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    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T13651","span":{"begin":61,"end":66},"obj":"SO:0000704"},{"id":"T13652","span":{"begin":94,"end":104},"obj":"SO:0000673"},{"id":"T13653","span":{"begin":105,"end":115},"obj":"GO:0010467"},{"id":"T13654","span":{"begin":228,"end":233},"obj":"SO:0000704"},{"id":"T13655","span":{"begin":329,"end":334},"obj":"SO:0000704"},{"id":"T13656","span":{"begin":418,"end":422},"obj":"SO:0000704"},{"id":"T13657","span":{"begin":439,"end":452},"obj":"GO:0006412"},{"id":"T13658","span":{"begin":517,"end":526},"obj":"GO:0065007"},{"id":"T13659","span":{"begin":679,"end":684},"obj":"UBERON:0000062"},{"id":"T13660","span":{"begin":694,"end":698},"obj":"SO:0000704"},{"id":"T13661","span":{"begin":694,"end":709},"obj":"GO:0010467"},{"id":"T13662","span":{"begin":777,"end":781},"obj":"SO:0000704"},{"id":"T13663","span":{"begin":789,"end":795},"obj":"UBERON:0000479"},{"id":"T13664","span":{"begin":815,"end":821},"obj":"UBERON:0000479"},{"id":"T13665","span":{"begin":832,"end":839},"obj":"GO:0065007"},{"id":"T13666","span":{"begin":902,"end":916},"obj":"UBERON:0001013"},{"id":"T13667","span":{"begin":932,"end":942},"obj":"GO:0065007"},{"id":"T13668","span":{"begin":955,"end":962},"obj":"UBERON:0000479"},{"id":"T13669","span":{"begin":1003,"end":1008},"obj":"SO:0000704"}],"text":"One shortcoming of this approach, however, is that candidate genes are limited to those whose transcript expression levels vary in association with a nearby polymorphism that differs between the parental strains—in other words, genes with significant and detectable cis-eQTLs. However, it is not strictly necessary for candidate genes to have evidence of such linkage: polymorphisms underlying a trait cQTL can affect gene function or posttranslational modifications. Nevertheless, several phenotypes are known to be regulated, at least partly, at the level of transcription or mRNA stability, which is exactly what our methods are designed to detect. A separate problem is that organ-specific gene expression differences may preclude one from detecting the relevant causative gene if the tissue arrayed is not the tissue where the control is exerted. This is particularly relevant for a trait such as adipose tissue mass, which is controlled by multiple tissues. We propose that analysis of correlated genes can provide guidance as discussed below."}

    craft-ca-core-ex-dev

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    craft-sa-dev

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