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PMC:1359071 / 2823-6158 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
16462940-11861025-86014481 131-132 11861025 denotes 1
16462940-14596945-86014482 133-134 14596945 denotes 2
16462940-11328966-86014483 1364-1365 11328966 denotes 3
16462940-12925895-86014483 1364-1365 12925895 denotes 3
16462940-12646919-86014483 1364-1365 12646919 denotes 3
16462940-15514660-86014484 1643-1644 15514660 denotes 6
16462940-14634638-86014485 2103-2104 14634638 denotes 7
16462940-12646919-86014486 2112-2113 12646919 denotes 5
16462940-15514893-86014487 2114-2115 15514893 denotes 8
16462940-11923494-86014488 2130-2131 11923494 denotes 9
16462940-15299141-86014488 2130-2131 15299141 denotes 9
16462940-15687266-86014488 2130-2131 15687266 denotes 9
16462940-15711547-86014488 2130-2131 15711547 denotes 9
16462940-15711545-86014488 2130-2131 15711545 denotes 9
16462940-15711544-86014488 2130-2131 15711544 denotes 9
16462940-15269782-86014488 2130-2131 15269782 denotes 9
16462940-12415114-86014488 2130-2131 12415114 denotes 9
T54173 131-132 11861025 denotes 1
T38470 133-134 14596945 denotes 2
T34552 1364-1365 11328966 denotes 3
T49441 1364-1365 12925895 denotes 3
T29806 1364-1365 12646919 denotes 3
T42793 1643-1644 15514660 denotes 6
T65566 2103-2104 14634638 denotes 7
T6696 2112-2113 12646919 denotes 5
T30843 2114-2115 15514893 denotes 8
T59192 2130-2131 11923494 denotes 9
T9450 2130-2131 15299141 denotes 9
T64174 2130-2131 15687266 denotes 9
T72429 2130-2131 15711547 denotes 9
T25873 2130-2131 15711545 denotes 9
T67278 2130-2131 15711544 denotes 9
T90746 2130-2131 15269782 denotes 9
T76675 2130-2131 12415114 denotes 9

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T1865 54-61 SO:0000704 denotes genetic
T1866 193-201 UBERON:0000002 denotes cervical
T1867 205-213 UBERON:0002367 denotes prostate
T1868 426-433 PR:000045358 denotes insulin
T1869 568-575 SO:0000704 denotes genetic
T1870 634-641 SO:0000704 denotes genetic
T1871 660-665 SO:0000704 denotes genic
T1872 705-712 SO:0000704 denotes genetic
T1873 853-857 SO:0000704 denotes gene
T1874 853-868 GO:0010467 denotes gene expression
T1875 983-988 SO:0000704 denotes genes
T1876 1025-1035 GO:0010467 denotes expression
T1877 1282-1287 NCBITaxon:10088 denotes mouse
T1878 1331-1340 GO:0008152 denotes metabolic
T1879 1438-1443 SO:0000704 denotes genes
T1880 1479-1486 SO:0000704 denotes genetic
T1881 1516-1523 SO:0000704 denotes genetic
T1882 1554-1566 SO:0000704 denotes genetic loci
T1883 1715-1720 NCBITaxon:9606 denotes human
T1884 1738-1745 SO:0000704 denotes genetic
T1885 1777-1782 NCBITaxon:10088 denotes mouse
T1886 1874-1880 SO:0001026 denotes genome
T1887 1901-1925 SO:0000771 denotes quantitative trait locus
T1888 1927-1930 SO:0000771 denotes QTL
T1889 2011-2018 SO:0000704 denotes genetic
T1890 2093-2097 SO:0000771 denotes QTLs
T1891 2204-2210 SO:0001026 denotes genome
T1892 2216-2220 SO:0000704 denotes gene
T1893 2216-2231 GO:0010467 denotes gene expression
T1894 2290-2294 SO:0000704 denotes gene
T1895 2290-2305 GO:0010467 denotes gene expression
T1896 2395-2402 SO:0000704 denotes genetic
T1897 2403-2413 GO:0065007 denotes regulation
T1898 2515-2519 SO:0000704 denotes gene
T1899 2620-2627 SO:0000704 denotes genetic
T1901 2671-2684,2691-2706 GO:0010468 denotes regulation of gene expression
T1902 2685-2690 UBERON:0002107 denotes liver
T1903 2691-2695 SO:0000704 denotes gene
T1904 2797-2811 CHEBI:39015 denotes apolipoprotein
T1905 2797-2813 PR:000004155 denotes apolipoprotein E
T1906 2820-2824 PR:000004155 denotes ApoE
T1907 2849-2853 PR:000004155 denotes ApoE
T1908 2953-2962 GO:0008152 denotes metabolic
T1909 2999-3006 NCBITaxon:33208 denotes animals
T1910 3077-3081 SO:0000771 denotes QTLs
T1911 3119-3123 SO:0000704 denotes gene
T1912 3119-3134 GO:0010467 denotes gene expression
T1913 3135-3139 SO:0000771 denotes QTLs
T1914 3238-3245 SO:0000704 denotes genetic
T1915 3246-3256 GO:0065007 denotes regulation
T1916 3264-3271 UBERON:0000991 denotes gonadal
T1917 3303-3308 SO:0000704 denotes genes

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T1918 13-20 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Females
T1919 25-30 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1920 54-61 SO_EXT:0000704 denotes genetic
T1921 193-201 UBERON:0000002 denotes cervical
T1922 205-213 UBERON:0002367 denotes prostate
T1923 309-314 NCBITaxon_UBERON_EXT:woman denotes women
T1924 426-433 PR_EXT:000045358 denotes insulin
T1925 525-535 GO_PATO_EXT:biological_behavior denotes behavioral
T1926 568-575 SO_EXT:0000704 denotes genetic
T1927 634-641 SO_EXT:0000704 denotes genetic
T1928 660-665 SO_EXT:0000704 denotes genic
T1929 705-712 SO_EXT:0000704 denotes genetic
T1930 713-722 SO_EXT:sequence_variation_entity_or_quality denotes variation
T1931 853-857 SO_EXT:0000704 denotes gene
T1932 853-868 GO:0010467 denotes gene expression
T1933 935-942 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Females
T1934 947-952 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1935 983-988 SO_EXT:0000704 denotes genes
T1936 1025-1035 GO:0010467 denotes expression
T1937 1169-1182 SO_EXT:polymorphism denotes polymorphisms
T1938 1183-1192 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T1939 1282-1287 NCBITaxon:10088 denotes mouse
T1940 1319-1327 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T1941 1331-1340 GO:0008152 denotes metabolic
T1942 1345-1353 UBERON_EXT:vascular_system_or_vasculature_or_vessel denotes vascular
T1943 1420-1427 SO_EXT:sequence_altered_entity denotes mutants
T1944 1438-1443 SO_EXT:0000704 denotes genes
T1945 1479-1486 SO_EXT:0000704 denotes genetic
T1946 1487-1496 SO_EXT:sequence_variation_entity_or_quality denotes variation
T1947 1516-1523 SO_EXT:0000704 denotes genetic
T1948 1554-1566 SO_EXT:0000704 denotes genetic loci
T1949 1597-1607 SO_EXT:sequence_variation_entity_or_quality denotes variations
T1950 1715-1720 NCBITaxon:9606 denotes human
T1951 1738-1745 SO_EXT:0000704 denotes genetic
T1952 1777-1782 NCBITaxon:10088 denotes mouse
T1953 1874-1880 SO_EXT:0001026 denotes genome
T1954 1901-1925 SO_EXT:0000771 denotes quantitative trait locus
T1955 1927-1930 SO_EXT:0000771 denotes QTL
T1956 1976-1995 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomal regions
T1957 2011-2018 SO_EXT:0000704 denotes genetic
T1958 2019-2028 SO_EXT:sequence_variation_entity_or_quality denotes variation
T1959 2093-2097 SO_EXT:0000771 denotes QTLs
T1960 2204-2210 SO_EXT:0001026 denotes genome
T1961 2216-2220 SO_EXT:0000704 denotes gene
T1962 2216-2231 GO:0010467 denotes gene expression
T1963 2278-2286 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T1964 2290-2294 SO_EXT:0000704 denotes gene
T1965 2290-2305 GO:0010467 denotes gene expression
T1966 2395-2402 SO_EXT:0000704 denotes genetic
T1967 2403-2413 GO:0065007 denotes regulation
