PMC:1359071 / 47151-48803 JSONTXT

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As before, multiple testing was addressed with use of the FDR, ranking the p-values obtained from the above F tests and setting α = 0.01.\nGenes correlated with the gonadal fat mass trait generated several significant eQTLs. In order to determine if eQTLs generated by these genes were enriched in any locus or if they were distributed randomly, we compared the distribution of these eQTLs against the distribution of all liver eQTLs in overlapping 6-cM bins across the genome using the Fisher exact test. This test is based on exact probabilities from a specific distribution (hypergeometric distribution). p-Values obtained from this test were corrected for multiple comparisons using a simple Bonferonni correction (given that we performed 772 tests across the genome, 0.05/772). Loci with p \u003c 6.5 × 10−5 by Fisher exact test were considered significantly enriched for eQTLs correlated with gonadal fat 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