 advmod highly,expressed
R7120 T10245 T10239 acl expressed,observation
R7121 T10246 T10245 prep in,expressed
R7122 T10247 T10249 det the,cells
R7123 T10248 T10249 compound liver,cells
R7124 T10249 T10246 pobj cells,in
R7125 T10250 T10249 prep of,cells
R7126 T10251 T10254 amod 14.5-dpc,mice
R7127 T10252 T10254 amod p100H,mice
R7128 T10253 T10254 amod mutant,mice
R7129 T10254 T10250 pobj mice,of
R7130 T10255 T10256 punct (,Figure
R7131 T10256 T10249 appos Figure,cells
R7132 T10257 T10256 nummod 5,Figure
R7133 T10258 T10256 punct ),Figure
R7134 T10259 T10260 punct ",",demonstrate
R7135 T10260 T10260 ROOT demonstrate,demonstrate
R7136 T10261 T10263 mark that,functions
R7137 T10262 T10263 amod Sox6,functions
R7138 T10263 T10260 ccomp functions,demonstrate
R7139 T10264 T10263 prep in,functions
R7140 T10265 T10266 amod definitive,erythropoiesis
R7141 T10266 T10264 pobj erythropoiesis,in
R7142 T10267 T10260 punct .,demonstrate
R7298 T10522 T10523 compound Mutant,p100H
R7299 T10523 T10523 ROOT p100H,p100H
R7300 T10524 T10542 nsubj Mice,noticed
R7301 T10525 T10532 preconj Have,Among
R7302 T10526 T10527 amod Higher,Numbers
R7303 T10527 T10525 dobj Numbers,Have
R7304 T10528 T10527 prep of,Numbers
R7305 T10529 T10531 compound Nucleated,Cells
R7306 T10530 T10531 compound Red,Cells
R7307 T10531 T10528 pobj Cells,of
R7308 T10532 T10542 prep Among,noticed
R7309 T10533 T10536 det the,effects
R7310 T10534 T10536 amod other,effects
R7311 T10535 T10536 amod Sox6,effects
R7312 T10536 T10532 pobj effects,Among
R7313 T10537 T10536 prep in,effects
R7314 T10538 T10537 pobj erythropoiesis,in
R7315 T10539 T10542 punct ",",noticed
R7316 T10540 T10542 nsubj we,noticed
R7317 T10541 T10542 aux have,noticed
R7318 T10542 T10542 ROOT noticed,noticed
R7319 T10543 T10545 mark that,are
R7320 T10544 T10545 expl there,are
R7321 T10545 T10542 ccomp are,noticed
R7322 T10546 T10547 advmod more,nucleated
R7323 T10547 T10550 amod nucleated,cells
R7324 T10548 T10550 amod red,cells
R7325 T10549 T10550 compound blood,cells
R7326 T10550 T10545 attr cells,are
R7327 T10551 T10550 acl circulating,cells
R7328 T10552 T10551 prep in,circulating
R7329 T10553 T10555 amod p100H,mice
R7330 T10554 T10555 amod mutant,mice
R7331 T10555 T10552 pobj mice,in
R7332 T10556 T10550 prep than,cells
R7333 T10557 T10556 prep in,than
R7334 T10558 T10559 compound WT,mice
R7335 T10559 T10557 pobj mice,in
R7336 T10560 T10545 prep at,are
R7337 T10561 T10560 pobj 14.5,at
R7338 T10562 T10569 nmod dpc,)
R7339 T10563 T10562 cc and,dpc
R7340 T10564 T10565 nummod 18.5,dpc
R7341 T10565 T10569 nmod dpc,)
R7342 T10566 T10568 punct (,7A
R7343 T10567 T10568 compound Figure,7A
R7344 T10568 T10565 appos 7A,dpc
R7345 T10569 T10545 punct ),are
R7346 T10570 T10542 punct .,noticed
R7347 T10571 T10581 advmod However,see
R7348 T10572 T10581 punct ",",see
R7349 T10573 T10581 prep at,see
R7350 T10574 T10575 amod postnatal,day
R7351 T10575 T10573 pobj day,at
R7352 T10576 T10575 nummod 10.5,day
R7353 T10577 T10581 punct ",",see
R7354 T10578 T10581 nsubj we,see
R7355 T10579 T10581 aux do,see
R7356 T10580 T10581 neg not,see
R7357 T10581 T10581 ROOT see,see
R7358 T10582 T10581 ccomp circulating,see
R7359 T10583 T10585 amod nucleated,cells
R7360 T10584 T10585 amod red,cells
R7361 T10585 T10582 dobj cells,circulating
R7362 T10586 T10582 prep in,circulating
R7363 T10587 T10588 det either,WT
R7364 T10588 T10586 pobj WT,in
R7365 T10589 T10588 cc or,WT
R7366 T10590 T10591 amod mutant,mice
R7367 T10591 T10588 conj mice,WT
R7368 T10592 T10582 punct ",",circulating
R7369 T10593 T10582 advcl suggesting,circulating
R7370 T10594 T10597 mark that,be
R7371 T10595 T10597 nsubj this,be
R7372 T10596 T10597 aux may,be
R7373 T10597 T10593 ccomp be,suggesting
R7374 T10598 T10600 det a,effect
R7375 T10599 T10600 amod transient,effect
R7376 T10600 T10597 attr effect,be
R7377 T10601 T10581 punct .,see
R7378 T10602 T10608 prep In,shows
R7379 T10603 T10602 pobj addition,In
R7380 T10604 T10608 punct ",",shows
R7381 T10605 T10607 det the,liver
R7382 T10606 T10607 amod mutant,liver
R7383 T10607 T10608 nsubj liver,shows
R7384 T10608 T10608 ROOT shows,shows
R7385 T10609 T10611 det a,increase
R7386 T10610 T10611 amod significant,increase
R7387 T10611 T10608 dobj increase,shows
R7388 T10612 T10611 prep in,increase
R7389 T10613 T10615 amod hematopoietic,cells
R7390 T10614 T10615 compound precursor,cells
R7391 T10615 T10612 pobj cells,in
R7392 T10616 T10615 prep including,cells
R7393 T10617 T10618 amod nucleated,erythrocytes
R7394 T10618 T10616 pobj erythrocytes,including
R7395 T10619 T10618 prep at,erythrocytes
R7396 T10620 T10621 nummod 18.5,dpc
R7397 T10621 T10619 pobj dpc,at
R7398 T10622 T10624 punct (,7B
R7399 T10623 T10624 compound Figure,7B