T1968 2515-2519 SO_EXT:0000704 denotes gene
T1969 2620-2627 SO_EXT:0000704 denotes genetic
T1971 2671-2684,2691-2706 GO:0010468 denotes regulation of gene expression
T1972 2685-2690 UBERON:0002107 denotes liver
T1973 2691-2695 SO_EXT:0000704 denotes gene
T1974 2797-2811 CHEBI:39015 denotes apolipoprotein
T1975 2797-2813 PR_EXT:000004155 denotes apolipoprotein E
T1976 2814-2818 SO_EXT:sequence_nullness denotes null
T1977 2820-2824 PR_EXT:000004155 denotes ApoE
T1978 2824-2825 SO_EXT:sequence_nullness_or_absence denotes −
T1979 2826-2827 SO_EXT:sequence_nullness_or_absence denotes −
T1980 2849-2853 PR_EXT:000004155 denotes ApoE
T1981 2853-2854 SO_EXT:sequence_nullness_or_absence denotes −
T1982 2855-2856 SO_EXT:sequence_nullness_or_absence denotes −
T1983 2953-2962 GO:0008152 denotes metabolic
T1984 2999-3006 NCBITaxon:33208 denotes animals
T1985 3077-3081 SO_EXT:0000771 denotes QTLs
T1986 3119-3123 SO_EXT:0000704 denotes gene
T1987 3119-3134 GO:0010467 denotes gene expression
T1988 3135-3139 SO_EXT:0000771 denotes QTLs
T1989 3238-3245 SO_EXT:0000704 denotes genetic
T1990 3246-3256 GO:0065007 denotes regulation
T1991 3264-3271 UBERON:0000991 denotes gonadal
T1992 3272-3275 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T1993 3303-3308 SO_EXT:0000704 denotes genes

craft-sa-dev

Id Subject Object Predicate Lexical cue
T1994 13-20 NNS denotes Females
T1995 31-36 VBP denotes share
T1996 21-24 CC denotes and
T1997 25-30 NNS denotes males
T1998 37-43 RB denotes nearly
T1999 44-53 JJ denotes identical
T2000 62-73 NN denotes information
T2001 54-61 JJ denotes genetic
T2002 73-75 , denotes ,
T2003 75-78 CC denotes but
T2004 79-83 VBP denotes vary
T2005 84-90 RB denotes widely
T2006 91-95 IN denotes with
T2007 96-103 NN denotes respect
T2008 104-106 IN denotes to
T2009 107-114 NN denotes disease
T2010 115-129 NN denotes susceptibility
T2011 130-131 -LRB- denotes [
T2012 133-134 CD denotes 2
T2013 131-132 CD denotes 1
T2014 132-133 , denotes ,
T2015 134-135 -RRB- denotes ]
T2016 135-136 . denotes .
T2017 136-445 sentence denotes Apart from the obvious gender-specific diseases such as cervical or prostate cancer, sex influences susceptibility to nearly all highly prevalent diseases that affect both women and men, including atherosclerosis and diabetes and their precursor conditions of hyperlipidemia, obesity, and insulin resistance.
T2018 137-142 RB denotes Apart
T2019 226-236 VBZ denotes influences
T2020 143-147 IN denotes from
T2021 148-151 DT denotes the
T2022 176-184 NNS denotes diseases
T2023 152-159 JJ denotes obvious
T2024 160-166 NN denotes gender
T2025 167-175 JJ denotes specific
T2026 166-167 HYPH denotes -
T2027 185-189 JJ denotes such
T2028 190-192 IN denotes as
T2029 193-201 JJ denotes cervical
T2030 214-220 NN denotes cancer
T2031 202-204 CC denotes or
T2032 205-213 NN denotes prostate
T2033 220-222 , denotes ,
T2034 222-225 NN denotes sex
T2035 237-251 NN denotes susceptibility
T2036 252-254 IN denotes to
T2037 255-261 RB denotes nearly
T2038 262-265 DT denotes all
T2039 283-291 NNS denotes diseases
T2040 266-272 RB denotes highly
T2041 273-282 JJ denotes prevalent
T2042 292-296 WDT denotes that
T2043 297-303 VBP denotes affect
T2044 304-308 DT denotes both
T2045 309-314 NNS denotes women
T2046 315-318 CC denotes and
T2047 319-322 NNS denotes men
T2048 322-324 , denotes ,
T2049 324-333 VBG denotes including
T2050 334-349 NN denotes atherosclerosis
T2051 350-353 CC denotes and
T2052 354-362 NN denotes diabetes
T2053 363-366 CC denotes and
T2054 367-372 PRP$ denotes their
T2055 383-393 NNS denotes conditions
T2056 373-382 NN denotes precursor
T2057 394-396 IN denotes of
T2058 397-411 NN denotes hyperlipidemia
T2059 411-413 , denotes ,
T2060 413-420 NN denotes obesity
T2061 420-422 , denotes ,
T2062 422-425 CC denotes and
T2063 426-433 NN denotes insulin
T2064 434-444 NN denotes resistance
T2065 444-445 . denotes .
T2066 445-629 sentence denotes These are multifactorial in their pathogenesis, encompassing environmental and behavioral aspects, as well as significant genetic determination, on which these other factors interact.
T2067 446-451 DT denotes These
T2068 452-455 VBP denotes are
T2069 456-470 JJ denotes multifactorial
T2070 471-473 IN denotes in
T2071 474-479 PRP$ denotes their
T2072 480-492 NN denotes pathogenesis
T2073 492-494 , denotes ,
T2074 494-506 VBG denotes encompassing
T2075 507-520 JJ denotes environmental
T2076 536-543 NNS denotes aspects
T2077 521-524 CC denotes and
T2078 525-535 JJ denotes behavioral
T2079 543-545 , denotes ,
T2080 545-547 RB denotes as
T2081 553-555 IN denotes as
T2082 548-552 RB denotes well
T2083 556-567 JJ denotes significant
T2084 576-589 NN denotes determination
T2085 568-575 JJ denotes genetic
T2086 589-591 , denotes ,
T2087 591-593 IN denotes on
T2088 620-628 VBP denotes interact
T2089 594-599 WDT denotes which
T2090 600-605 DT denotes these
T2091 612-619 NNS denotes factors
T2092 606-611 JJ denotes other
T2093 628-629 . denotes .
T2094 629-751 sentence denotes The genetic component is multigenic, with the heritability embedded in the genetic variation intrinsic to our population.
T2095 630-633 DT denotes The
T2096 642-651 NN denotes component
T2097 634-641 JJ denotes genetic
T2098 652-654 VBZ denotes is
T2099 655-665 JJ denotes multigenic
T2100 665-667 , denotes ,
T2101 667-671 IN denotes with
T2102 672-675 DT denotes the
T2103 676-688 NN denotes heritability
T2104 689-697 VBN denotes embedded
T2105 698-700 IN denotes in
T2106 701-704 DT denotes the
T2107 713-722 NN denotes variation
T2108 705-712 JJ denotes genetic
T2109 723-732 JJ denotes intrinsic
T2110 733-735 IN denotes to
T2111 736-739 PRP$ denotes our
T2112 740-750 NN denotes population
T2113 750-751 . denotes .
T2114 751-934 sentence denotes Although the sex differences in disease susceptibility are recognized, the interplay between sex and gene expression that is at the basis of these differences is not well understood.
T2115 752-760 IN denotes Although
T2116 811-821 VBN denotes recognized
T2117 761-764 DT denotes the
T2118 769-780 NNS denotes differences
T2119 765-768 NN denotes sex
T2120 781-783 IN denotes in
T2121 784-791 NN denotes disease
T2122 792-806 NN denotes susceptibility
T2123 807-810 VBP denotes are
T2124 911-913 VBZ denotes is
T2125 821-823 , denotes ,
T2126 823-826 DT denotes the
T2127 827-836 NN denotes interplay
T2128 837-844 IN denotes between
T2129 845-848 NN denotes sex
T2130 849-852 CC denotes and
T2131 853-857 NN denotes gene
T2132 858-868 NN denotes expression
T2133 869-873 WDT denotes that
T2134 874-876 VBZ denotes is
T2135 877-879 IN denotes at
T2136 880-883 DT denotes the
T2137 884-889 NN denotes basis
T2138 890-892 IN denotes of
T2139 893-898 DT denotes these
T2140 899-910 NNS denotes differences
T2141 914-917 RB denotes not
T2142 918-922 RB denotes well
T2143 923-933 JJ denotes understood
T2144 933-934 . denotes .
