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investigate whether the interaction with CtBP2 is required for Sox6 repression of the ɛy promoter, we introduced a point mutation (L386H) in the Sox6 protein that has been previously reported to be sufficient to abolish Sox6-CtBP2 interaction [5]."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T5740","span":{"begin":215,"end":222},"obj":"Negative_regulation"},{"id":"T5739","span":{"begin":53,"end":61},"obj":"Positive_regulation"},{"id":"T5738","span":{"begin":234,"end":245},"obj":"Binding"},{"id":"T5737","span":{"begin":71,"end":81},"obj":"Gene_expression"},{"id":"T5736","span":{"begin":27,"end":38},"obj":"Binding"},{"id":"T5735","span":{"begin":228,"end":233},"obj":"Protein"},{"id":"T5734","span":{"begin":223,"end":227},"obj":"Protein"},{"id":"T5733","span":{"begin":148,"end":160},"obj":"Protein"},{"id":"T5732","span":{"begin":66,"end":70},"obj":"Protein"},{"id":"T5731","span":{"begin":44,"end":49},"obj":"Protein"}],"relations":[{"id":"R3953","pred":"themeOf","subj":"T5731","obj":"T5736"},{"id":"R3954","pred":"themeOf","subj":"T5732","obj":"T5737"},{"id":"R3955","pred":"themeOf","subj":"T5734","obj":"T5738"},{"id":"R3956","pred":"themeOf","subj":"T5735","obj":"T5738"},{"id":"R3957","pred":"causeOf","subj":"T5736","obj":"T5739"},{"id":"R3958","pred":"themeOf","subj":"T5737","obj":"T5739"},{"id":"R3959","pred":"themeOf","subj":"T5738","obj":"T5740"}],"text":"To investigate whether the interaction with CtBP2 is required for Sox6 repression of the ɛy promoter, we introduced a point mutation (L386H) in the Sox6 protein that has been previously reported to be sufficient to abolish Sox6-CtBP2 interaction [5]."}

{"project":"testone","denotations":[{"id":"T5515","span":{"begin":234,"end":245},"obj":"Binding"},{"id":"T5514","span":{"begin":215,"end":222},"obj":"Negative_regulation"},{"id":"T5513","span":{"begin":71,"end":81},"obj":"Negative_regulation"},{"id":"T5512","span":{"begin":27,"end":38},"obj":"Binding"},{"id":"T5497","span":{"begin":228,"end":233},"obj":"Protein"},{"id":"T5496","span":{"begin":223,"end":227},"obj":"Protein"},{"id":"T5495","span":{"begin":148,"end":152},"obj":"Protein"},{"id":"T5494","span":{"begin":89,"end":91},"obj":"Protein"},{"id":"T5493","span":{"begin":66,"end":70},"obj":"Protein"},{"id":"T5492","span":{"begin":44,"end":49},"obj":"Protein"}],"relations":[{"id":"R3890","pred":"themeOf","subj":"T5492","obj":"T5512"},{"id":"R3891","pred":"themeOf","subj":"T5496","obj":"T5515"},{"id":"R3892","pred":"themeOf","subj":"T5497","obj":"T5515"},{"id":"R3896","pred":"themeOf","subj":"T5515","obj":"T5514"}],"text":"To investigate whether the interaction with CtBP2 is required for Sox6 repression of the ɛy promoter, we introduced a point mutation (L386H) in the Sox6 protein that has been previously reported to be sufficient to abolish Sox6-CtBP2 interaction [5]."}

{"project":"test3","denotations":[{"id":"T5583","span":{"begin":234,"end":245},"obj":"Binding"},{"id":"T5582","span":{"begin":228,"end":233},"obj":"Protein"},{"id":"T5581","span":{"begin":223,"end":227},"obj":"Protein"},{"id":"T5580","span":{"begin":148,"end":152},"obj":"Protein"},{"id":"T5579","span":{"begin":89,"end":91},"obj":"Protein"},{"id":"T5578","span":{"begin":71,"end":81},"obj":"Negative_regulation"},{"id":"T5577","span":{"begin":66,"end":70},"obj":"Protein"},{"id":"T5576","span":{"begin":53,"end":61},"obj":"Positive_regulation"},{"id":"T5575","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T5574","span":{"begin":27,"end":38},"obj":"Binding"},{"id":"T5542","span":{"begin":228,"end":233},"obj":"Protein"},{"id":"T5541","span":{"begin":223,"end":227},"obj":"Protein"},{"id":"T5540","span":{"begin":148,"end":152},"obj":"Protein"},{"id":"T5539","span":{"begin":89,"end":91},"obj":"Protein"},{"id":"T5538","span":{"begin":66,"end":70},"obj":"Protein"},{"id":"T5537","span":{"begin":44,"end":49},"obj":"Protein"}],"relations":[{"id":"R3907","pred":"causeOf","subj":"T5574","obj":"T5576"},{"id":"R3908","pred":"themeOf","subj":"T5575","obj":"T5574"},{"id":"R3909","pred":"themeOf","subj":"T5578","obj":"T5576"},{"id":"R3910","pred":"themeOf","subj":"T5578","obj":"T5577"},{"id":"R3911","pred":"themeOf","subj":"T5579","obj":"T5577"},{"id":"R3912","pred":"themeOf","subj":"T5581","obj":"T5583"},{"id":"R3913","pred":"themeOf","subj":"T5582","obj":"T5583"}],"text":"To investigate whether the interaction with CtBP2 is required for Sox6 repression of the ɛy promoter, we introduced a point mutation (L386H) in the Sox6 protein that has been previously reported to be sufficient to abolish Sox6-CtBP2 interaction [5]."}