> top > docs > PMC:1359074 > spans > 127-1433 > annotations

PMC:1359074 / 127-1433 JSONTXT

Annnotations TAB JSON ListView MergeView

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T472 1294-1305 NN denotes thalassemia
T471 1290-1293 CC denotes and
T470 1283-1289 NN denotes anemia
T469 1278-1282 NN denotes cell
T468 1271-1277 JJ denotes sickle
T467 1268-1270 IN denotes as
T466 1263-1267 JJ denotes such
T465 1244-1262 NN denotes hemoglobinopathies
T464 1241-1243 IN denotes of
T463 1231-1240 NN denotes treatment
T462 1227-1230 DT denotes the
T461 1224-1226 IN denotes in
T460 1217-1223 NN denotes target
T459 1203-1216 JJ denotes therapeutical
T458 1197-1202 JJ denotes novel
T457 1195-1196 DT denotes a
T456 1187-1194 VB denotes provide
T455 1181-1186 MD denotes might
T454 1174-1180 NN denotes globin
T453 1171-1173 JJ denotes ɛy
T452 1168-1170 IN denotes of
T451 1157-1167 NN denotes regulation
T450 1152-1156 NN denotes Sox6
T449 1150-1151 -COMMA- denotes ,
T448 1146-1150 RB denotes Thus
T447 1134-1144 NN denotes maturation
T446 1129-1133 NN denotes cell
T445 1119-1128 JJ denotes erythroid
T444 1116-1118 IN denotes in
T443 1111-1115 NN denotes Sox6
T442 1107-1110 IN denotes for
T441 1102-1106 NN denotes role
T440 1100-1101 DT denotes a
T439 1091-1099 VB denotes suggests
T438 1087-1090 CC denotes and
T437 1072-1086 NN denotes erythropoiesis
T436 1061-1071 JJ denotes definitive
T435 1058-1060 IN denotes in
T434 1051-1057 NN denotes globin
T433 1048-1050 JJ denotes ɛy
T429 1022-1030 VB denotes required
T428 1019-1021 VB denotes is
T427 1014-1018 NN denotes Sox6
T426 1009-1013 IN denotes that
T425 1003-1008 VB denotes shows
T424 997-1002 NN denotes study
T423 989-996 JJ denotes present
T422 985-988 DT denotes The
T421 969-983 NN denotes erythropoiesis
T420 958-968 JJ denotes definitive
T419 955-957 IN denotes in
T418 945-954 NN denotes functions
T417 940-944 NN denotes Sox6
T416 935-939 IN denotes that
T415 923-934 VB denotes demonstrate
T414 917-922 NN denotes liver
T413 911-916 JJ denotes fetal
T412 900-910 JJ denotes homozygous
T411 894-899 NN denotes p100H
T410 891-893 IN denotes in
T409 888-890 NN denotes ɛy
T408 885-887 IN denotes of
T407 874-884 NN denotes expression
T406 866-873 JJ denotes ectopic
T405 862-865 DT denotes the
T404 858-861 CC denotes and
T403 852-857 NN denotes liver
T402 846-851 JJ denotes fetal
T401 836-845 JJ denotes wild-type
T400 833-835 IN denotes in
T399 828-832 NN denotes Sox6
T398 825-827 IN denotes of
T397 814-824 NN denotes expression
T396 807-813 JJ denotes normal
T395 803-806 DT denotes The
T394 793-801 NN denotes promoter
T393 790-792 JJ denotes ɛy
T392 786-789 DT denotes the
T391 783-785 TO denotes to
T390 775-782 VB denotes binding
T389 766-774 RB denotes directly
T388 763-765 IN denotes by
T387 753-762 NN denotes repressor
T386 751-752 DT denotes a
T385 748-750 IN denotes as
T384 743-747 VB denotes acts
T383 738-742 NN denotes Sox6
T382 733-737 IN denotes that
T381 721-732 VB denotes demonstrate
T380 714-720 NN denotes assays
T379 712-713 -RRB- denotes )
T378 708-712 NN denotes ChIP
T377 707-708 -LRB- denotes (
T376 687-706 NN denotes immunoprecipitation
T375 677-686 NN denotes chromatin
T374 673-676 CC denotes and
T373 671-672 -RRB- denotes )
T372 667-671 NN denotes EMSA
T371 666-667 -LRB- denotes (
T370 660-665 NN denotes assay
T369 654-659 NN denotes shift
T368 645-653 NN denotes mobility
T367 629-644 JJ denotes Electrophoretic
T366 617-627 NN denotes repression
T365 608-616 VB denotes mediated
T364 603-607 NN denotes Sox6
T363 599-602 IN denotes for
T362 590-598 JJ denotes critical
T361 587-589 VB denotes is
T360 582-586 WDT denotes that
T359 573-581 NN denotes promoter
T358 564-572 JJ denotes proximal
T357 561-563 JJ denotes ɛy
T356 557-560 DT denotes the
T355 554-556 IN denotes of
T354 547-553 NN denotes region
T353 542-546 NN denotes pair
T352 534-541 NN denotes 36–base
T351 532-533 DT denotes a
T350 525-531 VB denotes define
T349 519-524 NN denotes cells
T348 517-518 -RRB- denotes )
T347 502-517 JJ denotes erythroleukemic
T346 501-502 -LRB- denotes (
T345 495-500 NN denotes GM979
T344 492-494 IN denotes in
T343 485-491 NN denotes assays
T342 472-484 NN denotes Transfection
T341 459-470 NN denotes circulation
T340 453-458 JJ denotes fetal
T339 449-452 DT denotes the
T338 446-448 IN denotes in
T337 438-445 JJ denotes present
T336 434-437 VB denotes are
T335 428-433 NN denotes cells
T334 424-427 JJ denotes red
T333 414-423 JJ denotes nucleated
T332 411-413 IN denotes of
T331 403-410 NN denotes numbers
T330 393-402 VB denotes increased
T329 389-392 CC denotes and
T328 387-388 -COMMA- denotes ,
T327 378-387 VB denotes expressed
T326 365-377 RB denotes persistently
T325 362-364 VB denotes is
T324 355-361 NN denotes globin
T323 352-354 JJ denotes ɛy
T322 350-351 -COMMA- denotes ,
T321 345-350 NN denotes p100H
T320 343-344 -COMMA- denotes ,
T319 338-343 NN denotes mouse
T318 323-337 JJ denotes Sox6-deficient
T317 319-322 DT denotes the
T316 316-318 IN denotes In
T315 308-314 NN denotes muscle
T314 304-307 CC denotes and
T313 302-303 -COMMA- denotes ,
T312 293-302 NN denotes cartilage
T311 291-292 -COMMA- denotes ,
T310 285-291 NN denotes system
T309 277-284 JJ denotes nervous
T308 269-276 JJ denotes central
T307 265-268 DT denotes the
T306 262-264 IN denotes of
T305 250-261 NN denotes development
T304 246-249 DT denotes the
T303 243-245 IN denotes in
T302 238-242 NN denotes role
T301 236-237 DT denotes a
T300 230-235 VB denotes plays
T299 225-229 NN denotes Sox6
T298 220-224 IN denotes that
T297 210-219 VB denotes suggested
T296 205-209 VB denotes have
T295 197-204 NN denotes studies
T294 188-196 NNP denotes Previous
T293 183-187 NNP denotes Sry.
T292 181-182 -COMMA- denotes ,
T291 177-181 NN denotes gene
T290 165-176 VB denotes determining
T289 158-164 NN denotes testis
T288 154-157 DT denotes the
T287 151-153 IN denotes in
T286 141-150 VB denotes described
T285 135-140 RB denotes first
T284 133-134 -COMMA- denotes ,
T283 127-133 NN denotes domain
T282 119-126 NN denotes binding
T281 115-118 NN denotes DNA
T280 113-114 -RRB- denotes )
T279 110-113 NN denotes HMG
T278 109-110 -LRB- denotes (
T277 103-108 NN denotes group
T276 94-102 NN denotes mobility
T275 89-93 JJ denotes high
T274 79-88 VB denotes conserved
T273 75-78 DT denotes the
T272 72-74 IN denotes by
T271 64-71 VB denotes defined
T270 61-63 VB denotes is
T269 56-60 WDT denotes that
T268 49-55 NN denotes family
T267 42-48 NN denotes factor
T266 28-41 NN denotes transcription
T265 24-27 NN denotes Sox
T264 20-23 DT denotes the
T263 17-19 IN denotes of
T262 10-16 NN denotes member
T261 8-9 DT denotes a
T260 5-7 VB denotes is
T259 0-4 NN denotes Sox6
T431 1035-1044 NN denotes silencing
T430 1031-1034 IN denotes for
T432 1045-1047 IN denotes of
R50 T259 T260 arg1Of Sox6,is
R51 T262 T260 arg2Of member,is
R52 T262 T261 arg1Of member,a
R53 T262 T263 arg1Of member,of
R54 T262 T269 arg1Of member,that
R55 T262 T270 arg1Of member,is
R56 T262 T271 arg2Of member,defined
R57 T268 T263 arg2Of family,of
R58 T268 T264 arg1Of family,the
R59 T268 T265 arg1Of family,Sox
R60 T268 T266 arg1Of family,transcription