T2145 934-1084 sentence denotes Females and males inherit (on average) the same genes that may be risk factors, but their expression and effect on disease risk varies significantly.
T2146 935-942 NNS denotes Females
T2147 953-960 VBP denotes inherit
T2148 943-946 CC denotes and
T2149 947-952 NNS denotes males
T2150 961-962 -LRB- denotes (
T2151 962-964 IN denotes on
T2152 965-972 JJ denotes average
T2153 972-973 -RRB- denotes )
T2154 974-977 DT denotes the
T2155 983-988 NNS denotes genes
T2156 978-982 JJ denotes same
T2157 989-993 WDT denotes that
T2158 998-1000 VB denotes be
T2159 994-997 MD denotes may
T2160 1001-1005 NN denotes risk
T2161 1006-1013 NNS denotes factors
T2162 1013-1015 , denotes ,
T2163 1015-1018 CC denotes but
T2164 1019-1024 PRP$ denotes their
T2165 1025-1035 NN denotes expression
T2166 1063-1069 VBZ denotes varies
T2167 1036-1039 CC denotes and
T2168 1040-1046 NN denotes effect
T2169 1047-1049 IN denotes on
T2170 1050-1057 NN denotes disease
T2171 1058-1062 NN denotes risk
T2172 1070-1083 RB denotes significantly
T2173 1083-1084 . denotes .
T2174 1084-1260 sentence denotes An understanding and recognition of the significance of specific disease-associated polymorphisms/mutations in the context of sex is therefore of critical clinical importance.
T2175 1085-1087 DT denotes An
T2176 1088-1101 NN denotes understanding
T2177 1215-1217 VBZ denotes is
T2178 1102-1105 CC denotes and
T2179 1106-1117 NN denotes recognition
T2180 1118-1120 IN denotes of
T2181 1121-1124 DT denotes the
T2182 1125-1137 NN denotes significance
T2183 1138-1140 IN denotes of
T2184 1141-1149 JJ denotes specific
T2185 1183-1192 NNS denotes mutations
T2186 1150-1157 NN denotes disease
T2187 1158-1168 VBN denotes associated
T2188 1157-1158 HYPH denotes -
T2189 1169-1182 NNS denotes polymorphisms
T2190 1182-1183 HYPH denotes /
T2191 1193-1195 IN denotes in
T2192 1196-1199 DT denotes the
T2193 1200-1207 NN denotes context
T2194 1208-1210 IN denotes of
T2195 1211-1214 NN denotes sex
T2196 1218-1227 RB denotes therefore
T2197 1228-1230 IN denotes of
T2198 1231-1239 JJ denotes critical
T2199 1249-1259 NN denotes importance
T2200 1240-1248 JJ denotes clinical
T2201 1259-1260 . denotes .
T2202 1260-1369 sentence denotes We have utilized the mouse as a model system to study the genetics of metabolic and vascular diseases [3–5].
T2203 1261-1263 PRP denotes We
T2204 1269-1277 VBN denotes utilized
T2205 1264-1268 VBP denotes have
T2206 1278-1281 DT denotes the
T2207 1282-1287 NN denotes mouse
T2208 1288-1290 IN denotes as
T2209 1291-1292 DT denotes a
T2210 1299-1305 NN denotes system
T2211 1293-1298 NN denotes model
T2212 1306-1308 TO denotes to
T2213 1309-1314 VB denotes study
T2214 1315-1318 DT denotes the
T2215 1319-1327 NN denotes genetics
T2216 1328-1330 IN denotes of
T2217 1331-1340 JJ denotes metabolic
T2218 1354-1362 NNS denotes diseases
T2219 1341-1344 CC denotes and
T2220 1345-1353 JJ denotes vascular
T2221 1363-1364 -LRB- denotes [
T2222 1364-1365 CD denotes 3
T2223 1365-1366 SYM denotes –
T2224 1366-1367 CD denotes 5
T2225 1367-1368 -RRB- denotes ]
T2226 1368-1369 . denotes .
T2227 1369-1646 sentence denotes Rather than focus initially on natural or induced mutants of single genes, we utilize the complex endogenous genetic variation between strains in genetic crosses to identify causative genetic loci and ultimately the underlying variations responsible for trait differences [6].
T2228 1370-1376 RB denotes Rather
T2229 1448-1455 VBP denotes utilize
T2230 1377-1381 IN denotes than
T2231 1382-1387 VBP denotes focus
T2232 1388-1397 RB denotes initially
T2233 1398-1400 IN denotes on
T2234 1401-1408 JJ denotes natural
T2235 1420-1427 NNS denotes mutants
T2236 1409-1411 CC denotes or
T2237 1412-1419 VBN denotes induced
T2238 1428-1430 IN denotes of
T2239 1431-1437 JJ denotes single
T2240 1438-1443 NNS denotes genes
T2241 1443-1445 , denotes ,
T2242 1445-1447 PRP denotes we
T2243 1456-1459 DT denotes the
T2244 1487-1496 NN denotes variation
T2245 1460-1467 JJ denotes complex
T2246 1468-1478 JJ denotes endogenous
T2247 1479-1486 JJ denotes genetic
T2248 1497-1504 IN denotes between
T2249 1505-1512 NNS denotes strains
T2250 1513-1515 IN denotes in
T2251 1516-1523 JJ denotes genetic
T2252 1524-1531 NNS denotes crosses
T2253 1532-1534 TO denotes to
T2254 1535-1543 VB denotes identify
T2255 1544-1553 JJ denotes causative
T2256 1562-1566 NNS denotes loci
T2257 1554-1561 JJ denotes genetic
T2258 1567-1570 CC denotes and
T2259 1571-1581 RB denotes ultimately
T2260 1597-1607 NNS denotes variations
T2261 1582-1585 DT denotes the
T2262 1586-1596 VBG denotes underlying
T2263 1608-1619 JJ denotes responsible
T2264 1620-1623 IN denotes for
T2265 1624-1629 NN denotes trait
T2266 1630-1641 NNS denotes differences
T2267 1642-1643 -LRB- denotes [
T2268 1643-1644 CD denotes 6
T2269 1644-1645 -RRB- denotes ]
T2270 1645-1646 . denotes .
T2271 1646-1733 sentence denotes This design more closely reflects the situation faced when studying human populations.
T2272 1647-1651 DT denotes This
T2273 1652-1658 NN denotes design
T2274 1672-1680 VBZ denotes reflects
T2275 1659-1663 RBR denotes more
T2276 1664-1671 RB denotes closely
T2277 1681-1684 DT denotes the
T2278 1685-1694 NN denotes situation
T2279 1695-1700 VBN denotes faced
T2280 1701-1705 WRB denotes when
T2281 1706-1714 VBG denotes studying
T2282 1715-1720 JJ denotes human
T2283 1721-1732 NNS denotes populations
T2284 1732-1733 . denotes .
T2285 1733-1881 sentence denotes The genetic composition of each individual mouse is restricted to that of the two parental strains and is defined at every locus across the genome.
T2286 1734-1737 DT denotes The
T2287 1746-1757 NN denotes composition
T2288 1738-1745 JJ denotes genetic
T2289 1786-1796 VBN denotes restricted
T2290 1758-1760 IN denotes of
T2291 1761-1765 DT denotes each
T2292 1777-1782 NN denotes mouse
T2293 1766-1776 JJ denotes individual
T2294 1783-1785 VBZ denotes is
T2295 1797-1799 IN denotes to
T2296 1800-1804 DT denotes that
T2297 1805-1807 IN denotes of
T2298 1808-1811 DT denotes the
T2299 1825-1832 NNS denotes strains
T2300 1812-1815 CD denotes two
T2301 1816-1824 JJ denotes parental
T2302 1833-1836 CC denotes and
T2303 1837-1839 VBZ denotes is
T2304 1840-1847 VBN denotes defined
T2305 1848-1850 IN denotes at
T2306 1851-1856 DT denotes every
T2307 1857-1862 NN denotes locus
T2308 1863-1869 IN denotes across
T2309 1870-1873 DT denotes the
T2310 1874-1880 NN denotes genome
T2311 1880-1881 . denotes .