R7400 T10624 T10621 appos 7B,dpc
R7401 T10625 T10624 punct ),7B
R7402 T10626 T10608 punct .,shows
R7403 T10627 T10628 det This,alteration
R7404 T10628 T10630 nsubjpass alteration,noted
R7405 T10629 T10630 auxpass is,noted
R7406 T10630 T10630 ROOT noted,noted
R7407 T10631 T10632 advmod as,early
R7408 T10632 T10630 advmod early,noted
R7409 T10633 T10632 prep as,early
R7410 T10634 T10635 nummod 14.5,dpc
R7411 T10635 T10633 pobj dpc,as
R7412 T10636 T10630 punct .,noted
R7413 T10637 T10638 det These,observations
R7414 T10638 T10639 nsubj observations,suggest
R7415 T10639 T10639 ROOT suggest,suggest
R7416 T10640 T10650 mark that,affect
R7417 T10641 T10650 prep besides,affect
R7418 T10642 T10641 pcomp silencing,besides
R7419 T10643 T10646 det the,gene
R7420 T10644 T10646 amod ɛy,gene
R7421 T10645 T10646 compound globin,gene
R7422 T10646 T10642 dobj gene,silencing
R7423 T10647 T10650 punct ",",affect
R7424 T10648 T10650 nsubj Sox6,affect
R7425 T10649 T10650 aux may,affect
R7426 T10650 T10639 ccomp affect,suggest
R7427 T10651 T10652 amod red,cell
R7428 T10652 T10653 compound cell,maturation
R7429 T10653 T10650 dobj maturation,affect
R7430 T10654 T10639 punct .,suggest
R6656 T9559 T9560 det the,expression
R4426 T6363 T6364 compound Transfection,Studies

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T9851 14879-14888 Gene_expression denotes expressed
T9850 14967-14971 Protein denotes Sox6
T9849 14859-14868 Protein denotes ɛy globin
T9848 14704-14714 Gene_expression denotes expression
T9847 14699-14703 Protein denotes Sox6
T9846 14599-14610 Transcription denotes transcribed
T9845 14584-14588 Protein denotes Sox6
T9844 14401-14405 Protein denotes Sox6
T9843 14288-14298 Gene_expression denotes expression
T9842 14310-14314 Protein denotes Sox6
T9841 14106-14113 Gene_expression denotes express
T9840 14079-14088 Negative_regulation denotes deficient
T9839 14189-14193 Protein denotes Sox6
T9838 14117-14123 Protein denotes globin
T9837 14074-14078 Protein denotes Sox6
T9836 13981-13991 Gene_expression denotes Expression
T9835 14003-14007 Protein denotes Sox6
T9114 13332-13336 Protein denotes Sox6
T9113 12994-13004 Gene_expression denotes expression
T9112 13052-13054 Protein denotes WT
T9111 13017-13023 Protein denotes globin
T9110 12913-12923 Gene_expression denotes expression
T9109 12905-12912 Protein denotes ɛy mRNA
T9108 12787-12796 Gene_expression denotes expressed
T9107 12770-12779 Protein denotes ɛy globin
T9106 12594-12604 Gene_expression denotes expression
T9105 12534-12537 Positive_regulation denotes due
T9104 12507-12517 Gene_expression denotes expression
T9103 12684-12702 Protein denotes globin transcripts
T9102 12611-12617 Protein denotes globin
T9101 12521-12530 Protein denotes ɛy globin
T9100 12434-12442 Positive_regulation denotes silenced
T9099 12394-12403 Gene_expression denotes expressed
T9098 12364-12378 Protein denotes ɛy globin gene
T9097 12251-12260 Negative_regulation denotes Deficient
T9096 12219-12229 Gene_expression denotes Expression
T9095 12246-12250 Protein denotes Sox6
T9094 12236-12242 Protein denotes Globin
T7371 10094-10097 Protein denotes Sox
T7370 10000-10008 Positive_regulation denotes required
T7369 10000-10008 Positive_regulation denotes required
T7368 10017-10024 Binding denotes binding
T7367 10017-10024 Binding denotes binding
T7366 9960-9964 Protein denotes Sox6
T7365 9956-9959 Protein denotes Sox
T7364 9882-9887 Binding denotes binds
T7363 9868-9872 Protein denotes Sox6
T7362 9826-9833 Gene_expression denotes express
T7361 9834-9849 Protein denotes adult β globins
T7360 9586-9591 Binding denotes binds
T7359 9619-9623 Protein denotes Sox6
T7358 9571-9574 Protein denotes Myc
T7357 9517-9521 Protein denotes Sox6
T7356 9449-9453 Protein denotes Sox6
T7355 9439-9444 Protein denotes c-Myc
T7354 9410-9414 Protein denotes Sox6
T7353 9243-9252 Binding denotes associate
T7352 9216-9220 Protein denotes Sox6
T7351 9184-9188 Protein denotes Sox6
T7350 9180-9183 Protein denotes Sox
T7349 9050-9054 Protein denotes Sox6
T7348 9046-9049 Protein denotes Sox
T7347 8646-8656 Binding denotes associated
T7346 8764-8768 Protein denotes Sox6
T7345 8629-8633 Protein denotes Sox6
T7344 8455-8459 Protein denotes Sox6
T7343 8430-8435 Binding denotes Binds
T7342 8446-8454 Entity denotes Promoter
T7341 8416-8420 Protein denotes Sox6
T5742 5395-5399 Protein denotes Sox6
T5741 5339-5342 Protein denotes HMG
T5740 5266-5273 Negative_regulation denotes abolish
T5739 5104-5112 Positive_regulation denotes required
T5738 5285-5296 Binding denotes interaction
T5737 5122-5132 Gene_expression denotes repression
T5736 5078-5089 Binding denotes interaction
T5735 5279-5284 Protein denotes CtBP2