R61 T268 T267 arg1Of family,factor
R62 T271 T270 arg2Of defined,is
R63 T279 T278 arg2Of HMG,(
R64 T280 T278 arg3Of ),(
R65 T283 T271 arg1Of domain,defined
R66 T283 T272 arg2Of domain,by
R67 T283 T273 arg1Of domain,the
R68 T283 T274 arg2Of domain,conserved
R69 T283 T275 arg1Of domain,high
R70 T283 T276 arg1Of domain,mobility
R71 T283 T277 arg1Of domain,group
R72 T283 T278 arg1Of domain,(
R73 T283 T281 arg1Of domain,DNA
R74 T283 T282 arg1Of domain,binding
R75 T283 T284 arg1Of domain,","
R76 T283 T286 arg2Of domain,described
R77 T286 T285 arg1Of described,first
R78 T286 T287 arg1Of described,in
R79 T289 T287 arg2Of testis,in
R80 T289 T288 arg1Of testis,the
R81 T289 T290 arg1Of testis,determining
R82 T291 T290 arg2Of gene,determining
R83 T291 T296 modOf gene,have
R84 T294 T293 arg1Of Previous,Sry.
R85 T295 T294 arg1Of studies,Previous
R86 T295 T296 arg1Of studies,have
R87 T295 T297 arg1Of studies,suggested
R88 T297 T292 arg1Of suggested,","
R89 T297 T296 arg2Of suggested,have
R90 T299 T300 arg1Of Sox6,plays
R91 T300 T297 arg2Of plays,suggested
R92 T300 T298 arg1Of plays,that
R93 T300 T303 arg1Of plays,in
R94 T302 T300 arg2Of role,plays
R95 T302 T301 arg1Of role,a
R96 T305 T306 arg1Of development,of
R97 T305 T311 arg1Of development,","
R98 T310 T306 arg2Of system,of
R99 T310 T307 arg1Of system,the
R100 T310 T308 arg1Of system,central
R101 T310 T309 arg1Of system,nervous
R102 T311 T314 arg1Of ",",and
R103 T312 T311 arg2Of cartilage,","
R104 T314 T303 arg2Of and,in
R105 T314 T304 arg1Of and,the
R106 T314 T313 arg1Of and,","
R107 T315 T314 arg2Of muscle,and
R108 T319 T316 arg2Of mouse,In
R109 T319 T317 arg1Of mouse,the
R110 T319 T318 arg1Of mouse,Sox6-deficient
R111 T319 T320 arg1Of mouse,","
R112 T321 T320 arg2Of p100H,","
R113 T324 T323 arg1Of globin,ɛy
R114 T324 T325 arg1Of globin,is
R115 T324 T327 arg2Of globin,expressed
R116 T327 T325 arg2Of expressed,is
R117 T327 T326 arg1Of expressed,persistently
R118 T327 T329 arg1Of expressed,and
R119 T329 T316 arg1Of and,In
R120 T329 T322 arg1Of and,","
R121 T329 T328 arg1Of and,","
R122 T331 T330 arg2Of numbers,increased
R123 T331 T332 arg1Of numbers,of
R124 T331 T336 arg1Of numbers,are
R125 T331 T337 arg1Of numbers,present
R126 T335 T332 arg2Of cells,of
R127 T335 T333 arg1Of cells,nucleated
R128 T335 T334 arg1Of cells,red
R129 T336 T329 arg2Of are,and
R130 T337 T336 arg2Of present,are
R131 T337 T338 arg1Of present,in
R132 T341 T338 arg2Of circulation,in
R133 T341 T339 arg1Of circulation,the
R134 T341 T340 arg1Of circulation,fetal
R135 T343 T342 arg1Of assays,Transfection
R136 T343 T344 arg1Of assays,in
R137 T343 T350 arg1Of assays,define
R138 T347 T346 arg2Of erythroleukemic,(
R139 T348 T346 arg3Of ),(
R140 T349 T344 arg2Of cells,in
R141 T349 T345 arg1Of cells,GM979
R142 T349 T346 arg1Of cells,(
R143 T354 T350 arg2Of region,define
R144 T354 T351 arg1Of region,a
R145 T354 T352 arg1Of region,36–base
R146 T354 T353 arg1Of region,pair
R147 T354 T355 arg1Of region,of
R148 T359 T355 arg2Of promoter,of
R149 T359 T356 arg1Of promoter,the
R150 T359 T357 arg1Of promoter,ɛy
R151 T359 T358 arg1Of promoter,proximal
R152 T359 T360 arg1Of promoter,that
R153 T359 T361 arg1Of promoter,is
R154 T359 T362 arg1Of promoter,critical
R155 T362 T361 arg2Of critical,is
R156 T362 T363 arg1Of critical,for
R157 T366 T363 arg2Of repression,for
R158 T366 T364 arg1Of repression,Sox6
R159 T366 T365 arg2Of repression,mediated
R160 T370 T367 arg1Of assay,Electrophoretic
R161 T370 T368 arg1Of assay,mobility
R162 T370 T369 arg1Of assay,shift
R163 T370 T371 arg1Of assay,(
R164 T370 T374 arg1Of assay,and
R165 T372 T371 arg2Of EMSA,(
R166 T373 T371 arg3Of ),(
R167 T374 T381 arg1Of and,demonstrate
R168 T378 T377 arg2Of ChIP,(
R169 T379 T377 arg3Of ),(
R170 T380 T374 arg2Of assays,and
R171 T380 T375 arg1Of assays,chromatin
R172 T380 T376 arg1Of assays,immunoprecipitation
R173 T380 T377 arg1Of assays,(
R174 T383 T384 arg1Of Sox6,acts
R175 T384 T381 arg2Of acts,demonstrate
R176 T384 T382 arg1Of acts,that
R177 T384 T385 arg1Of acts,as
R178 T384 T388 arg1Of acts,by
R179 T387 T385 arg2Of repressor,as
R180 T387 T386 arg1Of repressor,a
R181 T390 T388 arg2Of binding,by
R182 T390 T389 arg1Of binding,directly
R183 T390 T391 arg1Of binding,to
R184 T394 T391 arg2Of promoter,to
R185 T394 T392 arg1Of promoter,the
R186 T394 T393 arg1Of promoter,ɛy
R187 T397 T395 arg1Of expression,The
R188 T397 T396 arg1Of expression,normal
R189 T397 T398 arg1Of expression,of
R190 T397 T400 arg1Of expression,in
R191 T397 T404 arg1Of expression,and
R192 T399 T398 arg2Of Sox6,of
R193 T403 T400 arg2Of liver,in
R194 T403 T401 arg1Of liver,wild-type
R195 T403 T402 arg1Of liver,fetal
R196 T404 T415 arg1Of and,demonstrate
R197 T407 T404 arg2Of expression,and
R198 T407 T405 arg1Of expression,the
R199 T407 T406 arg1Of expression,ectopic
R200 T407 T408 arg1Of expression,of
R201 T407 T410 arg1Of expression,in
R202 T409 T408 arg2Of ɛy,of
R203 T414 T410 arg2Of liver,in
R204 T414 T411 arg1Of liver,p100H
R205 T414 T412 arg1Of liver,homozygous
R206 T414 T413 arg1Of liver,fetal
R207 T415 T419 arg1Of demonstrate,in
R208 T418 T415 arg2Of functions,demonstrate
R209 T418 T416 arg1Of functions,that
R210 T418 T417 arg1Of functions,Sox6
R211 T421 T419 arg2Of erythropoiesis,in
R212 T421 T420 arg1Of erythropoiesis,definitive
R213 T424 T422 arg1Of study,The
R214 T424 T423 arg1Of study,present
R215 T424 T425 arg1Of study,shows
R216 T427 T428 arg1Of Sox6,is
R217 T427 T429 arg2Of Sox6,required
R218 T427 T439 arg1Of Sox6,suggests
R219 T429 T428 arg2Of required,is
R220 T429 T430 arg1Of required,for
R221 T429 T438 arg1Of required,and
R222 T431 T430 arg2Of silencing,for
R223 T431 T432 arg1Of silencing,of
R224 T431 T435 arg1Of silencing,in
R225 T434 T432 arg2Of globin,of
R226 T434 T433 arg1Of globin,ɛy
R227 T437 T435 arg2Of erythropoiesis,in
R228 T437 T436 arg1Of erythropoiesis,definitive
R229 T438 T425 arg2Of and,shows
R230 T438 T426 arg1Of and,that
R231 T439 T438 arg2Of suggests,and
R232 T441 T439 arg2Of role,suggests
R233 T441 T440 arg1Of role,a
R234 T441 T442 arg1Of role,for
R235 T441 T444 arg1Of role,in
R236 T443 T442 arg2Of Sox6,for
R237 T447 T444 arg2Of maturation,in
R238 T447 T445 arg1Of maturation,erythroid
R239 T447 T446 arg1Of maturation,cell
R240 T451 T450 arg1Of regulation,Sox6
R241 T451 T452 arg1Of regulation,of
R242 T451 T455 arg1Of regulation,might
R243 T451 T456 arg1Of regulation,provide
R244 T454 T452 arg2Of globin,of
R245 T454 T453 arg1Of globin,ɛy
R246 T456 T448 arg1Of provide,Thus
R247 T456 T449 arg1Of provide,","
R248 T456 T455 arg2Of provide,might
R249 T460 T456 arg2Of target,provide
R250 T460 T457 arg1Of target,a
R251 T460 T458 arg1Of target,novel
R252 T460 T459 arg1Of target,therapeutical
R253 T460 T461 arg1Of target,in
R254 T463 T461 arg2Of treatment,in
R255 T463 T462 arg1Of treatment,the
R256 T463 T464 arg1Of treatment,of
R257 T465 T464 arg2Of hemoglobinopathies,of
R258 T465 T467 arg1Of hemoglobinopathies,as
R259 T467 T466 arg1Of as,such
R260 T470 T471 arg1Of anemia,and
R261 T471 T467 arg2Of and,as
R262 T471 T468 arg1Of and,sickle
R263 T471 T469 arg1Of and,cell
R264 T472 T471 arg2Of thalassemia,and

