PMC:1359074 / 19249-19831 JSONTXT

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also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4). The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody. Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells. Normal IgG was used as a negative control (Figure 4A). The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T7272","span":{"begin":482,"end":486},"obj":"Protein"},{"id":"T7271","span":{"begin":323,"end":327},"obj":"Protein"},{"id":"T7270","span":{"begin":267,"end":269},"obj":"Protein"},{"id":"T7269","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T7268","span":{"begin":120,"end":124},"obj":"Protein"},{"id":"T7267","span":{"begin":41,"end":43},"obj":"Protein"},{"id":"T7266","span":{"begin":23,"end":27},"obj":"Protein"},{"id":"T7274","span":{"begin":549,"end":551},"obj":"Protein"},{"id":"T7273","span":{"begin":514,"end":516},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4). The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody. Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells. Normal IgG was used as a negative control (Figure 4A). The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T7989","span":{"begin":482,"end":486},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7988","span":{"begin":323,"end":327},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7987","span":{"begin":228,"end":232},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7986","span":{"begin":120,"end":124},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7985","span":{"begin":23,"end":27},"obj":"http://www.uniprot.org/uniprot/P35712"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4). The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody. Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells. Normal IgG was used as a negative control (Figure 4A). The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer."}

{"project":"UBERON-AE","denotations":[{"id":"T7140","span":{"begin":359,"end":364},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T7139","span":{"begin":190,"end":195},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4). The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody. Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells. Normal IgG was used as a negative control (Figure 4A). The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer."}

{"project":"GO-MF","denotations":[{"id":"T7288","span":{"begin":328,"end":336},"obj":"http://purl.obolibrary.org/obo/GO_0003823"},{"id":"T7287","span":{"begin":233,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0003823"},{"id":"T7285","span":{"begin":534,"end":541},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4). The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody. Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells. Normal IgG was used as a negative control (Figure 4A). The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer."}

{"project":"GO-CC","denotations":[{"id":"T7304","span":{"begin":67,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0000785"},{"id":"T7303","span":{"begin":365,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7302","span":{"begin":349,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7301","span":{"begin":196,"end":201},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7300","span":{"begin":176,"end":181},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7295","span":{"begin":328,"end":336},"obj":"http://purl.obolibrary.org/obo/GO_0042571"},{"id":"T7294","span":{"begin":233,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0042571"},{"id":"T7292","span":{"begin":328,"end":336},"obj":"http://purl.obolibrary.org/obo/GO_0019815"},{"id":"T7291","span":{"begin":233,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0019815"}],"text":"We also tested whether Sox6 binds to the ɛy promoter in vivo using chromatin immunoprecipitation (ChIP) (Figure 4). The Sox6-containing complex was immunoprecipitated from MEL cells or from liver cells of 15.5 dpc WT mice using Sox6 antibody. Figure 4 shows that the ɛy proximal promoter is readily immunoprecipitated with Sox6 antibody in both MEL cells and liver cells. Normal IgG was used as a negative control (Figure 4A). The above data (Figures 3 and 4) clearly indicate that Sox6 acts as a repressor of the ɛy gene by directly binding to the ɛy promoter, probably as a dimer."}

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