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expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T11460","span":{"begin":394,"end":397},"obj":"Antecedent"},{"id":"T11459","span":{"begin":388,"end":389},"obj":"Antecedent"},{"id":"T11458","span":{"begin":364,"end":386},"obj":"Anaphor"}],"relations":[{"id":"R7678","pred":"boundBy","subj":"T11458","obj":"T11460"},{"id":"R7677","pred":"boundBy","subj":"T11458","obj":"T11459"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T11527","span":{"begin":828,"end":830},"obj":"Protein"},{"id":"T11526","span":{"begin":703,"end":707},"obj":"Protein"},{"id":"T11525","span":{"begin":678,"end":681},"obj":"Protein"},{"id":"T11524","span":{"begin":672,"end":673},"obj":"Protein"},{"id":"T11523","span":{"begin":639,"end":641},"obj":"Protein"},{"id":"T11522","span":{"begin":569,"end":572},"obj":"Protein"},{"id":"T11521","span":{"begin":563,"end":564},"obj":"Protein"},{"id":"T11520","span":{"begin":552,"end":561},"obj":"Protein"},{"id":"T11519","span":{"begin":480,"end":483},"obj":"Protein"},{"id":"T11518","span":{"begin":474,"end":475},"obj":"Protein"},{"id":"T11517","span":{"begin":460,"end":462},"obj":"Protein"},{"id":"T11516","span":{"begin":394,"end":397},"obj":"Protein"},{"id":"T11515","span":{"begin":388,"end":389},"obj":"Protein"},{"id":"T11514","span":{"begin":271,"end":280},"obj":"Protein"},{"id":"T11513","span":{"begin":137,"end":140},"obj":"Protein"},{"id":"T11512","span":{"begin":132,"end":136},"obj":"Protein"},{"id":"T11511","span":{"begin":48,"end":52},"obj":"Protein"},{"id":"T11510","span":{"begin":24,"end":33},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T13271","span":{"begin":703,"end":707},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T13270","span":{"begin":48,"end":52},"obj":"http://www.uniprot.org/uniprot/P35712"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"GO-BP","denotations":[{"id":"T11244","span":{"begin":760,"end":782},"obj":"http://purl.obolibrary.org/obo/GO_0043249"},{"id":"T11217","span":{"begin":742,"end":748},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11216","span":{"begin":555,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11215","span":{"begin":374,"end":380},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11214","span":{"begin":274,"end":280},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11213","span":{"begin":27,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0005344"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"GO-MF","denotations":[{"id":"T11567","span":{"begin":742,"end":748},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11566","span":{"begin":555,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11565","span":{"begin":374,"end":380},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11564","span":{"begin":274,"end":280},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11563","span":{"begin":27,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0005344"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"sentences","denotations":[{"id":"T11179","span":{"begin":683,"end":831},"obj":"Sentence"},{"id":"T11178","span":{"begin":536,"end":682},"obj":"Sentence"},{"id":"T11177","span":{"begin":455,"end":535},"obj":"Sentence"},{"id":"T11176","span":{"begin":329,"end":454},"obj":"Sentence"},{"id":"T11175","span":{"begin":222,"end":328},"obj":"Sentence"},{"id":"T11174","span":{"begin":0,"end":221},"obj":"Sentence"},{"id":"T223","span":{"begin":0,"end":221},"