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T148 0-4 Protein denotes Sox6
T149 183-186 Protein denotes Sry
T150 225-229 Protein denotes Sox6
T151 323-327 Protein denotes Sox6
T152 352-361 Protein denotes ɛy globin
T153 561-563 Protein denotes ɛy
T154 603-607 Protein denotes Sox6
T155 738-742 Protein denotes Sox6
T156 790-792 Protein denotes ɛy
T157 828-832 Protein denotes Sox6
T158 888-890 Protein denotes ɛy
T159 940-944 Protein denotes Sox6
T160 1014-1018 Protein denotes Sox6
T161 1048-1057 Protein denotes ɛy globin
T162 1111-1115 Protein denotes Sox6
T163 1152-1156 Protein denotes Sox6
T164 1171-1180 Protein denotes ɛy globin

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T474 0-4 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T475 225-229 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T476 323-327 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T477 603-607 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T478 738-742 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T479 828-832 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T480 940-944 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T481 1014-1018 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T482 1111-1115 http://www.uniprot.org/uniprot/P35712 denotes Sox6
T483 1152-1156 http://www.uniprot.org/uniprot/P35712 denotes Sox6

UBERON-AE

Id Subject Object Predicate Lexical cue
T86 158-164 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testis
T87 269-276 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T88 269-291 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T89 277-291 http://purl.obolibrary.org/obo/UBERON_0001016 denotes nervous system
T90 852-857 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T91 917-922 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver

GO-BP

Id Subject Object Predicate Lexical cue
T112 250-291 http://purl.obolibrary.org/obo/GO_0007417 denotes development of the central nervous system
T111 250-261 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T110 28-41 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T109 1072-1086 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T108 969-983 http://purl.obolibrary.org/obo/GO_0030218 denotes erythropoiesis
T106 1061-1086 http://purl.obolibrary.org/obo/GO_0060318 denotes definitive erythropoiesis
T105 958-983 http://purl.obolibrary.org/obo/GO_0060318 denotes definitive erythropoiesis
T103 1174-1180 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T102 1051-1057 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T101 355-361 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T113 250-291 http://purl.obolibrary.org/obo/GO_0021954 denotes development of the central nervous system
T114 1129-1144 http://purl.obolibrary.org/obo/GO_0048469 denotes cell maturation
T115 1157-1167 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