T2312 1881-2107 sentence denotes The application of quantitative trait locus (QTL) analysis allows the identification of those chromosomal regions that contain a genetic variation that influences trait expression (for a comprehensive review on QTLs see [7]).
T2313 1882-1885 DT denotes The
T2314 1886-1897 NN denotes application
T2315 1941-1947 VBZ denotes allows
T2316 1898-1900 IN denotes of
T2317 1901-1913 JJ denotes quantitative
T2318 1914-1919 NN denotes trait
T2319 1920-1925 NN denotes locus
T2320 1932-1940 NN denotes analysis
T2321 1926-1927 -LRB- denotes (
T2322 1927-1930 NN denotes QTL
T2323 1930-1931 -RRB- denotes )
T2324 1948-1951 DT denotes the
T2325 1952-1966 NN denotes identification
T2326 1967-1969 IN denotes of
T2327 1970-1975 DT denotes those
T2328 1988-1995 NNS denotes regions
T2329 1976-1987 JJ denotes chromosomal
T2330 1996-2000 WDT denotes that
T2331 2001-2008 VBP denotes contain
T2332 2009-2010 DT denotes a
T2333 2019-2028 NN denotes variation
T2334 2011-2018 JJ denotes genetic
T2335 2029-2033 WDT denotes that
T2336 2034-2044 VBZ denotes influences
T2337 2045-2050 NN denotes trait
T2338 2051-2061 NN denotes expression
T2339 2062-2063 -LRB- denotes (
T2340 2098-2101 VBP denotes see
T2341 2063-2066 IN denotes for
T2342 2067-2068 DT denotes a
T2343 2083-2089 NN denotes review
T2344 2069-2082 JJ denotes comprehensive
T2345 2090-2092 IN denotes on
T2346 2093-2097 NNS denotes QTLs
T2347 2102-2103 -LRB- denotes [
T2348 2103-2104 CD denotes 7
T2349 2104-2105 -RRB- denotes ]
T2350 2105-2106 -RRB- denotes )
T2351 2106-2107 . denotes .
T2352 2107-2329 sentence denotes We [5,8], and others [9–17], have recently extended the power of this approach by incorporating genome-wide gene expression array analysis, which allows us to model the “genetics of gene expression” using similar methods.
T2353 2108-2110 PRP denotes We
T2354 2151-2159 VBN denotes extended
T2355 2111-2112 -LRB- denotes [
T2356 2114-2115 CD denotes 8
T2357 2112-2113 CD denotes 5
T2358 2113-2114 , denotes ,
T2359 2115-2116 -RRB- denotes ]
T2360 2116-2118 , denotes ,
T2361 2118-2121 CC denotes and
T2362 2122-2128 NNS denotes others
T2363 2129-2130 -LRB- denotes [
T2364 2130-2131 CD denotes 9
T2365 2131-2132 SYM denotes –
T2366 2132-2134 CD denotes 17
T2367 2134-2135 -RRB- denotes ]
T2368 2135-2137 , denotes ,
T2369 2137-2141 VBP denotes have
T2370 2142-2150 RB denotes recently
T2371 2160-2163 DT denotes the
T2372 2164-2169 NN denotes power
T2373 2170-2172 IN denotes of
T2374 2173-2177 DT denotes this
T2375 2178-2186 NN denotes approach
T2376 2187-2189 IN denotes by
T2377 2190-2203 VBG denotes incorporating
T2378 2204-2210 NN denotes genome
T2379 2211-2215 JJ denotes wide
T2380 2210-2211 HYPH denotes -
T2381 2238-2246 NN denotes analysis
T2382 2216-2220 NN denotes gene
T2383 2221-2231 NN denotes expression
T2384 2232-2237 NN denotes array
T2385 2246-2248 , denotes ,
T2386 2248-2253 WDT denotes which
T2387 2254-2260 VBZ denotes allows
T2388 2261-2263 PRP denotes us
T2389 2267-2272 VB denotes model
T2390 2264-2266 TO denotes to
T2391 2273-2276 DT denotes the
T2392 2278-2286 NN denotes genetics
T2393 2277-2278 `` denotes “
T2394 2287-2289 IN denotes of
T2395 2290-2294 NN denotes gene
T2396 2295-2305 NN denotes expression
T2397 2305-2306 '' denotes ”
T2398 2307-2312 VBG denotes using
T2399 2313-2320 JJ denotes similar
T2400 2321-2328 NNS denotes methods
T2401 2328-2329 . denotes .
T2402 2329-2520 sentence denotes An immediate extension of this approach is toward dissecting the genetic regulation of complex phenotypes, which would greatly improve the progression from candidate locus to candidate gene.
T2403 2330-2332 DT denotes An
T2404 2343-2352 NN denotes extension
T2405 2333-2342 JJ denotes immediate
T2406 2370-2372 VBZ denotes is
T2407 2353-2355 IN denotes of
T2408 2356-2360 DT denotes this
T2409 2361-2369 NN denotes approach
T2410 2373-2379 IN denotes toward
T2411 2380-2390 VBG denotes dissecting
T2412 2391-2394 DT denotes the
T2413 2403-2413 NN denotes regulation
T2414 2395-2402 JJ denotes genetic
T2415 2414-2416 IN denotes of
T2416 2417-2424 JJ denotes complex
T2417 2425-2435 NNS denotes phenotypes
T2418 2435-2437 , denotes ,
T2419 2437-2442 WDT denotes which
T2420 2457-2464 VB denotes improve
T2421 2443-2448 MD denotes would
T2422 2449-2456 RB denotes greatly
T2423 2465-2468 DT denotes the
T2424 2469-2480 NN denotes progression
T2425 2481-2485 IN denotes from
T2426 2486-2495 NN denotes candidate
T2427 2496-2501 NN denotes locus
T2428 2502-2504 IN denotes to
T2429 2505-2514 NN denotes candidate
T2430 2515-2519 NN denotes gene
T2431 2519-2520 . denotes .
T2432 2520-2840 sentence denotes Here we report the application of this integrated approach to study the significance of sex on the genetic determinants of obesity and the associated regulation of liver gene expression in an F2 intercross derived from the inbred strains C57BL/6J (B6) and C3H/HeJ (C3H) on an apolipoprotein E null (ApoE−/−) background.
T2433 2521-2525 RB denotes Here
T2434 2529-2535 VBP denotes report
T2435 2526-2528 PRP denotes we
T2436 2536-2539 DT denotes the
T2437 2540-2551 NN denotes application
T2438 2552-2554 IN denotes of
T2439 2555-2559 DT denotes this
T2440 2571-2579 NN denotes approach
T2441 2560-2570 VBN denotes integrated
T2442 2580-2582 TO denotes to
T2443 2583-2588 VB denotes study
T2444 2589-2592 DT denotes the
T2445 2593-2605 NN denotes significance
T2446 2606-2608 IN denotes of
T2447 2609-2612 NN denotes sex
T2448 2613-2615 IN denotes on
T2449 2616-2619 DT denotes the
T2450 2628-2640 NNS denotes determinants
T2451 2620-2627 JJ denotes genetic
T2452 2641-2643 IN denotes of
T2453 2644-2651 NN denotes obesity
T2454 2652-2655 CC denotes and
T2455 2656-2659 DT denotes the
T2456 2671-2681 NN denotes regulation
T2457 2660-2670 VBN denotes associated
T2458 2682-2684 IN denotes of
T2459 2685-2690 NN denotes liver
T2460 2696-2706 NN denotes expression
T2461 2691-2695 NN denotes gene
T2462 2707-2709 IN denotes in
T2463 2710-2712 DT denotes an
T2464 2716-2726 NN denotes intercross
T2465 2713-2715 NN denotes F2
T2466 2727-2734 VBN denotes derived
T2467 2735-2739 IN denotes from
T2468 2740-2743 DT denotes the
T2469 2751-2758 NNS denotes strains
T2470 2744-2750 JJ denotes inbred
T2471 2759-2764 NN denotes C57BL
T2472 2765-2767 NN denotes 6J
T2473 2764-2765 HYPH denotes /
T2474 2768-2769 -LRB- denotes (
T2475 2769-2771 NN denotes B6
T2476 2771-2772 -RRB- denotes )
T2477 2773-2776 CC denotes and
T2478 2777-2780 NN denotes C3H
T2479 2781-2784 NN denotes HeJ
T2480 2780-2781 HYPH denotes /
T2481 2785-2786 -LRB- denotes (
T2482 2786-2789 NN denotes C3H
T2483 2789-2790 -RRB- denotes )
T2484 2791-2793 IN denotes on
T2485 2794-2796 DT denotes an
T2486 2829-2839 NN denotes background
T2487 2797-2811 NN denotes apolipoprotein
T2488 2812-2813 NN denotes E
T2489 2814-2818 JJ denotes null
T2490 2819-2820 -LRB- denotes (
T2491 2820-2824 NN denotes ApoE
T2492 2824-2825 SYM denotes −
T2493 2825-2826 HYPH denotes /
T2494 2826-2827 SYM denotes −
T2495 2827-2828 -RRB- denotes )
T2496 2839-2840 . denotes .