obj":"Sentence"},{"id":"T224","span":{"begin":222,"end":328},"obj":"Sentence"},{"id":"T225","span":{"begin":329,"end":454},"obj":"Sentence"},{"id":"T226","span":{"begin":455,"end":535},"obj":"Sentence"},{"id":"T227","span":{"begin":536,"end":682},"obj":"Sentence"},{"id":"T228","span":{"begin":683,"end":831},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"simple1","denotations":[{"id":"T11791","span":{"begin":828,"end":830},"obj":"Protein"},{"id":"T11790","span":{"begin":703,"end":707},"obj":"Protein"},{"id":"T11789","span":{"begin":678,"end":681},"obj":"Protein"},{"id":"T11788","span":{"begin":672,"end":673},"obj":"Protein"},{"id":"T11787","span":{"begin":639,"end":641},"obj":"Protein"},{"id":"T11786","span":{"begin":569,"end":572},"obj":"Protein"},{"id":"T11785","span":{"begin":563,"end":564},"obj":"Protein"},{"id":"T11784","span":{"begin":552,"end":561},"obj":"Protein"},{"id":"T11783","span":{"begin":480,"end":483},"obj":"Protein"},{"id":"T11782","span":{"begin":474,"end":475},"obj":"Protein"},{"id":"T11781","span":{"begin":460,"end":462},"obj":"Protein"},{"id":"T11780","span":{"begin":394,"end":397},"obj":"Protein"},{"id":"T11779","span":{"begin":388,"end":389},"obj":"Protein"},{"id":"T11778","span":{"begin":271,"end":280},"obj":"Protein"},{"id":"T11777","span":{"begin":137,"end":140},"obj":"Protein"},{"id":"T11776","span":{"begin":132,"end":136},"obj":"Protein"},{"id":"T11775","span":{"begin":48,"end":52},"obj":"Protein"},{"id":"T11774","span":{"begin":24,"end":33},"obj":"Protein"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T15819","span":{"begin":584,"end":594},"obj":"Gene_expression"},{"id":"T15818","span":{"begin":573,"end":580},"obj":"Negative_regulation"},{"id":"T15817","span":{"begin":645,"end":654},"obj":"Regulation"},{"id":"T15816","span":{"begin":333,"end":343},"obj":"Gene_expression"},{"id":"T15815","span":{"begin":408,"end":414},"obj":"Positive_regulation"},{"id":"T15814","span":{"begin":253,"end":263},"obj":"Gene_expression"},{"id":"T15813","span":{"begin":141,"end":151},"obj":"Gene_expression"},{"id":"T15812","span":{"begin":4,"end":14},"obj":"Gene_expression"},{"id":"T15811","span":{"begin":123,"end":128},"obj":"Negative_regulation"},{"id":"T15762","span":{"begin":828,"end":830},"obj":"Protein"},{"id":"T15761","span":{"begin":703,"end":707},"obj":"Protein"},{"id":"T15760","span":{"begin":678,"end":681},"obj":"Protein"},{"id":"T15759","span":{"begin":672,"end":673},"obj":"Protein"},{"id":"T15758","span":{"begin":639,"end":641},"obj":"Protein"},{"id":"T15757","span":{"begin":569,"end":572},"obj":"Protein"},{"id":"T15756","span":{"begin":563,"end":564},"obj":"Protein"},{"id":"T15755","span":{"begin":552,"end":561},"obj":"Protein"},{"id":"T15754","span":{"begin":480,"end":483},"obj":"Protein"},{"id":"T15753","span":{"begin":474,"end":475},"obj":"Protein"},{"id":"T15752","span":{"begin":460,"end":462},"obj":"Protein"},{"id":"T15751","span":{"begin":394,"end":397},"obj":"Protein"},{"id":"T15750","span":{"begin":388,"end":389},"obj":"Protein"},{"id":"T15749","span":{"begin":271,"end":280},"obj":"Protein"},{"id":"T15748","span":{"begin":137,"end":140},"obj":"Protein"},{"id":"T15747","span":{"begin":132,"end":136},"obj":"Protein"},{"id":"T15746","span":{"begin":48,"end":52},"obj":"Protein"},{"id":"T15745","span":{"begin":24,"end":33},"obj":"Protein"}],"relations":[{"id":"R11019","pred":"themeOf","subj":"T15759","obj":"T15817"},{"id":"R11020","pred":"themeOf","subj":"T15760","obj":"T15817