GO-MF

Id Subject Object Predicate Lexical cue
T166 355-361 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T167 1051-1057 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T168 1174-1180 http://purl.obolibrary.org/obo/GO_0005344 denotes globin
T169 115-126 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T170 115-133 http://purl.obolibrary.org/obo/GO_0050692 denotes DNA binding domain
T171 119-126 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T172 775-782 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T174 428-433 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T175 519-524 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T176 1129-1133 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T177 1278-1282 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T178 677-686 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin

sentences

Id Subject Object Predicate Lexical cue
T99 1146-1306 Sentence denotes Thus, Sox6 regulation of ɛy globin might provide a novel therapeutical target in the treatment of hemoglobinopathies such as sickle cell anemia and thalassemia.
T98 985-1145 Sentence denotes The present study shows that Sox6 is required for silencing of ɛy globin in definitive erythropoiesis and suggests a role for Sox6 in erythroid cell maturation.
T97 803-984 Sentence denotes The normal expression of Sox6 in wild-type fetal liver and the ectopic expression of ɛy in p100H homozygous fetal liver demonstrate that Sox6 functions in definitive erythropoiesis.
T96 629-802 Sentence denotes Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assays demonstrate that Sox6 acts as a repressor by directly binding to the ɛy promoter.
T95 472-628 Sentence denotes Transfection assays in GM979 (erythroleukemic) cells define a 36–base pair region of the ɛy proximal promoter that is critical for Sox6 mediated repression.
T94 316-471 Sentence denotes In the Sox6-deficient mouse, p100H, ɛy globin is persistently expressed, and increased numbers of nucleated red cells are present in the fetal circulation.
T93 0-315 Sentence denotes Sox6 is a member of the Sox transcription factor family that is defined by the conserved high mobility group (HMG) DNA binding domain, first described in the testis determining gene, Sry. Previous studies have suggested that Sox6 plays a role in the development of the central nervous system, cartilage, and muscle.
T4 0-187 Sentence denotes Sox6 is a member of the Sox transcription factor family that is defined by the conserved high mobility group (HMG) DNA binding domain, first described in the testis determining gene, Sry.
T5 188-315 Sentence denotes Previous studies have suggested that Sox6 plays a role in the development of the central nervous system, cartilage, and muscle.
T6 316-471 Sentence denotes In the Sox6-deficient mouse, p100H, ɛy globin is persistently expressed, and increased numbers of nucleated red cells are present in the fetal circulation.
T7 472-628 Sentence denotes Transfection assays in GM979 (erythroleukemic) cells define a 36–base pair region of the ɛy proximal promoter that is critical for Sox6 mediated repression.
T8 629-802 Sentence denotes Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assays demonstrate that Sox6 acts as a repressor by directly binding to the ɛy promoter.
T9 803-984 Sentence denotes The normal expression of Sox6 in wild-type fetal liver and the ectopic expression of ɛy in p100H homozygous fetal liver demonstrate that Sox6 functions in definitive erythropoiesis.
T10 985-1145 Sentence denotes The present study shows that Sox6 is required for silencing of ɛy globin in definitive erythropoiesis and suggests a role for Sox6 in erythroid cell maturation.
T11 1146-1306 Sentence denotes Thus, Sox6 regulation of ɛy globin might provide a novel therapeutical target in the treatment of hemoglobinopathies such as sickle cell anemia and thalassemia.

ICD10

Id Subject Object Predicate Lexical cue
T173 277-284 http://purl.bioontology.org/ontology/ICD10/R45.0 denotes nervous

simple1

Id Subject Object Predicate Lexical cue
T249 1171-1180 Protein denotes ɛy globin
T248 1152-1156 Protein denotes Sox6
T247 1111-1115 Protein denotes Sox6
T246 1048-1057 Protein denotes ɛy globin
T245 1014-1018 Protein denotes Sox6
T244 940-944 Protein denotes Sox6
T243 888-890 Protein denotes ɛy
T242 828-832 Protein denotes Sox6
T241 790-792 Protein denotes ɛy
T240 738-742 Protein denotes Sox6
T239 603-607 Protein denotes Sox6
T238 561-563 Protein denotes ɛy
T237 352-361 Protein denotes ɛy globin
T236 323-327 Protein denotes Sox6
T235 225-229 Protein denotes Sox6
T234 183-186 Protein denotes Sry
T233 0-4 Protein denotes Sox6

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T878 0-4 Protein denotes Sox6
T879 183-186 Protein denotes Sry
T880 225-229 Protein denotes Sox6
T881 323-327 Protein denotes Sox6
T882 352-361 Protein denotes ɛy globin
T883 561-563 Protein denotes ɛy
T884 603-607 Protein denotes Sox6
T885 738-742 Protein denotes Sox6
T886 790-792 Protein denotes ɛy
T887 828-832 Protein denotes Sox6
T888 888-890 Protein denotes ɛy
T889 940-944 Protein denotes Sox6
T890 1014-1018 Protein denotes Sox6
T891 1048-1057 Protein denotes ɛy globin
T892 1111-1115 Protein denotes Sox6
T893 1152-1156 Protein denotes Sox6
T894 1171-1180 Protein denotes ɛy globin
T896 378-387 Gene_expression denotes expressed
T897 328-337 Negative_regulation denotes deficient
T898 617-627 Negative_regulation denotes repression
T899 775-782 Binding denotes binding
T900 874-884 Gene_expression denotes expression
T901 814-824 Gene_expression denotes expression
T902 1022-1030 Positive_regulation denotes required
T903 1035-1044 Negative_regulation denotes silencing
T904 1157-1167 Regulation denotes regulation
R589 T885 T899 themeOf Sox6,binding
R591 T887 T901 themeOf Sox6,expression
R592 T888 T900 themeOf ɛy,expression
R593 T891 T903 themeOf ɛy globin,silencing
R594 T893 T904 themeOf Sox6,regulation
R595 T894 T904 themeOf ɛy globin,regulation
R596 T903 T902 themeOf silencing,required
R586 T881 T897 themeOf Sox6,deficient
R587 T882 T896 themeOf ɛy globin,expressed
R588 T884 T898 themeOf Sox6,repression
R590 T886 T899 themeOf ɛy,binding

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T486 0-4 Protein denotes Sox6
T487 183-186 Protein denotes Sry
T488 225-229 Protein denotes Sox6
T489 323-327 Protein denotes Sox6
T490 352-361 Protein denotes ɛy globin
T491 561-563 Protein denotes ɛy
T492 603-607 Protein denotes Sox6
T493 738-742 Protein denotes Sox6
T494 790-792 Protein denotes ɛy
T495 828-832 Protein denotes Sox6
T496 888-890 Protein denotes ɛy
T497 940-944 Protein denotes Sox6
T498 1014-1018 Protein denotes Sox6
T499 1048-1057 Protein denotes ɛy globin
T500 1111-1115 Protein denotes Sox6
T501 1152-1156 Protein denotes Sox6
T502 1171-1180 Protein denotes ɛy globin
T505 328-337 Negative_regulation denotes deficient
T506 378-387 Gene_expression denotes expressed
T507 608-616 Positive_regulation denotes mediated
T508 617-627 Negative_regulation denotes repression
T509 775-782 Binding denotes binding
T510 874-884 Gene_expression denotes expression
T511 814-824 Gene_expression denotes expression
T512 1035-1044 Negative_regulation denotes silencing
T513 1022-1030 Positive_regulation denotes required
T514 1157-1167 Regulation denotes regulation
R447 T489 T505 themeOf Sox6,deficient
R448 T490 T506 themeOf ɛy globin,expressed
R449 T492 T508 themeOf Sox6,repression
R450 T493 T509 themeOf Sox6,binding
R451 T494 T509 themeOf ɛy,binding
R452 T495 T511 themeOf Sox6,expression
R453 T496 T510 themeOf ɛy,expression
R454 T498 T513 causeOf Sox6,required
R455 T499 T512 themeOf ɛy globin,silencing
R456 T501 T514 themeOf Sox6,regulation
R457 T502 T514 themeOf ɛy globin,regulation
R459 T508 T507 themeOf repression,mediated
R460 T512 T513 themeOf silencing,required