T2497 2840-2972 sentence denotes The BXH.ApoE−/− population was designed to recapitulate several of the phenotypes associated with the so-called metabolic syndrome.
T2498 2841-2844 DT denotes The
T2499 2857-2867 NN denotes population
T2500 2845-2853 NN denotes BXH.ApoE
T2501 2853-2854 SYM denotes −
T2502 2854-2855 HYPH denotes /
T2503 2855-2856 SYM denotes −
T2504 2872-2880 VBN denotes designed
T2505 2868-2871 VBD denotes was
T2506 2881-2883 TO denotes to
T2507 2884-2896 VB denotes recapitulate
T2508 2897-2904 JJ denotes several
T2509 2905-2907 IN denotes of
T2510 2908-2911 DT denotes the
T2511 2912-2922 NNS denotes phenotypes
T2512 2923-2933 VBN denotes associated
T2513 2934-2938 IN denotes with
T2514 2939-2942 DT denotes the
T2515 2963-2971 NN denotes syndrome
T2516 2943-2945 RB denotes so
T2517 2946-2952 VBN denotes called
T2518 2945-2946 HYPH denotes -
T2519 2953-2962 JJ denotes metabolic
T2520 2971-2972 . denotes .
T2521 2972-3089 sentence denotes The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of QTLs on sex.
T2522 2973-2976 DT denotes The
T2523 2977-2982 NN denotes cross
T2524 2983-2991 VBZ denotes consists
T2525 2992-2994 IN denotes of
T2526 2995-2998 CD denotes 334
T2527 2999-3006 NNS denotes animals
T2528 3007-3009 IN denotes of
T2529 3010-3014 DT denotes both
T2530 3015-3020 NNS denotes sexes
T2531 3020-3022 , denotes ,
T2532 3022-3030 VBG denotes allowing
T2533 3031-3033 PRP denotes us
T2534 3050-3054 VB denotes test
T2535 3034-3036 TO denotes to
T2536 3037-3049 RB denotes specifically
T2537 3055-3058 IN denotes for
T2538 3059-3062 DT denotes the
T2539 3063-3073 NN denotes dependence
T2540 3074-3076 IN denotes of
T2541 3077-3081 NNS denotes QTLs
T2542 3082-3084 IN denotes on
T2543 3085-3088 NN denotes sex
T2544 3088-3089 . denotes .
T2545 3089-3199 sentence denotes We detected several thousand gene expression QTLs (eQTLs), a significant proportion of which were sex-biased.
T2546 3090-3092 PRP denotes We
T2547 3093-3101 VBD denotes detected
T2548 3102-3109 JJ denotes several
T2549 3110-3118 CD denotes thousand
T2550 3135-3139 NNS denotes QTLs
T2551 3119-3123 NN denotes gene
T2552 3124-3134 NN denotes expression
T2553 3140-3141 -LRB- denotes (
T2554 3141-3146 NNS denotes eQTLs
T2555 3146-3147 -RRB- denotes )
T2556 3147-3149 , denotes ,
T2557 3149-3150 DT denotes a
T2558 3163-3173 NN denotes proportion
T2559 3151-3162 JJ denotes significant
T2560 3183-3187 VBD denotes were
T2561 3174-3176 IN denotes of
T2562 3177-3182 WDT denotes which
T2563 3188-3191 NN denotes sex
T2564 3192-3198 VBN denotes biased
T2565 3191-3192 HYPH denotes -
T2566 3198-3199 . denotes .
T2567 3199-3335 sentence denotes We used these analyses to dissect the genetic regulation of the gonadal fat mass trait and to identify genes associated with the trait.
T2568 3200-3202 PRP denotes We
T2569 3203-3207 VBD denotes used
T2570 3208-3213 DT denotes these
T2571 3214-3222 NNS denotes analyses
T2572 3223-3225 TO denotes to
T2573 3226-3233 VB denotes dissect
T2574 3234-3237 DT denotes the
T2575 3246-3256 NN denotes regulation
T2576 3238-3245 JJ denotes genetic
T2577 3257-3259 IN denotes of
T2578 3260-3263 DT denotes the
T2579 3281-3286 NN denotes trait
T2580 3264-3271 JJ denotes gonadal
T2581 3276-3280 NN denotes mass
T2582 3272-3275 NN denotes fat
T2583 3287-3290 CC denotes and
T2584 3291-3293 TO denotes to
T2585 3294-3302 VB denotes identify
T2586 3303-3308 NNS denotes genes
T2587 3309-3319 VBN denotes associated
T2588 3320-3324 IN denotes with
T2589 3325-3328 DT denotes the
T2590 3329-3334 NN denotes trait
T2591 3334-3335 . denotes .
