PMC:1359074 / 18698-19248 JSONTXT

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investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T7238","span":{"begin":333,"end":355},"obj":"Antecedent"},{"id":"T7237","span":{"begin":461,"end":471},"obj":"Anaphor"}],"relations":[{"id":"R4980","pred":"boundBy","subj":"T7237","obj":"T7238"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T7265","span":{"begin":517,"end":521},"obj":"Protein"},{"id":"T7264","span":{"begin":511,"end":513},"obj":"Protein"},{"id":"T7263","span":{"begin":276,"end":278},"obj":"Protein"},{"id":"T7262","span":{"begin":186,"end":190},"obj":"Protein"},{"id":"T7261","span":{"begin":85,"end":87},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T7984","span":{"begin":517,"end":521},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7983","span":{"begin":337,"end":341},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7982","span":{"begin":186,"end":190},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7981","span":{"begin":138,"end":142},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T7980","span":{"begin":61,"end":65},"obj":"http://www.uniprot.org/uniprot/P35712"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"GO-MF","denotations":[{"id":"T7284","span":{"begin":342,"end":349},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T7283","span":{"begin":143,"end":150},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T7282","span":{"begin":66,"end":73},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"GO-CC","denotations":[{"id":"T7299","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"sentences","denotations":[{"id":"T7160","span":{"begin":455,"end":550},"obj":"Sentence"},{"id":"T7159","span":{"begin":231,"end":454},"obj":"Sentence"},{"id":"T7158","span":{"begin":0,"end":230},"obj":"Sentence"},{"id":"T134","span":{"begin":0,"end":230},"obj":"Sentence"},{"id":"T135","span":{"begin":231,"end":454},"obj":"Sentence"},{"id":"T136","span":{"begin":455,"end":550},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"simple1","denotations":[{"id":"T7423","span":{"begin":517,"end":521},"obj":"Protein"},{"id":"T7422","span":{"begin":511,"end":513},"obj":"Protein"},{"id":"T7421","span":{"begin":276,"end":278},"obj":"Protein"},{"id":"T7420","span":{"begin":186,"end":190},"obj":"Protein"},{"id":"T7419","span":{"begin":85,"end":87},"obj":"Protein"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T8906","span":{"begin":497,"end":507},"obj":"Negative_regulation"},{"id":"T8905","span":{"begin":476,"end":484},"obj":"Positive_regulation"},{"id":"T8904","span":{"begin":191,"end":205},"obj":"Gene_expression"},{"id":"T8885","span":{"begin":517,"end":521},"obj":"Protein"},{"id":"T8884","span":{"begin":511,"end":513},"obj":"Protein"},{"id":"T8883","span":{"begin":276,"end":278},"obj":"Protein"},{"id":"T8882","span":{"begin":186,"end":190},"obj":"Protein"},{"id":"T8881","span":{"begin":85,"end":87},"obj":"Protein"}],"relations":[{"id":"R6213","pred":"themeOf","subj":"T8882","obj":"T8904"},{"id":"R6214","pred":"themeOf","subj":"T8884","obj":"T8906"},{"id":"R6215","pred":"causeOf","subj":"T8885","obj":"T8906"},{"id":"R6225","pred":"themeOf","subj":"T8906","obj":"T8905"}],"text":"To investigate the functional significance of the intact Sox/Sox6 binding sites, the ɛy promoter reporter constructs with mutagenized Sox/Sox6 binding sites were co-transfected with the Sox6 overexpression vector into GM979 cells. Consistent with the EMSA results, the mutant ɛy promoter reporter constructs (with either one or both Sox/Sox6 binding sites mutagenized) do not result in significant promoter repression in transfection studies (Figure 3F). Thus, both sites are required for maximal repression of ɛy by Sox6, but not to the same degree."}

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