DLUT931

Id Subject Object Predicate Lexical cue
T545 1217-1223 Regulation denotes target
T544 1157-1167 Regulation denotes regulation
T543 1022-1030 Positive_regulation denotes required
T542 1035-1044 Negative_regulation denotes silencing
T541 866-873 Negative_regulation denotes ectopic
T540 874-884 Gene_expression denotes expression
T539 814-824 Gene_expression denotes expression
T517 0-4 Protein denotes Sox6
T518 183-186 Protein denotes Sry
T519 225-229 Protein denotes Sox6
T520 323-327 Protein denotes Sox6
T521 352-361 Protein denotes ɛy globin
T522 561-563 Protein denotes ɛy
T523 603-607 Protein denotes Sox6
T524 738-742 Protein denotes Sox6
T525 790-792 Protein denotes ɛy
T526 828-832 Protein denotes Sox6
T527 888-890 Protein denotes ɛy
T528 940-944 Protein denotes Sox6
T529 1014-1018 Protein denotes Sox6
T530 1048-1057 Protein denotes ɛy globin
T531 1111-1115 Protein denotes Sox6
T532 1152-1156 Protein denotes Sox6
T533 1171-1180 Protein denotes ɛy globin
T536 328-337 Negative_regulation denotes deficient
T537 378-387 Gene_expression denotes expressed
T538 775-782 Binding denotes binding
R265 T540 T541 themeOf expression,ectopic
R266 T542 T543 themeOf silencing,required
R267 T544 T545 themeOf regulation,target
R268 T544 T545 themeOf regulation,target
R463 T520 T536 themeOf Sox6,deficient
R464 T521 T537 themeOf ɛy globin,expressed
R465 T524 T538 themeOf Sox6,binding
R466 T525 T538 themeOf ɛy,binding
R467 T526 T539 themeOf Sox6,expression
R468 T527 T540 themeOf ɛy,expression
R469 T529 T543 causeOf Sox6,required
R470 T530 T542 themeOf ɛy globin,silencing
R471 T532 T544 themeOf Sox6,regulation
R472 T533 T544 themeOf ɛy globin,regulation

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T875 154-186 Localization denotes the testis determining gene, Sry
T874 1035-1086 Negative_regulation denotes silencing of ɛy globin in definitive erythropoiesis
T873 599-627 Regulation denotes for Sox6 mediated repression
T872 803-899 Gene_expression denotes The normal expression of Sox6 in wild-type fetal liver and the ectopic expression of ɛy in p100H
T871 352-387 Gene_expression denotes ɛy globin is persistently expressed
T870 1152-1180 Regulation denotes Sox6 regulation of ɛy globin
T869 862-899 Gene_expression denotes the ectopic expression of ɛy in p100H
T867 766-801 Binding denotes directly binding to the ɛy promoter
T866 561-563 Protein denotes ɛy
T845 940-944 Protein denotes Sox6
T838 24-27 Protein denotes Sox
T839 519-524 Entity denotes cells
T840 783-801 Entity denotes to the ɛy promoter
T841 1244-1289 Entity denotes hemoglobinopathies such as sickle cell anemia
T842 1014-1018 Protein denotes Sox6
T844 0-4 Protein denotes Sox6
T846 154-186 Protein denotes the testis determining gene, Sry
T847 1152-1156 Protein denotes Sox6
T849 885-890 Protein denotes of ɛy
T850 345-350 Entity denotes p100H
T851 20-55 Protein denotes the Sox transcription factor family
T852 825-832 Protein denotes of Sox6
T853 352-361 Protein denotes ɛy globin
T854 894-899 Entity denotes p100H
T855 677-686 Entity denotes chromatin
T856 225-229 Protein denotes Sox6
T857 1045-1057 Protein denotes of ɛy globin
T858 790-792 Protein denotes ɛy
T859 554-581 Entity denotes of the ɛy proximal promoter
T860 1168-1180 Protein denotes of ɛy globin
T861 599-627 Protein denotes for Sox6 mediated repression
T862 738-742 Protein denotes Sox6
T863 1111-1115 Protein denotes Sox6
T864 154-186 Protein denotes the testis determining gene, Sry
T865 115-186 Entity denotes DNA binding domain, first described in the testis determining gene, Sry
R573 T840 T858 partOf to the ɛy promoter,ɛy
R574 T840 T867 themeOf to the ɛy promoter,directly binding to the ɛy promoter
R576 T846 T875 themeOf "the testis determining gene, Sry","the testis determining gene, Sry"
R577 T847 T870 causeOf Sox6,Sox6 regulation of ɛy globin
R578 T849 T869 themeOf of ɛy,the ectopic expression of ɛy in p100H
R579 T852 T872 themeOf of Sox6,The normal expression of Sox6 in wild-type fetal liver and the ectopic expression of ɛy in p100H
R580 T853 T871 themeOf ɛy globin,ɛy globin is persistently expressed
R581 T857 T874 themeOf of ɛy globin,silencing of ɛy globin in definitive erythropoiesis
R582 T859 T866 partOf of the ɛy proximal promoter,ɛy
R583 T860 T870 themeOf of ɛy globin,Sox6 regulation of ɛy globin
R584 T861 T873 themeOf for Sox6 mediated repression,for Sox6 mediated repression