R250 T1994 T1995 nsubj Females,share
R251 T1996 T1994 cc and,Females
R252 T1997 T1994 conj males,Females
R253 T1998 T1999 advmod nearly,identical
R254 T1999 T2000 amod identical,information
R255 T2000 T1995 dobj information,share
R256 T2001 T2000 amod genetic,information
R257 T2002 T1995 punct ", ",share
R258 T2003 T1995 cc but,share
R259 T2004 T1995 conj vary,share
R260 T2005 T2004 advmod widely,vary
R261 T2006 T2004 prep with,vary
R262 T2007 T2006 pobj respect,with
R263 T2008 T2007 prep to,respect
R264 T2009 T2010 compound disease,susceptibility
R265 T2010 T2008 pobj susceptibility,to
R266 T2011 T2012 punct [,2
R267 T2012 T2004 parataxis 2,vary
R268 T2013 T2012 nummod 1,2
R269 T2014 T2012 punct ",",2
R270 T2015 T2012 punct ],2
R271 T2016 T1995 punct .,share
R272 T2018 T2019 advmod Apart,influences
R273 T2020 T2018 prep from,Apart
R274 T2021 T2022 det the,diseases
R275 T2022 T2020 pobj diseases,from
R276 T2023 T2022 amod obvious,diseases
R277 T2024 T2025 npadvmod gender,specific
R278 T2025 T2022 amod specific,diseases
R279 T2026 T2025 punct -,specific
R280 T2027 T2028 amod such,as
R281 T2028 T2022 prep as,diseases
R282 T2029 T2030 amod cervical,cancer
R283 T2030 T2028 pobj cancer,as
R284 T2031 T2029 cc or,cervical
R285 T2032 T2029 conj prostate,cervical
R286 T2033 T2019 punct ", ",influences
R287 T2034 T2019 nsubj sex,influences
R288 T2035 T2019 dobj susceptibility,influences
R289 T2036 T2035 prep to,susceptibility
R290 T2037 T2038 advmod nearly,all
R291 T2038 T2039 nummod all,diseases
R292 T2039 T2036 pobj diseases,to
R293 T2040 T2041 advmod highly,prevalent
R294 T2041 T2039 amod prevalent,diseases
R295 T2042 T2043 dep that,affect
R296 T2043 T2039 relcl affect,diseases
R297 T2044 T2045 det both,women
R298 T2045 T2043 dobj women,affect
R299 T2046 T2045 cc and,women
R300 T2047 T2045 conj men,women
R301 T2048 T2039 punct ", ",diseases
R302 T2049 T2039 prep including,diseases
R303 T2050 T2049 pobj atherosclerosis,including
R304 T2051 T2050 cc and,atherosclerosis
R305 T2052 T2050 conj diabetes,atherosclerosis
R306 T2053 T2050 cc and,atherosclerosis
R307 T2054 T2055 poss their,conditions
R308 T2055 T2050 conj conditions,atherosclerosis
R309 T2056 T2055 compound precursor,conditions
R310 T2057 T2055 prep of,conditions
R311 T2058 T2057 pobj hyperlipidemia,of
R312 T2059 T2058 punct ", ",hyperlipidemia
R313 T2060 T2058 conj obesity,hyperlipidemia
R314 T2061 T2060 punct ", ",obesity
R315 T2062 T2060 cc and,obesity
R316 T2063 T2064 compound insulin,resistance
R317 T2064 T2060 conj resistance,obesity
R318 T2065 T2019 punct .,influences
R319 T2067 T2068 nsubj These,are
R320 T2069 T2068 acomp multifactorial,are
R321 T2070 T2069 prep in,multifactorial
R322 T2071 T2072 poss their,pathogenesis
R323 T2072 T2070 pobj pathogenesis,in
R324 T2073 T2068 punct ", ",are
R325 T2074 T2068 advcl encompassing,are
R326 T2075 T2076 amod environmental,aspects
R327 T2076 T2074 dobj aspects,encompassing
R328 T2077 T2075 cc and,environmental
R329 T2078 T2075 conj behavioral,environmental
R330 T2079 T2076 punct ", ",aspects
R331 T2080 T2081 advmod as,as
R332 T2081 T2076 cc as,aspects
R333 T2082 T2081 advmod well,as
R334 T2083 T2084 amod significant,determination
R335 T2084 T2076 conj determination,aspects
R336 T2085 T2084 amod genetic,determination
R337 T2086 T2084 punct ", ",determination
R338 T2087 T2088 prep on,interact
R339 T2088 T2084 relcl interact,determination
R340 T2089 T2087 pobj which,on
R341 T2090 T2091 det these,factors
R342 T2091 T2088 nsubj factors,interact
R343 T2092 T2091 amod other,factors
R344 T2093 T2068 punct .,are
R345 T2095 T2096 det The,component
R346 T2096 T2098 nsubj component,is
R347 T2097 T2096 amod genetic,component
R348 T2099 T2098 acomp multigenic,is
R349 T2100 T2098 punct ", ",is
R350 T2101 T2098 prep with,is
R351 T2102 T2103 det the,heritability
R352 T2103 T2101 pobj heritability,with
R353 T2104 T2103 acl embedded,heritability
R354 T2105 T2104 prep in,embedded
R355 T2106 T2107 det the,variation
R356 T2107 T2105 pobj variation,in
R357 T2108 T2107 amod genetic,variation
R358 T2109 T2107 amod intrinsic,variation
R359 T2110 T2109 prep to,intrinsic
R360 T2111 T2112 poss our,population
R361 T2112 T2110 pobj population,to
R362 T2113 T2098 punct .,is
R363 T2115 T2116 mark Although,recognized
R364 T2116 T2124 advcl recognized,is
R365 T2117 T2118 det the,differences
R366 T2118 T2116 nsubjpass differences,recognized
R367 T2119 T2118 compound sex,differences
R368 T2120 T2118 prep in,differences
R369 T2121 T2122 compound disease,susceptibility
R370 T2122 T2120 pobj susceptibility,in
R371 T2123 T2116 auxpass are,recognized
R372 T2125 T2124 punct ", ",is
R373 T2126 T2127 det the,interplay
R374 T2127 T2124 nsubj interplay,is
R375 T2128 T2127 prep between,interplay
R376 T2129 T2128 pobj sex,between
R377 T2130 T2129 cc and,sex
R378 T2131 T2132 compound gene,expression
R379 T2132 T2129 conj expression,sex
R380 T2133 T2134 dep that,is
R381 T2134 T2127 relcl is,interplay
R382 T2135 T2134 prep at,is
R383 T2136 T2137 det the,basis
R384 T2137 T2135 pobj basis,at
R385 T2138 T2137 prep of,basis
R386 T2139 T2140 det these,differences
R387 T2140 T2138 pobj differences,of
R388 T2141 T2124 neg not,is
R389 T2142 T2143 advmod well,understood
R390 T2143 T2124 acomp understood,is
R391 T2144 T2124 punct .,is
R392 T2146 T2147 nsubj Females,inherit
R393 T2148 T2146 cc and,Females
R394 T2149 T2146 conj males,Females
R395 T2150 T2147 punct (,inherit
R396 T2151 T2147 prep on,inherit
R397 T2152 T2151 amod average,on
R398 T2153 T2147 punct ),inherit
R399 T2154 T2155 det the,genes
R400 T2155 T2147 dobj genes,inherit
R401 T2156 T2155 amod same,genes
R402 T2157 T2158 dep that,be
R403 T2158 T2155 relcl be,genes
R404 T2159 T2158 aux may,be
R405 T2160 T2161 compound risk,factors
R406 T2161 T2158 attr factors,be
R407 T2162 T2147 punct ", ",inherit
R408 T2163 T2147 cc but,inherit
R409 T2164 T2165 poss their,expression
R410 T2165 T2166 nsubj expression,varies
R411 T2166 T2147 conj varies,inherit
R412 T2167 T2165 cc and,expression
R413 T2168 T2165 conj effect,expression
R414 T2169 T2168 prep on,effect
R415 T2170 T2171 compound disease,risk
R416 T2171 T2169 pobj risk,on
R417 T2172 T2166 advmod significantly,varies
R418 T2173 T2166 punct .,varies
R419 T2175 T2176 det An,understanding
R420 T2176 T2177 nsubj understanding,is
R421 T2178 T2176 cc and,understanding
R422 T2179 T2176 conj recognition,understanding
R423 T2180 T2176 prep of,understanding
R424 T2181 T2182 det the,significance
R425 T2182 T2180 pobj significance,of
R426 T2183 T2182 prep of,significance
R427 T2184 T2185 amod specific,mutations
R428 T2185 T2183 pobj mutations,of
R429 T2186 T2187 npadvmod disease,associated
R430 T2187 T2185 amod associated,mutations
R431 T2188 T2187 punct -,associated