T5734 5274-5278 Protein denotes Sox6
T5733 5199-5211 Protein denotes Sox6 protein
T5732 5117-5121 Protein denotes Sox6
T5731 5095-5100 Protein denotes CtBP2
T5730 5006-5015 Gene_expression denotes expressed
T5729 4997-5002 Protein denotes CtBP2
T5728 4939-4948 Gene_expression denotes expressed
T5727 4916-4924 Binding denotes interact
T5726 4916-4924 Binding denotes interact
T5725 4977-4995 Protein denotes fgf-3 promoter [5]
T5724 4963-4968 Protein denotes CtBP2
T5723 4867-4871 Protein denotes Sox6
T5722 3419-3423 Protein denotes Sox6
T5721 3300-3306 Entity denotes domain
T5720 3238-3252 Positive_regulation denotes overexpression
T5719 3238-3252 Gene_expression denotes overexpression
T5718 3368-3371 Protein denotes Luc
T5717 3328-3347 Protein denotes p 100H mouse allele
T5716 3296-3299 Protein denotes HMG
T5715 3268-3272 Protein denotes Sox6
T5714 3174-3184 Negative_regulation denotes repression
T5713 3082-3096 Positive_regulation denotes Overexpression
T5712 3082-3096 Gene_expression denotes Overexpression
T5711 3188-3202 Protein denotes E-Luc reporter
T5710 3100-3104 Protein denotes Sox6
T5709 2997-3021 Protein denotes luciferase reporter gene
T5708 2887-2890 Protein denotes Luc
T5707 2790-2799 Gene_expression denotes expresses
T5706 2645-2653 Entity denotes promoter
T5705 2818-2830 Protein denotes beta globins
T5704 2611-2615 Protein denotes Sox6
T5703 2530-2537 Protein denotes ɛy mRNA
T5702 2429-2437 Entity denotes Promoter
T5701 2393-2397 Protein denotes Sox6
T5749 5771-5775 Protein denotes Sox6
T5748 5767-5770 Protein denotes Sox
T5747 5713-5723 Gene_expression denotes repression
T5746 5708-5712 Protein denotes Sox6
T5745 5524-5532 Entity denotes promoter
T5744 5538-5543 Protein denotes CtBP2
T5743 5502-5506 Protein denotes Sox6
T4512 1857-1867 Gene_expression denotes expression
T4511 1918-1925 Protein denotes WT mice
T4510 1294-1304 Gene_expression denotes expression
T4509 1287-1293 Protein denotes globin
T4508 1049-1059 Gene_expression denotes expression
T4507 1069-1083 Protein denotes adult β globin
T4506 1001-1010 Protein denotes ɛy globin
T4505 441-451 Gene_expression denotes expression
T4504 441-451 Gene_expression denotes expression
T4503 484-489 Protein denotes p100H
T4502 468-480 Protein denotes globin genes
T4501 322-326 Protein denotes Sox6
T4500 133-144 Positive_regulation denotes upregulated
T4499 220-243 Protein denotes Sox6 downstream targets
T4498 90-101 Protein denotes globin gene
T4497 68-77 Negative_regulation denotes Deficient
T4496 20-30 Gene_expression denotes Expression
T4495 63-67 Protein denotes Sox6
T4494 38-54 Protein denotes Embryonic Globin
T7396 11327-11334 Binding denotes binding
T7395 11275-11279 Protein denotes Sox6
T7394 11172-11175 Protein denotes IgG
T7393 11116-11120 Protein denotes Sox6
T7392 11021-11034 Protein denotes Sox6 antibody
T7391 10913-10917 Protein denotes Sox6
T7390 10821-10826 Binding denotes binds
T7389 10837-10845 Entity denotes promoter
T7388 10816-10820 Protein denotes Sox6
T7387 10759-10763 Protein denotes Sox6
T7386 10579-10583 Protein denotes Sox6
T7385 10575-10578 Protein denotes Sox
T7384 10511-10549 Protein denotes mutant ɛy promoter reporter constructs
T7383 10428-10432 Protein denotes Sox6
T7382 10380-10384 Protein denotes Sox6
T7381 10376-10379 Protein denotes Sox
T7380 10303-10307 Protein denotes Sox6
T7379 10299-10302 Protein denotes Sox
T7378 10233-10240 Binding denotes binding
T7377 10230-10232 Protein denotes WT
T7376 10129-10136 Negative_regulation denotes abolish
T7375 10129-10136 Negative_regulation denotes abolish
T7374 10154-10161 Binding denotes compete
T7373 10154-10161 Binding denotes compete
T7372 10098-10102 Protein denotes Sox6
T10513 16710-16719 Negative_regulation denotes silencing
T10512 16740-16744 Protein denotes Sox6
T10511 16724-16738 Protein denotes ɛy globin gene
T10510 16246-16251 Protein denotes p100H
T10509 16137-16141 Protein denotes Sox6
R3938 T5701 T5702 partOf Sox6,Promoter
R3939 T5705 T5707 themeOf beta globins,expresses
R3940 T5710 T5712 themeOf Sox6,Overexpression
R3941 T5711 T5714 themeOf E-Luc reporter,repression
R3942 T5712 T5713 themeOf Overexpression,Overexpression
R3943 T5713 T5714 causeOf Overexpression,repression
R3944 T5715 T5719 themeOf Sox6,overexpression
R3945 T5716 T5721 partOf HMG,domain
R3946 T5719 T5720 themeOf overexpression,overexpression
R3947 T5723 T5726 themeOf Sox6,interact
R3948 T5723 T5727 themeOf Sox6,interact
R3949 T5724 T5726 themeOf CtBP2,interact
R3950 T5724 T5728 themeOf CtBP2,expressed
R3951 T5725 T5727 themeOf fgf-3 promoter [5],interact
R3952 T5729 T5730 themeOf CtBP2,expressed
R3953 T5731 T5736 themeOf CtBP2,interaction
R3954 T5732 T5737 themeOf Sox6,repression
R3955 T5734 T5738 themeOf Sox6,interaction