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T719 783-785 TO denotes to
T718 775-782 JJ denotes binding
T717 766-774 RB denotes directly
T716 763-765 IN denotes by
T715 753-762 NN denotes repressor
T714 751-752 DT denotes a
T713 748-750 IN denotes as
T712 743-747 NNS denotes acts
T711 738-742 JJ denotes Sox6
T710 733-737 IN denotes that
T709 721-732 VBP denotes demonstrate
T708 714-720 NNS denotes assays
T707 712-713 -RRB- denotes )
T706 708-712 NNP denotes ChIP
T705 707-708 -LRB- denotes (
T704 687-706 NN denotes immunoprecipitation
T703 677-686 NN denotes chromatin
T702 673-676 CC denotes and
T701 671-672 -RRB- denotes )
T700 667-671 NNP denotes EMSA
T699 666-667 -LRB- denotes (
T698 660-665 NN denotes assay
T697 654-659 NN denotes shift
T696 645-653 NN denotes mobility
T695 629-644 JJ denotes Electrophoretic
T694 627-628 . denotes .
T693 617-627 NN denotes repression
T692 608-616 VBN denotes mediated
T691 603-607 JJ denotes Sox6
T690 599-602 IN denotes for
T689 590-598 JJ denotes critical
T688 587-589 VBZ denotes is
T687 582-586 WDT denotes that
T686 573-581 NN denotes promoter
T685 564-572 JJ denotes proximal
T684 561-563 JJ denotes ɛy
T683 557-560 DT denotes the
T682 554-556 IN denotes of
T681 547-553 NN denotes region
T680 542-546 NN denotes pair
T679 537-541 JJ denotes base
T678 534-536 CD denotes 36
T677 532-533 DT denotes a
T676 525-531 VBP denotes define
T675 519-524 NNS denotes cells
T674 517-518 -RRB- denotes )
T673 502-517 JJ denotes erythroleukemic
T672 501-502 -LRB- denotes (
T671 495-500 NNP denotes GM979
T670 492-494 IN denotes in
T669 485-491 NNS denotes assays
T668 472-484 NNP denotes Transfection
T667 470-471 . denotes .
T666 459-470 NN denotes circulation
T665 453-458 JJ denotes fetal
T664 449-452 DT denotes the
T663 446-448 IN denotes in
T662 438-445 JJ denotes present
T661 434-437 VBP denotes are
T660 428-433 NNS denotes cells
T659 424-427 JJ denotes red
T658 414-423 JJ denotes nucleated
T657 411-413 IN denotes of
T656 403-410 NNS denotes numbers
T655 393-402 VBD denotes increased
T654 389-392 CC denotes and
T653 387-388 , denotes ,
T652 378-387 VBN denotes expressed
T651 365-377 RB denotes persistently
T650 362-364 VBZ denotes is
T649 355-361 NN denotes globin
T648 352-354 JJ denotes ɛy
T647 350-351 , denotes ,
T646 345-350 NNP denotes p100H
T645 343-344 , denotes ,
T644 338-343 NN denotes mouse
T643 323-337 JJ denotes Sox6-deficient
T642 319-322 DT denotes the
T641 316-318 IN denotes In
T640 314-315 . denotes .
T639 308-314 NN denotes muscle
T638 304-307 CC denotes and
T637 302-303 , denotes ,
T636 293-302 NN denotes cartilage
T635 291-292 , denotes ,
T634 285-291 NN denotes system
T633 277-284 JJ denotes nervous
T632 269-276 JJ denotes central
T631 265-268 DT denotes the
T630 262-264 IN denotes of
T629 250-261 NN denotes development
T628 246-249 DT denotes the
T627 243-245 IN denotes in
T626 238-242 NN denotes role
T625 236-237 DT denotes a
T624 230-235 NNS denotes plays
T623 225-229 JJ denotes Sox6
T622 220-224 IN denotes that
T621 210-219 VBN denotes suggested
T620 205-209 VBP denotes have
T619 197-204 NNS denotes studies
T618 188-196 JJ denotes Previous
T617 186-187 . denotes .
T616 183-186 NNP denotes Sry
T615 181-182 , denotes ,
T614 177-181 NN denotes gene
T613 165-176 VBG denotes determining
T612 158-164 NN denotes testis
T611 154-157 DT denotes the
T610 151-153 IN denotes in
T609 141-150 VBN denotes described
T608 135-140 JJ denotes first
T607 133-134 , denotes ,
T606 127-133 NN denotes domain
T605 119-126 JJ denotes binding
T604 115-118 NNP denotes DNA
T603 113-114 -RRB- denotes )
T602 110-113 NNP denotes HMG
T601 109-110 -LRB- denotes (
T600 103-108 NN denotes group
T599 94-102 NN denotes mobility
T598 89-93 JJ denotes high
T597 79-88 JJ denotes conserved
T596 75-78 DT denotes the
T595 72-74 IN denotes by
T594 64-71 VBN denotes defined
T593 61-63 VBZ denotes is
T592 56-60 WDT denotes that
T591 49-55 NN denotes family
T590 42-48 NN denotes factor
T589 28-41 NN denotes transcription
T588 24-27 NNPS denotes Sox
T587 20-23 DT denotes the
T586 17-19 IN denotes of
T585 10-16 NN denotes member
T584 8-9 DT denotes a
T583 5-7 VBZ denotes is
T582 0-4 NNP denotes Sox6
T798 1268-1270 IN denotes as
T799 1271-1277 JJ denotes sickle
T720 786-789 DT denotes the
T721 790-792 JJ denotes ɛy
T722 793-801 NN denotes promoter
T723 801-802 . denotes .
T724 803-806 DT denotes The
T725 807-813 JJ denotes normal
T726 814-824 NN denotes expression
T727 825-827 IN denotes of
T728 828-832 NNP denotes Sox6
T729 833-835 IN denotes in
T730 836-845 JJ denotes wild-type
T731 846-851 JJ denotes fetal
T732 852-857 NN denotes liver
T733 858-861 CC denotes and
T734 862-865 DT denotes the
T735 866-873 JJ denotes ectopic
T736 874-884 NN denotes expression
T737 885-887 IN denotes of
T738 888-890 NN denotes ɛy
T739 891-893 IN denotes in
T740 894-899 JJ denotes p100H
T741 900-910 JJ denotes homozygous
T742 911-916 JJ denotes fetal
T743 917-922 NN denotes liver
T744 923-934 VBP denotes demonstrate
T745 935-939 IN denotes that
T746 940-944 JJ denotes Sox6
T747 945-954 NNS denotes functions
T748 955-957 IN denotes in
T749 958-968 JJ denotes definitive
T750 969-983 NNS denotes erythropoiesis
T751 983-984 . denotes .
T752 985-988 DT denotes The
T753 989-996 JJ denotes present
T754 997-1002 NN denotes study
T755 1003-1008 VBZ denotes shows
T756 1009-1013 IN denotes that
T757 1014-1018 NNP denotes Sox6
T758 1019-1021 VBZ denotes is
T759 1022-1030 VBN denotes required
T760 1031-1034 IN denotes for
T761 1035-1044 VBG denotes silencing
T762 1045-1047 IN denotes of
T763 1048-1050 JJ denotes ɛy
T764 1051-1057 NN denotes globin
T765 1058-1060 IN denotes in
T766 1061-1071 JJ denotes definitive
T767 1072-1086 NNS denotes erythropoiesis
T768 1087-1090 CC denotes and
T800 1278-1282 NN denotes cell
T769 1091-1099 VBZ denotes suggests
T770 1100-1101 DT denotes a
T771 1102-1106 NN denotes role
T772 1107-1110 IN denotes for
T773 1111-1115 NNP denotes Sox6
T774 1116-1118 IN denotes in
T775 1119-1128 JJ denotes erythroid
T776 1129-1133 NN denotes cell
T777 1134-1144 NN denotes maturation
T778 1144-1145 . denotes .
T779 1146-1150 RB denotes Thus
T780 1150-1151 , denotes ,
T781 1152-1156 JJ denotes Sox6
T782 1157-1167 NN denotes regulation
T783 1168-1170 IN denotes of
T784 1171-1173 JJ denotes ɛy
T785 1174-1180 NN denotes globin
T786 1181-1186 MD denotes might
T787 1187-1194 VB denotes provide
T788 1195-1196 DT denotes a
T789 1197-1202 NN denotes novel
T790 1203-1216 JJ denotes therapeutical
T791 1217-1223 NN denotes target
T792 1224-1226 IN denotes in
T793 1227-1230 DT denotes the
T794 1231-1240 NN denotes treatment
T795 1241-1243 IN denotes of
T796 1244-1262 NNS denotes hemoglobinopathies
T797 1263-1267 JJ denotes such
T801 1283-1289 NN denotes anemia
T802 1290-1293 CC denotes and
T803 1294-1305 NN denotes thalassemia
T804 1305-1306 . denotes .
R279 T583 T583 ROOT is,is
R280 T584 T585 det a,member
R281 T585 T583 attr member,is
R282 T586 T585 prep of,member
R283 T587 T591 det the,family
R284 T588 T591 compound Sox,family
R285 T589 T590 compound transcription,factor
R286 T590 T591 compound factor,family
R287 T591 T586 pobj family,of
R288 T592 T594 nsubjpass that,defined
R289 T593 T594 auxpass is,defined
R290 T594 T585 relcl defined,member
R291 T595 T594 agent by,defined
R292 T596 T600 det the,group
R293 T597 T600 amod conserved,group
R294 T598 T600 amod high,group
R295 T599 T600 compound mobility,group
R296 T600 T595 pobj group,by
R297 T601 T602 punct (,HMG
R298 T602 T600 appos HMG,group
R299 T603 T602 punct ),HMG
R300 T604 T606 compound DNA,domain
R301 T605 T606 amod binding,domain
R302 T606 T600 conj domain,group
R303 T607 T606 punct ",",domain
R304 T608 T609 advmod first,described
R305 T609 T600 acl described,group
R306 T610 T609 prep in,described
R307 T611 T614 det the,gene
R308 T612 T614 amod testis,gene
R309 T613 T614 amod determining,gene
R310 T614 T610 pobj gene,in
R311 T615 T614 punct ",",gene
R312 T616 T614 appos Sry,gene
R313 T617 T583 punct .,is
R314 T618 T619 amod Previous,studies
R315 T619 T621 nsubj studies,suggested
R316 T620 T621 aux have,suggested
R317 T621 T621 ROOT suggested,suggested
R318 T622 T624 mark that,plays
R319 T623 T624 nsubj Sox6,plays
R320 T624 T621 ccomp plays,suggested
R321 T625 T626 det a,role
R322 T626 T624 dobj role,plays
R323 T627 T626 prep in,role
R324 T628 T629 det the,development
R325 T629 T627 pobj development,in
R326 T630 T629 prep of,development
R327 T631 T634 det the,system
R328 T632 T634 amod central,system
R329 T633 T634 amod nervous,system
R330 T634 T630 pobj system,of
R331 T635 T634 punct ",",system
R332 T636 T634 conj cartilage,system
R333 T637 T636 punct ",",cartilage
R334 T638 T636 cc and,cartilage
R335 T639 T636 conj muscle,cartilage
R336 T640 T621 punct .,suggested
R337 T641 T652 prep In,expressed
R338 T642 T644 det the,mouse
R339 T643 T644 amod Sox6-deficient,mouse
R340 T644 T641 pobj mouse,In
R341 T645 T652 punct ",",expressed
R342 T646 T652 nsubjpass p100H,expressed
R343 T647 T652 punct ",",expressed
R344 T648 T649 amod ɛy,globin
R345 T649 T652 nsubjpass globin,expressed
R346 T650 T652 auxpass is,expressed
R347 T651 T652 advmod persistently,expressed
R348 T652 T652 ROOT expressed,expressed
R349 T653 T652 punct ",",expressed
R350 T654 T652 cc and,expressed
R351 T655 T656 amod increased,numbers
R352 T656 T661 nsubj numbers,are
R353 T657 T656 prep of,numbers
R354 T658 T660 amod nucleated,cells
R355 T659 T660 amod red,cells
R356 T660 T657 pobj cells,of
R357 T661 T652 conj are,expressed
R358 T662 T661 acomp present,are
R359 T663 T662 prep in,present
R360 T664 T666 det the,circulation
R361 T665 T666 amod fetal,circulation
R362 T666 T663 pobj circulation,in
R363 T667 T661 punct .,are
R364 T668 T669 compound Transfection,assays
R365 T669 T676 nsubj assays,define
R366 T670 T669 prep in,assays
R367 T671 T670 pobj GM979,in
R368 T672 T673 punct (,erythroleukemic
R369 T673 T671 appos erythroleukemic,GM979
R370 T674 T673 punct ),erythroleukemic
R371 T675 T676 nsubj cells,define
R372 T676 T676 ROOT define,define
R373 T677 T681 det a,region
R374 T678 T681 nummod 36,region
R375 T679 T681 compound base,region
R376 T680 T681 compound pair,region
R377 T681 T676 dobj region,define
R378 T682 T681 prep of,region
R379 T683 T686 det the,promoter
R380 T684 T686 amod ɛy,promoter
R381 T685 T686 amod proximal,promoter
R382 T686 T682 pobj promoter,of
R383 T687 T688 nsubj that,is
R384 T688 T686 relcl is,promoter
R385 T689 T688 acomp critical,is
R386 T690 T689 prep for,critical
R387 T691 T693 amod Sox6,repression
R388 T692 T693 amod mediated,repression
R389 T693 T690 pobj repression,for
R390 T694 T676 punct .,define
R391 T695 T698 amod Electrophoretic,assay
R392 T696 T698 compound mobility,assay
R393 T697 T698 compound shift,assay
R394 T698 T708 nmod assay,assays
R395 T699 T700 punct (,EMSA
R396 T700 T698 appos EMSA,assay
R397 T701 T700 punct ),EMSA
R398 T702 T698 cc and,assay
R399 T703 T704 compound chromatin,immunoprecipitation
R400 T704 T698 conj immunoprecipitation,assay
R401 T705 T704 punct (,immunoprecipitation
R402 T706 T704 appos ChIP,immunoprecipitation
R403 T707 T704 punct ),immunoprecipitation
R404 T708 T709 nsubj assays,demonstrate
R405 T709 T709 ROOT demonstrate,demonstrate
R406 T710 T718 mark that,binding
R407 T711 T712 amod Sox6,acts
R408 T712 T718 nsubj acts,binding
R409 T713 T712 prep as,acts
R410 T714 T715 det a,repressor
R411 T715 T713 pobj repressor,as
R412 T716 T712 prep by,acts
R413 T717 T718 advmod directly,binding
R414 T718 T709 ccomp binding,demonstrate
R415 T719 T718 prep to,binding
R488 T720 T722 det the,promoter
R489 T721 T722 amod ɛy,promoter
R490 T722 T719 pobj promoter,to
R491 T723 T709 punct .,demonstrate
R492 T724 T726 det The,expression
R493 T725 T726 amod normal,expression
R494 T726 T744 nsubj expression,demonstrate
R495 T727 T726 prep of,expression
R496 T728 T727 pobj Sox6,of
R497 T729 T726 prep in,expression
R498 T730 T732 amod wild-type,liver
R499 T731 T732 amod fetal,liver
R500 T732 T729 pobj liver,in
R501 T733 T732 cc and,liver
R502 T734 T736 det the,expression
R503 T735 T736 amod ectopic,expression
R504 T736 T732 conj expression,liver
R505 T737 T736 prep of,expression
R506 T738 T737 pobj ɛy,of
R507 T739 T738 prep in,ɛy
R508 T740 T743 amod p100H,liver
R509 T741 T743 amod homozygous,liver
R510 T742 T743 amod fetal,liver
R511 T743 T739 pobj liver,in
R512 T744 T744 ROOT demonstrate,demonstrate
R513 T745 T744 dobj that,demonstrate
R514 T746 T747 amod Sox6,functions
R515 T747 T745 conj functions,that
R516 T748 T747 prep in,functions
R517 T749 T750 amod definitive,erythropoiesis
R518 T750 T748 pobj erythropoiesis,in
R519 T751 T744 punct .,demonstrate
R520 T752 T754 det The,study
R521 T753 T754 amod present,study
R522 T754 T755 nsubj study,shows
R523 T755 T755 ROOT shows,shows
R524 T756 T759 mark that,required
R525 T757 T759 nsubjpass Sox6,required
R526 T758 T759 auxpass is,required
R527 T759 T755 ccomp required,shows
R528 T760 T759 prep for,required
R529 T761 T760 pcomp silencing,for
R530 T762 T761 prep of,silencing
R531 T763 T764 amod ɛy,globin
R532 T764 T762 pobj globin,of
R533 T765 T761 prep in,silencing
R534 T766 T767 amod definitive,erythropoiesis
R535 T767 T765 pobj erythropoiesis,in
R536 T768 T759 cc and,required
R537 T769 T755 conj suggests,shows
R538 T770 T771 det a,role
R539 T771 T769 dobj role,suggests
R540 T772 T771 prep for,role
R541 T773 T772 pobj Sox6,for
R542 T774 T771 prep in,role
R543 T775 T777 amod erythroid,maturation
R544 T776 T777 compound cell,maturation
R545 T777 T774 pobj maturation,in
R546 T778 T755 punct .,shows
R547 T779 T787 advmod Thus,provide
R548 T780 T787 punct ",",provide
R549 T781 T782 amod Sox6,regulation
R550 T782 T787 nsubj regulation,provide
R551 T783 T782 prep of,regulation
R552 T784 T785 amod ɛy,globin
R553 T785 T783 pobj globin,of
R554 T786 T787 aux might,provide
R555 T787 T787 ROOT provide,provide
R556 T788 T789 det a,novel
R557 T789 T787 dobj novel,provide
R558 T790 T791 amod therapeutical,target
R559 T791 T789 appos target,novel
R560 T792 T787 prep in,provide
R561 T793 T794 det the,treatment
R562 T794 T792 pobj treatment,in
R563 T795 T794 prep of,treatment
R564 T796 T795 pobj hemoglobinopathies,of
R565 T797 T798 amod such,as
R566 T798 T796 prep as,hemoglobinopathies
R567 T799 T800 compound sickle,cell
R568 T800 T801 compound cell,anemia
R569 T801 T798 pobj anemia,as
R570 T802 T801 cc and,anemia
R571 T803 T801 conj thalassemia,anemia
R572 T804 T787 punct .,provide