R432 T2189 T2185 compound polymorphisms,mutations
R433 T2190 T2185 punct /,mutations
R434 T2191 T2182 prep in,significance
R435 T2192 T2193 det the,context
R436 T2193 T2191 pobj context,in
R437 T2194 T2193 prep of,context
R438 T2195 T2194 pobj sex,of
R439 T2196 T2177 advmod therefore,is
R440 T2197 T2177 prep of,is
R441 T2198 T2199 amod critical,importance
R442 T2199 T2197 pobj importance,of
R443 T2200 T2199 amod clinical,importance
R444 T2201 T2177 punct .,is
R445 T2203 T2204 nsubj We,utilized
R446 T2205 T2204 aux have,utilized
R447 T2206 T2207 det the,mouse
R448 T2207 T2204 dobj mouse,utilized
R449 T2208 T2204 prep as,utilized
R450 T2209 T2210 det a,system
R451 T2210 T2208 pobj system,as
R452 T2211 T2210 compound model,system
R453 T2212 T2213 aux to,study
R454 T2213 T2204 advcl study,utilized
R455 T2214 T2215 det the,genetics
R456 T2215 T2213 dobj genetics,study
R457 T2216 T2215 prep of,genetics
R458 T2217 T2218 amod metabolic,diseases
R459 T2218 T2216 pobj diseases,of
R460 T2219 T2217 cc and,metabolic
R461 T2220 T2217 conj vascular,metabolic
R462 T2221 T2222 punct [,3
R463 T2222 T2204 parataxis 3,utilized
R464 T2223 T2224 punct –,5
R465 T2224 T2222 prep 5,3
R466 T2225 T2222 punct ],3
R467 T2226 T2204 punct .,utilized
R468 T2228 T2229 advmod Rather,utilize
R469 T2230 T2231 mark than,focus
R470 T2231 T2228 advcl focus,Rather
R471 T2232 T2231 advmod initially,focus
R472 T2233 T2231 prep on,focus
R473 T2234 T2235 amod natural,mutants
R474 T2235 T2233 pobj mutants,on
R475 T2236 T2234 cc or,natural
R476 T2237 T2234 conj induced,natural
R477 T2238 T2235 prep of,mutants
R478 T2239 T2240 amod single,genes
R479 T2240 T2238 pobj genes,of
R480 T2241 T2229 punct ", ",utilize
R481 T2242 T2229 nsubj we,utilize
R482 T2243 T2244 det the,variation
R483 T2244 T2229 dobj variation,utilize
R484 T2245 T2244 amod complex,variation
R485 T2246 T2244 amod endogenous,variation
R486 T2247 T2244 amod genetic,variation
R487 T2248 T2244 prep between,variation
R488 T2249 T2248 pobj strains,between
R489 T2250 T2249 prep in,strains
R490 T2251 T2252 amod genetic,crosses
R491 T2252 T2250 pobj crosses,in
R492 T2253 T2254 aux to,identify
R493 T2254 T2229 advcl identify,utilize
R494 T2255 T2256 amod causative,loci
R495 T2256 T2254 dobj loci,identify
R496 T2257 T2256 amod genetic,loci
R497 T2258 T2256 cc and,loci
R498 T2259 T2260 advmod ultimately,variations
R499 T2260 T2256 conj variations,loci
R500 T2261 T2260 det the,variations
R501 T2262 T2260 amod underlying,variations
R502 T2263 T2260 amod responsible,variations
R503 T2264 T2263 prep for,responsible
R504 T2265 T2266 compound trait,differences
R505 T2266 T2264 pobj differences,for
R506 T2267 T2268 punct [,6
R507 T2268 T2229 parataxis 6,utilize
R508 T2269 T2268 punct ],6
R509 T2270 T2229 punct .,utilize
R510 T2272 T2273 det This,design
R511 T2273 T2274 nsubj design,reflects
R512 T2275 T2276 advmod more,closely
R513 T2276 T2274 advmod closely,reflects
R514 T2277 T2278 det the,situation
R515 T2278 T2274 dobj situation,reflects
R516 T2279 T2278 acl faced,situation
R517 T2280 T2281 advmod when,studying
R518 T2281 T2279 advcl studying,faced
R519 T2282 T2283 amod human,populations
R520 T2283 T2281 dobj populations,studying
R521 T2284 T2274 punct .,reflects
R522 T2286 T2287 det The,composition
R523 T2287 T2289 nsubjpass composition,restricted
R524 T2288 T2287 amod genetic,composition
R525 T2290 T2287 prep of,composition
R526 T2291 T2292 det each,mouse
R527 T2292 T2290 pobj mouse,of
R528 T2293 T2292 amod individual,mouse
R529 T2294 T2289 auxpass is,restricted
R530 T2295 T2289 prep to,restricted
R531 T2296 T2295 pobj that,to
R532 T2297 T2296 prep of,that
R533 T2298 T2299 det the,strains
R534 T2299 T2297 pobj strains,of
R535 T2300 T2299 nummod two,strains
R536 T2301 T2299 amod parental,strains
R537 T2302 T2289 cc and,restricted
R538 T2303 T2304 auxpass is,defined
R539 T2304 T2289 conj defined,restricted
R540 T2305 T2304 prep at,defined
R541 T2306 T2307 det every,locus
R542 T2307 T2305 pobj locus,at
R543 T2308 T2307 prep across,locus
R544 T2309 T2310 det the,genome
R545 T2310 T2308 pobj genome,across
R546 T2311 T2289 punct .,restricted
R547 T2313 T2314 det The,application
R548 T2314 T2315 nsubj application,allows
R549 T2316 T2314 prep of,application
R550 T2317 T2318 amod quantitative,trait
R551 T2318 T2319 nmod trait,locus
R552 T2319 T2320 nmod locus,analysis
R553 T2320 T2316 pobj analysis,of
R554 T2321 T2319 punct (,locus
R555 T2322 T2319 appos QTL,locus
R556 T2323 T2320 punct ),analysis
R557 T2324 T2325 det the,identification
R558 T2325 T2315 dobj identification,allows
R559 T2326 T2325 prep of,identification
R560 T2327 T2328 det those,regions
R561 T2328 T2326 pobj regions,of
R562 T2329 T2328 amod chromosomal,regions
R563 T2330 T2331 dep that,contain
R564 T2331 T2328 relcl contain,regions
R565 T2332 T2333 det a,variation
R566 T2333 T2331 dobj variation,contain
R567 T2334 T2333 amod genetic,variation
R568 T2335 T2336 dep that,influences
R569 T2336 T2333 relcl influences,variation
R570 T2337 T2338 compound trait,expression
R571 T2338 T2336 dobj expression,influences
R572 T2339 T2340 punct (,see
R573 T2340 T2315 parataxis see,allows
R574 T2341 T2340 prep for,see
R575 T2342 T2343 det a,review
R576 T2343 T2341 pobj review,for
R577 T2344 T2343 amod comprehensive,review
R578 T2345 T2343 prep on,review
R579 T2346 T2345 pobj QTLs,on
R580 T2347 T2340 punct [,see
R581 T2348 T2340 dobj 7,see
R582 T2349 T2340 punct ],see
R583 T2350 T2340 punct ),see
R584 T2351 T2315 punct .,allows
R585 T2353 T2354 nsubj We,extended
R586 T2355 T2356 punct [,8
R587 T2356 T2353 parataxis 8,We
R588 T2357 T2356 nummod 5,8
R589 T2358 T2356 punct ",",8
R590 T2359 T2356 punct ],8
R591 T2360 T2353 punct ", ",We
R592 T2361 T2353 cc and,We
R593 T2362 T2353 conj others,We
R594 T2363 T2364 punct [,9
R595 T2364 T2362 parataxis 9,others
R596 T2365 T2366 punct –,17
R597 T2366 T2364 prep 17,9
R598 T2367 T2364 punct ],9
R599 T2368 T2354 punct ", ",extended
R600 T2369 T2354 aux have,extended
R601 T2370 T2354 advmod recently,extended
R602 T2371 T2372 det the,power
R603 T2372 T2354 dobj power,extended
R604 T2373 T2372 prep of,power
R605 T2374 T2375 det this,approach
R606 T2375 T2373 pobj approach,of
R607 T2376 T2354 prep by,extended
R608 T2377 T2376 pcomp incorporating,by
R609 T2378 T2379 npadvmod genome,wide
R610 T2379 T2381 amod wide,analysis
R611 T2380 T2379 punct -,wide
R612 T2381 T2377 dobj analysis,incorporating
R613 T2382 T2383 compound gene,expression
R614 T2383 T2381 compound expression,analysis
R615 T2384 T2381 compound array,analysis
R616 T2385 T2381 punct ", ",analysis
R617 T2386 T2387 dep which,allows
R618 T2387 T2381 relcl allows,analysis
R619 T2388 T2389 nsubj us,model
R620 T2389 T2387 ccomp model,allows
R621 T2390 T2389 aux to,model