R3956 T5735 T5738 themeOf CtBP2,interaction
R3957 T5736 T5739 causeOf interaction,required
R3958 T5737 T5739 themeOf repression,required
R3959 T5738 T5740 themeOf interaction,abolish
R3960 T5746 T5747 themeOf Sox6,repression
R4983 T7341 T7343 themeOf Sox6,Binds
R4984 T7342 T7343 Site Promoter,Binds
R4985 T7345 T7347 themeOf Sox6,associated
R4986 T7352 T7353 themeOf Sox6,associate
R4987 T7358 T7360 themeOf Myc,binds
R4988 T7361 T7362 themeOf adult β globins,express
R4989 T7363 T7364 themeOf Sox6,binds
R4990 T7365 T7367 themeOf Sox,binding
R4991 T7366 T7368 themeOf Sox6,binding
R4992 T7367 T7369 themeOf binding,required
R4993 T7368 T7370 themeOf binding,required
R4994 T7371 T7373 themeOf Sox,compete
R4995 T7372 T7374 themeOf Sox6,compete
R4996 T7373 T7375 themeOf compete,abolish
R4997 T7374 T7376 themeOf compete,abolish
R4998 T7377 T7378 themeOf WT,binding
R4999 T7388 T7390 themeOf Sox6,binds
R5000 T7389 T7390 Site promoter,binds
R5001 T7395 T7396 themeOf Sox6,binding
R6263 T9095 T9097 themeOf Sox6,Deficient
R6264 T9098 T9099 themeOf ɛy globin gene,expressed
R6265 T9098 T9100 themeOf ɛy globin gene,silenced
R6266 T9101 T9104 themeOf ɛy globin,expression
R6267 T9102 T9106 themeOf globin,expression
R6268 T9104 T9105 themeOf expression,due
R6269 T9107 T9108 themeOf ɛy globin,expressed
R6270 T9109 T9110 themeOf ɛy mRNA,expression
R6271 T9111 T9113 themeOf globin,expression
R6774 T9835 T9836 themeOf Sox6,Expression
R6775 T9837 T9840 themeOf Sox6,deficient
R6776 T9838 T9841 themeOf globin,express
R6777 T9842 T9843 themeOf Sox6,expression
R6778 T9845 T9846 themeOf Sox6,transcribed
R6779 T9847 T9848 themeOf Sox6,expression
R6780 T9849 T9851 themeOf ɛy globin,expressed
R7294 T10511 T10513 themeOf ɛy globin gene,silencing
R3091 T4494 T4496 themeOf Embryonic Globin,Expression
R3092 T4495 T4497 themeOf Sox6,Deficient
R3093 T4498 T4500 themeOf globin gene,upregulated
R3094 T4502 T4504 themeOf globin genes,expression
R3095 T4503 T4505 themeOf p100H,expression
R3096 T4507 T4508 themeOf adult β globin,expression
R3097 T4509 T4510 themeOf globin,expression
R3098 T4511 T4512 themeOf WT mice,expression
R6262 T9094 T9096 themeOf Globin,Expression

testone

Id Subject Object Predicate Lexical cue
T10338 16710-16719 Negative_regulation denotes silencing
T10337 16740-16744 Protein denotes Sox6
T10336 16724-16733 Protein denotes ɛy globin
T10335 16137-16141 Protein denotes Sox6
T9750 14879-14888 Gene_expression denotes expressed
T9749 14704-14714 Gene_expression denotes expression
T9748 14106-14113 Gene_expression denotes express
T9747 14079-14088 Negative_regulation denotes deficient
T9746 14967-14971 Protein denotes Sox6
T9745 14859-14868 Protein denotes ɛy globin
T9744 14699-14703 Protein denotes Sox6
T9743 14584-14588 Protein denotes Sox6
T9742 14401-14405 Protein denotes Sox6
T9741 14310-14314 Protein denotes Sox6
T9740 14189-14193 Protein denotes Sox6
T9739 14114-14123 Protein denotes ɛy globin
T9738 14074-14078 Protein denotes Sox6
T9737 14003-14007 Protein denotes Sox6
T8982 13292-13298 Negative_regulation denotes defect
T8981 12994-13004 Gene_expression denotes expression
T8980 12908-12912 Transcription denotes mRNA
T8979 12787-12796 Gene_expression denotes expressed
T8978 12507-12517 Gene_expression denotes expression
T8977 12394-12403 Gene_expression denotes expressed
T8976 12251-12260 Negative_regulation denotes Deficient
T8975 12219-12229 Gene_expression denotes Expression
T8974 13332-13336 Protein denotes Sox6
T8973 13306-13308 Protein denotes ɛy
T8972 13155-13157 Protein denotes ɛy
T8971 13013-13023 Protein denotes min globin
T8970 13008-13012 Protein denotes βmaj
T8969 12905-12907 Protein denotes ɛy
T8968 12770-12779 Protein denotes ɛy globin
T8967 12681-12690 Protein denotes ɛy globin
T8966 12608-12617 Protein denotes ɛy globin
T8965 12521-12530 Protein denotes ɛy globin
T8964 12364-12373 Protein denotes ɛy globin
T8963 12292-12294 Protein denotes ɛy
T8962 12246-12250 Protein denotes Sox6
T8961 12233-12242 Protein denotes ɛy Globin
T7057 11345-11353 Entity denotes promoter
T7056 11342-11344 Entity denotes ɛy
T7055 11327-11334 Binding denotes binding
T7054 10837-10845 Entity denotes promoter
T7053 10821-10826 Binding denotes binds
T7052 10233-10240 Binding denotes binding
T7051 10017-10024 Binding denotes binding
T7050 10000-10008 Positive_regulation denotes required
T7049 9882-9887 Binding denotes binds
T7048 9826-9833 Gene_expression denotes express
T7047 9586-9591 Binding denotes binds
T7046 9506-9513 Binding denotes binding
T7045 9265-9267 Entity denotes bp
T7044 9262-9264 Entity denotes 36
T7043 9243-9252 Binding denotes associate
T7042 8646-8656 Binding denotes associated