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T230 1157-1167 Regulation denotes regulation
T229 1171-1180 Protein denotes ɛy globin
T228 1152-1156 Protein denotes Sox6
T227 1022-1030 Positive_regulation denotes required
T225 1111-1115 Protein denotes Sox6
T224 1051-1057 Protein denotes globin
T223 1014-1018 Protein denotes Sox6
T222 814-824 Gene_expression denotes expression
T221 940-944 Protein denotes Sox6
T220 894-899 Protein denotes p100H
T219 828-832 Protein denotes Sox6
T218 775-782 Binding denotes binding
T217 793-801 Entity denotes promoter
T216 738-742 Protein denotes Sox6
T215 603-607 Protein denotes Sox6
T214 378-387 Gene_expression denotes expressed
T213 378-387 Gene_expression denotes expressed
T212 328-337 Negative_regulation denotes deficient
T211 352-361 Protein denotes ɛy globin
T210 345-350 Protein denotes p100H
T209 323-327 Protein denotes Sox6
T208 225-229 Protein denotes Sox6
T207 64-71 Negative_regulation denotes defined
T206 64-71 Negative_regulation denotes defined
T205 127-133 Entity denotes domain
T204 183-186 Protein denotes Sry
T203 24-55 Protein denotes Sox transcription factor family
T202 0-4 Protein denotes Sox6
T226 1035-1044 Negative_regulation denotes silencing
R28 T202 T206 themeOf Sox6,defined
R29 T203 T207 themeOf Sox transcription factor family,defined
R30 T204 T205 partOf Sry,domain
R31 T205 T206 Site domain,defined
R32 T205 T207 Site domain,defined
R33 T209 T212 themeOf Sox6,deficient
R34 T210 T213 themeOf p100H,expressed
R35 T211 T214 themeOf ɛy globin,expressed
R36 T216 T218 themeOf Sox6,binding
R37 T217 T218 Site promoter,binding
R38 T219 T222 themeOf Sox6,expression
R39 T223 T227 causeOf Sox6,required
R40 T224 T226 themeOf globin,silencing
R41 T228 T230 themeOf Sox6,regulation
R445 T226 T227 themeOf silencing,required