R622 T2391 T2392 det the,genetics
R623 T2392 T2389 dobj genetics,model
R624 T2393 T2392 punct “,genetics
R625 T2394 T2392 prep of,genetics
R626 T2395 T2396 compound gene,expression
R627 T2396 T2394 pobj expression,of
R628 T2397 T2389 punct ”,model
R629 T2398 T2389 advcl using,model
R630 T2399 T2400 amod similar,methods
R631 T2400 T2398 dobj methods,using
R632 T2401 T2354 punct .,extended
R633 T2403 T2404 det An,extension
R634 T2404 T2406 nsubj extension,is
R635 T2405 T2404 amod immediate,extension
R636 T2407 T2404 prep of,extension
R637 T2408 T2409 det this,approach
R638 T2409 T2407 pobj approach,of
R639 T2410 T2406 prep toward,is
R640 T2411 T2410 pcomp dissecting,toward
R641 T2412 T2413 det the,regulation
R642 T2443 T2437 acl study,application
R643 T2413 T2411 dobj regulation,dissecting
R644 T2444 T2445 det the,significance
R645 T2414 T2413 amod genetic,regulation
R646 T2445 T2443 dobj significance,study
R647 T2446 T2445 prep of,significance
R648 T2415 T2413 prep of,regulation
R649 T2447 T2446 pobj sex,of
R650 T2448 T2445 prep on,significance
R651 T2416 T2417 amod complex,phenotypes
R652 T2449 T2450 det the,determinants
R653 T2450 T2448 pobj determinants,on
R654 T2451 T2450 amod genetic,determinants
R655 T2417 T2415 pobj phenotypes,of
R656 T2452 T2450 prep of,determinants
R657 T2453 T2452 pobj obesity,of
R658 T2454 T2450 cc and,determinants
R659 T2418 T2413 punct ", ",regulation
R660 T2455 T2456 det the,regulation
R661 T2456 T2450 conj regulation,determinants
R662 T2457 T2456 amod associated,regulation
R663 T2419 T2420 dep which,improve
R664 T2458 T2456 prep of,regulation
R665 T2459 T2460 compound liver,expression
R666 T2460 T2458 pobj expression,of
R667 T2461 T2460 compound gene,expression
R668 T2462 T2443 prep in,study
R669 T2420 T2413 relcl improve,regulation
R670 T2463 T2464 det an,intercross
R671 T2464 T2462 pobj intercross,in
R672 T2465 T2464 compound F2,intercross
R673 T2421 T2420 aux would,improve
R674 T2466 T2464 acl derived,intercross
R675 T2467 T2466 prep from,derived
R676 T2468 T2469 det the,strains
R677 T2422 T2420 advmod greatly,improve
R678 T2469 T2467 pobj strains,from
R679 T2470 T2469 amod inbred,strains
R680 T2471 T2472 compound C57BL,6J
R681 T2472 T2469 appos 6J,strains
R682 T2423 T2424 det the,progression
R683 T2424 T2420 dobj progression,improve
R684 T2473 T2472 punct /,6J
R685 T2474 T2475 punct (,B6
R686 T2425 T2424 prep from,progression
R687 T2475 T2472 parataxis B6,6J
R688 T2476 T2475 punct ),B6
R689 T2477 T2472 cc and,6J
R690 T2426 T2427 compound candidate,locus
R691 T2478 T2479 compound C3H,HeJ
R692 T2479 T2472 conj HeJ,6J
R693 T2480 T2479 punct /,HeJ
R694 T2427 T2425 pobj locus,from
R695 T2481 T2482 punct (,C3H
R696 T2482 T2479 parataxis C3H,HeJ
R697 T2483 T2482 punct ),C3H
R698 T2428 T2424 prep to,progression
R699 T2484 T2469 prep on,strains
R700 T2485 T2486 det an,background
R701 T2429 T2430 compound candidate,gene
R702 T2486 T2484 pobj background,on
R703 T2487 T2488 compound apolipoprotein,E
R704 T2488 T2489 npadvmod E,null
R705 T2430 T2428 pobj gene,to
R706 T2489 T2486 amod null,background
R707 T2490 T2491 punct (,ApoE
R708 T2491 T2486 parataxis ApoE,background
R709 T2431 T2406 punct .,is
R710 T2492 T2491 punct −,ApoE
R711 T2493 T2491 punct /,ApoE
R712 T2494 T2491 punct −,ApoE
R713 T2433 T2434 advmod Here,report
R714 T2495 T2491 punct ),ApoE
R715 T2496 T2434 punct .,report
R716 T2498 T2499 det The,population
R717 T2435 T2434 nsubj we,report
R718 T2499 T2504 nsubjpass population,designed
R719 T2500 T2499 nmod BXH.ApoE,population
R720 T2501 T2500 punct −,BXH.ApoE
R721 T2502 T2500 punct /,BXH.ApoE
R722 T2503 T2500 punct −,BXH.ApoE
R723 T2505 T2504 auxpass was,designed
R724 T2506 T2507 aux to,recapitulate
R725 T2436 T2437 det the,application
R726 T2507 T2504 advcl recapitulate,designed
R727 T2508 T2507 dobj several,recapitulate
R728 T2509 T2508 prep of,several
R729 T2437 T2434 dobj application,report
R730 T2510 T2511 det the,phenotypes
R731 T2511 T2509 pobj phenotypes,of
R732 T2512 T2511 acl associated,phenotypes
R733 T2438 T2437 prep of,application
R734 T2513 T2512 prep with,associated
R735 T2439 T2440 det this,approach
R736 T2514 T2515 det the,syndrome
R737 T2515 T2513 pobj syndrome,with
R738 T2516 T2517 advmod so,called
R739 T2517 T2515 amod called,syndrome
R740 T2440 T2438 pobj approach,of
R741 T2518 T2517 punct -,called
R742 T2519 T2515 amod metabolic,syndrome
R743 T2520 T2504 punct .,designed
R744 T2441 T2440 amod integrated,approach
R745 T2522 T2523 det The,cross
R746 T2523 T2524 nsubj cross,consists
R747 T2442 T2443 aux to,study
R748 T2525 T2524 prep of,consists
R749 T2549 T2550 nummod thousand,QTLs
R750 T2526 T2527 nummod 334,animals
R751 T2527 T2525 pobj animals,of
R752 T2528 T2527 prep of,animals
R753 T2529 T2530 det both,sexes
R754 T2530 T2528 pobj sexes,of
R755 T2531 T2524 punct ", ",consists
R756 T2550 T2547 dobj QTLs,detected
R757 T2532 T2524 advcl allowing,consists
R758 T2533 T2534 nsubj us,test
R759 T2534 T2532 ccomp test,allowing
R760 T2551 T2550 compound gene,QTLs
R761 T2535 T2534 aux to,test
R762 T2536 T2534 advmod specifically,test
R763 T2537 T2534 prep for,test
R764 T2552 T2550 compound expression,QTLs
R765 T2538 T2539 det the,dependence
R766 T2539 T2537 pobj dependence,for
R767 T2540 T2539 prep of,dependence
R768 T2553 T2550 punct (,QTLs
R769 T2541 T2540 pobj QTLs,of
R770 T2542 T2539 prep on,dependence
R771 T2543 T2542 pobj sex,on
R772 T2544 T2524 punct .,consists
R773 T2546 T2547 nsubj We,detected
R774 T2554 T2550 appos eQTLs,QTLs
R775 T2548 T2549 amod several,thousand
R776 T2555 T2550 punct ),QTLs
R777 T2556 T2550 punct ", ",QTLs
R778 T2557 T2558 det a,proportion
R779 T2558 T2560 dep proportion,were
R780 T2559 T2558 amod significant,proportion
R781 T2560 T2550 relcl were,QTLs
R782 T2561 T2558 prep of,proportion
R783 T2562 T2561 pobj which,of
R784 T2563 T2564 npadvmod sex,biased
R785 T2564 T2560 acomp biased,were
R786 T2565 T2564 punct -,biased
R787 T2566 T2547 punct .,detected
R788 T2568 T2569 nsubj We,used
R789 T2570 T2571 det these,analyses
R790 T2571 T2569 dobj analyses,used
R791 T2572 T2573 aux to,dissect
R792 T2573 T2569 advcl dissect,used
R793 T2574 T2575 det the,regulation
R794 T2575 T2573 dobj regulation,dissect
R795 T2576 T2575 amod genetic,regulation
R796 T2577 T2575 prep of,regulation
R797 T2578 T2579 det the,trait
R798 T2579 T2577 pobj trait,of
R799 T2580 T2581 amod gonadal,mass
R800 T2581 T2579 compound mass,trait
R801 T2582 T2581 compound fat,mass
R802 T2583 T2573 cc and,dissect
R803 T2584 T2585 aux to,identify
R804 T2585 T2573 conj identify,dissect
R805 T2586 T2585 dobj genes,identify
R806 T2587 T2586 acl associated,genes
R807 T2588 T2587 prep with,associated
R808 T2589 T2590 det the,trait
R809 T2590 T2588 pobj trait,with
R810 T2591 T2569 punct .,used