T7041 8579-8588 Regulation denotes affecting
T7040 8466-8473 Negative_regulation denotes repress
T7039 8446-8454 Entity denotes Promoter
T7038 8430-8435 Binding denotes Binds
T7037 11342-11344 Protein denotes ɛy
T7036 11307-11309 Protein denotes ɛy
T7035 11275-11279 Protein denotes Sox6
T7034 11116-11120 Protein denotes Sox6
T7033 11060-11062 Protein denotes ɛy
T7032 11021-11025 Protein denotes Sox6
T7031 10913-10917 Protein denotes Sox6
T7030 10834-10836 Protein denotes ɛy
T7029 10816-10820 Protein denotes Sox6
T7028 10759-10763 Protein denotes Sox6
T7027 10753-10755 Protein denotes ɛy
T7026 10518-10520 Protein denotes ɛy
T7025 10428-10432 Protein denotes Sox6
T7024 10327-10329 Protein denotes ɛy
T7023 9868-9872 Protein denotes Sox6
T7022 9859-9861 Protein denotes ɛy
T7021 9840-9849 Protein denotes β globins
T7020 9619-9623 Protein denotes Sox6
T7019 9609-9611 Protein denotes HA
T7018 9569-9574 Protein denotes c-Myc
T7017 9517-9521 Protein denotes Sox6
T7016 9449-9453 Protein denotes Sox6
T7015 9439-9444 Protein denotes c-Myc
T7014 9410-9414 Protein denotes Sox6
T7013 9298-9300 Protein denotes ɛy
T7012 9216-9220 Protein denotes Sox6
T7011 8957-8959 Protein denotes ɛy
T7010 8764-8768 Protein denotes Sox6
T7009 8751-8756 Protein denotes c-Myc
T7008 8666-8668 Protein denotes ɛy
T7007 8629-8633 Protein denotes Sox6
T7006 8593-8595 Protein denotes ɛy
T7005 8478-8480 Protein denotes ɛy
T7004 8455-8459 Protein denotes Sox6
T7003 8443-8445 Protein denotes ɛy
T7002 8416-8420 Protein denotes Sox6
T5517 5564-5572 Negative_regulation denotes Deletion
T5516 5507-5516 Negative_regulation denotes represses
T5515 5285-5296 Binding denotes interaction
T5514 5266-5273 Negative_regulation denotes abolish
T5513 5122-5132 Negative_regulation denotes repression
T5512 5078-5089 Binding denotes interaction
T5511 5006-5015 Gene_expression denotes expressed
T5510 4916-4924 Binding denotes interact
T5509 3447-3455 Entity denotes promoter
T5508 3432-3439 Negative_regulation denotes repress
T5507 2543-2558 Transcription denotes transcriptional
T5506 2407-2416 Negative_regulation denotes Represses
T5505 5708-5712 Protein denotes Sox6
T5504 5666-5668 Protein denotes ɛy
T5503 5589-5591 Protein denotes ɛy
T5502 5538-5543 Protein denotes CtBP2
T5501 5521-5523 Protein denotes ɛy
T5500 5502-5506 Protein denotes Sox6
T5499 5435-5437 Protein denotes ɛy
T5498 5395-5399 Protein denotes Sox6
T5497 5279-5284 Protein denotes CtBP2
T5496 5274-5278 Protein denotes Sox6
T5495 5199-5203 Protein denotes Sox6
T5494 5140-5142 Protein denotes ɛy
T5493 5117-5121 Protein denotes Sox6
T5492 5095-5100 Protein denotes CtBP2
T5491 4997-5002 Protein denotes CtBP2
T5490 4977-4982 Protein denotes fgf-3
T5489 4963-4968 Protein denotes CtBP2
T5488 4867-4871 Protein denotes Sox6
T5487 3444-3446 Protein denotes ɛy
T5486 3419-3423 Protein denotes Sox6
T5485 3268-3272 Protein denotes Sox6
T5484 3100-3104 Protein denotes Sox6
T5483 2997-3007 Protein denotes luciferase
T5482 2950-2952 Protein denotes ɛy
T5481 2853-2855 Protein denotes ɛy
T5480 2818-2830 Protein denotes beta globins
T5479 2805-2807 Protein denotes ɛy
T5478 2637-2639 Protein denotes ɛy
T5477 2611-2615 Protein denotes Sox6
T5476 2575-2577 Protein denotes ɛy
T5475 2530-2532 Protein denotes ɛy
T5474 2421-2423 Protein denotes ɛy
T5473 2393-2397 Protein denotes Sox6
T4390 1857-1867 Gene_expression denotes expression
T4389 1731-1741 Gene_expression denotes expression
T4388 1049-1059 Gene_expression denotes expression
T4387 824-834 Gene_expression denotes expression
T4386 697-707 Gene_expression denotes expression
T4385 606-615 Gene_expression denotes expressed
T4384 441-451 Gene_expression denotes expression
T4383 68-77 Negative_regulation denotes Deficient
T4382 20-30 Gene_expression denotes Expression
T4381 1853-1856 Protein denotes min
T4380 1848-1852 Protein denotes βmaj
T4379 1728-1730 Protein denotes ɛy
T4378 1075-1083 Protein denotes β globin
T4377 1001-1010 Protein denotes ɛy globin
T4376 889-892 Protein denotes βh1
T4375 883-884 Protein denotes ζ
T4374 595-597 Protein denotes ɛy
T4373 322-326 Protein denotes Sox6
T4372 220-224 Protein denotes Sox6
T4371 87-96 Protein denotes ɛy globin
T4370 63-67 Protein denotes Sox6
T4369 56-58 Protein denotes ɛy
T4368 48-54 Protein denotes Globin
R3062 T4368 T4382 themeOf Globin,Expression
R3063 T4369 T4382 themeOf ɛy,Expression
R3064 T4370 T4383 themeOf Sox6,Deficient
R3065 T4374 T4386 themeOf ɛy,expression
R3066 T4374 T4385 themeOf ɛy,expressed
R3067 T4375 T4387 themeOf ζ,expression
R3068 T4376 T4387 themeOf βh1,expression
R3069 T4378 T4388 themeOf β globin,expression
R3070 T4379 T4389 themeOf ɛy,expression
R3071 T4380 T4390 themeOf βmaj,expression
R3072 T4381 T4390 themeOf min,expression