"},{"id":"R11051","pred":"themeOf","subj":"T15745","obj":"T15812"},{"id":"R11052","pred":"themeOf","subj":"T15747","obj":"T15813"},{"id":"R11053","pred":"themeOf","subj":"T15748","obj":"T15813"},{"id":"R11055","pred":"themeOf","subj":"T15749","obj":"T15814"},{"id":"R11056","pred":"themeOf","subj":"T15750","obj":"T15816"},{"id":"R11058","pred":"themeOf","subj":"T15751","obj":"T15815"},{"id":"R11059","pred":"themeOf","subj":"T15813","obj":"T15811"},{"id":"R11060","pred":"themeOf","subj":"T15813","obj":"T15811"},{"id":"R11061","pred":"themeOf","subj":"T15751","obj":"T15816"},{"id":"R11062","pred":"themeOf","subj":"T15755","obj":"T15818"},{"id":"R11063","pred":"themeOf","subj":"T15755","obj":"T15819"},{"id":"R11064","pred":"themeOf","subj":"T15758","obj":"T15817"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

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expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T13479","span":{"begin":333,"end":343},"obj":"Gene_expression"},{"id":"T13478","span":{"begin":333,"end":343},"obj":"Gene_expression"},{"id":"T13477","span":{"begin":451,"end":453},"obj":"Protein"},{"id":"T13476","span":{"begin":418,"end":435},"obj":"Protein"},{"id":"T13475","span":{"begin":388,"end":397},"obj":"Protein"},{"id":"T13474","span":{"begin":374,"end":386},"obj":"Protein"},{"id":"T13473","span":{"begin":253,"end":263},"obj":"Gene_expression"},{"id":"T13472","span":{"begin":274,"end":285},"obj":"Protein"},{"id":"T13471","span":{"begin":4,"end":14},"obj":"Gene_expression"},{"id":"T13470","span":{"begin":48,"end":52},"obj":"Protein"},{"id":"T13469","span":{"begin":24,"end":33},"obj":"Protein"},{"id":"T13486","span":{"begin":742,"end":754},"obj":"Protein"},{"id":"T13485","span":{"begin":703,"end":707},"obj":"Protein"},{"id":"T13484","span":{"begin":584,"end":594},"obj":"Gene_expression"},{"id":"T13483","span":{"begin":552,"end":561},"obj":"Protein"},{"id":"T13482","span":{"begin":474,"end":483},"obj":"Protein"},{"id":"T13481","span":{"begin":344,"end":350},"obj":"Positive_regulation"},{"id":"T13480","span":{"begin":344,"end":350},"obj":"Positive_regulation"}],"relations":[{"id":"R9240","pred":"themeOf","subj":"T13469","obj":"T13471"},{"id":"R9242","pred":"themeOf","subj":"T13472","obj":"T13473"},{"id":"R9243","pred":"themeOf","subj":"T13474","obj":"T13478"},{"id":"R9244","pred":"themeOf","subj":"T13475","obj":"T13479"},{"id":"R9245","pred":"themeOf","subj":"T13478","obj":"T13480"},{"id":"R9246","pred":"themeOf","subj":"T13479","obj":"T13481"},{"id":"R9247","pred":"themeOf","subj":"T13483","obj":"T13484"}],"text":"The expression level of ɛy globin in homozygous Sox6 null mice at 15.5 dpc and 18.5 dpc is statistically equivalent to the level of βmaj/min expression in the livers of 15.5-dpc and 18.5-dpc homozygous WT mice (Figure 1). This demonstrates that ectopic expression of the ɛy globin gene is quite robust in homozygous mutant mice. The expression levels of two other embryonic globin genes (ζ and βh1) are also higher in p100H homozygotes, compared with WT. Like ɛy, levels of ζ and βh1 are dramatically higher in mutant mice at 15.5 dpc. However, unlike ɛy globin, ζ and βh1 decline in expression by day 18.5 dpc (Figure 1), suggesting that ɛy is regulated differently than ζ and βh1. It is possible that Sox6 has a general effect on embryonic globin genes (and erythrocyte maturation) in addition to a specific role in silencing ɛy."}

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