testone

Id Subject Object Predicate Lexical cue
T22 0-4 Protein denotes Sox6
T23 183-186 Protein denotes Sry
T24 225-229 Protein denotes Sox6
T25 323-327 Protein denotes Sox6
T26 352-361 Protein denotes ɛy globin
T27 561-563 Protein denotes ɛy
T28 603-607 Protein denotes Sox6
T29 738-742 Protein denotes Sox6
T30 790-792 Protein denotes ɛy
T31 828-832 Protein denotes Sox6
T32 888-890 Protein denotes ɛy
T33 940-944 Protein denotes Sox6
T34 1014-1018 Protein denotes Sox6
T35 1048-1057 Protein denotes ɛy globin
T36 1111-1115 Protein denotes Sox6
T37 1152-1156 Protein denotes Sox6
T38 1171-1180 Protein denotes ɛy globin
T40 328-337 Negative_regulation denotes deficient
T41 378-387 Gene_expression denotes expressed
T42 775-782 Binding denotes binding
T43 793-801 Entity denotes promoter
T44 1157-1167 Regulation denotes regulation
R5 T37 T44 causeOf Sox6,regulation
R6 T38 T44 themeOf ɛy globin,regulation
R7 T43 T30 partOf promoter,ɛy
R8 T43 T42 themeOf promoter,binding
R2 T25 T40 themeOf Sox6,deficient
R3 T26 T41 themeOf ɛy globin,expressed
R4 T29 T42 themeOf Sox6,binding

test3

Id Subject Object Predicate Lexical cue
T47 0-4 Protein denotes Sox6
T85 1171-1180 Protein denotes ɛy globin
T84 1152-1156 Protein denotes Sox6
T83 1111-1115 Protein denotes Sox6
T82 1048-1057 Protein denotes ɛy globin
T48 183-186 Protein denotes Sry
T49 225-229 Protein denotes Sox6
T50 323-327 Protein denotes Sox6
T51 352-361 Protein denotes ɛy globin
T52 561-563 Protein denotes ɛy
T53 603-607 Protein denotes Sox6
T54 738-742 Protein denotes Sox6
T55 790-792 Protein denotes ɛy
T56 828-832 Protein denotes Sox6
T57 888-890 Protein denotes ɛy
T58 940-944 Protein denotes Sox6
T59 1014-1018 Protein denotes Sox6
T60 1048-1057 Protein denotes ɛy globin
T61 1111-1115 Protein denotes Sox6
T62 1152-1156 Protein denotes Sox6
T63 1171-1180 Protein denotes ɛy globin
T67 0-4 Protein denotes Sox6
T68 183-186 Protein denotes Sry
T69 225-229 Protein denotes Sox6
T70 323-327 Protein denotes Sox6
T71 352-361 Protein denotes ɛy globin
T72 378-387 Gene_expression denotes expressed
T73 561-563 Protein denotes ɛy
T74 603-607 Protein denotes Sox6
T75 738-742 Protein denotes Sox6
T76 775-782 Binding denotes binding
T77 790-792 Protein denotes ɛy
T78 828-832 Protein denotes Sox6
T79 888-890 Protein denotes ɛy
T80 940-944 Protein denotes Sox6
T81 1014-1018 Protein denotes Sox6
R12 T71 T72 themeOf ɛy globin,expressed
R13 T74 T73 themeOf Sox6,ɛy
R14 T75 T76 themeOf Sox6,binding
R15 T77 T76 themeOf ɛy,binding
R16 T82 T81 themeOf ɛy globin,Sox6
R17 T83 T81 themeOf Sox6,Sox6
R18 T85 T84 themeOf ɛy globin,Sox6