R3885 T5473 T5506 causeOf Sox6,Represses
R3886 T5486 T5508 causeOf Sox6,repress
R3887 T5488 T5510 themeOf Sox6,interact
R3888 T5489 T5510 themeOf CtBP2,interact
R3889 T5491 T5511 themeOf CtBP2,expressed
R3890 T5492 T5512 themeOf CtBP2,interaction
R3891 T5496 T5515 themeOf Sox6,interaction
R3892 T5497 T5515 themeOf CtBP2,interaction
R3893 T5500 T5516 causeOf Sox6,represses
R3894 T5509 T5487 partOf promoter,ɛy
R3895 T5509 T5508 themeOf promoter,repress
R3896 T5515 T5514 themeOf interaction,abolish
R4895 T7002 T7038 themeOf Sox6,Binds
R4896 T7004 T7040 causeOf Sox6,repress
R4897 T7007 T7042 themeOf Sox6,associated
R4898 T7012 T7043 themeOf Sox6,associate
R4899 T7015 T7046 themeOf c-Myc,binding
R4900 T7017 T7046 themeOf Sox6,binding
R4901 T7018 T7047 themeOf c-Myc,binds
R4902 T7019 T7047 themeOf HA,binds
R4903 T7020 T7047 themeOf Sox6,binds
R4904 T7021 T7048 themeOf β globins,express
R4905 T7022 T7048 themeOf ɛy,express
R4906 T7023 T7049 themeOf Sox6,binds
R4907 T7029 T7053 themeOf Sox6,binds
R4908 T7035 T7055 themeOf Sox6,binding
R4909 T7036 T7055 themeOf ɛy,binding
R4910 T7039 T7003 partOf Promoter,ɛy
R4911 T7039 T7038 themeOf Promoter,Binds
R4912 T7051 T7050 themeOf binding,required
R4913 T7054 T7053 themeOf promoter,binds
R4914 T7054 T7030 partOf promoter,ɛy
R4915 T7057 T7056 partOf promoter,ɛy
R4916 T7057 T7055 themeOf promoter,binding
R6226 T8961 T8975 themeOf ɛy Globin,Expression
R6227 T8962 T8976 themeOf Sox6,Deficient
R6228 T8964 T8977 themeOf ɛy globin,expressed
R6229 T8965 T8978 themeOf ɛy globin,expression
R6230 T8968 T8979 themeOf ɛy globin,expressed
R6231 T8970 T8981 themeOf βmaj,expression
R6232 T8971 T8981 themeOf min globin,expression
R6760 T9738 T9747 themeOf Sox6,deficient
R6761 T9739 T9748 themeOf ɛy globin,express
R6762 T9744 T9749 themeOf Sox6,expression
R6763 T9745 T9750 themeOf ɛy globin,expressed
R7160 T10336 T10338 themeOf ɛy globin,silencing
R7161 T10337 T10338 themeOf Sox6,silencing

test3

Id Subject Object Predicate Lexical cue
T10344 16740-16744 Protein denotes Sox6
T10343 16724-16733 Protein denotes ɛy globin
T10342 16137-16141 Protein denotes Sox6
T10341 16740-16744 Protein denotes Sox6
T10340 16724-16733 Protein denotes ɛy globin
T10339 16137-16141 Protein denotes Sox6
T9771 14967-14971 Protein denotes Sox6
T9770 14859-14868 Protein denotes ɛy globin
T9769 14704-14714 Gene_expression denotes expression
T9768 14699-14703 Protein denotes Sox6
T9767 14584-14588 Protein denotes Sox6
T9766 14401-14405 Protein denotes Sox6
T9765 14310-14314 Protein denotes Sox6
T9764 14189-14193 Protein denotes Sox6
T9763 14114-14123 Protein denotes ɛy globin
T9762 14074-14078 Protein denotes Sox6
T9761 14003-14007 Protein denotes Sox6
T9760 14967-14971 Protein denotes Sox6
T9759 14859-14868 Protein denotes ɛy globin
T9758 14699-14703 Protein denotes Sox6
T9757 14584-14588 Protein denotes Sox6
T9756 14401-14405 Protein denotes Sox6
T9755 14310-14314 Protein denotes Sox6
T9754 14189-14193 Protein denotes Sox6
T9753 14114-14123 Protein denotes ɛy globin
T9752 14074-14078 Protein denotes Sox6
T9751 14003-14007 Protein denotes Sox6
T9019 13332-13336 Protein denotes Sox6
T9018 13306-13308 Protein denotes ɛy
T9017 13155-13157 Protein denotes ɛy
T9016 13013-13023 Protein denotes min globin
T9015 13008-13012 Protein denotes βmaj
T9014 12994-13004 Gene_expression denotes expression
T9013 12908-12923 Transcription denotes mRNA expression
T9012 12905-12907 Protein denotes ɛy
T9011 12787-12796 Gene_expression denotes expressed
T9010 12770-12779 Protein denotes ɛy globin
T9009 12681-12690 Protein denotes ɛy globin
T9008 12608-12617 Protein denotes ɛy globin
T9007 12594-12604 Gene_expression denotes expression
T9006 12579-12582 Positive_regulation denotes due
T9005 12521-12530 Protein denotes ɛy globin
T9004 12507-12517 Gene_expression denotes expression
T9003 12394-12403 Gene_expression denotes expressed
T9002 12364-12373 Protein denotes ɛy globin
T9001 12292-12294 Protein denotes ɛy
T9000 12251-12260 Negative_regulation denotes Deficient
T8999 12246-12250 Protein denotes Sox6
T8998 12233-12242 Protein denotes ɛy Globin
T8997 12219-12229 Gene_expression denotes Expression
T8996 13332-13336 Protein denotes Sox6
T8995 13306-13308 Protein denotes ɛy
T8994 13155-13157 Protein denotes ɛy
T8993 13013-13023 Protein denotes min globin
T8992 13008-13012 Protein denotes βmaj
T8991 12905-12907 Protein denotes ɛy
T8990 12770-12779 Protein denotes ɛy globin
T8989 12681-12690 Protein denotes ɛy globin
T8988 12608-12617 Protein denotes ɛy globin
T8987 12521-12530 Protein denotes ɛy globin
T8986 12364-12373 Protein denotes ɛy globin
T8985 12292-12294 Protein denotes ɛy
T8984 12246-12250 Protein denotes Sox6
T8983 12233-12242 Protein denotes ɛy Globin
T7138 11342-11344 Protein denotes ɛy
T7137 11327-11334 Binding denotes binding
T7136 11307-11309 Protein denotes ɛy
T7135 11275-11279 Protein denotes Sox6
T7134 11116-11120 Protein denotes Sox6
T7133 11060-11062 Protein denotes ɛy
T7132 11021-11025 Protein denotes Sox6
T7131 10913-10917 Protein denotes Sox6
T7130 10837-10845 Entity denotes promoter
T7129 10834-10836 Protein denotes ɛy
T7128 10821-10826 Binding denotes binds
T7127 10816-10820 Protein denotes Sox6
T7126 10759-10763 Protein denotes Sox6
T7125 10753-10755 Protein denotes ɛy
T7124 10518-10520 Protein denotes ɛy
T7123 10428-10432 Protein denotes Sox6
T7122 10327-10329 Protein denotes ɛy
T7121 9882-9887 Binding denotes binds
T7120 9868-9872 Protein denotes Sox6
T7119 9859-9861 Protein denotes ɛy
T7118 9840-9849 Protein denotes β globins
T7117 9619-9623 Protein denotes Sox6
T7116 9609-9611 Protein denotes HA
T7115 9586-9591 Binding denotes binds
T7114 9569-9574 Protein denotes c-Myc
T7113 9517-9521 Protein denotes Sox6
T7112 9506-9513 Binding denotes binding
T7111 9449-9453 Protein denotes Sox6
T7110 9439-9444 Protein denotes c-Myc
T7109 9410-9414 Protein denotes Sox6
T7108 9298-9300 Protein denotes ɛy
T7107 9216-9220 Protein denotes Sox6
T7106 8957-8959 Protein denotes ɛy
T7105 8764-8768 Protein denotes Sox6
T7104 8751-8756 Protein denotes c-Myc
T7103 8666-8668 Protein denotes ɛy
T7102 8629-8633 Protein denotes Sox6
T7101 8593-8595 Protein denotes ɛy
T7100 8579-8588 Regulation denotes affecting
T7099 8478-8480 Protein denotes ɛy
T7098 8466-8473 Negative_regulation denotes repress
T7097 8455-8459 Protein denotes Sox6
T7096 8443-8445 Protein denotes ɛy
T7095 8430-8435 Binding denotes Binds
T7094 8416-8420 Protein denotes Sox6
T7093 11342-11344 Protein denotes ɛy
T7092 11307-11309 Protein denotes ɛy
T7091 11275-11279 Protein denotes Sox6
T7090 11116-11120 Protein denotes Sox6
T7089 11060-11062 Protein denotes ɛy
T7088 11021-11025 Protein denotes Sox6
T7087 10913-10917 Protein denotes Sox6
T7086 10834-10836 Protein denotes ɛy
T7085 10816-10820 Protein denotes Sox6
T7084 10759-10763 Protein denotes Sox6
T7083 10753-10755 Protein denotes ɛy
T7082 10518-10520 Protein denotes ɛy
T7081 10428-10432 Protein denotes Sox6
T7080 10327-10329 Protein denotes ɛy
T7079 9868-9872 Protein denotes Sox6
T7078 9859-9861 Protein denotes ɛy
T7077 9840-9849 Protein denotes β globins
T7076 9619-9623 Protein denotes Sox6
T7075 9609-9611 Protein denotes HA
T7074 9569-9574 Protein denotes c-Myc
T7073 9517-9521 Protein denotes Sox6
T7072 9449-9453 Protein denotes Sox6
T7071 9439-9444 Protein denotes c-Myc
T7070 9410-9414 Protein denotes Sox6
T7069 9298-9300 Protein denotes ɛy
T7068 9216-9220 Protein denotes Sox6
T7067 8957-8959 Protein denotes ɛy
T7066 8764-8768 Protein denotes Sox6
T7065 8751-8756 Protein denotes c-Myc
T7064 8666-8668 Protein denotes ɛy
T7063 8629-8633 Protein denotes Sox6
T7062 8593-8595 Protein denotes ɛy
T7061 8478-8480 Protein denotes ɛy
T7060 8455-8459 Protein denotes Sox6
T7059 8443-8445 Protein denotes ɛy
T7058 8416-8420 Protein denotes Sox6
T5591 5708-5712 Protein denotes Sox6
T5590 5666-5668 Protein denotes ɛy
T5589 5589-5591 Protein denotes ɛy
T5588 5538-5543 Protein denotes CtBP2
T5587 5521-5523 Protein denotes ɛy
T5586 5502-5506 Protein denotes Sox6
T5585 5435-5437 Protein denotes ɛy
T5584 5395-5399 Protein denotes Sox6
T5583 5285-5296 Binding denotes interaction
T5582 5279-5284 Protein denotes CtBP2
T5581 5274-5278 Protein denotes Sox6
T5580 5199-5203 Protein denotes Sox6
T5579 5140-5142 Protein denotes ɛy
T5578 5122-5132 Negative_regulation denotes repression
T5577 5117-5121 Protein denotes Sox6
T5576 5104-5112 Positive_regulation denotes required
T5575 5095-5100 Protein denotes CtBP2
T5574 5078-5089 Binding denotes interaction
T5573 5006-5015 Gene_expression denotes expressed
T5572 4997-5002 Protein denotes CtBP2
T5571 4977-4982 Protein denotes fgf-3
T5570 4963-4968 Protein denotes CtBP2
T5569 4939-4948 Gene_expression denotes expressed
T5568 4867-4871 Protein denotes Sox6
T5567 3444-3446 Protein denotes ɛy
T5566 3432-3439 Negative_regulation denotes repress
T5565 3419-3423 Protein denotes Sox6
T5564 3268-3272 Protein denotes Sox6
T5563 3100-3104 Protein denotes Sox6
T5562 2997-3007 Protein denotes luciferase
T5561 2950-2952 Protein denotes ɛy
T5560 2853-2855 Protein denotes ɛy
T5559 2818-2830 Protein denotes beta globins
T5558 2805-2807 Protein denotes ɛy
T5557 2637-2639 Protein denotes ɛy
T5556 2611-2615 Protein denotes Sox6
T5555 2575-2577 Protein denotes ɛy
T5554 2530-2532 Protein denotes ɛy
T5553 2421-2423 Protein denotes ɛy
T5552 2407-2416 Negative_regulation denotes Represses
T5551 2393-2397 Protein denotes Sox6
T5550 5708-5712 Protein denotes Sox6
T5549 5666-5668 Protein denotes ɛy
T5548 5589-5591 Protein denotes ɛy
T5547 5538-5543 Protein denotes CtBP2
T5546 5521-5523 Protein denotes ɛy
T5545 5502-5506 Protein denotes Sox6
T5544 5435-5437 Protein denotes ɛy
T5543 5395-5399 Protein denotes Sox6
T5542 5279-5284 Protein denotes CtBP2
T5541 5274-5278 Protein denotes Sox6
T5540 5199-5203 Protein denotes Sox6
T5539 5140-5142 Protein denotes ɛy
T5538 5117-5121 Protein denotes Sox6
T5537 5095-5100 Protein denotes CtBP2
T5536 4997-5002 Protein denotes CtBP2
T5535 4977-4982 Protein denotes fgf-3
T5534 4963-4968 Protein denotes CtBP2
T5533 4867-4871 Protein denotes Sox6
T5532 3444-3446 Protein denotes ɛy
T5531 3419-3423 Protein denotes Sox6
T5530 3268-3272 Protein denotes Sox6
T5529 3100-3104 Protein denotes Sox6
T5528 2997-3007 Protein denotes luciferase
T5527 2950-2952 Protein denotes ɛy
T5526 2853-2855 Protein denotes ɛy
T5525 2818-2830 Protein denotes beta globins
T5524 2805-2807 Protein denotes ɛy
T5523 2637-2639 Protein denotes ɛy
T5522 2611-2615 Protein denotes Sox6
T5521 2575-2577 Protein denotes ɛy
T5520 2530-2532 Protein denotes ɛy
T5519 2421-2423 Protein denotes ɛy
T5518 2393-2397 Protein denotes Sox6
T4422 1857-1867 Gene_expression denotes expression
T4421 1853-1856 Protein denotes min
T4420 1848-1852 Protein denotes βmaj
T4419 1731-1741 Gene_expression denotes expression
T4418 1728-1730 Protein denotes ɛy
T4417 1075-1083 Protein denotes β globin
T4416 1049-1059 Gene_expression denotes expression
T4415 1001-1010 Protein denotes ɛy globin
T4414 889-892 Protein denotes βh1
T4413 883-884 Protein denotes ζ
T4412 595-597 Protein denotes ɛy
T4411 322-326 Protein denotes Sox6
T4410 220-224 Protein denotes Sox6
T4409 87-96 Protein denotes ɛy globin
T4408 68-77 Negative_regulation denotes Deficient
T4407 63-67 Protein denotes Sox6
T4406 56-58 Protein denotes ɛy
T4405 48-54 Protein denotes Globin
T4404 1853-1856 Protein denotes min
T4403 1848-1852 Protein denotes βmaj
T4402 1728-1730 Protein denotes ɛy
T4401 1075-1083 Protein denotes β globin
T4400 1001-1010 Protein denotes ɛy globin
T4399 889-892 Protein denotes βh1
T4398 883-884 Protein denotes ζ
T4397 595-597 Protein denotes ɛy
T4396 322-326 Protein denotes Sox6
T4395 220-224 Protein denotes Sox6
T4394 87-96 Protein denotes ɛy globin
T4393 63-67 Protein denotes Sox6
T4392 56-58 Protein denotes ɛy
T4391 48-54 Protein denotes Globin
R3073 T4407 T4408 themeOf Sox6,Deficient
R3074 T4417 T4416 themeOf β globin,expression
R3075 T4418 T4419 themeOf ɛy,expression
R3076 T4420 T4422 themeOf βmaj,expression
R3077 T4421 T4422 themeOf min,expression
R3897 T5551 T5552 causeOf Sox6,Represses
R3898 T5553 T5551 themeOf ɛy,Sox6
R3899 T5557 T5556 themeOf ɛy,Sox6
R3900 T5558 T5556 themeOf ɛy,Sox6
R3901 T5559 T5556 themeOf beta globins,Sox6
R3902 T5565 T5566 causeOf Sox6,repress
R3903 T5568 T5569 themeOf Sox6,expressed
R3904 T5570 T5568 themeOf CtBP2,Sox6
R3905 T5570 T5569 themeOf CtBP2,expressed
R3906 T5572 T5573 themeOf CtBP2,expressed
R3907 T5574 T5576 causeOf interaction,required
R3908 T5575 T5574 themeOf CtBP2,interaction
R3909 T5578 T5576 themeOf repression,required
R3910 T5578 T5577 themeOf repression,Sox6
R3911 T5579 T5577 themeOf ɛy,Sox6
R3912 T5581 T5583 themeOf Sox6,interaction
R3913 T5582 T5583 themeOf CtBP2,interaction
R3914 T5587 T5586 themeOf ɛy,Sox6
R3915 T5588 T5586 themeOf CtBP2,Sox6
R3916 T5591 T5590 themeOf Sox6,ɛy
R4917 T7094 T7095 themeOf Sox6,Binds
R4918 T7096 T7095 themeOf ɛy,Binds
R4919 T7097 T7098 causeOf Sox6,repress
R4920 T7097 T7100 causeOf Sox6,affecting
R4921 T7099 T7097 themeOf ɛy,Sox6
R4922 T7103 T7102 themeOf ɛy,Sox6
R4923 T7105 T7102 themeOf Sox6,Sox6
R4924 T7110 T7112 themeOf c-Myc,binding
R4925 T7111 T7112 themeOf Sox6,binding
R4926 T7113 T7112 themeOf Sox6,binding
R4927 T7114 T7115 themeOf c-Myc,binds
R4928 T7116 T7115 themeOf HA,binds
R4929 T7117 T7115 themeOf Sox6,binds
R4930 T7120 T7121 themeOf Sox6,binds
R4931 T7127 T7128 themeOf Sox6,binds
R4932 T7130 T7128 themeOf promoter,binds
R4933 T7130 T7129 partOf promoter,ɛy
R4934 T7135 T7137 themeOf Sox6,binding
R4935 T7136 T7135 themeOf ɛy,Sox6
R4936 T7136 T7137 themeOf ɛy,binding
R4937 T7138 T7137 themeOf ɛy,binding
R6233 T8998 T8997 themeOf ɛy Globin,Expression
R6234 T8999 T9000 themeOf Sox6,Deficient
R6235 T9002 T9003 themeOf ɛy globin,expressed
R6236 T9004 T9006 themeOf expression,due
R6237 T9005 T9004 themeOf ɛy globin,expression
R6238 T9008 T9007 themeOf ɛy globin,expression
R6239 T9010 T9011 themeOf ɛy globin,expressed
R6240 T9012 T9013 themeOf ɛy,mRNA expression
R6241 T9015 T9014 themeOf βmaj,expression
R6242 T9016 T9014 themeOf min globin,expression
R6764 T9768 T9769 themeOf Sox6,expression